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Aliases for TAS1R1 Gene

Aliases for TAS1R1 Gene

  • Taste Receptor, Type 1, Member 1 2 3
  • T1R1 3 4 6
  • G Protein-Coupled Receptor 70 2 3
  • G-Protein Coupled Receptor 70 3 4
  • GPR70 3 4
  • TR1 3 4
  • Seven Transmembrane Helix Receptor 3
  • Taste Receptor Type 1 Member 1 3
  • GM148 3

External Ids for TAS1R1 Gene

Previous Symbols for TAS1R1 Gene

  • GPR70

Summaries for TAS1R1 Gene

Entrez Gene Summary for TAS1R1 Gene

  • The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for TAS1R1 Gene

TAS1R1 (Taste Receptor, Type 1, Member 1) is a Protein Coding gene. Diseases associated with TAS1R1 include bile duct carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and taste receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for TAS1R1 Gene

  • Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Wiki entry for TAS1R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R1 Gene

Genomics for TAS1R1 Gene

Genomic Location for TAS1R1 Gene

Start:
6,555,181 bp from pter
End:
6,579,757 bp from pter
Size:
24,577 bases
Orientation:
Plus strand

Genomic View for TAS1R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R1 Gene

Regulatory Elements for TAS1R1 Gene

Proteins for TAS1R1 Gene

  • Protein details for TAS1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX1-TS1R1_HUMAN
    Recommended name:
    Taste receptor type 1 member 1
    Protein Accession:
    Q7RTX1
    Secondary Accessions:
    • B2RMX0
    • Q5SY22
    • Q5SY24
    • Q8NGZ7
    • Q8TDJ7
    • Q8TDJ8
    • Q8TDJ9
    • Q8TDK0

    Protein attributes for TAS1R1 Gene

    Size:
    841 amino acids
    Molecular mass:
    93074 Da
    Quaternary structure:
    • Forms heterodimers with TAS1R3
    SequenceCaution:
    • Sequence=AAL91359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL91360.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL91361.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TAS1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAS1R1 Gene

Proteomics data for TAS1R1 Gene at MOPED

Post-translational modifications for TAS1R1 Gene

  • Glycosylation at Asn87, Asn88, Asn95, Asn291, Asn479, and Asn529

Other Protein References for TAS1R1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS1R1 Gene

Domains for TAS1R1 Gene

Gene Families for TAS1R1 Gene

HGNC:
  • TAS1R :Taste receptors / Type 1
  • TASNR :GPCR / Unclassified : Taste receptors
IUPHAR :

UniProtKB/Swiss-Prot:

TS1R1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.:
    • Q7RTX1
genes like me logo Genes that share domains with TAS1R1: view

Function for TAS1R1 Gene

Molecular function for TAS1R1 Gene

UniProtKB/Swiss-Prot Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Ontology (GO) - Molecular Function for TAS1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity IDA 11917125
GO:0046982 protein heterodimerization activity NAS 11917125
genes like me logo Genes that share ontologies with TAS1R1: view
genes like me logo Genes that share phenotypes with TAS1R1: view

Animal Models for TAS1R1 Gene

MGI Knock Outs for TAS1R1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TAS1R1 Gene

Localization for TAS1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS1R1 Gene COMPARTMENTS Subcellular localization image for TAS1R1 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TAS1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 11917125
genes like me logo Genes that share ontologies with TAS1R1: view

Pathways for TAS1R1 Gene

genes like me logo Genes that share pathways with TAS1R1: view

Pathways by source for TAS1R1 Gene

Gene Ontology (GO) - Biological Process for TAS1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050912 detection of chemical stimulus involved in sensory perception of taste IEA --
GO:0050917 sensory perception of umami taste IDA 11917125
genes like me logo Genes that share ontologies with TAS1R1: view

Compounds for TAS1R1 Gene

(1) Novoseek inferred chemical compound relationships for TAS1R1 Gene

Compound -log(P) Hits PubMed IDs
glutamate 38.8 4
genes like me logo Genes that share compounds with TAS1R1: view

Transcripts for TAS1R1 Gene

mRNA/cDNA for TAS1R1 Gene

Unigene Clusters for TAS1R1 Gene

Taste receptor, type 1, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: - -
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TAS1R1 Gene

GeneLoc Exon Structure for
TAS1R1
ECgene alternative splicing isoforms for
TAS1R1

Expression for TAS1R1 Gene

mRNA expression in normal human tissues for TAS1R1 Gene

mRNA differential expression in normal tissues according to GTEx for TAS1R1 Gene

This gene is overexpressed in Testis (18.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAS1R1 Gene

SOURCE GeneReport for Unigene cluster for TAS1R1 Gene Hs.124574

genes like me logo Genes that share expressions with TAS1R1: view

Orthologs for TAS1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS1R1 36
  • 99.17 (n)
  • 98.69 (a)
TAS1R1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS1R1 36
  • 81.33 (n)
  • 75.86 (a)
TAS1R1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAS1R1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas1r1 36
  • 79.62 (n)
  • 73.98 (a)
Tas1r1 16
Tas1r1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAS1R1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS1R1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas1r1 36
  • 79.13 (n)
  • 74.17 (a)
chicken
(Gallus gallus)
Aves TAS1R1 36
  • 59.03 (n)
  • 48.23 (a)
TAS1R1 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAS1R1 37
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r1 36
  • 51.72 (n)
  • 41.4 (a)
tas1r1 37
  • 39 (a)
OneToOne
Species with no ortholog for TAS1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R1 Gene

ENSEMBL:
Gene Tree for TAS1R1 (if available)
TreeFam:
Gene Tree for TAS1R1 (if available)

Paralogs for TAS1R1 Gene

Paralogs for TAS1R1 Gene

Selected SIMAP similar genes for TAS1R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAS1R1: view

Variants for TAS1R1 Gene

Sequence variations from dbSNP and Humsavar for TAS1R1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2004236 -- 6,573,458(+) tctca(G/T)aaaga intron-variant
rs3062936 -- 6,572,285(-) GTCTC(-/AA)AAAAA intron-variant
rs3861755 -- 6,562,115(-) gcact(C/T)ccatt intron-variant
rs3908553 -- 6,561,861(-) CCCCA(C/T)GGCCT intron-variant
rs3986417 -- 6,561,951(-) ccttc(A/G)cagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAS1R1 Gene

Variant ID Type Subtype PubMed ID
nsv7880 CNV Gain+Loss 18304495
nsv831536 CNV Loss 17160897
nsv831647 CNV Loss 17160897
esv1249079 CNV Insertion 17803354
esv259781 OTHER Complex 20981092
dgv129n71 CNV Loss 21882294

Relevant External Links for TAS1R1 Gene

HapMap Linkage Disequilibrium report
TAS1R1
Human Gene Mutation Database (HGMD)
TAS1R1

Disorders for TAS1R1 Gene

(1) MalaCards Diseases for TAS1R1 Gene

Search for TAS1R1 Gene in MalaCards »

Relevant External Links for TAS1R1

Genetic Association Database (GAD)
TAS1R1
Human Genome Epidemiology (HuGE) Navigator
TAS1R1
genes like me logo Genes that share disorders with TAS1R1: view

No data available for UniProtKB/Swiss-Prot for TAS1R1 Gene

Publications for TAS1R1 Gene

  1. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. (PMID: 19587085) Chen Q.Y. … Breslin P.A. (Am. J. Clin. Nutr. 2009) 3 23 49
  2. Variation in umami perception and in candidate genes for the umami receptor in mice and humans. (PMID: 19625681) Shigemura N. … Ninomiya Y. (Am. J. Clin. Nutr. 2009) 3 23
  3. Genetic and molecular basis of individual differences in human umami taste perception. (PMID: 19696921) Shigemura N. … Ninomiya Y. (PLoS ONE 2009) 3 23
  4. Human receptors for sweet and umami taste. (PMID: 11917125) Li X. … Adler E. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TAS1R1 Gene

Sources for TAS1R1 Gene

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