Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R39 Gene

protein-coding   GIFtS: 49
GCID: GC07P142880

Taste Receptor, Type 2, Member 39
  Search for TAS2R39
at
MalaCards
 

Aliases
for TAS2R39 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Taste Receptor, Type 2, Member 391 2
Taste Receptor Type 2 Member 572 3
T2R392 3
T2R572 3
Taste Receptor Type 2 Member 392

External Ids:    HGNC: 188861   Entrez Gene: 2592852   Ensembl: ENSG000002363987   UniProtKB: P595343   

Export aliases for TAS2R39 gene to outside databases

Previous GC identifers: GC00U991248 GC07P142274 GC07P142351 GC07P142397 GC07P142590 GC07P137219


Summaries
for TAS2R39 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for TAS2R39 Gene: 
TAS2R39 (taste receptor, type 2, member 39) is a protein-coding gene. Among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R39 Gene


Genomic Views
for TAS2R39 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R39 gene promoter:
         AML1a   HTF   FOXD3   FOXL1   POU2F1   FOXO4   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAS2R39 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TAS2R39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R39 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142880:  view genomic region     (about GC identifiers)

Start:
 142,880,512 bp from pter      End:
 142,881,528 bp from pter
Size:
 1,017 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,282,647-142,283,663     

Proteins
for TAS2R39 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534 (See protein sequence)
Recommended Name: Taste receptor type 2 member 39  
Size: 338 amino acids; 38626 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Sequence caution: Sequence=AAM19321.1; Type=Frameshift; Positions=323;
1 PDB 3D structure from and Proteopedia for TAS2R39:
2GFZ (3D)    
Secondary accessions: A4FUI7 Q3ZCN6 Q645W4

Explore the universe of human proteins at neXtProt for TAS2R39: NX_P59534

Explore proteomics data for TAS2R39 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59534

    • TAS2R39 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAS2R39 Protein Expression
    REFSEQ proteins: NP_795362.2  
    ENSEMBL proteins: 
     ENSP00000405095  
    Reactome Protein details: P59534
    Human Recombinant Protein Products for TAS2R39: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TAS2R39
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TAS2R39
    GenScript Custom Purified and Recombinant Proteins Services for TAS2R39
    Novus Biologicals TAS2R39 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAS2R39 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    TAS2R39 for ontologies           About GeneDecksing



    TAS2R39 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TAS2R39
    GenScript Custom Superior Antibodies Services for TAS2R39
    Novus Biologicals TAS2R39 Antibody
    Abcam antibodies for TAS2R39
    Cloud-Clone Corp. Antibodies for TAS2R39 
    Search ThermoFisher Antibodies for TAS2R39
    LSBio Antibodies in human, mouse, rat for TAS2R39 

    Assay Products for TAS2R39: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAS2R39
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAS2R39
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAS2R39 
    Cloud-Clone Corp. CLIAs for TAS2R39

    Protein Domains /
    Families
    for TAS2R39 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R39 
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59534

    ProtoNet protein and cluster: P59534

    1 Blocks protein domain: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534
    Similarity: Belongs to the G-protein coupled receptor T2R family


    TAS2R39 for domains           About GeneDecksing


    Function
    for TAS2R39 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R39_HUMAN, P59534
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    TAS2R39 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAS2R39:
     Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAS2R39 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAS2R39

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAS2R39 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAS2R39 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAS2R39
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TAS2R39
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAS2R39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R39

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TAS2R39
    Sirion Biotech Customized adenovirus for overexpression of TAS2R39

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TAS2R39 (see all 6)
    OriGene ORF clones in mouse, rat for TAS2R39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAS2R39 (NM_176881)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAS2R39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R39
    Sirion Biotech Customized lentivirus for stable overexpression of TAS2R39 
                         Customized lentivirus expression plasmids for stable overexpression of TAS2R39 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TAS2R39
    Search LifeMap BioReagents cell lines for TAS2R39
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39


    Pathways & Interactions
    for TAS2R39 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAS2R39 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class C/3 (Metabotropic glutamate/pheromone receptors)
    		Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    		Taste transduction0.45
    2Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.55
    		GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.71
    		G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for TAS2R39 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for TAS2R39):
        Taste transduction


    TAS2R39 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R39

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TAS2R39 (ENSP000004050954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAT3ENSP000003813394STRING: ENSP00000381339
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050909sensory perception of taste IEA--

    TAS2R39 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAS2R39 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAS2R39 (T2R39)

    10/18 BitterDB Bitter Compounds for TAS2R39 (see all 18) About this table
    CompoundSMILES CAS #
    (+/-) EquolOc1:c:c:c(:c:c:1)C2COc3:c:c(O):c:c:c:3C2--
    (-)-Epicatechin gallate,Ecg,Epicatechin gallateOc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4--
    (-)-Epicatechin,EC,EpicatechinO[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3--
    (-)-epigallocatechin (EGC),epigallocatechin,Gallocatechol O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3--
    AcetaminophenCC(=O)Nc1ccc(O)cc1--
    amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
    chloramphenicolOC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-]--
    chloroquineCCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc1254-05-7
    ChlorpheniramineCN(C)CCC(c1ccc(Cl)cc1)c2ccccn2--
    colchicineCOC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C--


    Search CenterWatch for drugs/clinical trials and news about TAS2R39 / T2R39

    Transcripts
    for TAS2R39 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TAS2R39 gene: 
    NM_176881.2  

    Unigene Cluster for TAS2R39:

    Taste receptor, type 2, member 39
    Hs.553660
    Unigene Representative Sequence: NM_176881
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000446620(uc011ksw.2)
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAS2R39
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TAS2R39
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAS2R39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R39
    Clone
    Products:             		 OriGene clones in human, mouse for TAS2R39 (see all 6)
    OriGene ORF clones in mouse, rat for TAS2R39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAS2R39 (NM_176881)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAS2R39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R39
    Sirion Biotech Customized lentivirus for stable overexpression of TAS2R39 
                         Customized lentivirus expression plasmids for stable overexpression of TAS2R39 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R39
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R39
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R39
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R39

    Additional mRNA sequence: 

    BC100947.2 BC100948.2 BC114952.1 

    1 DOTS entry:

    DT.100702950 

    1 AceView cDNA sequence:

    NM_176881 

    GeneLoc Exon Structure


    Expression
    for TAS2R39 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAS2R39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCCTACC
    TAS2R39 Expression
    About this image


    See TAS2R39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAS2R39

    SOURCE GeneReport for Unigene cluster: Hs.553660

    UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

        SABiosciences Custom PCR Arrays for TAS2R39
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R39
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R39
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R39
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R39
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39

    Orthologs
    for TAS2R39 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TAS2R39 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tas2r1391 , 5 taste receptor, type 2, member 1391, 5 72.35(n)1
    57.53(a)1    		   6 (20.40 cM)5
    3531481  NM_181275.11  NP_851792.11 
     421409365 
    chicken
    (Gallus gallus)    		 Aves TAS2R76
    		 taste receptor type 2 member 7
    		 24(a)
    		 possible ortholog
    		 3(109476673-109477638)
    zebrafish
    (Danio rerio)    		 Actinopterygii tas2r200.26
    tas2r200.16
    		 taste receptor, type 2, member 200.1
    		 18(a)
    18(a)
    		 many ↔ many
    many ↔ many
    		 8(31629027-31630131)
    8(31631970-31633062)


    ENSEMBL Gene Tree for TAS2R39 (if available)
    TreeFam Gene Tree for TAS2R39 (if available)

    Paralogs
    for TAS2R39 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAS2R39 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R382  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R202  
    TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    18/28 SIMAP similar genes for TAS2R39 using alignment to 1 protein entry:     T2R39_HUMAN(see all similar genes):
    Hosa(Japanese)-T2R39    Hosa(Biaka)-T2R40    Hosa(Japanese)-T2R40    TAS2R40    Hosa(Adygei)-T2R4    Hosa(Biaka)-T2R13
    Hosa(Biaka)-T2R4    Hosa(Japanese)-T2R13    TAS2R13    TAS2R4    TAS2R1    TAS2R31
    TAS2R43    Hosa(Japanese)-T2R14    TAS2R10    TAS2R46    Hosa(Adygei)-T2R3    Hosa(Adygei)-T2R7

    TAS2R39 for paralogs           About GeneDecksing



    Genomic Variants
    for TAS2R39 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 SNPs in TAS2R39 are shown (see all 89)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1503558941,2
    		Cuntested1142881157(+) ACCTGA/G/TGGATT 2 G W mis10--------
    rs1842455221,2
    		--142878542(+) GAGCAA/TCTTCT 1 -- us2k10--------
    rs798567261,2
    		F--142878642(+) TTTCTC/TATCTG 1 -- us2k11Minor allele frequency- T:0.05EA 120
    rs1878688601,2
    		--142878677(+) CCTTTG/TTTCCC 1 -- us2k10--------
    rs755425121,2
    		C,F--142878686(+) CCCTCT/GGTCAC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1445025351,2
    		C--142878700(+) CCAGTA/GTTTCT 1 -- us2k10--------
    rs1149522251,2
    		F--142878911(+) TGTACT/CGCCTC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1484211451,2
    		--142878996(+) AGCCTC/TTGAAG 1 -- us2k10--------
    rs1417492511,2
    		C--142879058(+) TAGGGC/GAAAGC 1 -- us2k10--------
    rs1899489591,2
    		--142879233(+) AATTCA/GTAACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAS2R39 (142880512 - 142881528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TAS2R39:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676270CNV Deletion23128226
    esv2675537CNV Deletion23128226
    nsv465176CNV Loss19166990
    nsv465175CNV Loss19166990
    esv29078CNV Loss19812545
    dgv432n21CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R39
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R39

    Disorders / Diseases
    for TAS2R39 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TAS2R39 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAS2R39 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TAS2R39)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
    2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
    5. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
    6. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
    7. Soy isoflavones and other isoflavonoids activate the h uman bitter taste receptors hTAS2R14 and hTAS2R39. (PubMed id 21942422)1 Roland W.S....Smit G. (2011)
    8. Evaluation of the bitterness of green tea catechins b y a cell-based assay with the human bitter taste receptor hTAS2R39. (PubMed id 21272567)1 Narukawa M....Watanabe T. (2011)
    9. Human bitter taste receptors hTAS2R8 and hTAS2R39 wit h differential functions to recognize bitter peptides. (PubMed id 21670512)1 Ueno Y....Misaka T. (2011)
    10. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)

    External Searches for TAS2R39 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TAS2R39 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 259285 HGNC: 18886 AceView: TAS2R39 Ensembl:ENSG00000236398 euGenes: HUgn259285
    ECgene: TAS2R39 Kegg: 259285 H-InvDB: TAS2R39

    Other Databases showing TAS2R39 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAS2R39 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAS2R39 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TAS2R39 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TAS2R39 gene:
    Search GeneIP for patents involving TAS2R39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TAS2R39 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TAS2R39  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TAS2R39  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAS2R39  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R39   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAS2R39   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAS2R39   OriGene Custom Protein Services for TAS2R39  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAS2R39
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R39
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R39
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R39
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R39
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R39
     GenScript Custom Purified and Recombinant Proteins Services for TAS2R39 GenScript cDNA clones with any tag delivered in your preferred vector for TAS2R39
     GenScript Custom Assay Services for TAS2R39 GenScript Custom Superior Antibodies Services for TAS2R39
     GenScript Custom overexpressing Cell Line Services for TAS2R39 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TAS2R39 promoter
     Search Chromatin IP Primers for TAS2R39
     RT2 qPCR Primer Assay in human, mouse, rat TAS2R39
     Search GNC Networks for TAS2R39
     SABiosciences Custom PCR Arrays for TAS2R39
     Search Tocris compounds for TAS2R39 (T2R39)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TAS2R39 antibodies
     TAS2R39 lysates
     Antibodies for TAS2R39
     See all of Abcam's Antibodies, Kits and Proteins for TAS2R39
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TAS2R39
     Antibodies for TAS2R39
     ELISAs for TAS2R39
     CLIAs for TAS2R39
     Search LifeMap BioReagents cell lines for TAS2R39
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TAS2R39
     SwitchGear Promoter luciferase reporter plasmids for TAS2R39
     Search ThermoFisher Antibodies for TAS2R39
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R39
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TAS2R39
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAS2R39
    Customized:
     lentivirus for stable overexpression of TAS2R39
     lentivirus expression plasmids for stable overexpression of TAS2R39
     adenovirus for overexpression of TAS2R39
     LSBio Antibodies in human, mouse, rat for TAS2R39
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TAS2R39 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4