TBC1D10C Gene
protein-coding GIFtS: 49
GCID: GC11P067171
|
|
TBC1 domain family, member 10C
| |
Aliases
for TBC1D10C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 10C1 2 | | FLJ003321 | | EPI64C1 2 | | Carabin1 | | CARABIN2 5 | | TBC1 Domain Family Member 10C3 | | Carabin1 | | |
Export aliases for TBC1D10C gene to outside databasesPrevious GC identifers: GC11P066929 GC11P063500 |
Summaries
for TBC1D10C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBC1D10C:
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus forcalcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calciumand calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2013)
UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04Function: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Actsas a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurinand Ras
|
Genomic Views
for TBC1D10C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBC1D10C gene promoter:
HEN1 p53 Sp1 ARP-1 Lmo2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D10C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D10C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.1TBC1D10C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P067171: view genomic region
(about GC identifiers)
Start:
|
67,171,386 bp from pter |
End:
|
67,177,560 bp from pter |
Size:
|
6,175 bases |
Orientation:
|
plus strand |
|
Proteins
for TBC1D10C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04 (See
protein sequence)Recommended Name: Carabin Size: 446 amino acids; 49712 Da
Subunit: Interacts with both calcineurin and HRAS
Secondary accessions: G3V1D6Alternative splicing: 2 isoforms: Q8IV04-1 Q8IV04-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TBC1D10C: NX_Q8IV04
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IV04
TBC1D10C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243437.1 NP_940919.1
ENSEMBL proteins: ENSP00000435543 ENSP00000435829 ENSP00000443654 ENSP00000310193
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TBC1D10C for ontologies About GeneDecksing
TBC1D10C Antibody Products:
Assay Products for TBC1D10C: |
Protein
Domains /
Families
for TBC1D10C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D10C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IV04ProtoNet protein and cluster: Q8IV04 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04Similarity: Contains 1 Rab-GAP TBC domain |
Function
for TBC1D10C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04Function: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Actsas a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurinand Ras
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D10C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
TBC1D10C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TBC1D10C:
|
Pathways & Interactions
for TBC1D10C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D10C
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TBC1D10C (Q8IV043 ENSP000003101934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TBC1D10C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBC1D10C
Search CenterWatch for drugs/clinical trials and news about TBC1D10C / TB10C
|
Transcripts
for TBC1D10C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBC1D10C gene (2 alternative transcripts): NM_001256508.1 NM_198517.3 Unigene Cluster for TBC1D10C: TBC1 domain family, member 10C Hs.534648 [show with all ESTs]Unigene Representative Sequence: AK1261319 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000526387(uc001okz.3) ENST00000530967 ENST00000529635(uc001olb.3)
ENST00000542590 ENST00000533745 ENST00000529132 ENST00000526474 ENST00000524662
ENST00000312390(uc001ola.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D10C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D10C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AK126131.1 BC022202.1 BC035630.1 BC036873.1 BC047319.1 BC062999.1 BC127792.1 NR_046266.1 8 DOTS entries: DT.100673427 DT.120703563 DT.100773238 DT.101976083 DT.101983129 DT.95274692 DT.100736554 DT.91685027 24/85 AceView cDNA sequences (see all 85): BC047319 BX443220 AK126131 BM561466 BM916985 BI906461 BC062999 AI471891 BX360320 BX282482 BM564103 BQ052902 NM_198517 CR610401 BM918191 BI837186 BQ084220 AK122585 BM919968 BQ053995 BI821762 AI246193 AW512177 BI909849
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10C (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | - | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TBC1D10C
|
Expression
for TBC1D10C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D10C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACCGTCCT
About this image
See TBC1D10C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBC1D10C
SOURCE GeneReport for Unigene cluster: Hs.534648
UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04Tissue specificity: Most abundant in spleen and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for TBC1D10C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D10C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBC1D10C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D10C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D10C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10C |
Orthologs
for TBC1D10C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBC1D10C gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TBC1D10C6 |
-- |
61(a) |
1 ↔ 1 |
1(93168091-93180967) |
zebrafish
(Danio rerio) |
Actinopterygii |
BX324205.16 |
-- |
14(a) |
1 ↔ 1 |
14(22909158-22926271) |
fruit fly
(Drosophila melanogaster) |
Insecta |
wkd6 |
whacked |
42(a) |
1 → many |
3R(7407301-7411027) |
worm
(Caenorhabditis elegans) |
Secernentea |
tbc-196tbc-106 |
--TBC (Tre-2/Bub2/Cdc16) domain family member (tbc-1... |
7(a)29(a) |
possible ortholog1 ↔ many |
X(14002950-14012526) III(977375-988437) |
ENSEMBL Gene Tree for TBC1D10C (if available)
TreeFam Gene Tree for TBC1D10C (if available) |
Paralogs
for TBC1D10C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBC1D10C gene
- TBC1D3H2 SGSM32 TBC1D2B2 TBC1D3C2 GRTP12 TBC1D10B2 TBC1D32 TBC1D3F2
- TBC1D262 ENSG000002487512 TBC1D10A2 TBC1D22 TBC1D3G2 USP6NL2 TBC1D282 TBC1D3B2
11 SIMAP similar genes for TBC1D10C using alignment to 3 protein entries: TB10C_HUMAN (see all proteins):FLJ00332 FLJ00288 TBC1D10B TBC1D10A dJ130H16.2 EVI5
TBC1D3B TBC1D3C TBC1D3F TBC1D3G TBC1D3H
TBC1D10C for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D10C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBC1D10C (67171386 - 67177560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TBC1D10C
1 CNV: 48873 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D10C |
|
Disorders
/ Diseases
for TBC1D10C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D10C for disorders About GeneDecksing
OMIM gene information: 610831
OMIM disorders: --
1  disease for TBC1D10C: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: TBC1D10C (3 documents)
Export disorders for TBC1D10C gene to outside databases
|
Publications
for TBC1D10C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D10C gene integrated from 9 sources:
(articles sorted by number of sources associating them with TBC1D10C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. (PubMed id 17230191)1, 2, 3 Pan F.... Liu J.O. (2007)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Regulation of exosome secretion by Rab35 and its GTPa se-activating proteins TBC1D10A-C. (PubMed id 20404108)1 Hsu C....Simons M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Calcineurin inhibitors activate the proto-oncogene Ra s and promote protumorigenic signals in renal cancer cells. (PubMed id 19903851)1 Datta D....Pal S. (2009)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TBC1D10C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D10C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D10C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D10C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D10C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D10C gene:
Search GeneIP for patents involving TBC1D10C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D10C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBC1D10C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D10C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D10C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBC1D10C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D10C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D10C |
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 | | | TBC1D10C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10C |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D10C |
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