TAS2R45 Gene
protein-coding GIFtS: 37
GCID: GC12U900566
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taste receptor, type 2, member 45(Previous name: G protein-coupled receptor 59 )
(Previous symbol: GPR59)
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Aliases
for TAS2R45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 2, Member 451 2 | | T2R452 3 | | GPR591 2 3 | | G-Protein Coupled Receptor 592 3 | | ZG24P1 2 | | Taste Receptor Type 2 Member 452 | | G Protein-Coupled Receptor 591 2 | | |
Export aliases for TAS2R45 gene to outside databasesPrevious GC identifers: GC00U991254 GC12M011106 GC00P9A0411 GC12P9J0411 GC12M011213 GC12M011012 |
Summaries
for TAS2R45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)
Gene Wiki entry for TAS2R45
|
Genomic Views
for TAS2R45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:NC_018923.1 Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TAS2R45
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R45
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R45 |
Genomic Location:
Chromosome:12
HGNC chromosome: 12GeneLoc information about chromosome 12 |
Proteins
for TAS2R45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539 (See
protein sequence)Recommended Name: Taste receptor type 2 member 45 Size: 299 amino acids; 34278 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells candiscriminate among bitter stimuliExplore the universe of human proteins at neXtProt for TAS2R45: NX_P59539
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59539
TAS2R45 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_795367.2
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
TAS2R45 for ontologies About GeneDecksing
TAS2R45 Antibody Products:
Assay Products for TAS2R45: |
Protein
Domains /
Families
for TAS2R45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R45 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P59539ProtoNet protein and cluster: P59539 UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539Similarity: Belongs to the G-protein coupled receptor T2R family |
Function
for TAS2R45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R45
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R45
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAS2R45 (NM_176886) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R45 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R45 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
TAS2R45 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TAS2R45:
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Pathways & Interactions
for TAS2R45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Taste transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for TAS2R45):
TAS2R45 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R45
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050909 | sensory perception of taste |
IEA | -- |
TAS2R45 for ontologies About GeneDecksing
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Drugs & Compounds
for TAS2R45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS2R45
Search CenterWatch for drugs/clinical trials and news about TAS2R45 / T2R45
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Transcripts
for TAS2R45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS2R45 gene: NM_176886.2 Unigene Cluster for TAS2R45: Taste receptor, type 2, member 45 Hs.287378 [show with all ESTs]Unigene Representative Sequence: NM_176886
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R45
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R45
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS2R45 (NM_176886) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R45 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R45 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TAS2R45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R45 |
Additional cDNA sequence: AF264628.1 BC101154.1 BC101156.1 2 DOTS entries: DT.121204118 DT.86859104 3 AceView cDNA sequences: NM_176886 AW266498 AF264628
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Expression
for TAS2R45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS2R45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGCCAAG
About this image
Genevestigator expression for TAS2R45
SOURCE GeneReport for Unigene cluster: Hs.287378
UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positivecells
SABiosciences Custom PCR Arrays for TAS2R45
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TAS2R45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R45 |
Orthologs
for TAS2R45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for TAS2R45 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TAS2R45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): TAS2R45
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TAS2R45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TAS2R45 for disorders About MalaCards
TAS2R45 for disorders About GeneDecksing
OMIM gene information: 613967
OMIM disorders: --
Export disorders for TAS2R45 gene to outside databases
|
Publications
for TAS2R45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS2R45 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAS2R45) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TAS2R45 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TAS2R45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS2R45 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TAS2R45 gene:
Search GeneIP for patents involving TAS2R45
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAS2R45 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAS2R45 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R45 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAS2R45 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R45 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R45 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | |  |  |  | | | | ThermoFisher Antibodies for TAS2R45 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R45 |
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