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Aliases for TAS2R19 Gene

Aliases for TAS2R19 Gene

  • Taste Receptor, Type 2, Member 19 2 3
  • T2R48 3 4 6
  • Taste Receptor, Type 2, Member 48 2 3
  • Taste Receptor, Type 2, Member 23 2 3
  • TAS2R23 3 4
  • TAS2R48 3 4
  • T2R19 3 6
  • Taste Receptor Type 2 Member 19 3
  • Taste Receptor Type 2 Member 23 4
  • Taste Receptor Type 2 Member 48 4
  • MSTP058 3
  • T2R23 3

External Ids for TAS2R19 Gene

Previous Symbols for TAS2R19 Gene

  • TAS2R48
  • TAS2R23

Summaries for TAS2R19 Gene

GeneCards Summary for TAS2R19 Gene

TAS2R19 (Taste Receptor, Type 2, Member 19) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R19 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R19 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R19 Gene

Genomics for TAS2R19 Gene

Genomic Location for TAS2R19 Gene

Start:
11,021,619 bp from pter
End:
11,022,620 bp from pter
Size:
1,002 bases
Orientation:
Minus strand

Genomic View for TAS2R19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R19 Gene

Regulatory Elements for TAS2R19 Gene

Proteins for TAS2R19 Gene

  • Protein details for TAS2R19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59542-T2R19_HUMAN
    Recommended name:
    Taste receptor type 2 member 19
    Protein Accession:
    P59542
    Secondary Accessions:
    • Q3MIJ4
    • Q645X8

    Protein attributes for TAS2R19 Gene

    Size:
    299 amino acids
    Molecular mass:
    33908 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R19 Gene

Proteomics data for TAS2R19 Gene at MOPED

Post-translational modifications for TAS2R19 Gene

Other Protein References for TAS2R19 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R19 Gene

Domains for TAS2R19 Gene

Gene Families for TAS2R19 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R19 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T2R19_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • P59542
genes like me logo Genes that share domains with TAS2R19: view

Function for TAS2R19 Gene

Molecular function for TAS2R19 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0033038 NOT bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R19: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R19 Gene

Localization for TAS2R19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R19 Gene COMPARTMENTS Subcellular localization image for TAS2R19 gene
Compartment Confidence
plasma membrane 3
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TAS2R19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 20022913
genes like me logo Genes that share ontologies with TAS2R19: view

Pathways for TAS2R19 Gene

genes like me logo Genes that share pathways with TAS2R19: view

Pathways by source for TAS2R19 Gene

Interacting Proteins for TAS2R19 Gene

Gene Ontology (GO) - Biological Process for TAS2R19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 NOT detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R19: view

Transcripts for TAS2R19 Gene

mRNA/cDNA for TAS2R19 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R19 Gene

Taste receptor, type 2, member 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R19 Gene

No ASD Table

Relevant External Links for TAS2R19 Gene

GeneLoc Exon Structure for
TAS2R19
ECgene alternative splicing isoforms for
TAS2R19

Expression for TAS2R19 Gene

mRNA expression in normal human tissues for TAS2R19 Gene

SOURCE GeneReport for Unigene cluster for TAS2R19 Gene Hs.688196

mRNA Expression by UniProt/SwissProt for TAS2R19 Gene

P59542-T2R19_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R19: view

Orthologs for TAS2R19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R19 36
  • 98.43 (n)
  • 96.31 (a)
TAS2R19 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 59 (a)
ManyToMany
TAS2R46 37
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 37
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 37
  • 49 (a)
ManyToMany
Tas2r136 37
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 37
  • 33 (a)
ManyToMany
T2R24 37
  • 34 (a)
ManyToMany
T2R25 37
  • 33 (a)
ManyToMany
Species with no ortholog for TAS2R19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R19 Gene

ENSEMBL:
Gene Tree for TAS2R19 (if available)
TreeFam:
Gene Tree for TAS2R19 (if available)

Paralogs for TAS2R19 Gene

genes like me logo Genes that share paralogs with TAS2R19: view

Variants for TAS2R19 Gene

Sequence variations from dbSNP and Humsavar for TAS2R19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_053354 -
VAR_053355 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R19 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897
esv2745546 CNV Deletion 23290073
nsv898779 CNV Loss 21882294
esv8289 CNV Loss 19470904
nsv898780 CNV Loss 21882294
esv2664609 CNV Deletion 23128226
esv2670207 CNV Deletion 23128226
dgv265e199 CNV Deletion 23128226
dgv35e19 CNV Loss 19470904
nsv8917 CNV Loss 18304495
esv24685 CNV Loss 19812545
dgv191e201 CNV Deletion 23290073
nsv514646 CNV Complex 21397061
dgv266e199 CNV Deletion 23128226

Relevant External Links for TAS2R19 Gene

HapMap Linkage Disequilibrium report
TAS2R19
Human Gene Mutation Database (HGMD)
TAS2R19

Disorders for TAS2R19 Gene

Relevant External Links for TAS2R19

Human Genome Epidemiology (HuGE) Navigator
TAS2R19
genes like me logo Genes that share disorders with TAS2R19: view

No data available for UniProtKB/Swiss-Prot for TAS2R19 Gene

Publications for TAS2R19 Gene

  1. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  2. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  3. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R19 Gene

Sources for TAS2R19 Gene

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