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Aliases for TAS2R43 Gene

Aliases for TAS2R43 Gene

  • Taste Receptor, Type 2, Member 43 2 3
  • Taste Receptor Type 2 Member 52 3 4
  • T2R43 3 4
  • T2R52 3 4

External Ids for TAS2R43 Gene

Previous GeneCards Identifiers for TAS2R43 Gene

  • GC00U991252
  • GC12M011144
  • GC12M011135
  • GC12M9J0020
  • GC12M011215
  • GC12M011243

Summaries for TAS2R43 Gene

Entrez Gene Summary for TAS2R43 Gene

  • TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

GeneCards Summary for TAS2R43 Gene

TAS2R43 (Taste Receptor, Type 2, Member 43) is a Protein Coding gene. Diseases associated with TAS2R43 include balkan nephropathy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R43 Gene

  • Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).

Gene Wiki entry for TAS2R43 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R43 Gene

Genomics for TAS2R43 Gene

Regulatory Elements for TAS2R43 Gene

Genomic Location for TAS2R43 Gene

Chromosome:
12
Start:
11,091,287 bp from pter
End:
11,134,244 bp from pter
Size:
42,958 bases
Orientation:
Minus strand

Genomic View for TAS2R43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R43 Gene

Proteins for TAS2R43 Gene

  • Protein details for TAS2R43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59537-T2R43_HUMAN
    Recommended name:
    Taste receptor type 2 member 43
    Protein Accession:
    P59537
    Secondary Accessions:
    • P59546
    • Q645X4

    Protein attributes for TAS2R43 Gene

    Size:
    309 amino acids
    Molecular mass:
    35599 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R43 Gene

Proteomics data for TAS2R43 Gene at MOPED

Post-translational modifications for TAS2R43 Gene

  • Glycosylation at Asn 161 and Asn 176

Other Protein References for TAS2R43 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAS2R43 Gene

Domains & Families for TAS2R43 Gene

Gene Families for TAS2R43 Gene

Protein Domains for TAS2R43 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59537

UniProtKB/Swiss-Prot:

T2R43_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R43: view

Function for TAS2R43 Gene

Molecular function for TAS2R43 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity IDA 16720576
GO:0033038 bitter taste receptor activity IDA 16720576
genes like me logo Genes that share ontologies with TAS2R43: view

Phenotypes for TAS2R43 Gene

GenomeRNAi human phenotypes for TAS2R43:
genes like me logo Genes that share phenotypes with TAS2R43: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R43

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R43 Gene

Localization for TAS2R43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R43 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R43 Gene COMPARTMENTS Subcellular localization image for TAS2R43 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 16720576
GO:0031514 motile cilium IDA 19628819
GO:0060170 ciliary membrane IEA --
genes like me logo Genes that share ontologies with TAS2R43: view

Pathways & Interactions for TAS2R43 Gene

genes like me logo Genes that share pathways with TAS2R43: view

Pathways by source for TAS2R43 Gene

1 KEGG pathway for TAS2R43 Gene

Interacting Proteins for TAS2R43 Gene

Gene Ontology (GO) - Biological Process for TAS2R43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R43: view

No data available for SIGNOR curated interactions for TAS2R43 Gene

Drugs & Compounds for TAS2R43 Gene

(4) Drugs for TAS2R43 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma 6
Diphenidol Approved, Withdrawn Pharma 1
Quinine Approved Pharma Inhibition, Inhibitor 38
Caffeine Approved Nutra Activator 317

(12) Additional Compounds for TAS2R43 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acesulfame K
aloin
  • 10-(1',5'-Anhydroglucosyl)aloe-emodin-9-anthrone
  • 10-b-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone, 9CI
  • Aloin a
  • Aloin [ban]
  • Aloinum
8015-61-0
amarogentin
21018-84-8
Arborescin
Arglabin
genes like me logo Genes that share compounds with TAS2R43: view

Transcripts for TAS2R43 Gene

mRNA/cDNA for TAS2R43 Gene

(3) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R43

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R43 Gene

No ASD Table

Relevant External Links for TAS2R43 Gene

GeneLoc Exon Structure for
TAS2R43
ECgene alternative splicing isoforms for
TAS2R43

Expression for TAS2R43 Gene

mRNA expression in normal human tissues for TAS2R43 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R43 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

SOURCE GeneReport for Unigene cluster for TAS2R43 Gene Hs.688195

mRNA Expression by UniProt/SwissProt for TAS2R43 Gene

P59537-T2R43_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.
genes like me logo Genes that share expression patterns with TAS2R43: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R43 Gene

Orthologs for TAS2R43 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R43 35
  • 99.14 (n)
  • 98.71 (a)
TAS2R30 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
ManyToMany
TAS2R46 36
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 36
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 32 (a)
ManyToMany
T2R24 36
  • 35 (a)
ManyToMany
T2R25 36
  • 35 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r120 36
  • 51 (a)
ManyToMany
Tas2r136 36
  • 41 (a)
ManyToMany
Species with no ortholog for TAS2R43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R43 Gene

ENSEMBL:
Gene Tree for TAS2R43 (if available)
TreeFam:
Gene Tree for TAS2R43 (if available)

Paralogs for TAS2R43 Gene

genes like me logo Genes that share paralogs with TAS2R43: view

Variants for TAS2R43 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAS2R43 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv898780 CNV Loss 21882294
esv2670207 CNV Deletion 23128226
nsv8917 CNV Loss 18304495
dgv191e201 CNV Deletion 23290073
nsv436149 CNV Deletion 17901297
nsv898781 CNV Loss 21882294
nsv898782 CNV Loss 21882294
dgv1374n71 CNV Loss 21882294
esv2665068 CNV Deletion 23128226
esv2745549 CNV Deletion 23290073
dgv36e19 CNV Loss 19470904
esv2745550 CNV Deletion 23290073
dgv271n67 CNV Loss 20364138
esv23283 CNV Loss 19812545
esv2421542 CNV Deletion 20811451
dgv268e199 CNV Deletion 23128226
nsv511013 CNV Complex 20534489
esv2421447 CNV Deletion 20811451
nsv471366 CNV Duplication 19718026
dgv192e201 CNV Deletion 23290073

Variation tolerance for TAS2R43 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R43 Gene

HapMap Linkage Disequilibrium report
TAS2R43
Human Gene Mutation Database (HGMD)
TAS2R43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TAS2R43 Gene

Disorders for TAS2R43 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAS2R43 Gene - From: DISEASES

Disorder Aliases PubMed IDs
balkan nephropathy
  • balkan endemic nephropathy
- elite association

Relevant External Links for TAS2R43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R43
genes like me logo Genes that share disorders with TAS2R43: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS2R43 Gene

Publications for TAS2R43 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 67
  2. Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues. (PMID: 22397221) Hirai R. … Ikeda M. (Ann. Otol. Rhinol. Laryngol. 2012) 67
  3. Extraoral bitter taste receptors as mediators of off-target drug effects. (PMID: 22964302) Clark A.A. … Munger S.D. (FASEB J. 2012) 67
  4. Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN). (PMID: 23050764) Wooding S.P. … Toncheva D. (BMC Med. Genet. 2012) 67
  5. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 67

Products for TAS2R43 Gene

Sources for TAS2R43 Gene

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