Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TAS2R1 Gene

protein-coding   GIFtS: 55
GCID: GC05M009630

Taste Receptor, Type 2, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Taste Receptor, Type 2, Member 11 2
T2R12 3 5
TRB72 3 5
Taste Receptor Family B Member 72 3
Taste Receptor Type 2 Member 12
Taste Receptor, Family B, Member 72

External Ids:    HGNC: 149091   Entrez Gene: 508342   Ensembl: ENSG000001697777   OMIM: 6047965   UniProtKB: Q9NYW73   

Export aliases for TAS2R1 gene to outside databases

Previous GC identifers: GC05M009797 GC05M009661 GC05M009681 GC05M009682 GC05M009612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TAS2R1 Gene:
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled
receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate
epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a
bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that
controls the detection of the bitter compound 6-n-propyl-2-thiouracil. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAS2R1 Gene:
TAS2R1 (taste receptor, type 2, member 1) is a protein-coding gene. Diseases associated with TAS2R1 include hypersomnia, and autistic disorder. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot: TA2R1_HUMAN, Q9NYW7
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Wiki entry for TAS2R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAS2R1 gene promoter:
         AML1a   AP-1   Lmo2   NF-E2 p45   FOXL1   AREB6   IRF-7A   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS2R1 promoter sequence
   Search Chromatin IP Primers for TAS2R1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15   Ensembl cytogenetic band:  5p15.31   HGNC cytogenetic band: 5p15

TAS2R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M009630:  view genomic region     (about GC identifiers)

Start:
9,629,109 bp from pter      End:
9,712,490 bp from pter
Size:
83,382 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TA2R1_HUMAN, Q9NYW7 (See protein sequence)
Recommended Name: Taste receptor type 2 member 1  
Size: 299 amino acids; 34333 Da
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells
can discriminate among bitter stimuli
Secondary accessions: Q646G8

Explore the universe of human proteins at neXtProt for TAS2R1: NX_Q9NYW7

Explore proteomics data for TAS2R1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn163

  • See TAS2R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062545.1  
    ENSEMBL proteins: 
     ENSP00000476190   ENSP00000475387   ENSP00000371932  
    Reactome Protein details: Q9NYW7

    TAS2R1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TAS2R1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TAS2R1
    GenScript Custom Purified and Recombinant Proteins Services for TAS2R1
    Novus Biologicals TAS2R1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAS2R1

    TAS2R1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TAS2R1
    OriGene Custom Antibody Services for TAS2R1
    Novus Biologicals TAS2R1 Antibodies
    Abcam antibodies for TAS2R1
    Cloud-Clone Corp. Antibodies for TAS2R1
    ThermoFisher Antibodies for TAS2R1
    LSBio Antibodies in human, mouse, rat for TAS2R1

    TAS2R1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAS2R1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAS2R1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAS2R1
    Cloud-Clone Corp. CLIAs for TAS2R1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TASNR: GPCR / Unclassified : Taste receptors
    TAS2R: Taste receptors / Type 2

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS2R1
    Taste 2 receptors

    1 InterPro protein domain:
     IPR007960 TAS2_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9NYW7

    ProtoNet protein and cluster: Q9NYW7

    UniProtKB/Swiss-Prot: TA2R1_HUMAN, Q9NYW7
    Similarity: Belongs to the G-protein coupled receptor T2R family


    TAS2R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TA2R1_HUMAN, Q9NYW7
    Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role
    in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate
    alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0008527taste receptor activity TAS10761934
         
    TAS2R1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAS2R1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAS2R1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAS2R1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAS2R1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAS2R1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TAS2R1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TAS2R1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAS2R1
    Predesigned siRNA for gene silencing in human, mouse, rat TAS2R1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAS2R1

    Clone
    Products:
         
    OriGene clones in human, mouse for TAS2R1 (see all 6)
    OriGene ORF clones in mouse, rat for TAS2R1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAS2R1 (NM_016945)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAS2R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAS2R1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAS2R1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TA2R1_HUMAN, Q9NYW7: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    TAS2R1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TAS2R1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    4Sweet Taste Signaling
    Bitter Taste Signaling0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TAS2R1
        Bitter Taste Signaling

    2 Reactome Pathways for TAS2R1
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for TAS2R1):
        Taste transduction


    TAS2R1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS2R1
    Interactions:

        Search GeneGlobe Interaction Network for TAS2R1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TAS2R1 (ENSP000003719324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAT3ENSP000003813394STRING: ENSP00000381339
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS10761934
    GO:0007635chemosensory behavior TAS10761934
    GO:0050909sensory perception of taste ----
    GO:0050912detection of chemical stimulus involved in sensory perception of taste TAS10761934

    TAS2R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS2R1 (TA2R1)

    Selected BitterDB Bitter Compounds for TAS2R1 (see all 27)    About this table
    CompoundSMILES CAS #
    AdhumuloneCCC(C)C(=O)C1=C(O)C(O)(CC=C(C)C)C(=O)C(CC=C(C)C)C1=O--
    AdlupuloneCC[C@H](C)C(=O)C1=C(O)C(CC=C(C)C)(CC=C(C)C)C(=O)C(=C1O)CC=C(C)C--
    amarogentinOC[C@H]1O[C@@H](O[C@@H]2OC=C3[C@@H](CCOC3=O)[C@H]2C=C)[C@H](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@@H](O)[C@@H]1O21018-84-8
    ArborescinCC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O--
    CascarillinC[C@@H]1[C@@H](C[C@]2(C)[C@H](CC[C@@H](O)[C@]2(C)O)[C@]1(C[C@@H](O)c3cocc3)C=O)OC(=O)C10118-56-6
    chloramphenicolOC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-]--
    cis-isocohumuloneCC(C)C(=O)C1=C(O)[C@](O)([C@H](CC=C(C)C)C1=O)C(=O)CC=C(C)C--
    cis-isohumuloneCC(C)CC(=O)C1=C(O)[C@](O)([C@H](CC=C(C)C)C1=O)C(=O)CC=C(C)C--
    cis-isoloadhumuloneCC[C@H](C)C(=O)C1=C(O)[C@](O)([C@H](CC=C(C)C)C1=O)C(=O)CC=C(C)C--
    CohumuloneCC(C)C(=O)C1=C(O)C(=C(O)C(O)(CC=C(C)C)C1=O)CC=C(C)C--




    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TAS2R1 gene: 
    NM_019599.2  

    Unigene Cluster for TAS2R1:

    Taste receptor, type 2, member 1
    Hs.567492  [show with all ESTs]
    Unigene Representative Sequence: NM_019599
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514078 ENST00000506620 ENST00000382492(uc003jem.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAS2R1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TAS2R1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAS2R1
    Predesigned siRNA for gene silencing in human, mouse, rat TAS2R1
    Clone
    Products:
         
    OriGene clones in human, mouse for TAS2R1 (see all 6)
    OriGene ORF clones in mouse, rat for TAS2R1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAS2R1 (NM_016945)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAS2R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAS2R1
      QuantiTect SYBR Green Assays in human, mouse, rat TAS2R1
      QuantiFast Probe-based Assays in human, mouse, rat TAS2R1

    Additional mRNA sequence: 

    BC095521.1 BC101729.1 BC101731.1 

    1 DOTS entry:

    DT.102822724 

    21 AceView cDNA sequences:

    NM_019599 BG192000 AI191595 CN839562 BX112217 CN836511 CN843110 AF009306 
    CN835918 CN835976 AI190879 CN835406 CN839536 CN839897 CN835432 AA416581 
    BG209561 BG203110 BX090205 CN836616 CN843196 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TAS2R1 expression in normal human tissues (normalized intensities)      TAS2R1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCTTCAG
    TAS2R1 Expression
    About this image


    TAS2R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
    TAS2R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS2R1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567492

    UniProtKB/Swiss-Prot: TA2R1_HUMAN, Q9NYW7
    Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and
    exclusively in gustducin-positive cells

        Custom PCR Arrays for TAS2R1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAS2R1
    QuantiTect SYBR Green Assays in human, mouse, rat TAS2R1
    QuantiFast Probe-based Assays in human, mouse, rat TAS2R1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TAS2R1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas2r1191 , 5 taste receptor, type 2, member 1191, 5 66.22(n)1
    51.69(a)1
      15 (13.02 cM)5
    572541  NM_020503.21  NP_065249.21 
     321772895 
    chicken
    (Gallus gallus)
    Aves TAS2R76
    Gallus gallus taste receptor, type 2, member 7 (TA...
    24(a)
    1 → many
    3(109476673-109477638)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Taste receptor type 2
    (see all 3)
    32(a)
    23(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343381.1(254214-512591)
    GL343391.1(165866-166828)


    ENSEMBL Gene Tree for TAS2R1 (if available)
    TreeFam Gene Tree for TAS2R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TAS2R1 gene
    TAS2R412  TAS2R52  TAS2R462  TAS2R162  TAS2R32  TAS2R432  TAS2R142  TAS2R392  
    TAS2R382  TAS2R422  TAS2R92  TAS2R42  TAS2R302  TAS2R192  TAS2R72  TAS2R202  
    TAS2R82  TAS2R102  TAS2R502  TAS2R132  TAS2R402  TAS2R602  TAS2R312  
    Selected SIMAP similar genes for TAS2R1 using alignment to 4 protein entries:     TA2R1_HUMAN (see all proteins) (see all similar genes):
    Hosa(Biaka)-T2R1    Hosa(Japanese)-T2R1    Hosa(Biaka)-T2R55    TAS2R42    Hosa(Biaka)-T2R13    Hosa(Japanese)-T2R13
    Hosa(Japanese)-T2R39    TAS2R39    TAS2R7    TAS2R13    Hosa(Adygei)-T2R7    Hosa(Biaka)-T2R2
    Hosa(Biaka)-T2R40    Hosa(Biaka)-T2R7    TAS2R40    Hosa(Japanese)-T2R40    TAS2R10    Hosa(Adygei)-T2R55

    TAS2R1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TAS2R1 (see all 117)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432741511,2
    --9628660(+) AGAAGG/TCCTGC 1 -- ds50010--------
    rs1512550661,2
    --9628696(+) AGGAGA/GAAGAA 1 -- ds50010--------
    rs1817602031,2
    --9628858(+) CATCAC/TGAGTT 1 -- ds50010--------
    rs1155598481,2
    C,F--9628994(+) TTGCAC/AGATGA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1862772211,2
    --9629024(+) GGATAC/TTGAAA 1 -- ds50010--------
    rs1172325051,2
    C,F--9629126(+) AAACAG/AGCCTG 1 -- ut311Minor allele frequency- A:0.05EA 120
    rs1889315081,2
    --9629169(+) GCTTTA/G/TTCTGG 2 -- ut310--------
    rs1816799931,2
    C--9629223(+) GTTCTC/TTGAAC 1 -- ut310--------
    rs1404426511,2
    C--9629253(+) CTGACA/TGCACT 2 S C mis10--------
    rs22342351,2
    C,F,O,H--9629295(-) CTAAAT/CTGAAA 2 /L syn116Minor allele frequency- C:0.03NS EA NA EU 7933

    HapMap Linkage Disequilibrium report for TAS2R1 (9629109 - 9712490 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TAS2R1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv881438CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAS2R1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS2R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604796    OMIM disorders: --

    4 diseases for TAS2R1:    About MalaCards
    hypersomnia    autistic disorder    pulmonary function    asthma

    1 disease from the University of Copenhagen DISEASES database for TAS2R1:
    Autistic disorder

    TAS2R1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAS2R1
    Human Genome Epidemiology (HuGE) Navigator: TAS2R1 (2 documents)

    Export disorders for TAS2R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TAS2R1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with TAS2R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (Cell 2000)
    2. A genome-wide linkage and association scan reveals novel loci for autism. (PubMed id 19812673)1, 4 Weiss L.A....Chakravarti A. (Nature 2009)
    3. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (Mol. Biol. Evol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (Cell 2003)
    6. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (Curr. Opin. Neurobiol. 2002)
    7. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (J. Biol. Chem. 2002)
    8. T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (Cell 2000)
    9. A family of candidate taste receptors in human and mouse. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (Nature 2000)
    10. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. (PubMed id 23646285)1 Khor S.S....Tokunaga K. (PeerJ 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 50834 HGNC: 14909 AceView: TAS2R1 Ensembl:ENSG00000169777 euGenes: HUgn50834
    ECgene: TAS2R1 Kegg: 50834 H-InvDB: TAS2R1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TAS2R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAS2R1 gene:
    Search GeneIP for patents involving TAS2R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TAS2R1   OriGene RNAi products in human, mouse, rat for TAS2R1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TAS2R1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAS2R1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAS2R1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAS2R1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAS2R1   OriGene Custom Protein Services for TAS2R1  

     
     
     Block miRNA regulation of human, mouse, rat TAS2R1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TAS2R1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS2R1 Predesigned siRNA for gene silencing in human, mouse, rat TAS2R1
     QuantiFast Probe-based Assays in human, mouse, rat TAS2R1 QuantiTect SYBR Green Assays in human, mouse, rat TAS2R1
     Custom PCR Arrays for TAS2R1 Search Chromatin IP Primers for TAS2R1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAS2R1  Search GeneGlobe Interaction Network for TAS2R1
     Regulatory tfbs in TAS2R1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TAS2R1 GenScript cDNA clones with any tag delivered in your preferred vector for TAS2R1
     GenScript Custom Assay Services for TAS2R1 GenScript Custom overexpressing Cell Line Services for TAS2R1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TAS2R1 (TA2R1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TAS2R1 antibodies
     TAS2R1 lysates
     Antibodies for TAS2R1
     See all of Abcam's Antibodies, Kits and Proteins for TAS2R1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TAS2R1
     Antibodies for TAS2R1
     ELISAs for TAS2R1
     CLIAs for TAS2R1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TAS2R1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS2R1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TAS2R1
     SwitchGear Promoter luciferase reporter plasmids for TAS2R1
     ThermoFisher Antibodies for TAS2R1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS2R1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAS2R1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAS2R1
     LSBio Antibodies in human, mouse, rat for TAS2R1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAS2R1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4