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Aliases for TAS2R13 Gene

Aliases for TAS2R13 Gene

  • Taste 2 Receptor Member 13 2 3 5
  • Taste Receptor, Type 2, Member 13 2 3
  • T2R13 3 4
  • TRB3 3 4
  • Taste Receptor, Family B, Member 3 3
  • Taste Receptor Family B Member 3 4
  • Taste Receptor Type 2 Member 13 3

External Ids for TAS2R13 Gene

Previous GeneCards Identifiers for TAS2R13 Gene

  • GC12M010765
  • GC12M011205
  • GC12M010961
  • GC12M010952
  • GC12M011060

Summaries for TAS2R13 Gene

Entrez Gene Summary for TAS2R13 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R13 Gene

TAS2R13 (Taste 2 Receptor Member 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R14.

UniProtKB/Swiss-Prot for TAS2R13 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R13 Gene

Genomics for TAS2R13 Gene

Regulatory Elements for TAS2R13 Gene

Enhancers for TAS2R13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F011015 0.9 ENCODE 10.4 -106.5 -106541 2.0 ELF3 MLX ARID4B DMAP1 RAD21 RARA GATA4 ZNF366 CREM MIXL1 TAS2R64P TAS2R50 TAS2R13 ENSG00000256682 TAS2R19 TAS2R20
GH12F010890 0.3 FANTOM5 2.6 +18.9 18876 0.3 TAS2R20 TAS2R7 TAS2R13 TAS2R31 TAS2R14 TAS2R8 TAS2R12P GC12P010842
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R13 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R13 Gene

Chromosome:
12
Start:
10,907,926 bp from pter
End:
10,909,562 bp from pter
Size:
1,637 bases
Orientation:
Minus strand

Genomic View for TAS2R13 Gene

Genes around TAS2R13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R13 Gene

Proteins for TAS2R13 Gene

  • Protein details for TAS2R13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV9-T2R13_HUMAN
    Recommended name:
    Taste receptor type 2 member 13
    Protein Accession:
    Q9NYV9
    Secondary Accessions:
    • Q4G0I5
    • Q502V8
    • Q645X2

    Protein attributes for TAS2R13 Gene

    Size:
    303 amino acids
    Molecular mass:
    35118 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R13 Gene

Post-translational modifications for TAS2R13 Gene

  • Glycosylation at Asn 162 and Asn 166
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R13 Gene

Domains & Families for TAS2R13 Gene

Gene Families for TAS2R13 Gene

Protein Domains for TAS2R13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYV9

UniProtKB/Swiss-Prot:

T2R13_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R13: view

Function for TAS2R13 Gene

Molecular function for TAS2R13 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R13: view

Phenotypes for TAS2R13 Gene

GenomeRNAi human phenotypes for TAS2R13:
genes like me logo Genes that share phenotypes with TAS2R13: view

Animal Model Products

miRNA for TAS2R13 Gene

miRTarBase miRNAs that target TAS2R13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R13 Gene

Localization for TAS2R13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R13 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R13: view

Pathways & Interactions for TAS2R13 Gene

genes like me logo Genes that share pathways with TAS2R13: view

Pathways by source for TAS2R13 Gene

Interacting Proteins for TAS2R13 Gene

Selected Interacting proteins: Q9NYV9-T2R13_HUMAN for TAS2R13 Gene via IID

Gene Ontology (GO) - Biological Process for TAS2R13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with TAS2R13: view

No data available for SIGNOR curated interactions for TAS2R13 Gene

Drugs & Compounds for TAS2R13 Gene

(1) Drugs for TAS2R13 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphenidol Approved, Withdrawn Pharma 1

(1) Additional Compounds for TAS2R13 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
denatonium benzoate
3734-33-6
genes like me logo Genes that share compounds with TAS2R13: view

Transcripts for TAS2R13 Gene

mRNA/cDNA for TAS2R13 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R13 Gene

Taste receptor, type 2, member 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R13 Gene

No ASD Table

Relevant External Links for TAS2R13 Gene

GeneLoc Exon Structure for
TAS2R13
ECgene alternative splicing isoforms for
TAS2R13

Expression for TAS2R13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R13 Gene

Protein differential expression in normal tissues from HIPED for TAS2R13 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAS2R13 Gene



Protein tissue co-expression partners for TAS2R13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAS2R13 Gene:

TAS2R13

SOURCE GeneReport for Unigene cluster for TAS2R13 Gene:

Hs.679407

mRNA Expression by UniProt/SwissProt for TAS2R13 Gene:

Q9NYV9-T2R13_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAS2R13 Gene

Orthologs for TAS2R13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R13 34 35
  • 98.57 (n)
mouse
(Mus musculus)
Mammalia Tas2r121 34 16 35
  • 72.32 (n)
Tas2r124 35
  • 48 (a)
OneToMany
Tas2r102 35
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tas2r121 34
  • 69.53 (n)
cow
(Bos Taurus)
Mammalia T2R12 35
  • 37 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R24 35
  • 36 (a)
ManyToMany
T2R23 35
  • 34 (a)
ManyToMany
T2R25 35
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R12 35
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia t2r8 34
  • 43.43 (n)
Species where no ortholog for TAS2R13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R13 Gene

ENSEMBL:
Gene Tree for TAS2R13 (if available)
TreeFam:
Gene Tree for TAS2R13 (if available)

Paralogs for TAS2R13 Gene

genes like me logo Genes that share paralogs with TAS2R13: view

Variants for TAS2R13 Gene

Sequence variations from dbSNP and Humsavar for TAS2R13 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036432 A breast cancer sample
rs1015443 --

Structural Variations from Database of Genomic Variants (DGV) for TAS2R13 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
nsv1038277 CNV loss 25217958

Variation tolerance for TAS2R13 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R13 Gene

Disorders for TAS2R13 Gene

Relevant External Links for TAS2R13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R13

No disorders were found for TAS2R13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R13 Gene

Publications for TAS2R13 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4 64
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4 64

Products for TAS2R13 Gene

Sources for TAS2R13 Gene

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