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Aliases for TBC1D13 Gene

Aliases for TBC1D13 Gene

  • TBC1 Domain Family, Member 13 2 3

External Ids for TBC1D13 Gene

Summaries for TBC1D13 Gene

GeneCards Summary for TBC1D13 Gene

TBC1D13 (TBC1 Domain Family, Member 13) is a Protein Coding gene. An important paralog of this gene is TBC1D5.

UniProtKB/Swiss-Prot for TBC1D13 Gene

  • May act as a GTPase-activating protein for Rab family protein(s)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D13 Gene

Genomics for TBC1D13 Gene

Genomic Location for TBC1D13 Gene

Start:
128,787,204 bp from pter
End:
128,810,432 bp from pter
Size:
23,229 bases
Orientation:
Plus strand

Genomic View for TBC1D13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D13 Gene

Regulatory Elements for TBC1D13 Gene

Proteins for TBC1D13 Gene

  • Protein details for TBC1D13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVG8-TBC13_HUMAN
    Recommended name:
    TBC1 domain family member 13
    Protein Accession:
    Q9NVG8
    Secondary Accessions:
    • A7E2E7
    • B3KW04
    • B9EGJ8
    • Q5T270
    • Q5T271

    Protein attributes for TBC1D13 Gene

    Size:
    400 amino acids
    Molecular mass:
    46554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D13 Gene

Proteomics data for TBC1D13 Gene at MOPED

Post-translational modifications for TBC1D13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBC1D13 Gene

Domains for TBC1D13 Gene

Protein Domains for TBC1D13 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TBC13_HUMAN
Domain:
  • Contains 1 Rab-GAP TBC domain.:
    • Q9NVG8
genes like me logo Genes that share domains with TBC1D13: view

No data available for Gene Families for TBC1D13 Gene

Function for TBC1D13 Gene

Molecular function for TBC1D13 Gene

UniProtKB/Swiss-Prot Function: May act as a GTPase-activating protein for Rab family protein(s)

Gene Ontology (GO) - Molecular Function for TBC1D13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TBC1D13: view

miRNA for TBC1D13 Gene

miRTarBase miRNAs that target TBC1D13

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBC1D13 Gene

Localization for TBC1D13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D13 Gene COMPARTMENTS Subcellular localization image for TBC1D13 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TBC1D13 Gene

Pathways for TBC1D13 Gene

SuperPathways for TBC1D13 Gene

No Data Available

Interacting Proteins for TBC1D13 Gene

Gene Ontology (GO) - Biological Process for TBC1D13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D13: view

No data available for Pathways by source for TBC1D13 Gene

Transcripts for TBC1D13 Gene

Unigene Clusters for TBC1D13 Gene

TBC1 domain family, member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:
SP7: -

Relevant External Links for TBC1D13 Gene

GeneLoc Exon Structure for
TBC1D13
ECgene alternative splicing isoforms for
TBC1D13

Expression for TBC1D13 Gene

mRNA expression in normal human tissues for TBC1D13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D13 Gene

SOURCE GeneReport for Unigene cluster for TBC1D13 Gene Hs.3376

genes like me logo Genes that share expressions with TBC1D13: view

Orthologs for TBC1D13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBC1D13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D13 36
  • 99.67 (n)
  • 99.75 (a)
TBC1D13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D13 36
  • 92.31 (n)
  • 96.24 (a)
TBC1D13 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D13 36
  • 91.75 (n)
  • 96.5 (a)
TBC1D13 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d13 36
  • 90.25 (n)
  • 97.5 (a)
Tbc1d13 16
Tbc1d13 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D13 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D13 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d13 36
  • 90.08 (n)
  • 96 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 90 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
TBC1D13 36
  • 80.2 (n)
  • 90.73 (a)
lizard
(Anolis carolinensis)
Reptilia TBC1D13 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20440 36
tbc1d13 36
  • 74.58 (n)
  • 82.5 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26923 36
tbc1d13 36
  • 75.3 (n)
  • 80.05 (a)
TBC1D13 37
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005738 36
  • 61.08 (n)
  • 55.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta GAPsec 36
  • 56.41 (n)
  • 53.59 (a)
GAPsec 37
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbc-13 36
  • 53.32 (n)
  • 48.21 (a)
tbc-13 37
  • 37 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G04830 36
  • 48.77 (n)
  • 42.94 (a)
rice
(Oryza sativa)
Liliopsida Os01g0908100 36
  • 51.54 (n)
  • 45.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1952.17c 36
  • 47.95 (n)
  • 44.1 (a)
Species with no ortholog for TBC1D13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D13 Gene

ENSEMBL:
Gene Tree for TBC1D13 (if available)
TreeFam:
Gene Tree for TBC1D13 (if available)

Paralogs for TBC1D13 Gene

Paralogs for TBC1D13 Gene

Selected SIMAP similar genes for TBC1D13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBC1D13: view

Variants for TBC1D13 Gene

Sequence variations from dbSNP and Humsavar for TBC1D13 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs15676 -- 128,809,748(-) CTGCT(C/T)GAAAA utr-variant-3-prime
rs1572912 - 128,803,275(-) ATGGC(A/G)CAGAG intron-variant, missense, reference
rs1572913 -- 128,803,031(-) TGggc(A/G)ggcca intron-variant
rs1891076 -- 128,788,443(-) CTGCT(C/G)TAGGG intron-variant
rs2282394 -- 128,791,076(-) CACCT(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D13 Gene

Variant ID Type Subtype PubMed ID
nsv893901 CNV Loss 21882294
nsv893902 CNV Gain 21882294
dgv8296n71 CNV Loss 21882294
esv2662893 CNV Deletion 23128226
esv2739076 CNV Deletion 23290073
nsv893904 CNV Loss 21882294
esv2671842 CNV Deletion 23128226
nsv521120 CNV Loss 19592680
dgv8297n71 CNV Loss 21882294

Relevant External Links for TBC1D13 Gene

HapMap Linkage Disequilibrium report
TBC1D13

Disorders for TBC1D13 Gene

No disorders were found for TBC1D13 Gene.

No data available for UniProtKB/Swiss-Prot for TBC1D13 Gene

Publications for TBC1D13 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  3. TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. (PMID: 22762500) Davey J.R. … StAPckli J. (Traffic 2012) 2 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for TBC1D13 Gene

Sources for TBC1D13 Gene

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