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Aliases for TAS2R42 Gene

Aliases for TAS2R42 Gene

  • Taste 2 Receptor Member 42 2 3 5
  • Taste Receptor, Type 2, Member 42 2 3
  • Taste Receptor Type 2 Member 55 3 4
  • TAS2R55 3 4
  • T2R42 3 4
  • T2R55 3 4
  • Candidate Taste Receptor HT2R55 3
  • T2R24 3

External Ids for TAS2R42 Gene

Previous GeneCards Identifiers for TAS2R42 Gene

  • GC00U991251
  • GC12M011231
  • GC12M011338
  • GC12M011101

Summaries for TAS2R42 Gene

GeneCards Summary for TAS2R42 Gene

TAS2R42 (Taste 2 Receptor Member 42) is a Protein Coding gene. Among its related pathways are Taste transduction and Sweet Taste Signaling. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot for TAS2R42 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R42 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R42 Gene

Genomics for TAS2R42 Gene

Regulatory Elements for TAS2R42 Gene

Enhancers for TAS2R42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R42 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R42 Gene

Chromosome:
12
Start:
11,185,993 bp from pter
End:
11,186,937 bp from pter
Size:
945 bases
Orientation:
Minus strand

Genomic View for TAS2R42 Gene

Genes around TAS2R42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R42 Gene

Proteins for TAS2R42 Gene

  • Protein details for TAS2R42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTR8-T2R42_HUMAN
    Recommended name:
    Taste receptor type 2 member 42
    Protein Accession:
    Q7RTR8
    Secondary Accessions:
    • A2RRP4
    • Q645X0

    Protein attributes for TAS2R42 Gene

    Size:
    314 amino acids
    Molecular mass:
    36195 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R42 Gene

Proteomics data for TAS2R42 Gene at MOPED

Post-translational modifications for TAS2R42 Gene

Other Protein References for TAS2R42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R42 Gene

Domains & Families for TAS2R42 Gene

Gene Families for TAS2R42 Gene

Protein Domains for TAS2R42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTR8

UniProtKB/Swiss-Prot:

T2R42_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R42: view

Function for TAS2R42 Gene

Molecular function for TAS2R42 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
genes like me logo Genes that share phenotypes with TAS2R42: view

Animal Models for TAS2R42 Gene

MGI Knock Outs for TAS2R42:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R42 Gene

Localization for TAS2R42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R42 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R42 Gene COMPARTMENTS Subcellular localization image for TAS2R42 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TAS2R42 Gene

Pathways & Interactions for TAS2R42 Gene

genes like me logo Genes that share pathways with TAS2R42: view

Pathways by source for TAS2R42 Gene

Interacting Proteins for TAS2R42 Gene

Gene Ontology (GO) - Biological Process for TAS2R42 Gene

None

No data available for SIGNOR curated interactions for TAS2R42 Gene

Drugs & Compounds for TAS2R42 Gene

No Compound Related Data Available

Transcripts for TAS2R42 Gene

mRNA/cDNA for TAS2R42 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R42 Gene

No ASD Table

Relevant External Links for TAS2R42 Gene

GeneLoc Exon Structure for
TAS2R42
ECgene alternative splicing isoforms for
TAS2R42

Expression for TAS2R42 Gene

mRNA expression in normal human tissues for TAS2R42 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R42 Gene



SOURCE GeneReport for Unigene cluster for TAS2R42 Gene Hs.553716

genes like me logo Genes that share expression patterns with TAS2R42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TAS2R42 Gene

Orthologs for TAS2R42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R42 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TAS2R42 35
  • 78.24 (n)
  • 63.02 (a)
TAS2R42 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r131 35
  • 66.44 (n)
  • 50.52 (a)
Tas2r131 16
Tas2r131 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAS2R42 35
  • 98.62 (n)
  • 97.12 (a)
rat
(Rattus norvegicus)
Mammalia Tas2r145 35
  • 65.87 (n)
  • 50.68 (a)
cow
(Bos Taurus)
Mammalia TAS2R42 36
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 33 (a)
ManyToMany
T2R24 36
  • 35 (a)
ManyToMany
T2R25 36
  • 35 (a)
ManyToMany
Species with no ortholog for TAS2R42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R42 Gene

ENSEMBL:
Gene Tree for TAS2R42 (if available)
TreeFam:
Gene Tree for TAS2R42 (if available)

Paralogs for TAS2R42 Gene

genes like me logo Genes that share paralogs with TAS2R42: view

Variants for TAS2R42 Gene

Sequence variations from dbSNP and Humsavar for TAS2R42 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs5020531 - 11,186,351(-) TCTGT(C/T)CCTGA reference, missense
rs1451772 - 11,186,144(+) TTATG(C/T)ACTTG reference, missense
rs35969491 - 11,186,414(+) TATCA(A/T)AGAGA reference, missense
rs1669413 - 11,186,175(+) TATCC(A/C)ATTGG reference, missense
rs1669412 - 11,186,063(+) TCTGT(C/T)GCAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R42 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
dgv1374n71 CNV Loss 21882294
nsv8918 CNV Gain 18304495

Variation tolerance for TAS2R42 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R42 Gene

HapMap Linkage Disequilibrium report
TAS2R42
Human Gene Mutation Database (HGMD)
TAS2R42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R42 Gene

Disorders for TAS2R42 Gene

Relevant External Links for TAS2R42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R42

No disorders were found for TAS2R42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R42 Gene

Publications for TAS2R42 Gene

  1. Adaptive diversification of bitter taste receptor genes in mammalian evolution. (PMID: 12679530) Shi P. … Zhang Y.-P. (Mol. Biol. Evol. 2003) 2 3 4 67
  2. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. (PMID: 23632330) Thalmann S. … Meyerhof W. (Biochem. Biophys. Res. Commun. 2013) 3
  3. Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues. (PMID: 22397221) Hirai R. … Ikeda M. (Ann. Otol. Rhinol. Laryngol. 2012) 3
  4. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3

Products for TAS2R42 Gene

Sources for TAS2R42 Gene

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