Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TARS2 Gene

protein-coding   GIFtS: 59
GCID: GC01P150459

Threonyl-TRNA Synthetase 2, Mitochondrial (Putative)

(Previous name: threonyl-tRNA synthetase-like 1)
(Previous symbol: TARSL1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Threonyl-TRNA Synthetase 2, Mitochondrial (Putative)1 2     Threonine TRNA Ligase 21
Threonyl-TRNA Synthetase-Like 11 2 3     thrRS2
TARSL11 2 3     Threonine--TRNA Ligase, Mitochondrial2
EC 6.1.1.33 8     ThrRS3
mitochondrial1     Threonyl-TRNA Synthetase3

External Ids:    HGNC: 307401   Entrez Gene: 802222   Ensembl: ENSG000001433747   OMIM: 6128055   UniProtKB: Q9BW923   

Export aliases for TARS2 gene to outside databases

Previous GC identifers: GC01P148727 GC01P121838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TARS2 Gene:
This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a
mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related
pseudogene has been identified on chromosome 4. (provided by RefSeq, Dec 2012)

GeneCards Summary for TARS2 Gene:
TARS2 (threonyl-tRNA synthetase 2, mitochondrial (putative)) is a protein-coding gene. Diseases associated with TARS2 include myositis, and pneumonia. GO annotations related to this gene include threonine-tRNA ligase activity. An important paralog of this gene is TARSL2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TARS2 gene promoter:
         SRF   Elk-1   C/EBPbeta   GATA-3   Pbx1a   Pax-6   SRF (504 AA)   HNF-3beta   Gfi-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTARS2 promoter sequence
   Search Chromatin IP Primers for TARS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

TARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150459:  view genomic region     (about GC identifiers)

Start:
150,459,887 bp from pter      End:
150,480,078 bp from pter
Size:
20,192 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYTM_HUMAN, Q9BW92 (See protein sequence)
Recommended Name: Threonine--tRNA ligase, mitochondrial precursor  
Size: 718 amino acids; 81036 Da
Secondary accessions: Q53GW7 Q96I50

Explore the universe of human proteins at neXtProt for TARS2: NX_Q9BW92

Explore proteomics data for TARS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys169, Lys215, Lys572
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TARS2 (Q9BW92) (see all 11)
     TIQLDFQ  WEQSGHW  QDDAHIF  DDAHIFC 


    See TARS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258824.1  NP_001258825.1  NP_079426.2  

    ENSEMBL proteins: 
     ENSP00000358050   ENSP00000358060   ENSP00000475847   ENSP00000358047   ENSP00000475551  
     ENSP00000415002  
    Reactome Protein details: Q9BW92

    TARS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TARS2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TARS2
    GenScript Custom Purified and Recombinant Proteins Services for TARS2
    Novus Biologicals TARS2 Protein
    Novus Biologicals TARS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TARS2

    TARS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TARS2
    Novus Biologicals TARS2 Antibodies
    Abcam antibodies for TARS2
    Cloud-Clone Corp. Antibodies for TARS2
    ThermoFisher Antibodies for TARS2
    LSBio Antibodies in human, mouse, rat for TARS2

    TARS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TARS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TARS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TARS2
    Cloud-Clone Corp. CLIAs for TARS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    Selected InterPro protein domains (see all 9):
     IPR018163 Thr/Ala-tRNA-synth_IIc_edit
     IPR002314 aa-tRNA-synt_IIb_cons-dom
     IPR002320 Thr-tRNA-ligase_IIa
     IPR012675 Beta-grasp_dom
     IPR006195 aa-tRNA-synth_II

    Graphical View of Domain Structure for InterPro Entry Q9BW92

    ProtoNet protein and cluster: Q9BW92

    3 Blocks protein domains:
    IPB002320 Threonyl-tRNA synthetase signature
    IPB004095 TGS domain
    IPB004154 Anticodon binding domain


    UniProtKB/Swiss-Prot: SYTM_HUMAN, Q9BW92
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    TARS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTM_HUMAN, Q9BW92
    Catalytic activity: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

         Enzyme Number (IUBMB): EC 6.1.1.31 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003674molecular_function ND--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004829threonine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    TARS2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TARS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TARS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TARS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TARS2:
    hsa-mir-484 (MIRT041757)

    Block miRNA regulation of human, mouse, rat TARS2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TARS2:
    hsa-miR-148b*
    SwitchGear 3'UTR luciferase reporter plasmidTARS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TARS2
    Predesigned siRNA for gene silencing in human, mouse, rat TARS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TARS2

    Clone
    Products:
         
    OriGene clones in human, mouse for TARS2 (see all 9)
    OriGene ORF clones in mouse, rat for TARS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TARS2 (NM_025150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TARS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TARS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYTM_HUMAN, Q9BW92: Mitochondrion matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IEA--

    TARS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TARS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.52
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TARS2
        Mitochondrial tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for TARS2):
        Aminoacyl-tRNA biosynthesis


    TARS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TARS2
    Interactions:

        Search GeneGlobe Interaction Network for TARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TARS2 (Q9BW922, 3 ENSP000003580604) via UniProtKB, MINT, STRING, and/or I2D (see all 270)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    EIF4A2Q142403, ENSP000003263814I2D: score=1 STRING: ENSP00000326381
    HSPD1P108092, ENSP000003400194MINT-8079030 STRING: ENSP00000340019
    ATG4CQ96DT63I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006435threonyl-tRNA aminoacylation ----
    GO:0010467gene expression TAS--
    GO:0043039tRNA aminoacylation ----
    GO:0070159mitochondrial threonyl-tRNA aminoacylation TAS15779907

    TARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TARS2 (SYTM)

    5 HMDB Compounds for TARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Threonine(2S,3R)-(-)-Threonine (see all 21)72-19-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for TARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Threonine(S)-Threonine (see all 6)72-19-5target--17644600



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TARS2 gene (3 alternative transcripts): 
    NM_001271895.1  NM_001271896.1  NM_025150.4  

    Unigene Cluster for TARS2:

    Threonyl-tRNA synthetase 2, mitochondrial (putative)
    Hs.288974  [show with all ESTs]
    Unigene Representative Sequence: NM_025150
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369054 ENST00000369064(uc010pcd.1 uc001euq.3 uc001eur.3 uc009wlt.3 uc009wls.3)
    ENST00000606933 ENST00000369053 ENST00000369051 ENST00000479372 ENST00000467982
    ENST00000466989 ENST00000480070 ENST00000463555 ENST00000460794 ENST00000462578
    ENST00000483046 ENST00000438568
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TARS2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TARS2:
    hsa-miR-148b*
    SwitchGear 3'UTR luciferase reporter plasmidTARS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TARS2
    Predesigned siRNA for gene silencing in human, mouse, rat TARS2
    Clone
    Products:
         
    OriGene clones in human, mouse for TARS2 (see all 9)
    OriGene ORF clones in mouse, rat for TARS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TARS2 (NM_025150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TARS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARS2
      QuantiTect SYBR Green Assays in human, mouse, rat TARS2
      QuantiFast Probe-based Assays in human, mouse, rat TARS2

    Additional mRNA sequence: 

    AK022590.1 AK222814.1 AK225368.1 AK298773.1 AK315507.1 AL512732.1 AY450558.1 BC000541.2 
    BC007824.2 BC009997.2 NR_073513.1 NR_073514.1 

    11 DOTS entries:

    DT.308463  DT.100784793  DT.100784790  DT.102828443  DT.121447939  DT.121447959  DT.121447964  DT.121447969 
    DT.40308418  DT.40225237  DT.95089088 

    Selected AceView cDNA sequences (see all 165):

    AA552157 BU543143 BU184724 BQ230411 BM561906 AL520830 BU155618 CF141964 
    BM974316 BQ940615 BC007824 BP372834 BU538656 BC000541 BX281571 CA426625 
    BQ878504 NM_025150 BG177552 BM474278 BQ303296 BM834367 BI087779 BG472361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TARS2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^
    SP1:                                -           -                                         -     -     -                                                         
    SP2:                                -           -                                   -     -     -     -     -     -     -     -     -     -                     
    SP3:                                -           -                                         -     -     -                 -     -                                 
    SP4:                                                                                -     -     -     -                 -     -     -     -                     
    SP5:                                                                                      -     -     -                 -     -     -     -                     

    ExUns: 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCTCTCC
    TARS2 Expression
    About this image

    TARS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TARS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288974
        Custom PCR Arrays for TARS2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TARS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARS2
    QuantiTect SYBR Green Assays in human, mouse, rat TARS2
    QuantiFast Probe-based Assays in human, mouse, rat TARS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TARS2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tars21 , 5 threonyl-tRNA synthetase 2, mitochondrial (putative)1, 5 83.75(n)1
    84.26(a)1
      3 (40.93 cM)5
    718071  NM_027931.31  NP_082207.21 
     957399765 
    chicken
    (Gallus gallus)
    Aves TARS21 threonyl-tRNA synthetase 2, mitochondrial (putative) 62.54(n)
    60.6(a)
      770407  XM_001233745.3  XP_001233746.3 
    lizard
    (Anolis carolinensis)
    Reptilia TARS26
    threonyl-tRNA synthetase 2, mitochondrial (putativ...
    59(a)
    1 ↔ 1
    GL343802.1(115686-171078)
    zebrafish
    (Danio rerio)
    Actinopterygii TARS26
    threonyl-tRNA synthetase 2, mitochondrial (putativ...
    56(a)
    1 ↔ 1
    16(1249544-1263364) ENSDARG00000075385
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-thr6
    Threonyl-tRNA synthetase
    47(a)
    many ↔ many
    2L(12103734-12106894)
    worm
    (Caenorhabditis elegans)
    Secernentea tars-16
    Protein TARS-1, isoform b (tars-1) mRNA, complete ...
    46(a)
    1 → many
    II(11691326-11695657) WBGene00006617
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes THS16
    Threonyl-tRNA synthetase, essential cytoplasmic pr...
    44(a)
    1 → many
    IX(212499-214703) YIL078W


    ENSEMBL Gene Tree for TARS2 (if available)
    TreeFam Gene Tree for TARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TARS2 gene
    TARSL22  MRPL392  TARS2  
    3 SIMAP similar genes for TARS2 using alignment to 7 protein entries:     SYTM_HUMAN (see all proteins):
    DKFZp667F1511    TARS    TARSL2

    TARS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TARS2
    PGOHUM00000245702


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TARS2 (see all 518)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469297441,2
    --121836013(+) TCATAC/GTTTAC 5 -- us2k10--------
    rs1378559621,2
    --121836016(+) TACTTC/TACTAC 5 -- us2k10--------
    rs38205441,2
    C,F,A--150457876(-) CTTTAT/ACCTTT 5 -- us2k1 trp36Minor allele frequency- A:0.30NA EA 384
    rs1434258691,2
    C--150457992(+) TGGGAA/GCAAAC 5 -- us2k10--------
    rs49709641,2
    C,F,A,H--150458029(+) AAAGAA/GAACCA 5 -- us2k117Minor allele frequency- N:0.00EA NA NS WA CSA 1001
    rs49709221,2
    C,F,A,H--150458094(+) TCTGTA/CAGATT 5 -- us2k121Minor allele frequency- C:0.47NS EA WA NA CSA 2345
    rs1923958031,2
    --150458285(+) CTACTC/TGGGAG 5 -- us2k10--------
    rs1468946501,2
    C--150458335(+) GTTGCC/GGTAAG 5 -- us2k10--------
    rs1389550711,2
    --150458482(+) AGATTA/CTTGAT 5 -- us2k10--------
    rs1839154521,2
    --150458567(+) ATCTCA/GGCTCA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for TARS2 (150459887 - 150480078 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TARS2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TARS2
    DNA2.0 Custom Variant and Variant Library Synthesis for TARS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612805    OMIM disorders: --

    4 diseases for TARS2:    About MalaCards
    myositis    pneumonia    diabetes mellitus    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for TARS2:
    Myositis

    TARS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TARS2
    Human Genome Epidemiology (HuGE) Navigator: TARS2 (2 documents)

    Export disorders for TARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TARS2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1, 4 Reiling E....Dekker J.M. (Eur. J. Hum. Genet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 2 Bonnefond L....Sissler M. (Biochemistry 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80222 HGNC: 30740 AceView: FLJ12528 Ensembl:ENSG00000143374 euGenes: HUgn80222
    ECgene: TARS2 Kegg: 80222 H-InvDB: TARS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TARS2 gene:
    Search GeneIP for patents involving TARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TARS2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TARS2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TARS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TARS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TARS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TARS2   OriGene Custom Protein Services for TARS2  

     
     
     Block miRNA regulation of human, mouse, rat TARS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TARS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TARS2 Predesigned siRNA for gene silencing in human, mouse, rat TARS2
     QuantiFast Probe-based Assays in human, mouse, rat TARS2 QuantiTect SYBR Green Assays in human, mouse, rat TARS2
     Custom PCR Arrays for TARS2 Search Chromatin IP Primers for TARS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARS2  Search GeneGlobe Interaction Network for TARS2
     Regulatory tfbs in TARS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TARS2 GenScript cDNA clones with any tag delivered in your preferred vector for TARS2
     GenScript Custom Assay Services for TARS2 GenScript Custom overexpressing Cell Line Services for TARS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TARS2 (SYTM)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TARS2 antibodies
     TARS2 proteins
     TARS2 lysates
     Antibodies for TARS2
     See all of Abcam's Antibodies, Kits and Proteins for TARS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TARS2
     Antibodies for TARS2
     ELISAs for TARS2
     CLIAs for TARS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TARS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARS2
     SwitchGear 3'UTR luciferase reporter plasmids for TARS2
     SwitchGear Promoter luciferase reporter plasmids for TARS2
     ThermoFisher Antibodies for TARS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TARS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TARS2
     LSBio Antibodies in human, mouse, rat for TARS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TARS2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4