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Aliases for TAS2R39 Gene

Aliases for TAS2R39 Gene

  • Taste Receptor, Type 2, Member 39 2 3
  • Taste Receptor Type 2 Member 57 3 4
  • T2R39 3 4
  • T2R57 3 4
  • Taste Receptor Type 2 Member 39 3

External Ids for TAS2R39 Gene

Summaries for TAS2R39 Gene

GeneCards Summary for TAS2R39 Gene

TAS2R39 (Taste Receptor, Type 2, Member 39) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R39 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R39 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R39 Gene

Genomics for TAS2R39 Gene

Genomic Location for TAS2R39 Gene

Start:
143,183,419 bp from pter
End:
143,184,435 bp from pter
Size:
1,017 bases
Orientation:
Plus strand

Genomic View for TAS2R39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R39 Gene

Regulatory Elements for TAS2R39 Gene

Proteins for TAS2R39 Gene

  • Protein details for TAS2R39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59534-T2R39_HUMAN
    Recommended name:
    Taste receptor type 2 member 39
    Protein Accession:
    P59534
    Secondary Accessions:
    • A4FUI7
    • Q3ZCN6
    • Q645W4

    Protein attributes for TAS2R39 Gene

    Size:
    338 amino acids
    Molecular mass:
    38626 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli
    SequenceCaution:
    • Sequence=AAM19321.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAS2R39 Gene

neXtProt entry for TAS2R39 Gene

Proteomics data for TAS2R39 Gene at MOPED

Post-translational modifications for TAS2R39 Gene

  • Glycosylation at Asn185 and Asn194

Other Protein References for TAS2R39 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R39 Gene

Domains for TAS2R39 Gene

Gene Families for TAS2R39 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R39 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

T2R39_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • P59534
genes like me logo Genes that share domains with TAS2R39: view

Function for TAS2R39 Gene

Molecular function for TAS2R39 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R39: view
genes like me logo Genes that share phenotypes with TAS2R39: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R39 Gene

Localization for TAS2R39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R39 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R39 Gene COMPARTMENTS Subcellular localization image for TAS2R39 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R39: view

Pathways for TAS2R39 Gene

genes like me logo Genes that share pathways with TAS2R39: view

Pathways by source for TAS2R39 Gene

Interacting Proteins for TAS2R39 Gene

Gene Ontology (GO) - Biological Process for TAS2R39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R39: view

Compounds for TAS2R39 Gene

(18) BitterDB Compounds for TAS2R39 Gene

Compound Smiles Cas Number
(-)-Epicatechin gallate,Ecg,Epicatechin gallate Oc1cc(O)c2C[C@](OC(=O)c3cc(O)c(O)c(O)c3)[C](Oc2c1)c4ccc(O)c(O)c4
(-)-Epicatechin,EC,Epicatechin O[C@]1Cc2c(O)cc(O)cc2O[C@]1c3ccc(O)c(O)c3
(-)-epigallocatechin (EGC),epigallocatechin,Gallocatechol O[C@]1Cc2c(O)cc(O)cc2O[C@]1c3cc(O)c(O)c(O)c3
(+/-) Equol Oc1:c:c:c(:c:c:1)C2COc3:c:c(O):c:c:c:3C2
Acetaminophen CC(=O)Nc1ccc(O)cc1
amarogentin OC[C]1O[C@](O[C@]2OC=C3[C@](CCOC3=O)[C]2C=C)[C](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@](O)[C@]1O 21018-84-8
chloramphenicol OC[C@](NC(=O)C(Cl)Cl)[C](O)c1ccc(cc1)[N+](=O)[O-]
chloroquine CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 54-05-7
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
colchicine COC1=CC=C2C(=CC1=O)[C](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C
Coumestrol Oc1ccc2c(OC(=O)c3c2oc4cc(O)ccc34)c1
denatonium benzoate CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 3734-33-6
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
Epigallocatechin gallate,egcg Oc1cc(O)c2C[C@](OC(=O)c3cc(O)c(O)c(O)c3)[C](Oc2c1)c4cc(O)c(O)c(O)c4
Genistein Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
Genistin OC[C]1O[C@](Oc2cc(O)c3C(=O)C(=COc3c2)c4ccc(O)cc4)[C](O)[C@](O)[C@]1O
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
Thiamine Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1
genes like me logo Genes that share compounds with TAS2R39: view

Transcripts for TAS2R39 Gene

mRNA/cDNA for TAS2R39 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R39 Gene

No ASD Table

Relevant External Links for TAS2R39 Gene

GeneLoc Exon Structure for
TAS2R39
ECgene alternative splicing isoforms for
TAS2R39

Expression for TAS2R39 Gene

mRNA expression in normal human tissues for TAS2R39 Gene

SOURCE GeneReport for Unigene cluster for TAS2R39 Gene Hs.553660

mRNA Expression by UniProt/SwissProt for TAS2R39 Gene

P59534-T2R39_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R39: view

Orthologs for TAS2R39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R39 36
  • 99.7 (n)
  • 99.41 (a)
TAS2R39 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R39 36
  • 78.11 (n)
  • 64.2 (a)
dog
(Canis familiaris)
Mammalia TAS2R39 36
  • 83.6 (n)
  • 72.56 (a)
TAS2R39 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r139 36
  • 72.86 (n)
  • 57.77 (a)
Tas2r139 16
Tas2r139 37
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia T2R39 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r139 36
  • 69.27 (n)
  • 55.05 (a)
chicken
(Gallus gallus)
Aves TAS2R7 37
  • 23 (a)
OneToMany
Species with no ortholog for TAS2R39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R39 Gene

ENSEMBL:
Gene Tree for TAS2R39 (if available)
TreeFam:
Gene Tree for TAS2R39 (if available)

Paralogs for TAS2R39 Gene

genes like me logo Genes that share paralogs with TAS2R39: view

Variants for TAS2R39 Gene

Sequence variations from dbSNP and Humsavar for TAS2R39 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4103817 -- 143,184,192(+) CACAT(A/G)GGGGC missense, reference
rs4726600 -- 143,184,447(+) CCCAA(A/G)AAGAC downstream-variant-500B
rs6964922 -- 143,182,716(+) GGGGA(C/T)ATAAA upstream-variant-2KB
rs34169190 - 143,184,007(-) TTTCT(C/T)AGTGG reference, missense
rs35474877 - 143,183,996(-) AGTTG(A/G)AGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R39 Gene

Variant ID Type Subtype PubMed ID
nsv465175 CNV Loss 19166990
dgv432n21 CNV Loss 19592680
esv2675537 CNV Deletion 23128226
nsv465176 CNV Loss 19166990
esv2676270 CNV Deletion 23128226
esv29078 CNV Loss 19812545

Relevant External Links for TAS2R39 Gene

HapMap Linkage Disequilibrium report
TAS2R39

Disorders for TAS2R39 Gene

No disorders were found for TAS2R39 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R39 Gene

Publications for TAS2R39 Gene

  1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 3 4
  2. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  3. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R39 Gene

Sources for TAS2R39 Gene

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