Aliases for TAS1R3 Gene
External Ids for TAS1R3 Gene
Previous GeneCards Identifiers for TAS1R3 Gene
The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]
GeneCards Summary for TAS1R3 Gene
TAS1R3 (Taste Receptor, Type 1, Member 3) is a Protein Coding gene. Diseases associated with TAS1R3 include bile duct carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and sweet taste receptor activity. An important paralog of this gene is GRM1.
UniProtKB/Swiss-Prot for TAS1R3 Gene
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.