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Aliases for TAX1BP1 Gene

Aliases for TAX1BP1 Gene

  • Tax1 Binding Protein 1 2 3
  • Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1 2 3 5
  • TRAF6-Binding Protein 3 4
  • T6BP 3 4
  • CALCOCO3 3
  • TXBP151 3

External Ids for TAX1BP1 Gene

Previous GeneCards Identifiers for TAX1BP1 Gene

  • GC07P027422
  • GC07P027522
  • GC07P027553

Summaries for TAX1BP1 Gene

Entrez Gene Summary for TAX1BP1 Gene

  • This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for TAX1BP1 Gene

TAX1BP1 (Tax1 Binding Protein 1) is a Protein Coding gene. Diseases associated with TAX1BP1 include t-cell leukemia. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include kinase binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot for TAX1BP1 Gene

  • Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Gene Wiki entry for TAX1BP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAX1BP1 Gene

Genomics for TAX1BP1 Gene

Regulatory Elements for TAX1BP1 Gene

Promoters for TAX1BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAX1BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAX1BP1 Gene

Chromosome:
7
Start:
27,739,331 bp from pter
End:
27,844,564 bp from pter
Size:
105,234 bases
Orientation:
Plus strand

Genomic View for TAX1BP1 Gene

Genes around TAX1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAX1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAX1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAX1BP1 Gene

Proteins for TAX1BP1 Gene

  • Protein details for TAX1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VP1-TAXB1_HUMAN
    Recommended name:
    Tax1-binding protein 1
    Protein Accession:
    Q86VP1
    Secondary Accessions:
    • A4D196
    • B4DKU7
    • E7ENV2
    • O60398
    • O95770
    • Q13311
    • Q9BQG5
    • Q9UI88

    Protein attributes for TAX1BP1 Gene

    Size:
    789 amino acids
    Molecular mass:
    90877 Da
    Quaternary structure:
    • Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.
    SequenceCaution:
    • Sequence=AAC13359.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAX1BP1 Gene

    Alternative splice isoforms for TAX1BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAX1BP1 Gene

Proteomics data for TAX1BP1 Gene at MOPED

Post-translational modifications for TAX1BP1 Gene

  • Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.
  • Ubiquitination at Lys 465 and Lys 561
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TAX1BP1 (TAX1BP1)

No data available for DME Specific Peptides for TAX1BP1 Gene

Domains & Families for TAX1BP1 Gene

Protein Domains for TAX1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VP1

UniProtKB/Swiss-Prot:

TAXB1_HUMAN :
  • The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.
  • Contains 2 UBZ-type zinc fingers.
Domain:
  • The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.
Similarity:
  • Contains 2 UBZ-type zinc fingers.
genes like me logo Genes that share domains with TAX1BP1: view

No data available for Gene Families for TAX1BP1 Gene

Function for TAX1BP1 Gene

Molecular function for TAX1BP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Gene Ontology (GO) - Molecular Function for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding ISS --
genes like me logo Genes that share ontologies with TAX1BP1: view
genes like me logo Genes that share phenotypes with TAX1BP1: view

Animal Models for TAX1BP1 Gene

MGI Knock Outs for TAX1BP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAX1BP1 Gene

Localization for TAX1BP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAX1BP1 Gene COMPARTMENTS Subcellular localization image for TAX1BP1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TAX1BP1 Gene

Pathways & Interactions for TAX1BP1 Gene

genes like me logo Genes that share pathways with TAX1BP1: view

Pathways by source for TAX1BP1 Gene

SIGNOR curated interactions for TAX1BP1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with TAX1BP1: view

Drugs & Compounds for TAX1BP1 Gene

No Compound Related Data Available

Transcripts for TAX1BP1 Gene

Unigene Clusters for TAX1BP1 Gene

Tax1 (human T-cell leukemia virus type I) binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAX1BP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - - -

Relevant External Links for TAX1BP1 Gene

GeneLoc Exon Structure for
TAX1BP1
ECgene alternative splicing isoforms for
TAX1BP1

Expression for TAX1BP1 Gene

mRNA expression in normal human tissues for TAX1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAX1BP1 Gene

This gene is overexpressed in Uterus (27.8) and Cardia (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAX1BP1 Gene



SOURCE GeneReport for Unigene cluster for TAX1BP1 Gene Hs.34576

mRNA Expression by UniProt/SwissProt for TAX1BP1 Gene

Q86VP1-TAXB1_HUMAN
Tissue specificity: Expressed in all tissues tested.
genes like me logo Genes that share expression patterns with TAX1BP1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TAX1BP1 Gene

Orthologs for TAX1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAX1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAX1BP1 35
  • 91.68 (n)
  • 91.51 (a)
TAX1BP1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAX1BP1 35
  • 92.34 (n)
  • 93.27 (a)
TAX1BP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tax1bp1 35
  • 87.04 (n)
  • 87.55 (a)
Tax1bp1 16
Tax1bp1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAX1BP1 35
  • 99.54 (n)
  • 98.99 (a)
TAX1BP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tax1bp1 35
  • 87 (n)
  • 87.04 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAX1BP1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAX1BP1 35
  • 76.28 (n)
  • 74.87 (a)
TAX1BP1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAX1BP1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76179 35
tax1bp1 35
  • 68.89 (n)
  • 65.6 (a)
zebrafish
(Danio rerio)
Actinopterygii tax1bp1b 35
  • 59.41 (n)
  • 55.83 (a)
wufc20c12 35
tax1bp1a 36
  • 45 (a)
OneToMany
tax1bp1b 36
  • 50 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10595 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.823 36
  • 23 (a)
OneToMany
Species with no ortholog for TAX1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAX1BP1 Gene

ENSEMBL:
Gene Tree for TAX1BP1 (if available)
TreeFam:
Gene Tree for TAX1BP1 (if available)

Paralogs for TAX1BP1 Gene

Paralogs for TAX1BP1 Gene

(2) SIMAP similar genes for TAX1BP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TAX1BP1: view

Variants for TAX1BP1 Gene

Sequence variations from dbSNP and Humsavar for TAX1BP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11540483 - 27,787,484(+) AAAAT(A/C/T)TAGAT reference, missense
VAR_035665 A breast cancer sample
rs7809260 - 27,758,041(+) ATGGA(A/G)TACTG reference, missense, utr-variant-5-prime
rs9829 -- 27,765,958(+) CTGCT(C/T)ACTAT intron-variant, reference, synonymous-codon
rs11091 -- 27,827,757(+) GCCTA(C/T)TGCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAX1BP1 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
esv2603706 CNV Deletion 19546169
esv2172029 CNV Deletion 18987734
esv993269 CNV Deletion 20482838
esv1133870 CNV Deletion 17803354
esv2734172 CNV Deletion 23290073
dgv2072e1 CNV Complex 17122850
esv989626 CNV Insertion 20482838
nsv5677 CNV Loss 18451855

Variation tolerance for TAX1BP1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAX1BP1 Gene

HapMap Linkage Disequilibrium report
TAX1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAX1BP1 Gene

Disorders for TAX1BP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAX1BP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TAX1BP1

Genetic Association Database (GAD)
TAX1BP1
Human Genome Epidemiology (HuGE) Navigator
TAX1BP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAX1BP1
genes like me logo Genes that share disorders with TAX1BP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAX1BP1 Gene

Publications for TAX1BP1 Gene

  1. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. (PMID: 10435631) de Valck D. … Beyaert R. (Oncogene 1999) 2 3 4 67
  2. NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. (PMID: 19609363) Journo C. … Weil R. (PLoS Pathog. 2009) 3 23
  3. Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit. (PMID: 16999686) Ulrich M. … Enz R. (Biochem. J. 2007) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TAX1BP1 Gene

Sources for TAX1BP1 Gene

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