TBATA Gene
protein-coding GIFtS: 35
GCID: GC10M072531
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|
thymus, brain and testes associated(Previous name: chromosome 10 open reading frame 27 )
(Previous symbol: C10orf27)
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Aliases
for TBATA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thymus, Brain And Testes Associated1 2 | | Thymus, Brain And Testes-Associated Protein2 3 | | C10orf271 2 3 5 | | FLJ328201 | | Spatial1 | | Chromosome 10 Open Reading Frame 271 | | Protein SPATIAL2 3 | | Protein TBATA2 | | Stromal Protein Associated With Thymii And Lymph Node Homolog2 3 | | SPATIAL3 |
Export aliases for TBATA gene to outside databases |
Summaries
for TBATA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBATA_HUMAN, Q96M53Function: May play a role in spermatid differentiation (By similarity). Modulates thymic stromal cell proliferation andthymus function (By similarity)
|
Genomic Views
for TBATA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TBATA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBATA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBATA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2TBATA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M072531: view genomic region
(about GC identifiers)
Start:
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72,530,995 bp from pter |
End:
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72,545,157 bp from pter |
Size:
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14,163 bases |
Orientation:
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minus strand |
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Proteins
for TBATA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBATA_HUMAN, Q96M53 (See
protein sequence)Recommended Name: Protein TBATA Size: 351 amino acids; 39460 Da
Subcellular location: Cytoplasm, cytosol (By similarity)
Secondary accessions: A4QPA8 B2RPQ2 Q5T4G2Alternative splicing: 2 isoforms: Q96M53-1 Q96M53-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TBATA: NX_Q96M53
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M53
TBATA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689923.2
ENSEMBL proteins: ENSP00000299290 ENSP00000378433 ENSP00000400224 ENSP00000444940
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
ISS | -- |
TBATA for ontologies About GeneDecksing
TBATA Antibody Products:
Assay Products for TBATA: |
Protein
Domains /
Families
for TBATA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96M53 UniProtKB/Swiss-Prot: TBATA_HUMAN, Q96M53Similarity: Belongs to the TBATA family |
Function
for TBATA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBATA_HUMAN, Q96M53Function: May play a role in spermatid differentiation (By similarity). Modulates thymic stromal cell proliferation andthymus function (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBATA (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBATA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TBATA | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBATA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBATA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBATA |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
TBATA for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tbatatm1Faf for TBATA
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tbata):
TBATA for phenotypes About GeneDecksing
|
Pathways & Interactions
for TBATA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBATA
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
TBATA for ontologies About GeneDecksing
|
Drugs & Compounds
for TBATA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBATA
Search CenterWatch for drugs/clinical trials and news about TBATA
|
Transcripts
for TBATA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBATA gene: NM_152710.2 Unigene Cluster for TBATA: Thymus, brain and testes associated Hs.386698 [show with all ESTs]Unigene Representative Sequence: AK1241474 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000299290(uc001jrj.1 uc010qjm.1 uc009xqh.1 uc010qjn.1 uc009xqi.1)
ENST00000394982 ENST00000456372(uc010qjo.1 uc010qjp.1) ENST00000545575(uc009xqj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBATA (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBATA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TBATA | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBATA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBATA |
Additional cDNA sequence: AK057382.1 AK124147.1 AK303242.1 AK303344.1 AK303491.1 AK310699.1 AK310732.1 BC127867.1 BC137543.1 BC137544.1 BC144692.1 BC144694.1 BC144695.1 8 DOTS entries: DT.99940926 DT.101966983 DT.121231769 DT.121231768 DT.121231772 DT.121231770 DT.75115486 DT.92046204 18 AceView cDNA sequences: AI352340 BP368090 AI017747 BP366731 BP368024 AK124147 BP366738 BP366417 BC060774 NM_152710 AK057382 BX106847 AI216494 BP368189 BP366436 AW172453 BI561350 AW269004
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TBATA (see all 14) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ |
|---|
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| SP1: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | |
| ExUns: | 11 | ^ | 12a | · | 12b |
|---|
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| SP1: | | | - | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for TBATA
|
Expression
for TBATA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TBATA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBATA
SOURCE GeneReport for Unigene cluster: Hs.386698
SABiosciences Custom PCR Arrays for TBATA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBATA
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TBATA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBATA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBATA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBATA |
Orthologs
for TBATA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TBATA gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for TBATA (if available)
TreeFam Gene Tree for TBATA (if available) |
Paralogs
for TBATA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TBATA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBATA (72530995 - 72545157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TBATA: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBATA |
|
Disorders
/ Diseases
for TBATA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBATA for disorders About GeneDecksing
OMIM gene information: 612640
OMIM disorders: --
2  diseases for TBATA: About MalaCardsmultiple sclerosis alzheimer's disease
Export disorders for TBATA gene to outside databases
|
Publications
for TBATA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBATA gene integrated from 9 sources:
(articles sorted by number of sources associating them with TBATA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tbata modulates thymic stromal cell proliferation and thymus function. (PubMed id 20937703)1, 3 Flomerfelt F.A....Gress R.E. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Spatial (Tbata) expression in mature medullary thymic epithelial cells. (PubMed id 19918778)1 Saade M....Nguyen C. (2010)
- Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis. (PubMed id 18208870)1 Goertsches R....Comabella M. (2008)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TBATA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBATA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBATA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBATA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBATA | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBATA gene:
Search GeneIP for patents involving TBATA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBATA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TBATA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBATA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBATA | | | OriGene Protein Over-expression Lysate for TBATA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBATA | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBATA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBATA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBATA | | OriGene Custom Protein Services for TBATA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBATA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBATA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBATA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBATA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBATA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBATA |
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 |  |  |  | |
| | | | Search Tocris compounds for TBATA |
| |  |  |  |  | | | | |
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 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBATA |
|  |  |  | | | | Search ThermoFisher Antibodies for TBATA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBATA |
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