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Aliases for TAS2R8 Gene

Aliases for TAS2R8 Gene

  • Taste 2 Receptor Member 8 2 3 5
  • Taste Receptor, Type 2, Member 8 2 3
  • Taste Receptor Family B Member 5 3 4
  • T2R8 3 4
  • TRB5 3 4
  • Taste Receptor, Family B, Member 5 3

External Ids for TAS2R8 Gene

Previous GeneCards Identifiers for TAS2R8 Gene

  • GC12M010662
  • GC12M011102
  • GC12M010858
  • GC12M010849
  • GC12M010971
  • GC12M010807

Summaries for TAS2R8 Gene

Entrez Gene Summary for TAS2R8 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R8 Gene

TAS2R8 (Taste 2 Receptor Member 8) is a Protein Coding gene. Among its related pathways are Taste transduction and Sweet Taste Signaling. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R8 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R8 Gene

Genomics for TAS2R8 Gene

Regulatory Elements for TAS2R8 Gene

Enhancers for TAS2R8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R8 Gene

Chromosome:
12
Start:
10,806,051 bp from pter
End:
10,807,293 bp from pter
Size:
1,243 bases
Orientation:
Minus strand

Genomic View for TAS2R8 Gene

Genes around TAS2R8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R8 Gene

Proteins for TAS2R8 Gene

  • Protein details for TAS2R8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW2-TA2R8_HUMAN
    Recommended name:
    Taste receptor type 2 member 8
    Protein Accession:
    Q9NYW2
    Secondary Accessions:
    • Q4KN29
    • Q645Y2

    Protein attributes for TAS2R8 Gene

    Size:
    309 amino acids
    Molecular mass:
    35877 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R8 Gene

Proteomics data for TAS2R8 Gene at MOPED

Post-translational modifications for TAS2R8 Gene

  • Glycosylation at Asn 167
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R8 Gene

Domains & Families for TAS2R8 Gene

Gene Families for TAS2R8 Gene

Protein Domains for TAS2R8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW2

UniProtKB/Swiss-Prot:

TA2R8_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R8: view

Function for TAS2R8 Gene

Molecular function for TAS2R8 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008527 taste receptor activity TAS 10761934
genes like me logo Genes that share ontologies with TAS2R8: view

Phenotypes for TAS2R8 Gene

genes like me logo Genes that share phenotypes with TAS2R8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R8 Gene

Localization for TAS2R8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R8 Gene COMPARTMENTS Subcellular localization image for TAS2R8 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R8 Gene

Pathways & Interactions for TAS2R8 Gene

genes like me logo Genes that share pathways with TAS2R8: view

Pathways by source for TAS2R8 Gene

Interacting Proteins for TAS2R8 Gene

Gene Ontology (GO) - Biological Process for TAS2R8 Gene

None

No data available for SIGNOR curated interactions for TAS2R8 Gene

Drugs & Compounds for TAS2R8 Gene

(2) Drugs for TAS2R8 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma 6
Parthenolide Pharma 4

(1) Additional Compounds for TAS2R8 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
denatonium benzoate
3734-33-6
genes like me logo Genes that share compounds with TAS2R8: view

Transcripts for TAS2R8 Gene

mRNA/cDNA for TAS2R8 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R8 Gene

Taste receptor, type 2, member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R8 Gene

No ASD Table

Relevant External Links for TAS2R8 Gene

GeneLoc Exon Structure for
TAS2R8
ECgene alternative splicing isoforms for
TAS2R8

Expression for TAS2R8 Gene

mRNA expression in normal human tissues for TAS2R8 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R8 Gene

This gene is overexpressed in Brain - Cerebellum (x5.9), Brain - Cortex (x5.2), and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for TAS2R8 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAS2R8 Gene



SOURCE GeneReport for Unigene cluster for TAS2R8 Gene Hs.533755

mRNA Expression by UniProt/SwissProt for TAS2R8 Gene

Q9NYW2-TA2R8_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R8: view

Protein tissue co-expression partners for TAS2R8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TAS2R8 Gene

Orthologs for TAS2R8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TAS2R8 35
  • 77.7 (n)
  • 62.95 (a)
chimpanzee
(Pan troglodytes)
Mammalia TAS2R8 35
  • 99.57 (n)
  • 99.03 (a)
TAS2R8 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
T2R7A 36
  • 45 (a)
ManyToMany
T2R7B 36
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r122 36
  • 34 (a)
ManyToMany
Species with no ortholog for TAS2R8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R8 Gene

ENSEMBL:
Gene Tree for TAS2R8 (if available)
TreeFam:
Gene Tree for TAS2R8 (if available)

Paralogs for TAS2R8 Gene

Pseudogenes.org Pseudogenes for TAS2R8 Gene

genes like me logo Genes that share paralogs with TAS2R8: view

Variants for TAS2R8 Gene

Sequence variations from dbSNP and Humsavar for TAS2R8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_024186 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R8 Gene

Variant ID Type Subtype PubMed ID
nsv898776 CNV Loss 21882294

Variation tolerance for TAS2R8 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R8 Gene

HapMap Linkage Disequilibrium report
TAS2R8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R8 Gene

Disorders for TAS2R8 Gene

Relevant External Links for TAS2R8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R8

No disorders were found for TAS2R8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R8 Gene

Publications for TAS2R8 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4 67
  2. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  3. Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides. (PMID: 21670512) Ueno Y. … Misaka T. (Biosci. Biotechnol. Biochem. 2011) 3
  4. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TAS2R8 Gene

Sources for TAS2R8 Gene

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