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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R60 Gene

protein-coding   GIFtS: 42
GCID: GC07P143143

Taste Receptor, Type 2, Member 60

  Search for TAS2R60
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 601 2
Taste Receptor Type 2 Member 562 3
T2R562 3
T2R602 3
Taste Receptor Type 2 Member 602

External Ids:    HGNC: 206391   Entrez Gene: 3383982   Ensembl: ENSG000001858997   OMIM: 6139685   UniProtKB: P595513   

Export aliases for TAS2R60 gene to outside databases

Previous GC identifers: GC07U900006 GC07P142534 GC07P142611 GC07P142657 GC07P142850 GC07P137477


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TAS2R60 Gene: 
TAS2R60 (taste receptor, type 2, member 60) is a protein-coding gene. Among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R60 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R60 gene promoter:
         AML1a   p300   ATF-2   MIF-1   LCR-F1   Evi-1   FAC1   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R60 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R60

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC chromosome: 7

TAS2R60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R60 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143143:  view genomic region     (about GC identifiers)

Start:
143,140,546 bp from pter      End:
143,141,502 bp from pter
Size:
957 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,542,642-142,543,598     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551 (See protein sequence)
Recommended Name: Taste receptor type 2 member 60  
Size: 318 amino acids; 36337 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: A4D2G8 Q645W8 Q7RTR7

Explore the universe of human proteins at neXtProt for TAS2R60: NX_P59551

Explore proteomics data for TAS2R60 at MOPED 

TAS2R60 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TAS2R60 Protein Expression

REFSEQ proteins: NP_803186.1  
ENSEMBL proteins: 
 ENSP00000327724  
Reactome Protein details: P59551
Human Recombinant Protein Products for TAS2R60: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

TAS2R60 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TASNR: GPCR / Unclassified : Taste receptors
TAS2R: Taste receptors / Type 2

IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R60 
Taste 2 receptors

1 InterPro protein domain:
 IPR007960 TAS2_rcpt

Graphical View of Domain Structure for InterPro Entry P59551

ProtoNet protein and cluster: P59551

UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551
Similarity: Belongs to the G-protein coupled receptor T2R family


TAS2R60 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T2R60_HUMAN, P59551
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity NAS12584440
     
TAS2R60 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TAS2R60 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
Taste transduction0.45
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71
G alpha (i) signalling events0.46

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/6        Reactome Pathways for TAS2R60 (see all 6)
    GPCR downstream signaling
Signal Transduction
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by GPCR
G alpha (i) signalling events


1         Kegg Pathway  (Kegg details for TAS2R60):
    Taste transduction


TAS2R60 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R60

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TAS2R60 (ENSP000003277244) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GNAT3ENSP000003813394STRING: ENSP00000381339
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0050909sensory perception of taste ----
GO:0050913sensory perception of bitter taste NAS12584440

TAS2R60 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS2R60 (T2R60)

Search CenterWatch for drugs/clinical trials and news about TAS2R60 / T2R60

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAS2R60 gene: 
NM_177437.1  

Unigene Cluster for TAS2R60:

Taste receptor, type 2, member 60
Hs.688222
Unigene Representative Sequence: NM_177437
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000332690(uc011ktg.2)
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Additional mRNA sequence: 

BC100938.2 BC100939.2 BC100940.1 BC100941.1 

1 DOTS entry:

DT.100702952 

1 AceView cDNA sequence:

NM_177437 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAS2R60 expression in normal human tissues (normalized intensities)      TAS2R60 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCTTCATCT
TAS2R60 Expression
About this image


TAS2R60 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Heart (Cardiovascular System)
         Cardiac Fibroblasts Myocardium

See TAS2R60 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.688222

UniProtKB/Swiss-Prot: T2R60_HUMAN, P59551
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
gustducin-positive cells

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R60 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tas2r1351 , 5 taste receptor, type 2, member 1351, 5 71.97(n)1
58.77(a)1
  6 (20.71 cM)5
3875121  NM_199159.11  NP_954610.11 
 424055295 
chicken
(Gallus gallus)
Aves TAS2R76
taste receptor type 2 member 7
24(a)
possible ortholog
3(109476673-109477638)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Taste receptor type 2
(see all 3)
41(a)
26(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343381.1(254214-512591)
GL343391.1(165866-166828)
zebrafish
(Danio rerio)
Actinopterygii tas2r200.16
tas2r200.26
taste receptor, type 2, member 200.2
13(a)
13(a)
many ↔ many
many ↔ many
8(31631970-31633062)
8(31629027-31630131)


ENSEMBL Gene Tree for TAS2R60 (if available)
TreeFam Gene Tree for TAS2R60 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TAS2R60 gene
TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  
TAS2R202  TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R312  
18/20 SIMAP similar genes for TAS2R60 using alignment to 1 protein entry:     T2R60_HUMAN(see all similar genes):
Hosa(Japanese)-T2R56    TAS2R41    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R16    Hosa(Biaka)-T2R7    Hosa(Japanese)-T2R16
TAS2R16    Hosa(Adygei)-T2R3    Hosa(Biaka)-T2R3    TAS2R3    TAS2R7    TAS2R9
Hosa(Biaka)-T2R40    Hosa(Japanese)-T2R40    TAS2R13    TAS2R40    Hosa(Japanese)-T2R39    TAS2R39

TAS2R60 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TAS2R60
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAS2R60 for disorders           About MalaCards
OMIM gene information: 613968    OMIM disorders: --


TAS2R60 for disorders           About GeneDecksing


Export disorders for TAS2R60 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAS2R60 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAS2R60)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (2002)
  2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
  6. Adaptive diversification of bitter taste receptor genes in mammalian evolution. (PubMed id 12679530)1, 2 Shi P.... Zhang Y.-P. (2003)
  7. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
  8. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
  9. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 338398 HGNC: 20639 AceView: TAS2R60 Ensembl:ENSG00000185899 euGenes: HUgn338398
ECgene: TAS2R60 Kegg: 338398 H-InvDB: TAS2R60

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TAS2R60 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TAS2R60 gene:
Search GeneIP for patents involving TAS2R60

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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