TAS2R7 Gene
protein-coding GIFtS: 48
GCID: GC12M010854
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taste receptor, type 2, member 7
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Aliases
for TAS2R7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 2, Member 71 2 | | T2R71 2 3 5 | | TRB41 2 3 5 | | Taste Receptor Family B Member 42 3 | | Taste Receptor Type 2 Member 72 | | Taste Receptor, Family B, Member 42 |
Export aliases for TAS2R7 gene to outside databasesPrevious GC identifers: GC12M010658 GC12M011098 GC12M010845 |
Summaries
for TAS2R7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R7:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptorsuperfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia.They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception inmice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the tastereceptor gene cluster on chromosome 12p13. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TA2R7_HUMAN, Q9NYW3Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and thegastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Gene Wiki entry for TAS2R7
|
Genomic Views
for TAS2R7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R7 gene promoter:
STAT5B GCNF C/EBPalpha RORalpha1 PPAR-gamma1 Nkx6-1 GCNF-1 Chx10 PPAR-gamma2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13TAS2R7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010854: view genomic region
(about GC identifiers)
Start:
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10,954,131 bp from pter |
End:
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10,955,226 bp from pter |
Size:
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1,096 bases |
Orientation:
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minus strand |
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Proteins
for TAS2R7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TA2R7_HUMAN, Q9NYW3 (See
protein sequence)Recommended Name: Taste receptor type 2 member 7 Size: 318 amino acids; 36550 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell
Secondary accessions: Q645Y1Explore the universe of human proteins at neXtProt for TAS2R7: NX_Q9NYW3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYW3
TAS2R7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076408.1
ENSEMBL proteins: ENSP00000240687
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
NAS | -- |
TAS2R7 for ontologies About GeneDecksing
TAS2R7 Antibody Products:
Assay Products for TAS2R7: |
Protein
Domains /
Families
for TAS2R7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYW3ProtoNet protein and cluster: Q9NYW3 UniProtKB/Swiss-Prot: TA2R7_HUMAN, Q9NYW3Similarity: Belongs to the G-protein coupled receptor T2R family |
Function
for TAS2R7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TA2R7_HUMAN, Q9NYW3Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and thegastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TAS2R7 for ontologies About GeneDecksing
|
Pathways & Interactions
for TAS2R7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Taste transduction | | | 2 | Sweet Taste Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R7
1 
Kegg Pathway (Kegg details for TAS2R7):
TAS2R7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R7
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TAS2R7 (ENSP000002406874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0050912 | detection of chemical stimulus involved in sensory perception of taste |
TAS | 10761934 |
TAS2R7 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS2R7
1 HMDB Compound for TAS2R7 About this table
6 BitterDB Bitter Compounds for TAS2R7
| Compound | SMILES |
CAS
# |
|---|
| Caffeine | CN1C(=O)N(C)c2ncn(C)c2C1=O | 58-08-2 | | Chlorpheniramine | CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2 | -- | | cromolyn | OC(COc1ccc2OC(=CC(=O)c2c1)C(=O)O)COc3cccc4OC(=CC(=O)c34)C(=O)O | -- | | diphenidol | OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3 | -- | | Papaverine | COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC | -- | | Quinine | COc1ccc2nccc([C@@H](O)[C@@H]3CC4CCN3C[C@@H]4C=C)c2c1 | -- |
About this table
Search CenterWatch for drugs/clinical trials and news about TAS2R7 / TA2R7
|
Transcripts
for TAS2R7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS2R7 gene: NM_023919.2 Unigene Cluster for TAS2R7: Taste receptor, type 2, member 7 Hs.533754 [show with all ESTs]Unigene Representative Sequence: BC0939921 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000240687(uc001qyv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS2R7 (NM_023919) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R7 |
Additional cDNA sequence: BC069091.1 BC093992.1 BC113561.1 1 DOTS entry: DT.91652806 4 AceView cDNA sequences: CN840760 NM_023919 BC069091 CN840854
GeneLoc Exon Structure
|
Expression
for TAS2R7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS2R7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATCTCTAAA
About this image
See TAS2R7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS2R7
SOURCE GeneReport for Unigene cluster: Hs.533754
UniProtKB/Swiss-Prot: TA2R7_HUMAN, Q9NYW3Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively ingustducin-positive cells
SABiosciences Custom PCR Arrays for TAS2R7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R7 |
Orthologs
for TAS2R7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAS2R7 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for TAS2R7 (if available)
TreeFam Gene Tree for TAS2R7 (if available) |
Paralogs
for TAS2R7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAS2R7 gene
- TAS2R52 TAS2R412 TAS2R462 TAS2R162 TAS2R32 TAS2R142 TAS2R432 TAS2R392
- TAS2R382 TAS2R422 TAS2R92 TAS2R42 TAS2R302 TAS2R12 TAS2R192 TAS2R202
- TAS2R82 TAS2R132 TAS2R402 TAS2R102 TAS2R502 TAS2R602 TAS2R312
18/67 SIMAP similar genes for TAS2R7 using alignment to 1 protein entry: TA2R7_HUMAN(see all similar genes):Hosa(Adygei)-T2R7 Hosa(Biaka)-T2R7 Hosa(Biaka)-T2R8 Hosa(Japanese)-T2R8 TAS2R8 TAS2R9
Hosa(Adygei)-T2R10 Hosa(Biaka)-T2R10 Hosa(Japanese)-T2R10 TAS2R10 Hosa(Adygei)-T2R3 Hosa(Biaka)-T2R3
TAS2R3 Hosa(Biaka)-T2R13 Hosa(Japanese)-T2R13 Hosa(Biaka)-T2R48 Hosa(Japanese)-T2R48 TAS2R13
TAS2R7 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for TAS2R7 (see all 6)
PGOHUM00000239334 PGOHUM00000239345 PGOHUM00000239347 PGOHUM00000233131 PGOHUM00000262528
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Genomic Variants
for TAS2R7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAS2R7 (10954131 - 10955226 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAS2R7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R7 |
|
Disorders
/ Diseases
for TAS2R7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TAS2R7 for disorders About MalaCards
TAS2R7 for disorders About GeneDecksing
OMIM gene information: 604793
OMIM disorders: --
Export disorders for TAS2R7 gene to outside databases
|
Publications
for TAS2R7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS2R7 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TAS2R7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- A family of candidate taste receptors in human and mo use. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (2000)
- T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)
- Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TAS2R7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS2R7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS2R7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAS2R7 gene:
Search GeneIP for patents involving TAS2R7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TAS2R7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R7 |
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