Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAS2R3 Gene

Aliases for TAS2R3 Gene

  • Taste Receptor, Type 2, Member 3 2 3
  • T2R3 3 4 6
  • Taste Receptor Type 2 Member 3 3
  • Candidate Taste Receptor T2R3 3

External Ids for TAS2R3 Gene

Previous GeneCards Identifiers for TAS2R3 Gene

  • GC07P139734
  • GC07P140795
  • GC07P140871
  • GC07P140918
  • GC07P141110
  • GC07P141463
  • GC07P135760

Summaries for TAS2R3 Gene

Entrez Gene Summary for TAS2R3 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R3 Gene

TAS2R3 (Taste Receptor, Type 2, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R3 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R3 Gene

Genomics for TAS2R3 Gene

Regulatory Elements for TAS2R3 Gene

Genomic Location for TAS2R3 Gene

Start:
141,764,097 bp from pter
End:
141,765,197 bp from pter
Size:
1,101 bases
Orientation:
Plus strand

Genomic View for TAS2R3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R3 Gene

Proteins for TAS2R3 Gene

  • Protein details for TAS2R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW6-TA2R3_HUMAN
    Recommended name:
    Taste receptor type 2 member 3
    Protein Accession:
    Q9NYW6
    Secondary Accessions:
    • A4D1U2
    • Q645W2
    • Q75MV6

    Protein attributes for TAS2R3 Gene

    Size:
    316 amino acids
    Molecular mass:
    35915 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell
    SequenceCaution:
    • Sequence=AAU21157.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TAS2R3 Gene

Proteomics data for TAS2R3 Gene at MOPED

Post-translational modifications for TAS2R3 Gene

  • Glycosylation at Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R3 Gene

Domains for TAS2R3 Gene

Gene Families for TAS2R3 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW6

UniProtKB/Swiss-Prot:

TA2R3_HUMAN :
  • Q9NYW6
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R3: view

Function for TAS2R3 Gene

Molecular function for TAS2R3 Gene

UniProtKB/Swiss-Prot Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R3: view

Phenotypes for TAS2R3 Gene

GenomeRNAi human phenotypes for TAS2R3:
genes like me logo Genes that share phenotypes with TAS2R3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R3 Gene

Localization for TAS2R3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R3 Gene COMPARTMENTS Subcellular localization image for TAS2R3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 10761934
genes like me logo Genes that share ontologies with TAS2R3: view

Pathways for TAS2R3 Gene

genes like me logo Genes that share pathways with TAS2R3: view

Pathways by source for TAS2R3 Gene

1 KEGG pathway for TAS2R3 Gene

Interacting Proteins for TAS2R3 Gene

Gene Ontology (GO) - Biological Process for TAS2R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction TAS 10761934
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste TAS 10761934
genes like me logo Genes that share ontologies with TAS2R3: view

Compounds for TAS2R3 Gene

(1) HMDB Compounds for TAS2R3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) BitterDB Compounds for TAS2R3 Gene

Compound Smiles Cas Number
chloroquine CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 54-05-7
genes like me logo Genes that share compounds with TAS2R3: view

Transcripts for TAS2R3 Gene

mRNA/cDNA for TAS2R3 Gene

(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R3 Gene

Taste receptor, type 2, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAS2R3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R3 Gene

No ASD Table

Relevant External Links for TAS2R3 Gene

GeneLoc Exon Structure for
TAS2R3
ECgene alternative splicing isoforms for
TAS2R3

Expression for TAS2R3 Gene

mRNA expression in normal human tissues for TAS2R3 Gene

SOURCE GeneReport for Unigene cluster for TAS2R3 Gene Hs.676011

mRNA Expression by UniProt/SwissProt for TAS2R3 Gene

Q9NYW6-TA2R3_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.
genes like me logo Genes that share expressions with TAS2R3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TAS2R3 Gene

Orthologs for TAS2R3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R3 35
  • 99.79 (n)
  • 100 (a)
TAS2R3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R3 35
  • 79.26 (n)
  • 67.62 (a)
TAS2R3 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R3 35
  • 80.83 (n)
  • 70.61 (a)
TAS2R3 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r137 35
  • 77.85 (n)
  • 64.22 (a)
Tas2r137 16
Tas2r137 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAS2R3 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r137 35
  • 77.6 (n)
  • 64.95 (a)
Species with no ortholog for TAS2R3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R3 Gene

ENSEMBL:
Gene Tree for TAS2R3 (if available)
TreeFam:
Gene Tree for TAS2R3 (if available)

Paralogs for TAS2R3 Gene

genes like me logo Genes that share paralogs with TAS2R3: view

Variants for TAS2R3 Gene

Sequence variations from dbSNP and Humsavar for TAS2R3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs765007 -- 141,764,114(+) TTCTA(C/T)GTATC utr-variant-5-prime
rs765008 -- 141,763,756(+) GAGCC(G/T)CCTCC upstream-variant-2KB
rs2270009 -- 141,764,965(+) ATTGG(C/T)GAAGT reference, synonymous-codon
rs4726475 -- 141,762,396(+) aggtg(C/T)ctggc upstream-variant-2KB
rs6962760 -- 141,765,563(+) GCCTC(C/T)GGTGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TAS2R3 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Relevant External Links for TAS2R3 Gene

HapMap Linkage Disequilibrium report
TAS2R3
Human Gene Mutation Database (HGMD)
TAS2R3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R3 Gene

Disorders for TAS2R3 Gene

No disorders were found for TAS2R3 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R3 Gene

Publications for TAS2R3 Gene

  1. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4

Products for TAS2R3 Gene

Sources for TAS2R3 Gene

Back to Top

Content