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Aliases for TAS2R41 Gene

Aliases for TAS2R41 Gene

  • Taste Receptor, Type 2, Member 41 2 3
  • T2R59 3 4 6
  • Taste Receptor Type 2 Member 59 3 4
  • T2R41 3 4
  • Taste Receptor Type 2 Member 41 3

External Ids for TAS2R41 Gene

Summaries for TAS2R41 Gene

GeneCards Summary for TAS2R41 Gene

TAS2R41 (Taste Receptor, Type 2, Member 41) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R41 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R41 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R41 Gene

Genomics for TAS2R41 Gene

Genomic Location for TAS2R41 Gene

Start:
143,477,873 bp from pter
End:
143,478,796 bp from pter
Size:
924 bases
Orientation:
Plus strand

Genomic View for TAS2R41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R41 Gene

Regulatory Elements for TAS2R41 Gene

Proteins for TAS2R41 Gene

  • Protein details for TAS2R41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59536-T2R41_HUMAN
    Recommended name:
    Taste receptor type 2 member 41
    Protein Accession:
    P59536
    Secondary Accessions:
    • P59550
    • Q495I2
    • Q50KJ5
    • Q50KJ6
    • Q50KJ7
    • Q645W7

    Protein attributes for TAS2R41 Gene

    Size:
    307 amino acids
    Molecular mass:
    35896 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R41 Gene

Proteomics data for TAS2R41 Gene at MOPED

Post-translational modifications for TAS2R41 Gene

Other Protein References for TAS2R41 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R41 Gene

Domains for TAS2R41 Gene

Gene Families for TAS2R41 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R41 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T2R41_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • P59536
genes like me logo Genes that share domains with TAS2R41: view

Function for TAS2R41 Gene

Molecular function for TAS2R41 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0033038 NOT bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R41: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R41 Gene

Localization for TAS2R41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R41 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R41 Gene COMPARTMENTS Subcellular localization image for TAS2R41 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 20022913
genes like me logo Genes that share ontologies with TAS2R41: view

Pathways for TAS2R41 Gene

genes like me logo Genes that share pathways with TAS2R41: view

Pathways by source for TAS2R41 Gene

1 KEGG pathway for TAS2R41 Gene

Interacting Proteins for TAS2R41 Gene

Gene Ontology (GO) - Biological Process for TAS2R41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 NOT detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R41: view

Transcripts for TAS2R41 Gene

mRNA/cDNA for TAS2R41 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R41 Gene

No ASD Table

Relevant External Links for TAS2R41 Gene

GeneLoc Exon Structure for
TAS2R41
ECgene alternative splicing isoforms for
TAS2R41

Expression for TAS2R41 Gene

mRNA expression in normal human tissues for TAS2R41 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAS2R41 Gene

SOURCE GeneReport for Unigene cluster for TAS2R41 Gene Hs.650648

mRNA Expression by UniProt/SwissProt for TAS2R41 Gene

P59536-T2R41_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R41: view

Orthologs for TAS2R41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R41 36
  • 99.13 (n)
  • 98.37 (a)
TAS2R41 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 36 (a)
ManyToMany
TAS2R41 36
  • 76.64 (n)
  • 67.33 (a)
dog
(Canis familiaris)
Mammalia TAS2R41 36
  • 76.35 (n)
  • 69.64 (a)
TAS2R41 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r126 36
  • 76.97 (n)
  • 70.14 (a)
Tas2r126 16
Tas2r126 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia T2R41 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r126 36
  • 76.5 (n)
  • 71.87 (a)
chicken
(Gallus gallus)
Aves TAS2R7 37
  • 24 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia t2r11 36
  • 48.58 (n)
  • 36.82 (a)
Species with no ortholog for TAS2R41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R41 Gene

ENSEMBL:
Gene Tree for TAS2R41 (if available)
TreeFam:
Gene Tree for TAS2R41 (if available)

Paralogs for TAS2R41 Gene

genes like me logo Genes that share paralogs with TAS2R41: view

Variants for TAS2R41 Gene

Sequence variations from dbSNP and Humsavar for TAS2R41 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_060211 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R41 Gene

Variant ID Type Subtype PubMed ID
dgv2147e1 CNV Complex 17122850
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850

Relevant External Links for TAS2R41 Gene

HapMap Linkage Disequilibrium report
TAS2R41

Disorders for TAS2R41 Gene

No disorders were found for TAS2R41 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R41 Gene

Publications for TAS2R41 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4
  2. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  3. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PMID: 12584440) Conte C. … Andres-Barquin P.J. (Cytogenet. Genome Res. 2002) 3 4

Products for TAS2R41 Gene

Sources for TAS2R41 Gene

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