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Aliases for TAS2R39 Gene

Aliases for TAS2R39 Gene

  • Taste 2 Receptor Member 39 2 3 5
  • Taste Receptor, Type 2, Member 39 2 3
  • Taste Receptor Type 2 Member 57 3 4
  • T2R39 3 4
  • T2R57 3 4
  • Taste Receptor Type 2 Member 39 3

External Ids for TAS2R39 Gene

Previous GeneCards Identifiers for TAS2R39 Gene

  • GC00U991248
  • GC07P142274
  • GC07P142351
  • GC07P142397
  • GC07P142590
  • GC07P142880
  • GC07P137219
  • GC07P143185
  • GC07P143253
  • GC07P143400

Summaries for TAS2R39 Gene

Entrez Gene Summary for TAS2R39 Gene

  • The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]

GeneCards Summary for TAS2R39 Gene

TAS2R39 (Taste 2 Receptor Member 39) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R40.

UniProtKB/Swiss-Prot for TAS2R39 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R39 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R39 Gene

Genomics for TAS2R39 Gene

Regulatory Elements for TAS2R39 Gene

Enhancers for TAS2R39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G143012 0.8 ENCODE 11.1 -168.0 -167966 4.9 CTCF PKNOX1 RAD21 YY1 FOSL1 ZNF316 GATA2 SMC3 FOS NFE2 OR9P1P OR6V1 TAS2R39 KEL TRBV11-2 OR9A2
GH07G143042 0.8 ENCODE 10.9 -140.4 -140400 1.8 FOXA2 ZNF48 RARA SCRT2 ETV6 CREM HMG20B JUNB CTCF SOX13 TAS2R39 GSTK1 OR9P1P LOC105375544
GH07G143120 0.6 ENCODE 11.3 -62.6 -62575 1.3 PKNOX1 GATA3 JUND JUNB NR3C1 ATF2 OR6V1 TAS2R39 OR9P1P KEL C7orf34 TRPV5 TMEM139 TCAF2 GSTK1 PIP
GH07G143098 0.6 FANTOM5 11.1 -84.5 -84458 0.4 JUND POLR2A MLLT1 EZH2 OR6V1 OR9P1P TAS2R39 PIP OR6W1P
GH07G143244 1 FANTOM5 Ensembl ENCODE 6 +61.9 61877 1.3 MCM7 PRDM6 ZNF266 FOS FAM131B TMEM139 CASP2 LOC105375545 RN7SL535P ZYX LOC100507507 OR9A2 TAS2R39 TRPV6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R39 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R39 Gene

Chromosome:
7
Start:
143,183,419 bp from pter
End:
143,184,435 bp from pter
Size:
1,017 bases
Orientation:
Plus strand

Genomic View for TAS2R39 Gene

Genes around TAS2R39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R39 Gene

Proteins for TAS2R39 Gene

  • Protein details for TAS2R39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59534-T2R39_HUMAN
    Recommended name:
    Taste receptor type 2 member 39
    Protein Accession:
    P59534
    Secondary Accessions:
    • A4FUI7
    • Q3ZCN6
    • Q645W4

    Protein attributes for TAS2R39 Gene

    Size:
    338 amino acids
    Molecular mass:
    38626 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
    SequenceCaution:
    • Sequence=AAM19321.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAS2R39 Gene

neXtProt entry for TAS2R39 Gene

Post-translational modifications for TAS2R39 Gene

  • Glycosylation at isoforms=185 and posLast=194194
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R39 Gene

Domains & Families for TAS2R39 Gene

Gene Families for TAS2R39 Gene

Protein Domains for TAS2R39 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59534

UniProtKB/Swiss-Prot:

T2R39_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R39: view

Function for TAS2R39 Gene

Molecular function for TAS2R39 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R39: view
genes like me logo Genes that share phenotypes with TAS2R39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R39 Gene

Localization for TAS2R39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R39 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R39 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R39: view

Pathways & Interactions for TAS2R39 Gene

genes like me logo Genes that share pathways with TAS2R39: view

Pathways by source for TAS2R39 Gene

Gene Ontology (GO) - Biological Process for TAS2R39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R39: view

No data available for SIGNOR curated interactions for TAS2R39 Gene

Drugs & Compounds for TAS2R39 Gene

(10) Drugs for TAS2R39 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma Cyclooxygenase inhibitor; may be selective for COX-3 1026
Chloramphenicol Approved, Vet_approved Pharma 7
chloroquine Approved, Vet_approved Pharma Agonist 149
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 115
Diphenidol Approved, Withdrawn Pharma 1

(8) Additional Compounds for TAS2R39 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-Epicatechin gallate,Ecg,Epicatechin gallate
(-)-Epicatechin,EC,Epicatechin
(-)-epigallocatechin (EGC),epigallocatechin,Gallocatechol
(+/-) Equol
amarogentin
21018-84-8
genes like me logo Genes that share compounds with TAS2R39: view

Transcripts for TAS2R39 Gene

mRNA/cDNA for TAS2R39 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R39 Gene

No ASD Table

Relevant External Links for TAS2R39 Gene

GeneLoc Exon Structure for
TAS2R39
ECgene alternative splicing isoforms for
TAS2R39

Expression for TAS2R39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R39 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R39 Gene:

TAS2R39

SOURCE GeneReport for Unigene cluster for TAS2R39 Gene:

Hs.553660

mRNA Expression by UniProt/SwissProt for TAS2R39 Gene:

P59534-T2R39_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R39 Gene

Orthologs for TAS2R39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R39 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia TAS2R39 34 35
  • 83.6 (n)
cow
(Bos Taurus)
Mammalia TAS2R39 34
  • 78.11 (n)
mouse
(Mus musculus)
Mammalia Tas2r139 34 16 35
  • 72.86 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r139 34
  • 69.27 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R39 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS2R7 35
  • 23 (a)
OneToMany
Species where no ortholog for TAS2R39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R39 Gene

ENSEMBL:
Gene Tree for TAS2R39 (if available)
TreeFam:
Gene Tree for TAS2R39 (if available)

Paralogs for TAS2R39 Gene

Variants for TAS2R39 Gene

Sequence variations from dbSNP and Humsavar for TAS2R39 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000175649 -- 143,184,610(+) TCTTA(A/G)TGGTA downstream-variant-500B
rs1000249120 -- 143,184,242(+) CAATG(C/G)AGTTG reference, missense
rs1000510219 -- 143,183,056(+) GTGTG(C/T)ATGTG upstream-variant-2KB
rs1001951185 -- 143,183,765(+) AATAA(C/G)TTTTA reference, missense
rs1002364583 -- 143,181,514(+) ACCCT(A/G)CACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R39 Gene

Variant ID Type Subtype PubMed ID
dgv11660n54 CNV loss 21841781
dgv11661n54 CNV loss 21841781
dgv11663n54 CNV loss 21841781
dgv1977e212 CNV loss 25503493
dgv432n21 CNV loss 19592680
dgv6698n100 CNV loss 25217958
esv2675537 CNV deletion 23128226
esv2676270 CNV deletion 23128226
esv2764005 CNV loss 21179565
esv29078 CNV loss 19812545
esv3542554 CNV deletion 23714750
esv3615300 CNV loss 21293372
esv3615302 CNV loss 21293372
esv3615303 CNV loss 21293372
nsv465175 CNV loss 19166990
nsv465176 CNV loss 19166990
nsv608657 CNV loss 21841781
nsv608676 CNV loss 21841781
nsv608680 CNV loss 21841781

Variation tolerance for TAS2R39 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R39 Gene

Disorders for TAS2R39 Gene

Relevant External Links for TAS2R39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R39

No disorders were found for TAS2R39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R39 Gene

Publications for TAS2R39 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
  4. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 4 64
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4 64

Products for TAS2R39 Gene

Sources for TAS2R39 Gene

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