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Aliases for TAS2R46 Gene

Aliases for TAS2R46 Gene

  • Taste 2 Receptor Member 46 2 3 5
  • Taste Receptor, Type 2, Member 46 2 3
  • Taste Receptor Type 2 Member 54 3 4
  • T2R46 3 4
  • T2R54 3 4
  • Taste Receptor Type 2 Member 46 3

External Ids for TAS2R46 Gene

Previous GeneCards Identifiers for TAS2R46 Gene

  • GC00U991255
  • GC12M011114
  • GC12M011107
  • GC12M011108
  • GC12M011109
  • GC12M011214
  • GC12M011063
  • GC12M011247
  • GC12M011342
  • GC12M011557

Summaries for TAS2R46 Gene

Entrez Gene Summary for TAS2R46 Gene

  • TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]

GeneCards Summary for TAS2R46 Gene

TAS2R46 (Taste 2 Receptor Member 46) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R43.

UniProtKB/Swiss-Prot for TAS2R46 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Gene Wiki entry for TAS2R46 Gene

Additional gene information for TAS2R46 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R46 Gene

Genomics for TAS2R46 Gene

Regulatory Elements for TAS2R46 Gene

Enhancers for TAS2R46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H010152 1.1 Ensembl ENCODE 10.5 +908.6 908583 1.8 ZNF2 RAD21 YY1 GLIS2 ZNF143 RUNX3 DEK ZNF202 ZNF654 ZNF680 KLRA1P LOC642846 TAS2R20 GABARAPL1 ENSG00000255958 TAS2R50 ENSG00000256682 DDX12P TAS2R43 TAS2R46
GH12H011070 0.8 ENCODE 0.4 -9.0 -8959 1.4 SOX13 FOXA2 CEBPG RAD21 RARA RERE NR2F6 HOMEZ SOX5 GATAD2A ENSG00000256274 TAS2R15P TAS2R46 TAS2R64P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R46 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TAS2R46 Gene

Genomic Locations for TAS2R46 Gene
chr12:11,061,365-11,062,294
(GRCh38/hg38)
Size:
930 bases
Orientation:
Minus strand
chr12:11,213,964-11,214,893
(GRCh37/hg19)

Genomic View for TAS2R46 Gene

Genes around TAS2R46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R46 Gene

Proteins for TAS2R46 Gene

  • Protein details for TAS2R46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59540-T2R46_HUMAN
    Recommended name:
    Taste receptor type 2 member 46
    Protein Accession:
    P59540
    Secondary Accessions:
    • P59548
    • Q645X6

    Protein attributes for TAS2R46 Gene

    Size:
    309 amino acids
    Molecular mass:
    35523 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R46 Gene

Post-translational modifications for TAS2R46 Gene

  • Glycosylation at posLast=161161 and Asn176
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R46 Gene

Domains & Families for TAS2R46 Gene

Gene Families for TAS2R46 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R46 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59540

UniProtKB/Swiss-Prot:

T2R46_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R46: view

Function for TAS2R46 Gene

Molecular function for TAS2R46 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R46: view

Phenotypes for TAS2R46 Gene

genes like me logo Genes that share phenotypes with TAS2R46: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R46 Gene

Localization for TAS2R46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R46 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R46 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TAS2R46: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R46 Gene

Pathways & Interactions for TAS2R46 Gene

genes like me logo Genes that share pathways with TAS2R46: view

Pathways by source for TAS2R46 Gene

Interacting Proteins for TAS2R46 Gene

Gene Ontology (GO) - Biological Process for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R46: view

No data available for SIGNOR curated interactions for TAS2R46 Gene

Drugs & Compounds for TAS2R46 Gene

(15) Drugs for TAS2R46 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 183
Chloramphenicol Approved, Vet_approved Pharma 7
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 116
Diphenidol Approved, Withdrawn Pharma 1
Hydrocortisone Approved, Vet_approved Pharma Agonist 685

(12) Additional Compounds for TAS2R46 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
amarogentin
21018-84-8
Arborescin
Arglabin
Artemorin
genes like me logo Genes that share compounds with TAS2R46: view

Transcripts for TAS2R46 Gene

mRNA/cDNA for TAS2R46 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R46 Gene

No ASD Table

Relevant External Links for TAS2R46 Gene

GeneLoc Exon Structure for
TAS2R46
ECgene alternative splicing isoforms for
TAS2R46

Expression for TAS2R46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R46 Gene

Protein differential expression in normal tissues from HIPED for TAS2R46 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R46 Gene



Protein tissue co-expression partners for TAS2R46 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R46 Gene:

TAS2R46

SOURCE GeneReport for Unigene cluster for TAS2R46 Gene:

Hs.688193

mRNA Expression by UniProt/SwissProt for TAS2R46 Gene:

P59540-T2R46_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.
genes like me logo Genes that share expression patterns with TAS2R46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R46 Gene

Orthologs for TAS2R46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R46 33 34
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia CAFA-T2R43 33 34
  • 75.9 (n)
cow
(Bos Taurus)
Mammalia TAS2R46 33 34
  • 75.03 (n)
-- 34
  • 58 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r120 33 16 34
  • 67.25 (n)
Tas2r136 34
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tas2r120 33
  • 65.48 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R24 34
  • 35 (a)
ManyToMany
T2R25 34
  • 35 (a)
ManyToMany
T2R23 34
  • 32 (a)
ManyToMany
Species where no ortholog for TAS2R46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R46 Gene

ENSEMBL:
Gene Tree for TAS2R46 (if available)
TreeFam:
Gene Tree for TAS2R46 (if available)

Paralogs for TAS2R46 Gene

genes like me logo Genes that share paralogs with TAS2R46: view

Variants for TAS2R46 Gene

Sequence variations from dbSNP and Humsavar for TAS2R46 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2708380 --

Structural Variations from Database of Genomic Variants (DGV) for TAS2R46 Gene

Variant ID Type Subtype PubMed ID
nsv1050050 CNV loss 25217958
nsv1054664 CNV gain 25217958
nsv1070510 CNV deletion 25765185
nsv1152044 CNV deletion 26484159
nsv428272 CNV gain+loss 18775914
nsv436149 CNV deletion 17901297
nsv8917 CNV loss 18304495
nsv951327 CNV duplication 24416366
nsv957429 CNV deletion 24416366
nsv983283 CNV duplication 23825009
nsv1038709 CNV loss 25217958
nsv1038323 CNV loss 25217958
nsv1038277 CNV loss 25217958
esv8289 CNV loss 19470904
esv7358 CNV loss 19470904
esv3548757 CNV deletion 23714750
esv3254051 CNV deletion 24192839
esv2760999 CNV gain+loss 21179565
esv2759879 CNV loss 17122850
esv2745549 CNV deletion 23290073
esv2745548 CNV deletion 23290073
esv2745546 CNV deletion 23290073
esv2675860 CNV deletion 23128226
esv2670207 CNV deletion 23128226
esv2665068 CNV deletion 23128226
dgv770n106 CNV deletion 24896259
dgv769n106 CNV deletion 24896259
dgv453e212 CNV gain 25503493
dgv43e19 CNV loss 19470904
dgv42e19 CNV loss 19470904
dgv267e199 CNV deletion 23128226
dgv265e199 CNV deletion 23128226
dgv172e201 CNV deletion 23290073
dgv1376n100 CNV gain+loss 25217958
dgv1375n100 CNV loss 25217958

Variation tolerance for TAS2R46 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R46 Gene

Human Gene Mutation Database (HGMD)
TAS2R46
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R46 Gene

Disorders for TAS2R46 Gene

Relevant External Links for TAS2R46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R46

No disorders were found for TAS2R46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R46 Gene

Publications for TAS2R46 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. (PMID: 12379855) Bufe B … Meyerhof W (Nature genetics 2002) 2 3 4 60
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 60
  3. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 60
  4. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee RF (The Journal of biological chemistry 2002) 3 4 60
  5. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur JP … Matsunami H (Current opinion in neurobiology 2002) 3 4 60

Products for TAS2R46 Gene

Sources for TAS2R46 Gene

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