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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBC1D10A Gene

protein-coding   GIFtS: 51
GCID: GC22M030687

TBC1 Domain Family, Member 10A

(Previous names: TBC1 domain family, member 10)
(Previous symbol: TBC1D10)
  Search for TBC1D10A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TBC1 Domain Family, Member 10A1 2     dJ130H16.12
TBC1D101 2 3     dJ130H16.22
EPI642 3 5     rab27A-GAP-alpha2
EBP50-PDZ Interactor Of 64 KD1 2     TBC1 Domain Family Member 10A2
EBP50-PDX Interactor Of 64 KDa2 3     Rab27A-GAP-alpha3
TBC1 Domain Family, Member 101     EPI64 Protein3

External Ids:    HGNC: 236091   Entrez Gene: 838742   Ensembl: ENSG000000999927   OMIM: 6100205   UniProtKB: Q9BXI63   

Export aliases for TBC1D10A gene to outside databases

Previous GC identifers: GC22M029016 GC22M029017 GC22M030683 GC22M013649


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TBC1D10A Gene: 
TBC1D10A (TBC1 domain family, member 10A) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is TBC1D3H.

UniProtKB/Swiss-Prot: TB10A_HUMAN, Q9BXI6
Function: Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A

Gene Wiki entry for TBC1D10A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBC1D10A gene promoter:
         E2F-4   E2F-3a   NF-1   E2F-5   E2F-2   LCR-F1   GATA-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D10A promoter sequence
   Search SABiosciences Chromatin IP Primers for TBC1D10A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

TBC1D10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D10A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030687:  view genomic region     (about GC identifiers)

Start:
30,687,979 bp from pter      End:
30,723,035 bp from pter
Size:
35,057 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TB10A_HUMAN, Q9BXI6 (See protein sequence)
Recommended Name: TBC1 domain family member 10A  
Size: 508 amino acids; 57118 Da
Subunit: Binds to the first PDZ domain of SLC9A3R1 and SLC9A3R2
Subcellular location: Cell projection, microvillus. Note=Localizes to the microvilli-rich region of the
syncytiotrophoblast. In melanocytes, located at the periphery of cells
Sequence caution: Sequence=AAC23434.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KXT8 O76053 Q543A2
Alternative splicing: 2 isoforms:  Q9BXI6-1   Q9BXI6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D10A: NX_Q9BXI6

Explore proteomics data for TBC1D10A at MOPED 

Post-translational modifications:

  • UniProtKB: Exists in both phosphorylated and non-phosphorylated state
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXI6

  • TBC1D10A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBC1D10A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191169.1  NP_114143.1  

    ENSEMBL proteins: 
     ENSP00000215790   ENSP00000384996   ENSP00000385050   ENSP00000400620   ENSP00000389994  
     ENSP00000377484  

    Human Recombinant Protein Products for TBC1D10A: 
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    Cloud-Clone Corp. Proteins for TBC1D10A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005902microvillus TAS11285285

    TBC1D10A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q9BXI6

    ProtoNet protein and cluster: Q9BXI6

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TB10A_HUMAN, Q9BXI6
    Similarity: Contains 1 Rab-GAP TBC domain


    TBC1D10A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TB10A_HUMAN, Q9BXI6
    Function: Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI11285285
    GO:0030165PDZ domain binding IPI11285285
         
    TBC1D10A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TBC1D10A:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tbc1d10a):
     cellular  homeostasis/metabolism 

    TBC1D10A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBC1D10A 
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    SwitchGear 3'UTR luciferase reporter plasmidTBC1D10A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TBC1D10A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for TBC1D10A
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D10A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/32 Interacting proteins for TBC1D10A (Q9BXI62, 3 ENSP000002157904) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, 3, ENSP000002626134MINT-73249 MINT-73244 MINT-73247 I2D: score=3 STRING: ENSP00000262613
    EZRP153112, 3, ENSP000003389344MINT-73250 I2D: score=2 STRING: ENSP00000338934
    SLC9A3R2Q155992, 3, ENSP000004080054MINT-73248 I2D: score=2 STRING: ENSP00000408005
    HSPA8P111423I2D: score=4 
    DIAPH1O606103I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0032313regulation of Rab GTPase activity ----
    GO:0045862positive regulation of proteolysis IDA18387192
    GO:0097202activation of cysteine-type endopeptidase activity IDA18387192

    TBC1D10A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBC1D10A (TB10A)

    Search CenterWatch for drugs/clinical trials and news about TBC1D10A / TB10A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBC1D10A gene (2 alternative transcripts): 
    NM_001204240.1  NM_031937.2  

    Unigene Cluster for TBC1D10A:

    TBC1 domain family, member 10A
    Hs.655273  [show with all ESTs]
    Unigene Representative Sequence: AK131086
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215790(uc010gvu.3 uc003ahk.4) ENST00000467596 ENST00000462073
    ENST00000403477 ENST00000403362 ENST00000433426 ENST00000466666 ENST00000437122
    ENST00000393906 ENST00000490449
    miRNA
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    hsa-miR-3173-3p hsa-miR-466 hsa-miR-3065-3p hsa-miR-548aa hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D10A 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB449894.1 AF331038.1 AK074656.1 AK127939.1 AK130333.1 AK131086.1 AK309455.1 BC007908.2 
    BC022201.1 BC136815.1 BC142940.1 BC150187.1 BC150214.1 BC171775.1 CT841514.1 

    22 DOTS entries:

    DT.75102442  DT.212857  DT.100848454  DT.101984806  DT.95314930  DT.100848443  DT.91708500  DT.92059484 
    DT.100720909  DT.100848460  DT.120657255  DT.120657294  DT.91831429  DT.100766513  DT.100772112  DT.100848456 
    DT.120657241  DT.120657251  DT.120657291  DT.100848459  DT.91991967  DT.97843495 

    24/360 AceView cDNA sequences (see all 360):

    H55174 CR611776 BE349507 BX361800 CR626545 AI244512 CR610602 T81218 
    AK093231 AU279576 CR594046 BI755380 BM704530 BX358435 BX432662 F33218 
    AK074656 BG938738 CD519225 BU553355 AW002906 CR621862 BX394992 CR603728 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D10A (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                    -     -     -           -           -           -                                         -     -               
    SP2:                    -     -                 -           -           -                                         -     -               
    SP3:                          -     -           -           -           -                                                               
    SP4:                                -           -           -           -                                                               
    SP5:                                                                                                              -     -               


    ECgene alternative splicing isoforms for TBC1D10A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBC1D10A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTGTACA
    TBC1D10A Expression
    About this image


    See TBC1D10A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBC1D10A

    SOURCE GeneReport for Unigene cluster: Hs.655273
        SABiosciences Custom PCR Arrays for TBC1D10A
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D10A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D10A gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d10a1 , 5 TBC1 domain family, member 10a1, 5 88.07(n)1
    92(a)1
      11 (2.92 cM)5
    1037241  NM_134023.11  NP_598784.11 
     41867895 
    chicken
    (Gallus gallus)
    Aves TBC1D10A1 TBC1 domain family, member 10A 78.04(n)
    81.73(a)
      417011  XM_415301.3  XP_415301.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    75(a)
    1 → many
    GL343338.1(232812-254615)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102972 Xenopus laevis transcribed sequence with moderate similarity more 79.94(n)    BX844611.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbc1d10a1 TBC1 domain family, member 10A 66.95(n)
    69.33(a)
      562628  XM_686009.1  XP_691101.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wkd1 whacked 54.67(n)
    45.43(a)
      41390  NM_169402.3  NP_731593.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-101 Protein TBC-10 53.79(n)
    52.6(a)
      3564790  NM_064909.3  NP_497310.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDR16
    Cytoplasmic GTPase-activating protein for Ypt/Rab ...
    9(a)
    1 → many
    VII(690245-693097)


    ENSEMBL Gene Tree for TBC1D10A (if available)
    TreeFam Gene Tree for TBC1D10A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBC1D10A gene
    TBC1D3H2  TBC1D3F2  TBC1D32  TBC1D262  ENSG000002487512  TBC1D3C2  GRTP12  TBC1D10C2  
    TBC1D3G2  TBC1D10B2  USP6NL2  TBC1D282  TBC1D3B2  
    14 SIMAP similar genes for TBC1D10A using alignment to 7 protein entries:     TB10A_HUMAN (see all proteins):
    FLJ00288    dJ130H16.2    TBC1D10B    TBC1D10C    TBC1D3    TBC1D3F
    TBC1D3G    TBC1D3H    EVI5    TBC1D8    TBC1D8B    SGSM3
    GRTP1    TBC1D6

    TBC1D10A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/701 SNPs in TBC1D10A are shown (see all 701)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453105101,2
    Cuntested130688494(+) GCTGTA/C/GGGGGA 4 P L mis11NA 4534
    rs1465269071,2
    --30687641(+) GAAACA/CTCCTC 2 -- int10--------
    rs1141346501,2
    F--30687734(+) AGCCCT/CGGTGT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1391757061,2
    --30687975(+) TACACA/GAGCTC 2 -- int10--------
    rs738814311,2
    C,F--30688107(+) TGAAGG/AAGGCC 2 -- ut313Minor allele frequency- A:0.20WA CSA 122
    rs96088671,2
    A--30688217(+) ACCAGC/GCAGAA 2 -- ut31 ese30--------
    rs778429571,2
    C--30688339(+) ACCCCG/ACCCTG 2 -- ut312Minor allele frequency- A:0.01WA EU 1441
    rs2017383031,2
    --30688366(+) GGGTTA/GCAAGT 4 Q * stop-lost0--------
    rs1877175331,2
    C--30688414(+) GGAGCA/GGTGGT 4 R C mis10--------
    rs2009297351,2
    --30688444(+) CAAATA/CCTGAG 4 D Y mis10--------

    HapMap Linkage Disequilibrium report for TBC1D10A (30687979 - 30723035 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TBC1D10A:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4954n71CNV Loss21882294
    nsv3593CNV Loss18451855
    nsv522605CNV Loss19592680
    nsv829171CNV Loss20364138
    dgv4955n71CNV Loss21882294
    nsv914970CNV Loss21882294
    nsv834174CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TBC1D10A for disorders           About MalaCards
    OMIM gene information: 610020    OMIM disorders: --


    TBC1D10A for disorders           About GeneDecksing


    Export disorders for TBC1D10A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBC1D10A gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with TBC1D10A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. (PubMed id 11285285)1, 2, 3 Reczek D. and Bretscher A. (2001)
    2. Regulation of exosome secretion by Rab35 and its GTPa se-activating proteins TBC1D10A-C. (PubMed id 20404108)1, 3 Hsu C....Simons M. (2010)
    3. Identification of EPI64 as a GTPase-activating protein specific for Rab27A. (PubMed id 16923811)1, 2 Itoh T. and Fukuda M. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    6. All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras. (PubMed id 23248241)1 Nagai H....Nakamura T. (2013)
    7. Rab GTPase-activating proteins in autophagy: regulatio n of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. (PubMed id 22219378)1 Hokanson D.E. and Bretscher A.P. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83874 HGNC: 23609 AceView: TBC1D10 Ensembl:ENSG00000099992 euGenes: HUgn83874
    ECgene: TBC1D10A H-InvDB: TBC1D10A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBC1D10A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBC1D10A gene:
    Search GeneIP for patents involving TBC1D10A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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