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TAS2R30 Gene

protein-coding   GIFtS: 40
GCID: GC12M011285

Taste Receptor, Type 2, Member 30

(Previous names: taste receptor, type 2, member 47)
(Previous symbol: TAS2R47)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 2, Member 301 2     Taste Receptor Type 2 Member 472 3
TAS2R471 2 3     Taste Receptor T2R472
T2R302 3 5     Taste Receptor Type 2 Member 302
T2R472 3 5     Type 2 Taste Receptor Member 302
Taste Receptor, Type 2, Member 471 2     Type 2 Taste Receptor Member 472

External Ids:    HGNC: 191121   Entrez Gene: 2592932   Ensembl: ENSG000002561887   OMIM: 6139635   UniProtKB: P595413   

Export aliases for TAS2R30 gene to outside databases

Previous GC identifers: GC00U991285 GC12U900765 GC12M011182 GC12M011216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAS2R30 Gene:
TAS2R30 (taste receptor, type 2, member 30) is a protein-coding gene. Diseases associated with TAS2R30 include balkan nephropathy. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R30_HUMAN, P59541
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R30 gene promoter:
         Sox5   FOXO3   FOXO3b   FOXC1   POU2F1   FOXO4   POU2F1a   FOXO3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TAS2R30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

TAS2R30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R30 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011285:  view genomic region     (about GC identifiers)

Start:
11,285,557 bp from pter      End:
11,287,243 bp from pter
Size:
1,687 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571047 328,331-329,290      Chr12-,NW_003571050 363,939-364,898     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T2R30_HUMAN, P59541 (See protein sequence)
Recommended Name: Taste receptor type 2 member 30  
Size: 319 amino acids; 36792 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: Q645X7

Explore the universe of human proteins at neXtProt for TAS2R30: NX_P59541

Explore proteomics data for TAS2R30 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn161, Asn176

  • See TAS2R30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001091112.1  
    ENSEMBL proteins: 
     ENSP00000444736  
    Reactome Protein details: P59541

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R30
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry P59541

    ProtoNet protein and cluster: P59541

    UniProtKB/Swiss-Prot: T2R30_HUMAN, P59541
    Similarity: Belongs to the G-protein coupled receptor T2R family


    TAS2R30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R30_HUMAN, P59541
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    TAS2R30 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2R30_HUMAN, P59541: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    TAS2R30 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS2R30 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TAS2R30
        Bitter Taste Signaling

    2 Reactome Pathways for TAS2R30
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R30):
        Taste transduction


    TAS2R30 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R30
    Interactions:

        Search GeneGlobe Interaction Network for TAS2R30

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050909sensory perception of taste IEA--

    TAS2R30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS2R30 (T2R30)

    10 BitterDB Bitter Compounds for TAS2R30    About this table
    CompoundSMILES CAS #
    AbsinthinC[C@H]1[C@@H]2CC[C@](C)(O)[C@@H]3[C@H]4[C@@H]5C=C(C)[C@@]6([C@H]7OC(=O)[C@@H](C)[C@@H]7CC[C@](C)(O)[C@H]56)[C@H]4C(=C3[C@H]2OC1=O)C1362-42-1
    amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
    andrographolideC[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](CC=C3/[C@H](O)COC3=O)C(=C)CC[C@H]125508-58-7
    ArtemorinCC1=C/[C@H]2OC(=O)C(=C)[C@@H]2CCC(=C)[C@H](O)CC1--
    CampherCC1(C)C2CCC1(C)C(=O)OC2=O--
    CascarillinC[C@@H]1[C@@H](C[C@]2(C)[C@H](CC[C@@H](O)[C@]2(C)O)[C@]1(C[C@@H](O)c3cocc3)C=O)OC(=O)C10118-56-6
    denatonium benzoateCC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc33734-33-6
    diphenidolOC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3--
    PicrotoxininCC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@]35C17617-45-7
    QuassinCOC1=C[C@@H](C)[C@@H]2C[C@H]3OC(=O)C[C@H]4C(=C(OC)C(=O)[C@@H]([C@@]34C)[C@@]2(C)C1=O)C76-78-8




    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAS2R30 gene: 
    NM_001097643.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000539585(uc009zhs.1)
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAS2R30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGTACTG
    TAS2R30 Expression
    About this image

    TAS2R30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS2R30 Protein Expression

    UniProtKB/Swiss-Prot: T2R30_HUMAN, P59541
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in
    gustducin-positive cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TAS2R30 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1365 taste receptor, type 2, member 136   --   6 (64.03 cM) 132777179 


    ENSEMBL Gene Tree for TAS2R30 (if available)
    TreeFam Gene Tree for TAS2R30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS2R30 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
    TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R12  TAS2R192  TAS2R72  TAS2R202  
    TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    Selected SIMAP similar genes for TAS2R30 using alignment to 1 protein entry:     T2R30_HUMAN(see all similar genes):
    Hosa(Biaka)-T2R47    Hosa(Adygei)-T2R46    Hosa(Biaka)-T2R46    TAS2R46    Hosa(Biaka)-T2R43    TAS2R43
    Hosa(Japanese)-T2R45    TAS2R31    TAS2R45    Hosa(Biaka)-T2R48    Hosa(Japanese)-T2R48    TAS2R50
    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R50    TAS2R19    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R49

    TAS2R30 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for TAS2R30    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25994041,2,4
    ----see VAR_0708092 mis40--------

    HapMap Linkage Disequilibrium report for TAS2R30 (11285557 - 11287243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TAS2R30:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv192e201CNV Deletion23290073
    dgv191e201CNV Deletion23290073
    dgv1374n71CNV Loss21882294
    nsv8917CNV Loss18304495
    dgv36e19CNV Loss19470904
    nsv428272CNV Gain+Loss18775914
    nsv511013CNV Complex20534489
    dgv476e1CNV Complex17122850
    dgv475e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613963    OMIM disorders: --

    1 disease for TAS2R30:    
    About MalaCards
    balkan nephropathy


    TAS2R30 for disorders           About GeneDecksing


    Export disorders for TAS2R30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS2R30 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TAS2R30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
    2. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (Cell 2003)
    3. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (J. Biol. Chem. 2002)
    4. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2 Bufe B.... Meyerhof W. (Nat. Genet. 2002)
    5. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)
    6. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (Genetics 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 259293 HGNC: 19112 Ensembl:ENSG00000256188 euGenes: HUgn259293 ECgene: TAS2R30 Kegg: 259293
    H-InvDB: TAS2R30

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS2R30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAS2R30 gene:
    Search GeneIP for patents involving TAS2R30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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