Aliases for TAX1BP1 Gene
External Ids for TAX1BP1 Gene
Previous GeneCards Identifiers for TAX1BP1 Gene
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
GeneCards Summary for TAX1BP1 Gene
TAX1BP1 (Tax1 Binding Protein 1) is a Protein Coding gene. Diseases associated with TAX1BP1 include T-Cell Leukemia. Among its related pathways are Apoptosis and Autophagy and Innate Immune System. GO annotations related to this gene include kinase binding. An important paralog of this gene is CALCOCO1.
UniProtKB/Swiss-Prot for TAX1BP1 Gene
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.