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Aliases for TAS2R30 Gene

Aliases for TAS2R30 Gene

  • Taste 2 Receptor Member 30 2 3 5
  • Taste Receptor, Type 2, Member 47 2 3
  • Taste Receptor, Type 2, Member 30 2 3
  • Taste Receptor Type 2 Member 47 3 4
  • TAS2R47 3 4
  • T2R30 3 4
  • T2R47 3 4
  • Type 2 Taste Receptor Member 30 3
  • Type 2 Taste Receptor Member 47 3
  • Taste Receptor T2R47 3

External Ids for TAS2R30 Gene

Previous HGNC Symbols for TAS2R30 Gene

  • TAS2R47

Previous GeneCards Identifiers for TAS2R30 Gene

  • GC00U991285
  • GC12U900765
  • GC12M011182
  • GC12M011216
  • GC12M011285
  • GC12M011079

Summaries for TAS2R30 Gene

GeneCards Summary for TAS2R30 Gene

TAS2R30 (Taste 2 Receptor Member 30) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R30 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R30 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R30 Gene

Genomics for TAS2R30 Gene

Regulatory Elements for TAS2R30 Gene

Genomic Location for TAS2R30 Gene

Chromosome:
12
Start:
11,132,958 bp from pter
End:
11,134,644 bp from pter
Size:
1,687 bases
Orientation:
Minus strand

Genomic View for TAS2R30 Gene

Genes around TAS2R30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R30 Gene

Proteins for TAS2R30 Gene

  • Protein details for TAS2R30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59541-T2R30_HUMAN
    Recommended name:
    Taste receptor type 2 member 30
    Protein Accession:
    P59541
    Secondary Accessions:
    • Q645X7

    Protein attributes for TAS2R30 Gene

    Size:
    319 amino acids
    Molecular mass:
    36874 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R30 Gene

Proteomics data for TAS2R30 Gene at MOPED

Post-translational modifications for TAS2R30 Gene

  • Glycosylation at Asn 161 and Asn 176
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R30 Gene

Domains & Families for TAS2R30 Gene

Gene Families for TAS2R30 Gene

Protein Domains for TAS2R30 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59541

UniProtKB/Swiss-Prot:

T2R30_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R30: view

Function for TAS2R30 Gene

Molecular function for TAS2R30 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R30 Gene

Localization for TAS2R30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R30 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R30 Gene COMPARTMENTS Subcellular localization image for TAS2R30 gene
Compartment Confidence
plasma membrane 4

No data available for Gene Ontology (GO) - Cellular Components for TAS2R30 Gene

Pathways & Interactions for TAS2R30 Gene

genes like me logo Genes that share pathways with TAS2R30: view

Pathways by source for TAS2R30 Gene

1 Qiagen pathway for TAS2R30 Gene

Interacting Proteins for TAS2R30 Gene

Gene Ontology (GO) - Biological Process for TAS2R30 Gene

None

No data available for SIGNOR curated interactions for TAS2R30 Gene

Drugs & Compounds for TAS2R30 Gene

(3) Drugs for TAS2R30 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphenidol Approved, Withdrawn Pharma 1
Andrographolide Pharma NF-κB signaling Inhibitor, Inhibits NFkappaB; blocks androgen receptor (AR) expression 6
Picrotoxinin Pharma Channel blocker 0

(7) Additional Compounds for TAS2R30 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
amarogentin
21018-84-8
Artemorin
Campher
Cascarillin
  • Cascarillin
10118-56-6
genes like me logo Genes that share compounds with TAS2R30: view

Transcripts for TAS2R30 Gene

mRNA/cDNA for TAS2R30 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R30 Gene

Taste receptor, type 2, member 30:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R30 Gene

No ASD Table

Relevant External Links for TAS2R30 Gene

GeneLoc Exon Structure for
TAS2R30
ECgene alternative splicing isoforms for
TAS2R30

Expression for TAS2R30 Gene

mRNA expression in normal human tissues for TAS2R30 Gene

SOURCE GeneReport for Unigene cluster for TAS2R30 Gene Hs.679464

mRNA Expression by UniProt/SwissProt for TAS2R30 Gene

P59541-T2R30_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R30: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R30 Gene

Orthologs for TAS2R30 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R30 35
  • 98.85 (n)
  • 97.49 (a)
PATR-T2R47 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
ManyToMany
TAS2R46 36
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 36
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 36
  • 49 (a)
ManyToMany
Tas2r136 36
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 31 (a)
ManyToMany
T2R24 36
  • 35 (a)
ManyToMany
T2R25 36
  • 34 (a)
ManyToMany
Species with no ortholog for TAS2R30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R30 Gene

ENSEMBL:
Gene Tree for TAS2R30 (if available)
TreeFam:
Gene Tree for TAS2R30 (if available)

Paralogs for TAS2R30 Gene

genes like me logo Genes that share paralogs with TAS2R30: view

Variants for TAS2R30 Gene

Sequence variations from dbSNP and Humsavar for TAS2R30 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_070809 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R30 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv8917 CNV Loss 18304495
dgv191e201 CNV Deletion 23290073
dgv1374n71 CNV Loss 21882294
dgv36e19 CNV Loss 19470904
nsv511013 CNV Complex 20534489
dgv192e201 CNV Deletion 23290073

Variation tolerance for TAS2R30 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R30 Gene

HapMap Linkage Disequilibrium report
TAS2R30
Human Gene Mutation Database (HGMD)
TAS2R30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R30 Gene

Disorders for TAS2R30 Gene

Relevant External Links for TAS2R30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R30

No disorders were found for TAS2R30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R30 Gene

Publications for TAS2R30 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 67
  2. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  3. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PMID: 15744053) Go Y. … Takahata N. (Genetics 2005) 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3

Products for TAS2R30 Gene

Sources for TAS2R30 Gene

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