Aliases for TAX1BP1 Gene
External Ids for TAX1BP1 Gene
Previous GeneCards Identifiers for TAX1BP1 Gene
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
GeneCards Summary for TAX1BP1 Gene
TAX1BP1 (Tax1 Binding Protein 1) is a Protein Coding gene. Diseases associated with TAX1BP1 include T-Cell Leukemia. Among its related pathways are TNF signaling (REACTOME) and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include kinase binding. An important paralog of this gene is CALCOCO1.
UniProtKB/Swiss-Prot for TAX1BP1 Gene
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.