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Aliases for TAS2R3 Gene

Aliases for TAS2R3 Gene

  • Taste 2 Receptor Member 3 2 3 5
  • Taste Receptor, Type 2, Member 3 2 3
  • T2R3 3 4
  • Candidate Taste Receptor T2R3 3

External Ids for TAS2R3 Gene

Previous GeneCards Identifiers for TAS2R3 Gene

  • GC07P139734
  • GC07P140795
  • GC07P140871
  • GC07P140918
  • GC07P141110
  • GC07P141463
  • GC07P135760
  • GC07P142609
  • GC07P142903

Summaries for TAS2R3 Gene

Entrez Gene Summary for TAS2R3 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R3 Gene

TAS2R3 (Taste 2 Receptor Member 3) is a Protein Coding gene. Among its related pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R3 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R3 Gene

Genomics for TAS2R3 Gene

Regulatory Elements for TAS2R3 Gene

Enhancers for TAS2R3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS2R3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R3 Gene

141,764,097 bp from pter
141,765,197 bp from pter
1,101 bases
Plus strand

Genomic View for TAS2R3 Gene

Genes around TAS2R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R3 Gene

Proteins for TAS2R3 Gene

  • Protein details for TAS2R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Taste receptor type 2 member 3
    Protein Accession:
    Secondary Accessions:
    • A4D1U2
    • Q645W2
    • Q75MV6

    Protein attributes for TAS2R3 Gene

    316 amino acids
    Molecular mass:
    35915 Da
    Quaternary structure:
    No Data Available
    • Several bitter taste receptors are expressed in a single taste receptor cell.
    • Sequence=AAU21157.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TAS2R3 Gene

Proteomics data for TAS2R3 Gene at MOPED

Post-translational modifications for TAS2R3 Gene

  • Glycosylation at Asn 166
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R3 Gene

Domains & Families for TAS2R3 Gene

Gene Families for TAS2R3 Gene

Protein Domains for TAS2R3 Gene


Suggested Antigen Peptide Sequences for TAS2R3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor T2R family.
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R3: view

Function for TAS2R3 Gene

Molecular function for TAS2R3 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
genes like me logo Genes that share phenotypes with TAS2R3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R3 Gene

Localization for TAS2R3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TAS2R3 Gene COMPARTMENTS Subcellular localization image for TAS2R3 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R3 Gene

Pathways & Interactions for TAS2R3 Gene

genes like me logo Genes that share pathways with TAS2R3: view

Pathways by source for TAS2R3 Gene

Interacting Proteins for TAS2R3 Gene

Gene Ontology (GO) - Biological Process for TAS2R3 Gene


No data available for SIGNOR curated interactions for TAS2R3 Gene

Drugs & Compounds for TAS2R3 Gene

(2) Drugs for TAS2R3 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chloroquine Approved Pharma Agonist 142
calcium Nutra 0
genes like me logo Genes that share compounds with TAS2R3: view

Transcripts for TAS2R3 Gene

mRNA/cDNA for TAS2R3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R3 Gene

Taste receptor, type 2, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R3 Gene

No ASD Table

Relevant External Links for TAS2R3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAS2R3 Gene

mRNA expression in normal human tissues for TAS2R3 Gene

SOURCE GeneReport for Unigene cluster for TAS2R3 Gene Hs.676011

mRNA Expression by UniProt/SwissProt for TAS2R3 Gene

Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.
genes like me logo Genes that share expression patterns with TAS2R3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R3 Gene

Orthologs for TAS2R3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TAS2R3 35
  • 79.26 (n)
  • 67.62 (a)
TAS2R3 36
  • 67 (a)
(Canis familiaris)
Mammalia TAS2R3 35
  • 80.83 (n)
  • 70.61 (a)
TAS2R3 36
  • 70 (a)
(Mus musculus)
Mammalia Tas2r137 35
  • 77.85 (n)
  • 64.22 (a)
Tas2r137 16
Tas2r137 36
  • 61 (a)
(Pan troglodytes)
Mammalia TAS2R3 35
  • 99.79 (n)
  • 100 (a)
TAS2R3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tas2r137 35
  • 77.6 (n)
  • 64.95 (a)
(Monodelphis domestica)
Mammalia TAS2R3 36
  • 51 (a)
Species with no ortholog for TAS2R3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R3 Gene

Gene Tree for TAS2R3 (if available)
Gene Tree for TAS2R3 (if available)

Paralogs for TAS2R3 Gene

genes like me logo Genes that share paralogs with TAS2R3: view

Variants for TAS2R3 Gene

Sequence variations from dbSNP and Humsavar for TAS2R3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs765007 -- 141,764,114(+) TTCTA(C/T)GTATC utr-variant-5-prime
rs765008 -- 141,763,756(+) GAGCC(G/T)CCTCC upstream-variant-2KB
rs6962760 -- 141,765,563(+) GCCTC(C/T)GGTGA downstream-variant-500B
rs12667706 -- 141,765,479(+) TACAT(A/G)GTAGA downstream-variant-500B
rs6965618 -- 141,763,103(+) TTTAT(C/T)TCCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R3 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Variation tolerance for TAS2R3 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R3 Gene

Disorders for TAS2R3 Gene

Relevant External Links for TAS2R3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TAS2R3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R3 Gene

Publications for TAS2R3 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 67
  2. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  3. Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues. (PMID: 22397221) Hirai R. … Ikeda M. (Ann. Otol. Rhinol. Laryngol. 2012) 3
  4. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  5. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. (PMID: 19372376) Calvo S.E. … Mootha V.K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

Products for TAS2R3 Gene

Sources for TAS2R3 Gene