TATDN1 Gene
protein-coding GIFtS: 48
GCID: GC08M125500
|
|
TatD DNase domain containing 1
| |
Aliases
for TATDN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| TatD DNase Domain Containing 11 2 | | Hepatocarcinoma High Expression Protein2 3 | | CDA111 | | Putative Deoxyribonuclease TATDN12 | | EC 3.1.21.-3 | | EC 3.1.218 |
| External Ids: | HGNC: 242201 | Entrez Gene: 839402 | Ensembl: ENSG000001476877 | UniProtKB: Q6P1N93 | | ORGUL members: | |
|---|
| NONCODE:n407869 | |
Export aliases for TATDN1 gene to outside databasesPrevious GC identifers: GC08M125458 GC08M125569 GC08M120826
|---|
Summaries
for TATDN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TATD1_HUMAN, Q6P1N9Function: Putative deoxyribonuclease (By similarity)
|
Genomic Views
for TATDN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TATDN1 gene promoter:
TBP IRF-2 POU2F1 POU2F1a Lmo2 Nkx2-5 NF-kappaB1 NF-kappaB C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TATDN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TATDN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13TATDN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M125500: view genomic region
(about GC identifiers)
Start:
|
125,500,726 bp from pter |
End:
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125,551,699 bp from pter |
Size:
|
50,974 bases |
Orientation:
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minus strand |
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Proteins
for TATDN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TATD1_HUMAN, Q6P1N9 (See
protein sequence)Recommended Name: Putative deoxyribonuclease TATDN1 Size: 297 amino acids; 33602 Da
Cofactor: Binds 2 divalent metal cations per subunit (By similarity)
Subcellular location: Nucleus (Potential)
1 PDB 3D structure from  and Proteopedia  for TATDN1:2XIO (3D)
Secondary accessions: B2R5J0 Q8TD02 Q9BY40Alternative splicing: 2 isoforms: Q6P1N9-1 Q6P1N9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TATDN1: NX_Q6P1N9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P1N9
4/8 DME Specific Peptides for TATDN1 (Q6P1N9) (see all 8)
TATDN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001139632.1 NP_114415.1
ENSEMBL proteins: ENSP00000431052 ENSP00000276692 ENSP00000428609 ENSP00000428336 ENSP00000430274 ENSP00000430201 ENSP00000429831 ENSP00000429541 ENSP00000428580 ENSP00000430481 ENSP00000430756 ENSP00000428109 ENSP00000427807
Human Recombinant Protein Products for TATDN1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TATDN1 for ontologies About GeneDecksing
TATDN1 Antibody Products:
Assay Products for TATDN1: |
Protein
Domains /
Families
for TATDN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TATDN1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P1N9ProtoNet protein and cluster: Q6P1N9 1 Blocks protein family: IPB001130 TatD-related deoxyribonuclease
UniProtKB/Swiss-Prot: TATD1_HUMAN, Q6P1N9Similarity: Belongs to the TatD DNase family |
Function
for TATDN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TATD1_HUMAN, Q6P1N9Function: Putative deoxyribonuclease (By similarity) Enzyme Numbers (IUBMB): EC 3.1.212 EC 3.1.21.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
TATDN1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TATDN1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TATDN1 (NM_032026) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TATDN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN1 |
|
Pathways & Interactions
for TATDN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TATDN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/28 Interacting proteins for TATDN1 (Q6P1N93 ENSP000002766924) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
|
Drugs & Compounds
for TATDN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TATDN1
Search CenterWatch for drugs/clinical trials and news about TATDN1 / TATD1
|
Transcripts
for TATDN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TATDN1 gene (2 alternative transcripts): NM_001146160.1 NM_032026.3 Unigene Cluster for TATDN1: TatD DNase domain containing 1 Hs.170568 [show with all ESTs]Unigene Representative Sequence: AK12714818/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000522927 ENST00000276692 ENST00000523214(uc003yre.2 uc003yrd.2 uc010mdm.2)
ENST00000523631 ENST00000519548 ENST00000522810 ENST00000518485 ENST00000517678
ENST00000519776 ENST00000521546 ENST00000521973 ENST00000520321 ENST00000522310
ENST00000519232 ENST00000520938 ENST00000523888 ENST00000523152 ENST00000518133
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TATDN1 (NM_032026) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TATDN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN1 |
Additional cDNA sequence: AF212250.1 AK094861.1 AK125270.1 AK127148.1 AK312204.1 AY071865.1 BC007066.1 BC064964.1 NR_027427.1 24/35 DOTS entries (see all 35): DT.452925 DT.92449754 DT.100832280 DT.92429295 DT.92449737 DT.121260186 DT.100793718 DT.453008 DT.95305369 DT.121486196 DT.100793724 DT.95313659 DT.92449741 DT.218477 DT.91803611 DT.95211164 DT.99973193 DT.102837978 DT.121259997 DT.121486172 DT.121486314 DT.121486479 DT.92029098 DT.92040118 24/218 AceView cDNA sequences (see all 218): BU784642 BQ440040 BU150780 BP429407 AV733010 BX332564 BM718113 CR614010 AA736458 BU786374 NM_032026 AA305302 BI712503 BC064964 BM979473 AA378892 AA308284 BU687281 BE884168 BG532054 AI128731 BG547415 AF212250 CB144514
GeneLoc Exon Structure
|
Expression
for TATDN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TATDN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTAAAAT
About this image
See TATDN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TATDN1
SOURCE GeneReport for Unigene cluster: Hs.170568
SABiosciences Custom PCR Arrays for TATDN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TATDN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TATDN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TATDN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TATDN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN1 |
Orthologs
for TATDN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TATDN1 gene from 11/40 species (see all 40) About this table
ENSEMBL Gene Tree for TATDN1 (if available)
TreeFam Gene Tree for TATDN1 (if available) |
Paralogs
for TATDN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TATDN1 gene
- TATDN32
1 SIMAP similar gene for TATDN1 using alignment to 11 protein entries: TATD1_HUMAN (see all proteins):TATDN3
TATDN1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TATDN1
PGOHUM00000238810
|
Genomic Variants
for TATDN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TATDN1 (125500726 - 125551699 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TATDN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TATDN1 |
|
Disorders
/ Diseases
for TATDN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TATDN1 for disorders About GeneDecksing
2  diseases for TATDN1: About MalaCardspheochromocytoma malaria
Export disorders for TATDN1 gene to outside databases
|
Publications
for TATDN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TATDN1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TATDN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning. (PubMed id 14713272)1 Yang Y.-S.... Chen J.-L. (2003)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TATDN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TATDN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TATDN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TATDN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TATDN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TATDN1 gene:
Search GeneIP for patents involving TATDN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TATDN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TATDN1 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TATDN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TATDN1 | | | OriGene Protein Over-expression Lysate for TATDN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TATDN1 | | OriGene 3'-UTR Clone for TATDN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TATDN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TATDN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TATDN1 | | OriGene Custom Protein Services for TATDN1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TATDN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TATDN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TATDN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TATDN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TATDN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TATDN1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TATDN1 |
| |  |  |  |  | | | | |
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 |
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 | | | TATDN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TATDN1 |
|  |  |  |  | | | | ThermoFisher Antibodies for TATDN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TATDN1 |
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