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TAS2R38 Gene

protein-coding   GIFtS: 53
GCID: GC07M141672

Taste Receptor, Type 2, Member 38

(Previous name: phenylthiocarbamide tasting)
(Previous symbol: PTC)
  See TAS2R38-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 2, Member 381 2     T2R382 3
PTC1 2 3 5     PTC Bitter Taste Receptor2 3
T2R612 3 5     Phenylthiocarbamide Tasting1
Taste Receptor Type 2 Member 612 3     Taste Receptor Type 2 Member 382

External Ids:    HGNC: 95841   Entrez Gene: 57262   Ensembl: ENSG000002571387   OMIM: 6077515   UniProtKB: P595333   

Export aliases for TAS2R38 gene to outside databases

Previous GC identifers: GC00U991247 GC07M141002 GC07M141079 GC07M141125 GC07M141318 GC07M135968


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAS2R38 Gene:
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste
glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds
phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and
have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been
identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa.
These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V,
and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster
variant). (provided by RefSeq, Oct 2009)

GeneCards Summary for TAS2R38 Gene:
TAS2R38 (taste receptor, type 2, member 38) is a protein-coding gene. Diseases associated with TAS2R38 include dental caries, and nicotine dependence. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R38 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R38 promoter sequence
   Search Chromatin IP Primers for TAS2R38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TAS2R38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R38 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141672:  view genomic region     (about GC identifiers)

Start:
141,672,431 bp from pter      End:
141,673,573 bp from pter
Size:
1,143 bases      Orientation:
minus strand

2 alternative locations:
Chr7-,CRA_TCAG 141,010,626-141,011,768      Chr7-,NW_003571040 114,582-115,724     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533 (See protein sequence)
Recommended Name: Taste receptor type 2 member 38  
Size: 333 amino acids; 37892 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: A4D1U6 P59552 Q2M3E8 Q645W3 Q86UK3

Explore the universe of human proteins at neXtProt for TAS2R38: NX_P59533

Explore proteomics data for TAS2R38 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn89, Asn178

  • See TAS2R38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_789787.4  
    ENSEMBL proteins: 
     ENSP00000448219  
    Reactome Protein details: P59533

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R38
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59533

    ProtoNet protein and cluster: P59533

    UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
    Similarity: Belongs to the G-protein coupled receptor T2R family


    Find genes that share domains with TAS2R38           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R38_HUMAN, P59533
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with TAS2R38           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2R38_HUMAN, P59533: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TAS2R38           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS2R38 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44


    Find genes that share SuperPaths with TAS2R38           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TAS2R38
        Bitter Taste Signaling

    2 Reactome Pathways for TAS2R38
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R38):
        Taste transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R38
    Interactions:

        GeneGlobe Interaction Network for TAS2R38

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050909sensory perception of taste IEA--

    Find genes that share ontologies with TAS2R38           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS2R38 (T2R38)

    Selected BitterDB Bitter Compounds for TAS2R38 (see all 21)    About this table
    CompoundSMILES CAS #
    6-Methyl-2-thiouracilCc1cc(O)nc(S)n1--
    acetylthioureaCC(=O)NC(=S)N--
    allyl isothiocyanateC=CCN=C=S--
    Caprolactam O=C1CCCCCN1--
    ChlorpheniramineCN(C)CCC(c1ccc(Cl)cc1)c2ccccn2--
    dimethylthioformamideCN(C)C=S--
    diphenidolOC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3--
    diphenylthiourea,sulfocarbanilide,sym-Diphenylthiourea,thiocarbanilideS=C(Nc1ccccc1)Nc2ccccc2102-08-9
    Ethylene Thiourea,N,N-ethylene thioureaS=C1NCCN1--
    Ethylpyrazine CCc1cnccn1--


    2 Novoseek inferred chemical compound relationships for TAS2R38 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phenylthiocarbamide 96.2 9 17118801 (2), 17250611 (2), 15466815 (1), 18209019 (1) (see all 6)
    propylthiouracil 87.6 19 18719631 (3), 15547448 (3), 18209019 (3), 17250611 (2) (see all 5)



    Find genes that share compounds with TAS2R38           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAS2R38 gene: 
    NM_176817.4  

    Unigene Cluster for TAS2R38:

    Taste receptor, type 2, member 38
    Hs.647085
    Unigene Representative Sequence: NM_176817
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000547270(uc003vwx.1)
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      QuantiFast Probe-based Assays in human, mouse, rat TAS2R38

    Additional mRNA sequence: 

    BC104933.1 BC104937.1 

    1 DOTS entry:

    DT.100701086 

    1 AceView cDNA sequence:

    NM_176817 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: AAATGAGCTC

    TAS2R38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS2R38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647085

    UniProtKB/Swiss-Prot: T2R38_HUMAN, P59533
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAS2R38 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1381 , 5 taste receptor, type 2, member 1381, 5 76.54(n)1
    65.56(a)1
      6 (18.82 cM)5
    3875131  NM_001001451.11  NP_001001451.11 
     406123155 
    chicken
    (Gallus gallus)
    Aves TAS2R76
    Gallus gallus taste receptor, type 2, member 7 (TA...
    21(a)
    1 → many
    3(109476673-109477638)


    ENSEMBL Gene Tree for TAS2R38 (if available)
    TreeFam Gene Tree for TAS2R38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS2R38 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R202  
    TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    Selected SIMAP similar genes for TAS2R38 using alignment to 2 protein entries:     T2R38_HUMAN (see all proteins) (see all similar genes):
    Hosa(Adygei)-T2R38    Hosa(Biaka)-T2R38    Hosa(Japanese)-T2R38    PTC    TAS2R9    Hosa(Adygei)-T2R49
    Hosa(Biaka)-T2R49    Hosa(Biaka)-T2R55    Hosa(Japanese)-T2R49    TAS2R20    TAS2R42    TAS2R49
    TAS2R7    TAS2R8    Hosa(Adygei)-T2R3    Hosa(Adygei)-T2R55    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R13

    Find genes that share paralogs with TAS2R38           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    T2R38_HUMAN, P59533: Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting)
    [MIM:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related
    substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For
    some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless.
    Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding
    SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity


    Selected SNPs for TAS2R38 (see all 95)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17268661,2,,4
    C,F,O,A,Hdrug-response1145034015(-) CTGTGC/TTGCCT 2 A V mis132Minor allele frequency- T:0.45MN EA NA NS CSA WA EU 9033
    rs7135981,2,,4
    C,F,A,Hdrug-response1145034655(-) GGCAGG/CCACTG 2 /P /A mis128Minor allele frequency- C:0.45NA EA NS WA CSA EU 7643
    rs102469391,2,,4
    C,F,A,Hpathogenic1145033914(+) CAGGAT/CGGCTG 2 /I /V mis131Minor allele frequency- C:0.49NA NS EA WA CSA EU 8722
    rs737402181,2
    C,F--145033368(+) TAGTAG/ATGAAT 1 -- ds50012Minor allele frequency- A:0.04WA 120
    rs2021385051,2
    --145033617(+) AGTGC-/TTAA  
            
    TTATT
    1 -- ds50010--------
    rs1809338601,2
    --145033680(+) TTGTGC/TTTTAT 1 -- ds50010--------
    rs1379020351,2
    C--145033811(+) GTGTCC/TGGGAA 2 Q R mis10--------
    rs2000551111,2
    C--145033978(+) TTGTCA/GCGCCA 2 R syn10--------
    rs1390850461,2
    C,F--145033979(+) TGTCGC/TGCCAC 2 H R mis11Minor allele frequency- T:0.00NA 4552
    rs1142888461,2
    C,F--145033980(+) GTCGCG/ACCACA 2 /R /C mis13Minor allele frequency- A:0.01WA NA EU 5991

    HapMap Linkage Disequilibrium report for TAS2R38 (141672431 - 141673573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TAS2R38:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831161CNV Loss17160897
    nsv524927CNV Gain19592680

    Human Gene Mutation Database (HGMD): TAS2R38
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R38
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607751   
    OMIM disorders: 171200  
    2 diseases for TAS2R38:    
    About MalaCards
    dental caries    nicotine dependence


    Find genes that share disorders with TAS2R38           About GenesLikeMe

    Genetic Association Database (GAD): TAS2R38
    Human Genome Epidemiology (HuGE) Navigator: TAS2R38 (24 documents)

    Export disorders for TAS2R38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS2R38 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with TAS2R38)
        Utopia: connect your pdf to the dynamic
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    1. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. (PubMed id 12595690)1, 2, 4 Kim U.-K.... Drayna D.T. (Science 2003)
    2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (Cytogenet. Genome Res. 2002)
    3. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. (PubMed id 17250611)1, 4, 9 Wang J.C....Goate A.M. (Alcohol. Clin. Exp. Res. 2007)
    4. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. (PubMed id 19782709)1, 4, 9 Dotson C.D....Steinle N.I. (Appetite 2010)
    5. Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. (PubMed id 18719631)1, 4, 9 Tepper B.J....Gasparini P. (Obesity (Silver Spring) 2008)
    6. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. (PubMed id 15466815)1, 4, 9 Prodi D.A....Angius A. (Chem. Senses 2004)
    7. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. (PubMed id 20675712)1, 4 Reed D.R....Wright M.J. (Hum. Mol. Genet. 2010)
    8. Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children. (PubMed id 19779476)1, 4 Keller K.L....Kissileff H.R. (Obesity (Silver Spring) 2010)
    9. Taste genes associated with dental caries. (PubMed id 20858777)1, 4 Wendell S....Marazita M.L. (J. Dent. Res. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5726 HGNC: 9584 AceView: TAS2R38 Ensembl:ENSG00000257138 euGenes: HUgn5726
    ECgene: TAS2R38 Kegg: 5726 H-InvDB: TAS2R38

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS2R38 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAS2R38 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/119

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAS2R38 gene:
    Search GeneIP for patents involving TAS2R38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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