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TBC1D15 Gene

protein-coding   GIFtS: 52
GCID: GC12P072233

TBC1 Domain Family, Member 15

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 151 2     TBC1 Domain Family Member 152
GAP For RAB72 3     Tre-2-Budding Uninhibited By Benzimidazole-Cell Division Cycle 16 Domain,
Domain Family Member 152
GTPase-Activating Protein RAB72 3     Tre2/Bub2/Cdc16 Domain Family Member 152
RAB7-GAP2     Rab7-GAP3

External Ids:    HGNC: 256941   Entrez Gene: 647862   Ensembl: ENSG000001217497   OMIM: 6126625   UniProtKB: Q8TC073   

Export aliases for TBC1D15 gene to outside databases

Previous GC identifers: GC12P070519 GC12P069283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBC1D15 Gene:
This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a
conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may
function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Apr 2009)

GeneCards Summary for TBC1D15 Gene:
TBC1D15 (TBC1 domain family, member 15) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is SGSM1.

UniProtKB/Swiss-Prot: TBC15_HUMAN, Q8TC07
Function: Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)

Gene Wiki entry for TBC1D15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D15 gene promoter:
         Nkx3-1   Egr-1   Nkx3-1 v1   Nkx2-5   LCR-F1   GATA-1   RORalpha1   IRF-7A   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D15 promoter sequence
   Search Chromatin IP Primers for TBC1D15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.1   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q15

TBC1D15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D15 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P072233:  view genomic region     (about GC identifiers)

Start:
72,233,487 bp from pter      End:
72,320,629 bp from pter
Size:
87,143 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBC15_HUMAN, Q8TC07 (See protein sequence)
Recommended Name: TBC1 domain family member 15  
Size: 691 amino acids; 79491 Da
Secondary accessions: B4DMT9 B9A6L6 J3KNI9 Q9HA83
Alternative splicing: 3 isoforms:  Q8TC07-1   Q8TC07-2   Q8TC07-3   (No experimental confirmation available. Contains a phosphoserine at position 213)

Explore the universe of human proteins at neXtProt for TBC1D15: NX_Q8TC07

Explore proteomics data for TBC1D15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys26, Lys68, Lys81, Lys107, Lys125, Lys239, Lys240, Lys288, Lys324,
                                 Lys339, Lys369, Lys379, Lys580, Lys589
  • Modification sites at PhosphoSitePlus

  • See TBC1D15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139685.2  NP_001139686.1  NP_073608.4  

    ENSEMBL proteins: 
     ENSP00000449643   ENSP00000448182   ENSP00000417308   ENSP00000419365   ENSP00000418091  
     ENSP00000318262   ENSP00000418467   ENSP00000420678   ENSP00000420190   ENSP00000376986  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000195 Rab-GTPase-TBC_dom
     IPR021935 DUF3548

    Graphical View of Domain Structure for InterPro Entry Q8TC07

    ProtoNet protein and cluster: Q8TC07

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TBC15_HUMAN, Q8TC07
    Similarity: Contains 1 Rab-GAP TBC domain


    Find genes that share domains with TBC1D15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBC15_HUMAN, Q8TC07
    Function: Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity ISS--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TBC1D15           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TBC1D15

    miRNA
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    miRTarBase miRNAs that target TBC1D15:
    hsa-mir-20a-5p (MIRT050522), hsa-mir-484 (MIRT041974), hsa-let-7b-5p (MIRT032446), hsa-mir-17-5p (MIRT050825)

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    Selected qRT-PCR Assays for microRNAs that regulate TBC1D15 (see all 100):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-519a hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D15 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBC15_HUMAN, Q8TC07: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endosome2
    extracellular2
    mitochondrion2
    nucleus2
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with TBC1D15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D15
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TBC1D15 (Q8TC071, 3 ENSP000003182624) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1Q9H0R81, 3EBI-1048247,EBI-746969 I2D: score=1 
    GABARAPL2P605201, 3EBI-1048247,EBI-720116 I2D: score=1 
    MAP1LC3BQ9GZQ81, 3EBI-1048247,EBI-373144 I2D: score=1 
    GABARAPO951661, 3, ENSP000003068664EBI-1048247,EBI-712001 I2D: score=3 STRING: ENSP00000306866
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ISS--
    GO:0032851positive regulation of Rab GTPase activity ----

    Find genes that share ontologies with TBC1D15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D15 (TBC15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBC1D15 gene (3 alternative transcripts): 
    NM_001146213.1  NM_001146214.1  NM_022771.4  

    Unigene Cluster for TBC1D15:

    TBC1 domain family, member 15
    Hs.284630  [show with all ESTs]
    Unigene Representative Sequence: NM_001146214
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482439 ENST00000550746(uc009zrv.2 uc001swu.3 uc010stt.2 uc001swv.3 uc001sww.3)
    ENST00000498482 ENST00000474468 ENST00000549402 ENST00000472611 ENST00000491063
    ENST00000319106 ENST00000462788 ENST00000485960 ENST00000468049 ENST00000546932
    ENST00000460818 ENST00000483828 ENST00000548679 ENST00000479971 ENST00000546450
    ENST00000393309
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    Selected qRT-PCR Assays for microRNAs that regulate TBC1D15 (see all 100):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-519a hsa-miR-890
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    Additional mRNA sequence: 

    AB449901.1 AK022147.1 AK225221.1 AK225747.1 AK292306.1 AK297626.1 AK307922.1 AL157464.1 
    AL833639.1 BC028352.2 NR_027449.1 

    17 DOTS entries:

    DT.443226  DT.97820282  DT.95273082  DT.121128159  DT.75101515  DT.100024976  DT.97824051  DT.40273168 
    DT.121128136  DT.40202512  DT.95273081  DT.121128078  DT.121128148  DT.75169358  DT.97859204  DT.99953406 
    DT.120734273 

    Selected AceView cDNA sequences (see all 198):

    AA524016 BU540713 BM765672 BU608928 AI537282 AI289810 AL157464 BC028352 
    AI857368 AU138693 BQ026160 NM_022771 BQ775034 AW105686 BQ420873 BM765659 
    CA414859 AA233305 AA399500 BM756345 AI371869 AI291692 AA635017 AL833639 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                              -                       -                                             
    SP2:                                            -                 -                       -                                             
    SP3:                                -           -                 -                       -                                             
    SP4:                                                                                      -                                             
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TBC1D15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTAAGGTT
    TBC1D15 Expression
    About this image


    TBC1D15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TBC1D15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284630
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TBC1D15 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d151 , 5 TBC1 domain family, member 151, 5 87.58(n)1
    91.65(a)1
      10 (63.51 cM)5
    666871  NM_025706.31  NP_079982.31 
     1151978775 
    chicken
    (Gallus gallus)
    Aves TBC1D151 TBC1 domain family, member 15 78.93(n)
    81.38(a)
      417857  NM_001012809.2  NP_001012827.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D156
    TBC1 domain family, member 15
    80(a)
    1 ↔ 1
    5(38518972-38548454)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC063206.12   -- 76.92(n)    BC063206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570503602   -- 75.27(n)    57050360 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tbc1d15-171 Tbc1d15-17 46.1(n)
    37.78(a)
      33184  NM_134659.4  NP_608503.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-151 tbc-15 55.65(n)
    50.42(a)
      3565412  NM_182167.3  NP_871967.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP7(YDL234C)4 GTPase-activating protein for yeast Rab family members more   --   4(36477-34237) 851364  NP_010047.1 
    soybean
    (Glycine max)
    eudicotyledons 467897532   -- 70.43(n)  
    wheat
    (Triticum aestivum)
    Liliopsida Ta.125322 Triticum aestivum transcribed sequence with moderate more 73.89(n)    CD935796.1 


    ENSEMBL Gene Tree for TBC1D15 (if available)
    TreeFam Gene Tree for TBC1D15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D15 gene
    SGSM12  TBC1D172  TBC1D162  SGSM22  TBC1D252  
    4 SIMAP similar genes for TBC1D15 using alignment to 8 protein entries:     TBC15_HUMAN (see all proteins):
    DKFZp761D0223    TBC1D17    TBC1D16    TBC1D21

    Find genes that share paralogs with TBC1D15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D15 (see all 1657)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836787431,2
    --72231501(+) TAGGAA/GATTTT 4 -- us2k10--------
    rs1513385281,2
    --72231528(+) GATAAC/TGGCCC 4 -- us2k10--------
    rs757832801,2
    C,F--72231529(+) ATAACG/AGCCCA 4 -- us2k11Minor allele frequency- A:0.02WA 118
    rs781626321,2
    C,F--72231689(+) CTGTAG/TTTCTC 4 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1878795231,2
    --72231814(+) CACATC/TAAAAT 4 -- us2k10--------
    rs1150764601,2
    F--72231873(+) TGGGTC/TATCAG 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs3287601,2
    C,F,H--72232107(-) GAGATT/CGCGTG 4 -- us2k17Minor allele frequency- C:0.08NS EA WA 542
    rs1161781001,2
    C,F--72232159(+) CTTTCC/GTCACC 4 -- us2k11Minor allele frequency- G:0.03WA 118
    rs118316221,2
    C,F,H--72232186(+) GTCACA/CTAACC 4 -- us2k121Minor allele frequency- C:0.06NS EA NA WA 2616
    rs3287611,2
    C,F,H--72232292(-) GTCCAT/CTGAGG 4 -- us2k124Minor allele frequency- C:0.09NS EA NA WA 2770

    HapMap Linkage Disequilibrium report for TBC1D15 (72233487 - 72320629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TBC1D15 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662131CNV Deletion23128226
    esv2657617CNV Deletion23128226
    nsv8988CNV Loss18304495
    nsv518498CNV Loss19592680
    nsv899254CNV Loss21882294
    nsv899255CNV Gain21882294
    nsv818924CNV Gain17921354
    esv35030CNV Gain17911159
    dgv1447n71CNV Gain21882294
    essv4115CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D15
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612662    OMIM disorders: --


    Find genes that share disorders with TBC1D15           About GenesLikeMe

    Genetic Association Database (GAD): TBC1D15

    Export disorders for TBC1D15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D15 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with TBC1D15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7. (PubMed id 16055087)1, 3 Zhang X.M....Rowe T. (Biochem. Biophys. Res. Commun. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. (PubMed id 23077178)1 Onoue K....Ishihara N. (J. Cell. Sci. 2013)
    7. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. (PubMed id 23503661)1 Sarraf S.A....Harper J.W. (Nature 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64786 HGNC: 25694 AceView: TBC1D15 Ensembl:ENSG00000121749 euGenes: HUgn64786
    ECgene: TBC1D15 H-InvDB: TBC1D15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBC1D15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D15 gene:
    Search GeneIP for patents involving TBC1D15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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