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Aliases for TAX1BP3 Gene

Aliases for TAX1BP3 Gene

  • Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3 2 3
  • Tax Interaction Protein 1 2 3 4
  • Glutaminase-Interacting Protein 3 3 4
  • Tax-Interacting Protein 1 3 4
  • TIP-1 3 4
  • Tax1-Binding Protein 3 3
  • TIP1 4

External Ids for TAX1BP3 Gene

Summaries for TAX1BP3 Gene

GeneCards Summary for TAX1BP3 Gene

TAX1BP3 (Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG) and Cellular Transformation by HTLV1. GO annotations related to this gene include protein C-terminus binding and beta-catenin binding.

UniProtKB/Swiss-Prot for TAX1BP3 Gene

  • May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

Gene Wiki entry for TAX1BP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAX1BP3 Gene

Genomics for TAX1BP3 Gene

Genomic Location for TAX1BP3 Gene

Start:
3,662,893 bp from pter
End:
3,668,682 bp from pter
Size:
5,790 bases
Orientation:
Minus strand

Genomic View for TAX1BP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAX1BP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAX1BP3 Gene

Regulatory Elements for TAX1BP3 Gene

Proteins for TAX1BP3 Gene

  • Protein details for TAX1BP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14907-TX1B3_HUMAN
    Recommended name:
    Tax1-binding protein 3
    Protein Accession:
    O14907
    Secondary Accessions:
    • B2RD53
    • D3DTJ6
    • Q7LCQ4

    Protein attributes for TAX1BP3 Gene

    Size:
    124 amino acids
    Molecular mass:
    13735 Da
    Quaternary structure:
    • Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with HTLV-1 TAX protein. Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding.
    SequenceCaution:
    • Sequence=AAF43104.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAX1BP3 Gene

neXtProt entry for TAX1BP3 Gene

Proteomics data for TAX1BP3 Gene at MOPED

Post-translational modifications for TAX1BP3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys116

Other Protein References for TAX1BP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAX1BP3 Gene

Domains for TAX1BP3 Gene

Protein Domains for TAX1BP3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TX1B3_HUMAN
Domain:
  • Contains 1 PDZ (DHR) domain.:
    • O14907
genes like me logo Genes that share domains with TAX1BP3: view

No data available for Gene Families for TAX1BP3 Gene

Function for TAX1BP3 Gene

Molecular function for TAX1BP3 Gene

UniProtKB/Swiss-Prot Function: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

Gene Ontology (GO) - Molecular Function for TAX1BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10940294
GO:0008013 beta-catenin binding IEA --
GO:0008022 protein C-terminus binding IPI 16855024
genes like me logo Genes that share ontologies with TAX1BP3: view

Phenotypes for TAX1BP3 Gene

GenomeRNAi human phenotypes for TAX1BP3:
genes like me logo Genes that share phenotypes with TAX1BP3: view

miRNA for TAX1BP3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAX1BP3 Gene

Localization for TAX1BP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAX1BP3 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAX1BP3 Gene COMPARTMENTS Subcellular localization image for TAX1BP3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAX1BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm NAS 10940294
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with TAX1BP3: view

Pathways for TAX1BP3 Gene

genes like me logo Genes that share pathways with TAX1BP3: view

Pathways by source for TAX1BP3 Gene

1 Qiagen pathway for TAX1BP3 Gene
1 BioSystems pathway for TAX1BP3 Gene

Gene Ontology (GO) - Biological Process for TAX1BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction IDA 10940294
GO:0008285 negative regulation of cell proliferation IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030111 regulation of Wnt signaling pathway --
genes like me logo Genes that share ontologies with TAX1BP3: view

Transcripts for TAX1BP3 Gene

mRNA/cDNA for TAX1BP3 Gene

Unigene Clusters for TAX1BP3 Gene

Tax1 (human T-cell leukemia virus type I) binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAX1BP3 Gene

No ASD Table

Relevant External Links for TAX1BP3 Gene

GeneLoc Exon Structure for
TAX1BP3
ECgene alternative splicing isoforms for
TAX1BP3

Expression for TAX1BP3 Gene

mRNA expression in normal human tissues for TAX1BP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAX1BP3 Gene

SOURCE GeneReport for Unigene cluster for TAX1BP3 Gene Hs.12956

mRNA Expression by UniProt/SwissProt for TAX1BP3 Gene

O14907-TX1B3_HUMAN
Tissue specificity: Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.
genes like me logo Genes that share expressions with TAX1BP3: view

Orthologs for TAX1BP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAX1BP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAX1BP3 37
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAX1BP3 36
  • 94.09 (n)
  • 99.19 (a)
TAX1BP3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAX1BP3 36
  • 94.35 (n)
  • 100 (a)
TAX1BP3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tax1bp3 36
  • 90.05 (n)
  • 99.19 (a)
Tax1bp3 16
Tax1bp3 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAX1BP3 37
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAX1BP3 36
  • 82.53 (n)
  • 94.35 (a)
TAX1BP3 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76248 36
tax1bp3 36
  • 77.87 (n)
  • 90.98 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8275 36
zebrafish
(Danio rerio)
Actinopterygii Dr.4788 36
tax1bp3 36
  • 75.07 (n)
  • 83.74 (a)
tax1bp3 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3402 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C45G9.7 37
  • 40 (a)
OneToOne
Species with no ortholog for TAX1BP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAX1BP3 Gene

ENSEMBL:
Gene Tree for TAX1BP3 (if available)
TreeFam:
Gene Tree for TAX1BP3 (if available)

Paralogs for TAX1BP3 Gene

Selected SIMAP similar genes for TAX1BP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAX1BP3: view

No data available for Paralogs for TAX1BP3 Gene

Variants for TAX1BP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAX1BP3 Gene

Variant ID Type Subtype PubMed ID
nsv907565 CNV Loss 21882294
dgv358n27 CNV Loss 19166990
nsv833342 CNV Loss 17160897
nsv1947 CNV Insertion 18451855
nsv907569 CNV Loss 21882294

Relevant External Links for TAX1BP3 Gene

HapMap Linkage Disequilibrium report
TAX1BP3

No data available for Sequence variations from dbSNP and Humsavar for TAX1BP3 Gene

Disorders for TAX1BP3 Gene

No disorders were found for TAX1BP3 Gene.

No data available for UniProtKB/Swiss-Prot for TAX1BP3 Gene

Publications for TAX1BP3 Gene

  1. The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. (PMID: 10673275) Touchman J.W. … Green E.D. (Genome Res. 2000) 2 3 4
  2. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PMID: 10940294) Reynaud C. … Jalinot P. (J. Biol. Chem. 2000) 3 4
  3. The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. (PMID: 11163757) Olalla L. … Marquez J. (FEBS Lett. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAX1BP3 Gene

Sources for TAX1BP3 Gene

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