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Aliases for TAS2R45 Gene

Aliases for TAS2R45 Gene

  • Taste 2 Receptor Member 45 2 3
  • Taste Receptor, Type 2, Member 45 2 3
  • G-Protein Coupled Receptor 59 3 4
  • GPR59 3 4
  • T2R45 3 4
  • G Protein-Coupled Receptor 59 2
  • ZG24P 3

External Ids for TAS2R45 Gene

Previous HGNC Symbols for TAS2R45 Gene

  • GPR59

Previous GeneCards Identifiers for TAS2R45 Gene

  • GC00U991254
  • GC12M011106
  • GC00P9A0411
  • GC12P9J0411
  • GC12U900566
  • GC12M011213
  • GC12M011012
  • GC12M9R0327

Summaries for TAS2R45 Gene

GeneCards Summary for TAS2R45 Gene

TAS2R45 (Taste 2 Receptor Member 45) is a Protein Coding gene. Among its related pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include bitter taste receptor activity.

UniProtKB/Swiss-Prot for TAS2R45 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R45 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R45 Gene

Genomics for TAS2R45 Gene

Regulatory Elements for TAS2R45 Gene

Enhancers for TAS2R45 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R45 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R45 Gene

Chromosome:
12
Start:
327,525 bp from pter
End:
328,424 bp from pter
Size:
900 bases
Orientation:
Minus strand

Genomic View for TAS2R45 Gene

Genes around TAS2R45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
  • 12 alternate reference locus by HGNC
GeneLoc Logo Gene Density

No data available for RefSeq DNA sequence for TAS2R45 Gene

Proteins for TAS2R45 Gene

  • Protein details for TAS2R45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59539-T2R45_HUMAN
    Recommended name:
    Taste receptor type 2 member 45
    Protein Accession:
    P59539

    Protein attributes for TAS2R45 Gene

    Size:
    299 amino acids
    Molecular mass:
    34278 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R45 Gene

Proteomics data for TAS2R45 Gene at MOPED

Post-translational modifications for TAS2R45 Gene

  • Glycosylation at Asn 161
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R45 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R45 Gene

Domains & Families for TAS2R45 Gene

Gene Families for TAS2R45 Gene

Protein Domains for TAS2R45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R45 Gene

Graphical View of Domain Structure for InterPro Entry

P59539

UniProtKB/Swiss-Prot:

T2R45_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R45: view

Function for TAS2R45 Gene

Molecular function for TAS2R45 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033038 NOT bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R45: view
genes like me logo Genes that share phenotypes with TAS2R45: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R45 Gene

Localization for TAS2R45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R45 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TAS2R45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 20022913
genes like me logo Genes that share ontologies with TAS2R45: view

No data available for Subcellular locations from COMPARTMENTS for TAS2R45 Gene

Pathways & Interactions for TAS2R45 Gene

genes like me logo Genes that share pathways with TAS2R45: view

Pathways by source for TAS2R45 Gene

Interacting Proteins for TAS2R45 Gene

Gene Ontology (GO) - Biological Process for TAS2R45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 NOT detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TAS2R45: view

No data available for SIGNOR curated interactions for TAS2R45 Gene

Drugs & Compounds for TAS2R45 Gene

No Compound Related Data Available

Transcripts for TAS2R45 Gene

mRNA/cDNA for TAS2R45 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:

Unigene Clusters for TAS2R45 Gene

Taste receptor, type 2, member 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R45 Gene

No ASD Table

Relevant External Links for TAS2R45 Gene

GeneLoc Exon Structure for
TAS2R45
ECgene alternative splicing isoforms for
TAS2R45

Expression for TAS2R45 Gene

mRNA expression in normal human tissues for TAS2R45 Gene

SOURCE GeneReport for Unigene cluster for TAS2R45 Gene Hs.287378

mRNA Expression by UniProt/SwissProt for TAS2R45 Gene

P59539-T2R45_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R45 Gene

Orthologs for TAS2R45 Gene

No data available for Orthologs and Evolution for TAS2R45 Gene

Paralogs for TAS2R45 Gene

genes like me logo Genes that share paralogs with TAS2R45: view

No data available for Paralogs for TAS2R45 Gene

Variants for TAS2R45 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for TAS2R45 Gene

Disorders for TAS2R45 Gene

No disorders were found for TAS2R45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TAS2R45 Gene

Publications for TAS2R45 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4 67
  2. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  3. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PMID: 15744053) Go Y. … Takahata N. (Genetics 2005) 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3

Products for TAS2R45 Gene

Sources for TAS2R45 Gene

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