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Aliases for TAS2R46 Gene

Aliases for TAS2R46 Gene

  • Taste Receptor, Type 2, Member 46 2 3
  • Taste Receptor Type 2 Member 54 3 4
  • T2R46 3 4
  • T2R54 3 4

External Ids for TAS2R46 Gene

Previous GeneCards Identifiers for TAS2R46 Gene

  • GC00U991255
  • GC12M011114
  • GC12M011107
  • GC12M011108
  • GC12M011109
  • GC12M011214

Summaries for TAS2R46 Gene

Entrez Gene Summary for TAS2R46 Gene

  • TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]

GeneCards Summary for TAS2R46 Gene

TAS2R46 (Taste Receptor, Type 2, Member 46) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R46 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Gene Wiki entry for TAS2R46 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R46 Gene

Genomics for TAS2R46 Gene

Regulatory Elements for TAS2R46 Gene

Genomic Location for TAS2R46 Gene

Chromosome:
12
Start:
11,061,365 bp from pter
End:
11,062,294 bp from pter
Size:
930 bases
Orientation:
Minus strand

Genomic View for TAS2R46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R46 Gene

Proteins for TAS2R46 Gene

  • Protein details for TAS2R46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59540-T2R46_HUMAN
    Recommended name:
    Taste receptor type 2 member 46
    Protein Accession:
    P59540
    Secondary Accessions:
    • P59548
    • Q645X6

    Protein attributes for TAS2R46 Gene

    Size:
    309 amino acids
    Molecular mass:
    35523 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R46 Gene

Proteomics data for TAS2R46 Gene at MOPED

Post-translational modifications for TAS2R46 Gene

  • Glycosylation at Asn 161 and Asn 176
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R46 Gene

Domains & Families for TAS2R46 Gene

Gene Families for TAS2R46 Gene

Protein Domains for TAS2R46 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59540

UniProtKB/Swiss-Prot:

T2R46_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R46: view

Function for TAS2R46 Gene

Molecular function for TAS2R46 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R46: view

Phenotypes for TAS2R46 Gene

GenomeRNAi human phenotypes for TAS2R46:
genes like me logo Genes that share phenotypes with TAS2R46: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R46

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R46 Gene

Localization for TAS2R46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R46 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R46 Gene COMPARTMENTS Subcellular localization image for TAS2R46 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
GO:0060170 ciliary membrane IEA --
genes like me logo Genes that share ontologies with TAS2R46: view

Pathways & Interactions for TAS2R46 Gene

genes like me logo Genes that share pathways with TAS2R46: view

Pathways by source for TAS2R46 Gene

Interacting Proteins for TAS2R46 Gene

Gene Ontology (GO) - Biological Process for TAS2R46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R46: view

No data available for SIGNOR curated interactions for TAS2R46 Gene

Drugs & Compounds for TAS2R46 Gene

(15) Drugs for TAS2R46 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 145
Chloramphenicol Approved Pharma 6
Chlorpheniramine Approved Pharma 54
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 103
Diphenidol Approved, Withdrawn Pharma 1

(12) Additional Compounds for TAS2R46 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
amarogentin
21018-84-8
Arborescin
Arglabin
Artemorin
genes like me logo Genes that share compounds with TAS2R46: view

Transcripts for TAS2R46 Gene

mRNA/cDNA for TAS2R46 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R46

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R46 Gene

No ASD Table

Relevant External Links for TAS2R46 Gene

GeneLoc Exon Structure for
TAS2R46
ECgene alternative splicing isoforms for
TAS2R46

Expression for TAS2R46 Gene

mRNA expression in normal human tissues for TAS2R46 Gene

Protein differential expression in normal tissues from HIPED for TAS2R46 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAS2R46 Gene



SOURCE GeneReport for Unigene cluster for TAS2R46 Gene Hs.688193

mRNA Expression by UniProt/SwissProt for TAS2R46 Gene

P59540-T2R46_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.
genes like me logo Genes that share expression patterns with TAS2R46: view

Protein tissue co-expression partners for TAS2R46 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAS2R46 Gene

Orthologs for TAS2R46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAS2R46 35
  • 75.03 (n)
  • 59.41 (a)
-- 36
  • 58 (a)
ManyToMany
TAS2R46 36
  • 57 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 35
  • 75.9 (n)
  • 62.54 (a)
CAFA-T2R43 36
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 35
  • 67.25 (n)
  • 51.39 (a)
Tas2r120 36
  • 50 (a)
ManyToMany
Tas2r136 36
  • 42 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia TAS2R46 35
  • 98.92 (n)
  • 97.73 (a)
TAS2R46 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r120 35
  • 65.48 (n)
  • 50.18 (a)
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 32 (a)
ManyToMany
T2R24 36
  • 35 (a)
ManyToMany
T2R25 36
  • 35 (a)
ManyToMany
Species with no ortholog for TAS2R46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R46 Gene

ENSEMBL:
Gene Tree for TAS2R46 (if available)
TreeFam:
Gene Tree for TAS2R46 (if available)

Paralogs for TAS2R46 Gene

genes like me logo Genes that share paralogs with TAS2R46: view

Variants for TAS2R46 Gene

Sequence variations from dbSNP and Humsavar for TAS2R46 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_062091 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R46 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
esv2745546 CNV Deletion 23290073
esv8289 CNV Loss 19470904
nsv898780 CNV Loss 21882294
esv2670207 CNV Deletion 23128226
dgv265e199 CNV Deletion 23128226
dgv35e19 CNV Loss 19470904
nsv8917 CNV Loss 18304495
dgv191e201 CNV Deletion 23290073
dgv267e199 CNV Deletion 23128226
nsv436149 CNV Deletion 17901297
nsv898781 CNV Loss 21882294
nsv898782 CNV Loss 21882294
dgv1374n71 CNV Loss 21882294
esv2665068 CNV Deletion 23128226
esv7358 CNV Loss 19470904
esv2675860 CNV Deletion 23128226
esv2745548 CNV Deletion 23290073
esv2745549 CNV Deletion 23290073
dgv36e19 CNV Loss 19470904

Variation tolerance for TAS2R46 Gene

Residual Variation Intolerance Score: 94.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R46 Gene

HapMap Linkage Disequilibrium report
TAS2R46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R46 Gene

Disorders for TAS2R46 Gene

Relevant External Links for TAS2R46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R46
genes like me logo Genes that share disorders with TAS2R46: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R46 Gene

Publications for TAS2R46 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 67
  2. GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. (PMID: 23966204) Ledda M. … Genick U.K. (Hum. Mol. Genet. 2014) 67
  3. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. (PMID: 23520545) Lund T.C. … Tolar J. (PLoS ONE 2013) 67
  4. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 67
  5. Motile cilia of human airway epithelia are chemosensory. (PMID: 19628819) Shah A.S. … Welsh M.J. (Science 2009) 67

Products for TAS2R46 Gene

Sources for TAS2R46 Gene

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