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Aliases for TAS1R3 Gene

Aliases for TAS1R3 Gene

  • Taste Receptor, Type 1, Member 3 2 3
  • T1R3 3 4 6
  • Sweet Taste Receptor T1R3 3 4
  • Taste Receptor Type 1 Member 3 3
  • TR3 4

External Ids for TAS1R3 Gene

Previous GeneCards Identifiers for TAS1R3 Gene

  • GC01U990432
  • GC01M001017
  • GC01P9G0060
  • GC01P001305
  • GC01P001256
  • GC01P000537
  • GC01P001266

Summaries for TAS1R3 Gene

Entrez Gene Summary for TAS1R3 Gene

  • The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]

GeneCards Summary for TAS1R3 Gene

TAS1R3 (Taste Receptor, Type 1, Member 3) is a Protein Coding gene. Diseases associated with TAS1R3 include bile duct carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and sweet taste receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for TAS1R3 Gene

  • Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Wiki entry for TAS1R3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R3 Gene

Genomics for TAS1R3 Gene

Regulatory Elements for TAS1R3 Gene

Genomic Location for TAS1R3 Gene

Start:
1,330,852 bp from pter
End:
1,335,306 bp from pter
Size:
4,455 bases
Orientation:
Plus strand

Genomic View for TAS1R3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS1R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R3 Gene

Proteins for TAS1R3 Gene

  • Protein details for TAS1R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX0-TS1R3_HUMAN
    Recommended name:
    Taste receptor type 1 member 3
    Protein Accession:
    Q7RTX0
    Secondary Accessions:
    • Q5TA49
    • Q8NGW9

    Protein attributes for TAS1R3 Gene

    Size:
    852 amino acids
    Molecular mass:
    93386 Da
    Quaternary structure:
    • Forms homodimers or heterodimers with TAS1R1 and TAS1R2

neXtProt entry for TAS1R3 Gene

Proteomics data for TAS1R3 Gene at MOPED

Post-translational modifications for TAS1R3 Gene

  • Glycosylation at Asn85, Asn130, Asn264, Asn285, Asn380, Asn411, Asn432, and Asn475

Other Protein References for TAS1R3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS1R3 Gene

Domains for TAS1R3 Gene

Gene Families for TAS1R3 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS1R :Taste receptors / Type 1
IUPHAR :

Protein Domains for TAS1R3 Gene

Suggested Antigen Peptide Sequences for TAS1R3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTX0

UniProtKB/Swiss-Prot:

TS1R3_HUMAN :
  • Q7RTX0
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R3: view

Function for TAS1R3 Gene

Molecular function for TAS1R3 Gene

UniProtKB/Swiss-Prot Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Ontology (GO) - Molecular Function for TAS1R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding --
GO:0008527 contributes_to taste receptor activity IDA 16720576
GO:0033041 contributes_to sweet taste receptor activity IDA 16720576
GO:0046982 protein heterodimerization activity NAS 11917125
genes like me logo Genes that share ontologies with TAS1R3: view

Phenotypes for TAS1R3 Gene

genes like me logo Genes that share phenotypes with TAS1R3: view

Animal Models for TAS1R3 Gene

MGI Knock Outs for TAS1R3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS1R3 Gene

Localization for TAS1R3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS1R3 Gene COMPARTMENTS Subcellular localization image for TAS1R3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS1R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 11917125
GO:1903767 sweet taste receptor complex IDA 16720576
genes like me logo Genes that share ontologies with TAS1R3: view

Pathways for TAS1R3 Gene

genes like me logo Genes that share pathways with TAS1R3: view

Pathways by source for TAS1R3 Gene

Gene Ontology (GO) - Biological Process for TAS1R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0050916 sensory perception of sweet taste IDA 11917125
GO:0050917 sensory perception of umami taste IDA 11917125
genes like me logo Genes that share ontologies with TAS1R3: view

Compounds for TAS1R3 Gene

(1) HMDB Compounds for TAS1R3 Gene

Compound Synonyms Cas Number PubMed IDs
Aspartame
  • Aspartylphenylalanine methyl ester
22839-47-0

(1) Novoseek inferred chemical compound relationships for TAS1R3 Gene

Compound -log(P) Hits PubMed IDs
glutamate 46.2 5
genes like me logo Genes that share compounds with TAS1R3: view

Transcripts for TAS1R3 Gene

mRNA/cDNA for TAS1R3 Gene

(16) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS1R3 Gene

Taste receptor, type 1, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R3 Gene

No ASD Table

Relevant External Links for TAS1R3 Gene

GeneLoc Exon Structure for
TAS1R3
ECgene alternative splicing isoforms for
TAS1R3

Expression for TAS1R3 Gene

mRNA expression in normal human tissues for TAS1R3 Gene

mRNA differential expression in normal tissues according to GTEx for TAS1R3 Gene

This gene is overexpressed in Spleen (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAS1R3 Gene

SOURCE GeneReport for Unigene cluster for TAS1R3 Gene Hs.74375

genes like me logo Genes that share expressions with TAS1R3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TAS1R3 Gene

Orthologs for TAS1R3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS1R3 35
  • 99.02 (n)
  • 99.06 (a)
TAS1R3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS1R3 35
  • 80.75 (n)
  • 77.59 (a)
TAS1R3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas1r3 35
  • 74.95 (n)
  • 73.61 (a)
Tas1r3 16
Tas1r3 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAS1R3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas1r3 35
  • 75.58 (n)
  • 74.2 (a)
chicken
(Gallus gallus)
Aves TAS1R3 35
  • 54 (n)
  • 43.7 (a)
TAS1R3 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAS1R3 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r3 35
  • 50.42 (n)
  • 38.58 (a)
tas1r3 36
  • 36 (a)
OneToOne
Species with no ortholog for TAS1R3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R3 Gene

ENSEMBL:
Gene Tree for TAS1R3 (if available)
TreeFam:
Gene Tree for TAS1R3 (if available)

Paralogs for TAS1R3 Gene

Paralogs for TAS1R3 Gene

Selected SIMAP similar genes for TAS1R3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAS1R3: view

Variants for TAS1R3 Gene

Sequence variations from dbSNP and Humsavar for TAS1R3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs307355 -- 1,329,774(+) CCATG(C/T)GCTTT upstream-variant-2KB
rs307375 -- 1,334,541(+) TGTCT(C/T)GCTAC downstream-variant-500B
rs307376 -- 1,334,500(+) CCAGA(C/T)TTAGC downstream-variant-500B
rs307377 - 1,334,174(+) CGGGC(C/T)GCTAC downstream-variant-500B
rs307378 -- 1,333,467(+) CAGGG(G/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAS1R3 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv870491 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
dgv39n71 CNV Loss 21882294

Relevant External Links for TAS1R3 Gene

HapMap Linkage Disequilibrium report
TAS1R3
Human Gene Mutation Database (HGMD)
TAS1R3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R3 Gene

Disorders for TAS1R3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TAS1R3 Gene including...

Search for TAS1R3 Gene in MalaCards »

Relevant External Links for TAS1R3

Genetic Association Database (GAD)
TAS1R3
Human Genome Epidemiology (HuGE) Navigator
TAS1R3
genes like me logo Genes that share disorders with TAS1R3: view

No data available for UniProtKB/Swiss-Prot for TAS1R3 Gene

Publications for TAS1R3 Gene

  1. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. (PMID: 19559618) Fushan A.A. … Drayna D. (Curr. Biol. 2009) 3 23 48
  2. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. (PMID: 19587085) Chen Q.Y. … Breslin P.A. (Am. J. Clin. Nutr. 2009) 3 23 48
  3. Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. (PMID: 20302879) Assadi-Porter F.M. … Max M. (J. Mol. Biol. 2010) 3 23
  4. A candidate taste receptor gene near a sweet taste locus. (PMID: 11319557) Montmayeur J.P. … Buck L.B. (Nat. Neurosci. 2001) 2 3
  5. Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate. (PMID: 19571223) Raliou M. … Faurion A. (Am. J. Clin. Nutr. 2009) 3 23

Products for TAS1R3 Gene

  • antibodies-online peptides for TAS1R3
  • antibodies-online antibodies for TAS1R3
  • antibodies-online kits for TAS1R3

Sources for TAS1R3 Gene

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