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TAS2R60 Gene

protein-coding   GIFtS: 40
GCID: GC07P143143

Taste Receptor, Type 2, Member 60

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 2, Member 601 2
T2R602 3 5
Taste Receptor Type 2 Member 562 3
T2R562 3
Taste Receptor Type 2 Member 602

External Ids:    HGNC: 206391   Entrez Gene: 3383982   Ensembl: ENSG000001858997   OMIM: 6139685   UniProtKB: P595513   

Export aliases for TAS2R60 gene to outside databases

Previous GC identifers: GC07U900006 GC07P142534 GC07P142611 GC07P142657 GC07P142850 GC07P137477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAS2R60 Gene:
TAS2R60 (taste receptor, type 2, member 60) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R60 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R60 gene promoter:
         AML1a   p300   ATF-2   MIF-1   LCR-F1   Evi-1   FAC1   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R60 promoter sequence
   Search Chromatin IP Primers for TAS2R60

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC chromosome: 7

TAS2R60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R60 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143143:  view genomic region     (about GC identifiers)

Start:
143,140,546 bp from pter      End:
143,141,502 bp from pter
Size:
957 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,542,642-142,543,598     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551 (See protein sequence)
Recommended Name: Taste receptor type 2 member 60  
Size: 318 amino acids; 36337 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: A4D2G8 Q645W8 Q7RTR7

Explore the universe of human proteins at neXtProt for TAS2R60: NX_P59551

Explore proteomics data for TAS2R60 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn179

  • See TAS2R60 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_803186.1  
    ENSEMBL proteins: 
     ENSP00000327724  
    Reactome Protein details: P59551

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R60
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59551

    ProtoNet protein and cluster: P59551

    UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551
    Similarity: Belongs to the G-protein coupled receptor T2R family


    Find genes that share domains with TAS2R60           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R60_HUMAN, P59551
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity NAS12584440
         
    Find genes that share ontologies with TAS2R60           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2R60_HUMAN, P59551: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TAS2R60           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS2R60 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44


    Find genes that share SuperPaths with TAS2R60           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for TAS2R60
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R60):
        Taste transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R60
    Interactions:

        Search GeneGlobe Interaction Network for TAS2R60

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TAS2R60 (ENSP000003277244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAT3ENSP000003813394STRING: ENSP00000381339
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050909sensory perception of taste ----
    GO:0050913sensory perception of bitter taste NAS12584440

    Find genes that share ontologies with TAS2R60           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS2R60 (T2R60)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAS2R60 gene: 
    NM_177437.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332690(uc011ktg.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat TAS2R60

    1 AceView cDNA sequence:

    NM_177437 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAS2R60 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTCATCT
    TAS2R60 Expression
    About this image


    TAS2R60 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    TAS2R60 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS2R60 Protein Expression

    UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAS2R60 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1351 , 5 taste receptor, type 2, member 1351, 5 71.97(n)1
    58.77(a)1
      6 (20.71 cM)5
    3875121  NM_199159.11  NP_954610.11 
     424055295 
    chicken
    (Gallus gallus)
    Aves TAS2R76
    Gallus gallus taste receptor, type 2, member 7 (TA...
    24(a)
    1 → many
    3(109476673-109477638)


    ENSEMBL Gene Tree for TAS2R60 (if available)
    TreeFam Gene Tree for TAS2R60 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS2R60 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
    TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  
    TAS2R202  TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R312  
    Selected SIMAP similar genes for TAS2R60 using alignment to 1 protein entry:     T2R60_HUMAN(see all similar genes):
    Hosa(Japanese)-T2R56    TAS2R41    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R16    Hosa(Biaka)-T2R7    Hosa(Japanese)-T2R16
    TAS2R16    Hosa(Adygei)-T2R3    Hosa(Biaka)-T2R3    TAS2R3    TAS2R7    TAS2R9
    Hosa(Biaka)-T2R40    Hosa(Japanese)-T2R40    TAS2R13    TAS2R40    Hosa(Japanese)-T2R39    TAS2R39

    Find genes that share paralogs with TAS2R60           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAS2R60
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R60

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613968    OMIM disorders: --


    Find genes that share disorders with TAS2R60           About GenesLikeMe


    Export disorders for TAS2R60 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS2R60 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TAS2R60)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (Cytogenet. Genome Res. 2002)
    2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (Cell 2003)
    6. Adaptive diversification of bitter taste receptor genes in mammalian evolution. (PubMed id 12679530)1, 2 Shi P.... Zhang Y.-P. (Mol. Biol. Evol. 2003)
    7. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (J. Biol. Chem. 2002)
    8. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)
    9. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (Genetics 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 338398 HGNC: 20639 AceView: TAS2R60 Ensembl:ENSG00000185899 euGenes: HUgn338398
    ECgene: TAS2R60 Kegg: 338398 H-InvDB: TAS2R60

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS2R60 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAS2R60 gene:
    Search GeneIP for patents involving TAS2R60

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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