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Aliases for TAS2R19 Gene

Aliases for TAS2R19 Gene

  • Taste 2 Receptor Member 19 2 3 5
  • Taste Receptor, Type 2, Member 48 2 3
  • Taste Receptor, Type 2, Member 23 2 3
  • Taste Receptor, Type 2, Member 19 2 3
  • TAS2R23 3 4
  • TAS2R48 3 4
  • T2R48 3 4
  • Taste Receptor Type 2 Member 23 4
  • Taste Receptor Type 2 Member 48 4
  • MSTP058 3
  • T2R19 3
  • T2R23 3

External Ids for TAS2R19 Gene

Previous HGNC Symbols for TAS2R19 Gene

  • TAS2R48
  • TAS2R23

Previous GeneCards Identifiers for TAS2R19 Gene

  • GC00U991281
  • GC12U900775
  • GC12M011066
  • GC12M011174
  • GC12M010902

Summaries for TAS2R19 Gene

GeneCards Summary for TAS2R19 Gene

TAS2R19 (Taste 2 Receptor Member 19) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R19 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R19 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R19 Gene

Genomics for TAS2R19 Gene

Regulatory Elements for TAS2R19 Gene

Genomic Location for TAS2R19 Gene

Chromosome:
12
Start:
11,021,619 bp from pter
End:
11,022,620 bp from pter
Size:
1,002 bases
Orientation:
Minus strand

Genomic View for TAS2R19 Gene

Genes around TAS2R19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R19 Gene

Proteins for TAS2R19 Gene

  • Protein details for TAS2R19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59542-T2R19_HUMAN
    Recommended name:
    Taste receptor type 2 member 19
    Protein Accession:
    P59542
    Secondary Accessions:
    • Q3MIJ4
    • Q645X8

    Protein attributes for TAS2R19 Gene

    Size:
    299 amino acids
    Molecular mass:
    33908 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R19 Gene

Proteomics data for TAS2R19 Gene at MOPED

Post-translational modifications for TAS2R19 Gene

Other Protein References for TAS2R19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R19 Gene

Domains & Families for TAS2R19 Gene

Gene Families for TAS2R19 Gene

Protein Domains for TAS2R19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59542

UniProtKB/Swiss-Prot:

T2R19_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R19: view

Function for TAS2R19 Gene

Molecular function for TAS2R19 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
genes like me logo Genes that share phenotypes with TAS2R19: view

Animal Model Products

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Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R19 Gene

Localization for TAS2R19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R19 Gene COMPARTMENTS Subcellular localization image for TAS2R19 gene
Compartment Confidence
plasma membrane 5
extracellular 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TAS2R19 Gene

Pathways & Interactions for TAS2R19 Gene

genes like me logo Genes that share pathways with TAS2R19: view

Pathways by source for TAS2R19 Gene

Interacting Proteins for TAS2R19 Gene

Gene Ontology (GO) - Biological Process for TAS2R19 Gene

None

No data available for SIGNOR curated interactions for TAS2R19 Gene

Drugs & Compounds for TAS2R19 Gene

No Compound Related Data Available

Transcripts for TAS2R19 Gene

mRNA/cDNA for TAS2R19 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R19 Gene

Taste receptor, type 2, member 19:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R19 Gene

No ASD Table

Relevant External Links for TAS2R19 Gene

GeneLoc Exon Structure for
TAS2R19
ECgene alternative splicing isoforms for
TAS2R19

Expression for TAS2R19 Gene

mRNA expression in normal human tissues for TAS2R19 Gene

SOURCE GeneReport for Unigene cluster for TAS2R19 Gene Hs.688196

mRNA Expression by UniProt/SwissProt for TAS2R19 Gene

P59542-T2R19_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R19: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R19 Gene

Orthologs for TAS2R19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R19 35
  • 98.43 (n)
  • 96.31 (a)
TAS2R19 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
ManyToMany
TAS2R46 36
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 36
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 33 (a)
ManyToMany
T2R24 36
  • 34 (a)
ManyToMany
T2R25 36
  • 33 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r120 36
  • 49 (a)
ManyToMany
Tas2r136 36
  • 42 (a)
ManyToMany
Species with no ortholog for TAS2R19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R19 Gene

ENSEMBL:
Gene Tree for TAS2R19 (if available)
TreeFam:
Gene Tree for TAS2R19 (if available)

Paralogs for TAS2R19 Gene

genes like me logo Genes that share paralogs with TAS2R19: view

Variants for TAS2R19 Gene

Sequence variations from dbSNP and Humsavar for TAS2R19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_053354 -
VAR_053355 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R19 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897
esv2745546 CNV Deletion 23290073
nsv898779 CNV Loss 21882294
esv8289 CNV Loss 19470904
nsv898780 CNV Loss 21882294
esv2664609 CNV Deletion 23128226
esv2670207 CNV Deletion 23128226
dgv265e199 CNV Deletion 23128226
dgv35e19 CNV Loss 19470904
nsv8917 CNV Loss 18304495
esv24685 CNV Loss 19812545
dgv191e201 CNV Deletion 23290073
nsv514646 CNV Complex 21397061
dgv266e199 CNV Deletion 23128226

Variation tolerance for TAS2R19 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R19 Gene

HapMap Linkage Disequilibrium report
TAS2R19
Human Gene Mutation Database (HGMD)
TAS2R19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R19 Gene

Disorders for TAS2R19 Gene

Relevant External Links for TAS2R19

Human Genome Epidemiology (HuGE) Navigator
TAS2R19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R19

No disorders were found for TAS2R19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R19 Gene

Publications for TAS2R19 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 67
  2. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 3
  3. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. (PMID: 20675712) Reed D.R. … Wright M.J. (Hum. Mol. Genet. 2010) 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  5. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PMID: 15744053) Go Y. … Takahata N. (Genetics 2005) 3

Products for TAS2R19 Gene

Sources for TAS2R19 Gene

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