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Aliases for TAS2R5 Gene

Aliases for TAS2R5 Gene

  • Taste 2 Receptor Member 5 2 3 5
  • Taste Receptor, Type 2, Member 5 2 3
  • T2R5 3 4
  • Taste Receptor Type 2 Member 5 3

External Ids for TAS2R5 Gene

Previous GeneCards Identifiers for TAS2R5 Gene

  • GC07P139760
  • GC07P140820
  • GC07P140897
  • GC07P140943
  • GC07P141136
  • GC07P141490
  • GC07P135786
  • GC07P142613
  • GC07P142906
  • GC07P143068
  • GC07P143215
  • GC07P143413

Summaries for TAS2R5 Gene

Entrez Gene Summary for TAS2R5 Gene

  • This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R5 Gene

TAS2R5 (Taste 2 Receptor Member 5) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot for TAS2R5 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R5 Gene

Genomics for TAS2R5 Gene

Regulatory Elements for TAS2R5 Gene

Enhancers for TAS2R5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G141673 1.3 Ensembl ENCODE dbSUPER 38.5 -114.8 -114815 3.8 ZNF493 ZFP64 RAD21 ZNF354C FOS EGR2 ZNF202 ZNF680 ZNF654 ZBTB11 TAS2R6P TAS2R5 WEE2-AS1 PRSS37 ENSG00000270157 KIAA1147 WEE2 TAS2R4 SSBP1 TMEM178B
GH07G141550 1.1 ENCODE 18.8 -238.9 -238894 1.7 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 TAS2R6P TAS2R5 TAS2R4 WEE2 AGK ENSG00000270157 WEE2-AS1 ENSG00000261570 ENSG00000244701
GH07G141736 1.2 ENCODE 11.2 -51.9 -51876 3.1 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 WEE2-AS1 PRSS37 TAS2R6P WEE2 KIAA1147 TAS2R5 TAS2R4 SSBP1
GH07G141662 1.1 ENCODE dbSUPER 10.5 -126.5 -126491 3.0 ELF3 HNRNPUL1 NFIB SIN3A RAD21 YY1 GATA2 FOS ZNF217 MBD2 KIAA1147 WEE2 TAS2R5 ENSG00000270157 ENSG00000244701 WEE2-AS1 PIR48863
GH07G140972 1.1 ENCODE 9.9 -816.9 -816921 1.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 BRAF TMEM178B TAS2R6P NDUFB2-AS1 NDUFB2 TAS2R5 CCT4P1 LOC105375536
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R5 Gene

Chromosome:
7
Start:
141,790,217 bp from pter
End:
141,791,367 bp from pter
Size:
1,151 bases
Orientation:
Plus strand

Genomic View for TAS2R5 Gene

Genes around TAS2R5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R5 Gene

Proteins for TAS2R5 Gene

  • Protein details for TAS2R5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW4-TA2R5_HUMAN
    Recommended name:
    Taste receptor type 2 member 5
    Protein Accession:
    Q9NYW4
    Secondary Accessions:
    • Q645W0
    • Q75MV7

    Protein attributes for TAS2R5 Gene

    Size:
    299 amino acids
    Molecular mass:
    34505 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R5 Gene

Post-translational modifications for TAS2R5 Gene

  • Glycosylation at isoforms=155
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R5 Gene

Domains & Families for TAS2R5 Gene

Gene Families for TAS2R5 Gene

Protein Domains for TAS2R5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW4

UniProtKB/Swiss-Prot:

TA2R5_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R5: view

Function for TAS2R5 Gene

Molecular function for TAS2R5 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R5: view
genes like me logo Genes that share phenotypes with TAS2R5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R5 Gene

Localization for TAS2R5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 10761934
genes like me logo Genes that share ontologies with TAS2R5: view

Pathways & Interactions for TAS2R5 Gene

genes like me logo Genes that share pathways with TAS2R5: view

Pathways by source for TAS2R5 Gene

Gene Ontology (GO) - Biological Process for TAS2R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction TAS 10761934
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007635 chemosensory behavior TAS 10761935
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with TAS2R5: view

No data available for SIGNOR curated interactions for TAS2R5 Gene

Drugs & Compounds for TAS2R5 Gene

(1) Drugs for TAS2R5 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,10-phenanthroline Experimental Pharma 0
genes like me logo Genes that share compounds with TAS2R5: view

Transcripts for TAS2R5 Gene

mRNA/cDNA for TAS2R5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R5 Gene

Taste receptor, type 2, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R5 Gene

No ASD Table

Relevant External Links for TAS2R5 Gene

GeneLoc Exon Structure for
TAS2R5
ECgene alternative splicing isoforms for
TAS2R5

Expression for TAS2R5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R5 Gene:

TAS2R5

SOURCE GeneReport for Unigene cluster for TAS2R5 Gene:

Hs.675370

mRNA Expression by UniProt/SwissProt for TAS2R5 Gene:

Q9NYW4-TA2R5_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Evidence on tissue expression from TISSUES for TAS2R5 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TAS2R5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R5 Gene

Orthologs for TAS2R5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R5 34 35
  • 98.55 (n)
dog
(Canis familiaris)
Mammalia TAS2R5 34 35
  • 85.5 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R2 35
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r143 35
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TAS2R7 35
  • 22 (a)
OneToMany
Species where no ortholog for TAS2R5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R5 Gene

ENSEMBL:
Gene Tree for TAS2R5 (if available)
TreeFam:
Gene Tree for TAS2R5 (if available)

Paralogs for TAS2R5 Gene

genes like me logo Genes that share paralogs with TAS2R5: view

Variants for TAS2R5 Gene

Sequence variations from dbSNP and Humsavar for TAS2R5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000251882 -- 141,788,353(+) TTCCA(C/G)TTGTC upstream-variant-2KB
rs1000596029 -- 141,789,859(+) GGTCT(C/T)GAACT upstream-variant-2KB
rs1000738197 -- 141,790,092(+) CCAAA(A/G)CCTTT upstream-variant-2KB
rs1001956582 -- 141,790,461(+) TTAGA(C/G)AATGG reference, missense
rs1003365437 -- 141,791,802(+) CTTTA(C/T)ATTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TAS2R5 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310

Variation tolerance for TAS2R5 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R5 Gene

Disorders for TAS2R5 Gene

Relevant External Links for TAS2R5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R5

No disorders were found for TAS2R5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R5 Gene

Publications for TAS2R5 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4 64

Products for TAS2R5 Gene

Sources for TAS2R5 Gene

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