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Aliases for TAS2R40 Gene

Aliases for TAS2R40 Gene

  • Taste 2 Receptor Member 40 2 3 5
  • Taste Receptor, Type 2, Member 40 2 3
  • Taste Receptor Type 2 Member 58 3 4
  • G Protein-Coupled Receptor 60 2 3
  • G-Protein Coupled Receptor 60 3 4
  • GPR60 3 4
  • T2R40 3 4
  • T2R58 3 4

External Ids for TAS2R40 Gene

Previous HGNC Symbols for TAS2R40 Gene

  • GPR60

Previous GeneCards Identifiers for TAS2R40 Gene

  • GC00U991249
  • GC07U900008
  • GC07P142313
  • GC07P142390
  • GC07P142436
  • GC07P142629
  • GC07P142919
  • GC07P137258

Summaries for TAS2R40 Gene

GeneCards Summary for TAS2R40 Gene

TAS2R40 (Taste 2 Receptor Member 40) is a Protein Coding gene. Among its related pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R40 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R40 Gene

Genomics for TAS2R40 Gene

Regulatory Elements for TAS2R40 Gene

Enhancers for TAS2R40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R40 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R40 Gene

143,222,037 bp from pter
143,223,079 bp from pter
1,043 bases
Plus strand

Genomic View for TAS2R40 Gene

Genes around TAS2R40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R40 Gene

Proteins for TAS2R40 Gene

  • Protein details for TAS2R40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Taste receptor type 2 member 40
    Protein Accession:
    Secondary Accessions:
    • A4D2I2
    • Q645W6

    Protein attributes for TAS2R40 Gene

    323 amino acids
    Molecular mass:
    36812 Da
    Quaternary structure:
    No Data Available
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R40 Gene

Proteomics data for TAS2R40 Gene at MOPED

Post-translational modifications for TAS2R40 Gene

  • Glycosylation at Asn 170 and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R40 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R40 Gene

Domains & Families for TAS2R40 Gene

Gene Families for TAS2R40 Gene

Protein Domains for TAS2R40 Gene


Suggested Antigen Peptide Sequences for TAS2R40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor T2R family.
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R40: view

Function for TAS2R40 Gene

Molecular function for TAS2R40 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
genes like me logo Genes that share phenotypes with TAS2R40: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R40 Gene

Localization for TAS2R40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R40 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TAS2R40 Gene COMPARTMENTS Subcellular localization image for TAS2R40 gene
Compartment Confidence
plasma membrane 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TAS2R40 Gene

Pathways & Interactions for TAS2R40 Gene

genes like me logo Genes that share pathways with TAS2R40: view

Pathways by source for TAS2R40 Gene

Interacting Proteins for TAS2R40 Gene

Gene Ontology (GO) - Biological Process for TAS2R40 Gene


No data available for SIGNOR curated interactions for TAS2R40 Gene

Drugs & Compounds for TAS2R40 Gene

(5) Drugs for TAS2R40 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorpheniramine Approved Pharma 66
Dapsone Approved, Investigational Pharma 63
Diphenidol Approved, Withdrawn Pharma 1
Quinine Approved Pharma Pore Blocker 42
calcium Nutra 0

(6) Additional Compounds for TAS2R40 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 3,4,5-Trihydroxy-2,4-bis(3-methyl-2-butenyl)-6-(2-methyl-1-oxopropyl)-2,5-cyclohexadien-1-one, 9CI
  • 5-(alpha,beta-Dibromophenethyl)-5-methylhydantoin
  • Co-lupulone
  • 4',7-Dihydroxy-5-methoxy-8-prenylflavanone
  • 5-Methyl-8-prenylnaringenin
  • 7,4'-Dihydroxy-5-methoxy-8-prenylflavanone
  • Isoxanthohumol
genes like me logo Genes that share compounds with TAS2R40: view

Transcripts for TAS2R40 Gene

mRNA/cDNA for TAS2R40 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R40 Gene

Taste receptor, type 2, member 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R40 Gene

No ASD Table

Relevant External Links for TAS2R40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAS2R40 Gene

mRNA expression in normal human tissues for TAS2R40 Gene

mRNA expression in normal human tissues for TAS2R40 Gene

Protein differential expression in normal tissues from HIPED for TAS2R40 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R40 Gene

SOURCE GeneReport for Unigene cluster for TAS2R40 Gene Hs.352241

mRNA Expression by UniProt/SwissProt for TAS2R40 Gene

Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R40: view

Protein tissue co-expression partners for TAS2R40 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAS2R40 Gene

Orthologs for TAS2R40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R40 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TAS2R40 35
  • 84.53 (n)
  • 76.14 (a)
TAS2R40 36
  • 76 (a)
(Mus musculus)
Mammalia Tas2r144 35
  • 78.51 (n)
  • 66.35 (a)
Tas2r144 16
Tas2r144 36
  • 66 (a)
(Pan troglodytes)
Mammalia TAS2R40 35
  • 99.69 (n)
  • 99.38 (a)
TAS2R40 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tas2r144 35
  • 77.67 (n)
  • 65.09 (a)
(Bos Taurus)
Mammalia TAS2R40 36
  • 71 (a)
(Monodelphis domestica)
Mammalia T2R40 36
  • 61 (a)
(Gallus gallus)
Aves LOC101749182 35
  • 54.5 (n)
  • 39.86 (a)
TAS2R7 36
  • 25 (a)
Species with no ortholog for TAS2R40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R40 Gene

Gene Tree for TAS2R40 (if available)
Gene Tree for TAS2R40 (if available)

Paralogs for TAS2R40 Gene

genes like me logo Genes that share paralogs with TAS2R40: view

Variants for TAS2R40 Gene

Sequence variations from dbSNP and Humsavar for TAS2R40 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17164164 - 143,222,145(+) CTTTG(C/G)TGGTC reference, missense
rs10260248 - 143,222,638(+) CTTCT(A/C)TGAGA reference, missense
rs10225801 -- 143,221,510(+) TATTC(A/G)AGGAC upstream-variant-2KB
rs76255203 -- 143,223,005(+) AAGCG(A/G)TTTCA reference, synonymous-codon
rs138574611 -- 143,223,331(+) GAGAG(A/G)GTGGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TAS2R40 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV Loss 17160897
nsv508488 CNV Loss 20534489

Variation tolerance for TAS2R40 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAS2R40 Gene

Disorders for TAS2R40 Gene

Relevant External Links for TAS2R40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TAS2R40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R40 Gene

Publications for TAS2R40 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4 67
  2. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  3. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  4. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3
  5. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PMID: 15744053) Go Y. … Takahata N. (Genetics 2005) 3

Products for TAS2R40 Gene

Sources for TAS2R40 Gene