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Aliases for TAS2R4 Gene

Aliases for TAS2R4 Gene

  • Taste 2 Receptor Member 4 2 3 5
  • Taste Receptor, Type 2, Member 4 2 3
  • T2R4 3 4
  • Candidate Taste Receptor T2R4 3

External Ids for TAS2R4 Gene

Previous GeneCards Identifiers for TAS2R4 Gene

  • GC07P139749
  • GC07P140808
  • GC07P140885
  • GC07P140931
  • GC07P141124
  • GC07P141479
  • GC07P135774
  • GC07P142610
  • GC07P142904

Summaries for TAS2R4 Gene

Entrez Gene Summary for TAS2R4 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R4 Gene

TAS2R4 (Taste 2 Receptor Member 4) is a Protein Coding gene. Among its related pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R4 Gene

  • Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Gene Wiki entry for TAS2R4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R4 Gene

Genomics for TAS2R4 Gene

Regulatory Elements for TAS2R4 Gene

Enhancers for TAS2R4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R4 Gene

Chromosome:
7
Start:
141,778,442 bp from pter
End:
141,780,819 bp from pter
Size:
2,378 bases
Orientation:
Plus strand

Genomic View for TAS2R4 Gene

Genes around TAS2R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R4 Gene

Proteins for TAS2R4 Gene

  • Protein details for TAS2R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW5-TA2R4_HUMAN
    Recommended name:
    Taste receptor type 2 member 4
    Protein Accession:
    Q9NYW5
    Secondary Accessions:
    • Q645W5
    • Q75MV8

    Protein attributes for TAS2R4 Gene

    Size:
    299 amino acids
    Molecular mass:
    33841 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R4 Gene

Proteomics data for TAS2R4 Gene at MOPED

Post-translational modifications for TAS2R4 Gene

  • Glycosylation at Asn 164, Asn 165, and Asn 169

Other Protein References for TAS2R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R4 Gene

Domains & Families for TAS2R4 Gene

Gene Families for TAS2R4 Gene

Protein Domains for TAS2R4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW5

UniProtKB/Swiss-Prot:

TA2R4_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R4: view

Function for TAS2R4 Gene

Molecular function for TAS2R4 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.
genes like me logo Genes that share phenotypes with TAS2R4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R4 Gene

Localization for TAS2R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R4 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R4 Gene COMPARTMENTS Subcellular localization image for TAS2R4 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R4 Gene

Pathways & Interactions for TAS2R4 Gene

genes like me logo Genes that share pathways with TAS2R4: view

Pathways by source for TAS2R4 Gene

Interacting Proteins for TAS2R4 Gene

Gene Ontology (GO) - Biological Process for TAS2R4 Gene

None

No data available for SIGNOR curated interactions for TAS2R4 Gene

Drugs & Compounds for TAS2R4 Gene

(10) Drugs for TAS2R4 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 155
Chlorpheniramine Approved Pharma 66
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 105
Dapsone Approved, Investigational Pharma 63
Diphenidol Approved, Withdrawn Pharma 1

(6) Additional Compounds for TAS2R4 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amarogentin
21018-84-8
Arborescin
Artemorin
Campher
denatonium benzoate
3734-33-6
genes like me logo Genes that share compounds with TAS2R4: view

Transcripts for TAS2R4 Gene

mRNA/cDNA for TAS2R4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R4 Gene

Taste receptor, type 2, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R4 Gene

No ASD Table

Relevant External Links for TAS2R4 Gene

GeneLoc Exon Structure for
TAS2R4
ECgene alternative splicing isoforms for
TAS2R4

Expression for TAS2R4 Gene

mRNA expression in normal human tissues for TAS2R4 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4) and Brain - Cerebellum (x4.2).

SOURCE GeneReport for Unigene cluster for TAS2R4 Gene Hs.735690

mRNA Expression by UniProt/SwissProt for TAS2R4 Gene

Q9NYW5-TA2R4_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.
genes like me logo Genes that share expression patterns with TAS2R4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R4 Gene

Orthologs for TAS2R4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAS2R4 35
  • 81.87 (n)
  • 70.27 (a)
TAS2R4 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R4 35
  • 82.44 (n)
  • 74.16 (a)
mouse
(Mus musculus)
Mammalia Tas2r108 35
  • 76.66 (n)
  • 67 (a)
Tas2r108 16
Tas2r108 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAS2R4 35
  • 99.78 (n)
  • 99.33 (a)
TAS2R4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r108 35
  • 74.97 (n)
  • 64.65 (a)
chicken
(Gallus gallus)
Aves TAS2R7 36
  • 23 (a)
OneToMany
Species with no ortholog for TAS2R4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R4 Gene

ENSEMBL:
Gene Tree for TAS2R4 (if available)
TreeFam:
Gene Tree for TAS2R4 (if available)

Paralogs for TAS2R4 Gene

genes like me logo Genes that share paralogs with TAS2R4: view

Variants for TAS2R4 Gene

Sequence variations from dbSNP and Humsavar for TAS2R4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2234000 - 141,778,709(+) AAATA(C/T)GGAAA reference, missense
rs2234001 - 141,778,774(+) GCAGT(C/G)TCTGG reference, missense
rs2234002 - 141,779,000(+) TATCA(A/G)TGAGG reference, missense
rs2233995 - 141,778,496(+) GCTTC(A/G)GTTAT reference, missense
rs2233998 - 141,778,508(+) CTATT(C/T)CTCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R4 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Variation tolerance for TAS2R4 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAS2R4 Gene

Disorders for TAS2R4 Gene

Relevant External Links for TAS2R4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R4

No disorders were found for TAS2R4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R4 Gene

Publications for TAS2R4 Gene

  1. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 2 3 4 67
  2. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3
  3. Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4. (PMID: 25844797) Pydi S.P. … Chelikani P. (Biochemistry 2015) 3
  4. The structure-function role of C-terminus in human bitter taste receptor T2R4 signaling. (PMID: 25858111) Upadhyaya J. … Chelikani P. (Biochim. Biophys. Acta 2015) 3
  5. Amino acid derivatives as bitter taste receptor (T2R) blockers. (PMID: 25059668) Pydi S.P. … Chelikani P. (J. Biol. Chem. 2014) 3

Products for TAS2R4 Gene

Sources for TAS2R4 Gene

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