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Aliases for TAS2R1 Gene

Aliases for TAS2R1 Gene

  • Taste Receptor, Type 2, Member 1 2 3
  • T2R1 3 4 6
  • TRB7 3 4 6
  • Taste Receptor Family B Member 7 3 4
  • Taste Receptor, Family B, Member 7 3
  • Taste Receptor Type 2 Member 1 3

External Ids for TAS2R1 Gene

Previous GeneCards Identifiers for TAS2R1 Gene

  • GC05M009797
  • GC05M009661
  • GC05M009681
  • GC05M009682
  • GC05M009612

Summaries for TAS2R1 Gene

Entrez Gene Summary for TAS2R1 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R1 Gene

TAS2R1 (Taste Receptor, Type 2, Member 1) is a Protein Coding gene. Diseases associated with TAS2R1 include hypersomnia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R1 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Wiki entry for TAS2R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R1 Gene

Genomics for TAS2R1 Gene

Regulatory Elements for TAS2R1 Gene

Genomic Location for TAS2R1 Gene

Start:
9,628,997 bp from pter
End:
9,712,378 bp from pter
Size:
83,382 bases
Orientation:
Minus strand

Genomic View for TAS2R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R1 Gene

Proteins for TAS2R1 Gene

  • Protein details for TAS2R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW7-TA2R1_HUMAN
    Recommended name:
    Taste receptor type 2 member 1
    Protein Accession:
    Q9NYW7
    Secondary Accessions:
    • Q646G8

    Protein attributes for TAS2R1 Gene

    Size:
    299 amino acids
    Molecular mass:
    34333 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R1 Gene

Proteomics data for TAS2R1 Gene at MOPED

Post-translational modifications for TAS2R1 Gene

  • Glycosylation at Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R1 Gene

Domains for TAS2R1 Gene

Gene Families for TAS2R1 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW7

UniProtKB/Swiss-Prot:

TA2R1_HUMAN :
  • Q9NYW7
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R1: view

Function for TAS2R1 Gene

Molecular function for TAS2R1 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Ontology (GO) - Molecular Function for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R1: view

Phenotypes for TAS2R1 Gene

genes like me logo Genes that share phenotypes with TAS2R1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS2R1 Gene

Localization for TAS2R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R1 Gene COMPARTMENTS Subcellular localization image for TAS2R1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R1: view

Pathways for TAS2R1 Gene

genes like me logo Genes that share pathways with TAS2R1: view

Pathways by source for TAS2R1 Gene

1 KEGG pathway for TAS2R1 Gene

Interacting Proteins for TAS2R1 Gene

Gene Ontology (GO) - Biological Process for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007635 chemosensory behavior TAS 10761934
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R1: view

Compounds for TAS2R1 Gene

(27) BitterDB Compounds for TAS2R1 Gene

Compound Smiles Cas Number
Adhumulone CCC(C)C(=O)C1=C(O)C(O)(CC=C(C)C)C(=O)C(CC=C(C)C)C1=O
Adlupulone CC[C](C)C(=O)C1=C(O)C(CC=C(C)C)(CC=C(C)C)C(=O)C(=C1O)CC=C(C)C
amarogentin OC[C]1O[C@](O[C@]2OC=C3[C@](CCOC3=O)[C]2C=C)[C](OC(=O)c4c(O)cc(O)cc4c5cccc(O)c5)[C@](O)[C@]1O 21018-84-8
Arborescin CC1C2CCC3(C)OC34CC=C(C)C4C2OC1=O
Cascarillin C[C@]1[C@](C[C@]2(C)[C](CC[C@](O)[C@]2(C)O)[C@]1(C[C@](O)c3cocc3)C=O)OC(=O)C 10118-56-6
chloramphenicol OC[C@](NC(=O)C(Cl)Cl)[C](O)c1ccc(cc1)[N+](=O)[O-]
cis-isocohumulone CC(C)C(=O)C1=C(O)[C@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
cis-isohumulone CC(C)CC(=O)C1=C(O)[C@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
cis-isoloadhumulone CC[C](C)C(=O)C1=C(O)[C@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
Cohumulone CC(C)C(=O)C1=C(O)C(=C(O)C(O)(CC=C(C)C)C1=O)CC=C(C)C
Colupulone CC(C)C(=O)C1=C(O)C(=C(O)C(CC=C(C)C)(CC=C(C)C)C1=O)CC=C(C)C
dextromethorphan COc1ccc2C[C@]3[C]4CCCC[C@]4(CCN3C)c2c1
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
diphenylthiourea,sulfocarbanilide,sym-Diphenylthiourea,thiocarbanilide S=C(Nc1ccccc1)Nc2ccccc2 102-08-9
Humulon,Humulone CC(C)CC(=O)C1=C(O)C(=C(O)[C@@](O)(CC=C(C)C)C1=O)CC=C(C)C 26472-41-3
Isoxanthohumol COc1cc(O)c(CC=C(C)C)c2OC(CC(=O)c12)c3ccc(O)cc3
Lupulon,Lupulone CC(C)CC(=O)C1=C(O)C(=C(O)C(CC=C(C)C)(CC=C(C)C)C1=O)CC=C(C)C 468-28-0
Parthenolide CC1=C/CC[C@@]2(C)O[C]2[C]3OC(=O)C(=C)[C@]3CC1
Picrotoxinin CC(=C)[C@]1[C]2OC(=O)[C@]1[C@]3(O)C[C]4O[C@]45C(=O)O[C]2[C@]35C 17617-45-7
sodium cyclamate [Na+].[O-]S(=O)(=O)NC1CCCCC1
sodium_thiocyanate [Na+].[S-][11C]#N
Thiamine Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1
trans-isoadhumulone CC[C](C)C(=O)C1=C(O)[C@@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
trans-isocohumulone CC(C)C(=O)C1=C(O)[C@@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
trans-isohumulone CC(C)CC(=O)C1=C(O)[C@@](O)([C](CC=C(C)C)C1=O)C(=O)CC=C(C)C
Xanthohumol COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)C=Cc2ccc(O)cc2
yohimbine COC(=O)[C]1[C@](O)CC[C]2CN3CCc4c([nH]c5ccccc45)[C@]3C[C]12
genes like me logo Genes that share compounds with TAS2R1: view

Transcripts for TAS2R1 Gene

mRNA/cDNA for TAS2R1 Gene

(21) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R1 Gene

Taste receptor, type 2, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAS2R1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R1 Gene

No ASD Table

Relevant External Links for TAS2R1 Gene

GeneLoc Exon Structure for
TAS2R1
ECgene alternative splicing isoforms for
TAS2R1

Expression for TAS2R1 Gene

mRNA expression in normal human tissues for TAS2R1 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R1 Gene

This gene is overexpressed in Testis (17.3), Brain - Putamen (basal ganglia) (7.2), and Brain - Caudate (basal ganglia) (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAS2R1 Gene

SOURCE GeneReport for Unigene cluster for TAS2R1 Gene Hs.567492

mRNA Expression by UniProt/SwissProt for TAS2R1 Gene

Q9NYW7-TA2R1_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R1: view

In Situ Assay Products

Orthologs for TAS2R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R1 35
  • 99.22 (n)
  • 98.32 (a)
TAS2R1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R1 35
  • 70.17 (n)
  • 52.54 (a)
TAS2R1 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R1 35
  • 74.19 (n)
  • 58.25 (a)
TAS2R1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r119 35
  • 66.22 (n)
  • 51.69 (a)
Tas2r119 16
Tas2r119 36
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia T2R1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS2R1 36
  • 30 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas2r119 35
  • 66.44 (n)
  • 51.52 (a)
chicken
(Gallus gallus)
Aves TAS2R7 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
Species with no ortholog for TAS2R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R1 Gene

ENSEMBL:
Gene Tree for TAS2R1 (if available)
TreeFam:
Gene Tree for TAS2R1 (if available)

Paralogs for TAS2R1 Gene

genes like me logo Genes that share paralogs with TAS2R1: view

Variants for TAS2R1 Gene

Sequence variations from dbSNP and Humsavar for TAS2R1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs41469 - 9,629,701(-) CGTCC(A/G)TCACC missense, reference
rs41470 -- 9,630,075(-) ACTTT(A/G)TAACT utr-variant-5-prime
rs2234228 -- 9,630,403(-) TATTC(A/G)TAGTA upstream-variant-2KB
rs2234229 -- 9,630,104(-) AAGAG(C/T)GTGAA utr-variant-5-prime
rs2234230 -- 9,630,095(-) AACAA(A/C)CCAAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TAS2R1 Gene

Variant ID Type Subtype PubMed ID
nsv881438 CNV Gain 21882294

Relevant External Links for TAS2R1 Gene

HapMap Linkage Disequilibrium report
TAS2R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R1 Gene

Disorders for TAS2R1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TAS2R1 Gene including...

Search for TAS2R1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TAS2R1 Gene

Relevant External Links for TAS2R1

Genetic Association Database (GAD)
TAS2R1
Human Genome Epidemiology (HuGE) Navigator
TAS2R1
genes like me logo Genes that share disorders with TAS2R1: view

No data available for UniProtKB/Swiss-Prot for TAS2R1 Gene

Publications for TAS2R1 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R1 Gene

Sources for TAS2R1 Gene

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