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TARSL2 Gene

protein-coding   GIFtS: 52
GCID: GC15M102193

Threonyl-TRNA Synthetase-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Threonyl-TRNA Synthetase-Like 21 2     Probable Threonyl-TRNA Synthetase 2, Cytoplasmic2
Threonyl-TRNA Synthetase2 3     thrRS2
Threonyl-TRNA Synthetase-Like Protein 22 3     Threonine--TRNA Ligase2
EC 6.1.1.33 8     ThrRS3
Probable Threonine--TRNA Ligase 2, Cytoplasmic2     

External Ids:    HGNC: 247281   Entrez Gene: 1232832   Ensembl: ENSG000001854187   UniProtKB: A2RTX53   

Export aliases for TARSL2 gene to outside databases

Previous GC identifers: GC15M100013 GC15M078317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TARSL2 Gene:
TARSL2 (threonyl-tRNA synthetase-like 2) is a protein-coding gene. Diseases associated with TARSL2 include pneumonia, and tuberculosis. GO annotations related to this gene include threonine-tRNA ligase activity. An important paralog of this gene is TARS2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TARSL2 gene promoter:
         c-Fos   AP-1   ATF-2   NCX/Ncx   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   RORalpha2   Evi-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTARSL2 promoter sequence
   Search Chromatin IP Primers for TARSL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TARSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

TARSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARSL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M102193:  view genomic region     (about GC identifiers)

Start:
102,193,801 bp from pter      End:
102,264,807 bp from pter
Size:
71,007 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYTC2_HUMAN, A2RTX5 (See protein sequence)
Recommended Name: Probable threonine--tRNA ligase 2, cytoplasmic  
Size: 802 amino acids; 92646 Da
Sequence caution: Sequence=BAB71554.1; Type=Erroneous initiation;
Secondary accessions: B2RMP7 Q6B0A1 Q6IS76 Q96LW3 Q96MP4
Alternative splicing: 2 isoforms:  A2RTX5-1   A2RTX5-2   

Explore the universe of human proteins at neXtProt for TARSL2: NX_A2RTX5

Explore proteomics data for TARSL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TARSL2 (A2RTX5) (see all 33)
     WKTTPYQ  IKDAIGR  LCYGPPI  LKPMNCP 


    See TARSL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689547.2  
    ENSEMBL proteins: 
     ENSP00000338093   ENSP00000452740   ENSP00000439899  

    TARSL2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TARSL2

    TARSL2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TARSL2

    TARSL2 Assay Products:

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    Cloud-Clone Corp. ELISAs for TARSL2
    Cloud-Clone Corp. CLIAs for TARSL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR018163 Thr/Ala-tRNA-synth_IIc_edit
     IPR002314 aa-tRNA-synt_IIb_cons-dom
     IPR002320 Thr-tRNA-ligase_IIa
     IPR012675 Beta-grasp_dom
     IPR006195 aa-tRNA-synth_II

    Graphical View of Domain Structure for InterPro Entry A2RTX5

    ProtoNet protein and cluster: A2RTX5

    UniProtKB/Swiss-Prot: SYTC2_HUMAN, A2RTX5
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    TARSL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTC2_HUMAN, A2RTX5
    Catalytic activity: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

         Enzyme Number (IUBMB): EC 6.1.1.31 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003674molecular_function ND--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004829threonine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    TARSL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TARSL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TARSL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TARSL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TARSL2

    miRNA
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    miRTarBase miRNAs that target TARSL2:
    hsa-mir-186-5p (MIRT045233)

    Block miRNA regulation of human, mouse, rat TARSL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TARSL2 (see all 9):
    hsa-miR-4303 hsa-miR-577 hsa-miR-4324 hsa-miR-561 hsa-miR-513a-3p hsa-miR-4261 hsa-miR-3613-3p hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmidTARSL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TARSL2
    Predesigned siRNA for gene silencing in human, mouse, rat TARSL2

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for TARSL2 (see all 6)
    OriGene ORF clones in mouse, rat for TARSL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TARSL2 (NM_152334)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TARSL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARSL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TARSL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARSL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYTC2_HUMAN, A2RTX5: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    TARSL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TARSL2 About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    Aminoacyl-tRNA biosynthesis0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TARSL2):
        Aminoacyl-tRNA biosynthesis


    TARSL2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TARSL2
    Interactions:

        Search GeneGlobe Interaction Network for TARSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TARSL2 (A2RTX53 ENSP000003380934) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=1 STRING: ENSP00000229328
    ATG101Q9BSB43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation ----
    GO:0006435threonyl-tRNA aminoacylation IEA--
    GO:0008150biological_process ND--
    GO:0043039tRNA aminoacylation ----

    TARSL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TARSL2 (SYTC2)

    5 HMDB Compounds for TARSL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Threonine(2S,3R)-(-)-Threonine (see all 21)72-19-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TARSL2 gene: 
    NM_152334.2  

    Unigene Cluster for TARSL2:

    Threonyl-tRNA synthetase-like 2
    Hs.657163  [show with all ESTs]
    Unigene Representative Sequence: NM_152334
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335968(uc002bxl.3 uc002bxm.3 uc010usi.2) ENST00000558533
    ENST00000539112 ENST00000559492 ENST00000557811 ENST00000560150
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TARSL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TARSL2 (see all 9):
    hsa-miR-4303 hsa-miR-577 hsa-miR-4324 hsa-miR-561 hsa-miR-513a-3p hsa-miR-4261 hsa-miR-3613-3p hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmidTARSL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TARSL2
    Predesigned siRNA for gene silencing in human, mouse, rat TARSL2
    Clone
    Products:
         
    OriGene clones in human, mouse for TARSL2 (see all 6)
    OriGene ORF clones in mouse, rat for TARSL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TARSL2 (NM_152334)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TARSL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARSL2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TARSL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARSL2
      QuantiTect SYBR Green Assays in human, mouse, rat TARSL2
      QuantiFast Probe-based Assays in human, mouse, rat TARSL2

    Additional mRNA sequence: 

    AK056653.1 AK057734.1 AL833188.1 BC035827.1 BC069346.1 BC069811.1 BC074887.2 BC132671.1 
    BC136315.1 BC143943.1 

    6 DOTS entries:

    DT.100744610  DT.97789090  DT.112531  DT.91885764  DT.95329347  DT.97782147 

    Selected AceView cDNA sequences (see all 75):

    AI341514 AI865427 CF272335 CB127224 AW955745 BC074887 H79277 AI094304 
    BU736642 NM_152334 AI766284 CD106435 BX482664 AA437029 AW518683 BX500769 
    BM704475 BF172505 AK057734 AK056653 CA436963 BX494388 CD637731 BM672985 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TARSL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                                                                                        -     -     -                                 
    SP2:                          -     -     -     -                                                           -     -     -                                 
    SP3:                                                                                                              -     -           -                     
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for TARSL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TARSL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCAGCTG
    TARSL2 Expression
    About this image


    TARSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
    TARSL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TARSL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657163
        Custom PCR Arrays for TARSL2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TARSL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARSL2
    QuantiTect SYBR Green Assays in human, mouse, rat TARSL2
    QuantiFast Probe-based Assays in human, mouse, rat TARSL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TARSL2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tarsl21 , 5 threonyl-tRNA synthetase-like 21, 5 85.18(n)1
    86.89(a)1
      7 (35.23 cM)5
    2723961  NM_172310.21  NP_758514.21 
     656448985 
    chicken
    (Gallus gallus)
    Aves TARSL21 threonyl-tRNA synthetase-like 2 75.83(n)
    77.03(a)
      415389  XM_413774.4  XP_413774.3 
    lizard
    (Anolis carolinensis)
    Reptilia TARSL26
    threonyl-tRNA synthetase-like 2
    69(a)
    1 ↔ 1
    GL343644.1(17703-28093)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.180832 Xenopus laevis transcribed sequence with weak similarity more 78.81(n)    CF287106.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01081822.16
    Uncharacterized protein
    33(a)
    many ↔ many
    16(1211451-1215528) ENSDARG00000089680
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-thr6
    Threonyl-tRNA synthetase
    63(a)
    many ↔ many
    2L(12103734-12106894)
    worm
    (Caenorhabditis elegans)
    Secernentea tars-16
    Protein TARS-1, isoform b (tars-1) mRNA, complete ...
    57(a)
    1 → many
    II(11691326-11695657) WBGene00006617
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes THS16
    Threonyl-tRNA synthetase, essential cytoplasmic pr...
    53(a)
    1 → many
    IX(212499-214703) YIL078W
    soybean
    (Glycine max)
    eudicotyledons Gma.25472 Transcribed sequence with strong similarity to protein more 73.18(n)  
    corn
    (Zea mays)
    Liliopsida Zm.65592 Zea mays PCO073595 mRNA sequence 74.94(n)    AY103693.1 


    ENSEMBL Gene Tree for TARSL2 (if available)
    TreeFam Gene Tree for TARSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TARSL2 gene
    TARS22  MRPL392  TARS2  
    3 SIMAP similar genes for TARSL2 using alignment to 3 protein entries:     SYTC2_HUMAN (see all proteins):
    TARS    DKFZp667F1511    TARS2

    TARSL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TARSL2 (see all 1542)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413559231,2
    --102194602(+) TCCCCC/TGTGGA 1 -- ut310--------
    rs1870697651,2
    --102194648(+) CGTTCA/GTCGTC 1 -- ut310--------
    rs2010768921,2
    --102194772(+) AAATAC/TCAGGG 1 -- ut310--------
    rs1167901141,2
    C,F--102194803(+) TCAGCA/GTTGAG 2 N syn12Minor allele frequency- G:0.00WA NA 4666
    rs1929487391,2
    C--102194813(+) GTGTCC/TGTGTC 2 Q R mis10--------
    rs2005436281,2
    C--102194896(+) CGCACA/GTTTAC 2 N syn10--------
    rs1832893951,2
    C--102194962(+) ATGTAT/ATTTAA 1 -- int11Minor allele frequency- A:0.00EU 1173
    rs3695854901,2
    C--102194976(+) AGCAAC/TTTACC 1 -- int10--------
    rs6260731,2
    C,F,A,H--102195035(-) TAATAT/GTAGTG 1 -- int120Minor allele frequency- G:0.16EA NS NA CSA WA 3834
    rs1151989621,2
    C,F--102195177(+) GGGGGG/AAGCTC 1 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for TARSL2 (102193801 - 102264807 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TARSL2 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1418059CNV Deletion17803354
    esv1005771CNV Deletion20482838
    esv3057CNV Deletion18987735
    esv2660030CNV Deletion23128226
    esv2667525CNV Deletion23128226
    nsv1693CNV Insertion18451855
    esv29627CNV Loss19812545
    nsv523315CNV Gain19592680
    nsv528761CNV Gain19592680
    dgv2452n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    3 diseases for TARSL2:    
    About MalaCards
    pneumonia    tuberculosis    cerebritis


    TARSL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TARSL2
    Human Genome Epidemiology (HuGE) Navigator: TARSL2 (1 document)

    Export disorders for TARSL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TARSL2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TARSL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 123283 HGNC: 24728 AceView: FLJ25005 Ensembl:ENSG00000185418 euGenes: HUgn123283
    ECgene: TARSL2 Kegg: 123283 H-InvDB: TARSL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TARSL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TARSL2 gene:
    Search GeneIP for patents involving TARSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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