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TAT Gene

protein-coding   GIFtS: 64
GCID: GC16M071599

Tyrosine Aminotransferase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine Aminotransferase1 2
L-Tyrosine:2-Oxoglutarate Aminotransferase2 3
EC 2.6.1.53 8
Tyrosine Aminotransferase, Cytosolic2

External Ids:    HGNC: 115731   Entrez Gene: 68982   Ensembl: ENSG000001986507   OMIM: 6130185   UniProtKB: P177353   

Export aliases for TAT gene to outside databases

Previous GC identifers: GC16M062492 GC16M072323 GC16M071336 GC16M071376 GC16M070158 GC16M057368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAT Gene:
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and
catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia
(type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible
mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAT Gene:
TAT (tyrosine aminotransferase) is a protein-coding gene. Diseases associated with TAT include hanhart syndrome, and tyrosinemia type ii. GO annotations related to this gene include L-phenylalanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding. An important paralog of this gene is CCBL1.

UniProtKB/Swiss-Prot: ATTY_HUMAN, P17735
Function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze
the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity
and transaminase activity towards phenylalanine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAT gene promoter:
         TBP   Sp1   AP-1   ATF-2   YY1   E2F   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAT promoter sequence
   Search Chromatin IP Primers for TAT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.1

TAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAT gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071599:  view genomic region     (about GC identifiers)

Start:
71,599,563 bp from pter      End:
71,611,033 bp from pter
Size:
11,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATTY_HUMAN, P17735 (See protein sequence)
Recommended Name: Tyrosine aminotransferase  
Size: 454 amino acids; 50399 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (Probable)
1 PDB 3D structure from and Proteopedia for TAT:
3DYD (3D)    
Secondary accessions: B2R8I1 D3DWS2

Explore the universe of human proteins at neXtProt for TAT: NX_P17735

Explore proteomics data for TAT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TAT (P17735) (see all 5)
     KLSQRILGPCT  VPILSCGGLAKRWLVPGWR  GWILIHDRRDIFGNEIRDGL  PSGAMYLMVGIEMEHFPEFENDVEFTE 


    See TAT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000344.1  
    ENSEMBL proteins: 
     ENSP00000348234  
    Reactome Protein details: P17735

    TAT Human Recombinant Protein Products:

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    Novus Biologicals TAT Protein
    Novus Biologicals TAT Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TAT

    TAT Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TAT

    TAT Assay Products:

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    Cloud-Clone Corp. ELISAs for TAT
    Cloud-Clone Corp. CLIAs for TAT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR021178 Tyrosine_transaminase
     IPR004838 NHTrfase_class1_PyrdxlP-BS
     IPR005958 TyrNic_aminoTrfase

    Graphical View of Domain Structure for InterPro Entry P17735

    ProtoNet protein and cluster: P17735

    2 Blocks protein domains:
    IPB004839 Aminotransferase
    IPB011715 Tyrosine aminotransferase ubiquitination region


    UniProtKB/Swiss-Prot: ATTY_HUMAN, P17735
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


    TAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATTY_HUMAN, P17735
    Function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze
    the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity
    and transaminase activity towards phenylalanine
    Catalytic activity: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate

         Genatlas biochemistry entry for TAT:
    tyrosine aminotransferase,catalyzing the first step of tyrosine catabolism

         Enzyme Number (IUBMB): EC 2.6.1.51 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004838L-tyrosine:2-oxoglutarate aminotransferase activity TAS--
    GO:0008483transaminase activity ----
    GO:0016597amino acid binding IEA--
    GO:0016829lyase activity ----
    GO:0030170pyridoxal phosphate binding IEA--
         
    TAT for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAT

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAT:
    hsa-mir-1 (MIRT023561)

    Block miRNA regulation of human, mouse, rat TAT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAT (see all 28):
    hsa-miR-125a-5p hsa-miR-16-2* hsa-miR-202 hsa-miR-938 hsa-miR-3653 hsa-miR-578 hsa-miR-3658 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTAT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAT
    Predesigned siRNA for gene silencing in human, mouse, rat TAT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAT

    Clone
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    OriGene clones in human, mouse for TAT (see all 8)
    OriGene ORF clones in mouse, rat for TAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAT (NM_139266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAT

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TAT 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton2
    extracellular2
    mitochondrion2
    plasma membrane2
    endosome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    TAT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAT About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tyrosine degradation I0.00
    Phenylalanine and tyrosine catabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Phenylalanine, tyrosine and tryptophan biosynthesis0.00
    Tyrosine metabolism0.36
    44-hydroxybenzoate biosynthesis
    4-hydroxybenzoate biosynthesis
    4-hydroxyphenylpyruvate biosynthesis0.00
    5Ubiquinol biosynthesis
    Ubiquinone and other terpenoid-quinone biosynthesis0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for TAT
        FOXA2 and FOXA3 transcription factor networks
    tyrosine degradation I
    4-hydroxybenzoate biosynthesis
    4-hydroxyphenylpyruvate biosynthesis

    1 Reactome Pathway for TAT
        Phenylalanine and tyrosine catabolism


    Selected Kegg Pathways  (Kegg details for TAT) (see all 7):
        Ubiquinone and other terpenoid-quinone biosynthesis
    Cysteine and methionine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    Phenylalanine, tyrosine and tryptophan biosynthesis

    UniProtKB/Swiss-Prot: ATTY_HUMAN, P17735
    Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step
    2/6


    TAT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAT: 

              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAT (P177353 ENSP000003482344) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000227333Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00061032-oxoglutarate metabolic process IDA7999802
    GO:0006520cellular amino acid metabolic process ----
    GO:0006536glutamate metabolic process IDA7999802
    GO:0006559L-phenylalanine catabolic process TAS--
    GO:0006572tyrosine catabolic process IDA7999802

    TAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAT (ATTY)

    10 HMDB Compounds for TAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Oxo-4-methylthiobutanoic acid2-Oxo-4-methylthiobutanoate (see all 17)583-92-6--
    4-Hydroxyphenylpyruvic acid(p-Hydroxyphenyl)pyruvate (see all 25)156-39-8--
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    L-Tyrosine(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)60-18-4--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--
    Phenylpyruvic acid2-Oxo-3-phenylpropanoate (see all 16)156-06-9--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    4 DrugBank Compounds for TAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16902803 12441383 12798391 16570355 16466641
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--2890101 16666560 11299302 9356140
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--16840830
    L-Tyrosine2-Amino-3-(p-hydroxyphenyl)propionic acid (see all 3)60-18-4target--17389761

    Selected Novoseek inferred chemical compound relationships for TAT gene (see all 104)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    argininamide 81.9 6 10780483 (1), 15273324 (1), 17150503 (1), 12475232 (1) (see all 5)
    polytar 78.1 4 7584083 (1), 2039768 (1)
    pnu 145156e 70.8 3 9840289 (2)
    st-pc 58.5 3 17266559 (2), 10544137 (1)
    tat-1 57.9 4 1548750 (2), 10364329 (2)
    neamine 56.6 1 10747964 (1)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 56.3 4 10757782 (1), 1756726 (1), 20370601 (1)
    tyrosine 55.1 217 8100416 (4), 7988415 (4), 1967940 (3), 1359707 (3) (see all 99)
    4-thiouracil 52.3 1 8639596 (1)
    flavopiridol 46.6 2 10906320 (1), 20370601 (1)



    TAT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAT gene: 
    NM_000353.2  

    Unigene Cluster for TAT:

    Tyrosine aminotransferase
    Hs.161640  [show with all ESTs]
    Unigene Representative Sequence: NM_000353
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355962(uc002fap.2) ENST00000564007 ENST00000566094(uc002faq.3)
    ENST00000566010(uc002far.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TAT (see all 28):
    hsa-miR-125a-5p hsa-miR-16-2* hsa-miR-202 hsa-miR-938 hsa-miR-3653 hsa-miR-578 hsa-miR-3658 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTAT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAT
    Clone
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    OriGene ORF clones in mouse, rat for TAT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAT (NM_139266)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TAT
    OriGene qSTAR qPCR primer pairs in human, mouse for TAT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAT
      QuantiTect SYBR Green Assays in human, mouse, rat TAT
      QuantiFast Probe-based Assays in human, mouse, rat TAT

    Additional mRNA sequence: 

    AK313380.1 BC020707.1 BC022292.1 BC130534.1 X52520.1 X55675.1 

    7 DOTS entries:

    DT.410956  DT.92445496  DT.91971153  DT.91971151  DT.120656384  DT.91943210  DT.95142691 

    Selected AceView cDNA sequences (see all 66):

    AV651993 CB161938 AV649381 AV652015 X55675 BX505436 BC020707 BC022292 
    X52520 BG567891 BX100092 BG565770 BG566900 AV659461 BG568198 NM_000353 
    AV647497 BX951447 BG533462 BG533529 AV646142 BG567671 BP357323 CB153377 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TAT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                -                                                           -               
    SP2:                                                                          -                 -               
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for TAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAT expression in normal human tissues (normalized intensities)      TAT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTGGTGA
    TAT Expression
    About this image


    TAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 6 entries
             Hepatocytes Liver Lobule
             Hepatocyte-like cells
             Human Hepatocyte (HH)   
    TAT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.161640
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAT: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TAT
    OriGene qSTAR qPCR primer pairs in human, mouse for TAT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAT
    QuantiTect SYBR Green Assays in human, mouse, rat TAT
    QuantiFast Probe-based Assays in human, mouse, rat TAT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAT gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tat1 , 5 tyrosine aminotransferase1, 5 86.2(n)1
    92.07(a)1
      8 (57.38 cM)5
    2347241  NM_146214.31  NP_666326.11 
     1099904375 
    chicken
    (Gallus gallus)
    Aves TAT1 tyrosine aminotransferase 76.28(n)
    82.16(a)
      415884  XM_004944357.1  XP_004944414.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAT6
    tyrosine aminotransferase
    78(a)
    1 ↔ 1
    GL343483.1(284967-291626)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.321862 Xenopus laevis transcribed sequence with moderate similarity more 78.2(n)    BJ626626.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tat1 tyrosine aminotransferase 68.05(n)
    72.81(a)
      561410  NM_001077554.1  NP_001071022.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14611 , 3 tyrosine aminotransferase3
    CG14611
    52(a)3
    57.13(n)1
    52.74(a)1
      323811  NM_132725.21  NP_572953.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F42D1.23
    tatn-11
    tyrosine aminotransferase3
    tatn-11
    44(a)3
    51.21(n)1
    44.2(a)1
      X(14826283-14827867)3
    1815741  NM_078053.51  NP_510454.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HIS5(YIL116W)4 Histidinol-phosphate aminotransferase, catalyzes the more   --   9(142928-144085) 854690  NP_012150.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G361601 AT5G36160 47.86(n)
    35.01(a)
      833613  NM_123007.5  NP_198465.3 
    rice
    (Oryza sativa)
    Liliopsida Os02g03027001 Os02g0302700 47.04(n)
    38.67(a)
      4329101  NM_001053163.1  NP_001046628.1 


    ENSEMBL Gene Tree for TAT (if available)
    TreeFam Gene Tree for TAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAT gene
    CCBL12  CCBL22  

    TAT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAT (see all 138)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289342771,2,4
    Tyrosinemia 2 (TYRO2)4--see VAR_0005602 mis40--------
    rs2008026541,2
    C--57380974(+) AAAAAA/TATATA 1 -- us2k10--------
    rs1863234571,2
    --72618213(+) TCTTCA/GCTGAC 1 -- int10--------
    rs2009318651,2
    --72618382(+) TACAA-/TTTTTT 1 -- int10--------
    rs80641081,2
    C,F--72618389(+) TTTTTT/AAAAAA 1 -- int12Minor allele frequency- A:0.06WA NA 238
    rs1912733641,2
    --72618421(+) TTTTTA/TAAAAT 1 -- int10--------
    rs1390852471,2
    --72618430(+) ATAATG/TTTTTA 1 -- int10--------
    rs1498965071,2
    C--72618504(+) CTTTCA/GGCCTC 1 -- int10--------
    rs1825474161,2
    --72618590(+) TTAGTG/TACCCC 1 -- int10--------
    rs1439653701,2
    --72618610(+) AGAAGC/TCTTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TAT (71599563 - 71611033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TAT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7285OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TAT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAT
    DNA2.0 Custom Variant and Variant Library Synthesis for TAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613018   
    OMIM disorders: 276600  
    UniProtKB/Swiss-Prot: ATTY_HUMAN, P17735
  • Tyrosinemia 2 (TYRO2) [MIM:276600]: An inborn error of metabolism characterized by elevations of tyrosine
    in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis,
    painful corneal ulcers, and mental retardation. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for TAT (see all 79):    About MalaCards
    hanhart syndrome    tyrosinemia type ii    small cell sarcoma    aids dementia complex
    tyrosinemia    progressive multifocal leukoencephalopathy    disseminated intravascular coagulation    focal glomerulosclerosis
    parametritis    corneal ulcer    kaposi's sarcoma    north american indian childhood cirrhosis
    japanese encephalitis    liver cirrhosis    encephalitis    alcoholic liver cirrhosis
    hyperphenylalaninemia    palmoplantar keratosis    acquired immunodeficiency syndrome    keratitis

    5 diseases from the University of Copenhagen DISEASES database for TAT:
    Tyrosinemia     Acquired immunodeficiency syndrome     Kaposi's sarcoma     Hepatocellular carcinoma
    Keratitis

    TAT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for TAT gene (see all 87)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 91.1 511 12605891 (4), 8434019 (4), 17229693 (3), 10665489 (3) (see all 99)
    tyrosinemia type ii 84.1 11 16640556 (2), 16050420 (1), 16602095 (1), 9544843 (1) (see all 8)
    equine infectious anemia 74.2 9 8178449 (2), 10964778 (2), 8906885 (1), 1312617 (1) (see all 6)
    aids dementia complex 70.9 6 15801785 (1), 19886840 (1), 17505985 (1), 9278385 (1) (see all 6)
    aids 66.7 79 10477700 (2), 10812220 (2), 7584083 (2), 14984439 (2) (see all 60)
    hiv infections 63 40 19526283 (2), 15869407 (1), 15976177 (1), 8212135 (1) (see all 37)
    kaposi sarcoma 62.1 23 16436505 (2), 8416373 (1), 12055184 (1), 15942664 (1) (see all 22)
    hiv encephalitis 59.8 1 10751368 (1)
    aids-related malignancies 57 2 10799578 (1)
    dementia 51.8 13 11060751 (1), 15710248 (1), 16356633 (1), 17078933 (1) (see all 11)

    Genatlas disease: TAT
    tyrosinemia II,oculocutaneous,Richner-Hanhart syndrome,with palmoplantar keratoderma (hyperkeratosis),ectodermal
    dysplasia and corneal dystrophy

    Genetic Association Database (GAD): TAT

    Export disorders for TAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAT gene, integrated from 10 sources (see all 814):
    (articles sorted by number of sources associating them with TAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human tyrosine aminotransferase cDNA. (PubMed id 7999802)1, 2, 9 Seralini G.E.... Labrie F. (Biochim. Biophys. Acta 1995)
    2. Nucleotide sequence of the human tyrosine aminotransferase gene. (PubMed id 7908801)1, 2, 9 Zelenin S.M. and Mertvetsov N.P. (Bioorg. Khim. 1994)
    3. Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. (PubMed id 1357662)1, 2, 9 Natt E.... Scherer G. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    4. Isolation and characterization of the human tyrosine aminotransferase gene. (PubMed id 1973834)1, 2, 9 Rettenmeier R.... Scherer G. (Nucleic Acids Res. 1990)
    5. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1, 4 Kettunen J....Ripatti S. (Nat. Genet. 2012)
    6. Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. (PubMed id 11299302)7, 9 Patrizio M....Levi G. (J. Neurochem. 2001)
    7. Tyrosine aminotransferase and gamma-glutamyl transferase activity in human fetal hepatocyte primary cultures under proliferative conditions. (PubMed id 15027097)1, 9 Rehman K.K....Habibullah C.M. (Cell Biochem. Funct. 2004)
    8. The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PubMed id 12588988)1, 9 Hoque M....Pe'ery T. (Mol. Cell. Biol. 2003)
    9. TAT gene mutation analysis in three Palestinian kindreds with oculocutaneous tyrosinaemia type II; characterization of a silent exonic transversion that causes complete missplicing by exon 11 skipping. (PubMed id 16917729)1, 9 Maydan G....Korman S.H. (J. Inherit. Metab. Dis. 2006)
    10. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. (PubMed id 16892178)1, 9 Baharvand H....Farrokhi A. (Int. J. Dev. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6898 HGNC: 11573 AceView: TAT Ensembl:ENSG00000198650 euGenes: HUgn6898
    ECgene: TAT Kegg: 6898 H-InvDB: TAT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAT Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TAT[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAT gene:
    Search GeneIP for patents involving TAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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