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Aliases & Descriptions for TARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.3 3 | | FLJ12528 1, 2 | | OTTHUMP00000014939 2 | | TARSL1 2, 3 | | ThrRS 3 |
| | | Descriptions |
|---|
| Threonine--tRNA ligase 3 | | Threonyl-tRNA synthetase-like 1 1, 2, 3 | | threonine tRNA ligase 2, mitochondrial 2 | | threonyl-tRNA synthetase 2, mitochondrial 2 | | threonyl-tRNA synthetase 2, mitochondrial (putative) 2 |
|
| | Search outside databases for aliases for TARS2 gene |
Summaries for TARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for TARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.2TARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P148727:
(about GC identifiers)
Start:
|
148,726,517 bp from pter |
End:
|
148,746,702 bp from pter |
Size:
|
20,186 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for TARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYTM_HUMAN, Q9BW92 (See
protein sequence)Recommended Name: Threonyl-tRNA synthetase, mitochondrial precursor Size: 718 amino acids; 81036 Da
Subcellular location: Mitochondrion matrix (By similarity)
Secondary accessions: Q53GW7 Q96I50REFSEQ proteins: NP_079426.2
ENSEMBL proteins: ENSP00000358060 ENSP00000358050 ENSP00000358049 ENSP00000358048 ENSP00000358047
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TARS2: Assays for TARS2: | Protein
Domains/ Families for TARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BW92
ProtoNet protein and cluster: Q9BW92 3 Blocks protein families: IPB002320 Threonyl-tRNA synthetase signature IPB004095 TGS domain IPB004154 Anticodon binding domain
UniProtKB/Swiss-Prot: SYTM_HUMAN, Q9BW92Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family | Gene Function for TARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025150
Applied Biosystems Silencer® siRNAs for TARS2
Sigma-Aldrich siRNA for TARS2  Sigma-Aldrich shRNA for TARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025150                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_025150                                  untagged cDNA clone in CMV expression vector: NM_025150 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025150
UniProtKB/Swiss-Prot: SYTM_HUMAN, Q9BW92Catalytic activity: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)Enzyme Number (IUBMB): EC 6.1.1.3 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for TARS2 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for TARS2 (ENSP000003580603) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006435 | threonyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for TARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TARS2
|
Transcripts for TARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025150
Sigma-Aldrich siRNA for TARS2  Sigma-Aldrich shRNA for TARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_025150 REFSEQ mRNAs for TARS2 gene: NM_025150.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_025150               OriGene GFP tagged cDNA clone in CMV expression vector: NM_025150                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_025150                                  untagged cDNA clone in CMV expression vector: NM_025150  Additional cDNA sequence: AK022590.1 AK222814.1 AK225368.1 AK298773.1 AK315507.1 AL512732.1 AY450558.1 BC000541.2 BC007824.2 BC009997.2 12 DOTS entries: DT.308463 DT.100784793 DT.100784790 DT.102828443 DT.121447939 DT.121447959 DT.121447964 DT.121447969 DT.40308418 DT.92015346 DT.95089088 DT.40225237 24/165 AceView cDNA sequences (see all 165
):CF128265 NM_025150 BU538656 BC009997 BU155618 BE730976 BQ303296 BM837737 AL520830 AA353210 CF141964 BQ940615 CK430228 BC007824 AA552157 BM561906 BX281571 BM974316 CA426625 BC000541 BU543143 AW627780 BM770498 BQ230411 Unigene Cluster for TARS2: Threonyl-tRNA synthetase 2, mitochondrial (putative) Hs.288974 [show with all ESTs]Unigene Representative Sequence: BC007824
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TARS2 (see all 14
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   |
| ExUns: | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TARS2
5 Ensembl transcripts including schematic representations: ENST00000369064
ENST00000369054
ENST00000369053
ENST00000369052
ENST00000369051
|
Expression for TARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TARS2
1 / 2 5 probe-sets matching TARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTGCTCTCC
SOURCE GeneReport for Unigene cluster: Hs.288974
|
Orthologs for TARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TARS2 gene from 5 species
About this table Species with no ortholog for TARS2
ENSEMBL Gene Tree for TARS2 | Paralogs for TARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TARS2 gene
- TARSL22 MRPL392 TARS2
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for TARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TARS2 (up to first 250kb)
|
Disorders & Mutations for TARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612805
Human Genome Epidemiology Navigator: TARS2 (1 document)
|
Medical News for TARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for TARS2 gene: |
Search for TARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TARS2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TARS2:

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| | | | Search Tocris compounds for TARS2 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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