TAS2R3 Gene
protein-coding GIFtS: 50
GCID: GC07P141463
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|
taste receptor, type 2, member 3
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Aliases
for TAS2R3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 2, Member 31 2 | | T2R31 2 3 5 | | Candidate Taste Receptor T2R32 | | Taste Receptor Type 2 Member 32 |
Export aliases for TAS2R3 gene to outside databasesPrevious GC identifers: GC07P139734 GC07P140795 GC07P140871 GC07P140918 GC07P141110 GC07P135760 |
Summaries
for TAS2R3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R3:
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptorsuperfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. Theseapparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter tastereceptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is geneticallylinked to loci that influence bitter perception. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TA2R3_HUMAN, Q9NYW6Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and thegastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Gene Wiki entry for TAS2R3
|
Genomic Views
for TAS2R3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R3 gene promoter:
AhR Bach2 Gfi-1 Evi-1 Arnt AREB6 FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.3-q32 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q31.3-q32TAS2R3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P141463: view genomic region
(about GC identifiers)
Start:
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141,463,897 bp from pter |
End:
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141,464,997 bp from pter |
Size:
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1,101 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 140,801,598-140,802,698 |
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Proteins
for TAS2R3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TA2R3_HUMAN, Q9NYW6 (See
protein sequence)Recommended Name: Taste receptor type 2 member 3 Size: 316 amino acids; 35915 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell
Sequence caution: Sequence=AAU21157.1; Type=Erroneous initiation;
Secondary accessions: A4D1U2 Q645W2 Q75MV6Explore the universe of human proteins at neXtProt for TAS2R3: NX_Q9NYW6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYW6
TAS2R3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_058639.1
ENSEMBL proteins: ENSP00000247879
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TAS2R3 for ontologies About GeneDecksing
TAS2R3 Antibody Products:
Assay Products for TAS2R3: |
Protein
Domains /
Families
for TAS2R3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NYW6ProtoNet protein and cluster: Q9NYW6 UniProtKB/Swiss-Prot: TA2R3_HUMAN, Q9NYW6Similarity: Belongs to the G-protein coupled receptor T2R family |
Function
for TAS2R3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TA2R3_HUMAN, Q9NYW6Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and thegastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TAS2R3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TAS2R3:
|
Pathways & Interactions
for TAS2R3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Taste transduction | | | 2 | Sweet Taste Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R3
1 
Kegg Pathway (Kegg details for TAS2R3):
TAS2R3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TAS2R3 (ENSP000002478794) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TAS2R3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS2R3
1 HMDB Compound for TAS2R3 About this table
1 BitterDB Bitter Compound for TAS2R3
| Compound | SMILES |
CAS
# |
|---|
| chloroquine | CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 | 54-05-7 |
About this table
Search CenterWatch for drugs/clinical trials and news about TAS2R3 / TA2R3
|
Transcripts
for TAS2R3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS2R3 gene: NM_016943.2 Unigene Cluster for TAS2R3: Taste receptor, type 2, member 3 Hs.676011 [show with all ESTs]Unigene Representative Sequence: BC0955231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000247879(uc003vwp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS2R3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS2R3 (NM_176817) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS2R3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R3 |
Additional cDNA sequence: BC069337.1 BC095523.1 1 DOTS entry: DT.91924584 3 AceView cDNA sequences: CF147795 NM_016943 BC069337
GeneLoc Exon Structure
|
Expression
for TAS2R3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS2R3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TAS2R3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS2R3
SOURCE GeneReport for Unigene cluster: Hs.676011
UniProtKB/Swiss-Prot: TA2R3_HUMAN, Q9NYW6Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively ingustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrinecells
SABiosciences Custom PCR Arrays for TAS2R3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS2R3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS2R3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R3 |
Orthologs
for TAS2R3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAS2R3 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for TAS2R3 (if available)
TreeFam Gene Tree for TAS2R3 (if available) |
Paralogs
for TAS2R3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAS2R3 gene
- TAS2R52 TAS2R412 TAS2R462 TAS2R162 TAS2R142 TAS2R432 TAS2R392 TAS2R382
- TAS2R422 TAS2R92 TAS2R42 TAS2R12 TAS2R302 TAS2R192 TAS2R72 TAS2R202
- TAS2R82 TAS2R132 TAS2R402 TAS2R102 TAS2R502 TAS2R602 TAS2R312
18/66 SIMAP similar genes for TAS2R3 using alignment to 1 protein entry: TA2R3_HUMAN(see all similar genes):Hosa(Adygei)-T2R3 Hosa(Biaka)-T2R3 Hosa(Adygei)-T2R7 Hosa(Biaka)-T2R7 Hosa(Biaka)-T2R8 Hosa(Japanese)-T2R8
TAS2R7 TAS2R8 TAS2R9 Hosa(Adygei)-T2R55 Hosa(Biaka)-T2R55 Hosa(Adygei)-T2R10
Hosa(Biaka)-T2R10 Hosa(Japanese)-T2R10 Hosa(Japanese)-T2R55 TAS2R10 Hosa(Biaka)-T2R43 TAS2R42
TAS2R3 for paralogs About GeneDecksing
|
Genomic Variants
for TAS2R3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAS2R3 (141463897 - 141464997 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAS2R3
1 CNV: 47923
Human Gene Mutation Database (HGMD): TAS2R3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R3 |
|
Disorders
/ Diseases
for TAS2R3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TAS2R3 for disorders About MalaCards
TAS2R3 for disorders About GeneDecksing
OMIM gene information: 604868
OMIM disorders: --
Export disorders for TAS2R3 gene to outside databases
|
Publications
for TAS2R3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS2R3 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TAS2R3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)
- A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2 Adler E....Zuker C.S. (2000)
- Patients with phantogeusia show increased expression o f T2R taste receptor genes in their tongues. (PubMed id 22397221)1 Hirai R....Ikeda M. (2012)
|
External Searches for TAS2R3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS2R3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS2R3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAS2R3 gene:
Search GeneIP for patents involving TAS2R3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAS2R3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS2R3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAS2R3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS2R3 |
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 |  |  |  | |
| | | | Search Tocris compounds for TAS2R3 |
| |  |  |  |  | | | | |
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 | | | TAS2R3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R3 |
|  |  |  | | | | ThermoFisher Antibodies for TAS2R3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R3 |
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