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Aliases for TASP1 Gene

Aliases for TASP1 Gene

  • Taspase, Threonine Aspartase, 1 2 3
  • C20orf13 3 4 6
  • Taspase-1 3 4
  • Chromosome 20 Open Reading Frame 13 2
  • Threonine Aspartase 1 3
  • EC 3.4.25.- 4
  • DJ585I14.2 3
  • Taspase 1 3

External Ids for TASP1 Gene

Previous Symbols for TASP1 Gene

  • C20orf13

Summaries for TASP1 Gene

Entrez Gene Summary for TASP1 Gene

  • This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TASP1 Gene

TASP1 (Taspase, Threonine Aspartase, 1) is a Protein Coding gene. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is AGA.

UniProtKB/Swiss-Prot for TASP1 Gene

  • Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.

Gene Wiki entry for TASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TASP1 Gene

Genomics for TASP1 Gene

Genomic Location for TASP1 Gene

Start:
13,389,389 bp from pter
End:
13,638,940 bp from pter
Size:
249,552 bases
Orientation:
Minus strand

Genomic View for TASP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TASP1 Gene

Regulatory Elements for TASP1 Gene

Proteins for TASP1 Gene

  • Protein details for TASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6P5-TASP1_HUMAN
    Recommended name:
    Threonine aspartase 1
    Protein Accession:
    Q9H6P5
    Secondary Accessions:
    • B7Z690
    • B7Z963
    • Q5TDU9
    • Q9BQN0
    • Q9NQ08
    • Q9NTS6
    • Q9NXJ2

    Protein attributes for TASP1 Gene

    Size:
    420 amino acids
    Molecular mass:
    44455 Da
    Quaternary structure:
    • Intramolecular proteolysis generates 2 subunits, alpha and beta, which reassemble through a non-covalent association to form the fully active enzyme
    SequenceCaution:
    • Sequence=CAC01509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TASP1 Gene

    Alternative splice isoforms for TASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TASP1 Gene

Proteomics data for TASP1 Gene at MOPED

Post-translational modifications for TASP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TASP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TASP1 Gene

Domains for TASP1 Gene

Protein Domains for TASP1 Gene

UniProtKB/Swiss-Prot:

TASP1_HUMAN
Family:
  • Belongs to the Ntn-hydrolase family.:
    • Q9H6P5
genes like me logo Genes that share domains with TASP1: view

No data available for Gene Families for TASP1 Gene

Function for TASP1 Gene

Molecular function for TASP1 Gene

UniProtKB/Swiss-Prot Function: Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.

Enzyme Numbers (IUBMB) for TASP1 Gene

Gene Ontology (GO) - Molecular Function for TASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004298 threonine-type endopeptidase activity IMP 14636557
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with TASP1: view
genes like me logo Genes that share phenotypes with TASP1: view

Animal Models for TASP1 Gene

MGI Knock Outs for TASP1:

miRNA for TASP1 Gene

miRTarBase miRNAs that target TASP1

No data available for Transcription Factor Targeting and HOMER Transcription for TASP1 Gene

Localization for TASP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TASP1 Gene COMPARTMENTS Subcellular localization image for TASP1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TASP1 Gene

Pathways for TASP1 Gene

SuperPathways for TASP1 Gene

No Data Available

Interacting Proteins for TASP1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338624%0d%0a9606.ENSP00000452454%0d%0a9606.ENSP00000436786%0d%0a9606.ENSP00000382133%0d%0a
Selected Interacting proteins: ENSP00000338624 Q9H6P5-TASP1_HUMAN for TASP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IMP 22829979
GO:0008152 metabolic process --
GO:0045893 positive regulation of transcription, DNA-templated IMP 14636557
genes like me logo Genes that share ontologies with TASP1: view

No data available for Pathways by source for TASP1 Gene

Transcripts for TASP1 Gene

Unigene Clusters for TASP1 Gene

Taspase, threonine aspartase, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TASP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2:

Relevant External Links for TASP1 Gene

GeneLoc Exon Structure for
TASP1
ECgene alternative splicing isoforms for
TASP1

Expression for TASP1 Gene

mRNA expression in normal human tissues for TASP1 Gene

mRNA differential expression in normal tissues according to GTEx for TASP1 Gene

This gene is overexpressed in Artery - Tibial (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TASP1 Gene

SOURCE GeneReport for Unigene cluster for TASP1 Gene Hs.348297

genes like me logo Genes that share expressions with TASP1: view

Orthologs for TASP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TASP1 36
  • 99.44 (n)
  • 99.76 (a)
TASP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C20ORF13 37
  • 97 (a)
OneToOne
TASP1 36
  • 91.75 (n)
  • 97.38 (a)
dog
(Canis familiaris)
Mammalia TASP1 36
  • 94.6 (n)
  • 97.86 (a)
TASP1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tasp1 36
  • 91.9 (n)
  • 94.52 (a)
Tasp1 16
Tasp1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TASP1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TASP1 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tasp1 36
  • 91.19 (n)
  • 94.05 (a)
chicken
(Gallus gallus)
Aves TASP1 36
  • 82.16 (n)
  • 91.28 (a)
TASP1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TASP1 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tasp1 36
  • 77.88 (n)
  • 84.62 (a)
zebrafish
(Danio rerio)
Actinopterygii tasp1 36
  • 74.1 (n)
  • 78.74 (a)
tasp1 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002531 36
  • 46.91 (n)
  • 46.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taspase1 36
  • 47.35 (n)
  • 42.9 (a)
Taspase1 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K01G5.9 36
  • 44.5 (n)
  • 36.5 (a)
K01G5.9 37
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00590 36
  • 46.95 (n)
  • 40.29 (a)
rice
(Oryza sativa)
Liliopsida Os04g0682500 36
  • 45.83 (n)
  • 40.28 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01757 36
  • 46.49 (n)
  • 40.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC823.09c 36
  • 45.19 (n)
  • 35.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToOne
Species with no ortholog for TASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TASP1 Gene

ENSEMBL:
Gene Tree for TASP1 (if available)
TreeFam:
Gene Tree for TASP1 (if available)

Paralogs for TASP1 Gene

Paralogs for TASP1 Gene

Selected SIMAP similar genes for TASP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TASP1 Gene

genes like me logo Genes that share paralogs with TASP1: view

Variants for TASP1 Gene

Sequence variations from dbSNP and Humsavar for TASP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs743183 -- 13,416,580(-) GTCTG(A/T)TACAG intron-variant
rs768595 -- 13,412,521(-) cactt(C/T)taatt intron-variant
rs910969 -- 13,527,225(+) AAAAG(A/G)AAAAG intron-variant
rs911014 -- 13,428,856(+) CAAGA(A/G)TCAAC intron-variant
rs927122 -- 13,430,623(+) aaatc(A/G)gacac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TASP1 Gene

Variant ID Type Subtype PubMed ID
esv29075 CNV Gain 19812545
nsv178651 CNV Loss 16902084
nsv520595 CNV Loss 19592680
esv1922220 CNV Deletion 18987734
nsv912687 CNV Loss 21882294
nsv912688 CNV Loss 21882294
nsv912689 CNV Gain 21882294
esv2674371 CNV Deletion 23128226

Relevant External Links for TASP1 Gene

HapMap Linkage Disequilibrium report
TASP1

Disorders for TASP1 Gene

No disorders were found for TASP1 Gene.

No data available for UniProtKB/Swiss-Prot for TASP1 Gene

Publications for TASP1 Gene

  1. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. (PMID: 14636557) Hsieh J.J.-D. … Korsmeyer S.J. (Cell 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. (PMID: 16216576) Khan J.A. … Tong L. (Structure 2005) 3 4
  5. EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas. (PMID: 18395097) Niehof M. … Borlak J. (Gastroenterology 2008) 3 23

Products for TASP1 Gene

Sources for TASP1 Gene

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