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TAS2R14 Gene

protein-coding   GIFtS: 50
GCID: GC12M011090

Taste Receptor, Type 2, Member 14

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 2, Member 141 2
T2R142 3 5
TRB12 3 5
Taste Receptor Family B Member 12 3
Taste Receptor Type 2 Member 142
Taste Receptor, Family B, Member 12

External Ids:    HGNC: 149201   Entrez Gene: 508402   Ensembl: ENSG000002121277   OMIM: 6047905   UniProtKB: Q9NYV83   

Export aliases for TAS2R14 gene to outside databases

Previous GC identifers: GC12M010794 GC12M011235 GC12M010991 GC12M010982


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAS2R14 Gene:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled
receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and
palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence
bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This
gene maps to the taste receptor gene cluster on chromosome 12p13. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAS2R14 Gene:
TAS2R14 (taste receptor, type 2, member 14) is a protein-coding gene. GO annotations related to this gene include bitter taste receptor activity and taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R14 gene promoter:
         STAT5B   ISGF-3   Pbx1a   STAT5A   POU2F2C   POU2F1   POU2F1a   Zic1   POU2F2B   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R14 promoter sequence
   Search Chromatin IP Primers for TAS2R14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

TAS2R14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R14 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011090:  view genomic region     (about GC identifiers)

Start:
11,090,005 bp from pter      End:
11,324,172 bp from pter
Size:
234,168 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571047 136,960-137,913      Chr12-,NW_003571050 136,960-137,913     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8 (See protein sequence)
Recommended Name: Taste receptor type 2 member 14  
Size: 317 amino acids; 36160 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: Q645X3

Explore the universe of human proteins at neXtProt for TAS2R14: NX_Q9NYV8

Explore proteomics data for TAS2R14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn153, Asn162, Asn171
  • Modification sites at PhosphoSitePlus

  • See TAS2R14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076411.1  
    ENSEMBL proteins: 
     ENSP00000441949  
    Reactome Protein details: Q9NYV8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R14
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9NYV8

    ProtoNet protein and cluster: Q9NYV8

    UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
    Similarity: Belongs to the G-protein coupled receptor T2R family


    Find genes that share domains with TAS2R14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R14_HUMAN, Q9NYV8
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0008527taste receptor activity TAS10761934
    GO:0033038bitter taste receptor activity IDA16720576
         
    Find genes that share ontologies with TAS2R14           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TAS2R14:
     Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TAS2R14

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T2R14_HUMAN, Q9NYV8: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IC16720576

    Find genes that share ontologies with TAS2R14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS2R14 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44


    Find genes that share SuperPaths with TAS2R14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TAS2R14
        Bitter Taste Signaling

    2 Reactome Pathways for TAS2R14
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R14):
        Taste transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R14
    Interactions:

        Search GeneGlobe Interaction Network for TAS2R14

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA16720576
    GO:0007186G-protein coupled receptor signaling pathway IC16720576
    GO:0050909sensory perception of taste ----

    Find genes that share ontologies with TAS2R14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for TAS2R14 (T2R14)

    Selected BitterDB Bitter Compounds for TAS2R14 (see all 46)    About this table
    CompoundSMILES CAS #
    (+/-) EquolOc1:c:c:c(:c:c:1)C2COc3:c:c(O):c:c:c:3C2--
    (-)-alpha ThujoneCC(C)[C@@]12C[C@@H]1[C@H](C)C(=O)C2--
    8-prenylnaringeninCC(=CCc1c(O)cc(O)c2C(=O)CC(Oc12)c3ccc(O)cc3)C--
    AbsinthinC[C@H]1[C@@H]2CC[C@](C)(O)[C@@H]3[C@H]4[C@@H]5C=C(C)[C@@]6([C@H]7OC(=O)[C@@H](C)[C@@H]7CC[C@](C)(O)[C@H]56)[C@H]4C(=C3[C@H]2OC1=O)C1362-42-1
    AdlupuloneCC[C@H](C)C(=O)C1=C(O)C(CC=C(C)C)(CC=C(C)C)C(=O)C(=C1O)CC=C(C)C--
    ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
    ArglabinCC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13--
    Aristolochic acidCOc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-]--
    ArtemorinCC1=C/[C@H]2OC(=O)C(=C)[C@@H]2CCC(=C)[C@H](O)CC1--
    AzathioprineCn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]--




    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAS2R14 gene: 
    NM_023922.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537503(uc010shi.2) ENST00000381852(uc001qzj.3)
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    16 AceView cDNA sequences:

    BU543118 NM_023922 BC069148 BV177263 BE350724 BE887379 BF437472 F37282 
    AA830804 BV177307 CR602702 AK123548 BF477730 AI954132 CR598768 AL134885 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAS2R14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAAGATG
    TAS2R14 Expression
    About this image

    TAS2R14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS2R14 Protein Expression

    UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and
    exclusively in gustducin-positive cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TAS2R14 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1401 , 5 taste receptor, type 2, member 1401, 5 66.56(n)1
    48.87(a)1
      6 (64.03 cM)5
    3876161  NM_021562.11  NP_067537.11 
     1330548555 


    ENSEMBL Gene Tree for TAS2R14 (if available)
    TreeFam Gene Tree for TAS2R14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS2R14 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R392  TAS2R382  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R82  
    TAS2R202  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    Selected SIMAP similar genes for TAS2R14 using alignment to 1 protein entry:     T2R14_HUMAN(see all similar genes):
    Hosa(Japanese)-T2R14    Hosa(Japanese)-T2R50    TAS2R50    Hosa(Adygei)-T2R46    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R13
    Hosa(Biaka)-T2R46    Hosa(Biaka)-T2R47    Hosa(Biaka)-T2R48    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R13    Hosa(Japanese)-T2R48
    Hosa(Japanese)-T2R49    TAS2R13    TAS2R19    TAS2R49    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R43

    Find genes that share paralogs with TAS2R14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for TAS2R14    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs169258681,2,4
    ----see VAR_0533472 mis40--------
    rs358042871,2,4
    ----see VAR_0620852 mis40--------

    HapMap Linkage Disequilibrium report for TAS2R14 (11090005 - 11324172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TAS2R14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898777CNV Loss21882294
    nsv832330CNV Gain17160897
    nsv428272CNV Gain+Loss18775914
    essv11102CNV CNV17122850
    dgv475e1CNV Complex17122850
    dgv476e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604790    OMIM disorders: --


    Find genes that share disorders with TAS2R14           About GenesLikeMe

    Genetic Association Database (GAD): TAS2R14
    Human Genome Epidemiology (HuGE) Navigator: TAS2R14 (1 document)

    Export disorders for TAS2R14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS2R14 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TAS2R14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (Cell 2000)
    2. A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. (PubMed id 20534144)1, 4 Campa D....Canzian F. (BMC Med. Genet. 2010)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (Cell 2003)
    7. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)
    8. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (J. Biol. Chem. 2002)
    9. T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (Cell 2000)
    10. A family of candidate taste receptors in human and mouse. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (Nature 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50840 HGNC: 14920 AceView: TAS2R14 Ensembl:ENSG00000212127 euGenes: HUgn50840
    ECgene: TAS2R14 Kegg: 50840 H-InvDB: TAS2R14

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS2R14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAS2R14 gene:
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    GeneCards and IP:
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