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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R14 Gene

protein-coding   GIFtS: 50
GCID: GC12M011090

taste receptor, type 2, member 14

 Explore 1 disease affiliated with
TAS2R14 via our new
 Human Malady Compendium 
Biological research products
for TAS2R14
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 141 2
T2R141 2 3 5
TRB11 2 3 5
Taste Receptor Family B Member 12 3
Taste Receptor Type 2 Member 142
Taste Receptor, Family B, Member 12

External Ids:    HGNC: 149201   Entrez Gene: 508402   Ensembl: ENSG000002121277   OMIM: 6047905   UniProtKB: Q9NYV83   

Export aliases for TAS2R14 gene to outside databases

Previous GC identifers: GC12M010794 GC12M011235 GC12M010991 GC12M010982


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R14:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor
superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia.
They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in
mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste
receptor gene cluster on chromosome 12p13. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in
sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha
gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

Gene Wiki entry for TAS2R14


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R14 gene promoter:
         STAT5B   ISGF-3   Pbx1a   STAT5A   POU2F2C   POU2F1   POU2F1a   Zic1   POU2F2B   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

TAS2R14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R14 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M011090:  view genomic region     (about GC identifiers)

Start:
11,090,005 bp from pter      End:
11,324,172 bp from pter
Size:
234,168 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8 (See protein sequence)
Recommended Name: Taste receptor type 2 member 14  
Size: 317 amino acids; 36160 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can
discriminate among bitter stimuli
Secondary accessions: Q645X3

Explore the universe of human proteins at neXtProt for TAS2R14: NX_Q9NYV8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYV8

  • TAS2R14 Protein expression data from MOPED and PaxDb:    About this image 
    TAS2R14 Protein Expression
    REFSEQ proteins: NP_076411.1  
    ENSEMBL proteins: 
     ENSP00000441949  

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    Uscn Proteins for TAS2R14

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IC16720576

    TAS2R14 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TAS2R14 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9NYV8

    ProtoNet protein and cluster: Q9NYV8

    UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
    Similarity: Belongs to the G-protein coupled receptor T2R family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T2R14_HUMAN, Q9NYV8
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in
    sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha
    gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008527taste receptor activity TAS10761934
    GO:0033038bitter taste receptor activity IDA16720576
         
    TAS2R14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAS2R14:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TAS2R14 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Taste transduction
    Taste transduction1.00
    2Sweet Taste Signaling
    Bitter Taste Signaling0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R14
        Bitter Taste Signaling


    1         Kegg Pathway  (Kegg details for TAS2R14):
        Taste transduction


    TAS2R14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R14

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA16720576
    GO:0007186G-protein coupled receptor signaling pathway IC16720576
    GO:0050912detection of chemical stimulus involved in sensory perception of taste ----

    TAS2R14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAS2R14

    10/46 BitterDB Bitter Compounds for TAS2R14 (see all 46) About this table
    CompoundSMILES CAS #
    (+/-) EquolOc1:c:c:c(:c:c:1)C2COc3:c:c(O):c:c:c:3C2--
    (-)-alpha ThujoneCC(C)[C@@]12C[C@@H]1[C@H](C)C(=O)C2--
    8-prenylnaringeninCC(=CCc1c(O)cc(O)c2C(=O)CC(Oc12)c3ccc(O)cc3)C--
    AbsinthinC[C@H]1[C@@H]2CC[C@](C)(O)[C@@H]3[C@H]4[C@@H]5C=C(C)[C@@]6([C@H]7OC(=O)[C@@H](C)[C@@H]7CC[C@](C)(O)[C@H]56)[C@H]4C(=C3[C@H]2OC1=O)C1362-42-1
    AdlupuloneCC[C@H](C)C(=O)C1=C(O)C(CC=C(C)C)(CC=C(C)C)C(=O)C(=C1O)CC=C(C)C--
    ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
    ArglabinCC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13--
    Aristolochic acidCOc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-]--
    ArtemorinCC1=C/[C@H]2OC(=O)C(=C)[C@@H]2CCC(=C)[C@H](O)CC1--
    AzathioprineCn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]--

    Search CenterWatch for drugs/clinical trials and news about TAS2R14 / T2R14 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAS2R14 gene: 
    NM_023922.1  

    Unigene Clusters for TAS2R14:

    Taste receptor, type 2, member 14
    Hs.679406  [show with all ESTs], Hs.731575  [show with all ESTs]
    Unigene Representative Sequences: CD558711, AK123548
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537503(uc010shi.2) ENST00000381852(uc001qzj.3)

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    Additional cDNA sequence: 

    AB593028.1 AK123548.1 

    10 DOTS entries:

    DT.102843591  DT.91779880  DT.304360  DT.454227  DT.40231473  DT.121204148  DT.75160161  DT.92005496 
    DT.95331082  DT.95373109 

    16 AceView cDNA sequences:

    NM_023922 AK123548 BC069148 BF477730 BV177263 BF437472 BE887379 BV177307 
    AA830804 CR598768 CR602702 AI954132 BE350724 AL134885 F37282 BU543118 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAS2R14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAAAGATG
    TAS2R14 Expression
    About this image
    See TAS2R14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAS2R14

    SOURCE GeneReport for Unigene clusters: Hs.679406 Hs.731575

    UniProtKB/Swiss-Prot: T2R14_HUMAN, Q9NYV8
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in
    gustducin-positive cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TAS2R14 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves Q2AB81_CHICK6
    Taste receptor type 2
    22(a)
    possible ortholog
    3(112675246-112676211)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    30(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343381.1(254214-512591)
    GL343391.1(165866-166828)


    ENSEMBL Gene Tree for TAS2R14 (if available)
    TreeFam Gene Tree for TAS2R14 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAS2R14 gene
    TAS2R52  TAS2R412  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R392  TAS2R382  
    TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  TAS2R202  
    TAS2R82  TAS2R132  TAS2R402  TAS2R102  TAS2R502  TAS2R602  TAS2R312  
    18/55 SIMAP similar genes for TAS2R14 using alignment to 1 protein entry:     T2R14_HUMAN(see all similar genes):
    Hosa(Japanese)-T2R14    Hosa(Japanese)-T2R50    TAS2R50    Hosa(Adygei)-T2R46    Hosa(Adygei)-T2R50    Hosa(Biaka)-T2R13
    Hosa(Biaka)-T2R46    Hosa(Biaka)-T2R47    Hosa(Biaka)-T2R48    Hosa(Biaka)-T2R50    Hosa(Japanese)-T2R13    Hosa(Japanese)-T2R48
    Hosa(Japanese)-T2R49    TAS2R13    TAS2R19    TAS2R49    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R43

    TAS2R14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/78 NCBI SNPs in TAS2R14 are shown (see all 78    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38515851,2
    C,F--11090393(+) AATTAC/GTTTTT 2 -- ds5001 int13Minor allele frequency- G:0.01NA 142
    rs39362851,2
    C,F--11090438(+) AAAAAT/ATAAAA 2 -- ds5001 int14Minor allele frequency- A:0.02NA 262
    rs1398482031,2
    --11090575(+) ACATTA/GTAGGT 2 -- ds5001 int10--------
    rs1846479251,2
    --11090618(+) GATTGA/TTACAA 2 -- int1 ds50010--------
    rs1432933861,2
    --11090619(+) ATTGAG/TACAAA 2 -- int1 ds50010--------
    rs774922481,2
    F--11090746(+) AAGCAT/CATCTT 2 -- ds5001 int11Minor allele frequency- C:0.05WA 118
    rs1510258051,2
    C--11090879(+) TTTGTG/AACCTG 3 /H /Y mis1 int11Minor allele frequency- A:0.00NA 3822
    rs1403585241,2
    C--11091166(+) CAGTGT/CGCTGC 3 /H /R mis1 int11Minor allele frequency- C:0.00NA 4536
    rs1454279211,2
    C,F--11091181(+) TCTTGC/TGATGT 3 H R int1 mis11Minor allele frequency- T:0.00NA 4540
    rs1379674651,2
    C,F--11091189(+) TGTTTC/ACACAT 3 /W /C int1 mis11Minor allele frequency- A:0.00NA 4542

    HapMap Linkage Disequilibrium report for TAS2R14 (11090005 - 11324172 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TAS2R14
         2 CNVs: 3875 4769

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TAS2R14 for disorders           About GeneDecksing

    OMIM gene information: 604790    OMIM disorders: --

    1 disease for TAS2R14:    About MalaCards
    colorectal cancer

    Human Genome Epidemiology (HuGE) Navigator: TAS2R14 (1 document)

    Export disorders for TAS2R14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAS2R14 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TAS2R14)
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    1. A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
    2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
    6. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
    7. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
    8. A family of candidate taste receptors in human and mo use. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (2000)
    9. T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)
    10. Soy isoflavones and other isoflavonoids activate the h uman bitter taste receptors hTAS2R14 and hTAS2R39. (PubMed id 21942422)1 Roland W.S....Smit G. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50840 HGNC: 14920 AceView: TAS2R14 Ensembl:ENSG00000212127 euGenes: HUgn50840
    ECgene: TAS2R14 Kegg: 50840 H-InvDB: TAS2R14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAS2R14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAS2R14 gene:
    Search GeneIP for patents involving TAS2R14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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