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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R50 Gene

protein-coding   GIFtS: 49
GCID: GC12M011138

Taste Receptor, Type 2, Member 50

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 501 2
T2R502 3 5
T2R512 3 5
Taste Receptor Type 2 Member 512 3
TAS2R512 5
Taste Receptor Type 2 Member 502

External Ids:    HGNC: 188821   Entrez Gene: 2592962   Ensembl: ENSG000002121267   OMIM: 6096275   UniProtKB: P595443   

Export aliases for TAS2R50 gene to outside databases

Previous GC identifers: GC00U991259 GC12M011038 GC12M011029 GC12M010866


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R50 Gene:
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells
and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002
(PubMed 12584440)). See also TAS2R10 (MIM 604791).(supplied by OMIM, Mar 2008)

GeneCards Summary for TAS2R50 Gene: 
TAS2R50 (taste receptor, type 2, member 50) is a protein-coding gene. Diseases associated with TAS2R50 include myocardial infarction, and among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R50 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R50 gene promoter:
         FOXO3   POU6F1 (c2)   FOXO3b   POU2F1   FOXO4   POU2F1a   POU2F1b   FOXO3a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R50 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R50

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R50


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

TAS2R50 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R50 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011138:  view genomic region     (about GC identifiers)

Start:
11,138,512 bp from pter      End:
11,139,511 bp from pter
Size:
1,000 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571050 184,619-185,618      Chr12-,NW_003571047 184,619-185,618     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544 (See protein sequence)
Recommended Name: Taste receptor type 2 member 50  
Size: 299 amino acids; 34558 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: P59545 Q2M255 Q645Y0

Explore the universe of human proteins at neXtProt for TAS2R50: NX_P59544

Explore proteomics data for TAS2R50 at MOPED 

TAS2R50 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TAS2R50 Protein Expression

REFSEQ proteins: NP_795371.2  
ENSEMBL proteins: 
 ENSP00000424040  
Reactome Protein details: P59544
Human Recombinant Protein Products for TAS2R50: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

TAS2R50 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TASNR: GPCR / Unclassified : Taste receptors
TAS2R: Taste receptors / Type 2

IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R50 
Taste 2 receptors

1 InterPro protein domain:
 IPR007960 TAS2_rcpt

Graphical View of Domain Structure for InterPro Entry P59544

ProtoNet protein and cluster: P59544

UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544
Similarity: Belongs to the G-protein coupled receptor T2R family


TAS2R50 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T2R50_HUMAN, P59544
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
TAS2R50 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TAS2R50 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
Taste transduction0.45
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71
G alpha (i) signalling events0.46

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/6        Reactome Pathways for TAS2R50 (see all 6)
    GPCR downstream signaling
Signal Transduction
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by GPCR
G alpha (i) signalling events


1         Kegg Pathway  (Kegg details for TAS2R50):
    Taste transduction


TAS2R50 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R50

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0050909sensory perception of taste IEA--

TAS2R50 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS2R50 (T2R50)

2 BitterDB Bitter Compounds for TAS2R50 About this table
CompoundSMILES CAS #
amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
andrographolideC[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](CC=C3/[C@H](O)COC3=O)C(=C)CC[C@H]125508-58-7


Search CenterWatch for drugs/clinical trials and news about TAS2R50 / T2R50

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAS2R50 gene: 
NM_176890.2  

Unigene Cluster for TAS2R50:

Taste receptor, type 2, member 50
Hs.688194
Unigene Representative Sequence: NM_176890
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000506868(uc001qzl.2)
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R50

Additional mRNA sequence: BC112100.1 

1 DOTS entry:

DT.100702958 

1 AceView cDNA sequence:

NM_176890 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAS2R50 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAAGGATC
TAS2R50 Expression
About this image


See TAS2R50 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS2R50

SOURCE GeneReport for Unigene cluster: Hs.688194

UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
gustducin-positive cells

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R50
In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for TAS2R50 (if available)
TreeFam Gene Tree for TAS2R50 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TAS2R50 gene
TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  
TAS2R202  TAS2R82  TAS2R102  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
18/48 SIMAP similar genes for TAS2R50 using alignment to 1 protein entry:     T2R50_HUMAN(see all similar genes):
Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R50    Hosa(Biaka)-T2R47    TAS2R30    Hosa(Adygei)-T2R46
Hosa(Biaka)-T2R46    Hosa(Biaka)-T2R48    Hosa(Japanese)-T2R45    Hosa(Japanese)-T2R48    TAS2R46    TAS2R45
Hosa(Biaka)-T2R43    TAS2R19    TAS2R31    TAS2R43    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R49

TAS2R50 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

1 SNPs in TAS2R50 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0241874
----see VAR_0241872 C Y mis40--------

HapMap Linkage Disequilibrium report for TAS2R50 (11138512 - 11139511 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for TAS2R50:    About this table     
Variant IDTypeSubtypePubMed ID
esv2745546CNV Deletion23290073
nsv898779CNV Loss21882294
nsv898778CNV Loss21882294
nsv832330CNV Gain17160897
nsv428272CNV Gain+Loss18775914
essv11102CNV CNV17122850
dgv476e1CNV Complex17122850
dgv475e1CNV Complex17122850


Human Gene Mutation Database (HGMD): TAS2R50
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TAS2R50
DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R50

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609627    OMIM disorders: --

2 diseases for TAS2R50:    About MalaCards
myocardial infarction    


TAS2R50 for disorders           About GeneDecksing

Genetic Association Database (GAD): TAS2R50
Human Genome Epidemiology (HuGE) Navigator: TAS2R50 (5 documents)

Export disorders for TAS2R50 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAS2R50 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TAS2R50)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)1, 3, 4 Shiffman D.... Kane J.P. (2005)
  2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (2002)
  3. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
  5. Variations of specific non-candidate genes and risk o f myocardial infarction: A replication study. (PubMed id 19709766)1, 4 Koch W....Kastrati A. (2009)
  6. Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. (PubMed id 17967605)1, 4 Horne B.D....Anderson J.L. (2007)
  7. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  9. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
  10. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 259296 HGNC: 18882 AceView: TAS2R50 Ensembl:ENSG00000212126 euGenes: HUgn259296
ECgene: TAS2R50 Kegg: 259296 H-InvDB: TAS2R50

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TAS2R50 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TAS2R50 gene:
Search GeneIP for patents involving TAS2R50

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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