Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TAX1BP1 Gene

protein-coding   GIFtS: 61
GCID: GC07P027746

Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein...

  See TAX1BP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 11 2
T6BP2 3
TRAF6-Binding Protein2 3
TXBP1512 5
CALCOCO32
Tax1-Binding Protein 12

External Ids:    HGNC: 115751   Entrez Gene: 88872   Ensembl: ENSG000001060527   OMIM: 6053265   UniProtKB: Q86VP13   

Export aliases for TAX1BP1 gene to outside databases

Previous GC identifers: GC07P027422 GC07P027522 GC07P027553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TAX1BP1 Gene:
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits
TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by
caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in
the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.(provided by RefSeq, May 2011)

GeneCards Summary for TAX1BP1 Gene:
TAX1BP1 (Tax1 (human T-cell leukemia virus type I) binding protein 1) is a protein-coding gene. Diseases associated with TAX1BP1 include t-cell leukemia. GO annotations related to this gene include kinase binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1
Function: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by
caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine
IL-1 signaling cascade

Gene Wiki entry for TAX1BP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAX1BP1 gene promoter:
         AML1a   XBP-1   POU6F1 (c2)   CUTL1   Nkx2-5   CREB   POU2F1   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): TAX1BP1 promoter sequence
   Search Chromatin IP Primers for TAX1BP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAX1BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15

TAX1BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAX1BP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P027746:  view genomic region     (about GC identifiers)

Start:
27,778,950 bp from pter      End:
27,884,183 bp from pter
Size:
105,234 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 27,830,108-27,920,146     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1 (See protein sequence)
Recommended Name: Tax1-binding protein 1  
Size: 789 amino acids; 90877 Da
Subunit: Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with
STARD13. Interacts with the HTLV-1 protein Tax-1
Sequence caution: Sequence=AAC13359.2; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for TAX1BP1:
2M7Q (3D)        4BMJ (3D)    
Secondary accessions: B4DKU7 E7ENV2 O60398 O95770 Q13311 Q9BQG5 Q9UI88
Alternative splicing: 4 isoforms:  Q86VP1-1   Q86VP1-2   Q86VP1-3   Q86VP1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAX1BP1: NX_Q86VP1

Explore proteomics data for TAX1BP1 at MOPED

Post-translational modifications: 

  • Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation1
  • Ubiquitination2 at Lys465, Lys561
  • Modification sites at PhosphoSitePlus

  • See TAX1BP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001073333.1  NP_001193830.1  NP_001193831.1  NP_006015.4  

    ENSEMBL proteins: 
     ENSP00000411490   ENSP00000395290   ENSP00000265393   ENSP00000386515   ENSP00000391215  
     ENSP00000379612   ENSP00000412575   ENSP00000477282   ENSP00000444811   ENSP00000391907  
    Reactome Protein details: Q86VP1

    TAX1BP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TAX1BP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TAX1BP1
    GenScript Custom Purified and Recombinant Proteins Services for TAX1BP1
    Novus Biologicals TAX1BP1 Proteins
    Novus Biologicals TAX1BP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAX1BP1

     
    Search eBioscience for Proteins for TAX1BP1 

    TAX1BP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TAX1BP1 
    OriGene Antibodies for TAX1BP1
    OriGene Custom Antibody Services for TAX1BP1
    Novus Biologicals TAX1BP1 Antibodies
    Abcam antibodies for TAX1BP1
    Cloud-Clone Corp. Antibodies for TAX1BP1
    ThermoFisher Antibodies for TAX1BP1
    LSBio Antibodies in human, mouse, rat for TAX1BP1

    TAX1BP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAX1BP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAX1BP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAX1BP1
    Cloud-Clone Corp. CLIAs for TAX1BP1
    Search eBioscience for ELISAs for TAX1BP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q86VP1

    ProtoNet protein and cluster: Q86VP1

    1 Blocks protein domain: IPB012852 Coiled-coil transcriptional coactivator-like


    Find genes that share domains with TAX1BP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAXB1_HUMAN, Q86VP1
    Function: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by
    caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine
    IL-1 signaling cascade

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10920205
    GO:0019900kinase binding ISS--
         
    Find genes that share ontologies with TAX1BP1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TAX1BP1:
     Decreased POU5F1-GFP protein e  Decreased viability with pacli  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tax1bp1):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  immune system 
     integument  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with TAX1BP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TAX1BP1: Tax1bp1tm1Ktj Tax1bp1tm1Djin

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAX1BP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAX1BP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAX1BP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAX1BP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAX1BP1:
    hsa-mir-130b-3p (MIRT020162), hsa-mir-93-5p (MIRT028055)

    Block miRNA regulation of human, mouse, rat TAX1BP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TAX1BP1:
    hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidTAX1BP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAX1BP1
    Predesigned siRNA for gene silencing in human, mouse, rat TAX1BP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAX1BP1

    Clone
    Products:
         
    OriGene clones in human, mouse for TAX1BP1 (see all 12)
    OriGene ORF clones in mouse, rat for TAX1BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAX1BP1 (NM_006024)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAX1BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAX1BP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAX1BP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAX1BP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAX1BP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TAX1BP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TAX1BP1 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    2NF-kappaB Signaling
    NF-kappaB Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with TAX1BP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TAX1BP1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 Reactome Pathway for TAX1BP1
        Negative regulators of RIG-I/MDA5 signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including TAX1BP1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TAX1BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAX1BP1 (Q86VP11, 2, 3 ENSP000003796124) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K31, 2, 3EBI-529518,EBI-359276 MINT-6505191 MINT-5226512 MINT-6505206 MINT-6505175 MINT-6505156 I2D: score=8 
    STARD13Q9Y3M81, 3, ENSP000003387854EBI-529518,EBI-465487 I2D: score=5 STRING: ENSP00000338785
    TBC1D17Q9HA652, 3MINT-65532 I2D: score=4 
    UBCP0CG481, 2, 3, ENSP000003448184EBI-529518,EBI-3390054 MINT-6505092 MINT-6505052 MINT-6505073 MINT-6505145 MINT-6505107 MINT-6505126 I2D: score=3 STRING: ENSP00000344818
    RALBP1Q153111, 2, 3, ENSP000000193174EBI-529518,EBI-749285 MINT-6505297 MINT-5226536 MINT-6505280 I2D: score=1 STRING: ENSP00000019317
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity ISS--
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with TAX1BP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAX1BP1 (TAXB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TAX1BP1 gene (4 alternative transcripts): 
    NM_001079864.2  NM_001206901.1  NM_001206902.1  NM_006024.6  

    Unigene Cluster for TAX1BP1:

    Tax1 (human T-cell leukemia virus type I) binding protein 1
    Hs.34576  [show with all ESTs]
    Unigene Representative Sequence: NM_006024
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418691 ENST00000422800 ENST00000265393 ENST00000409980 ENST00000416801
    ENST00000490455 ENST00000396319(uc003szk.3 uc003szl.3 uc011jzp.2)
    ENST00000494033 ENST00000457186 ENST00000488564 ENST00000460059 ENST00000543117(uc011jzo.2)
    ENST00000433216
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAX1BP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TAX1BP1:
    hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidTAX1BP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAX1BP1
    Predesigned siRNA for gene silencing in human, mouse, rat TAX1BP1
    Clone
    Products:
         
    OriGene clones in human, mouse for TAX1BP1 (see all 12)
    OriGene ORF clones in mouse, rat for TAX1BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAX1BP1 (NM_006024)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAX1BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAX1BP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TAX1BP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAX1BP1
      QuantiTect SYBR Green Assays in human, mouse, rat TAX1BP1
      QuantiFast Probe-based Assays in human, mouse, rat TAX1BP1

    Additional mRNA sequence: 

    AF090891.1 AF268075.1 AK000098.1 AK296720.1 AK299729.1 AK301064.1 AK309757.1 AK314292.1 
    AL136586.1 BC024600.1 BC050358.2 CR457056.1 CR533556.1 U33821.2 

    Selected DOTS entries (see all 34):

    DT.100685614  DT.100774622  DT.99974249  DT.95183505  DT.95183539  DT.100037964  DT.100802281  DT.100850247 
    DT.95141606  DT.121046134  DT.86854577  DT.121046241  DT.100850246  DT.121046348  DT.100669466  DT.100850236 
    DT.100850243  DT.95106304  DT.121046248  DT.121046295  DT.91763441  DT.91886245  DT.95183487  DT.95183489 

    Selected AceView cDNA sequences (see all 721):

    AA481381 AI673719 CB138720 CR602905 AI247564 AW068925 H89626 AI110675 
    AU138980 AV711263 CR619985 N80399 AA872943 CB154047 BU077892 AI954229 
    BM851125 BX394278 AA233590 AA256888 BM464161 AA448383 CK822085 BC024600 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAX1BP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                          -                                                                                   -                       -                     
    SP2:                          -                                                                                                           -                     
    SP3:                                                                                                              -                       -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for TAX1BP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TAX1BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGACCCA
    TAX1BP1 Expression
    About this image


    TAX1BP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Colon (Gastrointestinal Tract)
    TAX1BP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAX1BP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34576

    UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1
    Tissue specificity: Expressed in all tissues tested

        Pathway & Disease-focused RT2 Profiler PCR Array including TAX1BP1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAX1BP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAX1BP1
    QuantiTect SYBR Green Assays in human, mouse, rat TAX1BP1
    QuantiFast Probe-based Assays in human, mouse, rat TAX1BP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAX1BP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TAX1BP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tax1bp11 , 5 Tax1 (human T cell leukemia virus type I) binding protein more1, 5 87.04(n)1
    87.55(a)1
      6 (25.70 cM)5
    524401  NM_025816.31  NP_080092.21 
     527137295 
    chicken
    (Gallus gallus)
    Aves TAX1BP11 Tax1 (human T-cell leukemia virus type I) binding protein more 76.28(n)
    74.87(a)
      395490  NM_204738.1  NP_990069.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAX1BP16
    Tax1 (human T-cell leukemia virus type I) binding ...
    66(a)
    1 ↔ 1
    GL343275.1(944544-979342)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA973309.12   -- 76.6(n)    CA973309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc20c122 Danio rerio cDNA clone MGC73219 IMAGE4143696, complete more 76.88(n)    BC060918.1 


    ENSEMBL Gene Tree for TAX1BP1 (if available)
    TreeFam Gene Tree for TAX1BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TAX1BP1 gene
    CALCOCO22  CALCOCO12  
    2 SIMAP similar genes for TAX1BP1 using alignment to 9 protein entries:     TAXB1_HUMAN (see all proteins):
    CALCOCO2    CALCOCO1

    Find genes that share paralogs with TAX1BP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TAX1BP1 (see all 1600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356654
    A breast cancer sample4--see VAR_0356652 Q R mis40--------
    rs47227391,2
    C,F,A,H--27752652(+) TTCACC/TATTCA 4 -- int120Minor allele frequency- T:0.43NS EA NA WA 2346
    rs1890410821,2
    --27752675(+) TGCTTC/GGTGTT 4 -- int10--------
    rs47227401,2
    C,F,A,H--27752692(+) GCCAGT/CGAGCG 4 -- int117Minor allele frequency- C:0.17NS EA NA WA 1346
    rs1930077271,2
    --27752701(+) CGTTCA/TTGAAT 4 -- int10--------
    rs1503933081,2
    C--27752711(+) TCTCT-/AAGAGA 4 -- int10--------
    rs1845084391,2
    --27753005(+) ATGAGC/TGAGAG 4 -- int10--------
    rs1890322841,2
    --27753096(+) ATGTAC/TATTCG 4 -- int10--------
    rs1384423421,2
    C--27753101(+) ATTCG-/TTATAC 4 -- int10--------
    rs1431959261,2
    --27753145(+) CCCCAA/GTCCCA 4 -- int10--------

    HapMap Linkage Disequilibrium report for TAX1BP1 (27778950 - 27884183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TAX1BP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734172CNV Deletion23290073
    esv993269CNV Deletion20482838
    esv2603706CNV Deletion19546169
    esv2172029CNV Deletion18987734
    esv1133870CNV Deletion17803354
    esv989626CNV Insertion20482838
    nsv5677CNV Loss18451855
    dgv2072e1CNV Complex17122850
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAX1BP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAX1BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605326    OMIM disorders: --

    1 disease for TAX1BP1:    
    About MalaCards
    t-cell leukemia


    Find genes that share disorders with TAX1BP1           About GenesLikeMe

    Genetic Association Database (GAD): TAX1BP1
    Human Genome Epidemiology (HuGE) Navigator: TAX1BP1 (3 documents)

    Export disorders for TAX1BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TAX1BP1 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with TAX1BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. (PubMed id 10435631)1, 2, 3 de Valck D.... Beyaert R. (Oncogene 1999)
    2. Analysis of the TAX1BP1 gene in head and neck cancer patients. (PubMed id 20549079)1, 4 Ruiz M.T....Goloni-Bertollo E.M. (Braz J Otorhinolaryngol 2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    5. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)1, 2 Nagaraja G.M. and Kandpal R.P. (Biochem. Biophys. Res. Commun. 2004)
    6. Protein profile of tax-associated complexes. (PubMed id 14530271)1, 2 Wu K.... Kashanchi F. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. (PubMed id 10920205)1, 2 Ling L. and Goeddel D.V. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8887 HGNC: 11575 AceView: TAX1BP1 Ensembl:ENSG00000106052 euGenes: HUgn8887
    ECgene: TAX1BP1 H-InvDB: TAX1BP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TAX1BP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAX1BP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAX1BP1 gene:
    Search GeneIP for patents involving TAX1BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TAX1BP1   OriGene RNAi products in human, mouse, rat for TAX1BP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TAX1BP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAX1BP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAX1BP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAX1BP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAX1BP1   OriGene Custom Protein Services for TAX1BP1  

     
     
     Block miRNA regulation of human, mouse, rat TAX1BP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TAX1BP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAX1BP1 Predesigned siRNA for gene silencing in human, mouse, rat TAX1BP1
     QuantiFast Probe-based Assays in human, mouse, rat TAX1BP1 QuantiTect SYBR Green Assays in human, mouse, rat TAX1BP1
     PCR Arrays including human, mouse, rat TAX1BP1 Search Chromatin IP Primers for TAX1BP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAX1BP1  GeneGlobe Interaction Network for TAX1BP1
     Regulatory tfbs in TAX1BP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TAX1BP1 GenScript cDNA clones with any tag delivered in your preferred vector for TAX1BP1
     GenScript Custom Assay Services for TAX1BP1 GenScript Custom overexpressing Cell Line Services for TAX1BP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TAX1BP1 

     Search Tocris compounds for TAX1BP1 (TAXB1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TAX1BP1 antibodies
     TAX1BP1 proteins
     TAX1BP1 lysates
     Antibodies for TAX1BP1
     See all of Abcam's Antibodies, Kits and Proteins for TAX1BP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TAX1BP1
     Antibodies for TAX1BP1
     ELISAs for TAX1BP1
     CLIAs for TAX1BP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TAX1BP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAX1BP1
     SwitchGear 3'UTR luciferase reporter plasmids for TAX1BP1
     SwitchGear Promoter luciferase reporter plasmids for TAX1BP1
     ThermoFisher Antibodies for TAX1BP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAX1BP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAX1BP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAX1BP1
     LSBio Antibodies in human, mouse, rat for TAX1BP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TAX1BP1
      Search eBioscience for proteins for TAX1BP1
      Search eBioscience for elisas for TAX1BP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAX1BP1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4