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Aliases for TAS2R50 Gene

Aliases for TAS2R50 Gene

  • Taste 2 Receptor Member 50 2 3 5
  • Taste Receptor, Type 2, Member 50 2 3
  • Taste Receptor Type 2 Member 51 3 4
  • T2R50 3 4
  • T2R51 3 4
  • TAS2R51 3

External Ids for TAS2R50 Gene

Previous GeneCards Identifiers for TAS2R50 Gene

  • GC00U991259
  • GC12M011038
  • GC12M011029
  • GC12M011138
  • GC12M010866

Summaries for TAS2R50 Gene

Entrez Gene Summary for TAS2R50 Gene

  • TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008]

GeneCards Summary for TAS2R50 Gene

TAS2R50 (Taste 2 Receptor Member 50) is a Protein Coding gene. Among its related pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R50 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R50 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R50 Gene

Genomics for TAS2R50 Gene

Regulatory Elements for TAS2R50 Gene

Enhancers for TAS2R50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R50 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R50 Gene

Chromosome:
12
Start:
10,985,913 bp from pter
End:
10,986,912 bp from pter
Size:
1,000 bases
Orientation:
Minus strand

Genomic View for TAS2R50 Gene

Genes around TAS2R50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R50 Gene

Proteins for TAS2R50 Gene

  • Protein details for TAS2R50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59544-T2R50_HUMAN
    Recommended name:
    Taste receptor type 2 member 50
    Protein Accession:
    P59544
    Secondary Accessions:
    • P59545
    • Q2M255
    • Q645Y0

    Protein attributes for TAS2R50 Gene

    Size:
    299 amino acids
    Molecular mass:
    34558 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R50 Gene

Proteomics data for TAS2R50 Gene at MOPED

Post-translational modifications for TAS2R50 Gene

Other Protein References for TAS2R50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R50 Gene

Domains & Families for TAS2R50 Gene

Gene Families for TAS2R50 Gene

Protein Domains for TAS2R50 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59544

UniProtKB/Swiss-Prot:

T2R50_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R50: view

Function for TAS2R50 Gene

Molecular function for TAS2R50 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
genes like me logo Genes that share phenotypes with TAS2R50: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R50 Gene

Localization for TAS2R50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R50 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R50 Gene COMPARTMENTS Subcellular localization image for TAS2R50 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R50 Gene

Pathways & Interactions for TAS2R50 Gene

genes like me logo Genes that share pathways with TAS2R50: view

Pathways by source for TAS2R50 Gene

Interacting Proteins for TAS2R50 Gene

Gene Ontology (GO) - Biological Process for TAS2R50 Gene

None

No data available for SIGNOR curated interactions for TAS2R50 Gene

Drugs & Compounds for TAS2R50 Gene

(1) Drugs for TAS2R50 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Andrographolide Pharma NF-κB signaling Inhibitor, Inhibits NFkappaB; blocks androgen receptor (AR) expression 6

(1) Additional Compounds for TAS2R50 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amarogentin
21018-84-8
genes like me logo Genes that share compounds with TAS2R50: view

Transcripts for TAS2R50 Gene

mRNA/cDNA for TAS2R50 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R50 Gene

No ASD Table

Relevant External Links for TAS2R50 Gene

GeneLoc Exon Structure for
TAS2R50
ECgene alternative splicing isoforms for
TAS2R50

Expression for TAS2R50 Gene

mRNA expression in normal human tissues for TAS2R50 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R50 Gene

This gene is overexpressed in Brain - Cerebellum (x4.2).

SOURCE GeneReport for Unigene cluster for TAS2R50 Gene Hs.688194

mRNA Expression by UniProt/SwissProt for TAS2R50 Gene

P59544-T2R50_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R50 Gene

Orthologs for TAS2R50 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R50 35
  • 99.11 (n)
  • 98.32 (a)
TAS2R50 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
ManyToMany
TAS2R46 36
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 36
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 32 (a)
ManyToMany
T2R24 36
  • 33 (a)
ManyToMany
T2R25 36
  • 32 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r120 36
  • 50 (a)
ManyToMany
Tas2r136 36
  • 41 (a)
ManyToMany
Species with no ortholog for TAS2R50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R50 Gene

ENSEMBL:
Gene Tree for TAS2R50 (if available)
TreeFam:
Gene Tree for TAS2R50 (if available)

Paralogs for TAS2R50 Gene

genes like me logo Genes that share paralogs with TAS2R50: view

Variants for TAS2R50 Gene

Sequence variations from dbSNP and Humsavar for TAS2R50 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_024187 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R50 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897
nsv898778 CNV Loss 21882294
esv2745546 CNV Deletion 23290073
nsv898779 CNV Loss 21882294

Variation tolerance for TAS2R50 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R50 Gene

Human Gene Mutation Database (HGMD)
TAS2R50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R50 Gene

Disorders for TAS2R50 Gene

Relevant External Links for TAS2R50

Genetic Association Database (GAD)
TAS2R50
Human Genome Epidemiology (HuGE) Navigator
TAS2R50
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R50

No disorders were found for TAS2R50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R50 Gene

Publications for TAS2R50 Gene

  1. Identification of four gene variants associated with myocardial infarction. (PMID: 16175505) Shiffman D. … Kane J.P. (Am. J. Hum. Genet. 2005) 2 3 48 67
  2. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3
  3. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PMID: 12584440) Conte C. … Andres-Barquin P.J. (Cytogenet. Genome Res. 2002) 2 3
  4. KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. (PMID: 22192511) Akao H. … Schaefer E.J. (Atherosclerosis 2012) 3
  5. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W. … Kastrati A. (Int. J. Cardiol. 2011) 3

Products for TAS2R50 Gene

Sources for TAS2R50 Gene

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