TAS2R39 Gene
protein-coding GIFtS: 47
GCID: GC07P142880
|
|
taste receptor, type 2, member 39
| |
Aliases
for TAS2R39 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 2, Member 391 2 | | Taste Receptor Type 2 Member 572 3 | | T2R392 3 | | T2R572 3 | | Taste Receptor Type 2 Member 392 |
Export aliases for TAS2R39 gene to outside databasesPrevious GC identifers: GC00U991248 GC07P142274 GC07P142351 GC07P142397 GC07P142590 GC07P137219 |
Summaries
for TAS2R39 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)
Gene Wiki entry for TAS2R39
|
Genomic Views
for TAS2R39 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R39 gene promoter:
AML1a HTF FOXD3 FOXL1 POU2F1 FOXO4 POU2F1a FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R39
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R39 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34TAS2R39 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P142880: view genomic region
(about GC identifiers)
Start:
|
142,880,512 bp from pter |
End:
|
142,881,528 bp from pter |
Size:
|
1,017 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 142,282,647-142,283,663 |
|
Proteins
for TAS2R39 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534 (See
protein sequence)Recommended Name: Taste receptor type 2 member 39 Size: 338 amino acids; 38626 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells candiscriminate among bitter stimuli
Sequence caution: Sequence=AAM19321.1; Type=Frameshift; Positions=323;
1 PDB 3D structure from  and Proteopedia  for TAS2R39:2GFZ (3D)
Secondary accessions: A4FUI7 Q3ZCN6 Q645W4Explore the universe of human proteins at neXtProt for TAS2R39: NX_P59534
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59534
TAS2R39 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_795362.2
ENSEMBL proteins: ENSP00000405095
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TAS2R39 for ontologies About GeneDecksing
TAS2R39 Antibody Products:
Assay Products for TAS2R39: |
Protein
Domains /
Families
for TAS2R39 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R39 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P59534ProtoNet protein and cluster: P59534 1 Blocks protein family: IPB001400 Somatotropin hormone
UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534Similarity: Belongs to the G-protein coupled receptor T2R family |
Function
for TAS2R39 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R39 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R39
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAS2R39 (NM_176881) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
TAS2R39 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TAS2R39:
|
Pathways & Interactions
for TAS2R39 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Taste transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for TAS2R39):
TAS2R39 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R39
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TAS2R39 (ENSP000004050954) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050909 | sensory perception of taste |
IEA | -- |
TAS2R39 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R39 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS2R39
10/18 BitterDB Bitter Compounds for TAS2R39 (see all 18)
About this table
Search CenterWatch for drugs/clinical trials and news about TAS2R39 / T2R39
|
Transcripts
for TAS2R39 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS2R39 gene: NM_176881.2 Unigene Cluster for TAS2R39: Taste receptor, type 2, member 39 Hs.553660 Unigene Representative Sequence: NM_1768811 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000446620(uc011ksw.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R39 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R39
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS2R39 (NM_176881) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R39 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R39 |
Additional cDNA sequence: BC100947.2 BC100948.2 BC114952.1 1 DOTS entry: DT.100702950 1 AceView cDNA sequence: NM_176881
GeneLoc Exon Structure
|
Expression
for TAS2R39 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS2R39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCCTACC
About this image
See TAS2R39 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS2R39
SOURCE GeneReport for Unigene cluster: Hs.553660
UniProtKB/Swiss-Prot: T2R39_HUMAN, P59534Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positivecells
SABiosciences Custom PCR Arrays for TAS2R39
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R39
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R39 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R39 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R39 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39 |
Orthologs
for TAS2R39 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAS2R39 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
--Q2AB81_CHICK6 |
Taste receptor type 2 |
37(a)23(a) |
1 ↔ manypossible ortholog |
1(80959628-80960488) 3(112675246-112676211) |
ENSEMBL Gene Tree for TAS2R39 (if available)
TreeFam Gene Tree for TAS2R39 (if available) |
Paralogs
for TAS2R39 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAS2R39 gene
- TAS2R52 TAS2R412 TAS2R462 TAS2R162 TAS2R32 TAS2R142 TAS2R432 TAS2R382
- TAS2R422 TAS2R92 TAS2R42 TAS2R302 TAS2R12 TAS2R192 TAS2R72 TAS2R202
- TAS2R82 TAS2R132 TAS2R402 TAS2R102 TAS2R502 TAS2R602 TAS2R312
18/28 SIMAP similar genes for TAS2R39 using alignment to 1 protein entry: T2R39_HUMAN(see all similar genes):Hosa(Japanese)-T2R39 Hosa(Biaka)-T2R40 Hosa(Japanese)-T2R40 TAS2R40 Hosa(Adygei)-T2R4 Hosa(Biaka)-T2R13
Hosa(Biaka)-T2R4 Hosa(Japanese)-T2R13 TAS2R13 TAS2R4 TAS2R1 TAS2R31
TAS2R43 Hosa(Japanese)-T2R14 TAS2R10 TAS2R46 Hosa(Adygei)-T2R3 Hosa(Adygei)-T2R7
TAS2R39 for paralogs About GeneDecksing
|
Genomic Variants
for TAS2R39 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAS2R39 (142880512 - 142881528 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TAS2R39
3 CNVs: 94910 52137 64972 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R39 |
|
Disorders
/ Diseases
for TAS2R39 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TAS2R39 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS2R39 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TAS2R39) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Soy isoflavones and other isoflavonoids activate the h uman bitter taste receptors hTAS2R14 and hTAS2R39. (PubMed id 21942422)1 Roland W.S....Smit G. (2011)
- Evaluation of the bitterness of green tea catechins b y a cell-based assay with the human bitter taste receptor hTAS2R39. (PubMed id 21272567)1 Narukawa M....Watanabe T. (2011)
- Human bitter taste receptors hTAS2R8 and hTAS2R39 wit h differential functions to recognize bitter peptides. (PubMed id 21670512)1 Ueno Y....Misaka T. (2011)
- Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
|
External Searches for TAS2R39 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS2R39 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R39 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R39 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS2R39 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAS2R39 gene:
Search GeneIP for patents involving TAS2R39
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R39 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
 |
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 | | | TAS2R39 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R39 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R39 |
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