TAS2R39 Gene

Aliases
for TAS2R39 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC00U991248 GC07P142274 GC07P142351 GC07P142397 GC07P142590 GC07P137219

Summaries
for TAS2R39 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TAS2R39 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000007.13  NC_018918.2  NT_007933.16  

SwitchGear Promoter luciferase reporter plasmid: TAS2R39 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R39

TAS2R39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142880:  view genomic region     (about GC identifiers)

Proteins
for TAS2R39 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for TAS2R39:

2GFZ (3D)    

Explore the universe of human proteins at neXtProt for TAS2R39: NX_P59534

Explore proteomics data for TAS2R39 at MOPED

Post-translational modifications: 

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Domains /
Families
for TAS2R39 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P59534

Find genes that share domains with TAS2R39           About GenesLikeMe

Function
for TAS2R39 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

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Gene Editing Products:

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39

Localization
for TAS2R39 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	3

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for TAS2R39 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for TAS2R39 About     See pathways by source

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	SuperPath	Contained pathways About
1	Taste transduction	Class C/3 (Metabotropic glutamate/pheromone receptors) 0.45 Taste transduction 0.45
2	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90
3	Peptide ligand-binding receptors	GPCR ligand binding 0.71 G alpha (i) signalling events 0.44

2 Reactome Pathways for TAS2R39

	Class C/3 (Metabotropic glutamate/pheromone receptors)
	G alpha (i) signalling events

1 Kegg Pathway  (Kegg details for TAS2R39)

Taste transduction

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for TAS2R39 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TAS2R39 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TAS2R39 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TAS2R39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTGCCTACC

About this image

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39

Orthologs
for TAS2R39 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TAS2R39 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TAS2R39 gene

TAS2R41²  TAS2R5²  TAS2R46²  TAS2R16²  TAS2R3²  TAS2R43²  TAS2R14²  TAS2R38²  

TAS2R42²  TAS2R9²  TAS2R4²  TAS2R30²  TAS2R1²  TAS2R19²  TAS2R7²  TAS2R20²  

TAS2R8²  TAS2R10²  TAS2R50²  TAS2R13²  TAS2R40²  TAS2R60²  TAS2R31²  

Selected SIMAP similar genes for TAS2R39 using alignment to 1 protein entry:     T2R39_HUMAN(see all similar genes):

Hosa(Japanese)-T2R39    Hosa(Biaka)-T2R40    Hosa(Japanese)-T2R40    TAS2R40    Hosa(Adygei)-T2R4    Hosa(Biaka)-T2R13

Hosa(Biaka)-T2R4    Hosa(Japanese)-T2R13    TAS2R13    TAS2R4    TAS2R1    TAS2R31

TAS2R43    Hosa(Japanese)-T2R14    TAS2R10    TAS2R46    Hosa(Adygei)-T2R3    Hosa(Adygei)-T2R7

Find genes that share paralogs with TAS2R39           About GenesLikeMe

Genomic Variants
for TAS2R39 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TAS2R39 (see all 89)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1503558941,2	C	untested1	142881157(+)	ACCTGA/G/TGGATT	2	G W	mis1		0	--	--	--	--
rs1842455221,2		--	142878542(+)	GAGCAA/TCTTCT	1	--	us2k1		0	--	--	--	--
rs798567261,2	F	--	142878642(+)	TTTCTC/TATCTG	1	--	us2k1		1		EA	120
rs1878688601,2		--	142878677(+)	CCTTTG/TTTCCC	1	--	us2k1		0	--	--	--	--
rs755425121,2	C,F	--	142878686(+)	CCCTCT/GGTCAC	1	--	us2k1		1		WA	118
rs1445025351,2	C	--	142878700(+)	CCAGTA/GTTTCT	1	--	us2k1		0	--	--	--	--
rs1149522251,2	F	--	142878911(+)	TGTACT/CGCCTC	1	--	us2k1		1		WA	118
rs1484211451,2		--	142878996(+)	AGCCTC/TTGAAG	1	--	us2k1		0	--	--	--	--
rs1417492511,2	C	--	142879058(+)	TAGGGC/GAAAGC	1	--	us2k1		0	--	--	--	--
rs1899489591,2		--	142879233(+)	AATTCA/GTAACA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TAS2R39 (142880512 - 142881528 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for TAS2R39:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2676270	CNV	Deletion	23128226
esv2675537	CNV	Deletion	23128226
nsv465176	CNV	Loss	19166990
nsv465175	CNV	Loss	19166990
esv29078	CNV	Loss	19812545
dgv432n21	CNV	Loss	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TAS2R39

DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R39

Disorders / Diseases
for TAS2R39 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TAS2R39 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)^{1, 2, 3} Bufe B.... Meyerhof W. (Nat. Genet. 2002)
2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)^{1, 2} Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)^{1, 2} Zhang Y.... Ryba N.J. (Cell 2003)
5. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)^{1, 2} Margolskee R.F. (J. Biol. Chem. 2002)
6. Receptors for bitter and sweet taste. (PubMed id 12139982)^{1, 2} Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)
7. Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. (PubMed id 21942422)¹ Roland W.S....Smit G. (J. Agric. Food Chem. 2011)
8. Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39. (PubMed id 21272567)¹ Narukawa M....Watanabe T. (Biochem. Biophys. Res. Commun. 2011)
9. Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides. (PubMed id 21670512)¹ Ueno Y....Misaka T. (Biosci. Biotechnol. Biochem. 2011)
10. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)¹ Go Y.... Takahata N. (Genetics 2005)

External Searches for TAS2R39 gene

Genome Databases showing TAS2R39 gene

Other Databases showing TAS2R39 gene

Specialized Databases showing TAS2R39 gene

Products
for TAS2R39 gene

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Advanced Cell Diagnostics, Animal models from genOway)
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