TAS1R2 Gene
protein-coding GIFtS: 56
GCID: GC01M019166
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|
taste receptor, type 1, member 2(Previous name: G protein-coupled receptor 71 )
(Previous symbol: GPR71)
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Aliases
for TAS1R2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taste Receptor, Type 1, Member 21 2 | | G Protein-Coupled Receptor 711 2 | | T1R21 2 3 5 | | Sweet Taste Receptor T1R22 3 | | GPR711 2 3 | | G-Protein Coupled Receptor 712 3 | | TR21 2 3 | | Taste Receptor Type 1 Member 22 |
Export aliases for TAS1R2 gene to outside databasesPrevious GC identifers: GC00U990928 GC01M018208 GC01M018599 GC01M018911 GC01M019038 GC01M017412 |
Summaries
for TAS1R2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TS1R2_HUMAN, Q8TE23Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners
Gene Wiki entry for TAS1R2
|
Genomic Views
for TAS1R2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS1R2 gene promoter:
USF1 AML1a SREBP-1c HNF-4alpha2 HNF-4alpha1 SREBP-1b SREBP-1a USF-1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS1R2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAS1R2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13TAS1R2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M019166: view genomic region
(about GC identifiers)
Start:
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19,166,093 bp from pter |
End:
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19,186,176 bp from pter |
Size:
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20,084 bases |
Orientation:
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minus strand |
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Proteins
for TAS1R2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TS1R2_HUMAN, Q8TE23 (See
protein sequence)Recommended Name: Taste receptor type 1 member 2 precursor Size: 839 amino acids; 95183 Da
Subunit: Forms heterodimers with TAS1R3
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5TZ19Explore the universe of human proteins at neXtProt for TAS1R2: NX_Q8TE23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TE23
TAS1R2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689418.2
ENSEMBL proteins: ENSP00000364520 Reactome Protein details: Q8TE23
Human Recombinant Protein Products for TAS1R2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TAS1R2 for ontologies About GeneDecksing
TAS1R2 Antibody Products:
Assay Products for TAS1R2: |
Protein
Domains /
Families
for TAS1R2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS1R2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TE23ProtoNet protein and cluster: Q8TE23 1 Blocks protein family: IPB001828 Extracellular ligand-binding receptor
UniProtKB/Swiss-Prot: TS1R2_HUMAN, Q8TE23Similarity: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily |
Function
for TAS1R2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TS1R2_HUMAN, Q8TE23Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TAS1R2 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tas1r2):
TAS1R2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Tas1r2tm1Csz for TAS1R2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS1R2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS1R2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAS1R2 (NM_152232) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS1R2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS1R2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS1R2 |
|
Pathways & Interactions
for TAS1R2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Class C/3 (Metabotropic glutamate/pheromone receptors) | | | 3 | Sweet Taste Signaling | | | 4 | Carbohydrate digestion and absorption | | | 5 | Taste transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TAS1R2
4 
Reactome Pathways for TAS1R2
2 
Kegg Pathways (Kegg details for TAS1R2):
TAS1R2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS1R2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TAS1R2 (Q8TE233 ENSP000003645204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TAS1R2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS1R2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAS1R2
1 HMDB Compound for TAS1R2 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Aspartame | Aspartylphenylalanine methyl ester (see all 12) | 22839-47-0 | -- |
1 DrugBank Compound for TAS1R2 About this table
Search CenterWatch for drugs/clinical trials and news about TAS1R2 / TS1R2
|
Transcripts
for TAS1R2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAS1R2 gene: NM_152232.2 Unigene Cluster for TAS1R2: Taste receptor, type 1, member 2 Hs.553548 Unigene Representative Sequence: NM_1522321 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375371(uc001bba.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAS1R2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAS1R2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAS1R2 (NM_152232) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAS1R2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS1R2 |
2 AceView cDNA sequences: NM_152232 BK000151
GeneLoc Exon Structure
|
Expression
for TAS1R2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAS1R2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAGGGACT
About this image
See TAS1R2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAS1R2
SOURCE GeneReport for Unigene cluster: Hs.553548
SABiosciences Custom PCR Arrays for TAS1R2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAS1R2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAS1R2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAS1R2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAS1R2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS1R2 |
Orthologs
for TAS1R2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAS1R2 gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TAS1R26 |
-- |
47(a) |
1 ↔ 1 |
AAWZ02036459(14990-22806) |
zebrafish
(Danio rerio) |
Actinopterygii |
tas1r2.26tas1r2.16 |
taste receptor, type 1, member 2.1 |
32(a)32(a) |
1 ↔ many1 ↔ many |
8(48813560-48823159) 8(48741456-48751614) |
ENSEMBL Gene Tree for TAS1R2 (if available)
TreeFam Gene Tree for TAS1R2 (if available) |
Paralogs
for TAS1R2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAS1R2 gene
- CASR2 TAS1R32 TAS1R12 GPRC6A2
4 SIMAP similar genes for TAS1R2 using alignment to 1 protein entry: TS1R2_HUMAN:TAS1R1 GPRC6A TAS1R3 CASR
TAS1R2 for paralogs About GeneDecksing
|
Genomic Variants
for TAS1R2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAS1R2 (19166093 - 19186176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAS1R2: --
Human Gene Mutation Database (HGMD): TAS1R2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAS1R2 |
|
Disorders
/ Diseases
for TAS1R2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAS1R2 for disorders About GeneDecksing
OMIM gene information: 606226
OMIM disorders: --
6  diseases for TAS1R2: About MalaCardsbile duct carcinoma dental caries anorexia nervosa parkinson's disease
obesity carcinoma
1 disease from the University of Copenhagen DISEASES database for TAS1R2:Dental caries Human Genome Epidemiology (HuGE) Navigator: TAS1R2 (4 documents)
Export disorders for TAS1R2 gene to outside databases
|
Publications
for TAS1R2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAS1R2 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with TAS1R2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Human receptors for sweet and umami taste. (PubMed id 11917125)1, 2 Li X.... Adler E. (2002)
- Key amino acid residues involved in multi-point bindi ng interactions between brazzein, a sweet protein, and the T1R2-T1R3 human swee t receptor. (PubMed id 20302879)1, 9 Assadi-Porter F.M....Max M. (2010)
- Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. (PubMed id 22315413)1 Kyriazis G.A....Tyrberg B. (2012)
- The role of the gut sweet taste receptor in regulatin g GLP-1, PYY, and CCK release in humans. (PubMed id 21540445)1 Gerspach A.C....Beglinger C. (2011)
- Interactions between the human sweet-sensing T1R2-T1R 3 receptor and sweeteners detected by saturation transfer difference NMR spectr oscopy. (PubMed id 19664591)1 Assadi-Porter F.M....Max M. (2010)
- Genome-wide association study confirms SNPs in SNCA a nd the MAPT region as common risk factors for Parkinson disease. (PubMed id 20070850)1 Edwards T.L....Martin E.R. (2010)
- Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1 Pinheiro A.P....Woodside D.B. (2010)
- Positive allosteric modulators of the human sweet tas te receptor enhance sweet taste. (PubMed id 20173092)1 Servant G....Karanewsky D.S. (2010)
- Taste genes associated with dental caries. (PubMed id 20858777)1 Wendell S....Marazita M.L. (2010)
|
External Searches for TAS1R2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS1R2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS1R2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS1R2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAS1R2 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt055.shtml |
|
| | |
About This Section
| Patent Information for TAS1R2 gene:
Search GeneIP for patents involving TAS1R2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS1R2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | TAS1R2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS1R2 |
|  |  |  |  | | | | ThermoFisher Antibodies for TAS1R2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAS1R2 |
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