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Aliases for TARSL2 Gene

Aliases for TARSL2 Gene

  • Threonyl-TRNA Synthetase-Like 2 2 3
  • Threonyl-TRNA Synthetase-Like Protein 2 3 4
  • Threonyl-TRNA Synthetase 3 4
  • EC 4 63
  • ThrRS 3 4
  • Probable Threonyl-TRNA Synthetase 2, Cytoplasmic 3
  • Probable Threonine--TRNA Ligase 2, Cytoplasmic 3
  • Threonine--TRNA Ligase 3

External Ids for TARSL2 Gene

Previous GeneCards Identifiers for TARSL2 Gene

  • GC15M100013
  • GC15M102193
  • GC15M078317

Summaries for TARSL2 Gene

GeneCards Summary for TARSL2 Gene

TARSL2 (Threonyl-TRNA Synthetase-Like 2) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation. GO annotations related to this gene include threonine-tRNA ligase activity. An important paralog of this gene is TARS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARSL2 Gene

Genomics for TARSL2 Gene

Regulatory Elements for TARSL2 Gene

Genomic Location for TARSL2 Gene

101,653,598 bp from pter
101,724,604 bp from pter
71,007 bases
Minus strand

Genomic View for TARSL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TARSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARSL2 Gene

Proteins for TARSL2 Gene

  • Protein details for TARSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable threonine--tRNA ligase 2, cytoplasmic
    Protein Accession:
    Secondary Accessions:
    • B2RMP7
    • Q6B0A1
    • Q6IS76
    • Q96LW3
    • Q96MP4

    Protein attributes for TARSL2 Gene

    802 amino acids
    Molecular mass:
    92646 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71554.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TARSL2 Gene


neXtProt entry for TARSL2 Gene

Proteomics data for TARSL2 Gene at MOPED

Post-translational modifications for TARSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TARSL2 Gene

Domains for TARSL2 Gene

Suggested Antigen Peptide Sequences for TARSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-II aminoacyl-tRNA synthetase family.
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARSL2: view

No data available for Gene Families for TARSL2 Gene

Function for TARSL2 Gene

Molecular function for TARSL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

Enzyme Numbers (IUBMB) for TARSL2 Gene

Gene Ontology (GO) - Molecular Function for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003674 molecular_function ND --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004829 threonine-tRNA ligase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TARSL2: view

Animal Model Products

miRNA for TARSL2 Gene

miRTarBase miRNAs that target TARSL2

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TARSL2 Gene

Localization for TARSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARSL2 Gene


Subcellular locations from

Jensen Localization Image for TARSL2 Gene COMPARTMENTS Subcellular localization image for TARSL2 gene
Compartment Confidence
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TARSL2: view

Pathways for TARSL2 Gene

SuperPathways for TARSL2 Gene

Superpath Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with TARSL2: view

Pathways by source for TARSL2 Gene

1 KEGG pathway for TARSL2 Gene

Gene Ontology (GO) - Biological Process for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation --
GO:0006435 threonyl-tRNA aminoacylation IEA --
GO:0008150 biological_process ND --
GO:0043039 tRNA aminoacylation --
genes like me logo Genes that share ontologies with TARSL2: view

Drugs for TARSL2 Gene

(5) HMDB Compounds for TARSL2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • (2S,3R)-(-)-Threonine
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with TARSL2: view

Transcripts for TARSL2 Gene

Unigene Clusters for TARSL2 Gene

Threonyl-tRNA synthetase-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TARSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - - -
SP2: - - - - - - -
SP3: - - -

Relevant External Links for TARSL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TARSL2 Gene

mRNA expression in normal human tissues for TARSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TARSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Rectum (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARSL2 Gene

SOURCE GeneReport for Unigene cluster for TARSL2 Gene Hs.657163

genes like me logo Genes that share expressions with TARSL2: view

Expression partners for TARSL2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TARSL2 Gene

Orthologs for TARSL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARSL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TARSL2 35
  • 83.17 (n)
  • 82.12 (a)
  • 82 (a)
(Canis familiaris)
Mammalia TARSL2 35
  • 88.61 (n)
  • 88.19 (a)
  • 89 (a)
(Mus musculus)
Mammalia Tarsl2 35
  • 85.18 (n)
  • 86.89 (a)
Tarsl2 16
Tarsl2 36
  • 87 (a)
(Pan troglodytes)
Mammalia TARSL2 35
  • 99.42 (n)
  • 99.25 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tarsl2 35
  • 82.81 (n)
  • 83.18 (a)
(Monodelphis domestica)
Mammalia TARSL2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TARSL2 36
  • 86 (a)
(Gallus gallus)
Aves TARSL2 35
  • 75.83 (n)
  • 77.03 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia TARSL2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tarsl2 35
  • 71.61 (n)
  • 74.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18083 35
(Danio rerio)
Actinopterygii CABZ01081822.1 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 36
  • 63 (a)
(Caenorhabditis elegans)
Secernentea tars-1 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 36
  • 53 (a)
(Glycine max)
eudicotyledons Gma.2547 35
(Triticum aestivum)
Liliopsida Ta.3509 35
(Zea mays)
Liliopsida Zm.6559 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
Species with no ortholog for TARSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TARSL2 Gene

Gene Tree for TARSL2 (if available)
Gene Tree for TARSL2 (if available)

Paralogs for TARSL2 Gene

Paralogs for TARSL2 Gene

(3) SIMAP similar genes for TARSL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TARSL2: view

Variants for TARSL2 Gene

Sequence variations from dbSNP and Humsavar for TARSL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs478338 -- 101,668,538(-) tcaca(C/T)ttagg intron-variant
rs481945 -- 101,668,175(-) ccaga(C/T)aggcc intron-variant
rs492538 -- 101,720,572(-) TATCA(A/G)AACAC intron-variant
rs516667 -- 101,663,828(-) GAAGA(C/T)GAATA intron-variant
rs517646 -- 101,657,369(-) ctgtc(A/G)gccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TARSL2 Gene

Variant ID Type Subtype PubMed ID
nsv457293 CNV Gain 19166990
dgv113e55 CNV Gain 17911159
dgv2452n71 CNV Gain 21882294
dgv2453n71 CNV Gain 21882294
nsv528761 CNV Gain 19592680
dgv2454n71 CNV Gain 21882294
esv2667525 CNV Deletion 23128226
esv29627 CNV Loss 19812545
nsv904616 CNV Gain 21882294
nsv482948 CNV Complex 15286789
nsv523315 CNV Gain 19592680
nsv827470 CNV Gain 20364138
esv1005771 CNV Deletion 20482838
nsv1693 CNV Insertion 18451855
esv2660030 CNV Deletion 23128226
esv3057 CNV Deletion 18987735
esv1418059 CNV Deletion 17803354
nsv521896 CNV Gain 19592680
nsv904618 CNV Gain 21882294
nsv904619 CNV Gain 21882294

Relevant External Links for TARSL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARSL2 Gene

Disorders for TARSL2 Gene

Relevant External Links for TARSL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TARSL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TARSL2 Gene

Publications for TARSL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PMID: 21987572) Lee K.A. … Doedens J.R. (J. Biol. Chem. 2011) 3
  5. Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. (PMID: 24312579) Kim K. … Lee C. (PLoS ONE 2013) 3

Products for TARSL2 Gene

Sources for TARSL2 Gene

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