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Aliases for TAS2R10 Gene

Aliases for TAS2R10 Gene

  • Taste Receptor, Type 2, Member 10 2 3
  • T2R10 3 4 6
  • TRB2 3 4 6
  • Taste Receptor Family B Member 2 3 4
  • Taste Receptor, Family B, Member 2 3
  • Taste Receptor Type 2 Member 10 3

External Ids for TAS2R10 Gene

Summaries for TAS2R10 Gene

Entrez Gene Summary for TAS2R10 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R10 Gene

TAS2R10 (Taste Receptor, Type 2, Member 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R10 Gene

  • Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R10 Gene

Genomics for TAS2R10 Gene

Genomic Location for TAS2R10 Gene

Start:
10,815,927 bp from pter
End:
10,826,556 bp from pter
Size:
10,630 bases
Orientation:
Minus strand

Genomic View for TAS2R10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R10 Gene

Regulatory Elements for TAS2R10 Gene

Proteins for TAS2R10 Gene

  • Protein details for TAS2R10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW0-T2R10_HUMAN
    Recommended name:
    Taste receptor type 2 member 10
    Protein Accession:
    Q9NYW0
    Secondary Accessions:
    • Q3MIM9
    • Q6NTD9

    Protein attributes for TAS2R10 Gene

    Size:
    307 amino acids
    Molecular mass:
    35365 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell

neXtProt entry for TAS2R10 Gene

Proteomics data for TAS2R10 Gene at MOPED

Post-translational modifications for TAS2R10 Gene

  • Glycosylation at Asn92 and Asn158

Other Protein References for TAS2R10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R10 Gene

Domains for TAS2R10 Gene

Gene Families for TAS2R10 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R10 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T2R10_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • Q9NYW0
genes like me logo Genes that share domains with TAS2R10: view

Function for TAS2R10 Gene

Molecular function for TAS2R10 Gene

UniProtKB/Swiss-Prot Function: Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R10: view

miRNA for TAS2R10 Gene

miRTarBase miRNAs that target TAS2R10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAS2R10 Gene

Localization for TAS2R10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R10 Gene COMPARTMENTS Subcellular localization image for TAS2R10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R10: view

Pathways for TAS2R10 Gene

genes like me logo Genes that share pathways with TAS2R10: view

Pathways by source for TAS2R10 Gene

1 KEGG pathway for TAS2R10 Gene

Interacting Proteins for TAS2R10 Gene

Gene Ontology (GO) - Biological Process for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R10: view

Compounds for TAS2R10 Gene

(1) HMDB Compounds for TAS2R10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(31) BitterDB Compounds for TAS2R10 Gene

Compound Smiles Cas Number
(-)-alpha Thujone CC(C)[C@@]12C[C@]1[C](C)C(=O)C2
Absinthin C[C]1[C@]2CC[C@](C)(O)[C@]3[C]4[C@]5C=C(C)[C@@]6([C]7OC(=O)[C@](C)[C@]7CC[C@](C)(O)[C]56)[C]4C(=C3[C]2OC1=O)C 1362-42-1
Arborescin CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O
Arglabin CC1=CC[C@]23O[C@@]2(C)CC[C@]4[C](OC(=O)C4=C)[C]13
Artemorin CC1=C/[C]2OC(=O)C(=C)[C@]2CCC(=C)[C](O)CC1
Azathioprine Cn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-]
Benzoin OC(C(=O)c1ccccc1)c2ccccc2 119-53-9
Caffeine CN1C(=O)N(C)c2ncn(C)c2C1=O 58-08-2
Campher CC1(C)C2CCC1(C)C(=O)OC2=O
Cascarillin C[C@]1[C@](C[C@]2(C)[C](CC[C@](O)[C@]2(C)O)[C@]1(C[C@](O)c3cocc3)C=O)OC(=O)C 10118-56-6
chloramphenicol OC[C@](NC(=O)C(Cl)Cl)[C](O)c1ccc(cc1)[N+](=O)[O-]
chloroquine CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 54-05-7
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
Coumarin O=C1Oc2ccccc2C=C1
Cucurbitacin B CC(=O)OC(C)(C)C=CC(=O)[C@](C)(O)C1[C](O)C[C@@]2(C)[C@]3CC=C4[C@](C[C](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
cucurbitacin E,Cucurbitacins CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(C=C(O)C(=O)C4(C)C)C3(C)C(=O)CC12C 18444-66-1
cycloheximid,Cycloheximide C[C]1C[C](C)C(=O)[C@](C1)[C](O)CC2CC(=O)NC(=O)C2 66-81-9
dapsone Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
denatonium benzoate CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 3734-33-6
dextromethorphan COc1ccc2C[C@]3[C]4CCCC[C@]4(CCN3C)c2c1
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
erythromycin CC[C]1OC(=O)[C](C)[C@](O[C]2C[C@@](C)(OC)[C@](O)[C](C)O2)[C](C)[C@](O[C@]3O[C](C)C[C@]([C]3O)N(C)C)[C@](C)(O)C[C@](C)C(=O)[C](C)[C@](O)[C@]1(C)O
famotidine NC(=Nc1nc(CSCCC(=NS(=O)(=O)N)N)cs1)N
Haloperidol OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3
Papaverine COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Parthenolide CC1=C/CC[C@@]2(C)O[C]2[C]3OC(=O)C(=C)[C@]3CC1
Picrotoxinin CC(=C)[C@]1[C]2OC(=O)[C@]1[C@]3(O)C[C]4O[C@]45C(=O)O[C]2[C@]35C 17617-45-7
Quassin COC1=C[C@](C)[C@]2C[C]3OC(=O)C[C]4C(=C(OC)C(=O)[C@]([C@@]34C)[C@@]2(C)C1=O)C 76-78-8
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
strychnine O=C1C[C@]2OCC=C3CN4CC[C@@]56[C@]4C[C@]3[C@]2[C@]5N1c7ccccc67 57-24-9
yohimbine COC(=O)[C]1[C@](O)CC[C]2CN3CCc4c([nH]c5ccccc45)[C@]3C[C]12
genes like me logo Genes that share compounds with TAS2R10: view

Transcripts for TAS2R10 Gene

mRNA/cDNA for TAS2R10 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R10 Gene

Taste receptor, type 2, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R10 Gene

No ASD Table

Relevant External Links for TAS2R10 Gene

GeneLoc Exon Structure for
TAS2R10
ECgene alternative splicing isoforms for
TAS2R10

Expression for TAS2R10 Gene

mRNA expression in normal human tissues for TAS2R10 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TAS2R10 Gene

SOURCE GeneReport for Unigene cluster for TAS2R10 Gene Hs.533756

mRNA Expression by UniProt/SwissProt for TAS2R10 Gene

Q9NYW0-T2R10_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R10: view

Orthologs for TAS2R10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R10 36
  • 99.13 (n)
  • 98.05 (a)
TAS2R10 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BOTA-T2R10B 37
  • 62 (a)
OneToMany
T2R10C 37
  • 63 (a)
OneToMany
TAS2R10 36
  • 77.67 (n)
  • 63.97 (a)
TAS2R10 37
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TAS2R10 36
  • 84.16 (n)
  • 74.75 (a)
TAS2R10 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r104 37
  • 55 (a)
OneToMany
Tas2r105 37
  • 54 (a)
OneToMany
Tas2r106 37
  • 57 (a)
OneToMany
Tas2r107 37
  • 56 (a)
OneToMany
Tas2r114 36
  • 71.23 (n)
  • 57 (a)
Tas2r114 16
Tas2r114 37
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MODO-T2R28 37
  • 38 (a)
OneToMany
T2R22 37
  • 39 (a)
OneToMany
T2R26 37
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tas2r114 36
  • 71.77 (n)
  • 55.05 (a)
Species with no ortholog for TAS2R10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R10 Gene

ENSEMBL:
Gene Tree for TAS2R10 (if available)
TreeFam:
Gene Tree for TAS2R10 (if available)

Paralogs for TAS2R10 Gene

genes like me logo Genes that share paralogs with TAS2R10: view

Variants for TAS2R10 Gene

Sequence variations from dbSNP and Humsavar for TAS2R10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs592552 -- 10,816,031(+) GAGGA(A/G)AAGGC utr-variant-3-prime
rs592864 -- 10,827,717(-) tatac(A/G)gtcag upstream-variant-2KB
rs597468 - 10,825,803(+) TCTTC(A/G)TTTTA reference, missense
rs601051 -- 10,820,031(+) atcac(A/G)tgctc intron-variant
rs612456 -- 10,822,142(+) GCAAA(A/C)CCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAS2R10 Gene

Variant ID Type Subtype PubMed ID
nsv898776 CNV Loss 21882294
dgv475e1 CNV Complex 17122850

Relevant External Links for TAS2R10 Gene

HapMap Linkage Disequilibrium report
TAS2R10

Disorders for TAS2R10 Gene

No disorders were found for TAS2R10 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R10 Gene

Publications for TAS2R10 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R10 Gene

Sources for TAS2R10 Gene

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