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Aliases for TATDN1 Gene

Aliases for TATDN1 Gene

  • TatD DNase Domain Containing 1 2 3
  • Hepatocarcinoma High Expression Protein 3 4
  • Putative Deoxyribonuclease TATDN1 3
  • EC 3.1.21.- 4
  • EC 3.1.21 64
  • CDA11 3

External Ids for TATDN1 Gene

Summaries for TATDN1 Gene

GeneCards Summary for TATDN1 Gene

TATDN1 (TatD DNase Domain Containing 1) is a Protein Coding gene. Diseases associated with TATDN1 include pheochromocytoma. GO annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is ENSG00000272410.

UniProtKB/Swiss-Prot for TATDN1 Gene

  • Putative deoxyribonuclease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN1 Gene

Genomics for TATDN1 Gene

Genomic Location for TATDN1 Gene

Start:
124,488,485 bp from pter
End:
124,539,458 bp from pter
Size:
50,974 bases
Orientation:
Minus strand

Genomic View for TATDN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TATDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN1 Gene

Regulatory Elements for TATDN1 Gene

Proteins for TATDN1 Gene

  • Protein details for TATDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1N9-TATD1_HUMAN
    Recommended name:
    Putative deoxyribonuclease TATDN1
    Protein Accession:
    Q6P1N9
    Secondary Accessions:
    • B2R5J0
    • Q8TD02
    • Q9BY40

    Protein attributes for TATDN1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33602 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TATDN1 Gene

    Alternative splice isoforms for TATDN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TATDN1 Gene

Proteomics data for TATDN1 Gene at MOPED

Selected DME Specific Peptides for TATDN1 Gene

Post-translational modifications for TATDN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for TATDN1 Gene

Protein Domains for TATDN1 Gene

UniProtKB/Swiss-Prot:

TATD1_HUMAN
Family:
  • Belongs to the TatD DNase family.:
    • Q6P1N9
genes like me logo Genes that share domains with TATDN1: view

No data available for Gene Families for TATDN1 Gene

Function for TATDN1 Gene

Molecular function for TATDN1 Gene

UniProtKB/Swiss-Prot Function: Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN1 Gene

Gene Ontology (GO) - Molecular Function for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004536 deoxyribonuclease activity IBA --
GO:0005515 protein binding IPI 15846844
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TATDN1: view

Phenotypes for TATDN1 Gene

genes like me logo Genes that share phenotypes with TATDN1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TATDN1 Gene

Localization for TATDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TATDN1 Gene COMPARTMENTS Subcellular localization image for TATDN1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043229 intracellular organelle IBA --
genes like me logo Genes that share ontologies with TATDN1: view

Pathways for TATDN1 Gene

SuperPathways for TATDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006308 DNA catabolic process IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN1: view

No data available for Pathways by source for TATDN1 Gene

Transcripts for TATDN1 Gene

Unigene Clusters for TATDN1 Gene

TatD DNase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN1 Gene

No ASD Table

Relevant External Links for TATDN1 Gene

GeneLoc Exon Structure for
TATDN1
ECgene alternative splicing isoforms for
TATDN1

Expression for TATDN1 Gene

mRNA expression in normal human tissues for TATDN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TATDN1 Gene

SOURCE GeneReport for Unigene cluster for TATDN1 Gene Hs.170568

genes like me logo Genes that share expressions with TATDN1: view

Orthologs for TATDN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TATDN1 36
  • 99.33 (n)
  • 98.65 (a)
cow
(Bos Taurus)
Mammalia TATDN1 36
  • 92.37 (n)
  • 93.27 (a)
TATDN1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TATDN1 36
  • 92.52 (n)
  • 93.88 (a)
TATDN1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tatdn1 36
  • 89.02 (n)
  • 90.53 (a)
Tatdn1 16
Tatdn1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TATDN1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TATDN1 37
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TATDN1 36
  • 78.56 (n)
  • 83.5 (a)
TATDN1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TATDN1 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13646 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn1 36
  • 69.37 (n)
  • 77.03 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.862 36
zebrafish
(Danio rerio)
Actinopterygii tatdn1 36
  • 65.99 (n)
  • 70.75 (a)
TATDN1 37
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006162 36
  • 52.4 (n)
  • 52.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3358 36
  • 53.07 (n)
  • 48.74 (a)
CG3358 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crn-2 37
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 28 (a)
OneToMany
-- 39
YBL055C 36
  • 53.2 (n)
  • 43.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19955g 36
  • 49.03 (n)
  • 36.52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52390 36
  • 55.14 (n)
  • 51.53 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11927 36
corn
(Zea mays)
Liliopsida Zm.2802 36
rice
(Oryza sativa)
Liliopsida Os07g0158200 36
  • 56.7 (n)
  • 53.26 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03538 36
  • 48.58 (n)
  • 44.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.08 36
  • 54.48 (n)
  • 45.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10795 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToOne
Species with no ortholog for TATDN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN1 Gene

ENSEMBL:
Gene Tree for TATDN1 (if available)
TreeFam:
Gene Tree for TATDN1 (if available)

Paralogs for TATDN1 Gene

Paralogs for TATDN1 Gene

Pseudogenes.org Pseudogenes for TATDN1 Gene

genes like me logo Genes that share paralogs with TATDN1: view

Variants for TATDN1 Gene

Sequence variations from dbSNP and Humsavar for TATDN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1129465 -- 124,493,132(+) TAAAA(G/T)CAACA intron-variant
rs3812470 -- 124,495,297(-) ACATA(C/T)GCAAA intron-variant
rs3886003 -- 124,501,081(+) CAAGA(C/G)AATCC intron-variant
rs3886004 -- 124,500,767(+) AAAAA(A/C)AAAAC intron-variant
rs4269525 -- 124,535,413(+) TGATT(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN1 Gene

Variant ID Type Subtype PubMed ID
esv274383 CNV Insertion 20981092

Relevant External Links for TATDN1 Gene

HapMap Linkage Disequilibrium report
TATDN1

Disorders for TATDN1 Gene

(1) MalaCards Diseases for TATDN1 Gene

Search for TATDN1 Gene in MalaCards »
genes like me logo Genes that share disorders with TATDN1: view

No data available for UniProtKB/Swiss-Prot for TATDN1 Gene

Publications for TATDN1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning. (PMID: 14713272) Yang Y.-S. … Chen J.-L. (Endocr. Relat. Cancer 2003) 3
  4. Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein. (PMID: 15846844) Kang S.-M. … Oh J.-W. (Proteomics 2005) 3
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3

Products for TATDN1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TATDN1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TATDN1
    • Block miRNA regulation of TATDN1 using miScript Target Protectors

    Sources for TATDN1 Gene

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