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Aliases for TARS2 Gene

Aliases for TARS2 Gene

  • Threonyl-TRNA Synthetase 2, Mitochondrial (Putative) 2 3
  • Threonyl-TRNA Synthetase-Like 1 2 3 4
  • EC 6.1.1.3 4 64
  • TARSL1 3 4
  • ThrRS 3 4
  • Threonine--TRNA Ligase, Mitochondrial 3
  • Threonyl-TRNA Synthetase 4
  • Threonine TRNA Ligase 2 2
  • Mitochondrial 2
  • COXPD21 3

External Ids for TARS2 Gene

Previous Symbols for TARS2 Gene

  • TARSL1

Summaries for TARS2 Gene

Entrez Gene Summary for TARS2 Gene

  • This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]

GeneCards Summary for TARS2 Gene

TARS2 (Threonyl-TRNA Synthetase 2, Mitochondrial (Putative)) is a Protein Coding gene. Diseases associated with TARS2 include combined oxidative phosphorylation deficiency 21. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include threonine-tRNA ligase activity. An important paralog of this gene is TARS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARS2 Gene

Genomics for TARS2 Gene

Genomic Location for TARS2 Gene

Start:
150,487,364 bp from pter
End:
150,507,609 bp from pter
Size:
20,246 bases
Orientation:
Plus strand

Genomic View for TARS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TARS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARS2 Gene

Regulatory Elements for TARS2 Gene

Proteins for TARS2 Gene

  • Protein details for TARS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW92-SYTM_HUMAN
    Recommended name:
    Threonine--tRNA ligase, mitochondrial
    Protein Accession:
    Q9BW92
    Secondary Accessions:
    • Q53GW7
    • Q96I50
    • Q9H9V2

    Protein attributes for TARS2 Gene

    Size:
    718 amino acids
    Molecular mass:
    81036 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TARS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARS2 Gene

Proteomics data for TARS2 Gene at MOPED

Selected DME Specific Peptides for TARS2 Gene

Post-translational modifications for TARS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys169, Lys215, and Lys572

Other Protein References for TARS2 Gene

Domains for TARS2 Gene

Gene Families for TARS2 Gene

HGNC:
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

UniProtKB/Swiss-Prot:

SYTM_HUMAN
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.:
    • Q9BW92
genes like me logo Genes that share domains with TARS2: view

Function for TARS2 Gene

Molecular function for TARS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

Enzyme Numbers (IUBMB) for TARS2 Gene

Gene Ontology (GO) - Molecular Function for TARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003674 molecular_function ND --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004829 threonine-tRNA ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TARS2: view

miRNA for TARS2 Gene

miRTarBase miRNAs that target TARS2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TARS2 Gene

Localization for TARS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARS2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARS2 Gene COMPARTMENTS Subcellular localization image for TARS2 gene
Compartment Confidence
mitochondrion 3
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with TARS2: view

Pathways for TARS2 Gene

genes like me logo Genes that share pathways with TARS2: view

Pathways by source for TARS2 Gene

1 KEGG pathway for TARS2 Gene

Gene Ontology (GO) - Biological Process for TARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006435 threonyl-tRNA aminoacylation --
GO:0008152 metabolic process --
GO:0010467 gene expression TAS --
GO:0043039 tRNA aminoacylation --
genes like me logo Genes that share ontologies with TARS2: view

Compounds for TARS2 Gene

(5) HMDB Compounds for TARS2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Threonine
  • (2S,3R)-(-)-Threonine
72-19-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for TARS2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Threonine
  • (S)-Threonine
72-19-5 target
genes like me logo Genes that share compounds with TARS2: view

Transcripts for TARS2 Gene

Unigene Clusters for TARS2 Gene

Threonyl-tRNA synthetase 2, mitochondrial (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TARS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - -
SP9: - - -
SP10:
SP11: -
SP12:
SP13:
SP14: - - - -

ExUns: 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TARS2 Gene

GeneLoc Exon Structure for
TARS2
ECgene alternative splicing isoforms for
TARS2

Expression for TARS2 Gene

mRNA expression in normal human tissues for TARS2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARS2 Gene

SOURCE GeneReport for Unigene cluster for TARS2 Gene Hs.288974

genes like me logo Genes that share expressions with TARS2: view

Orthologs for TARS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TARS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TARS2 36
  • 99.81 (n)
  • 99.86 (a)
TARS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TARS2 36
  • 88.25 (n)
  • 87.88 (a)
TARS2 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARS2 36
  • 88.07 (n)
  • 87.33 (a)
TARS2 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tars2 36
  • 83.75 (n)
  • 84.26 (a)
Tars2 16
Tars2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TARS2 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tars2 36
  • 83.38 (n)
  • 83.15 (a)
chicken
(Gallus gallus)
Aves TARS2 36
  • 62.54 (n)
  • 60.6 (a)
TARS2 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TARS2 37
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TARS2 37
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 37
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tars-1 37
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 37
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
ManyToMany
Species with no ortholog for TARS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TARS2 Gene

ENSEMBL:
Gene Tree for TARS2 (if available)
TreeFam:
Gene Tree for TARS2 (if available)

Paralogs for TARS2 Gene

Paralogs for TARS2 Gene

Selected SIMAP similar genes for TARS2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TARS2 Gene

genes like me logo Genes that share paralogs with TARS2: view

Variants for TARS2 Gene

Sequence variations from dbSNP and Humsavar for TARS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs871527 -- 150,489,612(+) AAGAC(C/G)AAACA intron-variant
rs953127 -- 150,496,780(+) TTGAG(G/T)TGACC intron-variant
rs1343965 -- 150,496,366(+) GTGGG(A/G)TTGTT intron-variant
rs2275245 -- 150,487,872(-) GGAGG(A/G)GTCGA reference, synonymous-codon, nc-transcript-variant
rs2275246 -- 150,487,692(-) CAGAG(C/T)CCCCC intron-variant

Relevant External Links for TARS2 Gene

HapMap Linkage Disequilibrium report
TARS2
Human Gene Mutation Database (HGMD)
TARS2

No data available for Structural Variations from Database of Genomic Variants (DGV) for TARS2 Gene

Disorders for TARS2 Gene

UniProtKB/Swiss-Prot

SYTM_HUMAN
  • Combined oxidative phosphorylation deficiency 21 (COXPD21) [MIM:615918]: A mitochondrial disorder characterized by a lethal encephalomyopathy. Shortly after birth, affected individuals manifest axial hypotonia, limb hypertonia, psychomotor delay, and increased serum lactate. Additional features include subsarcolemmal lipofuscin-positive deposits in muscle, cerebral spongiosis, and hepatic steatosis. {ECO:0000269 PubMed:24827421}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TARS2 Gene

Relevant External Links for TARS2

Genetic Association Database (GAD)
TARS2
Human Genome Epidemiology (HuGE) Navigator
TARS2
genes like me logo Genes that share disorders with TARS2: view

Publications for TARS2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PMID: 15779907) Bonnefond L. … Sissler M. (Biochemistry 2005) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E. … Dekker J.M. (Eur. J. Hum. Genet. 2009) 3 49
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for TARS2 Gene

Sources for TARS2 Gene

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