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Aliases for TAS2R38 Gene

Aliases for TAS2R38 Gene

  • Taste 2 Receptor Member 38 2 3 5
  • Taste Receptor, Type 2, Member 38 2 3
  • Taste Receptor Type 2 Member 61 3 4
  • PTC Bitter Taste Receptor 3 4
  • T2R38 3 4
  • T2R61 3 4
  • PTC 3 4
  • Taste Receptor Type 2 Member 38 3
  • Phenylthiocarbamide Tasting 2

External Ids for TAS2R38 Gene

Previous HGNC Symbols for TAS2R38 Gene

  • PTC

Previous GeneCards Identifiers for TAS2R38 Gene

  • GC00U991247
  • GC07M141002
  • GC07M141079
  • GC07M141125
  • GC07M141318
  • GC07M141672
  • GC07M135968

Summaries for TAS2R38 Gene

Entrez Gene Summary for TAS2R38 Gene

  • This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

GeneCards Summary for TAS2R38 Gene

TAS2R38 (Taste 2 Receptor Member 38) is a Protein Coding gene. Diseases associated with TAS2R38 include Alexithymia and Dental Caries. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot for TAS2R38 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R38 Gene

Genomics for TAS2R38 Gene

Regulatory Elements for TAS2R38 Gene

Enhancers for TAS2R38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F142104 0.8 FANTOM5 Ensembl ENCODE 12.7 -131.4 -131377 2.0 SOX13 ELF3 SAP130 ARID4B MAX SIN3A ZNF384 CEBPG ZNF644 RARA TAS2R38 CLEC5A MGAM2
GH07F141995 0.2 ENCODE 12 -22.2 -22232 1.3 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS SP5 MXD4 TAS2R38 MGAM2
GH07F141999 0.7 ENCODE 12 -25.8 -25803 0.4 OSR2 ZNF263 KLF8 TCF7L2 TAS2R38 MGAM2
GH07F142000 0.6 ENCODE 11.5 -27.2 -27240 0.0 ZBTB48 IKZF1 ZNF600 ZIC2 ZBTB20 ZBTB17 TAS2R38 MGAM2
GH07F142001 0.6 ENCODE 11.5 -27.9 -27909 1.1 ASH2L ZIC2 GLIS2 ZBTB48 POLR2A PATZ1 FOS ZNF600 ZBTB20 MAZ TAS2R38 MGAM2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TAS2R38 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TAS2R38 gene promoter:

Genomic Location for TAS2R38 Gene

Chromosome:
7
Start:
141,972,631 bp from pter
End:
141,973,773 bp from pter
Size:
1,143 bases
Orientation:
Minus strand

Genomic View for TAS2R38 Gene

Genes around TAS2R38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R38 Gene

Proteins for TAS2R38 Gene

  • Protein details for TAS2R38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59533-T2R38_HUMAN
    Recommended name:
    Taste receptor type 2 member 38
    Protein Accession:
    P59533
    Secondary Accessions:
    • A4D1U6
    • P59552
    • Q2M3E8
    • Q645W3
    • Q86UK3

    Protein attributes for TAS2R38 Gene

    Size:
    333 amino acids
    Molecular mass:
    37892 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R38 Gene

Post-translational modifications for TAS2R38 Gene

  • Glycosylation at Asn 89 and Asn 178
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R38 Gene

Domains & Families for TAS2R38 Gene

Gene Families for TAS2R38 Gene

Protein Domains for TAS2R38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R38 Gene

Graphical View of Domain Structure for InterPro Entry

P59533

UniProtKB/Swiss-Prot:

T2R38_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R38: view

Function for TAS2R38 Gene

Molecular function for TAS2R38 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R38: view
genes like me logo Genes that share phenotypes with TAS2R38: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R38 Gene

Localization for TAS2R38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R38 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R38 Gene COMPARTMENTS Subcellular localization image for TAS2R38 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R38: view

Pathways & Interactions for TAS2R38 Gene

genes like me logo Genes that share pathways with TAS2R38: view

Pathways by source for TAS2R38 Gene

Interacting Proteins for TAS2R38 Gene

Gene Ontology (GO) - Biological Process for TAS2R38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R38: view

No data available for SIGNOR curated interactions for TAS2R38 Gene

Drugs & Compounds for TAS2R38 Gene

(6) Drugs for TAS2R38 Gene - From: BitterDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propylthiouracil Approved Pharma 8
Diphenidol Approved, Withdrawn Pharma 1
Methimazole Approved Pharma ICAM-1 inhibitor 0
Yohimbine Approved, Vet_approved Pharma Antagonist 27
Chlorpheniramine Pharma 69

(16) Additional Compounds for TAS2R38 Gene - From: BitterDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Methyl-2-thiouracil
acetylthiourea
Allyl isothiocyanate
  • 2-Propenyl isothiocyanate
  • 3-Iso-Thiocyanatoprop-1-ene
  • 3-Isothiocyanato-1-propene
  • 3-Isothiocyanatoprop-1-ene
  • AITC
57-06-7
Caprolactam
dimethylthioformamide
genes like me logo Genes that share compounds with TAS2R38: view

Transcripts for TAS2R38 Gene

mRNA/cDNA for TAS2R38 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R38 Gene

No ASD Table

Relevant External Links for TAS2R38 Gene

GeneLoc Exon Structure for
TAS2R38
ECgene alternative splicing isoforms for
TAS2R38

Expression for TAS2R38 Gene

mRNA expression in normal human tissues for TAS2R38 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAS2R38 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAS2R38 Gene:

TAS2R38

SOURCE GeneReport for Unigene cluster for TAS2R38 Gene:

Hs.647085

mRNA Expression by UniProt/SwissProt for TAS2R38 Gene:

P59533-T2R38_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).
genes like me logo Genes that share expression patterns with TAS2R38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TAS2R38 Gene

Orthologs for TAS2R38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R38 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia TAS2R38 34 35
  • 80.13 (n)
cow
(Bos Taurus)
Mammalia TAS2R38 34 35
  • 76.54 (n)
mouse
(Mus musculus)
Mammalia Tas2r138 34 16 35
  • 76.54 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r138 34
  • 76.13 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R38 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS2R7 35
  • 21 (a)
OneToMany
Species where no ortholog for TAS2R38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R38 Gene

ENSEMBL:
Gene Tree for TAS2R38 (if available)
TreeFam:
Gene Tree for TAS2R38 (if available)

Paralogs for TAS2R38 Gene

genes like me logo Genes that share paralogs with TAS2R38: view

Variants for TAS2R38 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R38 Gene

T2R38_HUMAN-P59533
Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting) [MIM:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

Sequence variations from dbSNP and Humsavar for TAS2R38 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10246939 drug-response 141,972,804(+) CAGGA(C/T)GGCTG reference, missense
rs1726866 drug-response 141,972,905(-) CTGTG(C/T)TGCCT reference, missense
rs713598 drug-response 141,973,545(-) GGCAG(C/G)CACTG reference, missense
rs114288846 -- 141,972,870(+) GTCGC(A/G)CCACA reference, missense
rs114673657 -- 141,974,008(+) CTTCC(C/G)AGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R38 Gene

Variant ID Type Subtype PubMed ID
nsv524927 CNV gain 19592680
nsv831161 CNV loss 17160897

Variation tolerance for TAS2R38 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 82.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R38 Gene

Human Gene Mutation Database (HGMD)
TAS2R38
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R38

Disorders for TAS2R38 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TAS2R38 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alexithymia
dental caries
  • dental caries extending into pulp
common cold
  • acute coryza
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TAS2R38

Genetic Association Database (GAD)
TAS2R38
Human Genome Epidemiology (HuGE) Navigator
TAS2R38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R38
genes like me logo Genes that share disorders with TAS2R38: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS2R38 Gene

Publications for TAS2R38 Gene

  1. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. (PMID: 19782709) Dotson C.D. … Steinle N.I. (Appetite 2010) 3 22 46 64
  2. Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. (PMID: 18719631) Tepper B.J. … Gasparini P. (Obesity (Silver Spring) 2008) 3 22 46 64
  3. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. (PMID: 17250611) Wang J.C. … Goate A.M. (Alcohol. Clin. Exp. Res. 2007) 3 22 46 64
  4. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. (PMID: 15466815) Prodi D.A. … Angius A. (Chem. Senses 2004) 3 22 46 64
  5. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. (PMID: 12595690) Kim U.-K. … Drayna D.T. (Science 2003) 3 4 46 64

Products for TAS2R38 Gene

Sources for TAS2R38 Gene

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