TATDN3 Gene
protein-coding GIFtS: 46
GCID: GC01P212965
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TatD DNase domain containing 3
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Aliases for TATDN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| TatD DNase Domain Containing 31 2 | | Putative Deoxyribonuclease TATDN32 | | EC 3.1.21.-3 | | EC 3.1.218 |
Export aliases for TATDN3 gene to outside databasesPrevious GC identifers: GC01P209354 GC01P211031 GC01P183641 |
Summaries for TATDN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TATD3_HUMAN, Q17R31Function: Putative deoxyribonuclease
|
Genomic Views for TATDN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TATDN3 gene promoter: AML1a FOXO3 XBP-1 FOXO3b RORalpha1 POU2F1 POU2F1a FOXO4 Cart-1 FOXO3a Other transcription factors
Search SABiosciences Chromatin IP Primers for TATDN3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TATDN3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q32.3TATDN3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P212965: view genomic region
(about GC identifiers)
Start:
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212,965,170 bp from pter |
End:
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212,990,167 bp from pter |
Size:
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24,998 bases |
Orientation:
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plus strand |
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Proteins for TATDN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TATD3_HUMAN, Q17R31 (See
protein sequence)Recommended Name: Putative deoxyribonuclease TATDN3 Size: 274 amino acids; 30333 Da
Cofactor: Binds 2 divalent metal cations per subunit
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH48115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for TATDN3:2Y1H (3D)
 
Secondary accessions: A6NGS3 B7Z1C1 B7Z978 B7ZLQ6 E9PJE5 E9PNH3 G3V151 Q4G0L1Alternative splicing: 5 isoforms: Q17R31-1 Q17R31-2 Q17R31-3 Q17R31-4 Q17R31-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TATDN3: NX_Q17R31
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q17R31 2 DME Specific Peptides for TATDN3 (Q17R31)
TATDN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001036017.1 NP_001036018.1 NP_001139641.1 NP_001139642.1 NP_001139643.1 ENSEMBL proteins: ENSP00000431376 ENSP00000355941 ENSP00000432730 ENSP00000434801 ENSP00000433755 ENSP00000355940 ENSP00000436364 ENSP00000434428 ENSP00000431379 ENSP00000433143 ENSP00000434276 ENSP00000432006 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TATDN3 for ontologies About GeneDecksing
TATDN3 Antibody Products: Assay Products for TATDN3: |
Protein
Domains / Families for TATDN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TATDN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q17R31ProtoNet protein and cluster: Q17R31 1 Blocks protein family: IPB001130 TatD-related deoxyribonuclease
UniProtKB/Swiss-Prot: TATD3_HUMAN, Q17R31Similarity: Belongs to the TatD DNase family |
Function for TATDN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TATD3_HUMAN, Q17R31Function: Putative deoxyribonucleaseEnzyme Numbers (IUBMB): EC 3.1.212 EC 3.1.21.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN3 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN3 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): TATDN3 (NM_001042553) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TATDN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
TATDN3 for ontologies About GeneDecksing
|
Pathways & Interactions for TATDN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TATDN3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
 5/21 Interacting proteins for TATDN3 (ENSP000003559414) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
|
Drugs & Compounds for TATDN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TATDN3 Search CenterWatch for drugs/clinical trials and news about TATDN3 / TATD3 
|
Transcripts for TATDN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TATDN3 gene (5 alternative transcripts): NM_001042552.2 NM_001042553.2 NM_001146169.1 NM_001146170.1 NM_001146171.1 Unigene Cluster for TATDN3: TatD DNase domain containing 3 Hs.530538 [show with all ESTs]Unigene Representative Sequence: NM_00114617116 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532324 ENST00000366974(uc001hjo.2 uc010ptj.1 uc010ptk.1 uc001hjp.2 uc010ptl.1 uc010ptm.1) ENST00000530441 ENST00000526641 ENST00000531963 ENST00000366973 ENST00000526997 ENST00000533650 ENST00000532433 ENST00000488246 ENST00000525574 ENST00000497768 ENST00000530399 ENST00000525569 ENST00000530392 ENST00000527693
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN3 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN3 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): TATDN3 (NM_001042553) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TATDN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN3  |
Additional cDNA sequence: AK293129.1 AK295335.1 AK304557.1 AL832248.1 BC048115.1 BC113638.1 BC117485.1 BC143956.1 BC143957.1 7 DOTS entries: DT.452530 DT.100739606 DT.75133493 DT.95362685 DT.100742801 DT.99984295 DT.302776 24/75 AceView cDNA sequences (see all 75): BE501397 AL526258 BM989374 CA433356 AW611562 BM271845 CR619489 AV710525 AI655590 AL562488 BG777155 BI667889 BI545444 BF796613 BX387124 BF791509 BC048115 AA812080 BM907308 BI334853 AI274071 AA906896 BE241708 AL832248 GeneLoc Exon Structure
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Expression for TATDN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TATDN3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GAAGGAGTAA
About this image See TATDN3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TATDN3
SOURCE GeneReport for Unigene cluster: Hs.530538 SABiosciences Custom PCR Arrays for TATDN3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TATDN3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TATDN3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TATDN3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TATDN3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN3 |
Orthologs for TATDN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TATDN3 gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for TATDN3 (if available) TreeFam Gene Tree for TATDN3 (if available)  |
Paralogs for TATDN3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TATDN3 gene
- TATDN12
1 SIMAP similar gene for TATDN3 using alignment to 8 protein entries: TATD3_HUMAN (see all proteins):TATDN1
TATDN3 for paralogs About GeneDecksing
|
Genomic Variants for TATDN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TATDN3 (212965170 - 212990167 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TATDN3 1 CNV: 2347  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TATDN3 |
|
Disorders
/ Diseases for TATDN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TATDN3 for disorders About GeneDecksing
5 diseases for TATDN3: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma pneumonia tuberculosis mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: TATDN3 (1 document) Export disorders for TATDN3 gene to outside databases
|
Publications for TATDN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TATDN3 gene integrated from 9 sources: (articles sorted by number of sources associating them with TATDN3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- NotI flanking sequences: a tool for gene discovery and verification of the human genome. (PubMed id 12136098)1 Kutsenko A.S....Zabarovsky E.R. (2002)
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External Searches for TATDN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing TATDN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TATDN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TATDN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TATDN3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TATDN3 gene: Search GeneIP for patents involving TATDN3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TATDN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for TATDN3 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TATDN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TATDN3 | | OriGene Protein Over-expression Lysate for TATDN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TATDN3 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN3 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for TATDN3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for TATDN3 | | OriGene Custom Protein Services for TATDN3 | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TATDN3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TATDN3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TATDN3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TATDN3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TATDN3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TATDN3 |
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 |  |  |  | |
| | | Search Tocris compounds for TATDN3 |
| |  |  |  |  | | | | | Recombinant Protein for TATDN3 |
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 | | TATDN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN3 |
|  |  |  | | | ThermoFisher Antibodies for TATDN3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN3 |
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