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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R42 Gene

protein-coding   GIFtS: 44
GCID: GC12M011338

Taste Receptor, Type 2, Member 42

  Search for TAS2R42
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 421 2     T2R242
Taste Receptor Type 2 Member 552 3     Candidate Taste Receptor HT2R552
T2R422 3     hT2R552
T2R552 3     Taste Receptor T2R552
TAS2R552 3     Taste Receptor Type 2 Member 422

External Ids:    HGNC: 188881   Entrez Gene: 3531642   Ensembl: ENSG000001861367   OMIM: 6139665   UniProtKB: Q7RTR83   

Export aliases for TAS2R42 gene to outside databases

Previous GC identifers: GC00U991251 GC12M011231 GC12M011101


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TAS2R42 Gene: 
TAS2R42 (taste receptor, type 2, member 42) is a protein-coding gene. Among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R42_HUMAN, Q7RTR8
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R42 gene promoter:
         MyoD   STAT5A   NF-AT   Evi-1   NF-AT4   NF-AT2   POU2F1   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TAS2R42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

TAS2R42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R42 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011338:  view genomic region     (about GC identifiers)

Start:
11,338,599 bp from pter      End:
11,339,543 bp from pter
Size:
945 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R42_HUMAN, Q7RTR8 (See protein sequence)
Recommended Name: Taste receptor type 2 member 42  
Size: 314 amino acids; 36195 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: A2RRP4 Q645X0

Explore the universe of human proteins at neXtProt for TAS2R42: NX_Q7RTR8

Explore proteomics data for TAS2R42 at MOPED 

TAS2R42 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TAS2R42 Protein Expression

REFSEQ proteins: NP_852094.1  
ENSEMBL proteins: 
 ENSP00000334050  
Reactome Protein details: Q7RTR8
Human Recombinant Protein Products for TAS2R42: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

TAS2R42 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TASNR: GPCR / Unclassified : Taste receptors
TAS2R: Taste receptors / Type 2

IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R42 
Taste 2 receptors

2 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR007960 TAS2_rcpt

Graphical View of Domain Structure for InterPro Entry Q7RTR8

ProtoNet protein and cluster: Q7RTR8

UniProtKB/Swiss-Prot: T2R42_HUMAN, Q7RTR8
Similarity: Belongs to the G-protein coupled receptor T2R family


TAS2R42 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T2R42_HUMAN, Q7RTR8
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
TAS2R42 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TAS2R42 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
Taste transduction0.45
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71
G alpha (i) signalling events0.46

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/6        Reactome Pathways for TAS2R42 (see all 6)
    GPCR downstream signaling
Signal Transduction
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by GPCR
G alpha (i) signalling events


1         Kegg Pathway  (Kegg details for TAS2R42):
    Taste transduction


TAS2R42 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R42

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TAS2R42 (ENSP000003340504) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GNAT3ENSP000003813394STRING: ENSP00000381339
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0050909sensory perception of taste IEA--

TAS2R42 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS2R42 (T2R42)

Search CenterWatch for drugs/clinical trials and news about TAS2R42 / T2R42

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAS2R42 gene: 
NM_181429.1  

Unigene Cluster for TAS2R42:

Taste receptor, type 2, member 42
Hs.553716
Unigene Representative Sequence: NM_181429
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000334266(uc001qzr.1)
miRNA
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Additional mRNA sequence: BC131742.1 

1 DOTS entry:

DT.100701085 

1 AceView cDNA sequence:

NM_181429 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAS2R42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTAGCCTTAA
TAS2R42 Expression
About this image


See TAS2R42 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553716
    SABiosciences Custom PCR Arrays for TAS2R42
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TAS2R42 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tas2r1311 , 5 taste receptor, type 2, member 1311, 5 66.44(n)1
50.52(a)1
  6 (64.03 cM)5
3873561  NM_207030.11  NP_996913.11 
 1329569125 


ENSEMBL Gene Tree for TAS2R42 (if available)
TreeFam Gene Tree for TAS2R42 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TAS2R42 gene
TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
TAS2R382  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R202  
TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
18/54 SIMAP similar genes for TAS2R42 using alignment to 1 protein entry:     T2R42_HUMAN(see all similar genes):
Hosa(Biaka)-T2R55    Hosa(Adygei)-T2R55    Hosa(Japanese)-T2R55    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R7    Hosa(Japanese)-T2R14
TAS2R7    TAS2R14    Hosa(Adygei)-T2R10    Hosa(Biaka)-T2R10    Hosa(Biaka)-T2R3    Hosa(Biaka)-T2R43
Hosa(Biaka)-T2R47    Hosa(Japanese)-T2R10    Hosa(Adygei)-T2R3    Hosa(Japanese)-T2R49    TAS2R10    TAS2R3

TAS2R42 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/115 SNPs in TAS2R42 are shown (see all 115)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1858234821,2
--11338117(+) CTGGGC/TGACAG 1 -- ds50010--------
rs669206771,2
C--11338137(+) AAAAA-/AAAA  
  
/AAAAA
AAAAA
1 -- ds50011NA 2
rs669206761,2
C--11338153(+) AAAAAG/AAAAAA 1 -- ds50012Minor allele frequency- A:0.00NA 4
rs671983791,2
C--11338157(+) AAAAAA/GAAAAA 1 -- ds50010--------
rs1923972701,2
--11338199(+) TTTCCC/TGCTGT 1 -- ds50010--------
rs1832261551,2
--11338327(+) CTATCA/GTTTGC 1 -- ds50010--------
rs1861413381,2
--11338433(+) GTATCA/GACCGG 1 -- ds50010--------
rs1480264021,2
--11338437(+) CGACCA/GGCAAT 1 -- ds50010--------
rs1417427581,2
--11338455(+) TTACCA/CTCAAA 1 -- ds50010--------
rs57964291,2
C--11338515(+) AGTAG-/AAAAAAA 1 -- ds50011Minor allele frequency- AA:0.00NA 2

HapMap Linkage Disequilibrium report for TAS2R42 (11338599 - 11339543 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for TAS2R42:    About this table     
Variant IDTypeSubtypePubMed ID
dgv1374n71CNV Loss21882294
nsv8918CNV Gain18304495
nsv428272CNV Gain+Loss18775914
dgv475e1CNV Complex17122850
dgv476e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAS2R42 for disorders           About MalaCards
OMIM gene information: 613966    OMIM disorders: --


TAS2R42 for disorders           About GeneDecksing


Export disorders for TAS2R42 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAS2R42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAS2R42)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Adaptive diversification of bitter taste receptor genes in mammalian evolution. (PubMed id 12679530)1, 2, 3 Shi P.... Zhang Y.-P. (2003)
  2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
  3. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
  4. Major haplotypes of the human bitter taste receptor TA S2R41 encode functional receptors for chloramphenicol. (PubMed id 23632330)1 Thalmann S....Meyerhof W. (2013)
  5. Patients with phantogeusia show increased expression o f T2R taste receptor genes in their tongues. (PubMed id 22397221)1 Hirai R....Ikeda M. (2012)
  6. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 353164 HGNC: 18888 AceView: T2R55.1 Ensembl:ENSG00000186136 euGenes: HUgn353164
ECgene: TAS2R42 Kegg: 353164 H-InvDB: TAS2R42

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TAS2R42 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TAS2R42 gene:
Search GeneIP for patents involving TAS2R42

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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