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Aliases for TATDN1 Gene

Aliases for TATDN1 Gene

  • TatD DNase Domain Containing 1 2 3 5
  • Hepatocarcinoma High Expression Protein 3 4
  • EC 3.1.21.- 4
  • EC 3.1.21 63
  • CDA11 3

External Ids for TATDN1 Gene

Previous GeneCards Identifiers for TATDN1 Gene

  • GC08M125458
  • GC08M125569
  • GC08M125500
  • GC08M120826

Summaries for TATDN1 Gene

GeneCards Summary for TATDN1 Gene

TATDN1 (TatD DNase Domain Containing 1) is a Protein Coding gene. Diseases associated with TATDN1 include sporadic pheochromocytoma. GO annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is ENSG00000272410.

UniProtKB/Swiss-Prot for TATDN1 Gene

  • Putative deoxyribonuclease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN1 Gene

Genomics for TATDN1 Gene

Regulatory Elements for TATDN1 Gene

Promoters for TATDN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TATDN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TATDN1 Gene

Chromosome:
8
Start:
124,488,485 bp from pter
End:
124,539,458 bp from pter
Size:
50,974 bases
Orientation:
Minus strand

Genomic View for TATDN1 Gene

Genes around TATDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN1 Gene

Proteins for TATDN1 Gene

  • Protein details for TATDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1N9-TATD1_HUMAN
    Recommended name:
    Putative deoxyribonuclease TATDN1
    Protein Accession:
    Q6P1N9
    Secondary Accessions:
    • B2R5J0
    • Q8TD02
    • Q9BY40

    Protein attributes for TATDN1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33602 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TATDN1 Gene

    Alternative splice isoforms for TATDN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TATDN1 Gene

Proteomics data for TATDN1 Gene at MOPED

Selected DME Specific Peptides for TATDN1 Gene

Post-translational modifications for TATDN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for TATDN1 Gene

Protein Domains for TATDN1 Gene

Suggested Antigen Peptide Sequences for TATDN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1N9

UniProtKB/Swiss-Prot:

TATD1_HUMAN :
  • Belongs to the TatD-type hydrolase family.
Family:
  • Belongs to the TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN1: view

No data available for Gene Families for TATDN1 Gene

Function for TATDN1 Gene

Molecular function for TATDN1 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN1 Gene

Gene Ontology (GO) - Molecular Function for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15846844
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
genes like me logo Genes that share ontologies with TATDN1: view
genes like me logo Genes that share phenotypes with TATDN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TATDN1 Gene

Localization for TATDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TATDN1 Gene COMPARTMENTS Subcellular localization image for TATDN1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TATDN1 Gene

Pathways & Interactions for TATDN1 Gene

SuperPathways for TATDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN1: view

No data available for Pathways by source and SIGNOR curated interactions for TATDN1 Gene

Drugs & Compounds for TATDN1 Gene

No Compound Related Data Available

Transcripts for TATDN1 Gene

Unigene Clusters for TATDN1 Gene

TatD DNase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN1 Gene

No ASD Table

Relevant External Links for TATDN1 Gene

GeneLoc Exon Structure for
TATDN1
ECgene alternative splicing isoforms for
TATDN1

Expression for TATDN1 Gene

mRNA expression in normal human tissues for TATDN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TATDN1 Gene

This gene is overexpressed in Skin (8.2) and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TATDN1 Gene



SOURCE GeneReport for Unigene cluster for TATDN1 Gene Hs.170568

genes like me logo Genes that share expression patterns with TATDN1: view

Protein tissue co-expression partners for TATDN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TATDN1 Gene

Orthologs for TATDN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TATDN1 35
  • 99.33 (n)
  • 98.65 (a)
cow
(Bos Taurus)
Mammalia TATDN1 36
  • 93 (a)
OneToOne
TATDN1 35
  • 92.37 (n)
  • 93.27 (a)
dog
(Canis familiaris)
Mammalia TATDN1 35
  • 92.52 (n)
  • 93.88 (a)
TATDN1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tatdn1 36
  • 91 (a)
OneToOne
Tatdn1 16
Tatdn1 35
  • 89.02 (n)
  • 90.53 (a)
oppossum
(Monodelphis domestica)
Mammalia TATDN1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TATDN1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TATDN1 36
  • 84 (a)
OneToOne
TATDN1 35
  • 78.56 (n)
  • 83.5 (a)
lizard
(Anolis carolinensis)
Reptilia TATDN1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13646 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn1 35
  • 69.37 (n)
  • 77.03 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.862 35
zebrafish
(Danio rerio)
Actinopterygii TATDN1 36
  • 67 (a)
OneToOne
tatdn1 35
  • 65.99 (n)
  • 70.75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006162 35
  • 52.4 (n)
  • 52.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3358 36
  • 47 (a)
OneToOne
CG3358 35
  • 53.07 (n)
  • 48.74 (a)
worm
(Caenorhabditis elegans)
Secernentea crn-2 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBL055C 35
  • 53.2 (n)
  • 43.49 (a)
-- 36
  • 28 (a)
OneToMany
-- 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19955g 35
  • 49.03 (n)
  • 36.52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52390 35
  • 55.14 (n)
  • 51.53 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11927 35
corn
(Zea mays)
Liliopsida Zm.2802 35
rice
(Oryza sativa)
Liliopsida Os07g0158200 35
  • 56.7 (n)
  • 53.26 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03538 35
  • 48.58 (n)
  • 44.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.08 35
  • 54.48 (n)
  • 45.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10795 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for TATDN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN1 Gene

ENSEMBL:
Gene Tree for TATDN1 (if available)
TreeFam:
Gene Tree for TATDN1 (if available)

Paralogs for TATDN1 Gene

Paralogs for TATDN1 Gene

Pseudogenes.org Pseudogenes for TATDN1 Gene

genes like me logo Genes that share paralogs with TATDN1: view

Variants for TATDN1 Gene

Sequence variations from dbSNP and Humsavar for TATDN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1129465 -- 124,493,132(+) TAAAA(G/T)CAACA intron-variant
rs4535724 -- 124,516,535(+) GAACT(C/T)CTGAG intron-variant
rs4540394 -- 124,517,959(+) gtaat(C/G)ccagc intron-variant
rs4358788 -- 124,516,406(+) CAAGC(A/G)ATCCT intron-variant
rs4457314 -- 124,491,883(+) TTTAA(A/G)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN1 Gene

Variant ID Type Subtype PubMed ID
esv274383 CNV Insertion 20981092

Variation tolerance for TATDN1 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TATDN1 Gene

HapMap Linkage Disequilibrium report
TATDN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN1 Gene

Disorders for TATDN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TATDN1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sporadic pheochromocytoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TATDN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TATDN1
genes like me logo Genes that share disorders with TATDN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TATDN1 Gene

Publications for TATDN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for TATDN1 Gene

Sources for TATDN1 Gene

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