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Aliases for TBC1D15 Gene

Aliases for TBC1D15 Gene

  • TBC1 Domain Family, Member 15 2 3
  • GTPase-Activating Protein RAB7 3 4
  • GAP For RAB7 3 4
  • RAB7-GAP 3 4
  • Tre-2-Budding Uninhibited By Benzimidazole-Cell Division Cycle 16 Domain, Domain Family Member 15 3
  • Tre2/Bub2/Cdc16 Domain Family Member 15 3
  • TBC1 Domain Family Member 15 3

External Ids for TBC1D15 Gene

Previous GeneCards Identifiers for TBC1D15 Gene

  • GC12P070519
  • GC12P072233
  • GC12P069283

Summaries for TBC1D15 Gene

Entrez Gene Summary for TBC1D15 Gene

  • This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for TBC1D15 Gene

TBC1D15 (TBC1 Domain Family, Member 15) is a Protein Coding gene. An important paralog of this gene is SGSM2.

UniProtKB/Swiss-Prot for TBC1D15 Gene

  • Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).

Gene Wiki entry for TBC1D15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D15 Gene

Genomics for TBC1D15 Gene

Regulatory Elements for TBC1D15 Gene

Genomic Location for TBC1D15 Gene

71,839,707 bp from pter
71,927,248 bp from pter
87,542 bases
Plus strand

Genomic View for TBC1D15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D15 Gene

Proteins for TBC1D15 Gene

  • Protein details for TBC1D15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 15
    Protein Accession:
    Secondary Accessions:
    • B4DMT9
    • B9A6L6
    • J3KNI9
    • Q9HA83

    Protein attributes for TBC1D15 Gene

    691 amino acids
    Molecular mass:
    79491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D15 Gene


neXtProt entry for TBC1D15 Gene

Proteomics data for TBC1D15 Gene at MOPED

Post-translational modifications for TBC1D15 Gene

  • Ubiquitination at Lys10, Lys26, Lys68, Lys81, Lys107, Lys125, Lys239, Lys240, Lys288, Lys324, Lys339, Lys369, Lys379, Lys580, Lys589, Lys200, and Lys220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D15 Gene

Domains for TBC1D15 Gene

Protein Domains for TBC1D15 Gene


Suggested Antigen Peptide Sequences for TBC1D15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8TC07
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D15: view

No data available for Gene Families for TBC1D15 Gene

Function for TBC1D15 Gene

Molecular function for TBC1D15 Gene

UniProtKB/Swiss-Prot Function: Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).

Gene Ontology (GO) - Molecular Function for TBC1D15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with TBC1D15: view

miRNA for TBC1D15 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBC1D15 Gene

Localization for TBC1D15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D15 Gene


Subcellular locations from

Jensen Localization Image for TBC1D15 Gene COMPARTMENTS Subcellular localization image for TBC1D15 gene
Compartment Confidence
cytosol 2
endosome 2
extracellular 2
mitochondrion 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TBC1D15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TBC1D15: view

Pathways for TBC1D15 Gene

SuperPathways for TBC1D15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043087 regulation of GTPase activity ISS --
GO:0043547 positive regulation of GTPase activity ISS --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D15: view

No data available for Pathways by source for TBC1D15 Gene

Transcripts for TBC1D15 Gene

Unigene Clusters for TBC1D15 Gene

TBC1 domain family, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -

Relevant External Links for TBC1D15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D15 Gene

mRNA expression in normal human tissues for TBC1D15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D15 Gene

SOURCE GeneReport for Unigene cluster for TBC1D15 Gene Hs.284630

genes like me logo Genes that share expressions with TBC1D15: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D15 Gene

Orthologs for TBC1D15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBC1D15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBC1D15 35
  • 99.66 (n)
  • 99.71 (a)
TBC1D15 36
  • 100 (a)
(Bos Taurus)
Mammalia TBC1D15 35
  • 93.29 (n)
  • 94.79 (a)
TBC1D15 36
  • 93 (a)
(Canis familiaris)
Mammalia TBC1D15 35
  • 93.97 (n)
  • 95.37 (a)
TBC1D15 36
  • 93 (a)
(Mus musculus)
Mammalia Tbc1d15 35
  • 87.58 (n)
  • 91.65 (a)
Tbc1d15 16
Tbc1d15 36
  • 92 (a)
(Monodelphis domestica)
Mammalia TBC1D15 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D15 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Tbc1d15 35
  • 88.43 (n)
  • 93 (a)
(Gallus gallus)
Aves TBC1D15 35
  • 78.93 (n)
  • 81.38 (a)
TBC1D15 36
  • 82 (a)
(Anolis carolinensis)
Reptilia TBC1D15 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d15 35
  • 74.92 (n)
  • 74.77 (a)
(Danio rerio)
Actinopterygii tbc1d15 35
  • 65.32 (n)
  • 65.53 (a)
tbc1d15 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007911 35
  • 47.59 (n)
  • 36.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11490 36
  • 28 (a)
Tbc1d15-17 35
  • 46.1 (n)
  • 37.78 (a)
(Caenorhabditis elegans)
Secernentea tbc-15 35
  • 55.65 (n)
  • 50.42 (a)
tbc-15 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 25 (a)
GYP7 38
(Triticum aestivum)
Liliopsida Ta.12532 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4773 36
  • 42 (a)
Species with no ortholog for TBC1D15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TBC1D15 Gene

Gene Tree for TBC1D15 (if available)
Gene Tree for TBC1D15 (if available)

Paralogs for TBC1D15 Gene

Paralogs for TBC1D15 Gene

Selected SIMAP similar genes for TBC1D15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TBC1D15: view

Variants for TBC1D15 Gene

Sequence variations from dbSNP and Humsavar for TBC1D15 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs186627 -- 71,841,266(-) GCTTC(A/G)TTGCC intron-variant
rs328760 -- 71,838,327(-) GAGAT(C/T)GCGTG upstream-variant-2KB
rs328761 -- 71,838,512(-) GTCCA(C/T)TGAGG upstream-variant-2KB
rs328762 -- 71,838,556(-) GCTCC(A/G)GGGCA upstream-variant-2KB
rs328763 -- 71,840,154(-) AAGAG(C/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D15 Gene

Variant ID Type Subtype PubMed ID
dgv519e1 CNV Complex 17122850
dgv1447n71 CNV Gain 21882294
esv35030 CNV Gain 17911159
essv4115 CNV CNV 17122850
nsv818924 CNV Gain 17921354
nsv899254 CNV Loss 21882294
nsv899255 CNV Gain 21882294
nsv8988 CNV Loss 18304495
esv2657617 CNV Deletion 23128226
esv2662131 CNV Deletion 23128226
nsv518498 CNV Loss 19592680

Relevant External Links for TBC1D15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D15 Gene

Disorders for TBC1D15 Gene

Relevant External Links for TBC1D15

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TBC1D15: view

No data available for UniProtKB/Swiss-Prot for TBC1D15 Gene

Publications for TBC1D15 Gene

  1. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7. (PMID: 16055087) Zhang X.M. … Rowe T. (Biochem. Biophys. Res. Commun. 2005) 2 3
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for TBC1D15 Gene

  • antibodies-online proteins for TBC1D15
  • antibodies-online antibodies for TBC1D15
  • antibodies-online kits for TBC1D15

Sources for TBC1D15 Gene

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