Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAS2R40 Gene

Aliases for TAS2R40 Gene

  • Taste 2 Receptor Member 40 2 3 5
  • Taste Receptor, Type 2, Member 40 2 3
  • Taste Receptor Type 2 Member 58 3 4
  • G-Protein Coupled Receptor 60 3 4
  • GPR60 3 4
  • T2R40 3 4
  • T2R58 3 4
  • Taste Receptor Type 2 Member 40 3
  • G Protein-Coupled Receptor 60 2

External Ids for TAS2R40 Gene

Previous HGNC Symbols for TAS2R40 Gene

  • GPR60

Previous GeneCards Identifiers for TAS2R40 Gene

  • GC00U991249
  • GC07U900008
  • GC07P142313
  • GC07P142390
  • GC07P142436
  • GC07P142629
  • GC07P142919
  • GC07P137258

Summaries for TAS2R40 Gene

GeneCards Summary for TAS2R40 Gene

TAS2R40 (Taste 2 Receptor Member 40) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R39.

UniProtKB/Swiss-Prot for TAS2R40 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R40 Gene

Genomics for TAS2R40 Gene

Regulatory Elements for TAS2R40 Gene

Enhancers for TAS2R40 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143003 0.9 Ensembl ENCODE 11.7 -218.6 -218637 0.8 CTCF ZNF654 TRIM22 REST RAD21 YY1 IKZF1 ZNF512 SMC3 ZNF143 TAS2R40 OR9A2 OR9P1P OR6V1 KEL
GH07F143009 0.8 ENCODE 11.7 -213.9 -213939 0.2 CTCF ATF1 CBX3 MAX RAD21 ZNF143 SMC3 ZSCAN29 CREM ZNF654 TAS2R40 OR9P1P OR6V1 OR9A2 KEL
GH07F143008 0.7 Ensembl 11.7 -213.7 -213737 0.2 CTCF ATF1 CBX3 MAX RAD21 ZNF143 SMC3 CREM ZNF654 NFIA TAS2R40 OR9P1P OR6V1 OR9A2 KEL
GH07F143244 1.1 FANTOM5 Ensembl ENCODE 3.3 +23.1 23115 3.7 MCM7 PKNOX1 MCM3 ZNF266 KDM1A MYC FAM131B TMEM139 LOC105375545 CASP2 RN7SL535P LOC100507507 ZYX OR9A2 TAS2R39 TRPV6
GH07F143378 1.8 FANTOM5 Ensembl ENCODE 1.2 +164.2 164158 15.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZYX EPHA1-AS1 EPHA1 CLCN1 HINT1P1 OR2A1 FAM131B LOC100507507 TAS2R60 ARHGEF35
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R40 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R40 Gene

Chromosome:
7
Start:
143,222,037 bp from pter
End:
143,223,079 bp from pter
Size:
1,043 bases
Orientation:
Plus strand

Genomic View for TAS2R40 Gene

Genes around TAS2R40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R40 Gene

Proteins for TAS2R40 Gene

  • Protein details for TAS2R40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59535-T2R40_HUMAN
    Recommended name:
    Taste receptor type 2 member 40
    Protein Accession:
    P59535
    Secondary Accessions:
    • A4D2I2
    • Q645W6

    Protein attributes for TAS2R40 Gene

    Size:
    323 amino acids
    Molecular mass:
    36812 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R40 Gene

Post-translational modifications for TAS2R40 Gene

  • Glycosylation at Asn 170 and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R40 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R40 Gene

Domains & Families for TAS2R40 Gene

Gene Families for TAS2R40 Gene

Protein Domains for TAS2R40 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59535

UniProtKB/Swiss-Prot:

T2R40_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R40: view

Function for TAS2R40 Gene

Molecular function for TAS2R40 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R40: view
genes like me logo Genes that share phenotypes with TAS2R40: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R40 Gene

Localization for TAS2R40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R40 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R40 gene
Compartment Confidence
plasma membrane 5
lysosome 1

Gene Ontology (GO) - Cellular Components for TAS2R40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R40: view

Pathways & Interactions for TAS2R40 Gene

genes like me logo Genes that share pathways with TAS2R40: view

Pathways by source for TAS2R40 Gene

Gene Ontology (GO) - Biological Process for TAS2R40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R40: view

No data available for SIGNOR curated interactions for TAS2R40 Gene

Drugs & Compounds for TAS2R40 Gene

(5) Drugs for TAS2R40 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dapsone Approved, Investigational Pharma 68
Diphenidol Approved, Withdrawn Pharma 1
Quinine Approved Pharma Pore Blocker 45
Chlorpheniramine Pharma 69
calcium Nutra 0

(6) Additional Compounds for TAS2R40 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adhumulone
28374-89-2
Cohumulone
  • 3,4,5-Trihydroxy-2,4-bis(3-methyl-2-butenyl)-6-(2-methyl-1-oxopropyl)-2,5-cyclohexadien-1-one, 9CI
  • 5-(alpha,beta-Dibromophenethyl)-5-methylhydantoin
511-25-1
Colupulone
  • Co-lupulone
468-27-9
Humulon,Humulone
26472-41-3
Isoxanthohumol
  • 4',7-Dihydroxy-5-methoxy-8-prenylflavanone
  • 5-Methyl-8-prenylnaringenin
  • 7,4'-Dihydroxy-5-methoxy-8-prenylflavanone
  • Isoxanthohumol
70872-29-6
genes like me logo Genes that share compounds with TAS2R40: view

Transcripts for TAS2R40 Gene

mRNA/cDNA for TAS2R40 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R40 Gene

Taste receptor, type 2, member 40:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R40 Gene

No ASD Table

Relevant External Links for TAS2R40 Gene

GeneLoc Exon Structure for
TAS2R40
ECgene alternative splicing isoforms for
TAS2R40

Expression for TAS2R40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R40 Gene

mRNA expression in normal human tissues for TAS2R40 Gene

Protein differential expression in normal tissues from HIPED for TAS2R40 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R40 Gene



Protein tissue co-expression partners for TAS2R40 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R40 Gene:

TAS2R40

SOURCE GeneReport for Unigene cluster for TAS2R40 Gene:

Hs.352241

mRNA Expression by UniProt/SwissProt for TAS2R40 Gene:

P59535-T2R40_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R40: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAS2R40 Gene

Orthologs for TAS2R40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R40 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia TAS2R40 34 35
  • 84.53 (n)
mouse
(Mus musculus)
Mammalia Tas2r144 34 16 35
  • 78.51 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r144 34
  • 77.67 (n)
cow
(Bos Taurus)
Mammalia TAS2R40 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia T2R40 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749182 34
  • 54.5 (n)
TAS2R7 35
  • 25 (a)
OneToMany
Species where no ortholog for TAS2R40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R40 Gene

ENSEMBL:
Gene Tree for TAS2R40 (if available)
TreeFam:
Gene Tree for TAS2R40 (if available)

Paralogs for TAS2R40 Gene

Variants for TAS2R40 Gene

Sequence variations from dbSNP and Humsavar for TAS2R40 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10225801 -- 143,221,510(+) TATTC(A/G)AGGAC upstream-variant-2KB
rs10260248 -- 143,222,638(+) CTTCT(A/C)TGAGA reference, missense
rs113103334 -- 143,221,315(+) TTTCC(A/G)AACTT upstream-variant-2KB
rs114996295 -- 143,223,153(+) CTCTG(A/T)CACTT downstream-variant-500B
rs115429355 -- 143,220,437(+) TGTGA(A/G)GGATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R40 Gene

Variant ID Type Subtype PubMed ID
dgv11660n54 CNV loss 21841781
nsv508488 CNV deletion 20534489
nsv831169 CNV loss 17160897

Variation tolerance for TAS2R40 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R40 Gene

Disorders for TAS2R40 Gene

Relevant External Links for TAS2R40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R40

No disorders were found for TAS2R40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R40 Gene

Publications for TAS2R40 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4 64
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64

Products for TAS2R40 Gene

Sources for TAS2R40 Gene

Content
Loading form....