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Aliases for TAS2R16 Gene

Aliases for TAS2R16 Gene

  • Taste Receptor, Type 2, Member 16 2 3
  • T2R16 3 4 6
  • Taste Receptor Type 2 Member 16 3
  • Candidate Taste Receptor T2R16 3

External Ids for TAS2R16 Gene

Previous GeneCards Identifiers for TAS2R16 Gene

  • GC07M121112
  • GC07M122175
  • GC07M122189
  • GC07M122228
  • GC07M122421
  • GC07M122634
  • GC07M116997

Summaries for TAS2R16 Gene

Entrez Gene Summary for TAS2R16 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R16 Gene

TAS2R16 (Taste Receptor, Type 2, Member 16) is a Protein Coding gene. Diseases associated with TAS2R16 include alcohol dependence. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R16 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R16 Gene

Genomics for TAS2R16 Gene

Regulatory Elements for TAS2R16 Gene

Genomic Location for TAS2R16 Gene

Start:
122,994,704 bp from pter
End:
122,995,700 bp from pter
Size:
997 bases
Orientation:
Minus strand

Genomic View for TAS2R16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R16 Gene

Proteins for TAS2R16 Gene

  • Protein details for TAS2R16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV7-T2R16_HUMAN
    Recommended name:
    Taste receptor type 2 member 16
    Protein Accession:
    Q9NYV7
    Secondary Accessions:
    • A4D0X2
    • Q502V3
    • Q549U8
    • Q645W1

    Protein attributes for TAS2R16 Gene

    Size:
    291 amino acids
    Molecular mass:
    33986 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Confers bitter perception of salicin to non-taster mice
    • Several bitter taste receptors are expressed in a single taste receptor cell

neXtProt entry for TAS2R16 Gene

Proteomics data for TAS2R16 Gene at MOPED

Post-translational modifications for TAS2R16 Gene

  • Glycosylation at Asn80 and Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R16 Gene

Domains for TAS2R16 Gene

Gene Families for TAS2R16 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYV7

UniProtKB/Swiss-Prot:

T2R16_HUMAN :
  • Q9NYV7
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R16: view

Function for TAS2R16 Gene

Molecular function for TAS2R16 Gene

UniProtKB/Swiss-Prot Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 16720576
GO:0033038 bitter taste receptor activity IDA 16720576
genes like me logo Genes that share ontologies with TAS2R16: view

Phenotypes for TAS2R16 Gene

genes like me logo Genes that share phenotypes with TAS2R16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R16 Gene

Localization for TAS2R16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R16 Gene COMPARTMENTS Subcellular localization image for TAS2R16 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16720576
GO:0005802 trans-Golgi network IDA 16720576
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 16720576
GO:0016021 integral component of membrane IC 10761934
genes like me logo Genes that share ontologies with TAS2R16: view

Pathways for TAS2R16 Gene

genes like me logo Genes that share pathways with TAS2R16: view

Pathways by source for TAS2R16 Gene

1 KEGG pathway for TAS2R16 Gene

Interacting Proteins for TAS2R16 Gene

Gene Ontology (GO) - Biological Process for TAS2R16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R16: view

Compounds for TAS2R16 Gene

(1) HMDB Compounds for TAS2R16 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(8) BitterDB Compounds for TAS2R16 Gene

Compound Smiles Cas Number
Amygdalin, D OCC1OC(OCC2OC(OC(C#N)c3ccccc3)C(O)C(O)C2O)C(O)C(O)C1O
Arbutin OC[C]1O[C@](Oc2ccc(O)cc2)[C](O)[C@](O)[C@]1O
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
D-salicin,Salicin OC[C]1O[C@](Oc2ccccc2CO)[C](O)[C@](O)[C@]1O 138-52-3
Helicin OC[C]1O[C@](Oc2ccccc2C=O)[C](O)[C@](O)[C@]1O
Phenyl beta-D-glucopyranoside OC[C]1O[C@](Oc2ccccc2)[C](O)[C@](O)[C@]1O 1464-44-4
sinigrin [K+].OC[C]1O[C@](SC(=NOS(=O)(=O)[O-])CC=C)[C](O)[C@](O)[C@]1O
Sodium Benzoate [Na+].[O-]C(=O)c1ccccc1
genes like me logo Genes that share compounds with TAS2R16: view

Transcripts for TAS2R16 Gene

mRNA/cDNA for TAS2R16 Gene

(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R16 Gene

Taste receptor, type 2, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R16 Gene

No ASD Table

Relevant External Links for TAS2R16 Gene

GeneLoc Exon Structure for
TAS2R16
ECgene alternative splicing isoforms for
TAS2R16

Expression for TAS2R16 Gene

mRNA expression in normal human tissues for TAS2R16 Gene

SOURCE GeneReport for Unigene cluster for TAS2R16 Gene Hs.272395

mRNA Expression by UniProt/SwissProt for TAS2R16 Gene

Q9NYV7-T2R16_HUMAN
Tissue specificity: Expressed in a subset of gustducin-positive taste receptor cells of the tongue
genes like me logo Genes that share expressions with TAS2R16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TAS2R16 Gene

Orthologs for TAS2R16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R16 35
  • 99.43 (n)
  • 98.96 (a)
TAS2R16 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R16 35
  • 73.2 (n)
  • 57.39 (a)
TAS2R16 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R16 36
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r118 35
  • 70.51 (n)
  • 53.85 (a)
Tas2r118 16
Tas2r118 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia T2R62 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tas2r118 35
  • 69.35 (n)
  • 52.8 (a)
chicken
(Gallus gallus)
Aves TAS2R7 36
  • 21 (a)
OneToMany
Species with no ortholog for TAS2R16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R16 Gene

ENSEMBL:
Gene Tree for TAS2R16 (if available)
TreeFam:
Gene Tree for TAS2R16 (if available)

Paralogs for TAS2R16 Gene

Pseudogenes.org Pseudogenes for TAS2R16 Gene

genes like me logo Genes that share paralogs with TAS2R16: view

Variants for TAS2R16 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R16 Gene

Q9NYV7-T2R16_HUMAN
The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780]

Sequence variations from dbSNP and Humsavar for TAS2R16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs702424 -- 122,996,359(-) AGCAT(C/T)GGAAT upstream-variant-2KB
rs846664 Pathogenic, - 122,995,119(-) GAAAA(G/T)TTTCA missense, reference
rs860170 - 122,994,970(-) AGCGC(A/G)CTTCA missense, reference
rs978739 -- 122,995,846(-) CCTAC(A/G)TTCAG upstream-variant-2KB
rs1204014 -- 122,994,789(-) CCTAC(A/G)TTGAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TAS2R16 Gene

Variant ID Type Subtype PubMed ID
nsv524192 CNV Gain 19592680

Relevant External Links for TAS2R16 Gene

HapMap Linkage Disequilibrium report
TAS2R16
Human Gene Mutation Database (HGMD)
TAS2R16

Disorders for TAS2R16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TAS2R16 Gene including...

Search for TAS2R16 Gene in MalaCards »

(1) OMIM Diseases for TAS2R16 Gene (604867)

(2) University of Copenhagen DISEASES for TAS2R16 Gene

Relevant External Links for TAS2R16

Genetic Association Database (GAD)
TAS2R16
Human Genome Epidemiology (HuGE) Navigator
TAS2R16
genes like me logo Genes that share disorders with TAS2R16: view

No data available for UniProtKB/Swiss-Prot for TAS2R16 Gene

Publications for TAS2R16 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  4. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4
  5. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PMID: 12379855) Bufe B. … Meyerhof W. (Nat. Genet. 2002) 3 4

Products for TAS2R16 Gene

Sources for TAS2R16 Gene

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