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Aliases for TAS2R43 Gene

Aliases for TAS2R43 Gene

  • Taste 2 Receptor Member 43 2 3 5
  • Taste Receptor, Type 2, Member 43 2 3
  • Taste Receptor Type 2 Member 52 3 4
  • T2R43 3 4
  • T2R52 3 4
  • Taste Receptor Type 2 Member 43 3

External Ids for TAS2R43 Gene

Previous GeneCards Identifiers for TAS2R43 Gene

  • GC00U991252
  • GC12M011144
  • GC12M011135
  • GC12M9J0020
  • GC12M011215
  • GC12M011243

Summaries for TAS2R43 Gene

Entrez Gene Summary for TAS2R43 Gene

  • TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

GeneCards Summary for TAS2R43 Gene

TAS2R43 (Taste 2 Receptor Member 43) is a Protein Coding gene. Diseases associated with TAS2R43 include Balkan Nephropathy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R31.

UniProtKB/Swiss-Prot for TAS2R43 Gene

  • Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).

Gene Wiki entry for TAS2R43 Gene

Additional gene information for TAS2R43 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R43 Gene

Genomics for TAS2R43 Gene

Regulatory Elements for TAS2R43 Gene

Enhancers for TAS2R43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H010715 1.4 ENCODE dbSUPER 36.8 +372.2 372219 8 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS KLRA1P TAS2R20 TAS2R43 TAS2R31 MAGOHB ENSG00000256682 LINC02366 SLC25A39P2 HNRNPABP1 LOC100419929
GH12H011743 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -659.8 -659756 18 HDGF PKNOX1 ATF1 TBL1XR1 BMI1 BATF RAD21 YY1 ZNF207 ATF7 ETV6 BCL2L14 TAS2R43 TAS2R20 TAS2R50 ENSG00000256682 ENSG00000256981 TAS2R14 DDX55P1 LINC01252
GH12H010611 1.2 ENCODE 22 +479.0 478968 2 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KLRA1P TAS2R43 ENSG00000256682 SLC25A39P2 LINC02366 ENSG00000213443 HNRNPABP1 LOC100419929 LOC255308 ENSG00000257027
GH12H010384 1.4 FANTOM5 ENCODE dbSUPER 18.8 +704.9 704875 5 TBP FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB TAS2R19 TAS2R31 KLRA1P TAS2R14 TAS2R10 TAS2R15P MAGOHB TAS2R20 TAS2R43 KLRC3
GH12H010391 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +697.5 697530 7 FOXA2 ARID4B FEZF1 ATF7 RUNX3 DEK JUNB TSHZ1 ZNF662 KAT8 KLRA1P KLRK1 TAS2R20 KLRC3 KLRC4 KLRC2 LOC101928100 TAS2R31 TAS2R43 MAGOHB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R43 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R43 Gene

Chromosome:
12
Start:
11,091,287 bp from pter
End:
11,092,313 bp from pter
Size:
1,027 bases
Orientation:
Minus strand

Genomic View for TAS2R43 Gene

Genes around TAS2R43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R43 Gene

Proteins for TAS2R43 Gene

  • Protein details for TAS2R43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59537-T2R43_HUMAN
    Recommended name:
    Taste receptor type 2 member 43
    Protein Accession:
    P59537
    Secondary Accessions:
    • P59546
    • Q645X4

    Protein attributes for TAS2R43 Gene

    Size:
    309 amino acids
    Molecular mass:
    35599 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R43 Gene

Post-translational modifications for TAS2R43 Gene

  • Glycosylation at posLast=161161 and Asn176

Other Protein References for TAS2R43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R43 Gene

Domains & Families for TAS2R43 Gene

Gene Families for TAS2R43 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R43 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59537

UniProtKB/Swiss-Prot:

T2R43_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R43: view

Function for TAS2R43 Gene

Molecular function for TAS2R43 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity IDA 16720576
GO:0033038 bitter taste receptor activity IDA 16720576
genes like me logo Genes that share ontologies with TAS2R43: view
genes like me logo Genes that share phenotypes with TAS2R43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAS2R43
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R43 Gene

Localization for TAS2R43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R43 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R43 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC,IBA 16720576
GO:0031514 motile cilium IDA 19628819
genes like me logo Genes that share ontologies with TAS2R43: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R43 Gene

Pathways & Interactions for TAS2R43 Gene

genes like me logo Genes that share pathways with TAS2R43: view

Pathways by source for TAS2R43 Gene

Gene Ontology (GO) - Biological Process for TAS2R43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R43: view

No data available for SIGNOR curated interactions for TAS2R43 Gene

Drugs & Compounds for TAS2R43 Gene

(5) Drugs for TAS2R43 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved, Vet_approved Pharma 7
Diphenidol Approved, Withdrawn Pharma 1
Quinine Approved Pharma Pore Blocker 47
Caffeine Approved Nutra Antagonist A1 and A2B antagonist. CNS stimulant 410
Saccharin Investigational Pharma 0

(11) Additional Compounds for TAS2R43 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acesulfame K
aloin
  • 10-(1',5'-Anhydroglucosyl)aloe-emodin-9-anthrone
  • 10-b-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone, 9CI
  • Aloin a
  • Aloin [ban]
  • Aloinum
8015-61-0
amarogentin
21018-84-8
Arborescin
Arglabin
genes like me logo Genes that share compounds with TAS2R43: view

Transcripts for TAS2R43 Gene

mRNA/cDNA for TAS2R43 Gene

(3) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAS2R43
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R43 Gene

No ASD Table

Relevant External Links for TAS2R43 Gene

GeneLoc Exon Structure for
TAS2R43
ECgene alternative splicing isoforms for
TAS2R43

Expression for TAS2R43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R43 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R43 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of TAS2R43 Gene:

TAS2R43

SOURCE GeneReport for Unigene cluster for TAS2R43 Gene:

Hs.688195

mRNA Expression by UniProt/SwissProt for TAS2R43 Gene:

P59537-T2R43_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.

Evidence on tissue expression from TISSUES for TAS2R43 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TAS2R43: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R43 Gene

Orthologs for TAS2R43 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R43 33
  • 99.14 (n)
TAS2R30 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
ManyToMany
TAS2R46 34
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 34
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 34
  • 51 (a)
ManyToMany
Tas2r136 34
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R24 34
  • 35 (a)
ManyToMany
T2R25 34
  • 35 (a)
ManyToMany
T2R23 34
  • 32 (a)
ManyToMany
Species where no ortholog for TAS2R43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R43 Gene

ENSEMBL:
Gene Tree for TAS2R43 (if available)
TreeFam:
Gene Tree for TAS2R43 (if available)

Paralogs for TAS2R43 Gene

genes like me logo Genes that share paralogs with TAS2R43: view

Variants for TAS2R43 Gene

Sequence variations from dbSNP and Humsavar for TAS2R43 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001066490 -- 11,098,681(+) CCAGA(C/T)TTGTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001080575 -- 11,098,615(+) TGTCT(A/G)AAGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1004515901 -- 11,098,183(+) AGCTG(A/G)CTTCA intron-variant, upstream-variant-2KB
rs1005731202 -- 11,098,942(+) TCCCA(C/T)TCAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1007989955 -- 11,098,270(+) TCTGC(C/T)GGGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TAS2R43 Gene

Variant ID Type Subtype PubMed ID
dgv1375n100 CNV loss 25217958
dgv1377n100 CNV gain 25217958
dgv1378n100 CNV loss 25217958
dgv172e201 CNV deletion 23290073
dgv173e201 CNV deletion 23290073
dgv2363n54 CNV gain 21841781
dgv2364n54 CNV gain+loss 21841781
dgv2365n54 CNV gain 21841781
dgv2366n54 CNV gain+loss 21841781
dgv2367n54 CNV loss 21841781
dgv2368n54 CNV loss 21841781
dgv2369n54 CNV gain 21841781
dgv2370n54 CNV gain+loss 21841781
dgv2371n54 CNV loss 21841781
dgv2372n54 CNV loss 21841781
dgv268e199 CNV deletion 23128226
dgv271n67 CNV loss 20364138
dgv43e19 CNV loss 19470904
dgv453e212 CNV gain 25503493
dgv454e212 CNV gain 25503493
dgv455e212 CNV loss 25503493
dgv456e212 CNV loss 25503493
dgv458e212 CNV gain 25503493
dgv459e212 CNV loss 25503493
esv23283 CNV loss 19812545
esv2421447 CNV deletion 20811451
esv2421542 CNV deletion 20811451
esv2665068 CNV deletion 23128226
esv2670207 CNV deletion 23128226
esv2745549 CNV deletion 23290073
esv2745550 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv2760999 CNV gain+loss 21179565
esv2874902 CNV deletion 24192839
esv3628561 CNV loss 21293372
esv3628562 CNV gain 21293372
nsv1038277 CNV loss 25217958
nsv1038709 CNV loss 25217958
nsv1050050 CNV loss 25217958
nsv1070093 CNV deletion 25765185
nsv1112616 CNV deletion 24896259
nsv1159979 CNV deletion 26073780
nsv428272 CNV gain+loss 18775914
nsv436149 CNV deletion 17901297
nsv471366 CNV gain 19718026
nsv511013 OTHER complex 20534489
nsv557489 CNV loss 21841781
nsv557497 CNV gain 21841781
nsv557522 CNV loss 21841781
nsv8917 CNV loss 18304495
nsv973028 CNV duplication 23825009
nsv977132 CNV duplication 23825009

Variation tolerance for TAS2R43 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R43 Gene

Human Gene Mutation Database (HGMD)
TAS2R43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R43 Gene

Disorders for TAS2R43 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAS2R43 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
balkan nephropathy
  • balkan endemic nephropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TAS2R43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R43
genes like me logo Genes that share disorders with TAS2R43: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS2R43 Gene

Publications for TAS2R43 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. (PMID: 12379855) Bufe B … Meyerhof W (Nature genetics 2002) 2 3 4 60
  2. Motile cilia of human airway epithelia are chemosensory. (PMID: 19628819) Shah AS … Welsh MJ (Science (New York, N.Y.) 2009) 3 4 60
  3. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Bitter taste receptors for saccharin and acesulfame K. (PMID: 15537898) Kuhn C … Meyerhof W (The Journal of neuroscience : the official journal of the Society for Neuroscience 2004) 3 4 60

Products for TAS2R43 Gene

Sources for TAS2R43 Gene

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