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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAX1BP1 Gene

protein-coding   GIFtS: 57
GCID: GC07P027746

Tax1 (human T-cell leukemia virus type I) binding protein...
 Explore 8 diseases affiliated with
TAX1BP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TAX1BP1    

Aliases
for TAX1BP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 11 2
TXBP1511 2 5
CALCOCO31 2
T6BP2 3
TRAF6-Binding Protein2 3
Tax1-Binding Protein 12

External Ids:    HGNC: 115751   Entrez Gene: 88872   Ensembl: ENSG000001060527   OMIM: 6053265   UniProtKB: Q86VP13   

Export aliases for TAX1BP1 gene to outside databases

Previous GC identifers: GC07P027422 GC07P027522 GC07P027553


Summaries
for TAX1BP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TAX1BP1:
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced
apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family
proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of
inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1
Function: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like
family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling
cascade

Gene Wiki entry for TAX1BP1


Genomic Views
for TAX1BP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAX1BP1 gene promoter:
         AML1a   XBP-1   POU6F1 (c2)   CUTL1   Nkx2-5   CREB   POU2F1   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): TAX1BP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAX1BP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAX1BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15

TAX1BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAX1BP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P027746:  view genomic region     (about GC identifiers)

Start:
 27,778,950 bp from pter      End:
 27,880,938 bp from pter
Size:
 101,989 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 27,830,854-27,920,146     

Proteins
for TAX1BP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1 (See protein sequence)
Recommended Name: Tax1-binding protein 1  
Size: 789 amino acids; 90877 Da
Subunit: Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13.
Interacts with the HTLV-1 protein Tax-1
Sequence caution: Sequence=AAC13359.2; Type=Erroneous gene model prediction;
Secondary accessions: B4DKU7 E7ENV2 O60398 O95770 Q13311 Q9BQG5 Q9UI88
Alternative splicing: 4 isoforms:  Q86VP1-1   Q86VP1-2   Q86VP1-3   Q86VP1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAX1BP1: NX_Q86VP1

Post-translational modifications:

  • Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VP1

    • TAX1BP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001073333.1  NP_001193830.1  NP_001193831.1  NP_006015.4  

    ENSEMBL proteins: 
     ENSP00000411490   ENSP00000395290   ENSP00000265393   ENSP00000386515   ENSP00000391215  
     ENSP00000379612   ENSP00000412575   ENSP00000444811   ENSP00000391907  
    Reactome Protein details: Q86VP1
    Human Recombinant Protein Products: 
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    Novus Biologicals TAX1BP1 Proteins
    Novus Biologicals TAX1BP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TAX1BP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--


    TAX1BP1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TAX1BP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TAX1BP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR012852 CoCoA

    Graphical View of Domain Structure for InterPro Entry Q86VP1

    ProtoNet protein and cluster: Q86VP1

    1 Blocks protein family: IPB012852 Coiled-coil transcriptional coactivator-like


    Function
    for TAX1BP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1
    Function: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like
    family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling
    cascade

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TAX1BP1

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15474016
    GO:0008270zinc ion binding IEA--
    GO:0019900kinase binding ISS--


    TAX1BP1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for TAX1BP1:
     Decreased POU5F1-GFP protein e  Decreased viability with pacli  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for TAX1BP1: Tax1bp1tm1Ktj Tax1bp1tm1Djin
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tax1bp1):
     cardiovascular system  cellular  growth/size  immune system  integument 
     mortality/aging  no phenotypic analysis 

    TAX1BP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TAX1BP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Innate Immune System0.46
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways1.00
    		Negative regulators of RIG-I/MDA5 signaling0.49
    3Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    4NF-kappaB Signaling
    		NF-kappaB Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TAX1BP1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    4        Reactome Pathways for TAX1BP1
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    Immune System
    Innate Immune System



    TAX1BP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAX1BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/31 Interacting proteins for TAX1BP1 (Q86VP11, 2, 3 ENSP000003796124) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K31, 2, 3EBI-529518,EBI-359276 MINT-6505191 MINT-5226512 MINT-6505206 MINT-6505175 MINT-6505156 I2D: score=8 
    STARD13Q9Y3M81, 3, ENSP000003387854EBI-529518,EBI-465487 I2D: score=5 STRING: ENSP00000338785
    TBC1D17Q9HA652, 3MINT-65532 I2D: score=4 
    UBCP0CG482, 3, ENSP000003448184MINT-6505092 MINT-6505052 MINT-6505073 MINT-6505145 MINT-6505107 MINT-6505126 I2D: score=3 STRING: ENSP00000344818
    RALBP1Q153112, 3, ENSP000000193174MINT-6505297 MINT-5226536 MINT-6505280 I2D: score=1 STRING: ENSP00000019317
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity ISS--
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0045087innate immune response TAS--


    TAX1BP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAX1BP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAX1BP1
    Search CenterWatch for drugs/clinical trials and news about TAX1BP1 / TAXB1 

    Transcripts
    for TAX1BP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TAX1BP1 gene (4 alternative transcripts): 
    NM_001079864.2  NM_001206901.1  NM_001206902.1  NM_006024.6  

    Unigene Cluster for TAX1BP1:

    Tax1 (human T-cell leukemia virus type I) binding protein 1
    Hs.34576  [show with all ESTs]
    Unigene Representative Sequence: NM_006024
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418691 ENST00000422800 ENST00000265393 ENST00000409980 ENST00000416801
    ENST00000490455 ENST00000396319(uc003szk.3 uc003szl.3 uc011jzp.2)
    ENST00000494033 ENST00000457186 ENST00000488564 ENST00000460059 ENST00000543117(uc011jzo.2)
    ENST00000433216

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TAX1BP1:
    hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmid: TAX1BP1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF090891.1 AF268075.1 AK000098.1 AK296720.1 AK299729.1 AK301064.1 AK309757.1 AK314292.1 
    AL136586.1 BC024600.1 BC050358.2 CR457056.1 CR533556.1 U33821.2 

    24/34 DOTS entries (see all 34):

    DT.100685614  DT.100774622  DT.99974249  DT.95183505  DT.95183539  DT.100037964  DT.100802281  DT.100850247 
    DT.95141606  DT.121046134  DT.86854577  DT.121046241  DT.100850246  DT.121046348  DT.100669466  DT.100850236 
    DT.100850243  DT.95106304  DT.121046244  DT.121046248  DT.121046295  DT.91763441  DT.91886245  DT.95183487 

    24/721 AceView cDNA sequences (see all 721):

    BM979704 CB853610 BU949994 BP375402 AA383721 BM769055 BX954752 BU680065 
    AF063549 BM968850 AI263840 AI247564 AW854758 CA419842 AL041212 AV702131 
    BC024600 AW468864 AA448383 CB306348 BM021502 BQ271093 AI826585 CB130288 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TAX1BP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                          -                                                                                   -                       -                     
    SP2:                          -                                                                                                           -                     
    SP3:                                                                                                              -                       -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for TAX1BP1

    Expression
    for TAX1BP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAX1BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAGACCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TAX1BP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TAX1BP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAX1BP1

    SOURCE GeneReport for Unigene cluster: Hs.34576

    UniProtKB/Swiss-Prot: TAXB1_HUMAN, Q86VP1
    Tissue specificity: Expressed in all tissues tested

        SABiosciences Expression via Pathway-Focused PCR Array including TAX1BP1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAX1BP1

    Orthologs
    for TAX1BP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TAX1BP1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TAX1BP11 Tax1 (human T-cell leukemia virus type I) binding protein more 76.37(n)
    74.87(a)    		   395490  NM_204738.1  NP_990069.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TAX1BP16
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343275.1(947034-970646)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA973309.12   -- 76.6(n)    CA973309.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc20c122 Danio rerio cDNA clone MGC73219 IMAGE4143696, complete more 76.88(n)    BC060918.1 


    ENSEMBL Gene Tree for TAX1BP1 (if available)
    TreeFam Gene Tree for TAX1BP1 (if available) 

    Paralogs
    for TAX1BP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAX1BP1 gene
    CALCOCO22  CALCOCO12  
    2 SIMAP similar genes for TAX1BP1 using alignment to 8 protein entries:     TAXB1_HUMAN (see all proteins):
    CALCOCO2    CALCOCO1

    TAX1BP1 for paralogs           About GeneDecksing



    Genomic Variants
    for TAX1BP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1555 NCBI SNPs in TAX1BP1 are shown (see all 1555)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs113362371,2
    		C,--27682532(+) GAGTT-/AAGAGA 4 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs1917376691,2
    		--27777171(+) CTCATA/GCCTGT 2 -- us2k1 int10--------
    rs597187841,2
    		C--27777288(+) GTCTC-/AAAAAA 2 -- int1 us2k12Minor allele frequency- A:0.00NA CSA 4
    rs1840382111,2
    		--27777472(+) TGTGAC/TATTCA 2 -- us2k1 int10--------
    rs1878567511,2
    		--27777683(+) ATTCAA/GTTAAA 2 -- us2k1 int10--------
    rs1385588031,2
    		--27777776(+) ACCAGC/TCTGGC 5 -- us2k1 int10--------
    rs1916025311,2
    		--27777834(+) GTGTGA/GTGGTG 5 -- us2k1 int10--------
    rs1493021901,2
    		--27777923(+) CGAGAA/TCATGC 5 -- us2k1 int10--------
    rs1823063721,2
    		--27777939(+) CACTAC/TACCCT 5 -- us2k1 int10--------
    rs1462535811,2
    		--27777957(+) AGAGCA/GAGACT 5 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for TAX1BP1 (27778950 - 27880938 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TAX1BP1
         2 CNVs: 99902 3672
         2 Indels: 28617 47330

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    Disorders / Diseases
    for TAX1BP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TAX1BP1 for disorders           About GeneDecksing

    OMIM gene information: 605326    OMIM disorders: --

    8 diseases for TAX1BP1:    About MalaCards
    t-cell leukemia    human t-cell leukemia virus type 1    leukemia    oral cavity cancer
    rheumatoid arthritis    arthritis    breast carcinoma    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: TAX1BP1 (3 documents)

    Export disorders for TAX1BP1 gene to outside databases

    Publications
    for TAX1BP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAX1BP1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with TAX1BP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. (PubMed id 10435631)1, 2, 3 de Valck D.... Beyaert R. (1999)
    2. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)1, 2 Nagaraja G.M. and Kandpal R.P. (2004)
    3. Protein profile of tax-associated complexes. (PubMed id 14530271)1, 2 Wu K.... Kashanchi F. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. (PubMed id 10920205)1, 2 Ling L. and Goeddel D.V. (2000)
    8. Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit. (PubMed id 16999686)1, 9 Ulrich M....Enz R. (2007)
    9. NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. (PubMed id 19609363)1, 9 Journo C....Weil R. (2009)
    10. Expression of the NF-kB inhibitor A20 is altered in th e Cystic fibrosis epithelium. (PubMed id 23018911)1 Kelly C....Schock B.C. (2012)

    External Searches for TAX1BP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TAX1BP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8887 HGNC: 11575 AceView: TAX1BP1 Ensembl:ENSG00000106052 euGenes: HUgn8887
    ECgene: TAX1BP1 H-InvDB: TAX1BP1

    Other Databases showing TAX1BP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAX1BP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAX1BP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAX1BP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TAX1BP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TAX1BP1 gene:
    Search GeneIP for patents involving TAX1BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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