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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAS1R3 Gene

protein-coding   GIFtS: 51
GCID: GC01P001266

taste receptor, type 1, member 3

 Explore 3 diseases affiliated with
TAS1R3 via our new
 Human Malady Compendium 
Biological research products
for TAS1R3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Taste Receptor, Type 1, Member 31 2
T1R31 2 3 5
Sweet Taste Receptor T1R32 3
Taste Receptor Type 1 Member 32
TR33

External Ids:    HGNC: 156611   Entrez Gene: 837562   Ensembl: ENSG000001699627   OMIM: 6058655   UniProtKB: Q7RTX03   

Export aliases for TAS1R3 gene to outside databases

Previous GC identifers: GC01U990432 GC01M001017 GC01P9G0060 GC01P001305 GC01P001256 GC01P000537


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS1R3:
The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and
-insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001
(PubMed 11326277)).(supplied by OMIM, Jan 2010)

UniProtKB/Swiss-Prot: TS1R3_HUMAN, Q7RTX0
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium
glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition
and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can
significantly influence the selectivity and specificity of taste responses

Gene Wiki entry for TAS1R3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS1R3 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TAS1R3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS1R3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

TAS1R3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS1R3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001266:  view genomic region     (about GC identifiers)

Start:
1,266,694 bp from pter      End:
1,270,686 bp from pter
Size:
3,993 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TS1R3_HUMAN, Q7RTX0 (See protein sequence)
Recommended Name: Taste receptor type 1 member 3 precursor  
Size: 852 amino acids; 93386 Da
Subunit: Forms homodimers or heterodimers with TAS1R1 and TAS1R2
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5TA49 Q8NGW9

Explore the universe of human proteins at neXtProt for TAS1R3: NX_Q7RTX0

TAS1R3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_689414.1  
ENSEMBL proteins: 
 ENSP00000344411  
Reactome Protein details: Q7RTX0
Human Recombinant Protein Products: 
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Uscn Proteins for TAS1R3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IC11917125


TAS1R3 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for TAS1R3


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAS1R3 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR011500 GPCR_3_9-Cys_dom
 IPR000337 GPCR_3
 IPR017978 GPCR_3_C
 IPR017979 GPCR_3_CS
 IPR001828 ANF_lig-bd_rcpt

Graphical View of Domain Structure for InterPro Entry Q7RTX0

ProtoNet protein and cluster: Q7RTX0

UniProtKB/Swiss-Prot: TS1R3_HUMAN, Q7RTX0
Similarity: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: TS1R3_HUMAN, Q7RTX0
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium
glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition
and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can
significantly influence the selectivity and specificity of taste responses

miRNA
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Inhib. RNA
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OriGene siRNA: TAS1R3
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS1R3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008527contributes to taste receptor activity IDA16720576
GO:0033041contributes to sweet taste receptor activity IDA16720576
GO:0046982protein heterodimerization activity NAS11917125


TAS1R3 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-outs for TAS1R3: Tas1r3tm1Lex Tas1r3tm1Rfm Tas1r3tm1Csz
     2 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tas1r3):
 nervous system  taste/olfaction 

TAS1R3 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
2Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)1.00
3Selected targets of C/EBPbeta
Selected targets of C/EBPbeta1.00
4Sweet Taste Signaling
Sweet Taste Signaling1.00
5Carbohydrate digestion and absorption
Carbohydrate digestion and absorption1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TAS1R3
    Selected targets of C/EBPbeta

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS1R3
    Sweet Taste Signaling

4        Reactome Pathways for TAS1R3
    Signal Transduction
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by GPCR
GPCR ligand binding


2         Kegg Pathways  (Kegg details for TAS1R3):
    Taste transduction
Carbohydrate digestion and absorption


TAS1R3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAS1R3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for TAS1R3 (Q7RTX03 ENSP000003444114) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TAS1R1Q7RTX13, ENSP000003318674I2D: score=1 STRING: ENSP00000331867
TAS1R2Q8TE233, ENSP000003645204I2D: score=1 STRING: ENSP00000364520
GNASENSP000003601414STRING: ENSP00000360141
GNAT3ENSP000003813394STRING: ENSP00000381339
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001582detection of chemical stimulus involved in sensory perception of sweet taste IDA16720576
GO:0007186G-protein coupled receptor signaling pathway IC16720576
GO:0050916sensory perception of sweet taste IDA15299024
GO:0050917sensory perception of umami taste IDA11917125


TAS1R3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TAS1R3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS1R3

1 HMDB Compound for TAS1R3    About this table
CompoundSynonyms CAS #PubMed Ids
AspartameAspartylphenylalanine methyl ester (see all 12)22839-47-0--
1 Novoseek chemical compound relationship for TAS1R3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glutamate 46.2 7 19571223 (3), 17168764 (1), 16801379 (1)

Search CenterWatch for drugs/clinical trials and news about TAS1R3 / TS1R3 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAS1R3 gene: 
NM_152228.1  

Unigene Cluster for TAS1R3:

Taste receptor, type 1, member 3
Hs.74375  [show with all ESTs]
Unigene Representative Sequence: NM_152228
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000339381(uc010nyk.2)

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Inhib. RNA
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Clone
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS1R3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS1R3

Additional cDNA sequence: AK122959.1 

8 DOTS entries:

DT.113126  DT.97777835  DT.100820977  DT.92435722  DT.100673315  DT.92435732  DT.97864251  DT.40245430 

16 AceView cDNA sequences:

BE326213 BE673958 AA610441 AI350115 BK000152 BQ953027 CB157409 CK821614 
AK122959 AI693454 BM706305 BU734688 BM990748 D25680 M91220 BF923602 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAS1R3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAGAAAAC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See TAS1R3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.74375
    SABiosciences Custom PCR Arrays for TAS1R3
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS1R3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS1R3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R3 gene from 3/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves TAS1R31 taste receptor, type 1, member 3 54.34(n)
44.23(a)
  428182  XM_425740.2  XP_425740.2 
lizard
(Anolis carolinensis)
Reptilia TAS1R36
--
(see all 3)
--
43(a)
31(a)
(see all 3)
1 ↔ 1
possible ortholog
(see all 3)
GL343760.1(84610-98520)
GL343760.1(67836-78669)
zebrafish
(Danio rerio)
Actinopterygii tas1r31 taste receptor, type 1, member 3 50.3(n)
38.42(a)
  562318  NM_001039628.1  NP_001034717.1 


ENSEMBL Gene Tree for TAS1R3 (if available)
TreeFam Gene Tree for TAS1R3 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TAS1R3 gene
TAS1R22  CASR2  TAS1R12  GPRC6A2  
5 SIMAP similar genes for TAS1R3 using alignment to 1 protein entry:     TS1R3_HUMAN:
GPCR    TAS1R1    GPRC6A    TAS1R2    CASR

TAS1R3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/32 NCBI SNPs in TAS1R3 are shown (see all 32    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1506896351,2
C--540454(+) GCAGGC/TGGCCG 2 A V mis11Minor allele frequency- T:0.00NA 3990
rs1454085401,2
C,F--540897(+) GTGTCC/TTGGGC 2 L syn11Minor allele frequency- T:0.00NA 4388
rs348108281,2
C,F,H--540928(-) AACACC/TTGGGC 2 K R mis16Minor allele frequency- T:0.01NS NA 784
rs359132531,2
C--540984(-) GCCCCC/TTCCCA 2 R G mis11Minor allele frequency- T:0.00NA 2
rs1130759771,2
--541120(+) GACCCG/ATGTCT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs3073751,2
--541126(+) TGTCTC/TGCTAC 1 -- ds5001 ese32Minor allele frequency- T:0.01MN CSA 186
rs354240021,2
C,F,H,--541189(-) GGGCTC/TACTGT 1 -- ds500116Minor allele frequency- T:0.16NS EA NA CSA 1975
rs1135342271,2
C,--541252(+) CTGTGG/TCCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs726348031,2
C,F,--541335(+) CCAGGG/ATACCC 1 -- ds50011Minor allele frequency- A:0.03NA 120
rs1479217601,2
----540493(+) GAGCTA/GGGCAG 2 * W stg10--------

HapMap Linkage Disequilibrium report for TAS1R3 (1266694 - 1270686 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TAS1R3
     3 CNVs: 0001 3275 30362
Human Gene Mutation Database (HGMD): TAS1R3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAS1R3 for disorders           About GeneDecksing

OMIM gene information: 605865    OMIM disorders: --

3 diseases for TAS1R3:    About MalaCards
bile duct carcinoma    dental caries    carcinoma

Human Genome Epidemiology (HuGE) Navigator: TAS1R3 (3 documents)

Export disorders for TAS1R3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAS1R3 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with TAS1R3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  2. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. (PubMed id 15299024)1, 2 Jiang P....Max M. (2004)
  3. Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose. (PubMed id 12892531)1, 2 Ariyasu T....Kurimoto M. (2003)
  4. Human receptors for sweet and umami taste. (PubMed id 11917125)1, 2 Li X.... Adler E. (2002)
  5. A candidate taste receptor gene near a sweet taste locus. (PubMed id 11319557)1, 3 Montmayeur J.P....Buck L.B. (2001)
  6. CCAAT/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1. (PubMed id 17928076)1, 9 Toyono T....Toyoshima K. (2007)
  7. Allelic polymorphism within the TAS1R3 promoter is as sociated with human taste sensitivity to sucrose. (PubMed id 19559618)1, 9 Fushan A.A....Drayna D. (2009)
  8. Nonsynonymous single nucleotide polymorphisms in huma n tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate. (PubMed id 19571223)1, 9 Raliou M....Faurion A. (2009)
  9. Key amino acid residues involved in multi-point bindi ng interactions between brazzein, a sweet protein, and the T1R2-T1R3 human swee t receptor. (PubMed id 20302879)1, 9 Assadi-Porter F.M....Max M. (2010)
  10. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. (PubMed id 19587085)1, 9 Chen Q.Y....Breslin P.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83756 HGNC: 15661 AceView: TAS1R3 Ensembl:ENSG00000169962 euGenes: HUgn83756
ECgene: TAS1R3 Kegg: 83756 H-InvDB: TAS1R3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TAS1R3 Pharmacogenomics, SNPs, Pathways
Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt055.shtml

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TAS1R3 gene:
Search GeneIP for patents involving TAS1R3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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