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TAS2R43 Gene

protein-coding   GIFtS: 42
GCID: GC12M011243

Taste Receptor, Type 2, Member 43

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 2, Member 431 2
T2R522 3 5
Taste Receptor Type 2 Member 522 3
T2R432 3
Taste Receptor Type 2 Member 432

External Ids:    HGNC: 188751   Entrez Gene: 2592892   Ensembl: ENSG000002553747   OMIM: 6126685   UniProtKB: P595373   

Export aliases for TAS2R43 gene to outside databases

Previous GC identifers: GC00U991252 GC12M011144 GC12M011135 GC12M9J0020 GC12M011215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAS2R43 Gene:
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells
and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002
(PubMed 12584440)). For further information on TAS2Rs, see MIM 604791.(supplied by OMIM, Mar 2009)

GeneCards Summary for TAS2R43 Gene:
TAS2R43 (taste receptor, type 2, member 43) is a protein-coding gene. GO annotations related to this gene include bitter taste receptor activity and taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537
Function: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the
gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the
sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds
increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as
chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the
airways (By similarity)

Gene Wiki entry for TAS2R43 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R43 gene promoter:
         Sox5   FOXO3   POU2F2   FOXO3b   SRY   POU2F1   FOXO4   POU2F1a   FOXO3a   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

TAS2R43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R43 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011243:  view genomic region     (about GC identifiers)

Start:
11,243,886 bp from pter      End:
11,244,912 bp from pter
Size:
1,027 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571047 291,856-292,882      Chr12-,NW_003571050 290,014-291,040     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537 (See protein sequence)
Recommended Name: Taste receptor type 2 member 43  
Size: 309 amino acids; 35599 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: P59546 Q645X4

Explore the universe of human proteins at neXtProt for TAS2R43: NX_P59537

Post-translational modifications: 

  • Glycosylation2 at Asn161, Asn176
  • REFSEQ proteins: NP_795365.2  
    ENSEMBL proteins: 
     ENSP00000431719  
    Reactome Protein details: P59537

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R43
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59537

    ProtoNet protein and cluster: P59537

    UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537
    Similarity: Belongs to the G-protein coupled receptor T2R family


    Find genes that share domains with TAS2R43           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R43_HUMAN, P59537
    Function: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the
    gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the
    sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds
    increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as
    chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the
    airways (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0008527taste receptor activity IDA16720576
    GO:0033038bitter taste receptor activity IDA16720576
         
    Find genes that share ontologies with TAS2R43           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2R43_HUMAN, P59537: Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway
    epithelial cells, localizes to motile cilia

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IC16720576
    GO:0031514motile cilium IDA19628819
    GO:0060170ciliary membrane IEA--

    Find genes that share ontologies with TAS2R43           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS2R43 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44


    Find genes that share SuperPaths with TAS2R43           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TAS2R43
        Bitter Taste Signaling

    2 Reactome Pathways for TAS2R43
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R43):
        Taste transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R43
    Interactions:

        Search GeneGlobe Interaction Network for TAS2R43

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA16720576
    GO:0007186G-protein coupled receptor signaling pathway IC16720576
    GO:0050909sensory perception of taste ----

    Find genes that share ontologies with TAS2R43           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS2R43 (T2R43)

    Selected BitterDB Bitter Compounds for TAS2R43 (see all 16)    About this table
    CompoundSMILES CAS #
    acesulfame K[K+].CC1=CC(=NS(=O)(=O)O1)[O-]--
    aloinOC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)[C@@H]2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc248015-61-0
    amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
    ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
    ArglabinCC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13--
    Aristolochic acidCOc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-]--
    CaffeineCN1C(=O)N(C)c2ncn(C)c2C1=O58-08-2
    chloramphenicolOC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-]--
    cromolynOC(COc1ccc2OC(=CC(=O)c2c1)C(=O)O)COc3cccc4OC(=CC(=O)c34)C(=O)O--
    denatonium benzoateCC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc33734-33-6




    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAS2R43 gene: 
    NM_176884.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000531678(uc001qzq.1)
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    1 AceView cDNA sequence:

    NM_176884 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAS2R43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGCAAAG
    TAS2R43 Expression
    About this image

    TAS2R43 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells. Expressed in airway epithelia

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for TAS2R43 (if available)
    TreeFam Gene Tree for TAS2R43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS2R43 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R142  TAS2R392  TAS2R382  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R82  
    TAS2R202  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    Selected SIMAP similar genes for TAS2R43 using alignment to 1 protein entry:     T2R43_HUMAN(see all similar genes):
    Hosa(Biaka)-T2R43    Hosa(Adygei)-T2R46    Hosa(Biaka)-T2R46    TAS2R31    TAS2R46    Hosa(Japanese)-T2R45
    TAS2R45    Hosa(Biaka)-T2R47    TAS2R30    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R48    Hosa(Japanese)-T2R48
    TAS2R19    Hosa(Biaka)-T2R49    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R50    TAS2R50    Hosa(Adygei)-T2R49

    Find genes that share paralogs with TAS2R43           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TAS2R43 (see all 6)
    PGOHUM00000239336 PGOHUM00000257936 PGOHUM00000262522 PGOHUM00000262527 PGOHUM00000262618


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for TAS2R43    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357980591,2
    C--11251976(+) AAGAT-/GCCGCCGA 1 -- cds10--------

    HapMap Linkage Disequilibrium report for TAS2R43 (11243886 - 11244912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TAS2R43 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745549CNV Deletion23290073
    dgv192e201CNV Deletion23290073
    esv2421447CNV Deletion20811451
    dgv268e199CNV Deletion23128226
    esv2421542CNV Deletion20811451
    esv2745550CNV Deletion23290073
    nsv436149CNV Deletion17901297
    dgv191e201CNV Deletion23290073
    esv2665068CNV Deletion23128226
    esv2670207CNV Deletion23128226

    Human Gene Mutation Database (HGMD): TAS2R43
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612668    OMIM disorders: --


    Find genes that share disorders with TAS2R43           About GenesLikeMe


    Export disorders for TAS2R43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS2R43 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TAS2R43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (Nat. Genet. 2002)
    2. Motile cilia of human airway epithelia are chemosensory. (PubMed id 19628819)1, 2 Shah A.S.... Welsh M.J. (Science 2009)
    3. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
    4. Bitter taste receptors for saccharin and acesulfame K. (PubMed id 15537898)1, 2 Kuhn C.... Meyerhof W. (J. Neurosci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (Cell 2003)
    7. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)
    8. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2 Conte C.... Andres-Barquin P.J. (Cytogenet. Genome Res. 2002)
    9. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (J. Biol. Chem. 2002)
    10. Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues. (PubMed id 22397221)1 Hirai R....Ikeda M. (Ann. Otol. Rhinol. Laryngol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 259289 HGNC: 18875 AceView: TAS2R43.1 Ensembl:ENSG00000255374 euGenes: HUgn259289
    ECgene: TAS2R43 Kegg: 259289 H-InvDB: TAS2R43

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS2R43 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/119

    (Patent information from GeneIP,
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    Patent Information for TAS2R43 gene:
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