Aliases for TAS2R39 Gene
Aliases for TAS2R39 Gene
External Ids for TAS2R39 Gene
- HGNC: 18886
- Entrez Gene: 259285
- Ensembl: ENSG00000236398
- UniProtKB: P59534
Previous GeneCards Identifiers for TAS2R39 Gene
- GC00U991248
- GC07P142274
- GC07P142351
- GC07P142397
- GC07P142590
- GC07P142880
- GC07P137219
- GC07P143185
- GC07P143253
- GC07P143400
Summaries for TAS2R39 Gene
-
The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
GeneCards Summary for TAS2R39 Gene
TAS2R39 (Taste 2 Receptor Member 39) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R40.
UniProtKB/Swiss-Prot for TAS2R39 Gene
-
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R39 Gene
Genomics for TAS2R39 Gene
Regulatory Elements for TAS2R39 Gene
Enhancers for TAS2R39 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G143012 | 0.8 | ENCODE | 11.1 | -168.0 | -167966 | 4.9 | CTCF PKNOX1 RAD21 YY1 FOSL1 ZNF316 GATA2 SMC3 FOS NFE2 | OR9P1P OR6V1 TAS2R39 KEL TRBV11-2 OR9A2 |
| GH07G143042 | 0.8 | ENCODE | 10.9 | -140.4 | -140400 | 1.8 | FOXA2 ZNF48 RARA SCRT2 ETV6 CREM HMG20B JUNB CTCF SOX13 | TAS2R39 GSTK1 OR9P1P LOC105375544 |
| GH07G143120 | 0.6 | ENCODE | 11.3 | -62.6 | -62575 | 1.3 | PKNOX1 GATA3 JUND JUNB NR3C1 ATF2 | OR6V1 TAS2R39 OR9P1P KEL C7orf34 TRPV5 TMEM139 TCAF2 GSTK1 PIP |
| GH07G143098 | 0.6 | FANTOM5 | 11.1 | -84.5 | -84458 | 0.4 | JUND POLR2A MLLT1 EZH2 | OR6V1 OR9P1P TAS2R39 PIP OR6W1P |
| GH07G143244 | 1 | FANTOM5 Ensembl ENCODE | 6 | +61.9 | 61877 | 1.3 | MCM7 PRDM6 ZNF266 FOS | FAM131B TMEM139 CASP2 LOC105375545 RN7SL535P ZYX LOC100507507 OR9A2 TAS2R39 TRPV6 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TAS2R39 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TAS2R39 Gene
- Chromosome:
- 7
- Start:
- 143,183,419 bp from pter
- End:
- 143,184,435 bp from pter
- Size:
- 1,017 bases
- Orientation:
- Plus strand
Genomic View for TAS2R39 Gene
Genes around TAS2R39 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q34 by Ensembl
- 7q34 by Entrez Gene
- 7q34 by HGNC
TAS2R39 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAS2R39 Gene
Proteins for TAS2R39 Gene
-
Protein details for TAS2R39 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59534-T2R39_HUMAN
- Recommended name:
- Taste receptor type 2 member 39
- Protein Accession:
- P59534
- A4FUI7
- Q3ZCN6
- Q645W4
Protein attributes for TAS2R39 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 38626 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
- SequenceCaution:
-
- Sequence=AAM19321.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};
Post-translational modifications for TAS2R39 Gene
Other Protein References for TAS2R39 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Custom Antibody ServicesOriGene Antibodies for TAS2R39
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-
Abcam antibodies for TAS2R39
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- antibodies-online Antibodies for TAS2R39: See all 13
- GeneTex TAS2R39 antibody for TAS2R39
Protein Products
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No data available for DME Specific Peptides for TAS2R39 Gene
Domains & Families for TAS2R39 Gene
Gene Families for TAS2R39 Gene
- HGNC:
- IUPHAR :
Protein Domains for TAS2R39 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAS2R39 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P59534- Family:
-
- Belongs to the G-protein coupled receptor T2R family.
Function for TAS2R39 Gene
Molecular function for TAS2R39 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0033038 | bitter taste receptor activity | IDA | 20022913 |
Phenotypes for TAS2R39 Gene
- GenomeRNAi human phenotypes for TAS2R39:
Animal Model Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R39 Gene
Localization for TAS2R39 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAS2R39 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IC | 20022913 |
Pathways & Interactions for TAS2R39 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Taste transduction | ||
| 3 | Peptide ligand-binding receptors | ||
Pathways by source for TAS2R39 Gene
6 Reactome pathways for TAS2R39 Gene
1 KEGG pathway for TAS2R39 Gene
Interacting Proteins for TAS2R39 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 20022913 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0050896 | response to stimulus | IEA | -- |
| GO:0050909 | sensory perception of taste | IEA | -- |
No data available for SIGNOR curated interactions for TAS2R39 Gene
Drugs & Compounds for TAS2R39 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Acetaminophen | Approved | Pharma | Cyclooxygenase inhibitor; may be selective for COX-3 | 1026 | ||
| Chloramphenicol | Approved, Vet_approved | Pharma | 7 | |||
| chloroquine | Approved, Vet_approved | Pharma | Agonist | 149 | ||
| Colchicine | Approved | Pharma | Antagonist | Tubulin Inhibitor, Inhibitor of tubulin | 115 | |
| Diphenidol | Approved, Withdrawn | Pharma | 1 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (-)-Epicatechin gallate,Ecg,Epicatechin gallate |
|
|
|
|||
| (-)-Epicatechin,EC,Epicatechin |
|
|
|
|||
| (-)-epigallocatechin (EGC),epigallocatechin,Gallocatechol |
|
|
|
|||
| (+/-) Equol |
|
|
|
|||
| amarogentin |
|
21018-84-8 |
|
|
Transcripts for TAS2R39 Gene
mRNA/cDNA for TAS2R39 Gene
- (1) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TAS2R39
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAS2R39
- GenScript: Design CRISPR guide RNA sequences for TAS2R39
miRNA Products
- Search ViGene Biosciences for TAS2R39
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TAS2R39
- Browse OriGene Inhibitory RNA Products For TAS2R39
-
ViGene Biosciences ready-to-package AAV shRNAs for TAS2R39 gene
Clone Products
-
OriGene ORF clones in human for TAS2R39
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TAS2R39
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAS2R39
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for TAS2R39 Gene
NURSA nuclear receptor signaling pathways regulating expression of TAS2R39 Gene:
TAS2R39SOURCE GeneReport for Unigene cluster for TAS2R39 Gene:
Hs.553660mRNA Expression by UniProt/SwissProt for TAS2R39 Gene:
P59534-T2R39_HUMAN
Tissue specificity:
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Primer Products
-
OriGene qPCR primer pairs for TAS2R39
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R39 Gene
Orthologs for TAS2R39 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAS2R39 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TAS2R39 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TAS2R39 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tas2r139 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tas2r139 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | T2R39 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TAS2R7 35 |
|
OneToMany |
- Species where no ortholog for TAS2R39 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TAS2R39 Gene
Paralogs for TAS2R39 Gene
(28) SIMAP similar genes for TAS2R39 Gene using alignment to 1 proteins:
- Hosa(Japanese)-T2R39
- Hosa(Japanese)-T2R40
- Hosa(Biaka)-T2R40
- TAS2R40
- Hosa(Japanese)-T2R13
- Hosa(Biaka)-T2R4
- Hosa(Biaka)-T2R13
- Hosa(Adygei)-T2R4
- TAS2R13
- TAS2R4
- TAS2R1
- TAS2R43
- TAS2R31
- TAS2R46
- Hosa(Japanese)-T2R14
- TAS2R10
- TAS2R9
- TAS2R8
- TAS2R7
- Hosa(Biaka)-T2R7
- Hosa(Biaka)-T2R3
- Hosa(Adygei)-T2R7
- Hosa(Adygei)-T2R3
- TAS2R14
- TAS2R3
- TAS2R60
- TAS2R42
- TAS2R41
Variants for TAS2R39 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000175649 | -- | 143,184,610(+) | TCTTA(A/G)TGGTA | downstream-variant-500B | |
| rs1000249120 | -- | 143,184,242(+) | CAATG(C/G)AGTTG | reference, missense | |
| rs1000510219 | -- | 143,183,056(+) | GTGTG(C/T)ATGTG | upstream-variant-2KB | |
| rs1001951185 | -- | 143,183,765(+) | AATAA(C/G)TTTTA | reference, missense | |
| rs1002364583 | -- | 143,181,514(+) | ACCCT(A/G)CACTG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11660n54 | CNV | loss | 21841781 |
| dgv11661n54 | CNV | loss | 21841781 |
| dgv11663n54 | CNV | loss | 21841781 |
| dgv1977e212 | CNV | loss | 25503493 |
| dgv432n21 | CNV | loss | 19592680 |
| dgv6698n100 | CNV | loss | 25217958 |
| esv2675537 | CNV | deletion | 23128226 |
| esv2676270 | CNV | deletion | 23128226 |
| esv2764005 | CNV | loss | 21179565 |
| esv29078 | CNV | loss | 19812545 |
| esv3542554 | CNV | deletion | 23714750 |
| esv3615300 | CNV | loss | 21293372 |
| esv3615302 | CNV | loss | 21293372 |
| esv3615303 | CNV | loss | 21293372 |
| nsv465175 | CNV | loss | 19166990 |
| nsv465176 | CNV | loss | 19166990 |
| nsv608657 | CNV | loss | 21841781 |
| nsv608676 | CNV | loss | 21841781 |
| nsv608680 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.70;
32.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TAS2R39 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAS2R39
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R39 Gene
Disorders for TAS2R39 Gene
Relevant External Links for TAS2R39
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TAS2R39
No disorders were found for TAS2R39 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R39 Gene
Publications for TAS2R39 Gene
- Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
- The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 2 4 64
- Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4 64
Products for TAS2R39 Gene
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- Horizon Cell Lines for TAS2R39
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- VectorBuilder custom plasmid, inducible vectors for TAS2R39
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAS2R39
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TAS2R39 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
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