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Aliases for TAS1R2 Gene

Aliases for TAS1R2 Gene

  • Taste Receptor, Type 1, Member 2 2 3
  • T1R2 3 4 6
  • G Protein-Coupled Receptor 71 2 3
  • G-Protein Coupled Receptor 71 3 4
  • Sweet Taste Receptor T1R2 3 4
  • GPR71 3 4
  • TR2 3 4
  • Taste Receptor Type 1 Member 2 3

External Ids for TAS1R2 Gene

Previous HGNC Symbols for TAS1R2 Gene

  • GPR71

Previous GeneCards Identifiers for TAS1R2 Gene

  • GC00U990928
  • GC01M018208
  • GC01M018599
  • GC01M018911
  • GC01M019038
  • GC01M019166
  • GC01M017412

Summaries for TAS1R2 Gene

GeneCards Summary for TAS1R2 Gene

TAS1R2 (Taste Receptor, Type 1, Member 2) is a Protein Coding gene. Diseases associated with TAS1R2 include bile duct carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and sweet taste receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for TAS1R2 Gene

  • Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

Gene Wiki entry for TAS1R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R2 Gene

Genomics for TAS1R2 Gene

Regulatory Elements for TAS1R2 Gene

Genomic Location for TAS1R2 Gene

Start:
18,839,599 bp from pter
End:
18,859,682 bp from pter
Size:
20,084 bases
Orientation:
Minus strand

Genomic View for TAS1R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R2 Gene

Proteins for TAS1R2 Gene

  • Protein details for TAS1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE23-TS1R2_HUMAN
    Recommended name:
    Taste receptor type 1 member 2
    Protein Accession:
    Q8TE23
    Secondary Accessions:
    • Q5TZ19

    Protein attributes for TAS1R2 Gene

    Size:
    839 amino acids
    Molecular mass:
    95183 Da
    Quaternary structure:
    • Forms heterodimers with TAS1R3

neXtProt entry for TAS1R2 Gene

Proteomics data for TAS1R2 Gene at MOPED

Post-translational modifications for TAS1R2 Gene

  • Glycosylation at Asn84, Asn248, Asn292, Asn312, Asn368, Asn428, Asn487, and Asn527
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS1R2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS1R2 Gene

Domains for TAS1R2 Gene

Gene Families for TAS1R2 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS1R :Taste receptors / Type 1
IUPHAR :

Suggested Antigen Peptide Sequences for TAS1R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE23

UniProtKB/Swiss-Prot:

TS1R2_HUMAN :
  • Q8TE23
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R2: view

Function for TAS1R2 Gene

Molecular function for TAS1R2 Gene

UniProtKB/Swiss-Prot Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

Gene Ontology (GO) - Molecular Function for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding --
GO:0008527 contributes_to taste receptor activity IDA 16720576
GO:0033041 contributes_to sweet taste receptor activity IDA 16720576
GO:0046982 protein heterodimerization activity NAS 11917125
genes like me logo Genes that share ontologies with TAS1R2: view

Phenotypes for TAS1R2 Gene

genes like me logo Genes that share phenotypes with TAS1R2: view

Animal Models for TAS1R2 Gene

MGI Knock Outs for TAS1R2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS1R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS1R2 Gene

Localization for TAS1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS1R2 Gene COMPARTMENTS Subcellular localization image for TAS1R2 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 11917125
GO:0043235 receptor complex IDA 23382219
GO:1903767 sweet taste receptor complex IDA 16720576
genes like me logo Genes that share ontologies with TAS1R2: view

Pathways for TAS1R2 Gene

genes like me logo Genes that share pathways with TAS1R2: view

Pathways by source for TAS1R2 Gene

Gene Ontology (GO) - Biological Process for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050916 sensory perception of sweet taste IDA 11917125
genes like me logo Genes that share ontologies with TAS1R2: view

Compounds for TAS1R2 Gene

(1) HMDB Compounds for TAS1R2 Gene

Compound Synonyms Cas Number PubMed IDs
Aspartame
  • Aspartylphenylalanine methyl ester
22839-47-0

(1) Drugbank Compounds for TAS1R2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aspartame
  • 1-Methyl N-L-alpha-aspartyl-L-phenylalanate
22839-47-0 target agonist
genes like me logo Genes that share compounds with TAS1R2: view

Transcripts for TAS1R2 Gene

mRNA/cDNA for TAS1R2 Gene

(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS1R2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAS1R2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R2 Gene

No ASD Table

Relevant External Links for TAS1R2 Gene

GeneLoc Exon Structure for
TAS1R2
ECgene alternative splicing isoforms for
TAS1R2

Expression for TAS1R2 Gene

mRNA expression in normal human tissues for TAS1R2 Gene

SOURCE GeneReport for Unigene cluster for TAS1R2 Gene Hs.553548

genes like me logo Genes that share expressions with TAS1R2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for TAS1R2 Gene

Orthologs for TAS1R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615078 35
  • 96.86 (n)
  • 95.95 (a)
TAS1R2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS1R2 35
  • 82.4 (n)
  • 75.36 (a)
TAS1R2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS1R2 35
  • 83.21 (n)
  • 76.44 (a)
mouse
(Mus musculus)
Mammalia Tas1r2 35
  • 77.63 (n)
  • 69.85 (a)
Tas1r2 16
Tas1r2 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAS1R2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS1R2 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas1r2 35
  • 78.4 (n)
  • 71.24 (a)
lizard
(Anolis carolinensis)
Reptilia TAS1R2 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r2.1 36
  • 33 (a)
OneToMany
tas1r2.2 36
  • 33 (a)
OneToMany
Species with no ortholog for TAS1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R2 Gene

ENSEMBL:
Gene Tree for TAS1R2 (if available)
TreeFam:
Gene Tree for TAS1R2 (if available)

Paralogs for TAS1R2 Gene

Paralogs for TAS1R2 Gene

Selected SIMAP similar genes for TAS1R2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAS1R2: view

Variants for TAS1R2 Gene

Sequence variations from dbSNP and Humsavar for TAS1R2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3935570 -- 18,840,877(+) CCACT(G/T)ACTCA intron-variant
rs4073538 -- 18,845,847(-) TGCCT(G/T)GGGGG intron-variant
rs4076837 -- 18,850,249(+) GCAAG(C/T)TTCTG intron-variant
rs4076838 -- 18,850,414(+) GGAGT(C/T)GGGCC intron-variant
rs4076839 -- 18,850,447(+) TAGCA(C/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAS1R2 Gene

Variant ID Type Subtype PubMed ID
nsv870906 CNV Gain 21882294

Relevant External Links for TAS1R2 Gene

HapMap Linkage Disequilibrium report
TAS1R2
Human Gene Mutation Database (HGMD)
TAS1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R2 Gene

Disorders for TAS1R2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TAS1R2 Gene including...

Search for TAS1R2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TAS1R2 Gene

Relevant External Links for TAS1R2

Genetic Association Database (GAD)
TAS1R2
Human Genome Epidemiology (HuGE) Navigator
TAS1R2
genes like me logo Genes that share disorders with TAS1R2: view

No data available for UniProtKB/Swiss-Prot for TAS1R2 Gene

Publications for TAS1R2 Gene

  1. Human receptors for sweet and umami taste. (PMID: 11917125) Li X. … Adler E. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  4. Taste genes associated with dental caries. (PMID: 20858777) Wendell S. … Marazita M.L. (J. Dent. Res. 2010) 3 48
  5. Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. (PMID: 20943793) Eny K.M. … El-Sohemy A. (Am. J. Clin. Nutr. 2010) 3 48

Products for TAS1R2 Gene

  • antibodies-online peptides for TAS1R2
  • antibodies-online antibodies for TAS1R2
  • antibodies-online kits for TAS1R2

Sources for TAS1R2 Gene

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