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TAS2R39 Gene(Protein Coding)

Taste 2 Receptor Member 39

GCID:
GC07P143185
GIFtS:
43
Genes Participants
UDN Logo

Aliases for TAS2R39 Gene

Aliases for TAS2R39 Gene

  • Taste 2 Receptor Member 39 2 3 5
  • Taste Receptor, Type 2, Member 39 2 3
  • Taste Receptor Type 2 Member 57 3 4
  • T2R39 3 4
  • T2R57 3 4

External Ids for TAS2R39 Gene

Previous GeneCards Identifiers for TAS2R39 Gene

  • GC00U991248
  • GC07P142274
  • GC07P142351
  • GC07P142397
  • GC07P142590
  • GC07P142880
  • GC07P137219

Summaries for TAS2R39 Gene

Entrez Gene Summary for TAS2R39 Gene

  • The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]

GeneCards Summary for TAS2R39 Gene

TAS2R39 (Taste 2 Receptor Member 39) is a Protein Coding gene. Among its related pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R39 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R39 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R39 Gene

Genomics for TAS2R39 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TAS2R39 Gene

Enhancers for TAS2R39 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R39 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TAS2R39 gene promoter:

Genomic Location for TAS2R39 Gene

Chromosome:
7
Start:
143,183,419 bp from pter
End:
143,184,435 bp from pter
Size:
1,017 bases
Orientation:
Plus strand

Genomic View for TAS2R39 Gene

Genes around TAS2R39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R39 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TAS2R39 Gene

Proteins for TAS2R39 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TAS2R39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59534-T2R39_HUMAN
    Recommended name:
    Taste receptor type 2 member 39
    Protein Accession:
    P59534
    Secondary Accessions:
    • A4FUI7
    • Q3ZCN6
    • Q645W4

    Protein attributes for TAS2R39 Gene

    Size:
    338 amino acids
    Molecular mass:
    38626 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
    SequenceCaution:
    • Sequence=AAM19321.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAS2R39 Gene

neXtProt entry for TAS2R39 Gene

Proteomics data for TAS2R39 Gene at MOPED

Post-translational modifications for TAS2R39 Gene

  • Glycosylation at Asn 185 and Asn 194
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R39 Gene

Domains & Families for TAS2R39 Gene

Gene Families for TAS2R39 Gene

HGNC:
IUPHAR :

Protein Domains for TAS2R39 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59534

UniProtKB/Swiss-Prot:

T2R39_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R39: view

Function for TAS2R39 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for TAS2R39 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Phenotypes for TAS2R39 Gene

GenomeRNAi human phenotypes for TAS2R39:
genes like me logo Genes that share phenotypes with TAS2R39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R39 Gene

Localization for TAS2R39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R39 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R39 Gene COMPARTMENTS Subcellular localization image for TAS2R39 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R39 Gene

Pathways & Interactions for TAS2R39 Gene

genes like me logo Genes that share pathways with TAS2R39: view

Pathways by source for TAS2R39 Gene

1 KEGG pathway for TAS2R39 Gene

Interacting Proteins for TAS2R39 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405095%0d%0a9606.ENSP00000330070%0d%0a9606.ENSP00000286758%0d%0a9606.ENSP00000355316%0d%0a9606.ENSP00000351671%0d%0a9606.ENSP00000397181%0d%0a
Selected Interacting proteins: ENSP00000405095 for TAS2R39 Gene via STRING

Gene Ontology (GO) - Biological Process for TAS2R39 Gene

None

No data available for SIGNOR curated interactions for TAS2R39 Gene

Drugs & Compounds for TAS2R39 Gene

Products:

  1. Drug

(9) Drugs for TAS2R39 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 902
Chloramphenicol Approved Pharma 6
chloroquine Approved Pharma Agonist 142
Chlorpheniramine Approved Pharma 66
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 105

(9) Additional Compounds for TAS2R39 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-Epicatechin gallate,Ecg,Epicatechin gallate
(-)-Epicatechin,EC,Epicatechin
(-)-epigallocatechin (EGC),epigallocatechin,Gallocatechol
(+/-) Equol
amarogentin
21018-84-8
genes like me logo Genes that share compounds with TAS2R39: view

Transcripts for TAS2R39 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TAS2R39 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R39 Gene

No ASD Table

Relevant External Links for TAS2R39 Gene

GeneLoc Exon Structure for
TAS2R39
ECgene alternative splicing isoforms for
TAS2R39

Expression for TAS2R39 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TAS2R39 Gene

mRNA expression in normal human tissues for TAS2R39 Gene
mRNA expression by GTEx for TAS2R39 Gene

SOURCE GeneReport for Unigene cluster for TAS2R39 Gene Hs.553660

mRNA Expression by UniProt/SwissProt for TAS2R39 Gene

P59534-T2R39_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R39 Gene

Orthologs for TAS2R39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TAS2R39 35
  • 78.11 (n)
  • 64.2 (a)
dog
(Canis familiaris)
 Mammalia TAS2R39 35
  • 83.6 (n)
  • 72.56 (a)
TAS2R39 36
  • 72 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tas2r139 35
  • 72.86 (n)
  • 57.77 (a)
Tas2r139 16
Tas2r139 36
  • 55 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia TAS2R39 35
  • 99.7 (n)
  • 99.41 (a)
TAS2R39 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tas2r139 35
  • 69.27 (n)
  • 55.05 (a)
oppossum
(Monodelphis domestica)
 Mammalia T2R39 36
  • 58 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TAS2R7 36
  • 23 (a)
 OneToMany
Species with no ortholog for TAS2R39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R39 Gene

ENSEMBL:
Gene Tree for TAS2R39 (if available)
TreeFam:
Gene Tree for TAS2R39 (if available)

Paralogs for TAS2R39 Gene

Paralogs for TAS2R39 Gene

(28) SIMAP similar genes for TAS2R39 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAS2R39: view

Variants for TAS2R39 Gene

Sequence variations from dbSNP and Humsavar for TAS2R39 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35474877 - 143,183,996(-) AGTTG(A/G)AGGAG reference, missense
rs34169190 - 143,184,007(-) TTTCT(C/T)AGTGG reference, missense
rs6964922 -- 143,182,716(+) GGGGA(C/T)ATAAA upstream-variant-2KB
rs75542512 -- 143,181,593(+) CCCTC(G/T)GTCAC upstream-variant-2KB
rs4103817 -- 143,184,192(+) CACAT(A/G)GGGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R39 Gene

Variant ID Type Subtype PubMed ID
nsv465175 CNV Loss 19166990
dgv432n21 CNV Loss 19592680
esv2675537 CNV Deletion 23128226
nsv465176 CNV Loss 19166990
esv2676270 CNV Deletion 23128226
esv29078 CNV Loss 19812545

Variation tolerance for TAS2R39 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAS2R39 Gene

Disorders for TAS2R39 Gene

Relevant External Links for TAS2R39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R39

No disorders were found for TAS2R39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R39 Gene

Publications for TAS2R39 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 67
  2. The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins. (PMID: 25273142) Yamazaki T. … Watanabe T. (Biosci. Biotechnol. Biochem. 2014) 3
  3. Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39. (PMID: 21272567) Narukawa M. … Watanabe T. (Biochem. Biophys. Res. Commun. 2011) 3
  4. Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides. (PMID: 21670512) Ueno Y. … Misaka T. (Biosci. Biotechnol. Biochem. 2011) 3
  5. Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. (PMID: 21942422) Roland W.S. … Smit G. (J. Agric. Food Chem. 2011) 3

Products for TAS2R39 Gene

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