Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TBC1D12 Gene

protein-coding   GIFtS: 40
GCID: GC10P096152

TBC1 Domain Family, Member 12

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TBC1 Domain Family, Member 121 2
TBC1 Domain Family Member 122
KIAA06083

External Ids:    HGNC: 290821   Entrez Gene: 232322   Ensembl: ENSG000001082397   UniProtKB: O603473   

Export aliases for TBC1D12 gene to outside databases

Previous GC identifers: GC10P095827 GC10P089788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TBC1D12 Gene:
TBC1D12 (TBC1 domain family, member 12) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D4.

UniProtKB/Swiss-Prot: TBC12_HUMAN, O60347
Function: May act as a GTPase-activating protein for Rab family protein(s)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D12 gene promoter:
         TBP   RFX1   Pax-5   c-Myb   AP-4   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TBC1D12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23.33

TBC1D12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D12 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P096152:  view genomic region     (about GC identifiers)

Start:
96,162,186 bp from pter      End:
96,296,089 bp from pter
Size:
133,904 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TBC12_HUMAN, O60347 (See protein sequence)
Recommended Name: TBC1 domain family member 12  
Size: 775 amino acids; 85626 Da
Sequence caution: Sequence=BAA25534.1; Type=Erroneous initiation; Sequence=CAB43225.2; Type=Erroneous initiation;
Secondary accessions: Q5VYA6 Q8WX26 Q8WX59 Q9UG83

Explore the universe of human proteins at neXtProt for TBC1D12: NX_O60347

Explore proteomics data for TBC1D12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056003.1  
    ENSEMBL proteins: 
     ENSP00000225235  

    TBC1D12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TBC1D12
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TBC1D12
    GenScript Custom Purified and Recombinant Proteins Services for TBC1D12
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBC1D12

     
    Search eBioscience for Proteins for TBC1D12 

    TBC1D12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TBC1D12
    Novus Biologicals TBC1D12 Antibodies
    Abcam antibodies for TBC1D12
    Cloud-Clone Corp. Antibodies for TBC1D12
    Search ThermoFisher Antibodies for TBC1D12
    Search LSBio for Antibodies for TBC1D12

    TBC1D12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TBC1D12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TBC1D12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBC1D12
    Cloud-Clone Corp. CLIAs for TBC1D12
    Search eBioscience for ELISAs for TBC1D12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry O60347

    ProtoNet protein and cluster: O60347

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TBC12_HUMAN, O60347
    Similarity: Contains 1 Rab-GAP TBC domain


    Find genes that share domains with TBC1D12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBC12_HUMAN, O60347
    Function: May act as a GTPase-activating protein for Rab family protein(s)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
         
    Find genes that share ontologies with TBC1D12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBC1D12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D12

    miRNA
    Products:
        
    miRTarBase miRNAs that target TBC1D12:
    hsa-mir-101-3p (MIRT027356), hsa-mir-103a-3p (MIRT027209), hsa-mir-22-3p (MIRT030637)

    Block miRNA regulation of human, mouse, rat TBC1D12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D12 (see all 88):
    hsa-miR-548j hsa-miR-579 hsa-miR-642a hsa-miR-607 hsa-miR-519a hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-376c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TBC1D12
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TBC1D12

    Clone
    Products:
         
    OriGene clones in human, mouse for TBC1D12 (see all 6)
    OriGene ORF clones in mouse, rat for TBC1D12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBC1D12 (NM_015188)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D12
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TBC1D12

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TBC1D12
    Browse ESI BIO Cell Lines and PureStem Progenitors for TBC1D12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D12
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D12

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    Find genes that share ontologies with TBC1D12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D12 (TBC12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TBC1D12 gene: 
    NM_015188.1  

    Unigene Cluster for TBC1D12:

    TBC1 domain family, member 12
    Hs.500598  [show with all ESTs]
    Unigene Representative Sequence: NM_015188
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225235(uc001kjr.2) ENST00000485048 ENST00000457045
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBC1D12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D12 (see all 88):
    hsa-miR-548j hsa-miR-579 hsa-miR-642a hsa-miR-607 hsa-miR-519a hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-376c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TBC1D12
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D12
    Clone
    Products:
         
    OriGene clones in human, mouse for TBC1D12 (see all 6)
    OriGene ORF clones in mouse, rat for TBC1D12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBC1D12 (NM_015188)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D12
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TBC1D12
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D12
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D12
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D12

    Additional mRNA sequence: 

    AB011180.1 AB449898.1 AJ404330.1 AK090865.1 AL049956.1 BC064323.1 

    4 DOTS entries:

    DT.85105340  DT.97771689  DT.100772148  DT.95371392 

    Selected AceView cDNA sequences (see all 96):

    AI684784 AW662906 AA346633 AW948925 BX105596 BF061886 CB053712 AI733561 
    AW451225 BE768105 BM670728 Z45049 AI277581 F04292 BU686951 AW952386 
    BC064323 Z42723 BG260325 AB011180 AA424602 AL703252 F08056 AA693384 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TBC1D12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTGTTTC
    TBC1D12 Expression
    About this image

    TBC1D12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500598
        Custom PCR Arrays for TBC1D12
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D12
    QuantiTect SYBR Green Assays in human, mouse, rat TBC1D12
    QuantiFast Probe-based Assays in human, mouse, rat TBC1D12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d121 , 5 TBC1D12: TBC1 domain family, member 121, 5 85.24(n)1
    85.53(a)1
      19 (33.47 cM)5
    2094781  NM_145952.31  NP_666064.31 
     388365795 
    chicken
    (Gallus gallus)
    Aves TBC1D121 TBC1 domain family, member 12 78.26(n)
    81.61(a)
      768541  XM_001231527.3  XP_001231528.2 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D126
    TBC1 domain family, member 12
    91(a)
    1 ↔ 1
    GL343219.1(1266016-1303090)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL891833.22   -- 80(n)    AL891833.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tbc1d12b1 TBC1 domain family, member 12b 67.94(n)
    74.9(a)
      100332088  XM_002663912.3  XP_002663958.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-126
    Protein TBC-12 (tbc-12) mRNA, complete cds
    33(a)
    1 → many
    X(2525273-2532657) WBGene00044061
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP56
    GYL16
    GTPase-activating protein (GAP) for yeast Rab fami...
    Putative GTPase activating protein (GAP) with a ro...
    8(a)
    10(a)
    many ↔ many
    many ↔ many
    XVI(76669-79353) YPL249C
    XIII(647118-649280) YMR192W


    ENSEMBL Gene Tree for TBC1D12 (if available)
    TreeFam Gene Tree for TBC1D12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TBC1D12 gene
    TBC1D42  TBC1D142  RABGAP1L2  TBC1D12  EVI52  EVI5L2  RABGAP12  
    1 SIMAP similar gene for TBC1D12 using alignment to 2 protein entries:     TBC12_HUMAN (see all proteins):
    TBC1D14

    Find genes that share paralogs with TBC1D12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TBC1D12
    PGOHUM00000242158


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TBC1D12 (see all 2446)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357995191,2
    C--89870596(+) TTTTT-/T/TT  
            
    GAGGT
    1 -- int11NA 2
    rs1490363351,2
    --96160410(+) CATTTC/TATTAT 1 -- us2k10--------
    rs1430758671,2
    C--96160411(+) ATTTTA/GTTATA 1 -- us2k10--------
    rs587763361,2
    C,F--96160574(+) TATATA/GCTTTT 1 -- us2k12Minor allele frequency- G:0.09WA 120
    rs1814562231,2
    --96160678(+) GAAACA/CTTTGG 1 -- us2k10--------
    rs1865723571,2
    --96160812(+) TTTTAC/TTATTT 1 -- us2k10--------
    rs1903438571,2
    --96161409(+) TGACCA/GCTTCC 1 -- us2k10--------
    rs1482327331,2
    --96161484(+) CTGGAC/GTGCAG 1 -- us2k10--------
    rs1419344041,2
    --96161485(+) TGGAGA/TGCAGT 1 -- us2k10--------
    rs1815960741,2
    --96161613(+) TATTTC/TTAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBC1D12 (96162186 - 96296089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TBC1D12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4632CNV Deletion18987735
    esv5036CNV Deletion18987735
    esv2658991CNV Deletion23128226
    esv2673369CNV Deletion23128226
    esv2664667CNV Deletion23128226
    esv2739684CNV Deletion23290073
    esv2739696CNV Deletion23290073
    nsv831946CNV Loss17160897
    esv25061CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D12
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TBC1D12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TBC1D12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    5. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23232 HGNC: 29082 AceView: TBC1D12 Ensembl:ENSG00000108239 euGenes: HUgn23232
    ECgene: TBC1D12 H-InvDB: TBC1D12

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0608

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TBC1D12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TBC1D12 gene:
    Search GeneIP for patents involving TBC1D12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TBC1D12  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TBC1D12  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TBC1D12  
     OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TBC1D12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TBC1D12   OriGene Custom Protein Services for TBC1D12  

     
     
     Block miRNA regulation of human, mouse, rat TBC1D12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TBC1D12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D12 Predesigned siRNA for gene silencing in human, mouse, rat TBC1D12
     QuantiFast Probe-based Assays in human, mouse, rat TBC1D12 QuantiTect SYBR Green Assays in human, mouse, rat TBC1D12
     Custom PCR Arrays for TBC1D12 Search Chromatin IP Primers for TBC1D12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D12  Search GeneGlobe Interaction Network for TBC1D12
     Regulatory tfbs in TBC1D12 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TBC1D12 GenScript cDNA clones with any tag delivered in your preferred vector for TBC1D12
     GenScript Custom Assay Services for TBC1D12 GenScript Custom overexpressing Cell Line Services for TBC1D12
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TBC1D12 (TBC12)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TBC1D12 antibodies
     Antibodies for TBC1D12
     See all of Abcam's Antibodies, Kits and Proteins for TBC1D12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TBC1D12
     Antibodies for TBC1D12
     ELISAs for TBC1D12
     CLIAs for TBC1D12



     Browse ESI BIO Cell Lines and PureStem Progenitors for TBC1D12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D12
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TBC1D12
     Browse SwitchGear Promoter luciferase reporter plasmids for TBC1D12
     Search ThermoFisher Antibodies for TBC1D12
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TBC1D12
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D12
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBC1D12
     Search LSBio for Antibodies for TBC1D12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TBC1D12
      Search eBioscience for proteins for TBC1D12
      Search eBioscience for elisas for TBC1D12
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TBC1D12 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4