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Aliases for TBC1D10B Gene

Aliases for TBC1D10B Gene

  • TBC1 Domain Family Member 10B 2 3 5
  • Rab27A-GAP-Beta 3 4
  • TBC1 Domain Family, Member 10B 2
  • Rab27A-GAPbeta 3
  • EPI64B 3
  • FP2461 3

External Ids for TBC1D10B Gene

Previous GeneCards Identifiers for TBC1D10B Gene

  • GC16M030277
  • GC16M030279
  • GC16M027930

Summaries for TBC1D10B Gene

Entrez Gene Summary for TBC1D10B Gene

  • Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TBC1D10B Gene

TBC1D10B (TBC1 Domain Family Member 10B) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and TBC/RABGAPs. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D10A.

UniProtKB/Swiss-Prot for TBC1D10B Gene

  • Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.

Additional gene information for TBC1D10B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D10B Gene

Genomics for TBC1D10B Gene

Regulatory Elements for TBC1D10B Gene

Enhancers for TBC1D10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030416 1.5 FANTOM5 Ensembl ENCODE 11.4 -47.5 -47546 2 ARNT SIN3A GLIS2 ELK1 ZNF143 ZNF207 KLF7 RUNX3 ZNF488 ZNF592 ENSG00000260304 CD2BP2 SEPT1 TBC1D10B MYLPF SETD1A ZNF688 ENSG00000239791 ZNF785 ZNF689
GH16H030398 1.4 Ensembl ENCODE 11.9 -30.1 -30132 3 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 SMG1P5 FUS ZNF785 ENSG00000260114 ZNF747 SETD1A TBC1D10B SPN PYCARD CD2BP2
GH16H030547 1.5 Ensembl ENCODE dbSUPER 10.6 -178.7 -178709 2 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS ATF7 NCOA1 ZNF689 ZNF764 SETD1A ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2
GH16H030074 1.3 ENCODE dbSUPER 11 +293.6 293580 4 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZHX2 REST ZNF592 KAT8 YPEL3 SRCAP SETD1A GDPD3 ZNF764 SMG1P5 ENSG00000198106 INO80E SMG1P2 NPIPB12
GH16H030393 1.1 ENCODE 12 -24.9 -24863 2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 SETD1A FUS INO80E SRCAP ZNF764 ZNF689 SMG1P5 BCL7C FBRS ZNF785
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TBC1D10B on UCSC Golden Path with GeneCards custom track

Promoters for TBC1D10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085187 564 3401 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for TBC1D10B Gene

Chromosome:
16
Start:
30,357,101 bp from pter
End:
30,370,264 bp from pter
Size:
13,164 bases
Orientation:
Minus strand

Genomic View for TBC1D10B Gene

Genes around TBC1D10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D10B Gene

Proteins for TBC1D10B Gene

  • Protein details for TBC1D10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMP7-TB10B_HUMAN
    Recommended name:
    TBC1 domain family member 10B
    Protein Accession:
    Q4KMP7
    Secondary Accessions:
    • B9A6L0
    • Q6IN54
    • Q6P530
    • Q71RG7
    • Q86VC5
    • Q9H8Z2
    • Q9NUN6
    • Q9UFP2

    Protein attributes for TBC1D10B Gene

    Size:
    808 amino acids
    Molecular mass:
    87199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH50523.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH63112.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH72453.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH93814.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH93816.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15206.1; Type=Frameshift; Positions=154, 379, 401; Evidence={ECO:0000305}; Sequence=BAA92086.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14454.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH16638.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=EAW52256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D10B Gene

Post-translational modifications for TBC1D10B Gene

  • Ubiquitination at Lys398 and posLast=405405
  • Modification sites at PhosphoSitePlus

Other Protein References for TBC1D10B Gene

No data available for DME Specific Peptides for TBC1D10B Gene

Domains & Families for TBC1D10B Gene

Gene Families for TBC1D10B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBC1D10B Gene

Suggested Antigen Peptide Sequences for TBC1D10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBC1D10B: view

No data available for UniProtKB/Swiss-Prot for TBC1D10B Gene

Function for TBC1D10B Gene

Molecular function for TBC1D10B Gene

UniProtKB/Swiss-Prot Function:
Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.

Gene Ontology (GO) - Molecular Function for TBC1D10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 19077034
GO:0005515 protein binding IPI 22354992
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D10B: view
genes like me logo Genes that share phenotypes with TBC1D10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TBC1D10B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D10B Gene

Localization for TBC1D10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D10B Gene

Cytoplasm. Note=In melanocytes, located at the periphery of cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D10B gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TBC1D10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 17562788
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with TBC1D10B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TBC1D10B Gene

Pathways & Interactions for TBC1D10B Gene

genes like me logo Genes that share pathways with TBC1D10B: view

Pathways by source for TBC1D10B Gene

3 Reactome pathways for TBC1D10B Gene

Gene Ontology (GO) - Biological Process for TBC1D10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0042147 retrograde transport, endosome to Golgi IMP 17562788
GO:0043087 regulation of GTPase activity IDA 19077034
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D10B: view

No data available for SIGNOR curated interactions for TBC1D10B Gene

Drugs & Compounds for TBC1D10B Gene

No Compound Related Data Available

Transcripts for TBC1D10B Gene

Unigene Clusters for TBC1D10B Gene

TBC1 domain family, member 10B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TBC1D10B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for TBC1D10B Gene

GeneLoc Exon Structure for
TBC1D10B
ECgene alternative splicing isoforms for
TBC1D10B

Expression for TBC1D10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D10B Gene

Protein differential expression in normal tissues from HIPED for TBC1D10B Gene

This gene is overexpressed in Monocytes (11.5), Frontal cortex (11.2), Peripheral blood mononuclear cells (10.5), and Amniocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TBC1D10B Gene



Protein tissue co-expression partners for TBC1D10B Gene

NURSA nuclear receptor signaling pathways regulating expression of TBC1D10B Gene:

TBC1D10B

SOURCE GeneReport for Unigene cluster for TBC1D10B Gene:

Hs.632182

Evidence on tissue expression from TISSUES for TBC1D10B Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TBC1D10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D10B Gene

Orthologs for TBC1D10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D10B 33 34
  • 99.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D10B 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D10B 33 34
  • 89.42 (n)
dog
(Canis familiaris)
Mammalia TBC1D10B 34
  • 89 (a)
OneToOne
LOC489935 33
  • 87.82 (n)
rat
(Rattus norvegicus)
Mammalia Tbc1d10b 33
  • 87.54 (n)
mouse
(Mus musculus)
Mammalia Tbc1d10b 33 16 34
  • 86.88 (n)
oppossum
(Monodelphis domestica)
Mammalia TBC1D10B 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D10B 34
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29809 33
zebrafish
(Danio rerio)
Actinopterygii TBC1D10B 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wkd 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-10 34
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSB4 34
  • 20 (a)
ManyToMany
MSB3 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6221 34
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.929 33
Species where no ortholog for TBC1D10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D10B Gene

ENSEMBL:
Gene Tree for TBC1D10B (if available)
TreeFam:
Gene Tree for TBC1D10B (if available)

Paralogs for TBC1D10B Gene

(5) SIMAP similar genes for TBC1D10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TBC1D10B: view

Variants for TBC1D10B Gene

Sequence variations from dbSNP and Humsavar for TBC1D10B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000062567 -- 30,364,676(+) GCAAG(C/T)TCTTC intron-variant
rs1000240179 -- 30,370,833(+) CGAGT(-/AA)GAGGT intron-variant, upstream-variant-2KB
rs1000653113 -- 30,369,674(+) GCAAG(A/C/G)GGGGG upstream-variant-2KB, reference, synonymous-codon
rs1000808286 -- 30,362,849(+) CTGGC(C/T)AACAT intron-variant
rs1000947587 -- 30,366,666(+) TAAAG(G/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D10B Gene

Variant ID Type Subtype PubMed ID
esv26390 CNV loss 19812545
esv2758642 CNV gain 17122850
nsv827612 CNV gain 20364138

Variation tolerance for TBC1D10B Gene

Gene Damage Index Score: 8.24; 85.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D10B Gene

Human Gene Mutation Database (HGMD)
TBC1D10B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D10B Gene

Disorders for TBC1D10B Gene

Relevant External Links for TBC1D10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D10B

No disorders were found for TBC1D10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D10B Gene

Publications for TBC1D10B Gene

  1. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. (PMID: 20404108) Hsu C … Simons M (The Journal of cell biology 2010) 2 3 60
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 60

Products for TBC1D10B Gene

Sources for TBC1D10B Gene

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