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Aliases for TAS2R8 Gene

Aliases for TAS2R8 Gene

  • Taste Receptor, Type 2, Member 8 2 3
  • T2R8 3 4 6
  • TRB5 3 4 6
  • Taste Receptor Family B Member 5 3 4
  • Taste Receptor, Family B, Member 5 3
  • Taste Receptor Type 2 Member 8 3

External Ids for TAS2R8 Gene

Summaries for TAS2R8 Gene

Entrez Gene Summary for TAS2R8 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R8 Gene

TAS2R8 (Taste Receptor, Type 2, Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R8 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Wiki entry for TAS2R8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R8 Gene

Genomics for TAS2R8 Gene

Genomic Location for TAS2R8 Gene

Start:
10,806,051 bp from pter
End:
10,807,293 bp from pter
Size:
1,243 bases
Orientation:
Minus strand

Genomic View for TAS2R8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R8 Gene

Regulatory Elements for TAS2R8 Gene

Proteins for TAS2R8 Gene

  • Protein details for TAS2R8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW2-TA2R8_HUMAN
    Recommended name:
    Taste receptor type 2 member 8
    Protein Accession:
    Q9NYW2
    Secondary Accessions:
    • Q4KN29
    • Q645Y2

    Protein attributes for TAS2R8 Gene

    Size:
    309 amino acids
    Molecular mass:
    35877 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R8 Gene

Proteomics data for TAS2R8 Gene at MOPED

Post-translational modifications for TAS2R8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn167

Other Protein References for TAS2R8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R8 Gene

Domains for TAS2R8 Gene

Gene Families for TAS2R8 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TA2R8_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • Q9NYW2
genes like me logo Genes that share domains with TAS2R8: view

Function for TAS2R8 Gene

Molecular function for TAS2R8 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Ontology (GO) - Molecular Function for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R8: view
genes like me logo Genes that share phenotypes with TAS2R8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R8 Gene

Localization for TAS2R8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R8 Gene COMPARTMENTS Subcellular localization image for TAS2R8 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R8: view

Pathways for TAS2R8 Gene

genes like me logo Genes that share pathways with TAS2R8: view

Pathways by source for TAS2R8 Gene

1 KEGG pathway for TAS2R8 Gene

Interacting Proteins for TAS2R8 Gene

Gene Ontology (GO) - Biological Process for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R8: view

Compounds for TAS2R8 Gene

(3) BitterDB Compounds for TAS2R8 Gene

Compound Smiles Cas Number
chloramphenicol OC[C@](NC(=O)C(Cl)Cl)[C](O)c1ccc(cc1)[N+](=O)[O-]
denatonium benzoate CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 3734-33-6
Parthenolide CC1=C/CC[C@@]2(C)O[C]2[C]3OC(=O)C(=C)[C@]3CC1
genes like me logo Genes that share compounds with TAS2R8: view

Transcripts for TAS2R8 Gene

mRNA/cDNA for TAS2R8 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R8 Gene

Taste receptor, type 2, member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R8 Gene

No ASD Table

Relevant External Links for TAS2R8 Gene

GeneLoc Exon Structure for
TAS2R8
ECgene alternative splicing isoforms for
TAS2R8

Expression for TAS2R8 Gene

mRNA expression in normal human tissues for TAS2R8 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R8 Gene

This gene is overexpressed in Brain - Cerebellum (5.9), Brain - Cortex (5.2), and Brain - Cerebellar Hemisphere (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TAS2R8 Gene

SOURCE GeneReport for Unigene cluster for TAS2R8 Gene Hs.533755

mRNA Expression by UniProt/SwissProt for TAS2R8 Gene

Q9NYW2-TA2R8_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R8: view

Orthologs for TAS2R8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R8 36
  • 99.57 (n)
  • 99.03 (a)
TAS2R8 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R8 36
  • 77.7 (n)
  • 62.95 (a)
mouse
(Mus musculus)
Mammalia Tas2r122 37
  • 34 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 47 (a)
ManyToMany
T2R7A 37
  • 45 (a)
ManyToMany
T2R7B 37
  • 50 (a)
ManyToMany
Species with no ortholog for TAS2R8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R8 Gene

ENSEMBL:
Gene Tree for TAS2R8 (if available)
TreeFam:
Gene Tree for TAS2R8 (if available)

Paralogs for TAS2R8 Gene

Pseudogenes.org Pseudogenes for TAS2R8 Gene

genes like me logo Genes that share paralogs with TAS2R8: view

Variants for TAS2R8 Gene

Sequence variations from dbSNP and Humsavar for TAS2R8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs40313 -- 10,807,378(+) AGTCA(C/T)AAAAA upstream-variant-2KB
rs655046 -- 10,807,701(+) CAGGT(A/G)AAGAT upstream-variant-2KB
rs667123 -- 10,808,178(+) AATAC(A/G)AATCA upstream-variant-2KB
rs667128 -- 10,808,575(+) TTATA(C/T)TCCTT upstream-variant-2KB
rs1548803 -- 10,806,432(+) AGAGT(C/T)AAGGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TAS2R8 Gene

Variant ID Type Subtype PubMed ID
nsv898776 CNV Loss 21882294

Relevant External Links for TAS2R8 Gene

HapMap Linkage Disequilibrium report
TAS2R8

Disorders for TAS2R8 Gene

No disorders were found for TAS2R8 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R8 Gene

Publications for TAS2R8 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R8 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TAS2R8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R8
    • Block miRNA regulation of TAS2R8 using miScript Target Protectors

    Sources for TAS2R8 Gene

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