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Aliases for TAS2R14 Gene

Aliases for TAS2R14 Gene

  • Taste Receptor, Type 2, Member 14 2 3
  • Taste Receptor Family B Member 1 3 4
  • T2R14 3 4
  • TRB1 3 4
  • Taste Receptor, Family B, Member 1 3

External Ids for TAS2R14 Gene

Previous GeneCards Identifiers for TAS2R14 Gene

  • GC12M010794
  • GC12M011235
  • GC12M010991
  • GC12M010982
  • GC12M011090

Summaries for TAS2R14 Gene

Entrez Gene Summary for TAS2R14 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R14 Gene

TAS2R14 (Taste Receptor, Type 2, Member 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R14 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R14 Gene

Genomics for TAS2R14 Gene

Regulatory Elements for TAS2R14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAS2R14 Gene

Chromosome:
12
Start:
10,937,406 bp from pter
End:
11,171,573 bp from pter
Size:
234,168 bases
Orientation:
Minus strand

Genomic View for TAS2R14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TAS2R14 Gene

Proteins for TAS2R14 Gene

  • Protein details for TAS2R14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV8-T2R14_HUMAN
    Recommended name:
    Taste receptor type 2 member 14
    Protein Accession:
    Q9NYV8
    Secondary Accessions:
    • Q645X3

    Protein attributes for TAS2R14 Gene

    Size:
    317 amino acids
    Molecular mass:
    36160 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R14 Gene

Proteomics data for TAS2R14 Gene at MOPED

Post-translational modifications for TAS2R14 Gene

  • Glycosylation at Asn 153, Asn 162, and Asn 171
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R14 Gene

Domains & Families for TAS2R14 Gene

Gene Families for TAS2R14 Gene

Protein Domains for TAS2R14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYV8

UniProtKB/Swiss-Prot:

T2R14_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R14: view

Function for TAS2R14 Gene

Molecular function for TAS2R14 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 16720576
genes like me logo Genes that share ontologies with TAS2R14: view
genes like me logo Genes that share phenotypes with TAS2R14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R14 Gene

Localization for TAS2R14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R14 Gene COMPARTMENTS Subcellular localization image for TAS2R14 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 16720576
genes like me logo Genes that share ontologies with TAS2R14: view

Pathways & Interactions for TAS2R14 Gene

genes like me logo Genes that share pathways with TAS2R14: view

Pathways by source for TAS2R14 Gene

1 KEGG pathway for TAS2R14 Gene

Interacting Proteins for TAS2R14 Gene

Gene Ontology (GO) - Biological Process for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R14: view

No data available for SIGNOR curated interactions for TAS2R14 Gene

Drugs & Compounds for TAS2R14 Gene

(18) Drugs for TAS2R14 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 145
Carisoprodol Approved Pharma 23
Chlorhexidine Approved Pharma 364
chloroquine Approved Pharma Agonist 137
Chlorpheniramine Approved Pharma 54

(28) Additional Compounds for TAS2R14 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-alpha Thujone
(+/-) Equol
8-prenylnaringenin
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
Adlupulone
28374-71-2
genes like me logo Genes that share compounds with TAS2R14: view

Transcripts for TAS2R14 Gene

mRNA/cDNA for TAS2R14 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R14 Gene

Taste receptor, type 2, member 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R14 Gene

No ASD Table

Relevant External Links for TAS2R14 Gene

GeneLoc Exon Structure for
TAS2R14
ECgene alternative splicing isoforms for
TAS2R14

Expression for TAS2R14 Gene

mRNA expression in normal human tissues for TAS2R14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAS2R14 Gene



SOURCE GeneReport for Unigene cluster for TAS2R14 Gene Hs.679406

mRNA Expression by UniProt/SwissProt for TAS2R14 Gene

Q9NYV8-T2R14_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).
genes like me logo Genes that share expression patterns with TAS2R14: view

Protein tissue co-expression partners for TAS2R14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TAS2R14 Gene

Orthologs for TAS2R14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R14 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tas2r140 35
  • 66.56 (n)
  • 48.87 (a)
Tas2r140 16
Tas2r103 36
  • 49 (a)
OneToMany
Tas2r109 36
  • 45 (a)
OneToMany
Tas2r110 36
  • 45 (a)
OneToMany
Tas2r113 36
  • 50 (a)
OneToMany
Tas2r115 36
  • 47 (a)
OneToMany
Tas2r116 36
  • 51 (a)
OneToMany
Tas2r117 36
  • 42 (a)
OneToMany
Tas2r123 36
  • 44 (a)
OneToMany
Tas2r125 36
  • 50 (a)
OneToMany
Tas2r129 36
  • 43 (a)
OneToMany
Tas2r140 36
  • 48 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TAS2R14 35
  • 99.16 (n)
  • 98.74 (a)
TAS2R14 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r140 35
  • 67.64 (n)
  • 49.84 (a)
cow
(Bos Taurus)
Mammalia T2R65A 36
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R67 36
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 30 (a)
ManyToMany
T2R24 36
  • 35 (a)
ManyToMany
T2R25 36
  • 34 (a)
ManyToMany
Species with no ortholog for TAS2R14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R14 Gene

ENSEMBL:
Gene Tree for TAS2R14 (if available)
TreeFam:
Gene Tree for TAS2R14 (if available)

Paralogs for TAS2R14 Gene

genes like me logo Genes that share paralogs with TAS2R14: view

Variants for TAS2R14 Gene

Sequence variations from dbSNP and Humsavar for TAS2R14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_053347 -
VAR_062085 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R14 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
nsv898777 CNV Loss 21882294
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897

Variation tolerance for TAS2R14 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R14 Gene

HapMap Linkage Disequilibrium report
TAS2R14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R14 Gene

Disorders for TAS2R14 Gene

Relevant External Links for TAS2R14

Genetic Association Database (GAD)
TAS2R14
Human Genome Epidemiology (HuGE) Navigator
TAS2R14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R14
genes like me logo Genes that share disorders with TAS2R14: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R14 Gene

Publications for TAS2R14 Gene

  1. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 67
  2. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 67
  3. Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. (PMID: 21942422) Roland W.S. … Smit G. (J. Agric. Food Chem. 2011) 67
  4. The steroid glycoside H.g.-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells. (PMID: 20930049) Le NevAc B. … Gouka R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 67
  5. The molecular receptive ranges of human TAS2R bitter taste receptors. (PMID: 20022913) Meyerhof W. … Behrens M. (Chem. Senses 2010) 67

Products for TAS2R14 Gene

Sources for TAS2R14 Gene

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