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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R43 Gene

protein-coding   GIFtS: 44
GCID: GC12M011243

Taste Receptor, Type 2, Member 43

  Search for TAS2R43
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 431 2
T2R522 3 5
Taste Receptor Type 2 Member 522 3
T2R432 3
Taste Receptor Type 2 Member 432

External Ids:    HGNC: 188751   Entrez Gene: 2592892   Ensembl: ENSG000002553747   OMIM: 6126685   UniProtKB: P595373   

Export aliases for TAS2R43 gene to outside databases

Previous GC identifers: GC00U991252 GC12M011144 GC12M011135 GC12M9J0020 GC12M011215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R43 Gene:
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells
and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002
(PubMed 12584440)). For further information on TAS2Rs, see MIM 604791.(supplied by OMIM, Mar 2009)

GeneCards Summary for TAS2R43 Gene: 
TAS2R43 (taste receptor, type 2, member 43) is a protein-coding gene. Among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include bitter taste receptor activity and taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537
Function: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the
gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the
sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds
increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as
chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the
airways (By similarity)

Gene Wiki entry for TAS2R43 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018923.2  NC_000012.11  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R43 gene promoter:
         Sox5   FOXO3   POU2F2   FOXO3b   SRY   POU2F1   FOXO4   POU2F1a   FOXO3a   
         Other transcription factors

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   Search SABiosciences Chromatin IP Primers for TAS2R43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

TAS2R43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R43 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011243:  view genomic region     (about GC identifiers)

Start:
11,243,886 bp from pter      End:
11,244,912 bp from pter
Size:
1,027 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571047 291,856-292,882      Chr12-,NW_003571050 290,014-291,040     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537 (See protein sequence)
Recommended Name: Taste receptor type 2 member 43  
Size: 309 amino acids; 35599 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway
epithelial cells, localizes to motile cilia
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: P59546 Q645X4

Explore the universe of human proteins at neXtProt for TAS2R43: NX_P59537

TAS2R43 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_795365.2  
ENSEMBL proteins: 
 ENSP00000431719  
Reactome Protein details: P59537
Human Recombinant Protein Products for TAS2R43: 
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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IC16720576
GO:0031514motile cilium IDA19628819
GO:0060170cilium membrane IEA--

TAS2R43 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TASNR: GPCR / Unclassified : Taste receptors
TAS2R: Taste receptors / Type 2

IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R43 
Taste 2 receptors

1 InterPro protein domain:
 IPR007960 TAS2_rcpt

Graphical View of Domain Structure for InterPro Entry P59537

ProtoNet protein and cluster: P59537

UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537
Similarity: Belongs to the G-protein coupled receptor T2R family


TAS2R43 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T2R43_HUMAN, P59537
Function: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the
gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the
sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds
increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as
chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the
airways (By similarity)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0008527taste receptor activity IDA16720576
GO:0033038bitter taste receptor activity IDA16720576
     
TAS2R43 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TAS2R43 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
Taste transduction0.45
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71
G alpha (i) signalling events0.46
4Sweet Taste Signaling
Bitter Taste Signaling0.44

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R43
    Bitter Taste Signaling

5/6        Reactome Pathways for TAS2R43 (see all 6)
    GPCR downstream signaling
Signal Transduction
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by GPCR
G alpha (i) signalling events


1         Kegg Pathway  (Kegg details for TAS2R43):
    Taste transduction


TAS2R43 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R43

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA16720576
GO:0007186G-protein coupled receptor signaling pathway IC16720576
GO:0050909sensory perception of taste ----

TAS2R43 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS2R43 (T2R43)

10/16 BitterDB Bitter Compounds for TAS2R43 (see all 16) About this table
CompoundSMILES CAS #
acesulfame K[K+].CC1=CC(=NS(=O)(=O)O1)[O-]--
aloinOC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)[C@@H]2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc248015-61-0
amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
ArglabinCC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13--
Aristolochic acidCOc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-]--
CaffeineCN1C(=O)N(C)c2ncn(C)c2C1=O58-08-2
chloramphenicolOC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-]--
cromolynOC(COc1ccc2OC(=CC(=O)c2c1)C(=O)O)COc3cccc4OC(=CC(=O)c34)C(=O)O--
denatonium benzoateCC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc33734-33-6


Search CenterWatch for drugs/clinical trials and news about TAS2R43 / T2R43

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAS2R43 gene: 
NM_176884.2  

Unigene Cluster for TAS2R43:

Taste receptor, type 2, member 43
Hs.688195
Unigene Representative Sequence: NM_176884
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000531678(uc001qzq.1)
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Additional mRNA sequence: 

BC101155.1 BC117423.1 

2 DOTS entries:

DT.86859104  DT.121204118 

1 AceView cDNA sequence:

NM_176884 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAS2R43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTGCAAAG
TAS2R43 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.688195

UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
gustducin-positive cells. Expressed in airway epithelia

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for TAS2R43 (if available)
TreeFam Gene Tree for TAS2R43 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TAS2R43 gene
TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R142  TAS2R392  TAS2R382  
TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R82  
TAS2R202  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
18/51 SIMAP similar genes for TAS2R43 using alignment to 1 protein entry:     T2R43_HUMAN(see all similar genes):
Hosa(Biaka)-T2R43    Hosa(Adygei)-T2R46    Hosa(Biaka)-T2R46    TAS2R31    TAS2R46    Hosa(Japanese)-T2R45
TAS2R45    Hosa(Biaka)-T2R47    TAS2R30    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R48    Hosa(Japanese)-T2R48
TAS2R19    Hosa(Biaka)-T2R49    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R50    TAS2R50    Hosa(Adygei)-T2R49

TAS2R43 for paralogs           About GeneDecksing


5/6 Pseudogenes.org Pseudogenes for TAS2R43 (see all 6)
PGOHUM00000239336 PGOHUM00000257936 PGOHUM00000262522 PGOHUM00000262527 PGOHUM00000262618


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

1 SNPs in TAS2R43 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs357980591,2
C--11251976(+) AAGAT-/GCCGCCGA 1 -- cds10--------

HapMap Linkage Disequilibrium report for TAS2R43 (11243886 - 11244912 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/23 variations for TAS2R43 (see all 23):    About this table     
Variant IDTypeSubtypePubMed ID
esv2745549CNV Deletion23290073
dgv192e201CNV Deletion23290073
esv2421447CNV Deletion20811451
dgv268e199CNV Deletion23128226
esv2421542CNV Deletion20811451
esv2745550CNV Deletion23290073
nsv436149CNV Deletion17901297
dgv191e201CNV Deletion23290073
esv2665068CNV Deletion23128226
esv2670207CNV Deletion23128226


Human Gene Mutation Database (HGMD): TAS2R43
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAS2R43 for disorders           About MalaCards
OMIM gene information: 612668    OMIM disorders: --


TAS2R43 for disorders           About GeneDecksing


Export disorders for TAS2R43 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAS2R43 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TAS2R43)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
  2. Motile cilia of human airway epithelia are chemosensory. (PubMed id 19628819)1, 2 Shah A.S.... Welsh M.J. (2009)
  3. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
  4. Bitter taste receptors for saccharin and acesulfame K. (PubMed id 15537898)1, 2 Kuhn C.... Meyerhof W. (2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
  7. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
  8. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2 Conte C.... Andres-Barquin P.J. (2002)
  9. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
  10. Patients with phantogeusia show increased expression o f T2R taste receptor genes in their tongues. (PubMed id 22397221)1 Hirai R....Ikeda M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 259289 HGNC: 18875 AceView: TAS2R43.1 Ensembl:ENSG00000255374 euGenes: HUgn259289
ECgene: TAS2R43 Kegg: 259289 H-InvDB: TAS2R43

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TAS2R43 Pharmacogenomics, SNPs, Pathways
Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt119.shtml

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TAS2R43 gene:
Search GeneIP for patents involving TAS2R43

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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