Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TBC1D10B Gene

protein-coding   GIFtS: 47
GCID: GC16M030368

TBC1 Domain Family, Member 10B

  Search for TBC1D10B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TBC1 Domain Family, Member 10B1 2
EPI64B2
Rab27A-GAPbeta2
rab27A-GAP-beta2
TBC1 Domain Family Member 10B2
Rab27A-GAP-beta3

External Ids:    HGNC: 245101   Entrez Gene: 260002   Ensembl: ENSG000001692217   OMIM: 6136205   UniProtKB: Q4KMP73   

Export aliases for TBC1D10B gene to outside databases

Previous GC identifers: GC16M030277 GC16M030279 GC16M027930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TBC1D10B Gene:
Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching
from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs;
see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the
Rab family (Ishibashi et al., 2009 (PubMed 19077034)).(supplied by OMIM, Nov 2010)

GeneCards Summary for TBC1D10B Gene:
TBC1D10B (TBC1 domain family, member 10B) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D3H.

UniProtKB/Swiss-Prot: TB10B_HUMAN, Q4KMP7
Function: Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D10B gene promoter:
         Bach1   HOXA9   HOXA9B   Elk-1   p53   C/EBPalpha   Meis-1b   HFH-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D10B promoter sequence
   Search Chromatin IP Primers for TBC1D10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TBC1D10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D10B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030368:  view genomic region     (about GC identifiers)

Start:
30,368,422 bp from pter      End:
30,381,585 bp from pter
Size:
13,164 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TB10B_HUMAN, Q4KMP7 (See protein sequence)
Recommended Name: TBC1 domain family member 10B  
Size: 808 amino acids; 87199 Da
Sequence caution: Sequence=AAH50523.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH63112.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH72453.2;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH93814.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAH93816.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAH98419.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAQ15206.1; Type=Frameshift; Positions=154, 379, 401; Sequence=BAA92086.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14454.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAH16638.1; Type=Miscellaneous discrepancy;
Note=Probable cloning artifact; Sequence=EAW52256.1; Type=Erroneous gene model prediction;
Secondary accessions: B9A6L0 Q6IN54 Q6P530 Q71RG7 Q86VC5 Q9H8Z2 Q9NUN6 Q9UFP2
Alternative splicing: 2 isoforms:  Q4KMP7-1   Q4KMP7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D10B: NX_Q4KMP7

Explore proteomics data for TBC1D10B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys398, Lys405
  • Modification sites at PhosphoSitePlus

  • See TBC1D10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056342.3  
    ENSEMBL proteins: 
     ENSP00000386538   ENSP00000456663  

    TBC1D10B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TBC1D10B
    GenScript Custom Purified and Recombinant Proteins Services for TBC1D10B
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBC1D10B

    TBC1D10B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TBC1D10B
    Novus Biologicals TBC1D10B Antibody
    Abcam antibodies for TBC1D10B (Q4KMP7, Q9H8Z2)
    Cloud-Clone Corp. Antibodies for TBC1D10B
    Search ThermoFisher Antibodies for TBC1D10B
    LSBio Antibodies in human, mouse, rat for TBC1D10B

    TBC1D10B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TBC1D10B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TBC1D10B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBC1D10B
    Cloud-Clone Corp. CLIAs for TBC1D10B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q4KMP7

    ProtoNet protein and cluster: Q4KMP7

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TB10B_HUMAN, Q4KMP7
    Similarity: Contains 1 Rab-GAP TBC domain


    TBC1D10B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TB10B_HUMAN, Q4KMP7
    Function: Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IDA19077034
         
    TBC1D10B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TBC1D10B:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D10B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBC1D10B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D10B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D10B

    miRNA
    Products:
        
    miRTarBase miRNAs that target TBC1D10B:
    hsa-mir-149-5p (MIRT045563), hsa-mir-324-5p (MIRT043239), hsa-mir-151a-5p (MIRT038187)

    Block miRNA regulation of human, mouse, rat TBC1D10B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D10B (see all 19):
    hsa-miR-30c hsa-miR-4251 hsa-miR-657 hsa-miR-30d hsa-miR-23b* hsa-miR-30a hsa-miR-761 hsa-miR-518c
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D10B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TBC1D10B
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D10B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TBC1D10B

    Clone
    Products:
         
    OriGene clones in human, mouse for TBC1D10B (see all 7)
    OriGene ORF clones in mouse, rat for TBC1D10B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBC1D10B (NM_015527)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D10B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D10B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TBC1D10B
    Browse ESI BIO Cell Lines and PureStem Progenitors for TBC1D10B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TB10B_HUMAN, Q4KMP7: Cytoplasm. Note=In melanocytes, located at the periphery of cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    TBC1D10B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D10B
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D10B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TBC1D10B (ENSP000003865384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1ENSP000002664584STRING: ENSP00000266458
    MAP1LC3AENSP000003639704STRING: ENSP00000363970
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity IDA19077034
    GO:0032851positive regulation of Rab GTPase activity IDA19077034

    TBC1D10B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D10B (TB10B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TBC1D10B gene: 
    NM_015527.3  

    Unigene Cluster for TBC1D10B:

    TBC1 domain family, member 10B
    Hs.632182  [show with all ESTs]
    Unigene Representative Sequence: BC028737
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475650(uc002dxt.2) ENST00000409939(uc002dxu.2) ENST00000478158
    ENST00000490703 ENST00000475872 ENST00000566671 ENST00000464644
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBC1D10B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D10B (see all 19):
    hsa-miR-30c hsa-miR-4251 hsa-miR-657 hsa-miR-30d hsa-miR-23b* hsa-miR-30a hsa-miR-761 hsa-miR-518c
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D10B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TBC1D10B
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D10B
    Clone
    Products:
         
    OriGene clones in human, mouse for TBC1D10B (see all 7)
    OriGene ORF clones in mouse, rat for TBC1D10B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBC1D10B (NM_015527)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D10B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D10B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TBC1D10B
    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D10B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D10B
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D10B
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D10B

    Additional mRNA sequence: 

    AB449895.1 AF370370.1 AK002101.1 AK023192.1 AY007150.1 BC028737.1 BC038994.1 BC050523.2 
    BC063112.1 BC072453.1 BC093814.1 BC093816.1 BC098419.1 

    10 DOTS entries:

    DT.100059322  DT.413663  DT.91818284  DT.100696112  DT.120671362  DT.40212595  DT.75155095  DT.92430790 
    DT.100715628  DT.100749654 

    Selected AceView cDNA sequences (see all 181):

    BQ954889 AU131646 BU171493 BM561704 AL042941 BM817569 BX092339 AY007150 
    BQ653749 BQ688294 BQ054293 AW137171 BU507849 CF264977 BC028737 BQ063911 
    BU739896 BU190723 NM_015527 BQ438958 AI634733 BC072453 BM797414 CR594390 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10B (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
    SP1:        -                       -     -           -                                             
    SP2:                                -     -           -                                             
    SP3:                                -     -           -           -     -     -                     
    SP4:                                                  -           -     -     -                     
    SP5:                                                  -                                             


    ECgene alternative splicing isoforms for TBC1D10B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TBC1D10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGCTTTG
    TBC1D10B Expression
    About this image

    TBC1D10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D10B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632182
        Custom PCR Arrays for TBC1D10B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TBC1D10B
    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D10B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D10B
    QuantiTect SYBR Green Assays in human, mouse, rat TBC1D10B
    QuantiFast Probe-based Assays in human, mouse, rat TBC1D10B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D10B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d10b1 , 5 TBC1 domain family, member 10b1, 5 86.88(n)1
    89.49(a)1
      7 (69.38 cM)5
    684491  NM_144522.51  NP_653105.31 
     1271974655 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D10B6
    TBC1 domain family, member 10B
    75(a)
    1 ↔ 1
    GL343516.1(322262-338984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.298092 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_114143.1 (H.sapiens) EBP50-PDZ interactor of 64 kD [Homo sapiens] less 81.41(n)    BJ029447.1 
    zebrafish
    (Danio rerio)
    Actinopterygii TBC1D10B6
    TBC1 domain family, member 10B
    49(a)
    1 ↔ 1
    3(32931781-32948336) ENSDARG00000078604
    fruit fly
    (Drosophila melanogaster)
    Insecta wkd6
    whacked
    40(a)
    1 → many
    3R(7407301-7411027)
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-106
    Protein TBC-10 (tbc-10) mRNA, complete cds
    38(a)
    1 → many
    III(977386-988448) WBGene00019915
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSB46
    MSB36
    GTPase-activating protein of the Ras superfamily t...
    GTPase-activating protein for Sec4p and several ot...
    20(a)
    17(a)
    many ↔ many
    many ↔ many
    XV(106710-108188) YOL112W
    XIV(80640-82541) YNL293W


    ENSEMBL Gene Tree for TBC1D10B (if available)
    TreeFam Gene Tree for TBC1D10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TBC1D10B gene
    TBC1D3H2  TBC1D3F2  TBC1D32  TBC1D262  ENSG000002487512  TBC1D3C2  GRTP12  TBC1D10C2  
    TBC1D10A2  TBC1D3G2  USP6NL2  TBC1D282  TBC1D3B2  
    5 SIMAP similar genes for TBC1D10B using alignment to 2 protein entries:     TB10B_HUMAN (see all proteins):
    FLJ00288    TBC1D10A    TBC1D10C    TBC1D3G    SGSM3

    TBC1D10B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TBC1D10B (see all 273)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856583771,2
    --30368762(+) CAGAAA/GACAAA 1 -- ut310--------
    rs1904256271,2
    --30368889(+) GGAAGC/GCAGCT 1 -- ut310--------
    rs1380399871,2
    --30368924(+) GAGTG-/TTAAGA 1 -- ut310--------
    rs1829517761,2
    C--30368924(+) GGAGTC/GTAAGA 1 -- ut310--------
    rs740150061,2
    C,F--30369030(+) GGCAGG/AAGCGA 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1871075731,2
    --30369110(+) GCCCGC/TGTAGG 1 -- ut310--------
    rs1916427811,2
    --30369129(+) GCTGGA/CGAGGA 1 -- ut310--------
    rs1420255311,2
    --30369138(+) GAGATA/GGGGAA 1 -- ut310--------
    rs1839392241,2
    --30369244(+) CATGCA/CGTCCA 1 -- ut310--------
    rs1451700741,2
    C,F--30369277(+) TAAGCG/ATCCTG 2 /D syn11Minor allele frequency- A:0.00NA 2544

    HapMap Linkage Disequilibrium report for TBC1D10B (30368422 - 30381585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TBC1D10B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26390CNV Loss19812545
    nsv905724CNV Loss21882294
    nsv905725CNV Loss21882294
    nsv827612CNV Gain20364138
    dgv847e1CNV Complex17122850
    dgv846e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D10B
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613620    OMIM disorders: --


    TBC1D10B for disorders           About GeneDecksing


    Export disorders for TBC1D10B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TBC1D10B gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TBC1D10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. (PubMed id 20404108)1, 3 Hsu C....Simons M. (J. Cell Biol. 2010)
    2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras. (PubMed id 23248241)1 Nagai H....Nakamura T. (J. Biochem. 2013)
    7. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (Mol. Cell. Biol. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26000 HGNC: 24510 AceView: DKFZP434P1750 Ensembl:ENSG00000169221 euGenes: HUgn26000
    ECgene: TBC1D10B H-InvDB: TBC1D10B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TBC1D10B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TBC1D10B gene:
    Search GeneIP for patents involving TBC1D10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TBC1D10B  
     OriGene qPCR primer pairs and template standards for TBC1D10B   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TBC1D10B  
     OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D10B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TBC1D10B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TBC1D10B   OriGene Custom Protein Services for TBC1D10B  

     
     
     Block miRNA regulation of human, mouse, rat TBC1D10B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TBC1D10B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D10B Predesigned siRNA for gene silencing in human, mouse, rat TBC1D10B
     QuantiFast Probe-based Assays in human, mouse, rat TBC1D10B QuantiTect SYBR Green Assays in human, mouse, rat TBC1D10B
     Custom PCR Arrays for TBC1D10B Search Chromatin IP Primers for TBC1D10B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D10B  Search GeneGlobe Interaction Network for TBC1D10B
     Regulatory tfbs in TBC1D10B promoter
     GenScript Custom Purified and Recombinant Proteins Services for TBC1D10B GenScript cDNA clones with any tag delivered in your preferred vector for TBC1D10B
     GenScript Custom Assay Services for TBC1D10B GenScript Custom overexpressing Cell Line Services for TBC1D10B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TBC1D10B (TB10B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TBC1D10B antibodies
     Antibodies for TBC1D10B
     See all of Abcam's Antibodies, Kits and Proteins for TBC1D10B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TBC1D10B
     Antibodies for TBC1D10B
     ELISAs for TBC1D10B
     CLIAs for TBC1D10B



     Browse ESI BIO Cell Lines and PureStem Progenitors for TBC1D10B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10B
     SwitchGear 3'UTR luciferase reporter plasmids for TBC1D10B
     SwitchGear Promoter luciferase reporter plasmids for TBC1D10B
     Search ThermoFisher Antibodies for TBC1D10B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D10B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D10B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBC1D10B
     LSBio Antibodies in human, mouse, rat for TBC1D10B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TBC1D10B gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4