Aliases for TASP1 Gene
External Ids for TASP1 Gene
Previous HGNC Symbols for TASP1 Gene
Previous GeneCards Identifiers for TASP1 Gene
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TASP1 Gene
TASP1 (Taspase, Threonine Aspartase, 1) is a Protein Coding gene. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is AGA.
UniProtKB/Swiss-Prot for TASP1 Gene
Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.