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Aliases for TAS1R1 Gene

Aliases for TAS1R1 Gene

  • Taste 1 Receptor Member 1 2 3 5
  • Taste Receptor, Type 1, Member 1 2 3
  • G Protein-Coupled Receptor 70 2 3
  • G-Protein Coupled Receptor 70 3 4
  • GPR70 3 4
  • T1R1 3 4
  • TR1 3 4
  • Seven Transmembrane Helix Receptor 3
  • GM148 3

External Ids for TAS1R1 Gene

Previous HGNC Symbols for TAS1R1 Gene

  • GPR70

Previous GeneCards Identifiers for TAS1R1 Gene

  • GC01P006207
  • GC01P006439
  • GC01P006325
  • GC01P006326
  • GC01P006550
  • GC01P006615
  • GC01P005763

Summaries for TAS1R1 Gene

Entrez Gene Summary for TAS1R1 Gene

  • The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for TAS1R1 Gene

TAS1R1 (Taste 1 Receptor Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for TAS1R1 Gene

  • Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Wiki entry for TAS1R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R1 Gene

Genomics for TAS1R1 Gene

Regulatory Elements for TAS1R1 Gene

Promoters for TAS1R1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAS1R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS1R1 Gene

Chromosome:
1
Start:
6,555,181 bp from pter
End:
6,579,757 bp from pter
Size:
24,577 bases
Orientation:
Plus strand

Genomic View for TAS1R1 Gene

Genes around TAS1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R1 Gene

Proteins for TAS1R1 Gene

  • Protein details for TAS1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX1-TS1R1_HUMAN
    Recommended name:
    Taste receptor type 1 member 1
    Protein Accession:
    Q7RTX1
    Secondary Accessions:
    • B2RMX0
    • Q5SY22
    • Q5SY24
    • Q8NGZ7
    • Q8TDJ7
    • Q8TDJ8
    • Q8TDJ9
    • Q8TDK0

    Protein attributes for TAS1R1 Gene

    Size:
    841 amino acids
    Molecular mass:
    93074 Da
    Quaternary structure:
    • Forms heterodimers with TAS1R3.
    SequenceCaution:
    • Sequence=AAL91359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL91360.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL91361.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TAS1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAS1R1 Gene

Proteomics data for TAS1R1 Gene at MOPED

Post-translational modifications for TAS1R1 Gene

  • Glycosylation at Asn 87, Asn 88, Asn 95, Asn 291, Asn 479, and Asn 529
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS1R1 Gene

No data available for DME Specific Peptides for TAS1R1 Gene

Domains & Families for TAS1R1 Gene

Gene Families for TAS1R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTX1

UniProtKB/Swiss-Prot:

TS1R1_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R1: view

Function for TAS1R1 Gene

Molecular function for TAS1R1 Gene

UniProtKB/Swiss-Prot Function:
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
genes like me logo Genes that share phenotypes with TAS1R1: view

Animal Models for TAS1R1 Gene

MGI Knock Outs for TAS1R1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TAS1R1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAS1R1 Gene

Localization for TAS1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS1R1 Gene COMPARTMENTS Subcellular localization image for TAS1R1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TAS1R1 Gene

Pathways & Interactions for TAS1R1 Gene

genes like me logo Genes that share pathways with TAS1R1: view

Pathways by source for TAS1R1 Gene

Gene Ontology (GO) - Biological Process for TAS1R1 Gene

None

No data available for SIGNOR curated interactions for TAS1R1 Gene

Drugs & Compounds for TAS1R1 Gene

(1) Additional Compounds for TAS1R1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAS1R1: view

Transcripts for TAS1R1 Gene

Unigene Clusters for TAS1R1 Gene

Taste receptor, type 1, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: - -
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TAS1R1 Gene

GeneLoc Exon Structure for
TAS1R1
ECgene alternative splicing isoforms for
TAS1R1

Expression for TAS1R1 Gene

mRNA expression in normal human tissues for TAS1R1 Gene

mRNA differential expression in normal tissues according to GTEx for TAS1R1 Gene

This gene is overexpressed in Testis (x18.4).

Protein differential expression in normal tissues from HIPED for TAS1R1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS1R1 Gene



SOURCE GeneReport for Unigene cluster for TAS1R1 Gene Hs.124574

genes like me logo Genes that share expression patterns with TAS1R1: view

Protein tissue co-expression partners for TAS1R1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TAS1R1 Gene

Orthologs for TAS1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS1R1 35
  • 99.17 (n)
  • 98.69 (a)
TAS1R1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS1R1 36
  • 76 (a)
OneToOne
TAS1R1 35
  • 81.33 (n)
  • 75.86 (a)
dog
(Canis familiaris)
Mammalia TAS1R1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas1r1 16
Tas1r1 36
  • 74 (a)
OneToOne
Tas1r1 35
  • 79.62 (n)
  • 73.98 (a)
oppossum
(Monodelphis domestica)
Mammalia TAS1R1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS1R1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tas1r1 35
  • 79.13 (n)
  • 74.17 (a)
chicken
(Gallus gallus)
Aves TAS1R1 35
  • 59.03 (n)
  • 48.23 (a)
TAS1R1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAS1R1 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r1 36
  • 39 (a)
OneToOne
tas1r1 35
  • 51.72 (n)
  • 41.4 (a)
Species with no ortholog for TAS1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R1 Gene

ENSEMBL:
Gene Tree for TAS1R1 (if available)
TreeFam:
Gene Tree for TAS1R1 (if available)

Paralogs for TAS1R1 Gene

Paralogs for TAS1R1 Gene

(6) SIMAP similar genes for TAS1R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAS1R1: view

Variants for TAS1R1 Gene

Sequence variations from dbSNP and Humsavar for TAS1R1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10864628 - 6,575,171(+) ACAAG(A/G)AGGCC intron-variant, reference, missense
rs34160967 - 6,575,246(+) TCATG(A/C/G)CACAC intron-variant, reference, missense
rs35118458 - 6,576,996(+) CCAGC(A/G)AGTGG reference, missense
rs2004236 -- 6,573,458(+) tctca(G/T)aaaga intron-variant
rs3062936 -- 6,572,285(-) GTCTC(-/AA)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAS1R1 Gene

Variant ID Type Subtype PubMed ID
nsv7880 CNV Gain+Loss 18304495
nsv831536 CNV Loss 17160897
nsv831647 CNV Loss 17160897
esv1249079 CNV Insertion 17803354
esv259781 OTHER Complex 20981092
dgv129n71 CNV Loss 21882294

Variation tolerance for TAS1R1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS1R1 Gene

HapMap Linkage Disequilibrium report
TAS1R1
Human Gene Mutation Database (HGMD)
TAS1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R1 Gene

Disorders for TAS1R1 Gene

Relevant External Links for TAS1R1

Genetic Association Database (GAD)
TAS1R1
Human Genome Epidemiology (HuGE) Navigator
TAS1R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS1R1

No disorders were found for TAS1R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS1R1 Gene

Publications for TAS1R1 Gene

  1. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. (PMID: 19587085) Chen Q.Y. … Breslin P.A. (Am. J. Clin. Nutr. 2009) 3 23 48 67
  2. Variation in umami perception and in candidate genes for the umami receptor in mice and humans. (PMID: 19625681) Shigemura N. … Ninomiya Y. (Am. J. Clin. Nutr. 2009) 3 23
  3. Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate. (PMID: 19571223) Raliou M. … Faurion A. (Am. J. Clin. Nutr. 2009) 3 23
  4. Genetic and molecular basis of individual differences in human umami taste perception. (PMID: 19696921) Shigemura N. … Ninomiya Y. (PLoS ONE 2009) 3 23
  5. Three sweet receptor genes are clustered in human chromosome 1. (PMID: 12856281) Liao J. … Schultz P.G. (Mamm. Genome 2003) 2 3

Products for TAS1R1 Gene

Sources for TAS1R1 Gene

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