Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TATDN2 Gene

protein-coding   GIFtS: 52
GCID: GC03P010289

TatD DNase Domain Containing 2

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TatD DNase Domain Containing 21 2
Putative Deoxyribonuclease TATDN22
EC 3.1.21.-3
KIAA02183

External Ids:    HGNC: 289881   Entrez Gene: 97972   Ensembl: ENSG000001570147   UniProtKB: Q930753   

Export aliases for TATDN2 gene to outside databases

Previous GC identifers: GC03P010266 GC03P010267 GC03P010225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TATDN2 Gene:
TATDN2 (TatD DNase domain containing 2) is a protein-coding gene. Diseases associated with TATDN2 include pneumonia. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters. An important paralog of this gene is ENSG00000272410.

UniProtKB/Swiss-Prot: TATD2_HUMAN, Q93075
Function: Putative deoxyribonuclease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TATDN2 gene promoter:
         TBP   AML1a   Nkx2-2   SREBP-1c   Pax-2   Pax-2a   SREBP-1b   SREBP-1a   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTATDN2 promoter sequence
   Search Chromatin IP Primers for TATDN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TATDN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

TATDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TATDN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P010289:  view genomic region     (about GC identifiers)

Start:
10,289,707 bp from pter      End:
10,322,906 bp from pter
Size:
33,200 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TATD2_HUMAN, Q93075 (See protein sequence)
Recommended Name: Putative deoxyribonuclease TATDN2  
Size: 761 amino acids; 85023 Da
Cofactor: Binds 2 divalent metal cations per subunit (By similarity)
Sequence caution: Sequence=BAA13208.2; Type=Erroneous initiation;
Secondary accessions: Q3MIL9 Q5BKU0

Explore the universe of human proteins at neXtProt for TATDN2: NX_Q93075

Explore proteomics data for TATDN2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TATDN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055575.3  
    ENSEMBL proteins: 
     ENSP00000287652   ENSP00000408736   ENSP00000389896  
    Reactome Protein details: Q93075

    TATDN2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TATDN2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TATDN2
    GenScript Custom Purified and Recombinant Proteins Services for TATDN2
    Novus Biologicals TATDN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TATDN2

    TATDN2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TATDN2
    Novus Biologicals TATDN2 Antibody
    Abcam antibodies for TATDN2
    Cloud-Clone Corp. Antibodies for TATDN2
    ThermoFisher Antibody for TATDN2
    Search LSBio for Antibodies for TATDN2

    TATDN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TATDN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TATDN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TATDN2
    Cloud-Clone Corp. CLIAs for TATDN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR018228 DNase_TatD-rel_CS
     IPR001130 TatD_family

    Graphical View of Domain Structure for InterPro Entry Q93075

    ProtoNet protein and cluster: Q93075

    1 Blocks protein domain: IPB001130 TatD-related deoxyribonuclease

    UniProtKB/Swiss-Prot: TATD2_HUMAN, Q93075
    Similarity: Belongs to the TatD DNase family


    TATDN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TATD2_HUMAN, Q93075
    Function: Putative deoxyribonuclease (By similarity)

         Enzyme Number (IUBMB): EC 3.1.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA--
    GO:0046872metal ion binding IEA--
         
    TATDN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TATDN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TATDN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TATDN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TATDN2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TATDN2:
    hsa-mir-615-3p (MIRT040413), hsa-mir-222-3p (MIRT046738), hsa-mir-423-3p (MIRT016680), hsa-mir-34a-5p (MIRT025466)

    Block miRNA regulation of human, mouse, rat TATDN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TATDN2 (see all 10):
    hsa-miR-4254 hsa-miR-29c hsa-miR-29a hsa-miR-3926 hsa-miR-214 hsa-miR-124 hsa-miR-506 hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidTATDN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TATDN2
    Predesigned siRNA for gene silencing in human, mouse, rat TATDN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TATDN2

    Clone
    Products:
         
    OriGene clones in human, mouse for TATDN2 (see all 6)
    OriGene ORF clones in mouse, rat for TATDN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TATDN2 (NM_014760)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TATDN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TATDN2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TATDN2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TATD2_HUMAN, Q93075: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    TATDN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TATDN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TATDN2
        XBP1(S) activates chaperone genes



    TATDN2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TATDN2
    Interactions:

        Search GeneGlobe Interaction Network for TATDN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TATDN2 (ENSP000002876524) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2V1ENSP000003403054STRING: ENSP00000340305
    CDC16ENSP000003485544STRING: ENSP00000348554
    TMEM189-UBE2V1ENSP000003441664STRING: ENSP00000344166
    C1DENSP000003481074STRING: ENSP00000348107
    EXOSC9ENSP000003689844STRING: ENSP00000368984
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    TATDN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TATDN2 (TATD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TATDN2 gene: 
    NM_014760.3  

    Unigene Cluster for TATDN2:

    TatD DNase domain containing 2
    Hs.475401  [show with all ESTs]
    Unigene Representative Sequence: NM_014760
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287652(uc003bvg.2 uc003bvf.3 uc011atr.2) ENST00000448281(uc011ats.1 uc011att.1)
    ENST00000426850 ENST00000496355
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TATDN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TATDN2 (see all 10):
    hsa-miR-4254 hsa-miR-29c hsa-miR-29a hsa-miR-3926 hsa-miR-214 hsa-miR-124 hsa-miR-506 hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidTATDN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TATDN2
    Predesigned siRNA for gene silencing in human, mouse, rat TATDN2
    Clone
    Products:
         
    OriGene clones in human, mouse for TATDN2 (see all 6)
    OriGene ORF clones in mouse, rat for TATDN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TATDN2 (NM_014760)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TATDN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TATDN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TATDN2
      QuantiTect SYBR Green Assays in human, mouse, rat TATDN2
      QuantiFast Probe-based Assays in human, mouse, rat TATDN2

    Additional mRNA sequence: 

    AK289794.1 AK311203.1 BC090935.1 BC101770.1 BC101776.1 D86972.1 EU789548.1 EU789550.1 
    EU789551.1 

    6 DOTS entries:

    DT.95181644  DT.451740  DT.97776641  DT.95269214  DT.120926052  DT.75145271 

    Selected AceView cDNA sequences (see all 221):

    BM800027 BM666323 BF478230 AI830887 BU169782 BU501467 AW007439 BQ007720 
    AW083624 CA444949 AW589942 BQ929434 CR620522 BE856484 BM693787 BU738225 
    CK820257 AL559510 CD673243 AI362921 BQ009489 AI373613 AA776446 AI742189 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TATDN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                                        -           -               
    SP2:                                                        -                           
    SP3:                                                                    -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for TATDN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TATDN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTCTCCA
    TATDN2 Expression
    About this image

    TATDN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TATDN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475401
        Custom PCR Arrays for TATDN2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TATDN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TATDN2
    QuantiTect SYBR Green Assays in human, mouse, rat TATDN2
    QuantiFast Probe-based Assays in human, mouse, rat TATDN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TATDN2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tatdn21 , 5 TatD DNase domain containing 21, 5 77.08(n)1
    73.61(a)1
      6 (52.83 cM)5
    3818011  NM_001033463.31  NP_001028635.21 
     1136970505 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    GL343273.1(872079-882898)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480587012   -- 77.9(n)    48058701 
    zebrafish
    (Danio rerio)
    Actinopterygii AW154092.12   -- 70.75(n)    AW154092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33086
    --
    22(a)
    1 → many
    3R(17096800-17099537)
    worm
    (Caenorhabditis elegans)
    Secernentea Y24F12A.16
    Y37H2A.16
    Protein Y37H2A.1, isoform a
    27(a)
    26(a)
    many ↔ many
    many ↔ many
    IV(11605308-11607523) WBGene00012496
    V(18108270-18114757) WBGene00012562
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    3'-->5' exonuclease and endonuclease with a possib...
    15(a)
    1 → many
    II(115573-116829) YBL055C


    ENSEMBL Gene Tree for TATDN2 (if available)
    TreeFam Gene Tree for TATDN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TATDN2 gene
    ENSG000002724102  TATDN12  

    TATDN2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TATDN2
    PGOHUM00000248529 PGOHUM00000243432 PGOHUM00000241726


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TATDN2 (see all 810)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3710461,2
    C,F,A,H--10288188(+) TTATCC/TTGCtt 1 -- us2k19Minor allele frequency- T:0.32NA WA CSA EA 372
    rs1123205781,2
    C,F--10288284(+) CCCGGA/GTTCAC 1 -- us2k10--------
    rs1391677491,2
    --10288489(+) CCACCA/GCACCC 1 -- us2k10--------
    rs353719691,2
    C--10288586(+) ATTAA-/TTTTTT 1 -- us2k10--------
    rs1869254661,2
    --10288636(+) GTGGCA/GCAATC 1 -- us2k10--------
    rs1499294371,2
    --10288720(+) CAGGCA/GCCTGC 1 -- us2k10--------
    rs11800471,2
    --10288750(-) taaaaA/Ctacaa 1 -- us2k10--------
    rs25434591,2
    C,A,H--10288774(-) aatacT/Ggtgaa 1 -- us2k12Minor allele frequency- G:0.25NA 4
    rs26194971,2
    C,F--10288777(+) accgtA/G/Tttagc 1 -- us2k16NA WA 12
    rs1850512191,2
    C--10288795(+) GTCTCA/C/GATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TATDN2 (10289707 - 10322906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TATDN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv809e201CNV Deletion23290073
    nsv436362CNV Deletion17901297
    nsv508903CNV Insertion20534489
    nsv436869CNV Insertion17901297
    nsv460420CNV Loss19166990
    nsv876526CNV Loss21882294
    nsv236904CNV Loss16902084
    esv4117CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TATDN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TATDN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for TATDN2:    
    About MalaCards
    pneumonia


    TATDN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TATDN2
    Human Genome Epidemiology (HuGE) Navigator: TATDN2 (2 documents)

    Export disorders for TATDN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TATDN2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TATDN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    4. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    6. Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene. (PubMed id 18954468)1 Seim I.... Chopin L.K. (BMC Mol. Biol. 2008)
    7. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9797 HGNC: 28988 AceView: TATDN2 Ensembl:ENSG00000157014 euGenes: HUgn9797
    ECgene: TATDN2 H-InvDB: TATDN2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0218

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TATDN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TATDN2 gene:
    Search GeneIP for patents involving TATDN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TATDN2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TATDN2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TATDN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TATDN2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TATDN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TATDN2   OriGene Custom Protein Services for TATDN2  

     
     
     Block miRNA regulation of human, mouse, rat TATDN2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TATDN2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TATDN2 Predesigned siRNA for gene silencing in human, mouse, rat TATDN2
     QuantiFast Probe-based Assays in human, mouse, rat TATDN2 QuantiTect SYBR Green Assays in human, mouse, rat TATDN2
     Custom PCR Arrays for TATDN2 Search Chromatin IP Primers for TATDN2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TATDN2  Search GeneGlobe Interaction Network for TATDN2
     Regulatory tfbs in TATDN2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TATDN2 GenScript cDNA clones with any tag delivered in your preferred vector for TATDN2
     GenScript Custom Assay Services for TATDN2 GenScript Custom overexpressing Cell Line Services for TATDN2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TATDN2 (TATD2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TATDN2 antibodies
     TATDN2 lysates
     Antibodies for TATDN2
     See all of Abcam's Antibodies, Kits and Proteins for TATDN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TATDN2
     Antibodies for TATDN2
     ELISAs for TATDN2
     CLIAs for TATDN2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TATDN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN2
     SwitchGear 3'UTR luciferase reporter plasmids for TATDN2
     SwitchGear Promoter luciferase reporter plasmids for TATDN2
     ThermoFisher Antibody for TATDN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TATDN2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TATDN2
     Search LSBio for Antibodies for TATDN2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TATDN2 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4