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Aliases for TAS2R20 Gene

Aliases for TAS2R20 Gene

  • Taste Receptor, Type 2, Member 20 2 3
  • T2R56 3 4 6
  • Taste Receptor, Type 2, Member 49 2 3
  • Taste Receptor Type 2 Member 56 3 4
  • Taste Receptor Type 2 Member 49 3 4
  • TAS2R49 3 4
  • T2R49 3 4
  • Taste Receptor Type 2 Member 20 3
  • T2R20 3

External Ids for TAS2R20 Gene

Previous HGNC Symbols for TAS2R20 Gene

  • TAS2R49

Previous GeneCards Identifiers for TAS2R20 Gene

  • GC00U991282
  • GC12U900764
  • GC12M011039
  • GC12M011148
  • GC12M010876

Summaries for TAS2R20 Gene

GeneCards Summary for TAS2R20 Gene

TAS2R20 (Taste Receptor, Type 2, Member 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R20 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R20 Gene

Genomics for TAS2R20 Gene

Regulatory Elements for TAS2R20 Gene

Genomic Location for TAS2R20 Gene

Start:
10,995,962 bp from pter
End:
10,997,875 bp from pter
Size:
1,914 bases
Orientation:
Minus strand

Genomic View for TAS2R20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R20 Gene

Proteins for TAS2R20 Gene

  • Protein details for TAS2R20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59543-T2R20_HUMAN
    Recommended name:
    Taste receptor type 2 member 20
    Protein Accession:
    P59543
    Secondary Accessions:
    • P59549
    • Q2HIZ4
    • Q496D8
    • Q645X9

    Protein attributes for TAS2R20 Gene

    Size:
    309 amino acids
    Molecular mass:
    35358 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R20 Gene

Proteomics data for TAS2R20 Gene at MOPED

Post-translational modifications for TAS2R20 Gene

  • Glycosylation at Asn161 and Asn176
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R20 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R20 Gene

Domains for TAS2R20 Gene

Gene Families for TAS2R20 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R20 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59543

UniProtKB/Swiss-Prot:

T2R20_HUMAN :
  • P59543
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R20: view

Function for TAS2R20 Gene

Molecular function for TAS2R20 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with TAS2R20: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R20 Gene

Localization for TAS2R20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R20 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R20 Gene COMPARTMENTS Subcellular localization image for TAS2R20 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TAS2R20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAS2R20: view

Pathways for TAS2R20 Gene

genes like me logo Genes that share pathways with TAS2R20: view

Pathways by source for TAS2R20 Gene

Interacting Proteins for TAS2R20 Gene

Gene Ontology (GO) - Biological Process for TAS2R20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R20: view

Compounds for TAS2R20 Gene

(2) BitterDB Compounds for TAS2R20 Gene

Compound Smiles Cas Number
cromolyn OC(COc1ccc2OC(=CC(=O)c2c1)C(=O)O)COc3cccc4OC(=CC(=O)c34)C(=O)O
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
genes like me logo Genes that share compounds with TAS2R20: view

Transcripts for TAS2R20 Gene

mRNA/cDNA for TAS2R20 Gene

(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R20 Gene

Taste receptor, type 2, member 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R20 Gene

No ASD Table

Relevant External Links for TAS2R20 Gene

GeneLoc Exon Structure for
TAS2R20
ECgene alternative splicing isoforms for
TAS2R20

Expression for TAS2R20 Gene

mRNA expression in normal human tissues for TAS2R20 Gene

SOURCE GeneReport for Unigene cluster for TAS2R20 Gene Hs.686384

mRNA Expression by UniProt/SwissProt for TAS2R20 Gene

P59543-T2R20_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TAS2R20 Gene

Orthologs for TAS2R20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R20 35
  • 99.57 (n)
  • 99.03 (a)
TAS2R20 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
ManyToMany
TAS2R46 36
  • 57 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 36
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 16
Tas2r120 36
  • 51 (a)
ManyToMany
Tas2r136 36
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 30 (a)
ManyToMany
T2R24 36
  • 34 (a)
ManyToMany
T2R25 36
  • 34 (a)
ManyToMany
Species with no ortholog for TAS2R20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R20 Gene

ENSEMBL:
Gene Tree for TAS2R20 (if available)
TreeFam:
Gene Tree for TAS2R20 (if available)

Paralogs for TAS2R20 Gene

genes like me logo Genes that share paralogs with TAS2R20: view

Variants for TAS2R20 Gene

Sequence variations from dbSNP and Humsavar for TAS2R20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_053356 -
VAR_053357 -
VAR_053358 -
VAR_053359 -
VAR_053360 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R20 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897
nsv898778 CNV Loss 21882294
esv2745546 CNV Deletion 23290073
nsv898779 CNV Loss 21882294
esv26197 CNV Gain 19812545
esv8289 CNV Loss 19470904
nsv898780 CNV Loss 21882294
nsv8915 CNV Gain 18304495
esv2664609 CNV Deletion 23128226

Relevant External Links for TAS2R20 Gene

HapMap Linkage Disequilibrium report
TAS2R20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R20 Gene

Disorders for TAS2R20 Gene

No disorders were found for TAS2R20 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R20 Gene

Publications for TAS2R20 Gene

  1. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  2. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  3. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PMID: 12584440) Conte C. … Andres-Barquin P.J. (Cytogenet. Genome Res. 2002) 3 4

Products for TAS2R20 Gene

Sources for TAS2R20 Gene

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