Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TATDN2 Gene

Aliases for TATDN2 Gene

  • TatD DNase Domain Containing 2 2 3 5
  • EC 3.1.21.- 4
  • KIAA0218 4

External Ids for TATDN2 Gene

Previous GeneCards Identifiers for TATDN2 Gene

  • GC03P010266
  • GC03P010267
  • GC03P010225
  • GC03P010289

Summaries for TATDN2 Gene

GeneCards Summary for TATDN2 Gene

TATDN2 (TatD DNase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Unfolded Protein Response (UPR). GO annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is ENSG00000272410.

UniProtKB/Swiss-Prot for TATDN2 Gene

  • Putative deoxyribonuclease.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN2 Gene

Genomics for TATDN2 Gene

Regulatory Elements for TATDN2 Gene

Enhancers for TATDN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G010188 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -53.2 -53179 12.1 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 IRAK2 GHRLOS GHRL VHL TATDN2 FANCD2OS PRRT3 LINC00852 CAMK1 ARPC4
GH03G010201 2 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -43.5 -43502 6.7 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ZFP64 ARID4B SIN3A IRAK2 TATDN2 VHL GHRLOS ARPC4 FANCD2OS GHRL SEC13 CAMK1 TADA3
GH03G010185 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -61.1 -61069 2.5 HDAC1 PKNOX1 ZNF146 ZNF664 FOSL1 ZNF121 ZNF766 GATA2 ELK1 EED IRAK2 GHRLOS TATDN2 GHRL FANCD2OS LINC00852 VHL GC03M010202
GH03G009883 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -363.6 -363632 2.2 PKNOX1 ARNT TCF12 GTF3C2 ZNF766 GATA2 FOS ZNF263 JUNB SMARCB1 CIDEC IL17RC JAGN1 RAD18 EMC3-AS1 GHRLOS ENSG00000269982 FANCD2 TATDN2 LINC00852
GH03G009420 1.6 Ensembl ENCODE dbSUPER 10.4 -824.9 -824869 5.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SRGAP3 EMC3-AS1 ENSG00000269982 TATDN2 ENSG00000269886 THUMPD3-AS1 GC03M009409 GC03P009403
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TATDN2 on UCSC Golden Path with GeneCards custom track

Promoters for TATDN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000148378 707 2401 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for TATDN2 Gene

Chromosome:
3
Start:
10,248,023 bp from pter
End:
10,281,222 bp from pter
Size:
33,200 bases
Orientation:
Plus strand

Genomic View for TATDN2 Gene

Genes around TATDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN2 Gene

Proteins for TATDN2 Gene

  • Protein details for TATDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93075-TATD2_HUMAN
    Recommended name:
    Putative deoxyribonuclease TATDN2
    Protein Accession:
    Q93075
    Secondary Accessions:
    • Q3MIL9
    • Q5BKU0

    Protein attributes for TATDN2 Gene

    Size:
    761 amino acids
    Molecular mass:
    85023 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13208.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TATDN2 Gene

Post-translational modifications for TATDN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TATDN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TATDN2 Gene

Domains & Families for TATDN2 Gene

Protein Domains for TATDN2 Gene

Suggested Antigen Peptide Sequences for TATDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93075

UniProtKB/Swiss-Prot:

TATD2_HUMAN :
  • Belongs to the TatD-type hydrolase family.
Family:
  • Belongs to the TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN2: view

No data available for Gene Families for TATDN2 Gene

Function for TATDN2 Gene

Molecular function for TATDN2 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN2 Gene

Gene Ontology (GO) - Molecular Function for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004536 deoxyribonuclease activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TATDN2: view
genes like me logo Genes that share phenotypes with TATDN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TATDN2 Gene

Localization for TATDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TATDN2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with TATDN2: view

Pathways & Interactions for TATDN2 Gene

genes like me logo Genes that share pathways with TATDN2: view

Gene Ontology (GO) - Biological Process for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0006308 DNA catabolic process IBA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN2: view

No data available for SIGNOR curated interactions for TATDN2 Gene

Drugs & Compounds for TATDN2 Gene

No Compound Related Data Available

Transcripts for TATDN2 Gene

Unigene Clusters for TATDN2 Gene

TatD DNase domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for TATDN2 Gene

GeneLoc Exon Structure for
TATDN2
ECgene alternative splicing isoforms for
TATDN2

Expression for TATDN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TATDN2 Gene

Protein differential expression in normal tissues from HIPED for TATDN2 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TATDN2 Gene



Protein tissue co-expression partners for TATDN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TATDN2 Gene:

TATDN2

SOURCE GeneReport for Unigene cluster for TATDN2 Gene:

Hs.475401

Evidence on tissue expression from TISSUES for TATDN2 Gene

  • Nervous system(4.7)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with TATDN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TATDN2 Gene

Orthologs for TATDN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TATDN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TATDN2 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia TATDN2 34
  • 87.29 (n)
-- 35
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TATDN2 34
  • 81.84 (n)
-- 35
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tatdn2 34
  • 78.03 (n)
mouse
(Mus musculus)
Mammalia Tatdn2 34 16 35
  • 77.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn2 34
  • 59.27 (n)
zebrafish
(Danio rerio)
Actinopterygii tatdn2 35
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3308 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y24F12A.1 35
  • 27 (a)
ManyToMany
Y37H2A.1 35
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 15 (a)
OneToMany
Species where no ortholog for TATDN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN2 Gene

ENSEMBL:
Gene Tree for TATDN2 (if available)
TreeFam:
Gene Tree for TATDN2 (if available)

Paralogs for TATDN2 Gene

Paralogs for TATDN2 Gene

Pseudogenes.org Pseudogenes for TATDN2 Gene

genes like me logo Genes that share paralogs with TATDN2: view

Variants for TATDN2 Gene

Sequence variations from dbSNP and Humsavar for TATDN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000046008 -- 10,267,575(+) AAAAT(A/G)TTGTA intron-variant
rs1000081783 -- 10,266,601(+) GGGTC(A/G)GATGC intron-variant
rs1000161179 -- 10,248,758(+) CGCCC(A/G)GCCCC utr-variant-5-prime
rs1000222636 -- 10,273,438(+) GAATG(C/T)TTTAT intron-variant
rs1000334155 -- 10,254,023(+) TCTCT(C/G)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN2 Gene

Variant ID Type Subtype PubMed ID
dgv762e201 CNV deletion 23290073
esv4117 OTHER complex 18987735
nsv1073204 CNV deletion 25765185
nsv1121603 CNV deletion 24896259
nsv236904 CNV deletion 16902084
nsv436362 CNV deletion 17901297
nsv436869 CNV insertion 17901297
nsv460420 CNV loss 19166990
nsv508903 CNV insertion 20534489
nsv589650 CNV loss 21841781

Variation tolerance for TATDN2 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TATDN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TATDN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN2 Gene

Disorders for TATDN2 Gene

Relevant External Links for TATDN2

Genetic Association Database (GAD)
TATDN2
Human Genome Epidemiology (HuGE) Navigator
TATDN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TATDN2

No disorders were found for TATDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TATDN2 Gene

Publications for TATDN2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3 64
  5. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64

Products for TATDN2 Gene

Sources for TATDN2 Gene

Content
Loading form....