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Aliases for TAS2R5 Gene

Aliases for TAS2R5 Gene

  • Taste 2 Receptor Member 5 2 3 5
  • Taste Receptor, Type 2, Member 5 2 3
  • T2R5 3 4

External Ids for TAS2R5 Gene

Previous GeneCards Identifiers for TAS2R5 Gene

  • GC07P139760
  • GC07P140820
  • GC07P140897
  • GC07P140943
  • GC07P141136
  • GC07P141490
  • GC07P135786
  • GC07P142613
  • GC07P142906

Summaries for TAS2R5 Gene

Entrez Gene Summary for TAS2R5 Gene

  • This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R5 Gene

TAS2R5 (Taste 2 Receptor Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R5 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R5 Gene

Genomics for TAS2R5 Gene

Regulatory Elements for TAS2R5 Gene

Genomic Location for TAS2R5 Gene

Chromosome:
7
Start:
141,790,217 bp from pter
End:
141,791,367 bp from pter
Size:
1,151 bases
Orientation:
Plus strand

Genomic View for TAS2R5 Gene

Genes around TAS2R5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R5 Gene

Proteins for TAS2R5 Gene

  • Protein details for TAS2R5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW4-TA2R5_HUMAN
    Recommended name:
    Taste receptor type 2 member 5
    Protein Accession:
    Q9NYW4
    Secondary Accessions:
    • Q645W0
    • Q75MV7

    Protein attributes for TAS2R5 Gene

    Size:
    299 amino acids
    Molecular mass:
    34505 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R5 Gene

Proteomics data for TAS2R5 Gene at MOPED

Post-translational modifications for TAS2R5 Gene

  • Glycosylation at Asn 155
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R5 Gene

Domains & Families for TAS2R5 Gene

Gene Families for TAS2R5 Gene

Protein Domains for TAS2R5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW4

UniProtKB/Swiss-Prot:

TA2R5_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R5: view

Function for TAS2R5 Gene

Molecular function for TAS2R5 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
genes like me logo Genes that share phenotypes with TAS2R5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R5 Gene

Localization for TAS2R5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R5 Gene COMPARTMENTS Subcellular localization image for TAS2R5 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R5 Gene

Pathways & Interactions for TAS2R5 Gene

genes like me logo Genes that share pathways with TAS2R5: view

Pathways by source for TAS2R5 Gene

1 Qiagen pathway for TAS2R5 Gene

Interacting Proteins for TAS2R5 Gene

Gene Ontology (GO) - Biological Process for TAS2R5 Gene

None

No data available for SIGNOR curated interactions for TAS2R5 Gene

Drugs & Compounds for TAS2R5 Gene

(1) Drugs for TAS2R5 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,10-phenanthroline Experimental Pharma 0
genes like me logo Genes that share compounds with TAS2R5: view

Transcripts for TAS2R5 Gene

mRNA/cDNA for TAS2R5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R5 Gene

Taste receptor, type 2, member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R5 Gene

No ASD Table

Relevant External Links for TAS2R5 Gene

GeneLoc Exon Structure for
TAS2R5
ECgene alternative splicing isoforms for
TAS2R5

Expression for TAS2R5 Gene

mRNA expression in normal human tissues for TAS2R5 Gene

SOURCE GeneReport for Unigene cluster for TAS2R5 Gene Hs.675370

mRNA Expression by UniProt/SwissProt for TAS2R5 Gene

Q9NYW4-TA2R5_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R5 Gene

Orthologs for TAS2R5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R5 36
  • 97 (a)
OneToOne
TAS2R5 35
  • 98.55 (n)
  • 97.32 (a)
dog
(Canis familiaris)
Mammalia TAS2R5 36
  • 76 (a)
OneToOne
TAS2R5 35
  • 85.5 (n)
  • 76.37 (a)
mouse
(Mus musculus)
Mammalia Tas2r143 36
  • 25 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R2 36
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TAS2R7 36
  • 22 (a)
OneToMany
Species with no ortholog for TAS2R5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R5 Gene

ENSEMBL:
Gene Tree for TAS2R5 (if available)
TreeFam:
Gene Tree for TAS2R5 (if available)

Paralogs for TAS2R5 Gene

genes like me logo Genes that share paralogs with TAS2R5: view

Variants for TAS2R5 Gene

Sequence variations from dbSNP and Humsavar for TAS2R5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2227264 - 141,790,438(+) TGGAA(A/G/T)CCTGG reference, missense
rs2234015 - 141,790,999(+) TGTCC(A/G)GGCCA reference, missense
rs2234014 - 141,790,699(+) TCGCC(C/T)GGCCT reference, missense
rs34529840 - 141,790,861(+) GCAGT(A/G)CCTGT reference, missense
rs2234013 - 141,790,419(+) TCATC(A/G)GTTTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R5 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Variation tolerance for TAS2R5 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R5 Gene

HapMap Linkage Disequilibrium report
TAS2R5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R5 Gene

Disorders for TAS2R5 Gene

Relevant External Links for TAS2R5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R5

No disorders were found for TAS2R5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R5 Gene

Publications for TAS2R5 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 67
  2. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  3. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. The receptors and cells for mammalian taste. (PMID: 17108952) Chandrashekar J. … Zuker C.S. (Nature 2006) 3

Products for TAS2R5 Gene

Sources for TAS2R5 Gene

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