Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAX1BP1 Gene

Aliases for TAX1BP1 Gene

  • Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1 2 3
  • TRAF6-Binding Protein 3 4
  • TXBP151 3 6
  • T6BP 3 4
  • Tax1-Binding Protein 1 3
  • CALCOCO3 3

External Ids for TAX1BP1 Gene

Summaries for TAX1BP1 Gene

Entrez Gene Summary for TAX1BP1 Gene

  • This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for TAX1BP1 Gene

TAX1BP1 (Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1) is a Protein Coding gene. Diseases associated with TAX1BP1 include t-cell leukemia. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. GO annotations related to this gene include kinase binding. An important paralog of this gene is CALCOCO2.

UniProtKB/Swiss-Prot for TAX1BP1 Gene

  • Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Gene Wiki entry for TAX1BP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAX1BP1 Gene

Genomics for TAX1BP1 Gene

Genomic Location for TAX1BP1 Gene

Start:
27,739,331 bp from pter
End:
27,844,564 bp from pter
Size:
105,234 bases
Orientation:
Plus strand

Genomic View for TAX1BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAX1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAX1BP1 Gene

Regulatory Elements for TAX1BP1 Gene

Proteins for TAX1BP1 Gene

  • Protein details for TAX1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VP1-TAXB1_HUMAN
    Recommended name:
    Tax1-binding protein 1
    Protein Accession:
    Q86VP1
    Secondary Accessions:
    • A4D196
    • B4DKU7
    • E7ENV2
    • O60398
    • O95770
    • Q13311
    • Q9BQG5
    • Q9UI88

    Protein attributes for TAX1BP1 Gene

    Size:
    789 amino acids
    Molecular mass:
    90877 Da
    Quaternary structure:
    • Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.
    SequenceCaution:
    • Sequence=AAC13359.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAX1BP1 Gene

    Alternative splice isoforms for TAX1BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAX1BP1 Gene

Proteomics data for TAX1BP1 Gene at MOPED

Post-translational modifications for TAX1BP1 Gene

  • Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys465 and Lys561

No data available for DME Specific Peptides for TAX1BP1 Gene

Domains for TAX1BP1 Gene

Protein Domains for TAX1BP1 Gene

UniProtKB/Swiss-Prot:

TAXB1_HUMAN
Domain:
  • The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.:
    • Q86VP1
Similarity:
  • Contains 2 UBZ-type zinc fingers.:
    • Q86VP1
genes like me logo Genes that share domains with TAX1BP1: view

No data available for Gene Families for TAX1BP1 Gene

Function for TAX1BP1 Gene

Molecular function for TAX1BP1 Gene

UniProtKB/Swiss-Prot Function: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Gene Ontology (GO) - Molecular Function for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10920205
GO:0019900 kinase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TAX1BP1: view
genes like me logo Genes that share phenotypes with TAX1BP1: view

Animal Models for TAX1BP1 Gene

MGI Knock Outs for TAX1BP1:

miRNA for TAX1BP1 Gene

miRTarBase miRNAs that target TAX1BP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAX1BP1 Gene

Localization for TAX1BP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAX1BP1 Gene COMPARTMENTS Subcellular localization image for TAX1BP1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with TAX1BP1: view

Pathways for TAX1BP1 Gene

genes like me logo Genes that share pathways with TAX1BP1: view

Pathways by source for TAX1BP1 Gene

2 Cell Signaling Technology pathways for TAX1BP1 Gene

Gene Ontology (GO) - Biological Process for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity ISS --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with TAX1BP1: view

Transcripts for TAX1BP1 Gene

Unigene Clusters for TAX1BP1 Gene

Tax1 (human T-cell leukemia virus type I) binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAX1BP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - - -

Relevant External Links for TAX1BP1 Gene

GeneLoc Exon Structure for
TAX1BP1
ECgene alternative splicing isoforms for
TAX1BP1

Expression for TAX1BP1 Gene

mRNA expression in normal human tissues for TAX1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAX1BP1 Gene

SOURCE GeneReport for Unigene cluster for TAX1BP1 Gene Hs.34576

mRNA Expression by UniProt/SwissProt for TAX1BP1 Gene

Q86VP1-TAXB1_HUMAN
Tissue specificity: Expressed in all tissues tested
genes like me logo Genes that share expressions with TAX1BP1: view

Orthologs for TAX1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAX1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAX1BP1 36
  • 99.54 (n)
  • 98.99 (a)
TAX1BP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAX1BP1 36
  • 91.68 (n)
  • 91.51 (a)
TAX1BP1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAX1BP1 36
  • 92.34 (n)
  • 93.27 (a)
TAX1BP1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tax1bp1 36
  • 87.04 (n)
  • 87.55 (a)
Tax1bp1 16
Tax1bp1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAX1BP1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tax1bp1 36
  • 87 (n)
  • 87.04 (a)
chicken
(Gallus gallus)
Aves TAX1BP1 36
  • 76.28 (n)
  • 74.87 (a)
TAX1BP1 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAX1BP1 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76179 36
tax1bp1 36
  • 68.89 (n)
  • 65.6 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10595 36
zebrafish
(Danio rerio)
Actinopterygii tax1bp1a 37
  • 45 (a)
OneToMany
tax1bp1b 36
  • 59.41 (n)
  • 55.83 (a)
tax1bp1b 37
  • 50 (a)
OneToMany
wufc20c12 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.823 37
  • 23 (a)
OneToMany
Species with no ortholog for TAX1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAX1BP1 Gene

ENSEMBL:
Gene Tree for TAX1BP1 (if available)
TreeFam:
Gene Tree for TAX1BP1 (if available)

Paralogs for TAX1BP1 Gene

Paralogs for TAX1BP1 Gene

Selected SIMAP similar genes for TAX1BP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TAX1BP1: view

Variants for TAX1BP1 Gene

Sequence variations from dbSNP and Humsavar for TAX1BP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9829 -- 27,765,958(+) CTGCT(C/T)ACTAT synonymous-codon, reference, intron-variant
rs11091 -- 27,827,757(+) GCCTA(C/T)TGCTC reference, missense
rs471322 -- 27,742,288(-) aggta(G/T)tgtcc intron-variant
rs520382 -- 27,742,311(+) cagag(G/T)tccct intron-variant
rs1029604 -- 27,752,337(+) ATTGG(C/T)CTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAX1BP1 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
esv2603706 CNV Deletion 19546169
esv2172029 CNV Deletion 18987734
esv993269 CNV Deletion 20482838
esv1133870 CNV Deletion 17803354
esv2734172 CNV Deletion 23290073
dgv2072e1 CNV Complex 17122850
esv989626 CNV Insertion 20482838
nsv5677 CNV Loss 18451855

Relevant External Links for TAX1BP1 Gene

HapMap Linkage Disequilibrium report
TAX1BP1

Disorders for TAX1BP1 Gene

(1) MalaCards Diseases for TAX1BP1 Gene

Search for TAX1BP1 Gene in MalaCards »

Relevant External Links for TAX1BP1

Genetic Association Database (GAD)
TAX1BP1
Human Genome Epidemiology (HuGE) Navigator
TAX1BP1
genes like me logo Genes that share disorders with TAX1BP1: view

No data available for UniProtKB/Swiss-Prot for TAX1BP1 Gene

Publications for TAX1BP1 Gene

  1. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. (PMID: 10435631) de Valck D. … Beyaert R. (Oncogene 1999) 2 3 4
  2. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. (PMID: 10920205) Ling L. … Goeddel D.V. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit. (PMID: 16999686) Ulrich M. … Enz R. (Biochem. J. 2007) 3 23
  4. NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. (PMID: 19609363) Journo C. … Weil R. (PLoS Pathog. 2009) 3 23
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for TAX1BP1 Gene

Sources for TAX1BP1 Gene

Back to Top

Content