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Aliases for TBATA Gene

Aliases for TBATA Gene

  • Thymus, Brain And Testes Associated 2 3 5
  • Stromal Protein Associated With Thymii And Lymph Node Homolog 3 4
  • Thymus, Brain And Testes-Associated Protein 3 4
  • C10orf27 3 4
  • SPATIAL 3 4
  • Chromosome 10 Open Reading Frame 27 2
  • Protein SPATIAL 4

External Ids for TBATA Gene

Previous HGNC Symbols for TBATA Gene

  • C10orf27

Previous GeneCards Identifiers for TBATA Gene

  • GC10M072531

Summaries for TBATA Gene

Entrez Gene Summary for TBATA Gene

  • This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TBATA Gene

TBATA (Thymus, Brain And Testes Associated) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TBATA Gene

  • May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBATA Gene

Genomics for TBATA Gene

Regulatory Elements for TBATA Gene

Enhancers for TBATA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBATA on UCSC Golden Path with GeneCards custom track

Genomic Location for TBATA Gene

Chromosome:
10
Start:
70,771,238 bp from pter
End:
70,785,401 bp from pter
Size:
14,164 bases
Orientation:
Minus strand

Genomic View for TBATA Gene

Genes around TBATA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBATA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBATA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBATA Gene

Proteins for TBATA Gene

  • Protein details for TBATA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M53-TBATA_HUMAN
    Recommended name:
    Protein TBATA
    Protein Accession:
    Q96M53
    Secondary Accessions:
    • A4QPA8
    • B2RPQ2
    • Q5T4G2

    Protein attributes for TBATA Gene

    Size:
    351 amino acids
    Molecular mass:
    39460 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBATA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBATA Gene

Proteomics data for TBATA Gene at MOPED

Post-translational modifications for TBATA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBATA Gene

No data available for DME Specific Peptides for TBATA Gene

Domains & Families for TBATA Gene

Protein Domains for TBATA Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96M53

UniProtKB/Swiss-Prot:

TBATA_HUMAN :
  • Belongs to the TBATA family.
Family:
  • Belongs to the TBATA family.
genes like me logo Genes that share domains with TBATA: view

No data available for Gene Families for TBATA Gene

Function for TBATA Gene

Molecular function for TBATA Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.
genes like me logo Genes that share phenotypes with TBATA: view

Animal Models for TBATA Gene

MGI Knock Outs for TBATA:

Animal Model Products

miRNA for TBATA Gene

miRTarBase miRNAs that target TBATA

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBATA Gene

Localization for TBATA Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBATA Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBATA Gene COMPARTMENTS Subcellular localization image for TBATA gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TBATA Gene

Pathways & Interactions for TBATA Gene

SuperPathways for TBATA Gene

No Data Available

Interacting Proteins for TBATA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299290%0d%0a9606.ENSP00000354340%0d%0a
Selected Interacting proteins: ENSP00000299290 for TBATA Gene via STRING

Symbol External ID(s) Details
UBA3

Gene Ontology (GO) - Biological Process for TBATA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TBATA: view

No data available for Pathways by source and SIGNOR curated interactions for TBATA Gene

Drugs & Compounds for TBATA Gene

No Compound Related Data Available

Transcripts for TBATA Gene

mRNA/cDNA for TBATA Gene

Unigene Clusters for TBATA Gene

Thymus, brain and testes associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBATA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - -
SP8: - - -
SP9: - - - -
SP10: - -
SP11: - - - - - - - - - -
SP12:
SP13: - - -
SP14: - - -

ExUns: 11 ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TBATA Gene

GeneLoc Exon Structure for
TBATA
ECgene alternative splicing isoforms for
TBATA

Expression for TBATA Gene

mRNA expression in normal human tissues for TBATA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBATA Gene

This gene is overexpressed in Testis (x47.1).

Protein differential expression in normal tissues from HIPED for TBATA Gene

This gene is overexpressed in Cerebrospinal fluid (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBATA Gene



SOURCE GeneReport for Unigene cluster for TBATA Gene Hs.386698

genes like me logo Genes that share expression patterns with TBATA: view

Protein tissue co-expression partners for TBATA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TBATA Gene

Orthologs for TBATA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBATA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBATA 35
  • 81.91 (n)
  • 75.61 (a)
TBATA 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBATA 35
  • 81.32 (n)
  • 76.15 (a)
TBATA 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbata 35
  • 74.22 (n)
  • 65.99 (a)
Tbata 16
Tbata 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBATA 35
  • 98.67 (n)
  • 97.55 (a)
TBATA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbata 35
  • 72.53 (n)
  • 62.82 (a)
oppossum
(Monodelphis domestica)
Mammalia TBATA 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBATA 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBATA 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731705 35
  • 54.6 (n)
  • 50 (a)
Str.15612 35
zebrafish
(Danio rerio)
Actinopterygii tbata 35
  • 48.71 (n)
  • 39.73 (a)
tbata 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7069 36
  • 23 (a)
OneToOne
Species with no ortholog for TBATA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBATA Gene

ENSEMBL:
Gene Tree for TBATA (if available)
TreeFam:
Gene Tree for TBATA (if available)

Paralogs for TBATA Gene

(1) SIMAP similar genes for TBATA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TBATA: view

No data available for Paralogs for TBATA Gene

Variants for TBATA Gene

Sequence variations from dbSNP and Humsavar for TBATA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2254174 - 70,775,251(+) GGATC(C/T)GACAC intron-variant, nc-transcript-variant, reference, missense
rs1538677 -- 70,783,823(-) TCTCA(C/T)ACTGA intron-variant, upstream-variant-2KB
rs1538680 -- 70,781,308(-) GCTGC(A/T)GTGGG intron-variant
rs1880055 -- 70,781,091(+) CTCCT(C/G)TCCTA intron-variant
rs3824762 -- 70,785,831(-) CAGCT(A/G)TCATG upstream-variant-2KB

Variation tolerance for TBATA Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBATA Gene

HapMap Linkage Disequilibrium report
TBATA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBATA Gene

Disorders for TBATA Gene

Relevant External Links for TBATA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBATA

No disorders were found for TBATA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBATA Gene

Publications for TBATA Gene

  1. Tbata modulates thymic stromal cell proliferation and thymus function. (PMID: 20937703) Flomerfelt F.A. … Gress R.E. (J. Exp. Med. 2010) 2 3 67
  2. Peptides presented by HLA class I molecules in the human thymus. (PMID: 24029068) Espinosa G. … Alvarez I. (J Proteomics 2013) 3
  3. Spatial (Tbata) expression in mature medullary thymic epithelial cells. (PMID: 19918778) Saade M. … Nguyen C. (Eur. J. Immunol. 2010) 3
  4. Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis. (PMID: 18208870) Goertsches R. … Comabella M. (Mult. Scler. 2008) 3
  5. Neuronal distribution of spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. (PMID: 17961552) Irla M. … Nguyen C. (Exp. Cell Res. 2007) 3

Products for TBATA Gene

Sources for TBATA Gene

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