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TBC1D14 Gene

protein-coding   GIFtS: 54
GCID: GC04P006910

TBC1 Domain Family, Member 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 141 2
KIAA13223 5
TBC1 Domain Family Member 142

External Ids:    HGNC: 292461   Entrez Gene: 575332   Ensembl: ENSG000001324057   OMIM: 6148555   UniProtKB: Q9P2M43   

Export aliases for TBC1D14 gene to outside databases

Previous GC identifers: GC04P006976 GC04P007029 GC04P006839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBC1D14 Gene:
TBC1D14 (TBC1 domain family, member 14) is a protein-coding gene. Diseases associated with TBC1D14 include morbid obesity, and obesity. GO annotations related to this gene include Rab GTPase activator activity and protein kinase binding. An important paralog of this gene is TBC1D12.

UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4
Function: Negative regulator of starvation-induced autophagosome formation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D14 gene promoter:
         AML1a   HSF1short   HSF1 (long)   AP-2gamma   POU3F2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D14 promoter sequence
   Search Chromatin IP Primers for TBC1D14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

TBC1D14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D14 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P006910:  view genomic region     (about GC identifiers)

Start:
6,910,969 bp from pter      End:
7,034,845 bp from pter
Size:
123,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4 (See protein sequence)
Recommended Name: TBC1 domain family member 14  
Size: 693 amino acids; 78137 Da
Subunit: Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating
activity toward these proteins
Sequence caution: Sequence=AAH41167.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA92560.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for TBC1D14:
2QQ8 (3D)    
Secondary accessions: B9A6L5 D3DVT4 E9PAZ6 Q8IW15 Q8NDK3
Alternative splicing: 2 isoforms:  Q9P2M4-1   Q9P2M4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D14: NX_Q9P2M4

Explore proteomics data for TBC1D14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001106832.1  NP_001106834.1  NP_001273734.1  NP_065824.2  

    ENSEMBL proteins: 
     ENSP00000414951   ENSP00000386921   ENSP00000411760   ENSP00000386343   ENSP00000388886  
     ENSP00000389082   ENSP00000404041   ENSP00000405875  

    TBC1D14 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q9P2M4

    ProtoNet protein and cluster: Q9P2M4

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4
    Similarity: Contains 1 Rab-GAP TBC domain


    TBC1D14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBC14_HUMAN, Q9P2M4
    Function: Negative regulator of starvation-induced autophagosome formation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI--
         
    TBC1D14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TBC1D14:
     Increased S DNA content  Increased cell size 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tbc1d14):
     mortality/aging 

    TBC1D14 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D14
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D14

    miRNA
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    miRTarBase miRNAs that target TBC1D14:
    hsa-mir-155-5p (MIRT020787), hsa-mir-320a (MIRT044844)

    Block miRNA regulation of human, mouse, rat TBC1D14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D14 (see all 32):
    hsa-miR-181c hsa-miR-548k hsa-let-7a-2* hsa-miR-181a-2* hsa-miR-374a* hsa-miR-548m hsa-miR-548a-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D14

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    GenScript: all cDNA clones in your preferred vector (see all 3): TBC1D14 (NM_001113363)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBC14_HUMAN, Q9P2M4: Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Note=After amino
    acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling
    between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole4
    golgi apparatus3
    cytosol2
    endosome2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005776autophagic vacuole IDA--
    GO:0005794Golgi apparatus IEA--

    TBC1D14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D14
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for TBC1D14 (Q9P2M41, 2, 3 ENSP000003869214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-8276559 I2D: score=2 STRING: ENSP00000381045
    RAB11BQ159071EBI-2797718,EBI-722234
    ULK1O753851EBI-2797718,EBI-908831
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010507negative regulation of autophagy IMP--
    GO:0032313regulation of Rab GTPase activity ----
    GO:2000785regulation of autophagic vacuole assembly IMP--

    TBC1D14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D14 (TBC14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TBC1D14 gene (4 alternative transcripts): 
    NM_001113361.1  NM_001113363.1  NM_001286805.1  NM_020773.2  

    Unigene Cluster for TBC1D14:

    TBC1 domain family, member 14
    Hs.518611  [show with all ESTs]
    Unigene Representative Sequence: NM_020773
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444368 ENST00000409757(uc003gjs.4) ENST00000427736 ENST00000410031
    ENST00000451522(uc010idh.3) ENST00000467966 ENST00000439515 ENST00000448507(uc011bwg.2 uc011bwh.2 uc003gju.4)
    ENST00000446947
    miRNA
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    Block miRNA regulation of human, mouse, rat TBC1D14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D14 (see all 32):
    hsa-miR-181c hsa-miR-548k hsa-let-7a-2* hsa-miR-181a-2* hsa-miR-374a* hsa-miR-548m hsa-miR-548a-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D14
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    GenScript: all cDNA clones in your preferred vector (see all 3): TBC1D14 (NM_001113363)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D14
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D14
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D14
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D14

    Additional mRNA sequence: 

    AB037743.1 AB449900.1 AK056962.1 AK295068.1 AL833868.1 BC024966.1 BC041167.1 

    19 DOTS entries:

    DT.100774883  DT.448159  DT.101983164  DT.121229434  DT.100774879  DT.95110424  DT.75145120  DT.92442389 
    DT.121229423  DT.95342390  DT.100774884  DT.101968069  DT.121229385  DT.121229395  DT.121229447  DT.95152028 
    DT.91639994  DT.92038351  DT.95322473 

    Selected AceView cDNA sequences (see all 317):

    BU623486 CN478912 AA806170 AI093353 BE328772 AI299505 AW513873 AA876133 
    F05055 F04602 AK056962 AW954153 AW118549 BE676307 AA677515 BF440005 
    BC041167 AW172771 CD172469 CA424572 BQ720363 BU175400 AA857892 BQ574684 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D14    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:        -                                         -                                                                     
    SP2:                                                                          -                                             
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for TBC1D14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D14 expression in normal human tissues (normalized intensities)      TBC1D14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAATTGC
    TBC1D14 Expression
    About this image


    TBC1D14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Testis (Reproductive System)
    TBC1D14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518611
        Custom PCR Arrays for TBC1D14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D14 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d141 , 5 TBC1 domain family, member 141, 5 86.68(n)1
    90.62(a)1
      5 (19.15 cM)5
    1008551  NM_001113362.11  NP_001106833.11 
     364906045 
    chicken
    (Gallus gallus)
    Aves TBC1D141 TBC1 domain family, member 14 80.83(n)
    92.23(a)
      422862  NM_001252314.1  NP_001239243.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    2(a)
    many ↔ many
    2(119698450-119710285)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.346922 Xenopus laevis transcribed sequence with moderate similarity more 79.82(n)    BG364189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi42a032 Transcribed sequence with weak similarity to protein more 75.6(n)    57066815 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-126
    Protein TBC-12 (tbc-12) mRNA, complete cds
    36(a)
    1 → many
    X(2525273-2532657) WBGene00044061
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYL16
    GYP56
    Putative GTPase activating protein (GAP) with a ro...
    GTPase-activating protein (GAP) for yeast Rab fami...
    9(a)
    10(a)
    many ↔ many
    many ↔ many
    XIII(647118-649280) YMR192W
    XVI(76669-79353) YPL249C


    ENSEMBL Gene Tree for TBC1D14 (if available)
    TreeFam Gene Tree for TBC1D14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D14 gene
    TBC1D122  TBC1D42  RABGAP1L2  TBC1D12  EVI52  EVI5L2  RABGAP12  
    2 SIMAP similar genes for TBC1D14 using alignment to 6 protein entries:     TBC14_HUMAN (see all proteins):
    TBC1D12    RABGAP1L

    TBC1D14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D14 (see all 2796)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716466661,2
    C--6905197(+) CCCGG-/AAT   
       CCT
    /G
    GTGGG
    2 -- int11NA 2
    rs1860481711,2
    --6909191(+) AGCCAA/GCCCAG 1 -- us2k10--------
    rs1162676781,2
    F--6909221(+) CTTTGC/TCTGGA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1899683751,2
    C--6909372(+) GTCTAC/TGCCTC 1 -- us2k10--------
    rs1822062511,2
    --6909391(+) CAGAGC/TTGAGA 1 -- us2k10--------
    rs1873140971,2
    --6909395(+) GCTGAA/GATCCA 1 -- us2k10--------
    rs1148400011,2
    C,F--6909414(+) CGCCCT/CGATCC 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs2019138041,2
    --6909491(+) CACAC-/GGGCTA 1 -- us2k10--------
    rs46895571,2
    C,F,A--6909513(+) CCGTGT/CTAATT 2 -- us2k112Minor allele frequency- C:0.31NA WA CSA EA 375
    rs1144376521,2
    C,F--6909563(+) CGTCTG/AGGCGC 2 -- us2k11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for TBC1D14 (6910969 - 7034845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TBC1D14 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727016CNV Deletion23290073
    esv2727013CNV Deletion23290073
    esv2727014CNV Deletion23290073
    esv2105831CNV Deletion18987734
    esv2727015CNV Deletion23290073
    esv1699116CNV Deletion17803354
    nsv878533CNV Loss21882294
    nsv878531CNV Loss21882294
    nsv878532CNV Loss21882294
    esv34033CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614855    OMIM disorders: --

    2 diseases for TBC1D14:    About MalaCards
    morbid obesity    obesity


    TBC1D14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBC1D14
    Human Genome Epidemiology (HuGE) Navigator: TBC1D14 (1 document)

    Export disorders for TBC1D14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D14 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TBC1D14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. TBC1D14 regulates autophagosome formation via Rab11- and ULK1- positive recycling endosomes. (PubMed id 22613832)1, 2 Longatti A.... Tooze S.A. (J. Cell Biol. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    5. First crystallographic models of human TBC domains in the context of a family-wide structural analysis. (PubMed id 18186464)1, 2 Tempel W.... Park H. (Proteins 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57533 HGNC: 29246 AceView: TBC1D14 Ensembl:ENSG00000132405 euGenes: HUgn57533
    ECgene: TBC1D14 H-InvDB: TBC1D14

    (According to HUGE)
    About This Section

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    HUGE: KIAA1322

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TBC1D14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TBC1D14 gene:
    Search GeneIP for patents involving TBC1D14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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