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Aliases for TAS2R1 Gene

Aliases for TAS2R1 Gene

  • Taste 2 Receptor Member 1 2 3 5
  • Taste Receptor, Type 2, Member 1 2 3
  • Taste Receptor Family B Member 7 3 4
  • T2R1 3 4
  • TRB7 3 4
  • Taste Receptor, Family B, Member 7 3

External Ids for TAS2R1 Gene

Previous GeneCards Identifiers for TAS2R1 Gene

  • GC05M009797
  • GC05M009661
  • GC05M009681
  • GC05M009682
  • GC05M009612

Summaries for TAS2R1 Gene

Entrez Gene Summary for TAS2R1 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R1 Gene

TAS2R1 (Taste 2 Receptor Member 1) is a Protein Coding gene. Diseases associated with TAS2R1 include hypersomnia. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R1 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R1 Gene

Genomics for TAS2R1 Gene

Regulatory Elements for TAS2R1 Gene

Genomic Location for TAS2R1 Gene

Chromosome:
5
Start:
9,628,997 bp from pter
End:
9,712,378 bp from pter
Size:
83,382 bases
Orientation:
Minus strand

Genomic View for TAS2R1 Gene

Genes around TAS2R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R1 Gene

Proteins for TAS2R1 Gene

  • Protein details for TAS2R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW7-TA2R1_HUMAN
    Recommended name:
    Taste receptor type 2 member 1
    Protein Accession:
    Q9NYW7
    Secondary Accessions:
    • Q646G8

    Protein attributes for TAS2R1 Gene

    Size:
    299 amino acids
    Molecular mass:
    34333 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R1 Gene

Proteomics data for TAS2R1 Gene at MOPED

Post-translational modifications for TAS2R1 Gene

  • Glycosylation at Asn 163
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAS2R1 Gene

Domains & Families for TAS2R1 Gene

Gene Families for TAS2R1 Gene

Protein Domains for TAS2R1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW7

UniProtKB/Swiss-Prot:

TA2R1_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R1: view

Function for TAS2R1 Gene

Molecular function for TAS2R1 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008527 taste receptor activity TAS 10761934
genes like me logo Genes that share ontologies with TAS2R1: view
genes like me logo Genes that share phenotypes with TAS2R1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TAS2R1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R1 Gene

Localization for TAS2R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R1 Gene COMPARTMENTS Subcellular localization image for TAS2R1 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TAS2R1 Gene

Pathways & Interactions for TAS2R1 Gene

genes like me logo Genes that share pathways with TAS2R1: view

Pathways by source for TAS2R1 Gene

1 Qiagen pathway for TAS2R1 Gene

Interacting Proteins for TAS2R1 Gene

Gene Ontology (GO) - Biological Process for TAS2R1 Gene

None

No data available for SIGNOR curated interactions for TAS2R1 Gene

Drugs & Compounds for TAS2R1 Gene

(7) Drugs for TAS2R1 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma 6
Dextromethorphan Approved Pharma 122
Diphenidol Approved, Withdrawn Pharma 1
Yohimbine Approved Pharma Antagonist 25
Thiamine Approved Nutra 88,88

(20) Additional Compounds for TAS2R1 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adhumulone
28374-89-2
Adlupulone
28374-71-2
amarogentin
21018-84-8
Arborescin
Cascarillin
  • Cascarillin
10118-56-6
genes like me logo Genes that share compounds with TAS2R1: view

Transcripts for TAS2R1 Gene

mRNA/cDNA for TAS2R1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R1 Gene

Taste receptor, type 2, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R1 Gene

No ASD Table

Relevant External Links for TAS2R1 Gene

GeneLoc Exon Structure for
TAS2R1
ECgene alternative splicing isoforms for
TAS2R1

Expression for TAS2R1 Gene

mRNA expression in normal human tissues for TAS2R1 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R1 Gene

This gene is overexpressed in Testis (x17.3), Brain - Putamen (basal ganglia) (x7.2), and Brain - Caudate (basal ganglia) (x6.0).

Protein differential expression in normal tissues from HIPED for TAS2R1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R1 Gene



SOURCE GeneReport for Unigene cluster for TAS2R1 Gene Hs.567492

mRNA Expression by UniProt/SwissProt for TAS2R1 Gene

Q9NYW7-TA2R1_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R1: view

Protein tissue co-expression partners for TAS2R1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TAS2R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAS2R1 35
  • 70.17 (n)
  • 52.54 (a)
TAS2R1 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R1 35
  • 74.19 (n)
  • 58.25 (a)
TAS2R1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r119 35
  • 66.22 (n)
  • 51.69 (a)
Tas2r119 16
Tas2r119 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAS2R1 35
  • 99.22 (n)
  • 98.32 (a)
TAS2R1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r119 35
  • 66.44 (n)
  • 51.52 (a)
oppossum
(Monodelphis domestica)
Mammalia T2R1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS2R1 36
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS2R7 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
Species with no ortholog for TAS2R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R1 Gene

ENSEMBL:
Gene Tree for TAS2R1 (if available)
TreeFam:
Gene Tree for TAS2R1 (if available)

Paralogs for TAS2R1 Gene

genes like me logo Genes that share paralogs with TAS2R1: view

Variants for TAS2R1 Gene

Sequence variations from dbSNP and Humsavar for TAS2R1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs41469 - 9,629,701(-) CGTCC(A/G)TCACC reference, missense
rs2234233 - 9,629,417(-) ACACC(C/T)GGCAA reference, missense
rs2234232 - 9,629,611(-) GATTT(A/G)TGTTT reference, missense
rs41470 -- 9,630,075(-) ACTTT(A/G)TAACT utr-variant-5-prime
rs2234228 -- 9,630,403(-) TATTC(A/G)TAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS2R1 Gene

Variant ID Type Subtype PubMed ID
nsv881438 CNV Gain 21882294

Variation tolerance for TAS2R1 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R1 Gene

HapMap Linkage Disequilibrium report
TAS2R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R1 Gene

Disorders for TAS2R1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAS2R1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypersomnia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TAS2R1

Genetic Association Database (GAD)
TAS2R1
Human Genome Epidemiology (HuGE) Navigator
TAS2R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R1
genes like me logo Genes that share disorders with TAS2R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS2R1 Gene

Publications for TAS2R1 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4 67
  2. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  3. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. (PMID: 23646285) Khor S.S. … Tokunaga K. (PeerJ 2013) 3
  4. TAS2R activation promotes airway smooth muscle relaxation despite I^(2)-adrenergic receptor tachyphylaxis. (PMID: 22683571) An S.S. … Liggett S.B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012) 3
  5. Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies. (PMID: 21619450) Dai W. … Hu Y. (J. Recept. Signal Transduct. Res. 2011) 3

Products for TAS2R1 Gene

Sources for TAS2R1 Gene

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