TAS2R43 Gene
protein-coding GIFtS: 43
GCID: GC12M011243
|
|
taste receptor, type 2, member 43
| |
Aliases
for TAS2R43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 2, Member 431 2 | | T2R521 2 3 5 | | Taste Receptor Type 2 Member 522 3 | | T2R432 3 | | Taste Receptor Type 2 Member 432 |
Export aliases for TAS2R43 gene to outside databasesPrevious GC identifers: GC00U991252 GC12M011144 GC12M011135 GC12M9J0020 GC12M011215 |
Summaries
for TAS2R43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R43:
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells andmediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 (PubMed12584440)). For further information on TAS2Rs, see MIM 604791.(supplied by OMIM, Mar 2009)
UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537Function: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and thegastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by thesulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compoundsincreases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensoryreceptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity)
Gene Wiki entry for TAS2R43
|
Genomic Views
for TAS2R43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R43 gene promoter:
Sox5 FOXO3 POU2F2 FOXO3b SRY POU2F1 FOXO4 POU2F1a FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.2TAS2R43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M011243: view genomic region
(about GC identifiers)
Start:
|
11,243,886 bp from pter |
End:
|
11,244,912 bp from pter |
Size:
|
1,027 bases |
Orientation:
|
minus strand |
|
Proteins
for TAS2R43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537 (See
protein sequence)Recommended Name: Taste receptor type 2 member 43 Size: 309 amino acids; 35599 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airwayepithelial cells, localizes to motile cilia
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells candiscriminate among bitter stimuli
Secondary accessions: P59546 Q645X4Explore the universe of human proteins at neXtProt for TAS2R43: NX_P59537
TAS2R43 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_795365.2
ENSEMBL proteins: ENSP00000431719
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TAS2R43 for ontologies About GeneDecksing
TAS2R43 Antibody Products:
Assay Products for TAS2R43: |
Protein
Domains /
Families
for TAS2R43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R43 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P59537ProtoNet protein and cluster: P59537 UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537Similarity: Belongs to the G-protein coupled receptor T2R family |
Function
for TAS2R43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537Function: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and thegastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by thesulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compoundsincreases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensoryreceptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R43
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TAS2R43 for ontologies About GeneDecksing
|
Pathways & Interactions
for TAS2R43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Taste transduction | | | 2 | Sweet Taste Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R43
1 
Kegg Pathway (Kegg details for TAS2R43):
TAS2R43 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R43
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste |
IDA | 16720576 | | GO:0007186 | G-protein coupled receptor signaling pathway |
IC | 16720576 |
TAS2R43 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS2R43
10/16 BitterDB Bitter Compounds for TAS2R43 (see all 16)
| Compound | SMILES |
CAS
# |
|---|
| acesulfame K | [K+].CC1=CC(=NS(=O)(=O)O1)[O-] | -- | | aloin | OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)[C@@H]2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc24 | 8015-61-0 | | amarogentin | OC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O | 21018-84-8 | | Arborescin | CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O | -- | | Arglabin | CC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13 | -- | | Aristolochic acid | COc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-] | -- | | Caffeine | CN1C(=O)N(C)c2ncn(C)c2C1=O | 58-08-2 | | chloramphenicol | OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-] | -- | | cromolyn | OC(COc1ccc2OC(=CC(=O)c2c1)C(=O)O)COc3cccc4OC(=CC(=O)c34)C(=O)O | -- | | denatonium benzoate | CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 | 3734-33-6 |
About this table
Search CenterWatch for drugs/clinical trials and news about TAS2R43 / T2R43
|
Transcripts
for TAS2R43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS2R43 gene: NM_176884.2 Unigene Cluster for TAS2R43: Taste receptor, type 2, member 43 Hs.688195 Unigene Representative Sequence: NM_1768841 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000531678(uc001qzq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R43
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R43
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS2R43 (NM_176884) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R43 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TAS2R43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R43 |
Additional cDNA sequence: BC101155.1 BC117423.1 2 DOTS entries: DT.86859104 DT.121204118 1 AceView cDNA sequence: NM_176884
GeneLoc Exon Structure
|
Expression
for TAS2R43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS2R43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGCAAAG
About this image
SOURCE GeneReport for Unigene cluster: Hs.688195
UniProtKB/Swiss-Prot: T2R43_HUMAN, P59537Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positivecells. Expressed in airway epithelia
SABiosciences Custom PCR Arrays for TAS2R43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TAS2R43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R43 |
Orthologs
for TAS2R43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAS2R43 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for TAS2R43 (if available)
TreeFam Gene Tree for TAS2R43 (if available) |
Paralogs
for TAS2R43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAS2R43 gene
- TAS2R52 TAS2R412 TAS2R462 TAS2R162 TAS2R32 TAS2R142 TAS2R392 TAS2R382
- TAS2R422 TAS2R92 TAS2R42 TAS2R302 TAS2R12 TAS2R192 TAS2R72 TAS2R202
- TAS2R82 TAS2R132 TAS2R402 TAS2R102 TAS2R502 TAS2R602 TAS2R312
18/55 SIMAP similar genes for TAS2R43 using alignment to 1 protein entry: T2R43_HUMAN(see all similar genes):Hosa(Biaka)-T2R43 Hosa(Adygei)-T2R46 Hosa(Biaka)-T2R46 TAS2R31 TAS2R46 Hosa(Japanese)-T2R45
TAS2R45 Hosa(Biaka)-T2R47 TAS2R30 Hosa(Adygei)-T2R50 Hosa(Biaka)-T2R48 Hosa(Japanese)-T2R48
TAS2R19 Hosa(Biaka)-T2R49 Hosa(Biaka)-T2R50 Hosa(Japanese)-T2R50 TAS2R50 Hosa(Adygei)-T2R49
TAS2R43 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for TAS2R43 (see all 6)
PGOHUM00000239336 PGOHUM00000257936 PGOHUM00000262522 PGOHUM00000262527 PGOHUM00000262618
|
Genomic Variants
for TAS2R43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAS2R43 (11243886 - 11244912 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TAS2R43
7 CNVs: 22928 86213 66140 3875 31858 75948 75946
Human Gene Mutation Database (HGMD): TAS2R43
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TAS2R43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TAS2R43 for disorders About MalaCards
TAS2R43 for disorders About GeneDecksing
OMIM gene information: 612668
OMIM disorders: --
Export disorders for TAS2R43 gene to outside databases
|
Publications
for TAS2R43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS2R43 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with TAS2R43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
- Motile cilia of human airway epithelia are chemosensory. (PubMed id 19628819)1, 2 Shah A.S.... Welsh M.J. (2009)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- Bitter taste receptors for saccharin and acesulfame K. (PubMed id 15537898)1, 2 Kuhn C.... Meyerhof W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2 Conte C.... Andres-Barquin P.J. (2002)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Patients with phantogeusia show increased expression o f T2R taste receptor genes in their tongues. (PubMed id 22397221)1 Hirai R....Ikeda M. (2012)
|
External Searches for TAS2R43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS2R43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS2R43 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt119.shtml |
|
| | |
About This Section
| Patent Information for TAS2R43 gene:
Search GeneIP for patents involving TAS2R43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAS2R43 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R43 |
| |
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