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Aliases for TATDN2 Gene

Aliases for TATDN2 Gene

  • TatD DNase Domain Containing 2 2 3 5
  • EC 3.1.21.- 4
  • KIAA0218 4

External Ids for TATDN2 Gene

Previous GeneCards Identifiers for TATDN2 Gene

  • GC03P010266
  • GC03P010267
  • GC03P010225
  • GC03P010289

Summaries for TATDN2 Gene

GeneCards Summary for TATDN2 Gene

TATDN2 (TatD DNase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is TATDN1.

UniProtKB/Swiss-Prot for TATDN2 Gene

  • Putative deoxyribonuclease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN2 Gene

Genomics for TATDN2 Gene

Regulatory Elements for TATDN2 Gene

Enhancers for TATDN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TATDN2 on UCSC Golden Path with GeneCards custom track

Promoters for TATDN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TATDN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TATDN2 Gene

10,248,023 bp from pter
10,281,222 bp from pter
33,200 bases
Plus strand

Genomic View for TATDN2 Gene

Genes around TATDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN2 Gene

Proteins for TATDN2 Gene

  • Protein details for TATDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative deoxyribonuclease TATDN2
    Protein Accession:
    Secondary Accessions:
    • Q3MIL9
    • Q5BKU0

    Protein attributes for TATDN2 Gene

    761 amino acids
    Molecular mass:
    85023 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    • Sequence=BAA13208.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TATDN2 Gene

Proteomics data for TATDN2 Gene at MOPED

Post-translational modifications for TATDN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TATDN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TATDN2 Gene

Domains & Families for TATDN2 Gene

Protein Domains for TATDN2 Gene

Suggested Antigen Peptide Sequences for TATDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TatD-type hydrolase family.
  • Belongs to the TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN2: view

No data available for Gene Families for TATDN2 Gene

Function for TATDN2 Gene

Molecular function for TATDN2 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN2 Gene

genes like me logo Genes that share phenotypes with TATDN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TATDN2 Gene

Localization for TATDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN2 Gene

Subcellular locations from

Jensen Localization Image for TATDN2 Gene COMPARTMENTS Subcellular localization image for TATDN2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TATDN2: view

Pathways & Interactions for TATDN2 Gene

genes like me logo Genes that share pathways with TATDN2: view

Interacting Proteins for TATDN2 Gene

Gene Ontology (GO) - Biological Process for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0006308 DNA catabolic process IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN2: view

No data available for SIGNOR curated interactions for TATDN2 Gene

Drugs & Compounds for TATDN2 Gene

No Compound Related Data Available

Transcripts for TATDN2 Gene

Unigene Clusters for TATDN2 Gene

TatD DNase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3: -

Relevant External Links for TATDN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TATDN2 Gene

mRNA expression in normal human tissues for TATDN2 Gene

Protein differential expression in normal tissues from HIPED for TATDN2 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TATDN2 Gene

SOURCE GeneReport for Unigene cluster for TATDN2 Gene Hs.475401

genes like me logo Genes that share expression patterns with TATDN2: view

Protein tissue co-expression partners for TATDN2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TATDN2 Gene

Orthologs for TATDN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TATDN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TATDN2 35
  • 81.84 (n)
  • 78.8 (a)
-- 36
  • 78 (a)
(Canis familiaris)
Mammalia TATDN2 35
  • 87.29 (n)
  • 85.37 (a)
-- 36
  • 84 (a)
(Mus musculus)
Mammalia Tatdn2 35
  • 77.08 (n)
  • 73.61 (a)
Tatdn2 16
Tatdn2 36
  • 70 (a)
(Pan troglodytes)
Mammalia TATDN2 35
  • 99.34 (n)
  • 98.82 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tatdn2 35
  • 78.03 (n)
  • 73.84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn2 35
  • 59.27 (n)
  • 52.68 (a)
(Danio rerio)
Actinopterygii tatdn2 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3308 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea Y24F12A.1 36
  • 27 (a)
Y37H2A.1 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 15 (a)
Species with no ortholog for TATDN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN2 Gene

Gene Tree for TATDN2 (if available)
Gene Tree for TATDN2 (if available)

Paralogs for TATDN2 Gene

Paralogs for TATDN2 Gene Pseudogenes for TATDN2 Gene

genes like me logo Genes that share paralogs with TATDN2: view

Variants for TATDN2 Gene

Sequence variations from dbSNP and Humsavar for TATDN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2241314 - 10,260,372(+) AGAGC(A/C/G)TCCCA reference, missense
rs394558 - 10,260,488(+) CAGAG(A/G)TCAGC reference, missense
rs2075352 - 10,270,255(+) CGTTC(C/T)GGAGC reference, missense
rs151759 -- 10,272,918(+) cctgg(C/G)gtccc intron-variant
rs151760 -- 10,272,541(+) tcaag(C/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN2 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
nsv876526 CNV Loss 21882294
nsv460420 CNV Loss 19166990
nsv236904 CNV Loss 16902084
nsv508903 CNV Insertion 20534489

Variation tolerance for TATDN2 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TATDN2 Gene

Disorders for TATDN2 Gene

Relevant External Links for TATDN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TATDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TATDN2 Gene

Publications for TATDN2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for TATDN2 Gene

Sources for TATDN2 Gene