Aliases for TAS2R39 Gene
Aliases for TAS2R39 Gene
External Ids for TAS2R39 Gene
- HGNC: 18886
- Entrez Gene: 259285
- Ensembl: ENSG00000236398
- UniProtKB: P59534
Previous GeneCards Identifiers for TAS2R39 Gene
- GC00U991248
- GC07P142274
- GC07P142351
- GC07P142397
- GC07P142590
- GC07P142880
- GC07P137219
- GC07P143185
- GC07P143253
- GC07P143400
- GC07P143547
- GC07P143681
Summaries for TAS2R39 Gene
-
The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
GeneCards Summary for TAS2R39 Gene
TAS2R39 (Taste 2 Receptor Member 39) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R40.
UniProtKB/Swiss-Prot for TAS2R39 Gene
-
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Additional gene information for TAS2R39 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R39 Gene
Genomics for TAS2R39 Gene
GeneHancer (GH) Regulatory Elements for TAS2R39 Gene
Promoters and enhancers for TAS2R39 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07I143042 | Enhancer | 0.7 | ENCODE | 10.9 | -140.4 | -140399 | 1.8 | SOX13 FOXA2 BATF ZNF48 RARA RERE NR2F6 CREM TCF7L2 GATAD2A | TAS2R39 GSTK1 OR9P1P LOC105375544 | |
| GH07I143012 | Enhancer | 0.6 | ENCODE | 11.1 | -168.0 | -167965 | 4.9 | SRF PKNOX1 MAFG ZNF316 JUND POLR2A NFE2 EMSY MAFK | OR9P1P OR6V1 TAS2R39 KEL TRBV11-2 OR9A2 | |
| GH07I143244 | Enhancer | 0.9 | FANTOM5 Ensembl ENCODE | 6.1 | +61.9 | 61877 | 1.3 | MITF MCM7 PRDM6 ZNF266 FOSL2 | GSTK1 CASP2 RN7SL535P FAM131B TMEM139 LOC105375545 LOC154761 LOC100507507 ZYX TCAF2 | |
| GH07I143120 | Enhancer | 0.4 | ENCODE | 11.3 | -62.6 | -62575 | 1.3 | PKNOX1 JUND GATA3 | OR6V1 TAS2R39 OR9P1P KEL LLCFC1 TRPV5 TMEM139 TCAF2 GSTK1 PIP | |
| GH07I143098 | Enhancer | 0.3 | FANTOM5 | 11.1 | -84.5 | -84457 | 0.4 | SETDB1 | OR6V1 OR9P1P TAS2R39 PIP OR6W1P |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TAS2R39 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TAS2R39 Gene
Genomic Locations for TAS2R39 Gene
- chr7:143,183,419-143,184,435
- (GRCh38/hg38)
- Size:
- 1,017 bases
- Orientation:
- Plus strand
- chr7:142,880,512-142,881,528
- (GRCh37/hg19)
Genomic View for TAS2R39 Gene
Genes around TAS2R39 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q34 by Ensembl
- 7q34 by Entrez Gene
- 7q34 by HGNC
TAS2R39 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAS2R39 Gene
Proteins for TAS2R39 Gene
-
Protein details for TAS2R39 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59534-T2R39_HUMAN
- Recommended name:
- Taste receptor type 2 member 39
- Protein Accession:
- P59534
- A4FUI7
- Q3ZCN6
- Q645W4
Protein attributes for TAS2R39 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 38626 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
- SequenceCaution:
-
- Sequence=AAM19321.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};
Post-translational modifications for TAS2R39 Gene
- Glycosylation at posLast=185185 and posLast=194194
Other Protein References for TAS2R39 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Assay Products
No data available for DME Specific Peptides for TAS2R39 Gene
Domains & Families for TAS2R39 Gene
Gene Families for TAS2R39 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for TAS2R39 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAS2R39 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P59534- Family:
-
- Belongs to the G-protein coupled receptor T2R family.
Function for TAS2R39 Gene
Molecular function for TAS2R39 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Phenotypes From GWAS Catalog for TAS2R39 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0033038 | bitter taste receptor activity | IDA | 20022913 |
Phenotypes for TAS2R39 Gene
- GenomeRNAi human phenotypes for TAS2R39:
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R39 Gene
Localization for TAS2R39 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAS2R39 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IC,IBA | 20022913 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R39 Gene
Pathways & Interactions for TAS2R39 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Taste transduction | ||
| 3 | Peptide ligand-binding receptors | ||
Pathways by source for TAS2R39 Gene
6 Reactome pathways for TAS2R39 Gene
1 KEGG pathway for TAS2R39 Gene
Interacting Proteins for TAS2R39 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 20022913 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0050896 | response to stimulus | IEA | -- |
| GO:0050909 | sensory perception of taste | IEA | -- |
No data available for SIGNOR curated interactions for TAS2R39 Gene
Drugs & Compounds for TAS2R39 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Acetaminophen | Approved | Pharma | 1014 | |||
| Chloramphenicol | Approved, Vet_approved | Pharma | 7 | |||
| chloroquine | Approved, Investigational, Vet_approved | Pharma | Agonist | 154 | ||
| Colchicine | Approved | Pharma | Antagonist | Tubulin Inhibitor | 118 | |
| Diphenidol | Approved, Investigational, Withdrawn | Pharma | 1 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (-)-Epicatechin gallate,Ecg,Epicatechin gallate |
|
|
|
|||
| (-)-Epicatechin,EC,Epicatechin |
|
|
|
|||
| (-)-epigallocatechin (EGC),epigallocatechin,Gallocatechol |
|
|
|
|||
| (+/-) Equol |
|
|
|
|||
| amarogentin |
|
21018-84-8 |
|
|
Transcripts for TAS2R39 Gene
mRNA/cDNA for TAS2R39 Gene
- (1) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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OriGene CRISPR knockouts for TAS2R39
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Vectors and viruses for KO, Activation, Repression, and more
-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TAS2R39 gene related products
- orf clones - Search results for available TAS2R39 gene related products
- Applied Biological Materials Clones for TAS2R39
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TAS2R39 Gene
NURSA nuclear receptor signaling pathways regulating expression of TAS2R39 Gene:
TAS2R39SOURCE GeneReport for Unigene cluster for TAS2R39 Gene:
Hs.553660mRNA Expression by UniProt/SwissProt for TAS2R39 Gene:
P59534-T2R39_HUMAN
Tissue specificity:
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Primer Products
-
OriGene qPCR primer pairs for TAS2R39
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R39 Gene
Orthologs for TAS2R39 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAS2R39 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TAS2R39 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TAS2R39 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tas2r139 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tas2r139 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | T2R39 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TAS2R7 34 |
|
OneToMany |
- Species where no ortholog for TAS2R39 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TAS2R39 Gene
Paralogs for TAS2R39 Gene
(28) SIMAP similar genes for TAS2R39 Gene using alignment to 1 proteins:
- Hosa(Japanese)-T2R39
- Hosa(Japanese)-T2R40
- Hosa(Biaka)-T2R40
- TAS2R40
- Hosa(Japanese)-T2R13
- Hosa(Biaka)-T2R4
- Hosa(Biaka)-T2R13
- Hosa(Adygei)-T2R4
- TAS2R13
- TAS2R4
- TAS2R1
- TAS2R43
- TAS2R31
- TAS2R46
- Hosa(Japanese)-T2R14
- TAS2R10
- TAS2R9
- TAS2R8
- TAS2R7
- Hosa(Biaka)-T2R7
- Hosa(Biaka)-T2R3
- Hosa(Adygei)-T2R7
- Hosa(Adygei)-T2R3
- TAS2R14
- TAS2R3
- TAS2R60
- TAS2R42
- TAS2R41
Variants for TAS2R39 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000175649 | -- | 143,184,610(+) | G/A | downstream_transcript_variant | |
| rs1000249120 | -- | 143,184,242(+) | C/G | coding_sequence_variant, missense_variant | |
| rs1000510219 | -- | 143,183,056(+) | T/C | upstream_transcript_variant | |
| rs1001951185 | -- | 143,183,765(+) | G/A/C | coding_sequence_variant, missense_variant | |
| rs1002364583 | -- | 143,181,514(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11660n54 | CNV | loss | 21841781 |
| dgv11661n54 | CNV | loss | 21841781 |
| dgv11663n54 | CNV | loss | 21841781 |
| dgv1977e212 | CNV | loss | 25503493 |
| dgv432n21 | CNV | loss | 19592680 |
| dgv6698n100 | CNV | loss | 25217958 |
| esv2675537 | CNV | deletion | 23128226 |
| esv2676270 | CNV | deletion | 23128226 |
| esv2764005 | CNV | loss | 21179565 |
| esv29078 | CNV | loss | 19812545 |
| esv3542554 | CNV | deletion | 23714750 |
| esv3615300 | CNV | loss | 21293372 |
| esv3615302 | CNV | loss | 21293372 |
| esv3615303 | CNV | loss | 21293372 |
| nsv465175 | CNV | loss | 19166990 |
| nsv465176 | CNV | loss | 19166990 |
| nsv608657 | CNV | loss | 21841781 |
| nsv608676 | CNV | loss | 21841781 |
| nsv608680 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.70;
32.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAS2R39 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAS2R39
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R39 Gene
Disorders for TAS2R39 Gene
Additional Disease Information for TAS2R39
No disorders were found for TAS2R39 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R39 Gene
Publications for TAS2R39 Gene
- Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 58
- The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. (PMID: 12379855) Bufe B … Meyerhof W (Nature genetics 2002) 2 4 58
- Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee RF (The Journal of biological chemistry 2002) 3 4 58
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- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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- Search ViGene Biosciences for TAS2R39
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for TAS2R39 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TAS2R39
- Horizon Cell Lines for TAS2R39
- genomics-online: cdna clones - Search results for available TAS2R39 gene related products
- orf clones - Search results for available TAS2R39 gene related products
- genomics-online: gRNA clones - Search results for available TAS2R39 gene related products
- genomics-online: primer clones - Search results for available TAS2R39 gene related products
- genomics-online: shRNA clones - Search results for available TAS2R39 gene related products
Sources for TAS2R39 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
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- (16) MGI
- (17) IUBMB
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew