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Aliases for TBC1D15 Gene

Aliases for TBC1D15 Gene

  • TBC1 Domain Family Member 15 2 3 5
  • GTPase-Activating Protein RAB7 3 4
  • TBC1 Domain Family, Member 15 2 3
  • GAP For RAB7 3 4
  • RAB7-GAP 3 4
  • Tre-2-Budding Uninhibited By Benzimidazole-Cell Division Cycle 16 Domain, Domain Family Member 15 3
  • Tre2/Bub2/Cdc16 Domain Family Member 15 3

External Ids for TBC1D15 Gene

Previous GeneCards Identifiers for TBC1D15 Gene

  • GC12P070519
  • GC12P072233
  • GC12P069283

Summaries for TBC1D15 Gene

Entrez Gene Summary for TBC1D15 Gene

  • This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for TBC1D15 Gene

TBC1D15 (TBC1 Domain Family Member 15) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SGSM2.

UniProtKB/Swiss-Prot for TBC1D15 Gene

  • Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).

Gene Wiki entry for TBC1D15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D15 Gene

Genomics for TBC1D15 Gene

Regulatory Elements for TBC1D15 Gene

Enhancers for TBC1D15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBC1D15 on UCSC Golden Path with GeneCards custom track

Promoters for TBC1D15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBC1D15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D15 Gene

71,839,707 bp from pter
71,927,248 bp from pter
87,542 bases
Plus strand

Genomic View for TBC1D15 Gene

Genes around TBC1D15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D15 Gene

Proteins for TBC1D15 Gene

  • Protein details for TBC1D15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 15
    Protein Accession:
    Secondary Accessions:
    • B4DMT9
    • B9A6L6
    • J3KNI9
    • Q9HA83

    Protein attributes for TBC1D15 Gene

    691 amino acids
    Molecular mass:
    79491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D15 Gene


neXtProt entry for TBC1D15 Gene

Proteomics data for TBC1D15 Gene at MOPED

Post-translational modifications for TBC1D15 Gene

  • Ubiquitination at Lys 10, Lys 26, Lys 68, Lys 81, Lys 107, Lys 125, Lys 239, Lys 240, Lys 288, Lys 324, Lys 339, Lys 369, Lys 379, Lys 580, Lys 589, Lys 200, and Lys 220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D15 Gene

Domains & Families for TBC1D15 Gene

Protein Domains for TBC1D15 Gene


Suggested Antigen Peptide Sequences for TBC1D15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D15: view

No data available for Gene Families for TBC1D15 Gene

Function for TBC1D15 Gene

Molecular function for TBC1D15 Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).

Gene Ontology (GO) - Molecular Function for TBC1D15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
genes like me logo Genes that share ontologies with TBC1D15: view
genes like me logo Genes that share phenotypes with TBC1D15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D15 Gene

Localization for TBC1D15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D15 Gene


Subcellular locations from

Jensen Localization Image for TBC1D15 Gene COMPARTMENTS Subcellular localization image for TBC1D15 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 3
nucleus 2
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TBC1D15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TBC1D15: view

Pathways & Interactions for TBC1D15 Gene

SuperPathways for TBC1D15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D15: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D15 Gene

Drugs & Compounds for TBC1D15 Gene

No Compound Related Data Available

Transcripts for TBC1D15 Gene

Unigene Clusters for TBC1D15 Gene

TBC1 domain family, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -

Relevant External Links for TBC1D15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D15 Gene

mRNA expression in normal human tissues for TBC1D15 Gene

Protein differential expression in normal tissues from HIPED for TBC1D15 Gene

This gene is overexpressed in Bone (24.4), Lymph node (10.3), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D15 Gene

SOURCE GeneReport for Unigene cluster for TBC1D15 Gene Hs.284630

genes like me logo Genes that share expression patterns with TBC1D15: view

Protein tissue co-expression partners for TBC1D15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D15 Gene

Orthologs for TBC1D15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBC1D15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBC1D15 35
  • 93.29 (n)
  • 94.79 (a)
TBC1D15 36
  • 93 (a)
(Canis familiaris)
Mammalia TBC1D15 35
  • 93.97 (n)
  • 95.37 (a)
TBC1D15 36
  • 93 (a)
(Mus musculus)
Mammalia Tbc1d15 35
  • 87.58 (n)
  • 91.65 (a)
Tbc1d15 16
Tbc1d15 36
  • 92 (a)
(Pan troglodytes)
Mammalia TBC1D15 35
  • 99.66 (n)
  • 99.71 (a)
TBC1D15 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tbc1d15 35
  • 88.43 (n)
  • 93 (a)
(Monodelphis domestica)
Mammalia TBC1D15 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D15 36
  • 84 (a)
(Gallus gallus)
Aves TBC1D15 35
  • 78.93 (n)
  • 81.38 (a)
TBC1D15 36
  • 82 (a)
(Anolis carolinensis)
Reptilia TBC1D15 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d15 35
  • 74.92 (n)
  • 74.77 (a)
(Danio rerio)
Actinopterygii tbc1d15 35
  • 65.32 (n)
  • 65.53 (a)
tbc1d15 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007911 35
  • 47.59 (n)
  • 36.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tbc1d15-17 35
  • 46.1 (n)
  • 37.78 (a)
CG11490 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea tbc-15 35
  • 55.65 (n)
  • 50.42 (a)
tbc-15 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 25 (a)
GYP7 38
(Triticum aestivum)
Liliopsida Ta.12532 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4773 36
  • 42 (a)
Species with no ortholog for TBC1D15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TBC1D15 Gene

Gene Tree for TBC1D15 (if available)
Gene Tree for TBC1D15 (if available)

Paralogs for TBC1D15 Gene

Paralogs for TBC1D15 Gene

genes like me logo Genes that share paralogs with TBC1D15: view

Variants for TBC1D15 Gene

Sequence variations from dbSNP and Humsavar for TBC1D15 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2016880 -- 71,864,805(-) taggt(A/G)ggccg intron-variant
rs2052732 -- 71,881,429(-) ctaac(C/T)taccc intron-variant
rs186627 -- 71,841,266(-) GCTTC(A/G)TTGCC intron-variant
rs7136234 -- 71,870,603(+) TTATA(A/T)TGTAG intron-variant
rs7137012 -- 71,914,866(+) CCTTT(G/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D15 Gene

Variant ID Type Subtype PubMed ID
dgv519e1 CNV Complex 17122850
dgv1447n71 CNV Gain 21882294
esv35030 CNV Gain 17911159
essv4115 CNV CNV 17122850
nsv818924 CNV Gain 17921354
nsv899254 CNV Loss 21882294
nsv899255 CNV Gain 21882294
nsv8988 CNV Loss 18304495
esv2657617 CNV Deletion 23128226
esv2662131 CNV Deletion 23128226
nsv518498 CNV Loss 19592680

Variation tolerance for TBC1D15 Gene

Residual Variation Intolerance Score: 5.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TBC1D15 Gene

Disorders for TBC1D15 Gene

Relevant External Links for TBC1D15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TBC1D15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D15 Gene

Publications for TBC1D15 Gene

  1. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4 67
  2. TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7. (PMID: 16055087) Zhang X.M. … Rowe T. (Biochem. Biophys. Res. Commun. 2005) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TBC1D15 Gene

Sources for TBC1D15 Gene