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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TATDN2 Gene

protein-coding   GIFtS: 52
GCID: GC03P010289

TatD DNase Domain Containing 2

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TatD DNase Domain Containing 21 2
Putative Deoxyribonuclease TATDN22
EC 3.1.21.-3
KIAA02183

External Ids:    HGNC: 289881   Entrez Gene: 97972   Ensembl: ENSG000001570147   UniProtKB: Q930753   
ORGUL members:         
NONCODE14:n342487      

Export aliases for TATDN2 gene to outside databases

Previous GC identifers: GC03P010266 GC03P010267 GC03P010225


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TATDN2 Gene: 
TATDN2 (TatD DNase domain containing 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TATDN2 include pneumonia, and among its related super-pathways are Activation of Chaperones by IRE1alpha and Post-translational protein modification. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters and metal ion binding. An important paralog of this gene is ENSG00000272410.

UniProtKB/Swiss-Prot: TATD2_HUMAN, Q93075
Function: Putative deoxyribonuclease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TATDN2 gene promoter:
         TBP   AML1a   Nkx2-2   SREBP-1c   Pax-2   Pax-2a   SREBP-1b   SREBP-1a   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTATDN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TATDN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TATDN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

TATDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TATDN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P010289:  view genomic region     (about GC identifiers)

Start:
10,289,707 bp from pter      End:
10,322,906 bp from pter
Size:
33,200 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TATD2_HUMAN, Q93075 (See protein sequence)
Recommended Name: Putative deoxyribonuclease TATDN2  
Size: 761 amino acids; 85023 Da
Cofactor: Binds 2 divalent metal cations per subunit (By similarity)
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA13208.2; Type=Erroneous initiation;
Secondary accessions: Q3MIL9 Q5BKU0

Explore the universe of human proteins at neXtProt for TATDN2: NX_Q93075

Explore proteomics data for TATDN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q93075

  • TATDN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TATDN2 Protein Expression
    REFSEQ proteins: NP_055575.3  
    ENSEMBL proteins: 
     ENSP00000287652   ENSP00000408736   ENSP00000389896  
    Reactome Protein details: Q93075
    Human Recombinant Protein Products for TATDN2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TATDN2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    TATDN2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR018228 DNase_TatD-rel_CS
     IPR001130 TatD_family

    Graphical View of Domain Structure for InterPro Entry Q93075

    ProtoNet protein and cluster: Q93075

    1 Blocks protein domain: IPB001130 TatD-related deoxyribonuclease

    UniProtKB/Swiss-Prot: TATD2_HUMAN, Q93075
    Similarity: Belongs to the TatD DNase family


    TATDN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TATD2_HUMAN, Q93075
    Function: Putative deoxyribonuclease (By similarity)

         Enzyme Number (IUBMB): EC 3.1.21.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA--
    GO:0046872metal ion binding IEA--
         
    TATDN2 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TATDN2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TATDN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for TATDN2
        Activation of Chaperone Genes by XBP1(S)
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response



    TATDN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TATDN2

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    TATDN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TATDN2 (TATD2)

    Search CenterWatch for drugs/clinical trials and news about TATDN2 / TATD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TATDN2 gene: 
    NM_014760.3  

    Unigene Cluster for TATDN2:

    TatD DNase domain containing 2
    Hs.475401  [show with all ESTs]
    Unigene Representative Sequence: NM_014760
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287652(uc003bvg.2 uc003bvf.3 uc011atr.2) ENST00000448281(uc011ats.1 uc011att.1)
    ENST00000426850 ENST00000496355
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TATDN2 (see all 10):
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK289794.1 AK311203.1 BC090935.1 BC101770.1 BC101776.1 D86972.1 EU789548.1 EU789550.1 
    EU789551.1 

    6 DOTS entries:

    DT.95181644  DT.451740  DT.97776641  DT.95269214  DT.120926052  DT.75145271 

    24/221 AceView cDNA sequences (see all 221):

    CR605569 BQ929434 AW007439 CA444949 BQ215383 BX478389 BM693787 AW589942 
    AI627779 BE348742 CD673243 AA776446 AI274439 BM980520 AI742189 CK820257 
    CB109110 BE856484 AI362921 BQ009489 BU169782 AI373613 BM142336 BQ055443 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TATDN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                                        -           -               
    SP2:                                                        -                           
    SP3:                                                                    -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for TATDN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TATDN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTCTCCA
    TATDN2 Expression
    About this image


    See TATDN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TATDN2

    SOURCE GeneReport for Unigene cluster: Hs.475401
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TATDN2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tatdn21 , 5 TatD DNase domain containing 21, 5 77.59(n)1
    74.03(a)1
      6 (52.83 cM)5
    3818011  NM_001033463.31  NP_001028635.21 
     1136970505 
    lizard
    (Anolis carolinensis)
    Reptilia TATDN26
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL343273.1(872079-882898)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480587012   -- 77.9(n)    48058701 
    zebrafish
    (Danio rerio)
    Actinopterygii AW154092.12   -- 70.75(n)    AW154092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33086
    --
    22(a)
    1 ↔ 1
    3R(17096800-17099537)
    worm
    (Caenorhabditis elegans)
    Secernentea Y24F12A.16
    Y37H2A.16
    (see all 3)
    Protein Y37H2A.1, isoform a
    (see all 3)
    28(a)
    25(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    IV(11605308-11607523)
    V(18108270-18114757)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YBL055C6
    3'-->5' exonuclease and endonuclease with a possib...
    13(a)
    1 → many
    II(115573-116829)


    ENSEMBL Gene Tree for TATDN2 (if available)
    TreeFam Gene Tree for TATDN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TATDN2 gene
    ENSG000002724102  TATDN12  

    TATDN2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TATDN2
    PGOHUM00000248529 PGOHUM00000243432 PGOHUM00000241726


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/810 SNPs in TATDN2 are shown (see all 810)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3710461,2
    C,F,A,H--10288188(+) TTATCC/TTGCtt 1 -- us2k19Minor allele frequency- T:0.32NA WA CSA EA 372
    rs1123205781,2
    C,F--10288284(+) CCCGGA/GTTCAC 1 -- us2k10--------
    rs1391677491,2
    --10288489(+) CCACCA/GCACCC 1 -- us2k10--------
    rs353719691,2
    C--10288586(+) ATTAA-/TTTTTT 1 -- us2k10--------
    rs1869254661,2
    --10288636(+) GTGGCA/GCAATC 1 -- us2k10--------
    rs1499294371,2
    --10288720(+) CAGGCA/GCCTGC 1 -- us2k10--------
    rs11800471,2
    --10288750(-) taaaaA/Ctacaa 1 -- us2k10--------
    rs25434591,2
    C,A,H--10288774(-) aatacT/Ggtgaa 1 -- us2k12Minor allele frequency- G:0.25NA 4
    rs26194971,2
    C,F--10288777(+) accgtA/G/Tttagc 1 -- us2k16NA WA 12
    rs1850512191,2
    C--10288795(+) GTCTCA/C/GATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TATDN2 (10289707 - 10322906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TATDN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv809e201CNV Deletion23290073
    nsv436362CNV Deletion17901297
    nsv508903CNV Insertion20534489
    nsv436869CNV Insertion17901297
    nsv460420CNV Loss19166990
    nsv876526CNV Loss21882294
    nsv236904CNV Loss16902084
    esv4117CNV Complex18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TATDN2:    About MalaCards
    pneumonia    


    TATDN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TATDN2
    Human Genome Epidemiology (HuGE) Navigator: TATDN2 (2 documents)

    Export disorders for TATDN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TATDN2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TATDN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
    2. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    4. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    7. Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene. (PubMed id 18954468)1 Seim I.... Chopin L.K. (2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9797 HGNC: 28988 AceView: TATDN2 Ensembl:ENSG00000157014 euGenes: HUgn9797
    ECgene: TATDN2 H-InvDB: TATDN2

    (According to HUGE)
    About This Section
    HUGE: KIAA0218

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TATDN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TATDN2 gene:
    Search GeneIP for patents involving TATDN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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