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Aliases for TAS2R14 Gene

Aliases for TAS2R14 Gene

  • Taste Receptor, Type 2, Member 14 2 3
  • T2R14 3 4 6
  • TRB1 3 4 6
  • Taste Receptor Family B Member 1 3 4
  • Taste Receptor, Family B, Member 1 3
  • Taste Receptor Type 2 Member 14 3

External Ids for TAS2R14 Gene

Summaries for TAS2R14 Gene

Entrez Gene Summary for TAS2R14 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R14 Gene

TAS2R14 (Taste Receptor, Type 2, Member 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R14 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R14 Gene

Genomics for TAS2R14 Gene

Genomic Location for TAS2R14 Gene

Start:
10,937,406 bp from pter
End:
11,171,573 bp from pter
Size:
234,168 bases
Orientation:
Minus strand

Genomic View for TAS2R14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R14 Gene

Regulatory Elements for TAS2R14 Gene

Proteins for TAS2R14 Gene

  • Protein details for TAS2R14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV8-T2R14_HUMAN
    Recommended name:
    Taste receptor type 2 member 14
    Protein Accession:
    Q9NYV8
    Secondary Accessions:
    • Q645X3

    Protein attributes for TAS2R14 Gene

    Size:
    317 amino acids
    Molecular mass:
    36160 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R14 Gene

Proteomics data for TAS2R14 Gene at MOPED

Post-translational modifications for TAS2R14 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn153, Asn162, and Asn171

Other Protein References for TAS2R14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R14 Gene

Domains for TAS2R14 Gene

Gene Families for TAS2R14 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R14 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T2R14_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • Q9NYV8
genes like me logo Genes that share domains with TAS2R14: view

Function for TAS2R14 Gene

Molecular function for TAS2R14 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 16720576
genes like me logo Genes that share ontologies with TAS2R14: view

Phenotypes for TAS2R14 Gene

GenomeRNAi human phenotypes for TAS2R14:
genes like me logo Genes that share phenotypes with TAS2R14: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R14 Gene

Localization for TAS2R14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R14 Gene COMPARTMENTS Subcellular localization image for TAS2R14 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 16720576
genes like me logo Genes that share ontologies with TAS2R14: view

Pathways for TAS2R14 Gene

genes like me logo Genes that share pathways with TAS2R14: view

Pathways by source for TAS2R14 Gene

1 KEGG pathway for TAS2R14 Gene

Interacting Proteins for TAS2R14 Gene

Gene Ontology (GO) - Biological Process for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R14: view

Compounds for TAS2R14 Gene

(46) BitterDB Compounds for TAS2R14 Gene

Compound Smiles Cas Number
(-)-alpha Thujone CC(C)[C@@]12C[C@]1[C](C)C(=O)C2
(+/-) Equol Oc1:c:c:c(:c:c:1)C2COc3:c:c(O):c:c:c:3C2
8-prenylnaringenin CC(=CCc1c(O)cc(O)c2C(=O)CC(Oc12)c3ccc(O)cc3)C
Absinthin C[C]1[C@]2CC[C@](C)(O)[C@]3[C]4[C@]5C=C(C)[C@@]6([C]7OC(=O)[C@](C)[C@]7CC[C@](C)(O)[C]56)[C]4C(=C3[C]2OC1=O)C 1362-42-1
Adlupulone CC[C](C)C(=O)C1=C(O)C(CC=C(C)C)(CC=C(C)C)C(=O)C(=C1O)CC=C(C)C
Arborescin CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O
Arglabin CC1=CC[C@]23O[C@@]2(C)CC[C@]4[C](OC(=O)C4=C)[C]13
Aristolochic acid COc1cccc2c1cc(c3c(cc4OCOc4c23)C(=O)O)[N+](=O)[O-]
Artemorin CC1=C/[C]2OC(=O)C(=C)[C@]2CCC(=C)[C](O)CC1
Azathioprine Cn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]
Benzamide NC(=O)c1ccccc1
Benzoin OC(C(=O)c1ccccc1)c2ccccc2 119-53-9
Caffeine CN1C(=O)N(C)c2ncn(C)c2C1=O 58-08-2
Campher CC1(C)C2CCC1(C)C(=O)OC2=O
Carisoprodol CCCC(C)(COC(=O)N)COC(=O)NC(C)C 78-44-4
Cascarillin C[C@]1[C@](C[C@]2(C)[C](CC[C@](O)[C@]2(C)O)[C@]1(C[C@](O)c3cocc3)C=O)OC(=O)C 10118-56-6
Chlorhexidine NC(=N/C(=N/CCCCCCN=C(/N)N=C(/N)Nc1ccc(Cl)cc1)/N)Nc2ccc(Cl)cc2
chloroquine CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 54-05-7
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
cis-isocohumulone CC(C)C(=O)C1=C(O)[C@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
cis-isohumulone CC(C)CC(=O)C1=C(O)[C@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
cis-isoloadhumulone CC[C](C)C(=O)C1=C(O)[C@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
Coumarin O=C1Oc2ccccc2C=C1
Coumestrol Oc1ccc2c(OC(=O)c3c2oc4cc(O)ccc34)c1
Cucurbitacin B CC(=O)OC(C)(C)C=CC(=O)[C@](C)(O)C1[C](O)C[C@@]2(C)[C@]3CC=C4[C@](C[C](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
Diphenhydramine CN(C)CCOC(c1ccccc1)c2ccccc2 58-73-1
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
diphenylthiourea,sulfocarbanilide,sym-Diphenylthiourea,thiocarbanilide S=C(Nc1ccccc1)Nc2ccccc2 102-08-9
Divinyl sulfoxide C=CS(=O)C=C
Falcarindiol CCCCCCCC=C/[C](O)C#CC#C[C@](O)C=C
Flufenamic Acid OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F
Genistein Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
Haloperidol OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3
Isoxanthohumol COc1cc(O)c(CC=C(C)C)c2OC(CC(=O)c12)c3ccc(O)cc3
Lupulon,Lupulone CC(C)CC(=O)C1=C(O)C(=C(O)C(CC=C(C)C)(CC=C(C)C)C1=O)CC=C(C)C 468-28-0
Noscapine COc1ccc2[C](OC(=O)c2c1OC)[C@]3N(C)CCc4cc5OCOc5c(OC)c34
Papaverine COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Parthenolide CC1=C/CC[C@@]2(C)O[C]2[C]3OC(=O)C(=C)[C@]3CC1
Picrotoxinin CC(=C)[C@]1[C]2OC(=O)[C@]1[C@]3(O)C[C]4O[C@]45C(=O)O[C]2[C@]35C 17617-45-7
Quassin COC1=C[C@](C)[C@]2C[C]3OC(=O)C[C]4C(=C(OC)C(=O)[C@]([C@@]34C)[C@@]2(C)C1=O)C 76-78-8
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
Sodium Benzoate [Na+].[O-]C(=O)c1ccccc1
trans-isoadhumulone CC[C](C)C(=O)C1=C(O)[C@@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
trans-isocohumulone CC(C)C(=O)C1=C(O)[C@@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
trans-isohumulone CC(C)CC(=O)C1=C(O)[C@@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
Xanthohumol COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)C=Cc2ccc(O)cc2
genes like me logo Genes that share compounds with TAS2R14: view

Transcripts for TAS2R14 Gene

mRNA/cDNA for TAS2R14 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R14 Gene

Taste receptor, type 2, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R14 Gene

No ASD Table

Relevant External Links for TAS2R14 Gene

GeneLoc Exon Structure for
TAS2R14
ECgene alternative splicing isoforms for
TAS2R14

Expression for TAS2R14 Gene

mRNA expression in normal human tissues for TAS2R14 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TAS2R14 Gene

SOURCE GeneReport for Unigene cluster for TAS2R14 Gene Hs.679406

mRNA Expression by UniProt/SwissProt for TAS2R14 Gene

Q9NYV8-T2R14_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R14: view

Orthologs for TAS2R14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R14 36
  • 99.16 (n)
  • 98.74 (a)
TAS2R14 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia T2R65A 37
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R67 37
  • 40 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r103 37
  • 49 (a)
OneToMany
Tas2r109 37
  • 45 (a)
OneToMany
Tas2r110 37
  • 45 (a)
OneToMany
Tas2r113 37
  • 50 (a)
OneToMany
Tas2r115 37
  • 47 (a)
OneToMany
Tas2r116 37
  • 51 (a)
OneToMany
Tas2r117 37
  • 42 (a)
OneToMany
Tas2r123 37
  • 44 (a)
OneToMany
Tas2r125 37
  • 50 (a)
OneToMany
Tas2r129 37
  • 43 (a)
OneToMany
Tas2r140 36
  • 66.56 (n)
  • 48.87 (a)
Tas2r140 16
Tas2r140 37
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 37
  • 30 (a)
ManyToMany
T2R24 37
  • 35 (a)
ManyToMany
T2R25 37
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tas2r140 36
  • 67.64 (n)
  • 49.84 (a)
Species with no ortholog for TAS2R14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R14 Gene

ENSEMBL:
Gene Tree for TAS2R14 (if available)
TreeFam:
Gene Tree for TAS2R14 (if available)

Paralogs for TAS2R14 Gene

genes like me logo Genes that share paralogs with TAS2R14: view

Variants for TAS2R14 Gene

Sequence variations from dbSNP and Humsavar for TAS2R14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_053347 -
VAR_062085 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R14 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
nsv898777 CNV Loss 21882294
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897

Relevant External Links for TAS2R14 Gene

HapMap Linkage Disequilibrium report
TAS2R14

Disorders for TAS2R14 Gene

Relevant External Links for TAS2R14

Genetic Association Database (GAD)
TAS2R14
Human Genome Epidemiology (HuGE) Navigator
TAS2R14
genes like me logo Genes that share disorders with TAS2R14: view

No data available for UniProtKB/Swiss-Prot for TAS2R14 Gene

Publications for TAS2R14 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R14 Gene

  • antibodies-online proteins for TAS2R14
  • antibodies-online antibodies for TAS2R14
  • antibodies-online kits for TAS2R14

Sources for TAS2R14 Gene

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