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Aliases for TAS1R3 Gene

Aliases for TAS1R3 Gene

  • Taste 1 Receptor Member 3 2 3 5
  • Taste Receptor, Type 1, Member 3 2 3
  • Sweet Taste Receptor T1R3 3 4
  • T1R3 3 4
  • TR3 4

External Ids for TAS1R3 Gene

Previous GeneCards Identifiers for TAS1R3 Gene

  • GC01U990432
  • GC01M001017
  • GC01P9G0060
  • GC01P001305
  • GC01P001256
  • GC01P000537
  • GC01P001266

Summaries for TAS1R3 Gene

Entrez Gene Summary for TAS1R3 Gene

  • The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

GeneCards Summary for TAS1R3 Gene

TAS1R3 (Taste 1 Receptor Member 3) is a Protein Coding gene. Diseases associated with TAS1R3 include Bile Duct Carcinoma. Among its related pathways are Taste transduction and Sweet Taste Signaling. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for TAS1R3 Gene

  • Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Wiki entry for TAS1R3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R3 Gene

Genomics for TAS1R3 Gene

Regulatory Elements for TAS1R3 Gene

Enhancers for TAS1R3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAS1R3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS1R3 Gene

Chromosome:
1
Start:
1,328,999 bp from pter
End:
1,335,320 bp from pter
Size:
6,322 bases
Orientation:
Plus strand

Genomic View for TAS1R3 Gene

Genes around TAS1R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS1R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS1R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R3 Gene

Proteins for TAS1R3 Gene

  • Protein details for TAS1R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX0-TS1R3_HUMAN
    Recommended name:
    Taste receptor type 1 member 3
    Protein Accession:
    Q7RTX0
    Secondary Accessions:
    • Q5TA49
    • Q8NGW9

    Protein attributes for TAS1R3 Gene

    Size:
    852 amino acids
    Molecular mass:
    93386 Da
    Quaternary structure:
    • Forms homodimers or heterodimers with TAS1R1 and TAS1R2.

neXtProt entry for TAS1R3 Gene

Proteomics data for TAS1R3 Gene at MOPED

Post-translational modifications for TAS1R3 Gene

  • Glycosylation at Asn 85, Asn 130, Asn 264, Asn 285, Asn 380, Asn 411, Asn 432, and Asn 475

Other Protein References for TAS1R3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS1R3 Gene

Domains & Families for TAS1R3 Gene

Gene Families for TAS1R3 Gene

Protein Domains for TAS1R3 Gene

Suggested Antigen Peptide Sequences for TAS1R3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTX0

UniProtKB/Swiss-Prot:

TS1R3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R3: view

Function for TAS1R3 Gene

Molecular function for TAS1R3 Gene

UniProtKB/Swiss-Prot Function:
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
genes like me logo Genes that share phenotypes with TAS1R3: view

Animal Models for TAS1R3 Gene

MGI Knock Outs for TAS1R3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TAS1R3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAS1R3 Gene

Localization for TAS1R3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS1R3 Gene COMPARTMENTS Subcellular localization image for TAS1R3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TAS1R3 Gene

Pathways & Interactions for TAS1R3 Gene

genes like me logo Genes that share pathways with TAS1R3: view

Pathways by source for TAS1R3 Gene

Gene Ontology (GO) - Biological Process for TAS1R3 Gene

None

No data available for SIGNOR curated interactions for TAS1R3 Gene

Drugs & Compounds for TAS1R3 Gene

(1) Drugs for TAS1R3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspartame Approved Nutra 0

(1) Additional Compounds for TAS1R3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAS1R3: view

Transcripts for TAS1R3 Gene

mRNA/cDNA for TAS1R3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS1R3 Gene

Taste receptor, type 1, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R3 Gene

No ASD Table

Relevant External Links for TAS1R3 Gene

GeneLoc Exon Structure for
TAS1R3
ECgene alternative splicing isoforms for
TAS1R3

Expression for TAS1R3 Gene

mRNA expression in normal human tissues for TAS1R3 Gene

mRNA differential expression in normal tissues according to GTEx for TAS1R3 Gene

This gene is overexpressed in Spleen (x6.0).

Protein differential expression in normal tissues from HIPED for TAS1R3 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS1R3 Gene



SOURCE GeneReport for Unigene cluster for TAS1R3 Gene Hs.74375

genes like me logo Genes that share expression patterns with TAS1R3: view

Protein tissue co-expression partners for TAS1R3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TAS1R3 Gene

Orthologs for TAS1R3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TAS1R3 35
  • 80.75 (n)
  • 77.59 (a)
TAS1R3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas1r3 35
  • 74.95 (n)
  • 73.61 (a)
Tas1r3 16
Tas1r3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAS1R3 35
  • 99.02 (n)
  • 99.06 (a)
TAS1R3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas1r3 35
  • 75.58 (n)
  • 74.2 (a)
oppossum
(Monodelphis domestica)
Mammalia TAS1R3 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS1R3 35
  • 54 (n)
  • 43.7 (a)
TAS1R3 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAS1R3 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r3 35
  • 50.42 (n)
  • 38.58 (a)
tas1r3 36
  • 36 (a)
OneToOne
Species with no ortholog for TAS1R3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R3 Gene

ENSEMBL:
Gene Tree for TAS1R3 (if available)
TreeFam:
Gene Tree for TAS1R3 (if available)

Paralogs for TAS1R3 Gene

Paralogs for TAS1R3 Gene

(5) SIMAP similar genes for TAS1R3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAS1R3: view

Variants for TAS1R3 Gene

Sequence variations from dbSNP and Humsavar for TAS1R3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs307377 - 1,334,174(+) CGGGC(A/C/T)GCTAC reference, missense
rs307355 -- 1,329,774(+) CCATG(C/T)GCTTT upstream-variant-2KB, utr-variant-5-prime
rs307375 -- 1,334,541(+) TGTCT(C/T)GCTAC downstream-variant-500B, utr-variant-3-prime
rs307376 -- 1,334,500(+) CCAGA(C/T)TTAGC downstream-variant-500B, utr-variant-3-prime
rs307378 -- 1,333,467(+) CAGGG(A/G/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAS1R3 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv870491 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
dgv39n71 CNV Loss 21882294

Variation tolerance for TAS1R3 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS1R3 Gene

Human Gene Mutation Database (HGMD)
TAS1R3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R3 Gene

Disorders for TAS1R3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAS1R3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bile duct carcinoma
  • carcinoma of extrahepatic bile duct
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TAS1R3

Genetic Association Database (GAD)
TAS1R3
Human Genome Epidemiology (HuGE) Navigator
TAS1R3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS1R3
genes like me logo Genes that share disorders with TAS1R3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS1R3 Gene

Publications for TAS1R3 Gene

  1. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. (PMID: 19559618) Fushan A.A. … Drayna D. (Curr. Biol. 2009) 3 23 48 67
  2. Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. (PMID: 20302879) Assadi-Porter F.M. … Max M. (J. Mol. Biol. 2010) 3 23
  3. The receptor basis of sweet taste in mammals. (PMID: 19083128) Vigues S. … Munger S.D. (Results Probl Cell Differ 2009) 3 23
  4. Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate. (PMID: 19571223) Raliou M. … Faurion A. (Am. J. Clin. Nutr. 2009) 3 23
  5. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. (PMID: 19587085) Chen Q.Y. … Breslin P.A. (Am. J. Clin. Nutr. 2009) 3 23

Products for TAS1R3 Gene

Sources for TAS1R3 Gene

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