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Aliases for TARSL2 Gene

Aliases for TARSL2 Gene

  • Threonyl-TRNA Synthetase-Like 2 2 3 5
  • Threonyl-TRNA Synthetase-Like Protein 2 3 4
  • Threonyl-TRNA Synthetase 3 4
  • EC 6.1.1.3 4 63
  • ThrRS 3 4
  • Probable Threonyl-TRNA Synthetase 2, Cytoplasmic 3
  • Threonine--TRNA Ligase 3

External Ids for TARSL2 Gene

Previous GeneCards Identifiers for TARSL2 Gene

  • GC15M100013
  • GC15M102193
  • GC15M078317

Summaries for TARSL2 Gene

GeneCards Summary for TARSL2 Gene

TARSL2 (Threonyl-TRNA Synthetase-Like 2) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and ligase activity, forming aminoacyl-tRNA and related compounds. An important paralog of this gene is TARS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARSL2 Gene

Genomics for TARSL2 Gene

Regulatory Elements for TARSL2 Gene

Enhancers for TARSL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TARSL2 on UCSC Golden Path with GeneCards custom track

Promoters for TARSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TARSL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TARSL2 Gene

Chromosome:
15
Start:
101,653,598 bp from pter
End:
101,724,604 bp from pter
Size:
71,007 bases
Orientation:
Minus strand

Genomic View for TARSL2 Gene

Genes around TARSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARSL2 Gene

Proteins for TARSL2 Gene

  • Protein details for TARSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RTX5-SYTC2_HUMAN
    Recommended name:
    Probable threonine--tRNA ligase 2, cytoplasmic
    Protein Accession:
    A2RTX5
    Secondary Accessions:
    • B2RMP7
    • Q6B0A1
    • Q6IS76
    • Q96LW3
    • Q96MP4

    Protein attributes for TARSL2 Gene

    Size:
    802 amino acids
    Molecular mass:
    92646 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71554.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TARSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARSL2 Gene

Proteomics data for TARSL2 Gene at MOPED

Post-translational modifications for TARSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TARSL2 Gene

Domains & Families for TARSL2 Gene

Suggested Antigen Peptide Sequences for TARSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2RTX5

UniProtKB/Swiss-Prot:

SYTC2_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARSL2: view

No data available for Gene Families for TARSL2 Gene

Function for TARSL2 Gene

Molecular function for TARSL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Enzyme Numbers (IUBMB) for TARSL2 Gene

Gene Ontology (GO) - Molecular Function for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds IEA --
genes like me logo Genes that share ontologies with TARSL2: view

Animal Model Products

miRNA for TARSL2 Gene

miRTarBase miRNAs that target TARSL2

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TARSL2 Gene

Localization for TARSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARSL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARSL2 Gene COMPARTMENTS Subcellular localization image for TARSL2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TARSL2 Gene

Pathways & Interactions for TARSL2 Gene

SuperPathways for TARSL2 Gene

Superpath Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with TARSL2: view

Pathways by source for TARSL2 Gene

1 KEGG pathway for TARSL2 Gene

Gene Ontology (GO) - Biological Process for TARSL2 Gene

None

No data available for SIGNOR curated interactions for TARSL2 Gene

Drugs & Compounds for TARSL2 Gene

(4) Drugs for TARSL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
L-Threonine Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for TARSL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TARSL2: view

Transcripts for TARSL2 Gene

Unigene Clusters for TARSL2 Gene

Threonyl-tRNA synthetase-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TARSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - - -
SP2: - - - - - - -
SP3: - - -
SP4:

Relevant External Links for TARSL2 Gene

GeneLoc Exon Structure for
TARSL2
ECgene alternative splicing isoforms for
TARSL2

Expression for TARSL2 Gene

mRNA expression in normal human tissues for TARSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TARSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Rectum (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARSL2 Gene



SOURCE GeneReport for Unigene cluster for TARSL2 Gene Hs.657163

genes like me logo Genes that share expression patterns with TARSL2: view

Protein tissue co-expression partners for TARSL2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TARSL2 Gene

Orthologs for TARSL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARSL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TARSL2 35
  • 83.17 (n)
  • 82.12 (a)
TARSL2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARSL2 35
  • 88.61 (n)
  • 88.19 (a)
TARSL2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tarsl2 35
  • 85.18 (n)
  • 86.89 (a)
Tarsl2 16
Tarsl2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TARSL2 35
  • 99.42 (n)
  • 99.25 (a)
TARSL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tarsl2 35
  • 82.81 (n)
  • 83.18 (a)
oppossum
(Monodelphis domestica)
Mammalia TARSL2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TARSL2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TARSL2 35
  • 75.83 (n)
  • 77.03 (a)
TARSL2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TARSL2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tarsl2 35
  • 71.61 (n)
  • 74.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18083 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01081822.1 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 36
  • 63 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tars-1 36
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 36
  • 53 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.2547 35
wheat
(Triticum aestivum)
Liliopsida Ta.3509 35
corn
(Zea mays)
Liliopsida Zm.6559 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
ManyToMany
Species with no ortholog for TARSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TARSL2 Gene

ENSEMBL:
Gene Tree for TARSL2 (if available)
TreeFam:
Gene Tree for TARSL2 (if available)

Paralogs for TARSL2 Gene

Paralogs for TARSL2 Gene

(3) SIMAP similar genes for TARSL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TARSL2: view

Variants for TARSL2 Gene

Sequence variations from dbSNP and Humsavar for TARSL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4965916 -- 101,692,536(+) GTTCT(A/G)GTATT intron-variant
rs4965917 -- 101,715,178(+) gtctc(A/G)ctctg intron-variant
rs4965918 -- 101,715,306(+) tacgc(C/G)cggct intron-variant
rs478338 -- 101,668,538(-) tcaca(C/T)ttagg intron-variant
rs481945 -- 101,668,175(-) ccaga(C/T)aggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TARSL2 Gene

Variant ID Type Subtype PubMed ID
nsv457293 CNV Gain 19166990
dgv113e55 CNV Gain 17911159
dgv2452n71 CNV Gain 21882294
dgv2453n71 CNV Gain 21882294
nsv528761 CNV Gain 19592680
dgv2454n71 CNV Gain 21882294
esv2667525 CNV Deletion 23128226
esv29627 CNV Loss 19812545
nsv904616 CNV Gain 21882294
nsv482948 CNV Complex 15286789
nsv523315 CNV Gain 19592680
nsv827470 CNV Gain 20364138
esv1005771 CNV Deletion 20482838
nsv1693 CNV Insertion 18451855
esv2660030 CNV Deletion 23128226
esv3057 CNV Deletion 18987735
esv1418059 CNV Deletion 17803354
nsv521896 CNV Gain 19592680
nsv904618 CNV Gain 21882294
nsv904619 CNV Gain 21882294

Variation tolerance for TARSL2 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TARSL2 Gene

Disorders for TARSL2 Gene

Relevant External Links for TARSL2

Genetic Association Database (GAD)
TARSL2
Human Genome Epidemiology (HuGE) Navigator
TARSL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TARSL2

No disorders were found for TARSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TARSL2 Gene

Publications for TARSL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TARSL2 Gene

Sources for TARSL2 Gene

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