Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TATDN1 Gene

Aliases for TATDN1 Gene

  • TatD DNase Domain Containing 1 2 3 5
  • Hepatocarcinoma High Expression Protein 3 4
  • Putative Deoxyribonuclease TATDN1 3
  • EC 3.1.21.- 4
  • EC 3.1.21 61
  • CDA11 3

External Ids for TATDN1 Gene

Previous GeneCards Identifiers for TATDN1 Gene

  • GC08M125458
  • GC08M125569
  • GC08M125500
  • GC08M120826

Summaries for TATDN1 Gene

GeneCards Summary for TATDN1 Gene

TATDN1 (TatD DNase Domain Containing 1) is a Protein Coding gene. Diseases associated with TATDN1 include Sporadic Pheochromocytoma. GO annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is TATDN2.

UniProtKB/Swiss-Prot for TATDN1 Gene

  • Putative deoxyribonuclease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN1 Gene

Genomics for TATDN1 Gene

Regulatory Elements for TATDN1 Gene

Enhancers for TATDN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F124718 0.9 Ensembl ENCODE 15.8 -181.1 -181143 4.8 ELF3 HDAC1 ARID4B THRB RAD21 RARA YY1 SLC30A9 CREM MIXL1 TATDN1 NDUFB9 ZNF572 MIR6844 MTSS1 GC08P124718
GH08F124562 0.8 ENCODE 11.5 -24.8 -24816 4.3 DMAP1 RAD21 RARA YY1 GATA2 ETV6 CREM THAP11 CEBPB REST TATDN1 MIR6844 NDUFB9 MTSS1 LOC105375744 SQLE TRMT12 LOC105375740
GH08F124573 0.8 Ensembl ENCODE 11.5 -34.5 -34545 1.9 RNF2 MTA2 TAL1 BHLHE40 DPF2 ARID1B FOXK2 GATA2 NCOR1 IKZF1 MIR6844 NDUFB9 TATDN1 MTSS1 TRMT12 LOC105375744 SQLE LOC105375740 GC08P124592
GH08F124509 0.2 ENCODE 11.2 +28.9 28883 1.8 ZNF366 FOS FOXP2 ZKSCAN1 TRMT12 ENSG00000253106 RNF139 RNF139-AS1 MIR6844 NDUFB9 TATDN1 LOC105375740
GH08F124583 0.7 ENCODE 11.2 -45.0 -44980 1.3 PKNOX1 RNF2 TAL1 TSC22D4 DPF2 FOSL1 ZNF366 IKZF1 ZNF512 FOS MTSS1 MIR6844 TATDN1 NDUFB9 LOC105375744 SQLE ZNF572 TRMT12 LOC105375740 GC08P124592
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TATDN1 on UCSC Golden Path with GeneCards custom track

Promoters for TATDN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TATDN1 Gene

124,488,485 bp from pter
124,539,458 bp from pter
50,974 bases
Minus strand

Genomic View for TATDN1 Gene

Genes around TATDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN1 Gene

Proteins for TATDN1 Gene

  • Protein details for TATDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative deoxyribonuclease TATDN1
    Protein Accession:
    Secondary Accessions:
    • B2R5J0
    • Q8TD02
    • Q9BY40

    Protein attributes for TATDN1 Gene

    297 amino acids
    Molecular mass:
    33602 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TATDN1 Gene

    Alternative splice isoforms for TATDN1 Gene


neXtProt entry for TATDN1 Gene

Selected DME Specific Peptides for TATDN1 Gene

Post-translational modifications for TATDN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TATDN1 Gene

Protein Domains for TATDN1 Gene

Suggested Antigen Peptide Sequences for TATDN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TatD-type hydrolase family.
  • Belongs to the TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN1: view

No data available for Gene Families for TATDN1 Gene

Function for TATDN1 Gene

Molecular function for TATDN1 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN1 Gene

Gene Ontology (GO) - Molecular Function for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004536 deoxyribonuclease activity IBA --
GO:0005515 protein binding IPI 15846844
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
genes like me logo Genes that share ontologies with TATDN1: view
genes like me logo Genes that share phenotypes with TATDN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TATDN1 Gene

Localization for TATDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN1 Gene

Subcellular locations from

Jensen Localization Image for TATDN1 Gene COMPARTMENTS Subcellular localization image for TATDN1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TATDN1: view

Pathways & Interactions for TATDN1 Gene

SuperPathways for TATDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0006308 DNA catabolic process IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN1: view

No data available for Pathways by source and SIGNOR curated interactions for TATDN1 Gene

Transcripts for TATDN1 Gene

Unigene Clusters for TATDN1 Gene

TatD DNase domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN1 Gene

No ASD Table

Relevant External Links for TATDN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TATDN1 Gene

mRNA expression in normal human tissues for TATDN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TATDN1 Gene

This gene is overexpressed in Skin (8.2) and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TATDN1 Gene

Protein tissue co-expression partners for TATDN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TATDN1 Gene:


SOURCE GeneReport for Unigene cluster for TATDN1 Gene:

genes like me logo Genes that share expression patterns with TATDN1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TATDN1 Gene

Orthologs for TATDN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TATDN1 34
  • 99.33 (n)
(Canis familiaris)
Mammalia TATDN1 34 35
  • 92.52 (n)
(Bos Taurus)
Mammalia TATDN1 34 35
  • 92.37 (n)
(Mus musculus)
Mammalia Tatdn1 34 16 35
  • 89.02 (n)
(Monodelphis domestica)
Mammalia TATDN1 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia TATDN1 35
  • 80 (a)
(Gallus gallus)
Aves TATDN1 34 35
  • 78.56 (n)
(Anolis carolinensis)
Reptilia TATDN1 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn1 34
  • 69.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13646 34
(Danio rerio)
Actinopterygii TATDN1 35
  • 67 (a)
tatdn1 34
  • 65.99 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.862 34
fruit fly
(Drosophila melanogaster)
Insecta CG3358 34 35
  • 53.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006162 34
  • 52.4 (n)
(Caenorhabditis elegans)
Secernentea crn-2 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBL055C 34
  • 53.2 (n)
-- 35
  • 28 (a)
-- 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19955g 34
  • 49.03 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52390 34
  • 55.14 (n)
(Oryza sativa)
Liliopsida Os07g0158200 34
  • 56.7 (n)
(Hordeum vulgare)
Liliopsida Hv.11927 34
(Zea mays)
Liliopsida Zm.2802 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.08 34
  • 54.48 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03538 34
  • 48.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10795 34
Species where no ortholog for TATDN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN1 Gene

Gene Tree for TATDN1 (if available)
Gene Tree for TATDN1 (if available)

Paralogs for TATDN1 Gene

Paralogs for TATDN1 Gene Pseudogenes for TATDN1 Gene

genes like me logo Genes that share paralogs with TATDN1: view

Variants for TATDN1 Gene

Sequence variations from dbSNP and Humsavar for TATDN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs755557988 Likely benign 124,539,209(+) GGGAC(A/C/T)CTACC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs140365193 Benign 124,539,144(+) CGTGC(A/G)GTTTC upstream-variant-2KB, utr-variant-5-prime
rs147044660 Benign 124,539,210(+) GGACC(C/G/T)TACCT upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs79736226 Benign 124,539,151(+) TTTCC(C/G/T)GGCTC upstream-variant-2KB, utr-variant-5-prime
rs10091243 -- 124,531,843(+) ACCCC(A/G)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN1 Gene

Variant ID Type Subtype PubMed ID
esv3310111 CNV mobile element insertion 20981092
esv3335107 CNV insertion 20981092
nsv951466 CNV duplication 24416366

Variation tolerance for TATDN1 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TATDN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN1 Gene

Disorders for TATDN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TATDN1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sporadic pheochromocytoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TATDN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TATDN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TATDN1 Gene

Publications for TATDN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3 64

Products for TATDN1 Gene

Sources for TATDN1 Gene

Loading form....