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Aliases for TAS2R40 Gene

Aliases for TAS2R40 Gene

  • Taste Receptor, Type 2, Member 40 2 3
  • T2R40 3 4 6
  • Taste Receptor Type 2 Member 58 3 4
  • G Protein-Coupled Receptor 60 2 3
  • G-Protein Coupled Receptor 60 3 4
  • GPR60 3 4
  • T2R58 3 4
  • Taste Receptor Type 2 Member 40 3

External Ids for TAS2R40 Gene

Previous HGNC Symbols for TAS2R40 Gene

  • GPR60

Previous GeneCards Identifiers for TAS2R40 Gene

  • GC00U991249
  • GC07U900008
  • GC07P142313
  • GC07P142390
  • GC07P142436
  • GC07P142629
  • GC07P142919
  • GC07P137258

Summaries for TAS2R40 Gene

GeneCards Summary for TAS2R40 Gene

TAS2R40 (Taste Receptor, Type 2, Member 40) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R40 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

Gene Wiki entry for TAS2R40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R40 Gene

Genomics for TAS2R40 Gene

Regulatory Elements for TAS2R40 Gene

Genomic Location for TAS2R40 Gene

Start:
143,222,037 bp from pter
End:
143,223,079 bp from pter
Size:
1,043 bases
Orientation:
Plus strand

Genomic View for TAS2R40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R40 Gene

Proteins for TAS2R40 Gene

  • Protein details for TAS2R40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59535-T2R40_HUMAN
    Recommended name:
    Taste receptor type 2 member 40
    Protein Accession:
    P59535
    Secondary Accessions:
    • A4D2I2
    • Q645W6

    Protein attributes for TAS2R40 Gene

    Size:
    323 amino acids
    Molecular mass:
    36812 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell

neXtProt entry for TAS2R40 Gene

Proteomics data for TAS2R40 Gene at MOPED

Post-translational modifications for TAS2R40 Gene

  • Glycosylation at Asn170 and Asn179
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R40 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R40 Gene

Domains for TAS2R40 Gene

Gene Families for TAS2R40 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R40 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59535

UniProtKB/Swiss-Prot:

T2R40_HUMAN :
  • P59535
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R40: view

Function for TAS2R40 Gene

Molecular function for TAS2R40 Gene

UniProtKB/Swiss-Prot Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

Gene Ontology (GO) - Molecular Function for TAS2R40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R40: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R40 Gene

Localization for TAS2R40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R40 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R40 Gene COMPARTMENTS Subcellular localization image for TAS2R40 gene
Compartment Confidence
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for TAS2R40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R40: view

Pathways for TAS2R40 Gene

genes like me logo Genes that share pathways with TAS2R40: view

Pathways by source for TAS2R40 Gene

Interacting Proteins for TAS2R40 Gene

Gene Ontology (GO) - Biological Process for TAS2R40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R40: view

Compounds for TAS2R40 Gene

(1) HMDB Compounds for TAS2R40 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(10) BitterDB Compounds for TAS2R40 Gene

Compound Smiles Cas Number
Adhumulone CCC(C)C(=O)C1=C(O)C(O)(CC=C(C)C)C(=O)C(CC=C(C)C)C1=O
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
Cohumulone CC(C)C(=O)C1=C(O)C(=C(O)C(O)(CC=C(C)C)C1=O)CC=C(C)C
Colupulone CC(C)C(=O)C1=C(O)C(=C(O)C(CC=C(C)C)(CC=C(C)C)C1=O)CC=C(C)C
dapsone Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
Humulon,Humulone CC(C)CC(=O)C1=C(O)C(=C(O)[C@@](O)(CC=C(C)C)C1=O)CC=C(C)C 26472-41-3
Isoxanthohumol COc1cc(O)c(CC=C(C)C)c2OC(CC(=O)c12)c3ccc(O)cc3
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
Xanthohumol COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)C=Cc2ccc(O)cc2
genes like me logo Genes that share compounds with TAS2R40: view

Transcripts for TAS2R40 Gene

mRNA/cDNA for TAS2R40 Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R40 Gene

Taste receptor, type 2, member 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R40 Gene

No ASD Table

Relevant External Links for TAS2R40 Gene

GeneLoc Exon Structure for
TAS2R40
ECgene alternative splicing isoforms for
TAS2R40

Expression for TAS2R40 Gene

mRNA expression in normal human tissues for TAS2R40 Gene

mRNA expression in normal human tissues for TAS2R40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAS2R40 Gene

SOURCE GeneReport for Unigene cluster for TAS2R40 Gene Hs.352241

mRNA Expression by UniProt/SwissProt for TAS2R40 Gene

P59535-T2R40_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAS2R40 Gene

Orthologs for TAS2R40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R40 35
  • 99.69 (n)
  • 99.38 (a)
TAS2R40 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R40 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R40 35
  • 84.53 (n)
  • 76.14 (a)
TAS2R40 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r144 35
  • 78.51 (n)
  • 66.35 (a)
Tas2r144 16
Tas2r144 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia T2R40 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r144 35
  • 77.67 (n)
  • 65.09 (a)
chicken
(Gallus gallus)
Aves LOC101749182 35
  • 54.5 (n)
  • 39.86 (a)
TAS2R7 36
  • 25 (a)
OneToMany
Species with no ortholog for TAS2R40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R40 Gene

ENSEMBL:
Gene Tree for TAS2R40 (if available)
TreeFam:
Gene Tree for TAS2R40 (if available)

Paralogs for TAS2R40 Gene

genes like me logo Genes that share paralogs with TAS2R40: view

Variants for TAS2R40 Gene

Sequence variations from dbSNP and Humsavar for TAS2R40 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10225801 -- 143,221,510(+) TATTC(A/G)AGGAC upstream-variant-2KB
rs10260248 - 143,222,638(+) CTTCT(A/C)TGAGA missense, reference
rs17164164 - 143,222,145(+) CTTTG(C/G)TGGTC missense, reference
rs76255203 -- 143,223,005(+) AAGCG(A/G)TTTCA synonymous-codon, reference
rs113103334 -- 143,221,315(+) TTTCC(A/G)AACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R40 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV Loss 17160897
nsv508488 CNV Loss 20534489

Relevant External Links for TAS2R40 Gene

HapMap Linkage Disequilibrium report
TAS2R40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R40 Gene

Disorders for TAS2R40 Gene

No disorders were found for TAS2R40 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R40 Gene

Publications for TAS2R40 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4
  2. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  3. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for TAS2R40 Gene

Sources for TAS2R40 Gene

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