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Aliases for TAS2R4 Gene

Aliases for TAS2R4 Gene

  • Taste Receptor, Type 2, Member 4 2 3
  • T2R4 3 4 6
  • Taste Receptor Type 2 Member 4 3
  • Candidate Taste Receptor T2R4 3

External Ids for TAS2R4 Gene

Summaries for TAS2R4 Gene

Entrez Gene Summary for TAS2R4 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R4 Gene

TAS2R4 (Taste Receptor, Type 2, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R4 Gene

  • Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Gene Wiki entry for TAS2R4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R4 Gene

Genomics for TAS2R4 Gene

Genomic Location for TAS2R4 Gene

Start:
141,778,442 bp from pter
End:
141,780,819 bp from pter
Size:
2,378 bases
Orientation:
Plus strand

Genomic View for TAS2R4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R4 Gene

Regulatory Elements for TAS2R4 Gene

Proteins for TAS2R4 Gene

  • Protein details for TAS2R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW5-TA2R4_HUMAN
    Recommended name:
    Taste receptor type 2 member 4
    Protein Accession:
    Q9NYW5
    Secondary Accessions:
    • Q645W5
    • Q75MV8

    Protein attributes for TAS2R4 Gene

    Size:
    299 amino acids
    Molecular mass:
    33841 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell

neXtProt entry for TAS2R4 Gene

Proteomics data for TAS2R4 Gene at MOPED

Post-translational modifications for TAS2R4 Gene

  • Glycosylation at Asn164, Asn165, and Asn169

Other Protein References for TAS2R4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R4 Gene

Domains for TAS2R4 Gene

Gene Families for TAS2R4 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TA2R4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • Q9NYW5
genes like me logo Genes that share domains with TAS2R4: view

Function for TAS2R4 Gene

Molecular function for TAS2R4 Gene

UniProtKB/Swiss-Prot Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Gene Ontology (GO) - Molecular Function for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R4: view

Phenotypes for TAS2R4 Gene

genes like me logo Genes that share phenotypes with TAS2R4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R4 Gene

Localization for TAS2R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R4 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R4 Gene COMPARTMENTS Subcellular localization image for TAS2R4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium --
GO:0016021 integral component of membrane IC 10761934
GO:0060170 ciliary membrane IEA --
genes like me logo Genes that share ontologies with TAS2R4: view

Pathways for TAS2R4 Gene

genes like me logo Genes that share pathways with TAS2R4: view

Pathways by source for TAS2R4 Gene

1 KEGG pathway for TAS2R4 Gene

Interacting Proteins for TAS2R4 Gene

Gene Ontology (GO) - Biological Process for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction TAS 10761934
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007585 respiratory gaseous exchange IEA --
GO:0050909 sensory perception of taste TAS 10761934
genes like me logo Genes that share ontologies with TAS2R4: view

Compounds for TAS2R4 Gene

(1) HMDB Compounds for TAS2R4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(15) BitterDB Compounds for TAS2R4 Gene

Compound Smiles Cas Number
amarogentin OC[C]1O[C@](O[C@]2OC=C3[C@](CCOC3=O)[C]2C=C)[C](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@](O)[C@]1O 21018-84-8
Arborescin CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O
Artemorin CC1=C/[C]2OC(=O)C(=C)[C@]2CCC(=C)[C](O)CC1
Azathioprine Cn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]
brucine COc1cc2N3C4[C@]5C(CC3=O)OCC=C6CN7CC[C@]4([C@]7C[C]56)c2cc1OC 357-57-3
Campher CC1(C)C2CCC1(C)C(=O)OC2=O
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
colchicine COC1=CC=C2C(=CC1=O)[C](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C
dapsone Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
denatonium benzoate CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 3734-33-6
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
Parthenolide CC1=C/CC[C@@]2(C)O[C]2[C]3OC(=O)C(=C)[C@]3CC1
Quassin COC1=C[C@](C)[C@]2C[C]3OC(=O)C[C]4C(=C(OC)C(=O)[C@]([C@@]34C)[C@@]2(C)C1=O)C 76-78-8
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
yohimbine COC(=O)[C]1[C@](O)CC[C]2CN3CCc4c([nH]c5ccccc45)[C@]3C[C]12
genes like me logo Genes that share compounds with TAS2R4: view

Transcripts for TAS2R4 Gene

mRNA/cDNA for TAS2R4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R4 Gene

Taste receptor, type 2, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R4 Gene

No ASD Table

Relevant External Links for TAS2R4 Gene

GeneLoc Exon Structure for
TAS2R4
ECgene alternative splicing isoforms for
TAS2R4

Expression for TAS2R4 Gene

mRNA expression in normal human tissues for TAS2R4 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.4) and Brain - Cerebellum (4.2).

SOURCE GeneReport for Unigene cluster for TAS2R4 Gene Hs.735690

mRNA Expression by UniProt/SwissProt for TAS2R4 Gene

Q9NYW5-TA2R4_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.
genes like me logo Genes that share expressions with TAS2R4: view

Orthologs for TAS2R4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R4 36
  • 99.78 (n)
  • 99.33 (a)
TAS2R4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R4 36
  • 81.87 (n)
  • 70.27 (a)
TAS2R4 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R4 36
  • 82.44 (n)
  • 74.16 (a)
mouse
(Mus musculus)
Mammalia Tas2r108 36
  • 76.66 (n)
  • 67 (a)
Tas2r108 16
Tas2r108 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r108 36
  • 74.97 (n)
  • 64.65 (a)
chicken
(Gallus gallus)
Aves TAS2R7 37
  • 23 (a)
OneToMany
Species with no ortholog for TAS2R4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R4 Gene

ENSEMBL:
Gene Tree for TAS2R4 (if available)
TreeFam:
Gene Tree for TAS2R4 (if available)

Paralogs for TAS2R4 Gene

genes like me logo Genes that share paralogs with TAS2R4: view

Variants for TAS2R4 Gene

Sequence variations from dbSNP and Humsavar for TAS2R4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2233990 -- 141,777,872(+) GAGGT(A/G)TTGGG upstream-variant-2KB
rs2233991 -- 141,777,933(+) TGAGG(C/T)TGAAA upstream-variant-2KB
rs2233992 -- 141,778,365(+) TTGCC(A/G)TGCTG upstream-variant-2KB
rs2233993 -- 141,778,386(+) AAAAG(A/G)AGATG upstream-variant-2KB
rs2233994 -- 141,778,479(+) CCTCA(A/G)TGAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R4 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Relevant External Links for TAS2R4 Gene

HapMap Linkage Disequilibrium report
TAS2R4

Disorders for TAS2R4 Gene

No disorders were found for TAS2R4 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R4 Gene

Publications for TAS2R4 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 2 3 4
  3. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  4. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4

Products for TAS2R4 Gene

Sources for TAS2R4 Gene

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