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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R14 Gene

protein-coding   GIFtS: 52
GCID: GC12M011090

Taste Receptor, Type 2, Member 14

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 141 2
T2R142 3 5
TRB12 3 5
Taste Receptor Family B Member 12 3
Taste Receptor Type 2 Member 142
Taste Receptor, Family B, Member 12

External Ids:    HGNC: 149201   Entrez Gene: 508402   Ensembl: ENSG000002121277   OMIM: 6047905   UniProtKB: Q9NYV83   

Export aliases for TAS2R14 gene to outside databases

Previous GC identifers: GC12M010794 GC12M011235 GC12M010991 GC12M010982


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R14 Gene:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled
receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and
palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence
bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This
gene maps to the taste receptor gene cluster on chromosome 12p13. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAS2R14 Gene: 
TAS2R14 (taste receptor, type 2, member 14) is a protein-coding gene. Diseases associated with TAS2R14 include colorectal cancer, and among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include bitter taste receptor activity and taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R14 gene promoter:
         STAT5B   ISGF-3   Pbx1a   STAT5A   POU2F2C   POU2F1   POU2F1a   Zic1   POU2F2B   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

TAS2R14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R14 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011090:  view genomic region     (about GC identifiers)

Start:
11,090,005 bp from pter      End:
11,324,172 bp from pter
Size:
234,168 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571047 136,960-137,913      Chr12-,NW_003571050 136,960-137,913     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8 (See protein sequence)
Recommended Name: Taste receptor type 2 member 14  
Size: 317 amino acids; 36160 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: Q645X3

Explore the universe of human proteins at neXtProt for TAS2R14: NX_Q9NYV8

Explore proteomics data for TAS2R14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYV8

  • TAS2R14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAS2R14 Protein Expression
    REFSEQ proteins: NP_076411.1  
    ENSEMBL proteins: 
     ENSP00000441949  
    Reactome Protein details: Q9NYV8
    Human Recombinant Protein Products for TAS2R14: 
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    Cloud-Clone Corp. Proteins for TAS2R14 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IC16720576

    TAS2R14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R14 
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9NYV8

    ProtoNet protein and cluster: Q9NYV8

    UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
    Similarity: Belongs to the G-protein coupled receptor T2R family


    TAS2R14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R14_HUMAN, Q9NYV8
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0008527taste receptor activity TAS10761934
    GO:0033038bitter taste receptor activity IDA16720576
         
    TAS2R14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAS2R14:
     Synthetic lethal with imatinib 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAS2R14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class C/3 (Metabotropic glutamate/pheromone receptors)
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R14
        Bitter Taste Signaling

    5/6        Reactome Pathways for TAS2R14 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for TAS2R14):
        Taste transduction


    TAS2R14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R14

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA16720576
    GO:0007186G-protein coupled receptor signaling pathway IC16720576
    GO:0050909sensory perception of taste ----

    TAS2R14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAS2R14 (T2R14)

    10/46 BitterDB Bitter Compounds for TAS2R14 (see all 46) About this table
    CompoundSMILES CAS #
    (+/-) EquolOc1:c:c:c(:c:c:1)C2COc3:c:c(O):c:c:c:3C2--
    (-)-alpha ThujoneCC(C)[C@@]12C[C@@H]1[C@H](C)C(=O)C2--
    8-prenylnaringeninCC(=CCc1c(O)cc(O)c2C(=O)CC(Oc12)c3ccc(O)cc3)C--
    AbsinthinC[C@H]1[C@@H]2CC[C@](C)(O)[C@@H]3[C@H]4[C@@H]5C=C(C)[C@@]6([C@H]7OC(=O)[C@@H](C)[C@@H]7CC[C@](C)(O)[C@H]56)[C@H]4C(=C3[C@H]2OC1=O)C1362-42-1
    AdlupuloneCC[C@H](C)C(=O)C1=C(O)C(CC=C(C)C)(CC=C(C)C)C(=O)C(=C1O)CC=C(C)C--
    ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
    ArglabinCC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13--
    Aristolochic acidCOc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-]--
    ArtemorinCC1=C/[C@H]2OC(=O)C(=C)[C@@H]2CCC(=C)[C@H](O)CC1--
    AzathioprineCn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]--


    Search CenterWatch for drugs/clinical trials and news about TAS2R14 / T2R14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAS2R14 gene: 
    NM_023922.1  

    Unigene Clusters for TAS2R14:

    Taste receptor, type 2, member 14
    Hs.679406  [show with all ESTs], Hs.731575  [show with all ESTs]
    Unigene Representative Sequences: CD558711, AK123548
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537503(uc010shi.2) ENST00000381852(uc001qzj.3)
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    Additional mRNA sequence: 

    AB593028.1 AK123548.1 

    10 DOTS entries:

    DT.102843591  DT.91779880  DT.304360  DT.454227  DT.40231473  DT.121204148  DT.75160161  DT.92005496 
    DT.95331082  DT.95373109 

    16 AceView cDNA sequences:

    AA830804 CR602702 AI954132 CR598768 BF437472 BV177307 BC069148 AL134885 
    BF477730 F37282 BU543118 BV177263 BE887379 AK123548 BE350724 NM_023922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAS2R14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAAGATG
    TAS2R14 Expression
    About this image


    See TAS2R14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAS2R14

    SOURCE GeneReport for Unigene clusters: Hs.679406 Hs.731575

    UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and
    exclusively in gustducin-positive cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TAS2R14 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1401 , 5 taste receptor, type 2, member 1401, 5 66.56(n)1
    48.87(a)1
      6 (64.03 cM)5
    3876161  NM_021562.11  NP_067537.11 
     1330548555 


    ENSEMBL Gene Tree for TAS2R14 (if available)
    TreeFam Gene Tree for TAS2R14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAS2R14 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R392  TAS2R382  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R82  
    TAS2R202  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    18/55 SIMAP similar genes for TAS2R14 using alignment to 1 protein entry:     T2R14_HUMAN(see all similar genes):
    Hosa(Japanese)-T2R14    Hosa(Japanese)-T2R50    TAS2R50    Hosa(Adygei)-T2R46    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R13
    Hosa(Biaka)-T2R46    Hosa(Biaka)-T2R47    Hosa(Biaka)-T2R48    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R13    Hosa(Japanese)-T2R48
    Hosa(Japanese)-T2R49    TAS2R13    TAS2R19    TAS2R49    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R43

    TAS2R14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in TAS2R14 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0533474
    ----see VAR_0533472 T A mis40--------
    VAR_0620854
    ----see VAR_0620852 L F mis40--------

    HapMap Linkage Disequilibrium report for TAS2R14 (11090005 - 11324172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TAS2R14:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898777CNV Loss21882294
    nsv832330CNV Gain17160897
    nsv428272CNV Gain+Loss18775914
    essv11102CNV CNV17122850
    dgv475e1CNV Complex17122850
    dgv476e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604790    OMIM disorders: --

    2 diseases for TAS2R14:    About MalaCards
    colorectal cancer    


    TAS2R14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAS2R14
    Human Genome Epidemiology (HuGE) Navigator: TAS2R14 (1 document)

    Export disorders for TAS2R14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAS2R14 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TAS2R14)
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    1. A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
    2. A gene-wide investigation on polymorphisms in the tas te receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. (PubMed id 20534144)1, 4 Campa D....Canzian F. (2010)
    3. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
    7. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
    8. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
    9. A family of candidate taste receptors in human and mo use. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (2000)
    10. T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50840 HGNC: 14920 AceView: TAS2R14 Ensembl:ENSG00000212127 euGenes: HUgn50840
    ECgene: TAS2R14 Kegg: 50840 H-InvDB: TAS2R14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAS2R14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAS2R14 gene:
    Search GeneIP for patents involving TAS2R14

    GeneCards and IP:
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