Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R38 Gene

protein-coding   GIFtS: 54
GCID: GC07M141672

Taste Receptor, Type 2, Member 38

(Previous name: phenylthiocarbamide tasting)
(Previous symbol: PTC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 381 2     T2R382 3
PTC1 2 3 5     PTC Bitter Taste Receptor2 3
T2R612 3 5     Phenylthiocarbamide Tasting1
Taste Receptor Type 2 Member 612 3     Taste Receptor Type 2 Member 382

External Ids:    HGNC: 95841   Entrez Gene: 57262   Ensembl: ENSG000002571387   OMIM: 6077515   UniProtKB: P595333   

Export aliases for TAS2R38 gene to outside databases

Previous GC identifers: GC00U991247 GC07M141002 GC07M141079 GC07M141125 GC07M141318 GC07M135968


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R38 Gene:
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste
glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds
phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and
have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been
identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa.
These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V,
and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster
variant). (provided by RefSeq, Oct 2009)

GeneCards Summary for TAS2R38 Gene: 
TAS2R38 (taste receptor, type 2, member 38) is a protein-coding gene. Diseases associated with TAS2R38 include motion sickness, and phenylthiocarbamide tasting, and among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R38 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R38 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TAS2R38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R38 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141672:  view genomic region     (about GC identifiers)

Start:
141,672,431 bp from pter      End:
141,673,573 bp from pter
Size:
1,143 bases      Orientation:
minus strand

2 alternative locations:
Chr7-,CRA_TCAG 141,010,626-141,011,768      Chr7-,NW_003571040 114,582-115,724     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533 (See protein sequence)
Recommended Name: Taste receptor type 2 member 38  
Size: 333 amino acids; 37892 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: A4D1U6 P59552 Q2M3E8 Q645W3 Q86UK3

Explore the universe of human proteins at neXtProt for TAS2R38: NX_P59533

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59533

  • TAS2R38 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_789787.4  
    ENSEMBL proteins: 
     ENSP00000448219  
    Reactome Protein details: P59533
    Human Recombinant Protein Products for TAS2R38: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TAS2R38
    OriGene Protein Over-expression Lysate for TAS2R38
    OriGene MassSpec for TAS2R38 
    OriGene Custom Protein Services for TAS2R38
    GenScript Custom Purified and Recombinant Proteins Services for TAS2R38
    Novus Biologicals TAS2R38 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAS2R38 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    TAS2R38 for ontologies           About GeneDecksing



    TAS2R38 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TAS2R38
    GenScript Custom Superior Antibodies Services for TAS2R38
    Novus Biologicals TAS2R38 Antibody
    Abcam antibodies for TAS2R38
    Cloud-Clone Corp. Antibodies for TAS2R38 
    ThermoFisher Antibodies for TAS2R38
    LSBio Antibodies in human, mouse, rat for TAS2R38 

    Assay Products for TAS2R38: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAS2R38
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAS2R38
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAS2R38 
    Cloud-Clone Corp. CLIAs for TAS2R38


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R38 
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59533

    ProtoNet protein and cluster: P59533

    UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
    Similarity: Belongs to the G-protein coupled receptor T2R family


    TAS2R38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R38_HUMAN, P59533
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    TAS2R38 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAS2R38 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAS2R38

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAS2R38 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAS2R38 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAS2R38
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TAS2R38
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAS2R38
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R38

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAS2R38
    Sirion Biotech Customized adenovirus for overexpression of TAS2R38

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TAS2R38 (see all 6)
    OriGene ORF clones in mouse, rat for TAS2R38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAS2R38 (NM_176817)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAS2R38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R38
    Sirion Biotech Customized lentivirus for stable overexpression of TAS2R38 
                         Customized lentivirus expression plasmids for stable overexpression of TAS2R38 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAS2R38
    Search LifeMap BioReagents cell lines for TAS2R38
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R38


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAS2R38 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class C/3 (Metabotropic glutamate/pheromone receptors)
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R38
        Bitter Taste Signaling

    5/6        Reactome Pathways for TAS2R38 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for TAS2R38):
        Taste transduction


    TAS2R38 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAS2R38

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050909sensory perception of taste IEA--

    TAS2R38 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAS2R38 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAS2R38 (T2R38)

    10/21 BitterDB Bitter Compounds for TAS2R38 (see all 21) About this table
    CompoundSMILES CAS #
    6-Methyl-2-thiouracilCc1cc(O)nc(S)n1--
    acetylthioureaCC(=O)NC(=S)N--
    allyl isothiocyanateC=CCN=C=S--
    Caprolactam O=C1CCCCCN1--
    ChlorpheniramineCN(C)CCC(c1ccc(Cl)cc1)c2ccccn2--
    dimethylthioformamideCN(C)C=S--
    diphenidolOC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3--
    diphenylthiourea,sulfocarbanilide,sym-Diphenylthiourea,thiocarbanilideS=C(Nc1ccccc1)Nc2ccccc2102-08-9
    Ethylene Thiourea,N,N-ethylene thioureaS=C1NCCN1--
    Ethylpyrazine CCc1cnccn1--


    2 Novoseek inferred chemical compound relationships for TAS2R38 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phenylthiocarbamide 96.2 9 17118801 (2), 17250611 (2), 15466815 (1), 18209019 (1) (see all 6)
    propylthiouracil 87.6 19 18719631 (3), 15547448 (3), 18209019 (3), 17250611 (2) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TAS2R38 / T2R38

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAS2R38 gene: 
    NM_176817.4  

    Unigene Cluster for TAS2R38:

    Taste receptor, type 2, member 38
    Hs.647085
    Unigene Representative Sequence: NM_176817
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000547270(uc003vwx.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAS2R38
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TAS2R38
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAS2R38
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R38
    Clone
    Products:
         
    OriGene clones in human, mouse for TAS2R38 (see all 6)
    OriGene ORF clones in mouse, rat for TAS2R38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAS2R38 (NM_176817)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAS2R38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R38
    Sirion Biotech Customized lentivirus for stable overexpression of TAS2R38 
                         Customized lentivirus expression plasmids for stable overexpression of TAS2R38 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TAS2R38
    OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R38
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R38
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R38
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R38

    Additional mRNA sequence: 

    BC104933.1 BC104937.1 

    1 DOTS entry:

    DT.100701086 

    1 AceView cDNA sequence:

    NM_176817 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAS2R38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGAGCTC
    TAS2R38 Expression
    About this image


    Genevestigator expression for TAS2R38

    SOURCE GeneReport for Unigene cluster: Hs.647085

    UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

        SABiosciences Custom PCR Arrays for TAS2R38
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TAS2R38
    OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R38
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R38
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R38
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R38
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TAS2R38 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1381 , 5 taste receptor, type 2, member 1381, 5 76.54(n)1
    65.56(a)1
      6 (18.82 cM)5
    3875131  NM_001001451.11  NP_001001451.11 
     406123155 
    chicken
    (Gallus gallus)
    Aves TAS2R76
    taste receptor type 2 member 7
    21(a)
    possible ortholog
    3(109476673-109477638)
    zebrafish
    (Danio rerio)
    Actinopterygii tas2r200.26
    tas2r200.16
    taste receptor, type 2, member 200.1
    16(a)
    14(a)
    many ↔ many
    many ↔ many
    8(31629027-31630131)
    8(31631970-31633062)


    ENSEMBL Gene Tree for TAS2R38 (if available)
    TreeFam Gene Tree for TAS2R38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAS2R38 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R202  
    TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    18/41 SIMAP similar genes for TAS2R38 using alignment to 2 protein entries:     T2R38_HUMAN (see all proteins) (see all similar genes):
    Hosa(Adygei)-T2R38    Hosa(Biaka)-T2R38    Hosa(Japanese)-T2R38    PTC    TAS2R9    Hosa(Adygei)-T2R49
    Hosa(Biaka)-T2R49    Hosa(Biaka)-T2R55    Hosa(Japanese)-T2R49    TAS2R20    TAS2R42    TAS2R49
    TAS2R7    TAS2R8    Hosa(Adygei)-T2R3    Hosa(Adygei)-T2R55    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R13

    TAS2R38 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
    Polymorphism: Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting)
    [MIM:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related
    substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For
    some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless.
    Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding
    SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity


    10/95 SNPs in TAS2R38 are shown (see all 95)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17268661,2,4
    C,F,O,A,Hdrug-response1145034015(-) CTGTGC/TTGCCT 2 A V mis132Minor allele frequency- T:0.45MN EA NA NS CSA WA EU 9033
    rs7135981,2,4
    C,F,A,Hdrug-response1145034655(-) GGCAGG/CCACTG 2 /P /A mis128Minor allele frequency- C:0.45NA EA NS WA CSA EU 7643
    rs102469391,2,4
    C,F,A,Hpathogenic1145033914(+) CAGGAT/CGGCTG 2 /I /V mis131Minor allele frequency- C:0.49NA NS EA WA CSA EU 8722
    rs737402181,2
    C,F--145033368(+) TAGTAG/ATGAAT 1 -- ds50012Minor allele frequency- A:0.04WA 120
    rs2021385051,2
    --145033617(+) AGTGC-/TTAA  
            
    TTATT
    1 -- ds50010--------
    rs1809338601,2
    --145033680(+) TTGTGC/TTTTAT 1 -- ds50010--------
    rs1379020351,2
    C--145033811(+) GTGTCC/TGGGAA 2 Q R mis10--------
    rs2000551111,2
    C--145033978(+) TTGTCA/GCGCCA 2 R syn10--------
    rs1390850461,2
    C,F--145033979(+) TGTCGC/TGCCAC 2 H R mis11Minor allele frequency- T:0.00NA 4552
    rs1142888461,2
    C,F--145033980(+) GTCGCG/ACCACA 2 /R /C mis13Minor allele frequency- A:0.01WA NA EU 5991

    HapMap Linkage Disequilibrium report for TAS2R38 (141672431 - 141673573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TAS2R38:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831161CNV Loss17160897
    nsv524927CNV Gain19592680


    Human Gene Mutation Database (HGMD): TAS2R38
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R38
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607751   
    OMIM disorders: 171200  
    9 diseases for TAS2R38:    About MalaCards
    motion sickness    phenylthiocarbamide tasting    dental caries    nicotine dependence
    thyroid cancer    coronary heart disease    alcoholism    thyroiditis
    neuronitis


    TAS2R38 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAS2R38
    Human Genome Epidemiology (HuGE) Navigator: TAS2R38 (24 documents)

    Export disorders for TAS2R38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAS2R38 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with TAS2R38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. (PubMed id 12595690)1, 2, 4 Kim U.-K.... Drayna D.T. (2003)
    2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (2002)
    3. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. (PubMed id 17250611)1, 4, 9 Wang J.C....Goate A.M. (2007)
    4. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. (PubMed id 19782709)1, 4, 9 Dotson C.D....Steinle N.I. (2009)
    5. Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. (PubMed id 18719631)1, 4, 9 Tepper B.J....Gasparini P. (2008)
    6. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. (PubMed id 15466815)1, 4, 9 Prodi D.A....Angius A. (2004)
    7. The perception of quinine taste intensity is associat ed with common genetic variants in a bitter receptor cluster on chromosome 12. (PubMed id 20675712)1, 4 Reed D.R....Wright M.J. (2010)
    8. Sex differences in the effects of inherited bitter th iourea sensitivity on body weight in 4-6-year-old children. (PubMed id 19779476)1, 4 Keller K.L....Kissileff H.R. (2010)
    9. Taste genes associated with dental caries. (PubMed id 20858777)1, 4 Wendell S....Marazita M.L. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5726 HGNC: 9584 AceView: TAS2R38 Ensembl:ENSG00000257138 euGenes: HUgn5726
    ECgene: TAS2R38 Kegg: 5726 H-InvDB: TAS2R38

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAS2R38 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAS2R38 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt119.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAS2R38 gene:
    Search GeneIP for patents involving TAS2R38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TAS2R38  
     OriGene qPCR primer pairs and template standards for TAS2R38   OriGene Protein Over-expression Lysate for TAS2R38  
     OriGene MassSpec something-or-other for TAS2R38   OriGene clones in human, mouse for TAS2R38  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R38   OriGene Purified Protein for TAS2R38  
     OriGene ORF clones in mouse, rat for TAS2R38   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAS2R38   OriGene Custom Protein Services for TAS2R38  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAS2R38
     QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R38
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R38
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R38
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R38
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R38
     GenScript Custom Purified and Recombinant Proteins Services for TAS2R38 GenScript cDNA clones with any tag delivered in your preferred vector for TAS2R38
     GenScript Custom Assay Services for TAS2R38 GenScript Custom Superior Antibodies Services for TAS2R38
     GenScript Custom overexpressing Cell Line Services for TAS2R38 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TAS2R38 promoter
     Search Chromatin IP Primers for TAS2R38
     RT2 qPCR Primer Assay in human, mouse, rat TAS2R38
     GNC Network for TAS2R38
     SABiosciences PCR Arrays including human, mouse, rat TAS2R38
     Search Tocris compounds for TAS2R38 (T2R38)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TAS2R38 antibodies
     TAS2R38 lysates
     Antibodies for TAS2R38
     See all of Abcam's Antibodies, Kits and Proteins for TAS2R38
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TAS2R38
     Antibodies for TAS2R38
     ELISAs for TAS2R38
     CLIAs for TAS2R38
     Search LifeMap BioReagents cell lines for TAS2R38
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R38
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TAS2R38
     SwitchGear Promoter luciferase reporter plasmids for TAS2R38
     ThermoFisher Antibodies for TAS2R38
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R38
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TAS2R38
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAS2R38
    Customized:
     lentivirus for stable overexpression of TAS2R38
     lentivirus expression plasmids for stable overexpression of TAS2R38
     adenovirus for overexpression of TAS2R38
     LSBio Antibodies in human, mouse, rat for TAS2R38
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAS2R38 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4