TBC1D14 Gene
protein-coding GIFtS: 51
GCID: GC04P006910
|
|
TBC1 domain family, member 14
| |
Aliases
for TBC1D14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 141 2 | | KIAA13221 3 | | TBC1 Domain Family Member 142 |
Export aliases for TBC1D14 gene to outside databasesPrevious GC identifers: GC04P006976 GC04P007029 GC04P006839 |
Summaries
for TBC1D14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4Function: Negative regulator of starvation-induced autophagosome formation
|
Genomic Views
for TBC1D14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBC1D14 gene promoter:
AML1a HSF1short HSF1 (long) AP-2gamma POU3F2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1TBC1D14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P006910: view genomic region
(about GC identifiers)
Start:
|
6,910,969 bp from pter |
End:
|
7,034,845 bp from pter |
Size:
|
123,877 bases |
Orientation:
|
plus strand |
|
Proteins
for TBC1D14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4 (See
protein sequence)Recommended Name: TBC1 domain family member 14 Size: 693 amino acids; 78137 Da
Subunit: Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activitytoward these proteins
Subcellular location: Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Note=After amino acidstarvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling betweenthe Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation
Sequence caution: Sequence=AAH41167.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA92560.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for TBC1D14:2QQ8 (3D)
Secondary accessions: B9A6L5 D3DVT4 E9PAZ6 Q8IW15 Q8NDK3Alternative splicing: 2 isoforms: Q9P2M4-1 Q9P2M4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TBC1D14: NX_Q9P2M4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2M4
TBC1D14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001106832.1 NP_001106834.1 NP_065824.2
ENSEMBL proteins: ENSP00000414951 ENSP00000386921 ENSP00000411760 ENSP00000386343 ENSP00000388886 ENSP00000389082 ENSP00000404041 ENSP00000405875
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TBC1D14 for ontologies About GeneDecksing
TBC1D14 Antibody Products:
Assay Products for TBC1D14: |
Protein
Domains /
Families
for TBC1D14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P2M4ProtoNet protein and cluster: Q9P2M4 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4Similarity: Contains 1 Rab-GAP TBC domain |
Function
for TBC1D14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBC14_HUMAN, Q9P2M4Function: Negative regulator of starvation-induced autophagosome formation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D14 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D14 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- | | GO:0019901 | protein kinase binding |
IPI | -- |
TBC1D14 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TBC1D14:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tbc1d14):
TBC1D14 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TBC1D14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D14
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TBC1D14 (Q9P2M42, 3 ENSP000003869214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010507 | negative regulation of autophagy |
IMP | -- | | GO:2000785 | regulation of autophagic vacuole assembly |
IMP | -- |
TBC1D14 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBC1D14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBC1D14
Search CenterWatch for drugs/clinical trials and news about TBC1D14 / TBC14
|
Transcripts
for TBC1D14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBC1D14 gene (3 alternative transcripts): NM_001113361.1 NM_001113363.1 NM_020773.2 Unigene Cluster for TBC1D14: TBC1 domain family, member 14 Hs.518611 [show with all ESTs]Unigene Representative Sequence: NM_0207739 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444368 ENST00000409757(uc003gjs.4) ENST00000427736 ENST00000410031
ENST00000451522(uc010idh.3) ENST00000467966 ENST00000439515 ENST00000448507(uc011bwg.2 uc011bwh.2 uc003gju.4)
ENST00000446947
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D14 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D14 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TBC1D14 (NM_001113363) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D14 |
Additional cDNA sequence: AB037743.1 AB449900.1 AK056962.1 AK091893.1 AK295068.1 AL833868.1 BC024966.1 BC041167.1 20 DOTS entries: DT.100774883 DT.448159 DT.101983164 DT.121229434 DT.100774879 DT.95110424 DT.75145120 DT.92442389 DT.99933254 DT.121229423 DT.95342390 DT.100774884 DT.101968069 DT.121229385 DT.121229395 DT.121229447 DT.95152028 DT.91639994 DT.92038351 DT.95322473 24/317 AceView cDNA sequences (see all 317): Z38773 AI299505 AI246009 F05055 BU623486 BG623689 AW503868 AA705475 BQ001226 AA291139 AW769993 BQ216261 AA573858 AA059019 AI090231 AI927241 BQ894090 AA876133 F04602 AW118549 BE676307 AK056962 AA677515 AW172771
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D14 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TBC1D14
|
Expression
for TBC1D14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTAATTGC
About this image
See TBC1D14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBC1D14
SOURCE GeneReport for Unigene cluster: Hs.518611
SABiosciences Custom PCR Arrays for TBC1D14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D14
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D14 |
Orthologs
for TBC1D14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBC1D14 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TBC1D141 |
TBC1 domain family, member 14 |
80.83(n)
92.23(a) |
|
422862 NM_001252314.1 NP_001239243.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.346922 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.82(n) |
|
BG364189.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi42a032 |
Transcribed sequence with weak similarity to protein more |
75.6(n) |
|
57066815 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
35(a) |
1 → many |
Group10.20(373948-375807) |
worm
(Caenorhabditis elegans) |
Secernentea |
tbc-126 |
TBC (Tre-2/Bub2/Cdc16) domain family member (tbc-1... |
31(a) |
1 → many |
X(2525715-2532650) |
ENSEMBL Gene Tree for TBC1D14 (if available)
TreeFam Gene Tree for TBC1D14 (if available) |
Paralogs
for TBC1D14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBC1D14 gene
- RABGAP1L2 TBC1D122 TBC1D42 TBC1D12 EVI52 EVI5L2 RABGAP12
2 SIMAP similar genes for TBC1D14 using alignment to 6 protein entries: TBC14_HUMAN (see all proteins):TBC1D12 RABGAP1L
TBC1D14 for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TBC1D14
3 CNVs: 36291 3478 47919
1 Indel: 46682 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D14 |
|
Disorders
/ Diseases
for TBC1D14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D14 for disorders About GeneDecksing
OMIM gene information: 614855
OMIM disorders: --
2  diseases for TBC1D14: About MalaCardsmorbid obesity obesity
Human Genome Epidemiology (HuGE) Navigator: TBC1D14 (1 document)
Export disorders for TBC1D14 gene to outside databases
|
Publications
for TBC1D14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D14 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TBC1D14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- TBC1D14 regulates autophagosome formation via Rab11- a nd ULK1-positive recycling endosomes. (PubMed id 22613832)1, 2 Longatti A....Tooze S.A. (2012)
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (2009)
- First crystallographic models of human TBC domains in the context of a family-wide structural analysis. (PubMed id 18186464)1, 2 Tempel W.... Park H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
|
External Searches for TBC1D14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D14 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TBC1D14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D14 gene:
Search GeneIP for patents involving TBC1D14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D14 |
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