TAS2R4 Gene
protein-coding GIFtS: 49
GCID: GC07P141479
|
|
taste receptor, type 2, member 4
| |
Aliases
for TAS2R4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 2, Member 41 2 | | T2R41 2 3 5 | | Candidate Taste Receptor T2R42 | | Taste Receptor Type 2 Member 42 |
Export aliases for TAS2R4 gene to outside databasesPrevious GC identifers: GC07P139749 GC07P140808 GC07P140885 GC07P140931 GC07P141124 GC07P135774 |
Summaries
for TAS2R4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R4:
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptorsuperfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. Theseapparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. Thisgene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci thatinfluence bitter perception. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bittercompounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cationchannel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentrationand stimulates ciliary beat frequency
Gene Wiki entry for TAS2R4
|
Genomic Views
for TAS2R4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R4 gene promoter:
GR TBP Bach2 Nkx2-5 LCR-F1 c-Rel Cart-1 GR-alpha Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.3-q32 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q31.3-q32TAS2R4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P141479: view genomic region
(about GC identifiers)
Start:
|
141,478,242 bp from pter |
End:
|
141,479,235 bp from pter |
Size:
|
994 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 140,816,001-140,816,900 |
|
Proteins
for TAS2R4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5 (See
protein sequence)Recommended Name: Taste receptor type 2 member 4 Size: 299 amino acids; 33841 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airwayepithelial cells, localizes to motile cilia
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell
Secondary accessions: Q645W5 Q75MV8Explore the universe of human proteins at neXtProt for TAS2R4: NX_Q9NYW5
TAS2R4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_058640.1
ENSEMBL proteins: ENSP00000247881
Human Recombinant Protein Products for TAS2R4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TAS2R4 for ontologies About GeneDecksing
TAS2R4 Antibody Products:
Assay Products for TAS2R4: |
Protein
Domains /
Families
for TAS2R4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NYW5ProtoNet protein and cluster: Q9NYW5 UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Similarity: Belongs to the G-protein coupled receptor T2R family |
Function
for TAS2R4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TA2R4_HUMAN, Q9NYW5Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bittercompounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cationchannel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentrationand stimulates ciliary beat frequency Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TAS2R4 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for TAS2R4:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TAS2R4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R4 |
|
Pathways & Interactions
for TAS2R4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Taste transduction | | | 2 | Sweet Taste Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R4
1 
Kegg Pathway (Kegg details for TAS2R4):
TAS2R4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TAS2R4 (ENSP000002478814) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TAS2R4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS2R4
1 HMDB Compound for TAS2R4 About this table
10/15 BitterDB Bitter Compounds for TAS2R4 (see all 15) About this table
| Compound | SMILES |
CAS
# |
|---|
| amarogentin | OC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O | 21018-84-8 | | Arborescin | CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O | -- | | Artemorin | CC1=C/[C@H]2OC(=O)C(=C)[C@@H]2CCC(=C)[C@H](O)CC1 | -- | | Azathioprine | Cn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-] | -- | | brucine | COc1cc2N3C4[C@@H]5C(CC3=O)OCC=C6CN7CC[C@]4([C@@H]7C[C@H]56)c2cc1OC | 357-57-3 | | Campher | CC1(C)C2CCC1(C)C(=O)OC2=O | -- | | Chlorpheniramine | CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2 | -- | | colchicine | COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C | -- | | dapsone | Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 | -- | | denatonium benzoate | CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 | 3734-33-6 |
Search CenterWatch for drugs/clinical trials and news about TAS2R4 / TA2R4
|
Transcripts
for TAS2R4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS2R4 gene: NM_016944.1 Unigene Cluster for TAS2R4: Taste receptor, type 2, member 4 Hs.735690 Unigene Representative Sequence: AL8325131 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000247881(uc003vwq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS2R4 (NM_016944) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R4 |
Additional cDNA sequence: AL832513.1 BC130439.1 BC136508.1 1 DOTS entry: DT.65286284 6 AceView cDNA sequences: AL832513 NM_016944 AW590303 AI652891 AW197234 BQ378653
GeneLoc Exon Structure
|
Expression
for TAS2R4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS2R4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAATGGAA
About this image
See TAS2R4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS2R4
SOURCE GeneReport for Unigene cluster: Hs.735690
UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively ingustducin-positive cells. Expressed on airway ciliated epithelium
SABiosciences Custom PCR Arrays for TAS2R4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R4
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R4 |
Orthologs
for TAS2R4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAS2R4 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
Q2AB82_CHICK6Q2AB81_CHICK6 |
Taste receptor type 2 |
29(a)22(a) |
1 ↔ 1possible ortholog |
1(195761188-195762123) 3(112675246-112676211) |
ENSEMBL Gene Tree for TAS2R4 (if available)
TreeFam Gene Tree for TAS2R4 (if available) |
Paralogs
for TAS2R4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAS2R4 gene
- TAS2R52 TAS2R412 TAS2R462 TAS2R162 TAS2R32 TAS2R142 TAS2R432 TAS2R392
- TAS2R382 TAS2R422 TAS2R92 TAS2R302 TAS2R12 TAS2R192 TAS2R72 TAS2R202
- TAS2R82 TAS2R132 TAS2R402 TAS2R102 TAS2R502 TAS2R602 TAS2R312
18/25 SIMAP similar genes for TAS2R4 using alignment to 3 protein entries: TA2R4_HUMAN (see all proteins)
(see all similar genes):Hosa(Adygei)-T2R4 Hosa(Biaka)-T2R4 Hosa(Biaka)-T2R40 Hosa(Japanese)-T2R40 TAS2R40 TAS2R39
Hosa(Biaka)-T2R2 Hosa(Japanese)-T2R39 Hosa(Adygei)-T2R3 Hosa(Biaka)-T2R10 Hosa(Biaka)-T2R13 Hosa(Biaka)-T2R3
Hosa(Japanese)-T2R13 TAS2R3 Hosa(Adygei)-T2R10 Hosa(Japanese)-T2R10 TAS2R10 TAS2R9
TAS2R4 for paralogs About GeneDecksing
|
Genomic Variants
for TAS2R4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAS2R4 (141478242 - 141479235 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAS2R4
1 CNV: 47923 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R4 |
|
Disorders
/ Diseases
for TAS2R4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TAS2R4 for disorders About MalaCards
TAS2R4 for disorders About GeneDecksing
OMIM gene information: 604869
OMIM disorders: --
Export disorders for TAS2R4 gene to outside databases
|
Publications
for TAS2R4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS2R4 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TAS2R4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
- T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2, 3 Chandrashekar J.... Ryba N.J.P. (2000)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Behavioral analysis of Drosophila transformants expres sing human taste receptor genes in the gustatory receptor neurons. (PubMed id 22794107)1 Adachi R....Isono K. (2012)
- Motile cilia of human airway epithelia are chemosensory. (PubMed id 19628819)2 Shah A.S.... Welsh M.J. (2009)
- Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
|
External Searches for TAS2R4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS2R4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS2R4 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt119.shtml |
|
| | |
About This Section
| Patent Information for TAS2R4 gene:
Search GeneIP for patents involving TAS2R4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R4 |
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