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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBC1D10C Gene

protein-coding   GIFtS: 49
GCID: GC11P067171

TBC1 Domain Family, Member 10C

  Search for TBC1D10C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TBC1 Domain Family, Member 10C1 2
CARABIN2 5
EPI64C2
carabin2
TBC1 Domain Family Member 10C3

External Ids:    HGNC: 247021   Entrez Gene: 3744032   Ensembl: ENSG000001754637   OMIM: 6108315   UniProtKB: Q8IV043   

Export aliases for TBC1D10C gene to outside databases

Previous GC identifers: GC11P066929 GC11P063500


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBC1D10C Gene:
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for
calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by
calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2013)

GeneCards Summary for TBC1D10C Gene: 
TBC1D10C (TBC1 domain family, member 10C) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D3H.

UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04
Function: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity.
Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between
calcineurin and Ras




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBC1D10C gene promoter:
         HEN1   p53   Sp1   ARP-1   Lmo2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D10C promoter sequence
   Search SABiosciences Chromatin IP Primers for TBC1D10C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D10C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

TBC1D10C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D10C gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067171:  view genomic region     (about GC identifiers)

Start:
67,171,386 bp from pter      End:
67,177,560 bp from pter
Size:
6,175 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04 (See protein sequence)
Recommended Name: Carabin  
Size: 446 amino acids; 49712 Da
Subunit: Interacts with both calcineurin and HRAS
Secondary accessions: G3V1D6
Alternative splicing: 2 isoforms:  Q8IV04-1   Q8IV04-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D10C: NX_Q8IV04

Explore proteomics data for TBC1D10C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IV04

  • TBC1D10C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBC1D10C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243437.1  NP_940919.1  

    ENSEMBL proteins: 
     ENSP00000435543   ENSP00000435829   ENSP00000443654   ENSP00000310193  

    Human Recombinant Protein Products for TBC1D10C: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for TBC1D10C 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----

    TBC1D10C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q8IV04

    ProtoNet protein and cluster: Q8IV04

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04
    Similarity: Contains 1 Rab-GAP TBC domain


    TBC1D10C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TB10C_HUMAN, Q8IV04
    Function: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity.
    Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between
    calcineurin and Ras

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
         
    TBC1D10C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TBC1D10C:
     Increased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBC1D10C 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D10C 
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    SwitchGear 3'UTR luciferase reporter plasmidTBC1D10C 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D10C

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TBC1D10C (Q8IV043 ENSP000003101934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP3R2Q96LZ33, ENSP000003639394I2D: score=1 STRING: ENSP00000363939
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    TBC1D10C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBC1D10C (TB10C)

    Search CenterWatch for drugs/clinical trials and news about TBC1D10C / TB10C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBC1D10C gene (2 alternative transcripts): 
    NM_001256508.1  NM_198517.3  

    Unigene Cluster for TBC1D10C:

    TBC1 domain family, member 10C
    Hs.534648  [show with all ESTs]
    Unigene Representative Sequence: AK126131
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526387(uc001okz.3) ENST00000530967 ENST00000529635(uc001olb.3)
    ENST00000542590 ENST00000533745 ENST00000529132 ENST00000526474 ENST00000524662
    ENST00000312390(uc001ola.3)
    miRNA
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    hsa-miR-615-5p hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D10C 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK126131.1 BC022202.1 BC035630.1 BC036873.1 BC047319.1 BC062999.1 BC127792.1 NR_046266.1 

    8 DOTS entries:

    DT.100673427  DT.120703563  DT.100773238  DT.101976083  DT.101983129  DT.95274692  DT.100736554  DT.91685027 

    24/85 AceView cDNA sequences (see all 85):

    CR610401 BM564103 BM919968 BQ052902 BQ084220 BC047319 BC062999 BQ053995 
    BM916985 BX282482 AI471891 BM561466 BM918191 NM_198517 AK126131 BX360320 
    BI837186 BX443220 AK122585 BI906461 AI075269 BQ058264 BU615963 BM562380 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10C (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:                    -     -           -                 -           -           -                           
    SP2:        -           -     -           -                 -                                                   
    SP3:                    -     -           -                 -           -                                       
    SP4:                    -     -           -                 -           -                                       
    SP5:                    -     -           -                             -                                       


    ECgene alternative splicing isoforms for TBC1D10C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBC1D10C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACCGTCCT
    TBC1D10C Expression
    About this image


    See TBC1D10C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBC1D10C

    SOURCE GeneReport for Unigene cluster: Hs.534648

    UniProtKB/Swiss-Prot: TB10C_HUMAN, Q8IV04
    Tissue specificity: Most abundant in spleen and peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D10C gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d10c1 , 5 TBC1 domain family, member 10c1, 5 84.01(n)1
    88.51(a)1
      19 (3.88 cM)5
    1089951  NM_178650.31  NP_848765.21 
     41843585 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D10C6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    1(93168091-93180967)
    zebrafish
    (Danio rerio)
    Actinopterygii TBC1D10C6
    TBC1 domain family, member 10C
    13(a)
    1 ↔ 1
    14(22909158-22926271)
    fruit fly
    (Drosophila melanogaster)
    Insecta wkd6
    whacked
    39(a)
    1 → many
    3R(7407301-7411027)
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-106
    Protein TBC-10
    28(a)
    1 → many
    III(977386-988448)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDR16
    Cytoplasmic GTPase-activating protein for Ypt/Rab ...
    9(a)
    1 → many
    VII(690245-693097)


    ENSEMBL Gene Tree for TBC1D10C (if available)
    TreeFam Gene Tree for TBC1D10C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBC1D10C gene
    TBC1D3H2  TBC1D3F2  TBC1D32  TBC1D262  ENSG000002487512  TBC1D3C2  GRTP12  TBC1D10A2  
    TBC1D3G2  TBC1D10B2  USP6NL2  TBC1D282  TBC1D3B2  
    6 SIMAP similar genes for TBC1D10C using alignment to 3 protein entries:     TB10C_HUMAN (see all proteins):
    FLJ00332    FLJ00288    TBC1D10B    TBC1D10A    dJ130H16.2    EVI5

    TBC1D10C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/196 SNPs in TBC1D10C are shown (see all 196)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164637901,2
    C,F--67089051(+) GGCGTG/TACCAA 3 -- us2k11Minor allele frequency- T:0.08WA 118
    rs793408781,2
    C,F--67089087(+) CCAGCT/CCTGTT 3 -- us2k14Minor allele frequency- C:0.42WA CSA 123
    rs74803901,2
    C,F,A,H--67089147(+) AAGCCC/GAACAG 3 -- us2k115Minor allele frequency- G:0.45NS EA NA WA CSA 954
    rs1902439491,2
    --67089181(+) GGAAGA/GTGTTG 3 -- us2k10--------
    rs1824173621,2
    --67089331(+) GCGCCA/CAGGCG 3 -- us2k10--------
    rs735039651,2
    C,F--67089665(+) CAAGTG/AATCCA 3 -- us2k13Minor allele frequency- A:0.08WA 122
    rs1466207871,2
    C--67089808(+) GCTGGA/GCACAG 3 -- us2k10--------
    rs783761931,2
    C,F--67089836(+) CCCAGC/GACTTT 3 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1438649361,2
    --67090026(+) CCAGGC/TGACAG 3 -- us2k10--------
    rs1879611351,2
    C--67090027(+) CAGGCA/GACAGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBC1D10C (67171386 - 67177560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TBC1D10C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516453CNV Loss19592680
    nsv897796CNV Loss21882294
    dgv1195n71CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    nsv897811CNV Loss21882294
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897804CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TBC1D10C for disorders           About MalaCards
    OMIM gene information: 610831    OMIM disorders: --


    TBC1D10C for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBC1D10C
    Human Genome Epidemiology (HuGE) Navigator: TBC1D10C (3 documents)

    Export disorders for TBC1D10C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBC1D10C gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TBC1D10C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. (PubMed id 17230191)1, 2, 3 Pan F.... Liu J.O. (2007)
    2. Regulation of exosome secretion by Rab35 and its GTPa se-activating proteins TBC1D10A-C. (PubMed id 20404108)1, 3 Hsu C....Simons M. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Carabin deficiency in B cells increases BCR-TLR9 costi mulation-induced autoimmunity. (PubMed id 23109291)1 Schickel J.N....Soulas-Sprauel P. (2012)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. Calcineurin inhibitors activate the proto-oncogene Ra s and promote protumorigenic signals in renal cancer cells. (PubMed id 19903851)1 Datta D....Pal S. (2009)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374403 HGNC: 24702 AceView: FLJ00332 Ensembl:ENSG00000175463 euGenes: HUgn374403
    ECgene: TBC1D10C H-InvDB: TBC1D10C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBC1D10C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBC1D10C gene:
    Search GeneIP for patents involving TBC1D10C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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