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Aliases for TAS2R41 Gene

Aliases for TAS2R41 Gene

  • Taste 2 Receptor Member 41 2 3 5
  • Taste Receptor, Type 2, Member 41 2 3
  • Taste Receptor Type 2 Member 59 3 4
  • T2R41 3 4
  • T2R59 3 4
  • Taste Receptor Type 2 Member 41 3

External Ids for TAS2R41 Gene

Previous GeneCards Identifiers for TAS2R41 Gene

  • GC00U991250
  • GC07P142569
  • GC07P142645
  • GC07P142691
  • GC07P142886
  • GC07P143174
  • GC07P137512

Summaries for TAS2R41 Gene

GeneCards Summary for TAS2R41 Gene

TAS2R41 (Taste 2 Receptor Member 41) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R60.

UniProtKB/Swiss-Prot for TAS2R41 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R41 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R41 Gene

Genomics for TAS2R41 Gene

Regulatory Elements for TAS2R41 Gene

Enhancers for TAS2R41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G143415 1 Ensembl ENCODE 10.8 -61.6 -61646 1.9 CTCF ARNT CEBPG RAD21 IRF9 SMC3 ZNF654 TRIM22 CEBPB REST GSTK1 ZYX LOC100507507 TAS2R41 FAM131B EPHA1 TAS2R62P
GH07G143498 0.9 Ensembl ENCODE 11.7 +21.8 21785 2.3 ZNF316 GATA3 JUND GATA2 JUN SIN3A FOS NR2F2 TAS2R41 FAM131B EPHA1-AS1 EPHA1 LOC105375547 OR10AC1
GH07G143519 0.8 Ensembl ENCODE 11.8 +41.9 41870 0.8 ZFHX2 EGR1 SAP30 SIN3A TAS2R41 FAM131B ARHGEF35 CTAGE6 OR10AC1 GC07M143535
GH07G143351 0.8 FANTOM5 dbSUPER 7.7 -126.7 -126661 0.1 FOSL1 SMARCE1 RAD51 JUND ZNF512 USF2 ZYX LOC100507507 HINT1P1 CLCN1 EPHA1-AS1 EPHA1 TAS2R41 FAM131B OR6V1 OR9A2
GH07G143413 1.1 FANTOM5 Ensembl 5.2 -64.0 -63972 1.8 BCOR YBX3 ATF1 ARNT ZNF384 CEBPG ZBTB40 ZNF644 ZNF766 SMARCE1 EPHA1-AS1 TAS2R41 EPHA1 OR6V1 TAS2R62P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R41 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R41 Gene

Chromosome:
7
Start:
143,477,873 bp from pter
End:
143,478,796 bp from pter
Size:
924 bases
Orientation:
Plus strand

Genomic View for TAS2R41 Gene

Genes around TAS2R41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R41 Gene

Proteins for TAS2R41 Gene

  • Protein details for TAS2R41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59536-T2R41_HUMAN
    Recommended name:
    Taste receptor type 2 member 41
    Protein Accession:
    P59536
    Secondary Accessions:
    • P59550
    • Q495I2
    • Q50KJ5
    • Q50KJ6
    • Q50KJ7
    • Q645W7

    Protein attributes for TAS2R41 Gene

    Size:
    307 amino acids
    Molecular mass:
    35896 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R41 Gene

Post-translational modifications for TAS2R41 Gene

  • Glycosylation at Asn167
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R41 Gene

Domains & Families for TAS2R41 Gene

Gene Families for TAS2R41 Gene

Protein Domains for TAS2R41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59536

UniProtKB/Swiss-Prot:

T2R41_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R41: view

Function for TAS2R41 Gene

Molecular function for TAS2R41 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 NOT bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R41: view
genes like me logo Genes that share phenotypes with TAS2R41: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R41 Gene

Localization for TAS2R41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R41 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R41 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 20022913
genes like me logo Genes that share ontologies with TAS2R41: view

Pathways & Interactions for TAS2R41 Gene

genes like me logo Genes that share pathways with TAS2R41: view

Pathways by source for TAS2R41 Gene

Gene Ontology (GO) - Biological Process for TAS2R41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 NOT detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R41: view

No data available for SIGNOR curated interactions for TAS2R41 Gene

Drugs & Compounds for TAS2R41 Gene

No Compound Related Data Available

Transcripts for TAS2R41 Gene

mRNA/cDNA for TAS2R41 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R41 Gene

No ASD Table

Relevant External Links for TAS2R41 Gene

GeneLoc Exon Structure for
TAS2R41
ECgene alternative splicing isoforms for
TAS2R41

Expression for TAS2R41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R41 Gene

Protein differential expression in normal tissues from HIPED for TAS2R41 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R41 Gene



Protein tissue co-expression partners for TAS2R41 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R41 Gene:

TAS2R41

SOURCE GeneReport for Unigene cluster for TAS2R41 Gene:

Hs.650648

mRNA Expression by UniProt/SwissProt for TAS2R41 Gene:

P59536-T2R41_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R41: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R41 Gene

Orthologs for TAS2R41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R41 34 35
  • 99.13 (n)
mouse
(Mus musculus)
Mammalia Tas2r126 34 16 35
  • 76.97 (n)
cow
(Bos Taurus)
Mammalia TAS2R41 34
  • 76.64 (n)
-- 35
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tas2r126 34
  • 76.5 (n)
dog
(Canis familiaris)
Mammalia TAS2R41 34 35
  • 76.35 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R41 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS2R7 35
  • 24 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia t2r11 34
  • 48.58 (n)
Species where no ortholog for TAS2R41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R41 Gene

ENSEMBL:
Gene Tree for TAS2R41 (if available)
TreeFam:
Gene Tree for TAS2R41 (if available)

Paralogs for TAS2R41 Gene

genes like me logo Genes that share paralogs with TAS2R41: view

Variants for TAS2R41 Gene

Sequence variations from dbSNP and Humsavar for TAS2R41 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001055206 -- 143,477,168(+) AGAGG(A/C)CTCTA intron-variant, upstream-variant-2KB
rs1001105841 -- 143,477,481(+) CTATA(C/T)TTGTC intron-variant, upstream-variant-2KB
rs1001671491 -- 143,477,434(+) GTACT(A/G)AGACA intron-variant, upstream-variant-2KB
rs1001805417 -- 143,477,784(+) ACTCC(C/T)AGGAA intron-variant, upstream-variant-2KB
rs1002137754 -- 143,475,910(+) AGGAA(C/T)TTATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R41 Gene

Variant ID Type Subtype PubMed ID
esv2759570 CNV gain+loss 17122850
esv3891218 CNV loss 25118596
nsv428188 CNV gain+loss 18775914
nsv608682 CNV gain 21841781

Variation tolerance for TAS2R41 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 79.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R41 Gene

Disorders for TAS2R41 Gene

Relevant External Links for TAS2R41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R41

No disorders were found for TAS2R41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R41 Gene

Publications for TAS2R41 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4 64
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  3. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PMID: 15744053) Go Y. … Takahata N. (Genetics 2005) 3 4 64
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4 64

Products for TAS2R41 Gene

Sources for TAS2R41 Gene

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