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Aliases for TAS2R60 Gene

Aliases for TAS2R60 Gene

  • Taste 2 Receptor Member 60 2 3 5
  • Taste Receptor, Type 2, Member 60 2 3
  • Taste Receptor Type 2 Member 56 3 4
  • T2R56 3 4
  • T2R60 3 4
  • Taste Receptor Type 2 Member 60 3

External Ids for TAS2R60 Gene

Previous GeneCards Identifiers for TAS2R60 Gene

  • GC07U900006
  • GC07P142534
  • GC07P142611
  • GC07P142657
  • GC07P142850
  • GC07P143143
  • GC07P137477

Summaries for TAS2R60 Gene

GeneCards Summary for TAS2R60 Gene

TAS2R60 (Taste 2 Receptor Member 60) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot for TAS2R60 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R60 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R60 Gene

Genomics for TAS2R60 Gene

Regulatory Elements for TAS2R60 Gene

Enhancers for TAS2R60 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143378 1.8 FANTOM5 Ensembl ENCODE 5.1 -57.3 -57259 15.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZYX EPHA1-AS1 EPHA1 CLCN1 HINT1P1 OR2A1 FAM131B LOC100507507 TAS2R60 ARHGEF35
GH07F143484 0.8 Ensembl ENCODE 8.8 +41.6 41617 1.9 JUND CEBPB KDM1A MNT SPI1 TAS2R60 LOC154761 OR2R1P TAS2R41
GH07F143512 0.7 Ensembl ENCODE 8.6 +69.3 69259 1.3 JUND HINFP FOS TAS2R60 EPHA1 ARHGEF35 OR10AC1 GC07M143535
GH07F143394 1.2 Ensembl ENCODE 5 -47.9 -47853 1.6 ELF3 TBP ARID4B THRB ZNF48 RAD21 RARA YY1 THAP11 MCM3 ZYX TAS2R60 EPHA1-AS1 MIR6892
GH07F143511 0.4 Ensembl 8.6 +68.0 68048 0.6 ZBTB33 MGA TAS2R60 OR10AC1 LOC105375547
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R60 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R60 Gene

Chromosome:
7
Start:
143,443,453 bp from pter
End:
143,444,409 bp from pter
Size:
957 bases
Orientation:
Plus strand

Genomic View for TAS2R60 Gene

Genes around TAS2R60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R60 Gene

Proteins for TAS2R60 Gene

  • Protein details for TAS2R60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59551-T2R60_HUMAN
    Recommended name:
    Taste receptor type 2 member 60
    Protein Accession:
    P59551
    Secondary Accessions:
    • A4D2G8
    • Q645W8
    • Q7RTR7

    Protein attributes for TAS2R60 Gene

    Size:
    318 amino acids
    Molecular mass:
    36337 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R60 Gene

Post-translational modifications for TAS2R60 Gene

  • Glycosylation at Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R60 Gene

Domains & Families for TAS2R60 Gene

Gene Families for TAS2R60 Gene

Protein Domains for TAS2R60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59551

UniProtKB/Swiss-Prot:

T2R60_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R60: view

Function for TAS2R60 Gene

Molecular function for TAS2R60 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity NAS 12584440
GO:0033038 NOT bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R60: view
genes like me logo Genes that share phenotypes with TAS2R60: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R60 Gene

Localization for TAS2R60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R60 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R60 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 20022913
genes like me logo Genes that share ontologies with TAS2R60: view

Pathways & Interactions for TAS2R60 Gene

genes like me logo Genes that share pathways with TAS2R60: view

Pathways by source for TAS2R60 Gene

Gene Ontology (GO) - Biological Process for TAS2R60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 NOT detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R60: view

No data available for SIGNOR curated interactions for TAS2R60 Gene

Transcripts for TAS2R60 Gene

mRNA/cDNA for TAS2R60 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R60 Gene

No ASD Table

Relevant External Links for TAS2R60 Gene

GeneLoc Exon Structure for
TAS2R60
ECgene alternative splicing isoforms for
TAS2R60

Expression for TAS2R60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R60 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R60 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAS2R60 Gene:

TAS2R60

SOURCE GeneReport for Unigene cluster for TAS2R60 Gene:

Hs.688222

mRNA Expression by UniProt/SwissProt for TAS2R60 Gene:

P59551-T2R60_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R60: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TAS2R60 Gene

Orthologs for TAS2R60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R60 34 35
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia TAS2R60 34
  • 75.87 (n)
mouse
(Mus musculus)
Mammalia Tas2r135 34 16 35
  • 71.97 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r135 34
  • 71.27 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R56 35
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAFA-T2R2 35
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TAS2R7 35
  • 24 (a)
OneToMany
Species where no ortholog for TAS2R60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R60 Gene

ENSEMBL:
Gene Tree for TAS2R60 (if available)
TreeFam:
Gene Tree for TAS2R60 (if available)

Paralogs for TAS2R60 Gene

Variants for TAS2R60 Gene

Sequence variations from dbSNP and Humsavar for TAS2R60 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10241042 -- 143,442,717(+) ATATC(C/G)CATTG intron-variant, upstream-variant-2KB
rs10241523 -- 143,443,179(+) ATTAT(A/C)CACTT intron-variant, upstream-variant-2KB
rs112054197 -- 143,444,128(+) GGAAG(A/G)AGGCT intron-variant, reference, missense
rs112507061 -- 143,444,434(+) TTCAA(C/G)GAGAT intron-variant, downstream-variant-500B
rs113956572 -- 143,444,775(+) TCAAT(C/T)GAACT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TAS2R60 Gene

Variant ID Type Subtype PubMed ID
nsv608682 CNV gain 21841781

Variation tolerance for TAS2R60 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R60 Gene

Disorders for TAS2R60 Gene

Relevant External Links for TAS2R60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R60

No disorders were found for TAS2R60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R60 Gene

Publications for TAS2R60 Gene

  1. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PMID: 12584440) Conte C. … Andres-Barquin P.J. (Cytogenet. Genome Res. 2002) 2 3 4 64
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
  5. Adaptive diversification of bitter taste receptor genes in mammalian evolution. (PMID: 12679530) Shi P. … Zhang Y.-P. (Mol. Biol. Evol. 2003) 3 4 64

Products for TAS2R60 Gene

Sources for TAS2R60 Gene

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