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Aliases for TATDN3 Gene

Aliases for TATDN3 Gene

  • TatD DNase Domain Containing 3 2 3
  • EC 3.1.21.- 4
  • EC 3.1.21 63

External Ids for TATDN3 Gene

Previous GeneCards Identifiers for TATDN3 Gene

  • GC01P209354
  • GC01P211031
  • GC01P212965
  • GC01P183641

Summaries for TATDN3 Gene

GeneCards Summary for TATDN3 Gene

TATDN3 (TatD DNase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5-phosphomonoesters.

UniProtKB/Swiss-Prot for TATDN3 Gene

  • Putative deoxyribonuclease

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN3 Gene

Genomics for TATDN3 Gene

Regulatory Elements for TATDN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TATDN3 Gene

212,791,828 bp from pter
212,816,825 bp from pter
24,998 bases
Plus strand

Genomic View for TATDN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TATDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN3 Gene

Proteins for TATDN3 Gene

  • Protein details for TATDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative deoxyribonuclease TATDN3
    Protein Accession:
    Secondary Accessions:
    • A6NGS3
    • B7Z1C1
    • B7Z978
    • B7ZLQ6
    • E9PJE5
    • E9PNH3
    • G3V151
    • Q4G0L1

    Protein attributes for TATDN3 Gene

    274 amino acids
    Molecular mass:
    30333 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=AAH48115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TATDN3 Gene

    Alternative splice isoforms for TATDN3 Gene


neXtProt entry for TATDN3 Gene

Proteomics data for TATDN3 Gene at MOPED

Selected DME Specific Peptides for TATDN3 Gene

Post-translational modifications for TATDN3 Gene

  • Ubiquitination at Lys123
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for TATDN3 Gene

Protein Domains for TATDN3 Gene


Suggested Antigen Peptide Sequences for TATDN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TatD DNase family.
  • Belongs to the TatD DNase family.
genes like me logo Genes that share domains with TATDN3: view

No data available for Gene Families for TATDN3 Gene

Function for TATDN3 Gene

Molecular function for TATDN3 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease

Enzyme Numbers (IUBMB) for TATDN3 Gene

Gene Ontology (GO) - Molecular Function for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004536 deoxyribonuclease activity IBA --
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TATDN3: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TATDN3 Gene

Localization for TATDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN3 Gene

Subcellular locations from

Jensen Localization Image for TATDN3 Gene COMPARTMENTS Subcellular localization image for TATDN3 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0043229 intracellular organelle IBA --
genes like me logo Genes that share ontologies with TATDN3: view

Pathways for TATDN3 Gene

SuperPathways for TATDN3 Gene

No Data Available

Interacting Proteins for TATDN3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000431376 for TATDN3 Gene via STRING

Gene Ontology (GO) - Biological Process for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006308 DNA catabolic process IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN3: view

No data available for Pathways by source for TATDN3 Gene

Transcripts for TATDN3 Gene

Unigene Clusters for TATDN3 Gene

TatD DNase domain containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TATDN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN3 Gene

No ASD Table

Relevant External Links for TATDN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TATDN3 Gene

mRNA expression in normal human tissues for TATDN3 Gene

Protein differential expression in normal tissues for TATDN3 Gene

This gene is overexpressed in Heart (27.5) and Cervix (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TATDN3 Gene

SOURCE GeneReport for Unigene cluster for TATDN3 Gene Hs.530538

genes like me logo Genes that share expressions with TATDN3: view

Expression partners for TATDN3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TATDN3 Gene

Orthologs for TATDN3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TATDN3 35
  • 90.96 (n)
  • 91.58 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TATDN3 35
  • 91.12 (n)
  • 91.24 (a)
  • 91 (a)
(Mus musculus)
Mammalia Tatdn3 35
  • 85.19 (n)
  • 85.93 (a)
Tatdn3 16
Tatdn3 36
  • 79 (a)
(Pan troglodytes)
Mammalia TATDN3 35
  • 99.64 (n)
  • 99.64 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tatdn3 35
  • 85.68 (n)
  • 88.15 (a)
(Monodelphis domestica)
Mammalia TATDN3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TATDN3 36
  • 80 (a)
(Gallus gallus)
Aves TATDN3 35
  • 73.73 (n)
  • 75.46 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia TATDN3 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn3 35
  • 70.16 (n)
  • 75.28 (a)
(Danio rerio)
Actinopterygii LOC571912 35
  • 67.05 (n)
  • 69.32 (a)
  • 67 (a)
(Caenorhabditis elegans)
Secernentea B0432.8 35
  • 48.69 (n)
  • 40.55 (a)
B0432.8 36
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03500 35
  • 45.34 (n)
  • 31.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for TATDN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN3 Gene

Gene Tree for TATDN3 (if available)
Gene Tree for TATDN3 (if available)

Paralogs for TATDN3 Gene

No data available for Paralogs for TATDN3 Gene

Variants for TATDN3 Gene

Sequence variations from dbSNP and Humsavar for TATDN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1032961 -- 212,806,368(+) TCTCt(C/T)ttttt intron-variant
rs1032962 -- 212,806,608(+) CTGAG(C/T)TCGCT intron-variant
rs1032963 -- 212,806,642(+) TCCCA(A/G)AGTGC intron-variant
rs1054733 -- 212,816,498(+) AAAAT(C/T)GTATA utr-variant-3-prime
rs1133462 -- 212,816,549(+) TTAAT(C/T)TTGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TATDN3 Gene

Variant ID Type Subtype PubMed ID
dgv179e1 CNV Complex 17122850

Relevant External Links for TATDN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN3 Gene

Disorders for TATDN3 Gene

Relevant External Links for TATDN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TATDN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TATDN3 Gene

Publications for TATDN3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for TATDN3 Gene

Sources for TATDN3 Gene

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