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Aliases for TAS2R10 Gene

Aliases for TAS2R10 Gene

  • Taste 2 Receptor Member 10 2 3 5
  • Taste Receptor, Type 2, Member 10 2 3
  • T2R10 3 4
  • TRB2 3 4
  • Taste Receptor, Family B, Member 2 3
  • Taste Receptor Family B Member 2 4
  • Taste Receptor Type 2 Member 10 3

External Ids for TAS2R10 Gene

Previous GeneCards Identifiers for TAS2R10 Gene

  • GC12M010682
  • GC12M011122
  • GC12M010878
  • GC12M010869
  • GC12M010977

Summaries for TAS2R10 Gene

Entrez Gene Summary for TAS2R10 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R10 Gene

TAS2R10 (Taste 2 Receptor Member 10) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R9.

UniProtKB/Swiss-Prot for TAS2R10 Gene

  • Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R10 Gene

Additional gene information for TAS2R10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R10 Gene

Genomics for TAS2R10 Gene

GeneHancer (GH) Regulatory Elements for TAS2R10 Gene

Promoters and enhancers for TAS2R10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I010384 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE dbSUPER 38.8 +441.5 441527 5.1 FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB ZNF662 KLRK1 GC12P010386 TAS2R19 TAS2R31 TAS2R14 TAS2R10 KLRA1P TAS2R15P MAGOHB TAS2R20
GH12I010715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 +108.9 108871 8.8 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YBX3 KLRA1P TAS2R20 TAS2R31 TAS2R43 MAGOHB TAS2R14 TAS2R50 TAS2R15P TAS2R10
GH12I010211 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +615.1 615131 5.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GABARAPL1 ENSG00000255958 KLRA1P TAS2R31 TAS2R20 TAS2R19 TAS2R14 TAS2R10 KLRD1 CLEC7A
GH12I010391 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12 +434.2 434182 7.4 FOXA2 SMAD1 ARID4B SIN3A FEZF1 ATF7 RUNX3 DEK JUNB REST KLRK1 KLRA1P KLRC3 KLRC4 KLRC2 LOC101928100 TAS2R31 TAS2R20 MAGOHB TAS2R10
GH12I011169 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 -342.5 -342476 3 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B PRR4 TAS2R14 ENSG00000256712 ENSG00000275778 PRH1 PRH1-PRR4 SMIM10L1 LINC01252 TAS2R64P TAS2R15P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAS2R10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAS2R10 gene promoter:

Genomic Locations for TAS2R10 Gene

Genomic Locations for TAS2R10 Gene
chr12:10,815,851-10,828,965
(GRCh38/hg38)
Size:
13,115 bases
Orientation:
Minus strand
chr12:10,977,916-10,978,957
(GRCh37/hg19)

Genomic View for TAS2R10 Gene

Genes around TAS2R10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R10 Gene

Proteins for TAS2R10 Gene

  • Protein details for TAS2R10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW0-T2R10_HUMAN
    Recommended name:
    Taste receptor type 2 member 10
    Protein Accession:
    Q9NYW0
    Secondary Accessions:
    • Q3MIM9
    • Q6NTD9

    Protein attributes for TAS2R10 Gene

    Size:
    307 amino acids
    Molecular mass:
    35365 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R10 Gene

Post-translational modifications for TAS2R10 Gene

  • Glycosylation at posLast=9292 and posLast=158158

Other Protein References for TAS2R10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R10 Gene

Domains & Families for TAS2R10 Gene

Gene Families for TAS2R10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW0

UniProtKB/Swiss-Prot:

T2R10_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R10: view

Function for TAS2R10 Gene

Molecular function for TAS2R10 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R10: view
genes like me logo Genes that share phenotypes with TAS2R10: view

miRNA for TAS2R10 Gene

miRTarBase miRNAs that target TAS2R10

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R10 Gene

Localization for TAS2R10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
genes like me logo Genes that share ontologies with TAS2R10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R10 Gene

Pathways & Interactions for TAS2R10 Gene

genes like me logo Genes that share pathways with TAS2R10: view

Pathways by source for TAS2R10 Gene

Gene Ontology (GO) - Biological Process for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R10: view

No data available for SIGNOR curated interactions for TAS2R10 Gene

Drugs & Compounds for TAS2R10 Gene

(20) Drugs for TAS2R10 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 190
Benzoin Approved Pharma 0
Chloramphenicol Approved, Vet_approved Pharma 7
chloroquine Approved, Investigational, Vet_approved Pharma Agonist 154
Dapsone Approved, Investigational Pharma 68

(12) Additional Compounds for TAS2R10 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-alpha Thujone
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
Arborescin
Arglabin
Artemorin
genes like me logo Genes that share compounds with TAS2R10: view

Transcripts for TAS2R10 Gene

mRNA/cDNA for TAS2R10 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R10 Gene

Taste receptor, type 2, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R10 Gene

No ASD Table

Relevant External Links for TAS2R10 Gene

GeneLoc Exon Structure for
TAS2R10
ECgene alternative splicing isoforms for
TAS2R10

Expression for TAS2R10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R10 Gene

Protein differential expression in normal tissues from HIPED for TAS2R10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R10 Gene



Protein tissue co-expression partners for TAS2R10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAS2R10 Gene:

TAS2R10

SOURCE GeneReport for Unigene cluster for TAS2R10 Gene:

Hs.533756

mRNA Expression by UniProt/SwissProt for TAS2R10 Gene:

Q9NYW0-T2R10_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Evidence on tissue expression from TISSUES for TAS2R10 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TAS2R10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R10 Gene

Orthologs for TAS2R10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R10 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia TAS2R10 33 34
  • 84.16 (n)
cow
(Bos Taurus)
Mammalia TAS2R10 33 34
  • 77.67 (n)
T2R10C 34
  • 63 (a)
OneToMany
BOTA-T2R10B 34
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tas2r114 33
  • 71.77 (n)
mouse
(Mus musculus)
Mammalia Tas2r114 33 16 34
  • 71.23 (n)
Tas2r106 34
  • 57 (a)
OneToMany
Tas2r107 34
  • 56 (a)
OneToMany
Tas2r104 34
  • 55 (a)
OneToMany
Tas2r105 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R22 34
  • 39 (a)
OneToMany
MODO-T2R28 34
  • 38 (a)
OneToMany
T2R26 34
  • 38 (a)
OneToMany
Species where no ortholog for TAS2R10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R10 Gene

ENSEMBL:
Gene Tree for TAS2R10 (if available)
TreeFam:
Gene Tree for TAS2R10 (if available)

Paralogs for TAS2R10 Gene

Pseudogenes.org Pseudogenes for TAS2R10 Gene

genes like me logo Genes that share paralogs with TAS2R10: view

Variants for TAS2R10 Gene

Sequence variations from dbSNP and Humsavar for TAS2R10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000021490 -- 10,827,617(-) A/G upstream_transcript_variant
rs1000472531 -- 10,826,874(-) T/C upstream_transcript_variant
rs1000479506 -- 10,827,969(-) C/T upstream_transcript_variant
rs1001109808 -- 10,827,109(-) G/T upstream_transcript_variant
rs1001773125 -- 10,826,180(-) T/C/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TAS2R10 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
esv3628543 CNV gain 21293372

Variation tolerance for TAS2R10 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R10 Gene

Disorders for TAS2R10 Gene

Additional Disease Information for TAS2R10

No disorders were found for TAS2R10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R10 Gene

Publications for TAS2R10 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4 58
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 58
  3. The receptors and coding logic for bitter taste. (PMID: 15759003) Mueller KL … Ryba NJ (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 58

Products for TAS2R10 Gene

Sources for TAS2R10 Gene

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