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Aliases for TAS2R46 Gene

Aliases for TAS2R46 Gene

  • Taste Receptor, Type 2, Member 46 2 3
  • T2R46 3 4 6
  • T2R54 3 4 6
  • Taste Receptor Type 2 Member 54 3 4
  • Taste Receptor Type 2 Member 46 3

External Ids for TAS2R46 Gene

Summaries for TAS2R46 Gene

Entrez Gene Summary for TAS2R46 Gene

  • TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]

GeneCards Summary for TAS2R46 Gene

TAS2R46 (Taste Receptor, Type 2, Member 46) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R46 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Gene Wiki entry for TAS2R46 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R46 Gene

Genomics for TAS2R46 Gene

Genomic Location for TAS2R46 Gene

Start:
11,061,365 bp from pter
End:
11,062,294 bp from pter
Size:
930 bases
Orientation:
Minus strand

Genomic View for TAS2R46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R46 Gene

Regulatory Elements for TAS2R46 Gene

Proteins for TAS2R46 Gene

  • Protein details for TAS2R46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59540-T2R46_HUMAN
    Recommended name:
    Taste receptor type 2 member 46
    Protein Accession:
    P59540
    Secondary Accessions:
    • P59548
    • Q645X6

    Protein attributes for TAS2R46 Gene

    Size:
    309 amino acids
    Molecular mass:
    35523 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R46 Gene

Proteomics data for TAS2R46 Gene at MOPED

Post-translational modifications for TAS2R46 Gene

  • Glycosylation at Asn161 and Asn176

Other Protein References for TAS2R46 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R46 Gene

Domains for TAS2R46 Gene

Gene Families for TAS2R46 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R46 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T2R46_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • P59540
genes like me logo Genes that share domains with TAS2R46: view

Function for TAS2R46 Gene

Molecular function for TAS2R46 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R46: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R46 Gene

Localization for TAS2R46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R46 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Gene Ontology (GO) - Cellular Components for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium --
GO:0016021 integral component of membrane IC 20022913
GO:0060170 ciliary membrane IEA --
genes like me logo Genes that share ontologies with TAS2R46: view

Pathways for TAS2R46 Gene

genes like me logo Genes that share pathways with TAS2R46: view

Pathways by source for TAS2R46 Gene

Interacting Proteins for TAS2R46 Gene

Gene Ontology (GO) - Biological Process for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R46: view

Compounds for TAS2R46 Gene

(27) BitterDB Compounds for TAS2R46 Gene

Compound Smiles Cas Number
Absinthin C[C]1[C@]2CC[C@](C)(O)[C@]3[C]4[C@]5C=C(C)[C@@]6([C]7OC(=O)[C@](C)[C@]7CC[C@](C)(O)[C]56)[C]4C(=C3[C]2OC1=O)C 1362-42-1
amarogentin OC[C]1O[C@](O[C@]2OC=C3[C@](CCOC3=O)[C]2C=C)[C](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@](O)[C@]1O 21018-84-8
andrographolide C[C@@]1(CO)[C](O)CC[C@@]2(C)[C](CC=C3/[C](O)COC3=O)C(=C)CC[C]12 5508-58-7
Arborescin CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O
Arglabin CC1=CC[C@]23O[C@@]2(C)CC[C@]4[C](OC(=O)C4=C)[C]13
Artemorin CC1=C/[C]2OC(=O)C(=C)[C@]2CCC(=C)[C](O)CC1
Azathioprine Cn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]
brucine COc1cc2N3C4[C@]5C(CC3=O)OCC=C6CN7CC[C@]4([C@]7C[C]56)c2cc1OC 357-57-3
Caffeine CN1C(=O)N(C)c2ncn(C)c2C1=O 58-08-2
Cascarillin C[C@]1[C@](C[C@]2(C)[C](CC[C@](O)[C@]2(C)O)[C@]1(C[C@](O)c3cocc3)C=O)OC(=O)C 10118-56-6
chloramphenicol OC[C@](NC(=O)C(Cl)Cl)[C](O)c1ccc(cc1)[N+](=O)[O-]
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
cnicin CC1=C/CCC(=C[C]2OC(=O)C(=C)[C@]2[C](C1)OC(=O)C(=C)[C@](O)CO)CO
colchicine COC1=CC=C2C(=CC1=O)[C](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C
crispolide C[C@]12CC[C@](OO)C(=CC[C@]3[C](OC(=O)C3=C)[C]1O)C2
denatonium benzoate CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 3734-33-6
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
Grosheimin,grossheimin CC1C2C3OC(=O)C(=C)C3C(O)CC(=C)C2CC1=O
Hydrocortisone C[C@]12CCC(=O)C=C1CC[C]3[C@]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C](O)[C]23 50-23-7
orphenadrine CN(C)CCOC(c1ccccc1)c2ccccc2C
Parthenolide CC1=C/CC[C@@]2(C)O[C]2[C]3OC(=O)C(=C)[C@]3CC1
Picrotoxinin CC(=C)[C@]1[C]2OC(=O)[C@]1[C@]3(O)C[C]4O[C@]45C(=O)O[C]2[C@]35C 17617-45-7
Quassin COC1=C[C@](C)[C@]2C[C]3OC(=O)C[C]4C(=C(OC)C(=O)[C@]([C@@]34C)[C@@]2(C)C1=O)C 76-78-8
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
strychnine O=C1C[C@]2OCC=C3CN4CC[C@@]56[C@]4C[C@]3[C@]2[C@]5N1c7ccccc67 57-24-9
tatridin B CC1=C/[C@](O)[C]2[C](CC(=C)[C@](O)CC1)OC(=O)C2=C
yohimbine COC(=O)[C]1[C@](O)CC[C]2CN3CCc4c([nH]c5ccccc45)[C@]3C[C]12
genes like me logo Genes that share compounds with TAS2R46: view

Transcripts for TAS2R46 Gene

mRNA/cDNA for TAS2R46 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R46 Gene

No ASD Table

Relevant External Links for TAS2R46 Gene

GeneLoc Exon Structure for
TAS2R46
ECgene alternative splicing isoforms for
TAS2R46

Expression for TAS2R46 Gene

mRNA expression in normal human tissues for TAS2R46 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TAS2R46 Gene

SOURCE GeneReport for Unigene cluster for TAS2R46 Gene Hs.688193

mRNA Expression by UniProt/SwissProt for TAS2R46 Gene

P59540-T2R46_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.
genes like me logo Genes that share expressions with TAS2R46: view

Orthologs for TAS2R46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R46 36
  • 98.92 (n)
  • 97.73 (a)
TAS2R46 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 58 (a)
ManyToMany
TAS2R46 36
  • 75.03 (n)
  • 59.41 (a)
TAS2R46 37
  • 57 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 36
  • 75.9 (n)
  • 62.54 (a)
CAFA-T2R43 37
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 36
  • 67.25 (n)
  • 51.39 (a)
Tas2r120 37
  • 50 (a)
ManyToMany
Tas2r136 37
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 37
  • 32 (a)
ManyToMany
T2R24 37
  • 35 (a)
ManyToMany
T2R25 37
  • 35 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tas2r120 36
  • 65.48 (n)
  • 50.18 (a)
Species with no ortholog for TAS2R46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R46 Gene

ENSEMBL:
Gene Tree for TAS2R46 (if available)
TreeFam:
Gene Tree for TAS2R46 (if available)

Paralogs for TAS2R46 Gene

genes like me logo Genes that share paralogs with TAS2R46: view

Variants for TAS2R46 Gene

Sequence variations from dbSNP and Humsavar for TAS2R46 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_062091 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R46 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
esv2745546 CNV Deletion 23290073
esv8289 CNV Loss 19470904
nsv898780 CNV Loss 21882294
esv2670207 CNV Deletion 23128226
dgv265e199 CNV Deletion 23128226
dgv35e19 CNV Loss 19470904
nsv8917 CNV Loss 18304495
dgv191e201 CNV Deletion 23290073
dgv267e199 CNV Deletion 23128226
nsv436149 CNV Deletion 17901297
nsv898781 CNV Loss 21882294
nsv898782 CNV Loss 21882294
dgv1374n71 CNV Loss 21882294
esv2665068 CNV Deletion 23128226
esv7358 CNV Loss 19470904
esv2675860 CNV Deletion 23128226
esv2745548 CNV Deletion 23290073
esv2745549 CNV Deletion 23290073
dgv36e19 CNV Loss 19470904

Relevant External Links for TAS2R46 Gene

HapMap Linkage Disequilibrium report
TAS2R46

Disorders for TAS2R46 Gene

No disorders were found for TAS2R46 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R46 Gene

Publications for TAS2R46 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4
  2. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  3. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PMID: 12584440) Conte C. … Andres-Barquin P.J. (Cytogenet. Genome Res. 2002) 3 4

Products for TAS2R46 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TAS2R46
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R46
    • Block miRNA regulation of TAS2R46 using miScript Target Protectors

    Sources for TAS2R46 Gene

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