Aliases for TAS1R1 Gene
External Ids for TAS1R1 Gene
Previous HGNC Symbols for TAS1R1 Gene
Previous GeneCards Identifiers for TAS1R1 Gene
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for TAS1R1 Gene
TAS1R1 (Taste Receptor, Type 1, Member 1) is a Protein Coding gene. Diseases associated with TAS1R1 include bile duct carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and taste receptor activity. An important paralog of this gene is GRM1.
UniProtKB/Swiss-Prot for TAS1R1 Gene
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.