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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R45 Gene

protein-coding   GIFtS: 40
GCID: GC12M9R0327

Taste Receptor, Type 2, Member 45

(Previous name: G protein-coupled receptor 59)
(Previous symbol: GPR59)
  Search for TAS2R45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 451 2     G-Protein Coupled Receptor 592 3
GPR591 2 3     ZG24P2
G Protein-Coupled Receptor 591 2     Taste Receptor Type 2 Member 452
T2R452 3     

External Ids:    HGNC: 188761   Entrez Gene: 2592912   OMIM: 6139675   UniProtKB: P595393   

Export aliases for TAS2R45 gene to outside databases

Previous GC identifers: GC00U991254 GC12M011106 GC00P9A0411 GC12P9J0411 GC12U900566 GC12M011213 GC12M011012


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TAS2R45 Gene: 
TAS2R45 (taste receptor, type 2, member 45) is a protein-coding gene. Among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R45 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TAS2R45
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TAS2R45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R45


Genomic Location:
Chromosome:12   

HGNC chromosome: 12

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M9R0327:       (about GC identifiers)

Start:
327,525 bp from start of contig NW_003571050      End:
328,424 bp from start of contig NW_003571050
Size:
900 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539 (See protein sequence)
Recommended Name: Taste receptor type 2 member 45  
Size: 299 amino acids; 34278 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli

Explore the universe of human proteins at neXtProt for TAS2R45: NX_P59539

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59539

  • TAS2R45 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_795367.2  Reactome Protein details: P59539
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    TAS2R45 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59539

    ProtoNet protein and cluster: P59539

    UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539
    Similarity: Belongs to the G-protein coupled receptor T2R family


    TAS2R45 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R45_HUMAN, P59539
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    TAS2R45 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAS2R45:
     Decreased POU5F1-GFP protein e  Decreased viability with pacli 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAS2R45 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class C/3 (Metabotropic glutamate/pheromone receptors)
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for TAS2R45 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for TAS2R45):
        Taste transduction


    TAS2R45 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R45

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050909sensory perception of taste IEA--

    TAS2R45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAS2R45 (T2R45)

    Search CenterWatch for drugs/clinical trials and news about TAS2R45 / T2R45

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAS2R45 gene: 
    NM_176886.2  

    Unigene Cluster for TAS2R45:

    Taste receptor, type 2, member 45
    Hs.287378  [show with all ESTs]
    Unigene Representative Sequence: NM_176886
    miRNA
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    Additional mRNA sequence: 

    AF264628.1 BC101154.1 BC101156.1 

    2 DOTS entries:

    DT.121204118  DT.86859104 

    3 AceView cDNA sequences:

    NM_176886 AW266498 AF264628 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAS2R45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGCCAAG
    TAS2R45 Expression
    About this image


    Genevestigator expression for TAS2R45

    SOURCE GeneReport for Unigene cluster: Hs.287378

    UniProtKB/Swiss-Prot: T2R45_HUMAN, P59539
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAS2R45 gene
    18/53 SIMAP similar genes for TAS2R45 using alignment to 2 protein entries:     T2R45_HUMAN (see all proteins) (see all similar genes):
    Hosa(Japanese)-T2R45    TAS2R46    Hosa(Adygei)-T2R46    Hosa(Biaka)-T2R46    Hosa(Biaka)-T2R43    TAS2R43
    TAS2R31    Hosa(Biaka)-T2R47    TAS2R30    Hosa(Biaka)-T2R48    Hosa(Japanese)-T2R48    Hosa(Adygei)-T2R50
    TAS2R50    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R50    TAS2R19    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R49

    TAS2R45 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 SNPs in TAS2R45 are shown (see all 90)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740624341,2
    C,F--11118538(+) TTTCCG/AGGGAT 1 -- ds50013Minor allele frequency- A:0.13WA CSA 121
    rs780724571,2
    C--11118553(+) TCTTAC/GTTCTT 1 -- ds50010--------
    rs730649591,2
    C--11118580(+) CATTGC/TAAATT 1 -- ds50010--------
    rs1897133981,2
    --11118613(+) ATGAAC/TGAAAT 1 -- ds50010--------
    rs3758436191,2
    C--11118620(+) AAATAA/TCATGG 1 -- ds50010--------
    rs1394219621,2
    --11118736(+) ACACAA/CATACA 1 -- ds50010--------
    rs1869947631,2
    --11118762(+) ATTTTC/TTAGAC 1 -- ds50010--------
    rs789659281,2
    C,F--11118793(+) GTATAC/TGTTTG 1 -- ds50012Minor allele frequency- T:0.47WA NA 238
    rs1834018791,2
    --11118814(+) ATACAC/GATACA 1 -- ds50010--------
    rs1451799171,2
    --11118820(+) ATACAG/TTATAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TAS2R45 (327525 - 328424 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAS2R45: --

    Human Gene Mutation Database (HGMD): TAS2R45
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R45
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TAS2R45 for disorders           About MalaCards
    OMIM gene information: 613967    OMIM disorders: --


    TAS2R45 for disorders           About GeneDecksing


    Export disorders for TAS2R45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAS2R45 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TAS2R45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
    2. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
    3. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
    4. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
    5. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 259291 HGNC: 18876 AceView: TAS2R45 euGenes: HUgn259291 ECgene: TAS2R45 Kegg: 259291
    H-InvDB: TAS2R45

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAS2R45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAS2R45 gene:
    Search GeneIP for patents involving TAS2R45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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