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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS2R10 Gene

protein-coding   GIFtS: 49
GCID: GC12M010977

Taste Receptor, Type 2, Member 10

  Search for TAS2R10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Taste Receptor, Type 2, Member 101 2
T2R102 3 5
TRB22 3 5
Taste Receptor Family B Member 22 3
Taste Receptor Type 2 Member 102
Taste Receptor, Family B, Member 22

External Ids:    HGNC: 149181   Entrez Gene: 508392   Ensembl: ENSG000001213187   OMIM: 6047915   UniProtKB: Q9NYW03   

Export aliases for TAS2R10 gene to outside databases

Previous GC identifers: GC12M010682 GC12M011122 GC12M010878 GC12M010869


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R10 Gene:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled
receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and
palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence
bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This
gene maps to the taste receptor gene cluster on chromosome 12p13. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAS2R10 Gene: 
TAS2R10 (taste receptor, type 2, member 10) is a protein-coding gene. Among its related super-pathways are Taste transduction and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: T2R10_HUMAN, Q9NYW0
Function: Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral
cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

Gene Wiki entry for TAS2R10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R10 gene promoter:
         HOXA3   Pbx1a   p53   FOXL1   MEF-2A   POU2F1   POU2F1a   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAS2R10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS2R10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

TAS2R10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010977:  view genomic region     (about GC identifiers)

Start:
10,977,916 bp from pter      End:
10,978,957 bp from pter
Size:
1,042 bases      Orientation:
minus strand

2 alternative locations:
Chr12-,NW_003571050 24,052-24,975      Chr12-,NW_003571047 24,052-24,975     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T2R10_HUMAN, Q9NYW0 (See protein sequence)
Recommended Name: Taste receptor type 2 member 10  
Size: 307 amino acids; 35365 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell
Secondary accessions: Q3MIM9 Q6NTD9

Explore the universe of human proteins at neXtProt for TAS2R10: NX_Q9NYW0

Explore proteomics data for TAS2R10 at MOPED 

TAS2R10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TAS2R10 Protein Expression

REFSEQ proteins: NP_076410.1  
ENSEMBL proteins: 
 ENSP00000240619  
Reactome Protein details: Q9NYW0
Human Recombinant Protein Products for TAS2R10: 
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Cloud-Clone Corp. Proteins for TAS2R10 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane NAS--

TAS2R10 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TASNR: GPCR / Unclassified : Taste receptors
TAS2R: Taste receptors / Type 2

IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R10 
Taste 2 receptors

1 InterPro protein domain:
 IPR007960 TAS2_rcpt

Graphical View of Domain Structure for InterPro Entry Q9NYW0

ProtoNet protein and cluster: Q9NYW0

UniProtKB/Swiss-Prot: T2R10_HUMAN, Q9NYW0
Similarity: Belongs to the G-protein coupled receptor T2R family


TAS2R10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: T2R10_HUMAN, Q9NYW0
Function: Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral
cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0008527taste receptor activity TAS10761934
     
TAS2R10 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TAS2R10 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
Taste transduction0.45
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71
G alpha (i) signalling events0.46
4Sweet Taste Signaling
Bitter Taste Signaling0.44

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS2R10
    Bitter Taste Signaling

5/6        Reactome Pathways for TAS2R10 (see all 6)
    GPCR downstream signaling
Signal Transduction
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by GPCR
G alpha (i) signalling events


1         Kegg Pathway  (Kegg details for TAS2R10):
    Taste transduction


TAS2R10 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R10

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TAS2R10 (ENSP000002406194) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GNAT3ENSP000003813394STRING: ENSP00000381339
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0008150biological_process ND--
GO:0050909sensory perception of taste ----
GO:0050912detection of chemical stimulus involved in sensory perception of taste TAS10761934

TAS2R10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS2R10 (T2R10)

1 HMDB Compound for TAS2R10    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

10/31 BitterDB Bitter Compounds for TAS2R10 (see all 31) About this table
CompoundSMILES CAS #
(-)-alpha ThujoneCC(C)[C@@]12C[C@@H]1[C@H](C)C(=O)C2--
AbsinthinC[C@H]1[C@@H]2CC[C@](C)(O)[C@@H]3[C@H]4[C@@H]5C=C(C)[C@@]6([C@H]7OC(=O)[C@@H](C)[C@@H]7CC[C@](C)(O)[C@H]56)[C@H]4C(=C3[C@H]2OC1=O)C1362-42-1
ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
ArglabinCC1=CC[C@]23O[C@@]2(C)CC[C@@H]4[C@H](OC(=O)C4=C)[C@H]13--
ArtemorinCC1=C/[C@H]2OC(=O)C(=C)[C@@H]2CCC(=C)[C@H](O)CC1--
AzathioprineCn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]--
Benzoin OC(C(=O)c1ccccc1)c2ccccc2119-53-9
CaffeineCN1C(=O)N(C)c2ncn(C)c2C1=O58-08-2
CampherCC1(C)C2CCC1(C)C(=O)OC2=O--
CascarillinC[C@@H]1[C@@H](C[C@]2(C)[C@H](CC[C@@H](O)[C@]2(C)O)[C@]1(C[C@@H](O)c3cocc3)C=O)OC(=O)C10118-56-6


Search CenterWatch for drugs/clinical trials and news about TAS2R10 / T2R10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAS2R10 gene: 
NM_023921.1  

Unigene Cluster for TAS2R10:

Taste receptor, type 2, member 10
Hs.533756  [show with all ESTs]
Unigene Representative Sequence: BC101764
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000240619(uc001qyy.1)
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS2R10

Additional mRNA sequence: 

BC069089.1 BC101762.1 BC101764.1 

1 DOTS entry:

DT.91917802 

6 AceView cDNA sequences:

NM_023921 CN839414 CN836251 BC069089 CN836429 CN839633 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAS2R10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TAS2R10 Expression
About this image


See TAS2R10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS2R10

SOURCE GeneReport for Unigene cluster: Hs.533756

UniProtKB/Swiss-Prot: T2R10_HUMAN, Q9NYW0
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and
exclusively in gustducin-positive cells

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TAS2R10 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tas2r1141 , 5 taste receptor, type 2, member 1141, 5 71.23(n)1
57(a)1
  6 (63.54 cM)5
3873461  NM_207019.11  NP_996902.11 
 1316891345 


ENSEMBL Gene Tree for TAS2R10 (if available)
TreeFam Gene Tree for TAS2R10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TAS2R10 gene
TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R12  TAS2R192  TAS2R72  
TAS2R202  TAS2R82  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
18/55 SIMAP similar genes for TAS2R10 using alignment to 1 protein entry:     T2R10_HUMAN(see all similar genes):
Hosa(Adygei)-T2R10    Hosa(Biaka)-T2R10    Hosa(Japanese)-T2R10    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R7    TAS2R7
TAS2R9    Hosa(Japanese)-T2R14    TAS2R14    TAS2R8    Hosa(Adygei)-T2R49    Hosa(Biaka)-T2R13
Hosa(Japanese)-T2R13    TAS2R13    Hosa(Adygei)-T2R3    Hosa(Biaka)-T2R3    Hosa(Biaka)-T2R49    Hosa(Biaka)-T2R55

TAS2R10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/93 SNPs in TAS2R10 are shown (see all 93)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2013092571,2
--10977445(+) AAATG-/AAAAAA 1 -- ds50010--------
rs1501755551,2
--10977501(+) CATCTA/CTCCTC 1 -- ds50010--------
rs1129276731,2
C,F--10977631(+) GTTTTC/ATTTTA 1 -- ds50012Minor allele frequency- A:0.50CSA 4
rs1454414241,2
--10977646(+) TTATTC/GTCACC 1 -- ds50010--------
rs108452191,2
C,F,A,H--10977654(+) ACCGTT/CATAAT 1 -- ds500129Minor allele frequency- C:0.50NA NS EA WA 2914
rs1488253411,2
C--10977821(+) TGGAAA/GATTTC 1 -- ds50010--------
rs782025691,2
F--10977843(+) ATGACA/GCAGTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs1434774021,2
C--10977946(+) GTGTCC/TATGTG 2 * W --0--------
rs1414397321,2
F--10978100(+) CAGCAG/ATTTGT 2 /L syn11Minor allele frequency- A:0.00NA 4524
rs1470016191,2
C--10978112(+) TTCTCG/ACACAG 2 /R /* stg11Minor allele frequency- A:0.00NA 4524

HapMap Linkage Disequilibrium report for TAS2R10 (10977916 - 10978957 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TAS2R10:    About this table     
Variant IDTypeSubtypePubMed ID
nsv898776CNV Loss21882294
dgv475e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TAS2R10
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAS2R10 for disorders           About MalaCards
OMIM gene information: 604791    OMIM disorders: --


TAS2R10 for disorders           About GeneDecksing


Export disorders for TAS2R10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAS2R10 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TAS2R10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
  2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
  3. The receptors and coding logic for bitter taste. (PubMed id 15759003)1, 2 Mueller K.L....Ryba N.J. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
  6. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
  7. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
  8. A family of candidate taste receptors in human and mo use. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (2000)
  9. T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)
  10. The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. (PubMed id 23283334)1 Born S....Behrens M. (2013)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 50839 HGNC: 14918 AceView: TAS2R10 Ensembl:ENSG00000121318 euGenes: HUgn50839
ECgene: TAS2R10 Kegg: 50839 H-InvDB: TAS2R10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TAS2R10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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