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Aliases for TBC1D10C Gene

Aliases for TBC1D10C Gene

  • TBC1 Domain Family Member 10C 2 3 4 5
  • TBC1 Domain Family, Member 10C 2
  • CARABIN 3
  • EPI64C 3

External Ids for TBC1D10C Gene

Previous GeneCards Identifiers for TBC1D10C Gene

  • GC11P066929
  • GC11P067171
  • GC11P063500

Summaries for TBC1D10C Gene

Entrez Gene Summary for TBC1D10C Gene

  • The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for TBC1D10C Gene

TBC1D10C (TBC1 Domain Family Member 10C) is a Protein Coding gene. Among its related pathways are Immune System and Vesicle-mediated transport. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D10A.

UniProtKB/Swiss-Prot for TBC1D10C Gene

  • Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D10C Gene

Genomics for TBC1D10C Gene

Regulatory Elements for TBC1D10C Gene

Enhancers for TBC1D10C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F067347 1.3 Ensembl ENCODE 11.7 -54.6 -54586 2.6 PKNOX1 ARNT CREB3L1 ARID4B ZNF48 YY1 ELK1 GATA2 JUNB NCOA1 ENSG00000258297 ENSG00000256514 CLCF1 RBM4B RAD9A RNU6-1238P TBC1D10C SSH3 CARNS1 PPP1CA
GH11F066542 1.4 Ensembl ENCODE 10.3 -857.7 -857694 6.2 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ACTN3 CTSF DPP3 CTSW TBC1D10C RIN1 ZDHHC24 GC11M066536
GH11F067378 1.3 Ensembl ENCODE 10.6 -23.0 -22986 5.0 HDGF ATF1 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF48 ZNF2 ZNF121 PTPRCAP CARNS1 SSH3 POLD4 PPP1CA RPS6KB2 ENSG00000255949 RBM4B TBC1D10C RAD9A
GH11F067310 1.3 Ensembl ENCODE 10.5 -91.1 -91106 4.4 HDGF PKNOX1 ARNT ARID4B SIN3A GATA2 ZNF143 FOS DEK JUNB RHOD PTPRCAP TBC1D10C RAD9A CARNS1 RIN1 LOC100130987 SSH3
GH11F067344 1.2 Ensembl ENCODE 11.3 -57.9 -57935 3.1 PKNOX1 SIN3A ZBTB40 ZNF2 RAD21 ELK1 ZNF366 ZNF143 RCOR1 FOS RBM4B ENSG00000256514 CLCF1 SSH3 ANKRD13D RAD9A PPP1CA RNU6-1238P TBC1D10C CARNS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TBC1D10C on UCSC Golden Path with GeneCards custom track

Promoters for TBC1D10C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769448 814 1401 HDGF ELF3 TBL1XR1 ZBTB40 EGR1 ZNF143 ETV6 EGR2 ZBTB2 SP5

Genomic Location for TBC1D10C Gene

Chromosome:
11
Start:
67,403,686 bp from pter
End:
67,410,090 bp from pter
Size:
6,405 bases
Orientation:
Plus strand

Genomic View for TBC1D10C Gene

Genes around TBC1D10C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D10C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D10C Gene

Proteins for TBC1D10C Gene

  • Protein details for TBC1D10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV04-TB10C_HUMAN
    Recommended name:
    Carabin
    Protein Accession:
    Q8IV04
    Secondary Accessions:
    • G3V1D6

    Protein attributes for TBC1D10C Gene

    Size:
    446 amino acids
    Molecular mass:
    49712 Da
    Quaternary structure:
    • Interacts with both calcineurin and HRAS.

    Alternative splice isoforms for TBC1D10C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D10C Gene

Post-translational modifications for TBC1D10C Gene

  • Ubiquitination at Lys 347
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TBC1D10C Gene

Domains & Families for TBC1D10C Gene

Protein Domains for TBC1D10C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D10C Gene

Graphical View of Domain Structure for InterPro Entry

Q8IV04

UniProtKB/Swiss-Prot:

TB10C_HUMAN :
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
Domain:
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D10C: view

No data available for Gene Families for TBC1D10C Gene

Function for TBC1D10C Gene

Molecular function for TBC1D10C Gene

UniProtKB/Swiss-Prot Function:
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.

Gene Ontology (GO) - Molecular Function for TBC1D10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D10C: view
genes like me logo Genes that share phenotypes with TBC1D10C: view

Animal Models for TBC1D10C Gene

MGI Knock Outs for TBC1D10C:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D10C Gene

Localization for TBC1D10C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D10C gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TBC1D10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 17562788
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TBC1D10C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D10C Gene

Pathways & Interactions for TBC1D10C Gene

genes like me logo Genes that share pathways with TBC1D10C: view

Pathways by source for TBC1D10C Gene

Gene Ontology (GO) - Biological Process for TBC1D10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0042147 retrograde transport, endosome to Golgi IMP 17562788
GO:0050869 negative regulation of B cell activation IEA --
GO:0051534 negative regulation of NFAT protein import into nucleus IEA --
genes like me logo Genes that share ontologies with TBC1D10C: view

No data available for SIGNOR curated interactions for TBC1D10C Gene

Transcripts for TBC1D10C Gene

Unigene Clusters for TBC1D10C Gene

TBC1 domain family, member 10C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for TBC1D10C Gene

GeneLoc Exon Structure for
TBC1D10C
ECgene alternative splicing isoforms for
TBC1D10C

Expression for TBC1D10C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBC1D10C Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D10C Gene

This gene is overexpressed in Whole Blood (x27.2) and Spleen (x8.0).

Protein differential expression in normal tissues from HIPED for TBC1D10C Gene

This gene is overexpressed in CD8 Tcells (16.1), Lymph node (9.6), Blymphocyte (9.0), NK cells (8.4), Peripheral blood mononuclear cells (8.3), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TBC1D10C Gene



Protein tissue co-expression partners for TBC1D10C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBC1D10C Gene:

TBC1D10C

SOURCE GeneReport for Unigene cluster for TBC1D10C Gene:

Hs.534648

mRNA Expression by UniProt/SwissProt for TBC1D10C Gene:

Q8IV04-TB10C_HUMAN
Tissue specificity: Most abundant in spleen and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TBC1D10C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TBC1D10C Gene

Orthologs for TBC1D10C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D10C 34 35
  • 96.19 (n)
dog
(Canis familiaris)
Mammalia TBC1D10C 34 35
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Tbc1d10c 34
  • 84.08 (n)
mouse
(Mus musculus)
Mammalia Tbc1d10c 34 16 35
  • 84.01 (n)
cow
(Bos Taurus)
Mammalia TBC1D10C 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D10C 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D10C 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101887140 34
  • 55.59 (n)
TBC1D10C 35
  • 14 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wkd 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-10 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSB4 35
  • 18 (a)
ManyToMany
MSB3 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6221 35
  • 40 (a)
OneToMany
Species where no ortholog for TBC1D10C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D10C Gene

ENSEMBL:
Gene Tree for TBC1D10C (if available)
TreeFam:
Gene Tree for TBC1D10C (if available)

Paralogs for TBC1D10C Gene

(5) SIMAP similar genes for TBC1D10C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TBC1D10C: view

Variants for TBC1D10C Gene

Sequence variations from dbSNP and Humsavar for TBC1D10C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10896172 -- 67,408,221(+) TGCTA(C/T)GCTCC intron-variant
rs111406922 -- 67,406,575(+) CTCCA(C/T)GGTCC intron-variant
rs112066087 -- 67,410,019(+) CCAAA(A/G)GAGTC nc-transcript-variant, utr-variant-3-prime
rs11227785 -- 67,407,410(+) GTGGC(A/G)ACAGT intron-variant
rs11227786 -- 67,408,897(+) GGGAG(A/G)CATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D10C Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv516453 CNV loss 19592680
nsv521723 CNV loss 19592680

Variation tolerance for TBC1D10C Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D10C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D10C Gene

Disorders for TBC1D10C Gene

Relevant External Links for TBC1D10C

Genetic Association Database (GAD)
TBC1D10C
Human Genome Epidemiology (HuGE) Navigator
TBC1D10C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D10C

No disorders were found for TBC1D10C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D10C Gene

Publications for TBC1D10C Gene

  1. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. (PMID: 17230191) Pan F. … Liu J.O. (Nature 2007) 2 3 4 64
  2. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. (PMID: 20404108) Hsu C. … Simons M. (J. Cell Biol. 2010) 2 3 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity. (PMID: 23109291) Schickel J.N. … Soulas-Sprauel P. (EMBO Mol Med 2012) 3 64

Products for TBC1D10C Gene

Sources for TBC1D10C Gene

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