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Aliases for TAS1R2 Gene

Aliases for TAS1R2 Gene

  • Taste Receptor, Type 1, Member 2 2 3
  • G Protein-Coupled Receptor 71 2 3
  • G-Protein Coupled Receptor 71 3 4
  • Sweet Taste Receptor T1R2 3 4
  • GPR71 3 4
  • T1R2 3 4
  • TR2 3 4

External Ids for TAS1R2 Gene

Previous HGNC Symbols for TAS1R2 Gene

  • GPR71

Previous GeneCards Identifiers for TAS1R2 Gene

  • GC00U990928
  • GC01M018208
  • GC01M018599
  • GC01M018911
  • GC01M019038
  • GC01M019166
  • GC01M017412

Summaries for TAS1R2 Gene

GeneCards Summary for TAS1R2 Gene

TAS1R2 (Taste Receptor, Type 1, Member 2) is a Protein Coding gene. Diseases associated with TAS1R2 include dental caries. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for TAS1R2 Gene

  • Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

Gene Wiki entry for TAS1R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R2 Gene

Genomics for TAS1R2 Gene

Regulatory Elements for TAS1R2 Gene

Genomic Location for TAS1R2 Gene

Chromosome:
1
Start:
18,839,599 bp from pter
End:
18,859,682 bp from pter
Size:
20,084 bases
Orientation:
Minus strand

Genomic View for TAS1R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R2 Gene

Proteins for TAS1R2 Gene

  • Protein details for TAS1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE23-TS1R2_HUMAN
    Recommended name:
    Taste receptor type 1 member 2
    Protein Accession:
    Q8TE23
    Secondary Accessions:
    • Q5TZ19

    Protein attributes for TAS1R2 Gene

    Size:
    839 amino acids
    Molecular mass:
    95183 Da
    Quaternary structure:
    • Forms heterodimers with TAS1R3

neXtProt entry for TAS1R2 Gene

Proteomics data for TAS1R2 Gene at MOPED

Post-translational modifications for TAS1R2 Gene

  • Glycosylation at Asn 84, Asn 248, Asn 292, Asn 312, Asn 368, Asn 428, Asn 487, and Asn 527
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS1R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAS1R2 Gene

Domains & Families for TAS1R2 Gene

Gene Families for TAS1R2 Gene

Suggested Antigen Peptide Sequences for TAS1R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE23

UniProtKB/Swiss-Prot:

TS1R2_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R2: view

Function for TAS1R2 Gene

Molecular function for TAS1R2 Gene

UniProtKB/Swiss-Prot Function:
Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

Gene Ontology (GO) - Molecular Function for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding --
GO:0008527 contributes_to taste receptor activity IDA 16720576
GO:0033041 contributes_to sweet taste receptor activity IDA 16720576
GO:0046982 protein heterodimerization activity NAS 11917125
genes like me logo Genes that share ontologies with TAS1R2: view
genes like me logo Genes that share phenotypes with TAS1R2: view

Animal Models for TAS1R2 Gene

MGI Knock Outs for TAS1R2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS1R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TAS1R2 Gene

Localization for TAS1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS1R2 Gene COMPARTMENTS Subcellular localization image for TAS1R2 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 11917125
GO:0043235 receptor complex IDA 23382219
GO:1903767 sweet taste receptor complex IDA 16720576
genes like me logo Genes that share ontologies with TAS1R2: view

Pathways & Interactions for TAS1R2 Gene

genes like me logo Genes that share pathways with TAS1R2: view

Pathways by source for TAS1R2 Gene

Gene Ontology (GO) - Biological Process for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste IDA 16720576
GO:0007186 G-protein coupled receptor signaling pathway IC 16720576
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050916 sensory perception of sweet taste IDA 11917125
genes like me logo Genes that share ontologies with TAS1R2: view

No data available for SIGNOR curated interactions for TAS1R2 Gene

Drugs & Compounds for TAS1R2 Gene

(1) Drugs for TAS1R2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspartame Approved Nutra Target, agonist 0
genes like me logo Genes that share compounds with TAS1R2: view

Transcripts for TAS1R2 Gene

mRNA/cDNA for TAS1R2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS1R2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R2 Gene

No ASD Table

Relevant External Links for TAS1R2 Gene

GeneLoc Exon Structure for
TAS1R2
ECgene alternative splicing isoforms for
TAS1R2

Expression for TAS1R2 Gene

mRNA expression in normal human tissues for TAS1R2 Gene

SOURCE GeneReport for Unigene cluster for TAS1R2 Gene Hs.553548

genes like me logo Genes that share expression patterns with TAS1R2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TAS1R2 Gene

Orthologs for TAS1R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAS1R2 35
  • 82.4 (n)
  • 75.36 (a)
TAS1R2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS1R2 35
  • 83.21 (n)
  • 76.44 (a)
mouse
(Mus musculus)
Mammalia Tas1r2 35
  • 77.63 (n)
  • 69.85 (a)
Tas1r2 16
Tas1r2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100615078 35
  • 96.86 (n)
  • 95.95 (a)
TAS1R2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas1r2 35
  • 78.4 (n)
  • 71.24 (a)
oppossum
(Monodelphis domestica)
Mammalia TAS1R2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS1R2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAS1R2 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r2.1 36
  • 33 (a)
OneToMany
tas1r2.2 36
  • 33 (a)
OneToMany
Species with no ortholog for TAS1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R2 Gene

ENSEMBL:
Gene Tree for TAS1R2 (if available)
TreeFam:
Gene Tree for TAS1R2 (if available)

Paralogs for TAS1R2 Gene

Paralogs for TAS1R2 Gene

(4) SIMAP similar genes for TAS1R2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAS1R2: view

Variants for TAS1R2 Gene

Sequence variations from dbSNP and Humsavar for TAS1R2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs72950006 -- 18,852,624(+) CTCTA(A/G)ACAAA intron-variant
rs115643549 -- 18,844,307(+) TGGAA(G/T)GAGCA intron-variant
rs115672344 -- 18,840,172(+) CGCAC(A/G)GCGAT reference, synonymous-codon
rs115811652 -- 18,859,788(+) GAGCA(A/G)GTGGA upstream-variant-2KB
rs115820797 -- 18,841,860(+) GGAGG(A/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAS1R2 Gene

Variant ID Type Subtype PubMed ID
nsv870906 CNV Gain 21882294

Variation tolerance for TAS1R2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS1R2 Gene

HapMap Linkage Disequilibrium report
TAS1R2
Human Gene Mutation Database (HGMD)
TAS1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R2 Gene

Disorders for TAS1R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAS1R2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries pit and fissure
- elite association

Relevant External Links for TAS1R2

Genetic Association Database (GAD)
TAS1R2
Human Genome Epidemiology (HuGE) Navigator
TAS1R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS1R2
genes like me logo Genes that share disorders with TAS1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS1R2 Gene

Publications for TAS1R2 Gene

  1. Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. (PMID: 20302879) Assadi-Porter F.M. … Max M. (J. Mol. Biol. 2010) 23 67
  2. Involvement of the calcium-sensing receptor in human taste perception. (PMID: 19892707) Ohsu T. … Eto Y. (J. Biol. Chem. 2010) 23 67
  3. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. (PMID: 19559618) Fushan A.A. … Drayna D. (Curr. Biol. 2009) 23 67
  4. Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1. (PMID: 17389641) Gupta P. … Wei L.N. (Nucleic Acids Res. 2007) 23 67
  5. CCAAT/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1. (PMID: 17928076) Toyono T. … Toyoshima K. (Biochim. Biophys. Acta 2007) 23 67

Products for TAS1R2 Gene

Sources for TAS1R2 Gene

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