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Aliases for TARSL2 Gene

Aliases for TARSL2 Gene

  • Threonyl-TRNA Synthetase Like 2 2 3 5
  • Threonyl-TRNA Synthetase-Like Protein 2 3 4
  • EC 6.1.1.3 4 61
  • ThrRS 3 4
  • Probable Threonyl-TRNA Synthetase 2, Cytoplasmic 3
  • Probable Threonine--TRNA Ligase 2, Cytoplasmic 3
  • Threonyl-TRNA Synthetase 4
  • Threonine--TRNA Ligase 3

External Ids for TARSL2 Gene

Previous GeneCards Identifiers for TARSL2 Gene

  • GC15M100013
  • GC15M102193
  • GC15M078317

Summaries for TARSL2 Gene

GeneCards Summary for TARSL2 Gene

TARSL2 (Threonyl-TRNA Synthetase Like 2) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and ligase activity, forming aminoacyl-tRNA and related compounds. An important paralog of this gene is TARS.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARSL2 Gene

Genomics for TARSL2 Gene

Regulatory Elements for TARSL2 Gene

Enhancers for TARSL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G101640 1.4 Ensembl ENCODE dbSUPER 20.1 +82.6 82611 2.7 ELF3 PKNOX1 WRNIP1 ARID4B KLF17 ZNF2 RAD21 ZBTB40 RFX5 ZNF143 TM2D3 TARSL2 LOC100128108 SNRPA1 SELENOS RNU6-807P LINC02348
GH15G101650 1.4 ENCODE dbSUPER 10.7 +72.3 72337 2.8 PKNOX1 FOXA2 MLX ARNT CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 TM2D3 TARSL2 RNU6-807P
GH15G101683 0.7 ENCODE 9.8 +40.1 40128 1.2 STAT1 BHLHE40 DPF2 ATF2 FOSL1 CTBP1 JUND GATA3 STAT3 FOSL2 TM2D3 TARSL2
GH15G101293 1.4 FANTOM5 ENCODE 3.7 +429.3 429250 4.7 HNRNPUL1 PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 PRKXP1 RNU6-807P ENSG00000270127 SNRPA1 TARSL2 TM2D3 ENSG00000259172
GH15G101679 0.4 ENCODE 9.8 +44.7 44671 1.7 ZNF316 TM2D3 RNU6-807P TARSL2 LOC100128108
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TARSL2 on UCSC Golden Path with GeneCards custom track

Promoters for TARSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082078 504 1801 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for TARSL2 Gene

Chromosome:
15
Start:
101,653,598 bp from pter
End:
101,724,604 bp from pter
Size:
71,007 bases
Orientation:
Minus strand

Genomic View for TARSL2 Gene

Genes around TARSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARSL2 Gene

Proteins for TARSL2 Gene

  • Protein details for TARSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RTX5-SYTC2_HUMAN
    Recommended name:
    Probable threonine--tRNA ligase 2, cytoplasmic
    Protein Accession:
    A2RTX5
    Secondary Accessions:
    • B2RMP7
    • Q6B0A1
    • Q6IS76
    • Q96LW3
    • Q96MP4

    Protein attributes for TARSL2 Gene

    Size:
    802 amino acids
    Molecular mass:
    92646 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71554.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TARSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARSL2 Gene

Selected DME Specific Peptides for TARSL2 Gene

A2RTX5:
  • WKTTPYQ
  • IKDAIGR
  • LCYGPPI
  • LKPMNCP
  • QLDFQLP
  • YNSKLWE
  • WEKFQEEAK
  • TIQLDFQ
  • SPGSCFFLP
  • KPMNCPG
  • AFYGPKID
  • KNSSTYWEG
  • RFNLTYV
  • WHSSAHI
  • DGDDKKRPVI
  • HRPRSWRE
  • ENYGGKWP
  • RDHRKIG
  • IENGFYYD
  • GPHVRHTG
  • QDDAHIF
  • FKYNKFKCRIL
  • SGHWQHY
  • GDGAFYGPK
  • DDAHIFC
  • WPFWLSPR
  • RIYGISFP
  • DLCKGPH
  • LLEMFKYN
  • WLSPRQVMV
  • HRAILGS
  • TVYRCGPL
  • ADFGVLHR

Post-translational modifications for TARSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TARSL2 Gene

Domains & Families for TARSL2 Gene

Suggested Antigen Peptide Sequences for TARSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2RTX5

UniProtKB/Swiss-Prot:

SYTC2_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARSL2: view

No data available for Gene Families for TARSL2 Gene

Function for TARSL2 Gene

Molecular function for TARSL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Enzyme Numbers (IUBMB) for TARSL2 Gene

Gene Ontology (GO) - Molecular Function for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004829 threonine-tRNA ligase activity IBA,IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TARSL2: view

Animal Model Products

CRISPR Products

miRNA for TARSL2 Gene

miRTarBase miRNAs that target TARSL2

Inhibitory RNA Products

Clone Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TARSL2 Gene

Localization for TARSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARSL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TARSL2 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA,IEA --
genes like me logo Genes that share ontologies with TARSL2: view

Pathways & Interactions for TARSL2 Gene

SuperPathways for TARSL2 Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with TARSL2: view

Pathways by source for TARSL2 Gene

1 KEGG pathway for TARSL2 Gene

Gene Ontology (GO) - Biological Process for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation IEA --
GO:0006435 threonyl-tRNA aminoacylation IBA,IEA --
GO:0008150 biological_process ND --
GO:0043039 tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with TARSL2: view

No data available for SIGNOR curated interactions for TARSL2 Gene

Drugs & Compounds for TARSL2 Gene

(4) Drugs for TARSL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
L-Threonine Approved Nutra 0

(1) Additional Compounds for TARSL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with TARSL2: view

Transcripts for TARSL2 Gene

Unigene Clusters for TARSL2 Gene

Threonyl-tRNA synthetase-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TARSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - - -
SP2: - - - - - - -
SP3: - - -
SP4:

Relevant External Links for TARSL2 Gene

GeneLoc Exon Structure for
TARSL2
ECgene alternative splicing isoforms for
TARSL2

Expression for TARSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TARSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TARSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Rectum (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TARSL2 Gene



Protein tissue co-expression partners for TARSL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TARSL2 Gene:

TARSL2

SOURCE GeneReport for Unigene cluster for TARSL2 Gene:

Hs.657163

Evidence on tissue expression from TISSUES for TARSL2 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TARSL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TARSL2 Gene

Orthologs for TARSL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TARSL2 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TARSL2 34 35
  • 88.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TARSL2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tarsl2 34 16 35
  • 85.18 (n)
cow
(Bos Taurus)
Mammalia TARSL2 34 35
  • 83.17 (n)
rat
(Rattus norvegicus)
Mammalia Tarsl2 34
  • 82.81 (n)
oppossum
(Monodelphis domestica)
Mammalia TARSL2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TARSL2 34 35
  • 75.83 (n)
lizard
(Anolis carolinensis)
Reptilia TARSL2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tarsl2 34
  • 71.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18083 34
zebrafish
(Danio rerio)
Actinopterygii CABZ01081822.1 35
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 35
  • 63 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tars-1 35
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 35
  • 53 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.2547 34
wheat
(Triticum aestivum)
Liliopsida Ta.3509 34
corn
(Zea mays)
Liliopsida Zm.6559 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 62 (a)
ManyToMany
Species where no ortholog for TARSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TARSL2 Gene

ENSEMBL:
Gene Tree for TARSL2 (if available)
TreeFam:
Gene Tree for TARSL2 (if available)

Paralogs for TARSL2 Gene

Paralogs for TARSL2 Gene

(3) SIMAP similar genes for TARSL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TARSL2: view

Variants for TARSL2 Gene

Sequence variations from dbSNP and Humsavar for TARSL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000009398 -- 101,726,213(+) AACTC(A/C)CACTG upstream-variant-2KB
rs1000023609 -- 101,716,015(+) TTCCT(C/T)TGCCT intron-variant
rs1000034446 -- 101,716,104(+) CCCTG(C/T)CTTCT intron-variant
rs1000072527 -- 101,715,787(+) TCTTG(C/T)GACTT intron-variant
rs1000122567 -- 101,715,051(+) TTTTT(-/G)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TARSL2 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV gain 17911159
dgv2675n100 CNV gain 25217958
dgv2677n100 CNV loss 25217958
dgv2679n100 CNV loss 25217958
dgv2680n100 CNV gain 25217958
dgv2681n100 CNV gain 25217958
dgv2682n100 CNV gain 25217958
dgv2683n100 CNV gain 25217958
dgv4792n54 CNV gain 21841781
dgv4800n54 CNV gain 21841781
dgv4801n54 CNV gain 21841781
dgv764e212 CNV gain 25503493
dgv765e212 CNV gain 25503493
esv1005771 CNV deletion 20482838
esv1418059 CNV deletion 17803354
esv2660030 CNV deletion 23128226
esv2667525 CNV deletion 23128226
esv2761688 CNV gain+loss 21179565
esv29627 CNV loss 19812545
esv3057 CNV loss 18987735
esv3581879 CNV loss 25503493
esv3581880 CNV loss 25503493
esv3581886 CNV loss 25503493
esv3637519 CNV gain 21293372
esv3637520 CNV gain 21293372
esv3637521 CNV loss 21293372
esv3637522 CNV gain 21293372
esv3637523 CNV loss 21293372
esv3892746 CNV gain 25118596
esv3892749 CNV gain 25118596
esv3892750 CNV gain 25118596
nsv1041586 CNV gain 25217958
nsv1046557 CNV gain 25217958
nsv1051784 CNV gain 25217958
nsv1140135 CNV insertion 24896259
nsv1693 CNV insertion 18451855
nsv457293 CNV gain 19166990
nsv477753 CNV novel sequence insertion 20440878
nsv521896 CNV gain 19592680
nsv523315 CNV gain 19592680
nsv528761 CNV gain 19592680
nsv570905 CNV gain 21841781
nsv570906 CNV loss 21841781
nsv827470 CNV gain 20364138

Variation tolerance for TARSL2 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TARSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TARSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARSL2 Gene

Disorders for TARSL2 Gene

Relevant External Links for TARSL2

Genetic Association Database (GAD)
TARSL2
Human Genome Epidemiology (HuGE) Navigator
TARSL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TARSL2

No disorders were found for TARSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TARSL2 Gene

Publications for TARSL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for TARSL2 Gene

Sources for TARSL2 Gene

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