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Aliases for TAS2R42 Gene

Aliases for TAS2R42 Gene

  • Taste 2 Receptor Member 42 2 3 5
  • Taste Receptor, Type 2, Member 42 2 3
  • Taste Receptor Type 2 Member 55 3 4
  • TAS2R55 3 4
  • T2R42 3 4
  • T2R55 3 4
  • Candidate Taste Receptor HT2R55 3
  • Taste Receptor Type 2 Member 42 3
  • T2R24 3

External Ids for TAS2R42 Gene

Previous GeneCards Identifiers for TAS2R42 Gene

  • GC00U991251
  • GC12M011231
  • GC12M011338
  • GC12M011101

Summaries for TAS2R42 Gene

GeneCards Summary for TAS2R42 Gene

TAS2R42 (Taste 2 Receptor Member 42) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot for TAS2R42 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R42 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R42 Gene

Genomics for TAS2R42 Gene

Regulatory Elements for TAS2R42 Gene

Enhancers for TAS2R42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F011578 1.1 FANTOM5 Ensembl 5.1 -391.7 -391733 0.5 HDGF TBP PKNOX1 BMI1 EBF1 RELA POLR2A EED ETV6 CREM ETV6 TAS2R42 TAS2R43 ENSG00000256237
GH12F011429 0.3 FANTOM5 2.6 -242.8 -242766 0.3 TAS2R50 TAS2R42 TAS2R43 GC12M011538 PRB1
GH12F011583 0.3 FANTOM5 1.8 -397.1 -397080 0.4 ETV6 TAS2R42 ENSG00000256237
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R42 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R42 Gene

Chromosome:
12
Start:
11,185,993 bp from pter
End:
11,186,937 bp from pter
Size:
945 bases
Orientation:
Minus strand

Genomic View for TAS2R42 Gene

Genes around TAS2R42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R42 Gene

Proteins for TAS2R42 Gene

  • Protein details for TAS2R42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTR8-T2R42_HUMAN
    Recommended name:
    Taste receptor type 2 member 42
    Protein Accession:
    Q7RTR8
    Secondary Accessions:
    • A2RRP4
    • Q645X0

    Protein attributes for TAS2R42 Gene

    Size:
    314 amino acids
    Molecular mass:
    36195 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R42 Gene

Post-translational modifications for TAS2R42 Gene

Other Protein References for TAS2R42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R42 Gene

Domains & Families for TAS2R42 Gene

Gene Families for TAS2R42 Gene

Protein Domains for TAS2R42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTR8

UniProtKB/Swiss-Prot:

T2R42_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R42: view

Function for TAS2R42 Gene

Molecular function for TAS2R42 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 NOT bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R42: view
genes like me logo Genes that share phenotypes with TAS2R42: view

Animal Models for TAS2R42 Gene

MGI Knock Outs for TAS2R42:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R42 Gene

Localization for TAS2R42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R42 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R42 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TAS2R42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 20022913
genes like me logo Genes that share ontologies with TAS2R42: view

Pathways & Interactions for TAS2R42 Gene

genes like me logo Genes that share pathways with TAS2R42: view

Pathways by source for TAS2R42 Gene

Gene Ontology (GO) - Biological Process for TAS2R42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 NOT detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R42: view

No data available for SIGNOR curated interactions for TAS2R42 Gene

Transcripts for TAS2R42 Gene

mRNA/cDNA for TAS2R42 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R42 Gene

No ASD Table

Relevant External Links for TAS2R42 Gene

GeneLoc Exon Structure for
TAS2R42
ECgene alternative splicing isoforms for
TAS2R42

Expression for TAS2R42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R42 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R42 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAS2R42 Gene:

TAS2R42

SOURCE GeneReport for Unigene cluster for TAS2R42 Gene:

Hs.553716
genes like me logo Genes that share expression patterns with TAS2R42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TAS2R42 Gene

Orthologs for TAS2R42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R42 34
  • 98.62 (n)
dog
(Canis familiaris)
Mammalia TAS2R42 34 35
  • 78.24 (n)
mouse
(Mus musculus)
Mammalia Tas2r131 34 16 35
  • 66.44 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r145 34
  • 65.87 (n)
cow
(Bos Taurus)
Mammalia TAS2R42 35
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R24 35
  • 35 (a)
ManyToMany
T2R25 35
  • 35 (a)
ManyToMany
T2R23 35
  • 33 (a)
ManyToMany
Species where no ortholog for TAS2R42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R42 Gene

ENSEMBL:
Gene Tree for TAS2R42 (if available)
TreeFam:
Gene Tree for TAS2R42 (if available)

Paralogs for TAS2R42 Gene

genes like me logo Genes that share paralogs with TAS2R42: view

Variants for TAS2R42 Gene

Sequence variations from dbSNP and Humsavar for TAS2R42 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111961186 -- 11,185,926(+) AAAAA(-/CA)GTGGA downstream-variant-500B
rs114561198 -- 11,188,667(+) TGGAT(A/G)CATGT upstream-variant-2KB
rs137988425 -- 11,186,751(+) AAACA(G/T)TATCA reference, missense
rs138717830 -- 11,188,631(+) TGCAA(-/AATG)TGACA upstream-variant-2KB
rs139102816 -- 11,186,772(+) TCCAA(C/T)TGTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R42 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
nsv1038277 CNV loss 25217958
nsv1050050 CNV loss 25217958
nsv428272 CNV gain+loss 18775914
nsv8918 CNV gain 18304495

Variation tolerance for TAS2R42 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R42 Gene

Human Gene Mutation Database (HGMD)
TAS2R42
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R42 Gene

Disorders for TAS2R42 Gene

Relevant External Links for TAS2R42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R42

No disorders were found for TAS2R42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R42 Gene

Publications for TAS2R42 Gene

  1. Adaptive diversification of bitter taste receptor genes in mammalian evolution. (PMID: 12679530) Shi P. … Zhang Y.-P. (Mol. Biol. Evol. 2003) 2 3 4 64
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  3. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  4. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. (PMID: 23632330) Thalmann S. … Meyerhof W. (Biochem. Biophys. Res. Commun. 2013) 3 64
  5. Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues. (PMID: 22397221) Hirai R. … Ikeda M. (Ann. Otol. Rhinol. Laryngol. 2012) 3 64

Products for TAS2R42 Gene

Sources for TAS2R42 Gene

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