Aliases for TBC1D10C Gene
External Ids for TBC1D10C Gene
Previous GeneCards Identifiers for TBC1D10C Gene
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
GeneCards Summary for TBC1D10C Gene
TBC1D10C (TBC1 Domain Family Member 10C) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and TBC/RABGAPs. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D10B.
UniProtKB/Swiss-Prot for TBC1D10C Gene
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.