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Aliases for TBC1D10C Gene

Aliases for TBC1D10C Gene

  • TBC1 Domain Family, Member 10C 2 3
  • Carabin 3 6
  • TBC1 Domain Family Member 10C 4
  • EPI64C 3

External Ids for TBC1D10C Gene

Summaries for TBC1D10C Gene

Entrez Gene Summary for TBC1D10C Gene

  • The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for TBC1D10C Gene

TBC1D10C (TBC1 Domain Family, Member 10C) is a Protein Coding gene. An important paralog of this gene is TBC1D10B.

UniProtKB/Swiss-Prot for TBC1D10C Gene

  • Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D10C Gene

Genomics for TBC1D10C Gene

Genomic Location for TBC1D10C Gene

Start:
67,403,797 bp from pter
End:
67,410,090 bp from pter
Size:
6,294 bases
Orientation:
Plus strand

Genomic View for TBC1D10C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D10C Gene

Regulatory Elements for TBC1D10C Gene

Transcription factor binding sites by QIAGEN in the TBC1D10C gene promoter:

Proteins for TBC1D10C Gene

  • Protein details for TBC1D10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV04-TB10C_HUMAN
    Recommended name:
    Carabin
    Protein Accession:
    Q8IV04
    Secondary Accessions:
    • G3V1D6

    Protein attributes for TBC1D10C Gene

    Size:
    446 amino acids
    Molecular mass:
    49712 Da
    Quaternary structure:
    • Interacts with both calcineurin and HRAS.

    Alternative splice isoforms for TBC1D10C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D10C Gene

Proteomics data for TBC1D10C Gene at MOPED

Post-translational modifications for TBC1D10C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys347

Other Protein References for TBC1D10C Gene

No data available for DME Specific Peptides for TBC1D10C Gene

Domains for TBC1D10C Gene

Protein Domains for TBC1D10C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D10C Gene

Graphical View of Domain Structure for InterPro Entry

Q8IV04

UniProtKB/Swiss-Prot:

TB10C_HUMAN
Domain:
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.:
    • Q8IV04
  • Contains 1 Rab-GAP TBC domain.:
    • Q8IV04
genes like me logo Genes that share domains with TBC1D10C: view

No data available for Gene Families for TBC1D10C Gene

Function for TBC1D10C Gene

Molecular function for TBC1D10C Gene

UniProtKB/Swiss-Prot Function: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.

Gene Ontology (GO) - Molecular Function for TBC1D10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBC1D10C: view

Phenotypes for TBC1D10C Gene

genes like me logo Genes that share phenotypes with TBC1D10C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TBC1D10C Gene

Localization for TBC1D10C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D10C Gene COMPARTMENTS Subcellular localization image for TBC1D10C gene
Compartment Confidence
cytosol 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for TBC1D10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 17562788
GO:0016020 membrane IDA 19946888
GO:0031527 filopodium membrane IDA 17562788
genes like me logo Genes that share ontologies with TBC1D10C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D10C Gene

Pathways for TBC1D10C Gene

SuperPathways for TBC1D10C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IMP 17562788
GO:0043547 positive regulation of GTPase activity IEA --
GO:0050869 negative regulation of B cell activation IEA --
GO:0051534 negative regulation of NFAT protein import into nucleus IEA --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with TBC1D10C: view

No data available for Pathways by source for TBC1D10C Gene

Transcripts for TBC1D10C Gene

Unigene Clusters for TBC1D10C Gene

TBC1 domain family, member 10C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for TBC1D10C Gene

GeneLoc Exon Structure for
TBC1D10C
ECgene alternative splicing isoforms for
TBC1D10C

Expression for TBC1D10C Gene

mRNA expression in normal human tissues for TBC1D10C Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D10C Gene

This gene is overexpressed in Whole Blood (27.2) and Spleen (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D10C Gene

SOURCE GeneReport for Unigene cluster for TBC1D10C Gene Hs.534648

mRNA Expression by UniProt/SwissProt for TBC1D10C Gene

Q8IV04-TB10C_HUMAN
Tissue specificity: Most abundant in spleen and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TBC1D10C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TBC1D10C Gene

Orthologs for TBC1D10C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D10C 35
  • 96.19 (n)
  • 95.74 (a)
TBC1D10C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D10C 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D10C 35
  • 88.12 (n)
  • 93.27 (a)
TBC1D10C 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d10c 35
  • 84.01 (n)
  • 88.51 (a)
Tbc1d10c 16
Tbc1d10c 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D10C 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d10c 35
  • 84.08 (n)
  • 89.01 (a)
lizard
(Anolis carolinensis)
Reptilia TBC1D10C 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101887140 35
  • 55.59 (n)
  • 49.71 (a)
TBC1D10C 36
  • 14 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wkd 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-10 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSB3 36
  • 16 (a)
ManyToMany
MSB4 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6221 36
  • 40 (a)
OneToMany
Species with no ortholog for TBC1D10C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D10C Gene

ENSEMBL:
Gene Tree for TBC1D10C (if available)
TreeFam:
Gene Tree for TBC1D10C (if available)

Paralogs for TBC1D10C Gene

Paralogs for TBC1D10C Gene

Selected SIMAP similar genes for TBC1D10C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TBC1D10C: view

Variants for TBC1D10C Gene

Sequence variations from dbSNP and Humsavar for TBC1D10C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15578 -- 67,410,000(+) ACAAG(A/C/T)ACCAA utr-variant-3-prime, nc-transcript-variant
rs1638586 -- 67,407,126(+) GGTGT(A/G)CCGAA intron-variant
rs1638587 -- 67,410,326(+) GGGCG(C/T)CCCAG downstream-variant-500B
rs1790749 -- 67,408,736(-) TGTCG(C/T)CTCCC intron-variant
rs1790750 -- 67,407,109(-) TGTGA(C/T)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D10C Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv516453 CNV Loss 19592680
dgv1195n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294
nsv521723 CNV Loss 19592680

Relevant External Links for TBC1D10C Gene

HapMap Linkage Disequilibrium report
TBC1D10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D10C Gene

Disorders for TBC1D10C Gene

Relevant External Links for TBC1D10C

Genetic Association Database (GAD)
TBC1D10C
Human Genome Epidemiology (HuGE) Navigator
TBC1D10C
genes like me logo Genes that share disorders with TBC1D10C: view

No data available for UniProtKB/Swiss-Prot for TBC1D10C Gene

Publications for TBC1D10C Gene

  1. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. (PMID: 17230191) Pan F. … Liu J.O. (Nature 2007) 2 3 4
  2. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. (PMID: 20404108) Hsu C. … Simons M. (J. Cell Biol. 2010) 2 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity. (PMID: 23109291) Schickel J.N. … Soulas-Sprauel P. (EMBO Mol Med 2012) 3

Products for TBC1D10C Gene

Sources for TBC1D10C Gene

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