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TAS1R2 Gene

protein-coding   GIFtS: 59
GCID: GC01M019166

Taste Receptor, Type 1, Member 2

(Previous name: G protein-coupled receptor 71)
(Previous symbol: GPR71)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taste Receptor, Type 1, Member 21 2     Sweet Taste Receptor T1R22 3
GPR711 2 3     TR22 3
T1R22 3 5     G-Protein Coupled Receptor 712 3
G Protein-Coupled Receptor 711 2     Taste Receptor Type 1 Member 22

External Ids:    HGNC: 149051   Entrez Gene: 808342   Ensembl: ENSG000001790027   OMIM: 6062265   UniProtKB: Q8TE233   

Export aliases for TAS1R2 gene to outside databases

Previous GC identifers: GC00U990928 GC01M018208 GC01M018599 GC01M018911 GC01M019038 GC01M017412


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAS1R2 Gene:
TAS1R2 (taste receptor, type 1, member 2) is a protein-coding gene. Diseases associated with TAS1R2 include bile duct carcinoma, and dental caries. GO annotations related to this gene include sweet taste receptor activity and protein heterodimerization activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: TS1R2_HUMAN, Q8TE23
Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

Gene Wiki entry for TAS1R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAS1R2 gene promoter:
         USF1   AML1a   SREBP-1c   HNF-4alpha2   HNF-4alpha1   SREBP-1b   SREBP-1a   USF-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAS1R2 promoter sequence
   Search Chromatin IP Primers for TAS1R2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAS1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

TAS1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS1R2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M019166:  view genomic region     (about GC identifiers)

Start:
19,166,093 bp from pter      End:
19,186,176 bp from pter
Size:
20,084 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TS1R2_HUMAN, Q8TE23 (See protein sequence)
Recommended Name: Taste receptor type 1 member 2 precursor  
Size: 839 amino acids; 95183 Da
Subunit: Forms heterodimers with TAS1R3
Secondary accessions: Q5TZ19

Explore the universe of human proteins at neXtProt for TAS1R2: NX_Q8TE23

Explore proteomics data for TAS1R2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn84, Asn248, Asn292, Asn312, Asn368, Asn428, Asn487, Asn527

  • See TAS1R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689418.2  
    ENSEMBL proteins: 
     ENSP00000364520  
    Reactome Protein details: Q8TE23

    TAS1R2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TAS1R: Taste receptors / Type 1
    TASNR: GPCR / Unclassified : Taste receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAS1R2
    Taste 1 receptors

    Selected InterPro protein domains (see all 6):
     IPR011500 GPCR_3_9-Cys_dom
     IPR028082 Peripla_BP_I
     IPR000337 GPCR_3
     IPR017978 GPCR_3_C
     IPR017979 GPCR_3_CS

    Graphical View of Domain Structure for InterPro Entry Q8TE23

    ProtoNet protein and cluster: Q8TE23

    1 Blocks protein domain: IPB001828 Extracellular ligand-binding receptor

    UniProtKB/Swiss-Prot: TS1R2_HUMAN, Q8TE23
    Similarity: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily


    TAS1R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TS1R2_HUMAN, Q8TE23
    Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding ----
    GO:0008527contributes to taste receptor activity IDA16720576
    GO:0033041contributes to sweet taste receptor activity IDA16720576
    GO:0046982protein heterodimerization activity NAS11917125
         
    TAS1R2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tas1r2):
     nervous system  taste/olfaction 

    TAS1R2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tas1r2tm1Csz for TAS1R2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAS1R2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAS1R2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAS1R2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAS1R2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TS1R2_HUMAN, Q8TE23: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IC11917125
    GO:0043235receptor complex IDA--

    TAS1R2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAS1R2 About    
    See pathways by source

    SuperPathContained pathways About
    1Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45
    Taste transduction0.45
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3Sweet Taste Signaling
    Sweet Taste Signaling0.72
    4Peptide ligand-binding receptors
    GPCR ligand binding0.71
    5Carbohydrate digestion and absorption
    Carbohydrate digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TAS1R2
        Sweet Taste Signaling

    1 Reactome Pathway for TAS1R2
        Class C/3 (Metabotropic glutamate/pheromone receptors)


    2 Kegg Pathways  (Kegg details for TAS1R2):
        Taste transduction
    Carbohydrate digestion and absorption


    TAS1R2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAS1R2
    Interactions:

        Search GeneGlobe Interaction Network for TAS1R2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TAS1R2 (Q8TE233 ENSP000003645204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAS1R3Q7RTX03, ENSP000003444114I2D: score=1 STRING: ENSP00000344411
    GNASENSP000003601414STRING: ENSP00000360141
    GNAT3ENSP000003813394STRING: ENSP00000381339
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001582detection of chemical stimulus involved in sensory perception of sweet taste IDA16720576
    GO:0007186G-protein coupled receptor signaling pathway IC16720576
    GO:0032467positive regulation of cytokinesis IMP--
    GO:0050916sensory perception of sweet taste IDA11917125

    TAS1R2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAS1R2 (TS1R2)

    1 HMDB Compound for TAS1R2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AspartameAspartylphenylalanine methyl ester (see all 12)22839-47-0--

    1 DrugBank Compound for TAS1R2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aspartame1-Methyl N-L-alpha-aspartyl-L-phenylalanate (see all 17)22839-47-0targetagonist15353592 17139284 17016423 17168764



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAS1R2 gene: 
    NM_152232.2  

    Unigene Cluster for TAS1R2:

    Taste receptor, type 1, member 2
    Hs.553548
    Unigene Representative Sequence: NM_152232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375371(uc001bba.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat TAS1R2

    2 AceView cDNA sequences:

    NM_152232 BK000151 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAS1R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGGACT
    TAS1R2 Expression
    About this image

    TAS1R2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAS1R2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553548
        Custom PCR Arrays for TAS1R2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAS1R2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tas1r21 , 5 taste receptor, type 1, member 21, 5 77.63(n)1
    69.85(a)1
      4 (70.82 cM)5
    837701  NM_031873.11  NP_114079.11 
     1396535385 
    lizard
    (Anolis carolinensis)
    Reptilia TAS1R26
    taste receptor, type 1, member 2
    47(a)
    1 ↔ 1
    AAWZ02036459(14990-22806)
    zebrafish
    (Danio rerio)
    Actinopterygii tas1r2.16
    tas1r2.26
    taste receptor, type 1, member 2, tandem duplicate...
    taste receptor, type 1, member 2, tandem duplicate...
    33(a)
    33(a)
    1 ↔ many
    1 ↔ many
    8(48741456-48751614) ENSDARG00000053135
    8(48813560-48823160) ENSDARG00000059397


    ENSEMBL Gene Tree for TAS1R2 (if available)
    TreeFam Gene Tree for TAS1R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAS1R2 gene
    GRM72  GRM42  GRM82  TAS1R32  GRM22  GRM32  TAS1R12  GRM62  
    GRM52  GRM12  GPRC6A2  
    4 SIMAP similar genes for TAS1R2 using alignment to 1 protein entry:     TS1R2_HUMAN:
    TAS1R1    GPRC6A    TAS1R3    CASR

    TAS1R2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAS1R2 (see all 706)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011970241,2
    Cuntested119181066(+) GGAGGC/TGATCC 2 T A mis10--------
    rs1926288581,2
    --19165605(+) AGCTCA/TCATGC 1 -- ds50010--------
    rs1144087311,2
    F--19165615(+) CTGAAC/AGGCAG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs49205541,2
    C,F,A,H--19165630(+) CACCCG/ACCTAC 1 -- ds50017Minor allele frequency- A:0.41NA WA CSA EA 370
    rs1430967041,2
    C--19165661(+) GAACAA/GCCCAC 1 -- ds50010--------
    rs1851387601,2
    --19165664(+) CAGCCC/TACCCA 1 -- ds50010--------
    rs1996106021,2
    C--19165896(+) AGACA-/CCCAAC 1 -- ds50010--------
    rs1477618991,2
    C--19166047(+) CGCCTC/TCCAAC 1 -- ds50010--------
    rs1411479361,2
    C--19166078(+) CCAGAC/TGCCAC 1 -- ds50010--------
    rs2007776951,2
    --19166084(+) GCCACC/TGGATG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TAS1R2 (19166093 - 19186176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TAS1R2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870906CNV Gain21882294

    Human Gene Mutation Database (HGMD): TAS1R2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAS1R2
    DNA2.0 Custom Variant and Variant Library Synthesis for TAS1R2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606226    OMIM disorders: --

    5 diseases for TAS1R2:    
    About MalaCards
    bile duct carcinoma    dental caries    anorexia nervosa    parkinson's disease
    obesity

    1 disease from the University of Copenhagen DISEASES database for TAS1R2:
    Dental caries

    TAS1R2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAS1R2
    Human Genome Epidemiology (HuGE) Navigator: TAS1R2 (4 documents)

    Export disorders for TAS1R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAS1R2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with TAS1R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. (PubMed id 20070850)1, 4 Edwards T.L....Martin E.R. (Ann. Hum. Genet. 2010)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Taste genes associated with dental caries. (PubMed id 20858777)1, 4 Wendell S....Marazita M.L. (J. Dent. Res. 2010)
    4. Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. (PubMed id 20943793)1, 4 Eny K.M....El-Sohemy A. (Am. J. Clin. Nutr. 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Human receptors for sweet and umami taste. (PubMed id 11917125)1, 2 Li X.... Adler E. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. (PubMed id 20302879)1, 9 Assadi-Porter F.M....Max M. (J. Mol. Biol. 2010)
    8. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    9. Temperature-dependent conformational change affecting Tyr11 and sweetness loops of brazzein. (PubMed id 23349025)1 Cornilescu C.C....Assadi-Porter F.M. (Proteins 2013)
    10. Association of GLUT2 and TAS1R2 genotypes with risk for dental caries. (PubMed id 23257979)1 Kulkarni G.V....El-Sohemy A. (Caries Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80834 HGNC: 14905 AceView: TAS1R2 Ensembl:ENSG00000179002 euGenes: HUgn80834
    ECgene: TAS1R2 Kegg: 80834 H-InvDB: TAS1R2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAS1R2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/055

    (Patent information from GeneIP,
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    Patent Information for TAS1R2 gene:
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