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Aliases for TAS2R1 Gene

Aliases for TAS2R1 Gene

  • Taste 2 Receptor Member 1 2 3 5
  • Taste Receptor, Type 2, Member 1 2 3
  • T2R1 3 4
  • TRB7 3 4
  • Taste Receptor, Family B, Member 7 3
  • Taste Receptor Family B Member 7 4
  • Taste Receptor Type 2 Member 1 3

External Ids for TAS2R1 Gene

Previous GeneCards Identifiers for TAS2R1 Gene

  • GC05M009797
  • GC05M009661
  • GC05M009681
  • GC05M009682
  • GC05M009612

Summaries for TAS2R1 Gene

Entrez Gene Summary for TAS2R1 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R1 Gene

TAS2R1 (Taste 2 Receptor Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R3.

UniProtKB/Swiss-Prot for TAS2R1 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R1 Gene

Genomics for TAS2R1 Gene

Regulatory Elements for TAS2R1 Gene

Enhancers for TAS2R1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G009888 0.8 FANTOM5 ENCODE 1.8 -176.3 -176344 0.3 BHLHE40 SMC3 FOS TAS2R1 GC05P009896 GC05M009872
GH05G009712 0.6 ENCODE 0.7 -0.9 -908 2.4 ZNF687 BHLHE40 SIN3A REST MNT RAD21 SMC3 FOS TAS2R1 GC05P009724
GH05G009715 0.5 ENCODE 0.7 -4.0 -4014 2.6 ZNF263 BHLHE40 FOS SPI1 TAS2R1 GC05P009724
GH05G009698 0.4 ENCODE 0.4 +13.7 13721 0.5 BHLHE40 SCRT2 GC05M009684 GC05M009685 TAS2R1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R1 Gene

Chromosome:
5
Start:
9,628,997 bp from pter
End:
9,712,378 bp from pter
Size:
83,382 bases
Orientation:
Minus strand

Genomic View for TAS2R1 Gene

Genes around TAS2R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R1 Gene

Proteins for TAS2R1 Gene

  • Protein details for TAS2R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW7-TA2R1_HUMAN
    Recommended name:
    Taste receptor type 2 member 1
    Protein Accession:
    Q9NYW7
    Secondary Accessions:
    • Q646G8

    Protein attributes for TAS2R1 Gene

    Size:
    299 amino acids
    Molecular mass:
    34333 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R1 Gene

Post-translational modifications for TAS2R1 Gene

  • Glycosylation at posLast=163163
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R1 Gene

Domains & Families for TAS2R1 Gene

Gene Families for TAS2R1 Gene

Protein Domains for TAS2R1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW7

UniProtKB/Swiss-Prot:

TA2R1_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R1: view

Function for TAS2R1 Gene

Molecular function for TAS2R1 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R1: view
genes like me logo Genes that share phenotypes with TAS2R1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TAS2R1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R1 Gene

Localization for TAS2R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC,IEA 20022913
genes like me logo Genes that share ontologies with TAS2R1: view

Pathways & Interactions for TAS2R1 Gene

genes like me logo Genes that share pathways with TAS2R1: view

Pathways by source for TAS2R1 Gene

Gene Ontology (GO) - Biological Process for TAS2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007635 chemosensory behavior TAS 10761934
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with TAS2R1: view

No data available for SIGNOR curated interactions for TAS2R1 Gene

Drugs & Compounds for TAS2R1 Gene

(7) Drugs for TAS2R1 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved, Vet_approved Pharma 7
Dextromethorphan Approved Pharma 133
Diphenidol Approved, Withdrawn Pharma 1
Yohimbine Approved, Vet_approved Pharma Antagonist 28
Thiamine Approved, Vet_approved Nutra 101,101

(20) Additional Compounds for TAS2R1 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adhumulone
28374-89-2
Adlupulone
28374-71-2
amarogentin
21018-84-8
Arborescin
Cascarillin
  • Cascarillin
10118-56-6
genes like me logo Genes that share compounds with TAS2R1: view

Transcripts for TAS2R1 Gene

mRNA/cDNA for TAS2R1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R1 Gene

Taste receptor, type 2, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R1 Gene

No ASD Table

Relevant External Links for TAS2R1 Gene

GeneLoc Exon Structure for
TAS2R1
ECgene alternative splicing isoforms for
TAS2R1

Expression for TAS2R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R1 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R1 Gene

This gene is overexpressed in Testis (x17.3), Brain - Putamen (basal ganglia) (x7.2), and Brain - Caudate (basal ganglia) (x6.0).

Protein differential expression in normal tissues from HIPED for TAS2R1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R1 Gene



Protein tissue co-expression partners for TAS2R1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAS2R1 Gene:

TAS2R1

SOURCE GeneReport for Unigene cluster for TAS2R1 Gene:

Hs.567492

mRNA Expression by UniProt/SwissProt for TAS2R1 Gene:

Q9NYW7-TA2R1_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Evidence on tissue expression from TISSUES for TAS2R1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TAS2R1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R1 Gene

Orthologs for TAS2R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R1 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia TAS2R1 34 35
  • 74.19 (n)
cow
(Bos Taurus)
Mammalia TAS2R1 34 35
  • 70.17 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r119 34
  • 66.44 (n)
mouse
(Mus musculus)
Mammalia Tas2r119 34 16 35
  • 66.22 (n)
oppossum
(Monodelphis domestica)
Mammalia T2R1 35
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS2R1 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS2R7 35
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
-- 35
  • 20 (a)
OneToMany
Species where no ortholog for TAS2R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R1 Gene

ENSEMBL:
Gene Tree for TAS2R1 (if available)
TreeFam:
Gene Tree for TAS2R1 (if available)

Paralogs for TAS2R1 Gene

genes like me logo Genes that share paralogs with TAS2R1: view

Variants for TAS2R1 Gene

Sequence variations from dbSNP and Humsavar for TAS2R1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000618526 -- 9,630,365(+) CCATA(A/G)TAATT upstream-variant-2KB
rs1001054407 -- 9,630,780(+) TCTTA(G/T)TTTTC upstream-variant-2KB
rs1001488488 -- 9,631,852(+) ACTCA(C/T)TCTGT upstream-variant-2KB
rs1002439312 -- 9,630,217(+) TGAGA(C/G)AGTCA utr-variant-5-prime
rs1002455236 -- 9,629,977(+) TCCCA(A/G)GAAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R1 Gene

Variant ID Type Subtype PubMed ID
nsv1032672 CNV gain 25217958
nsv597071 CNV gain 21841781

Variation tolerance for TAS2R1 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R1 Gene

Disorders for TAS2R1 Gene

Relevant External Links for TAS2R1

Genetic Association Database (GAD)
TAS2R1
Human Genome Epidemiology (HuGE) Navigator
TAS2R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R1

No disorders were found for TAS2R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R1 Gene

Publications for TAS2R1 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4 64
  2. A genome-wide linkage and association scan reveals novel loci for autism. (PMID: 19812673) Weiss L.A. … Chakravarti A. (Nature 2009) 3 46 64
  3. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4 64

Products for TAS2R1 Gene

Sources for TAS2R1 Gene

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