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TAS2R50 Gene

protein-coding   GIFtS: 47
GCID: GC12M011138

Taste Receptor, Type 2, Member 50

  Search for TAS2R50
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 2, Member 501 2
T2R502 3 5
T2R512 3 5
Taste Receptor Type 2 Member 512 3
TAS2R512 5
Taste Receptor Type 2 Member 502

External Ids:    HGNC: 188821   Entrez Gene: 2592962   Ensembl: ENSG000002121267   OMIM: 6096275   UniProtKB: P595443   

Export aliases for TAS2R50 gene to outside databases

Previous GC identifers: GC00U991259 GC12M011038 GC12M011029 GC12M010866


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAS2R50 Gene:
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells
and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002
(PubMed 12584440)). See also TAS2R10 (MIM 604791).(supplied by OMIM, Mar 2008)

GeneCards Summary for TAS2R50 Gene:
TAS2R50 (taste receptor, type 2, member 50) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R50 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R50 gene promoter:
         FOXO3   POU6F1 (c2)   FOXO3b   POU2F1   FOXO4   POU2F1a   POU2F1b   FOXO3a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R50 promoter sequence
   Search Chromatin IP Primers for TAS2R50

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R50


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

TAS2R50 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R50 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011138:  view genomic region     (about GC identifiers)

Start:
11,138,512 bp from pter      End:
11,139,511 bp from pter
Size:
1,000 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571050 184,619-185,618      Chr12-,NW_003571047 184,619-185,618     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544 (See protein sequence)
Recommended Name: Taste receptor type 2 member 50  
Size: 299 amino acids; 34558 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: P59545 Q2M255 Q645Y0

Explore the universe of human proteins at neXtProt for TAS2R50: NX_P59544

Explore proteomics data for TAS2R50 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn161

  • See TAS2R50 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_795371.2  
    ENSEMBL proteins: 
     ENSP00000424040  
    Reactome Protein details: P59544

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R50
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59544

    ProtoNet protein and cluster: P59544

    UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544
    Similarity: Belongs to the G-protein coupled receptor T2R family


    Find genes that share domains with TAS2R50           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R50_HUMAN, P59544
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with TAS2R50           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2R50_HUMAN, P59544: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TAS2R50           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS2R50 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44


    Find genes that share SuperPaths with TAS2R50           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for TAS2R50
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R50):
        Taste transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R50
    Interactions:

        Search GeneGlobe Interaction Network for TAS2R50

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050909sensory perception of taste IEA--

    Find genes that share ontologies with TAS2R50           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS2R50 (T2R50)

    2 BitterDB Bitter Compounds for TAS2R50    About this table
    CompoundSMILES CAS #
    amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
    andrographolideC[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](CC=C3/[C@H](O)COC3=O)C(=C)CC[C@H]125508-58-7




    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAS2R50 gene: 
    NM_176890.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000506868(uc001qzl.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat TAS2R50

    1 AceView cDNA sequence:

    NM_176890 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAS2R50 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGGATC
    TAS2R50 Expression
    About this image

    TAS2R50 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS2R50 Protein Expression

    UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for TAS2R50 (if available)
    TreeFam Gene Tree for TAS2R50 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS2R50 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
    TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  
    TAS2R202  TAS2R82  TAS2R102  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    Selected SIMAP similar genes for TAS2R50 using alignment to 1 protein entry:     T2R50_HUMAN(see all similar genes):
    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R50    Hosa(Biaka)-T2R47    TAS2R30    Hosa(Adygei)-T2R46
    Hosa(Biaka)-T2R46    Hosa(Biaka)-T2R48    Hosa(Japanese)-T2R45    Hosa(Japanese)-T2R48    TAS2R46    TAS2R45
    Hosa(Biaka)-T2R43    TAS2R19    TAS2R31    TAS2R43    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R49

    Find genes that share paralogs with TAS2R50           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for TAS2R50    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13762511,2,4
    ----see VAR_0241872 mis40--------

    HapMap Linkage Disequilibrium report for TAS2R50 (11138512 - 11139511 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TAS2R50:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745546CNV Deletion23290073
    nsv898779CNV Loss21882294
    nsv898778CNV Loss21882294
    nsv832330CNV Gain17160897
    nsv428272CNV Gain+Loss18775914
    essv11102CNV CNV17122850
    dgv476e1CNV Complex17122850
    dgv475e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): TAS2R50
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAS2R50
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R50

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609627    OMIM disorders: --


    Find genes that share disorders with TAS2R50           About GenesLikeMe

    Genetic Association Database (GAD): TAS2R50
    Human Genome Epidemiology (HuGE) Navigator: TAS2R50 (5 documents)

    Export disorders for TAS2R50 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS2R50 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TAS2R50)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)1, 3, 4 Shiffman D.... Kane J.P. (Am. J. Hum. Genet. 2005)
    2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (Cytogenet. Genome Res. 2002)
    3. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (Nat. Genet. 2002)
    4. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PubMed id 19709766)1, 4 Koch W....Kastrati A. (Int. J. Cardiol. 2011)
    5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    6. Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. (PubMed id 17967605)1, 4 Horne B.D....Anderson J.L. (Am. Heart J. 2007)
    7. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (Cell 2003)
    10. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 259296 HGNC: 18882 AceView: TAS2R50 Ensembl:ENSG00000212126 euGenes: HUgn259296
    ECgene: TAS2R50 Kegg: 259296 H-InvDB: TAS2R50

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS2R50 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAS2R50 gene:
    Search GeneIP for patents involving TAS2R50

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search Addgene for plasmids for TAS2R50
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