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Aliases & Descriptions for TARS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.3 3 | | MGC9344 2 | | ThrRS 2, 3 |
| | | Descriptions |
|---|
| Threonine--tRNA ligase 2, 3 | | threonine tRNA ligase 1, cytoplasmic 2 | | threonyl-tRNA synthetase 2 |
|
| | Search outside databases for aliases for TARS genePrevious GC identifers: GC05U990056 GC05P033887 GC05P033440 GC05P033486 |
Summaries for TARS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq] Gene Wiki entry for TARS |
Genomic Location for TARS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TARS gene 
Entrez Gene cytogenetic band: 5p13.2 Ensembl cytogenetic band: 5p13.3 HGNC cytogenetic band: 5p13.2TARS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P033476:
(about GC identifiers)
Start:
|
33,476,655 bp from pter |
End:
|
33,503,953 bp from pter |
Size:
|
27,299 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000005.8 NT_006576.15
| Proteins for TARS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYTC_HUMAN, P26639 (See
protein sequence)Recommended Name: Threonyl-tRNA synthetase, cytoplasmic Size: 723 amino acids; 83435 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :1WWT (3D)
 
Secondary accessions: Q96FP5 Q9BWA6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_689508.3
ENSEMBL proteins: ENSP00000265112
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for TARS: Assays for TARS: | Protein
Domains/ Families for TARS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P26639
ProtoNet protein and cluster: P26639 3 Blocks protein families: IPB002320 Threonyl-tRNA synthetase signature IPB004095 TGS domain IPB004154 Anticodon binding domain
UniProtKB/Swiss-Prot: SYTC_HUMAN, P26639Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family | Gene Function for TARS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152295
Applied Biosystems Silencer® siRNAs for TARS
Sigma-Aldrich siRNA for TARS  Sigma-Aldrich shRNA for TARS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152295                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152295                                  untagged cDNA clone in CMV expression vector: NM_152295 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003191
UniProtKB/Swiss-Prot: SYTC_HUMAN, P26639Catalytic activity: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)Enzyme Number (IUBMB): EC 6.1.1.3 Genatlas biochemistry entry for TARS:threonyl-tRNA synthetase5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for TARS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for TARS (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for TARS 
5/184 Interacting proteins for TARS (P266391, 2) via UniProtKB, MINT, and/or STRING (see all 184
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006435 | threonyl-tRNA aminoacylation |
NAS | 2033077 | About this table
|
Drugs & Compounds for TARS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TARS 5 Novoseek chemical compound relationships for TARS gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| trna(thr) |
95.82 |
1 |
1567450 (1) |
| anticodon |
73.35 |
4 |
1280807 (2), 1567450 (1), 2109304 (1) |
| trna |
70.60 |
15 |
11136973 (2), 15525511 (2), 1280807 (2), 12554667 (1) (see all 6) |
| threonine |
54.22 |
6 |
14563161 (1), 15525511 (1), 2109304 (1), 10881191 (1) |
| zinc |
27.92 |
4 |
10881191 (2), 11136973 (1), 11732604 (1) |
About this table
|
Transcripts for TARS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152295
Sigma-Aldrich siRNA for TARS  Sigma-Aldrich shRNA for TARS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_152295 REFSEQ mRNAs for TARS gene: NM_152295.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_152295               OriGene GFP tagged cDNA clone in CMV expression vector: NM_152295                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152295                                  untagged cDNA clone in CMV expression vector: NM_152295  Additional cDNA sequence: AK095852.1 AK222804.1 AK292346.1 AK293620.1 AK296783.1 AK308342.1 AK311361.1 AK315713.1 BC000517.2 BC003699.1 BC010578.1 BC088355.1 CR598000.1 M63180.1 17 DOTS entries: DT.446382 DT.101973743 DT.91683773 DT.100880984 DT.100030096 DT.100880994 DT.120880672 DT.107088 DT.120880671 DT.87046925 DT.100880983 DT.100880991 DT.100880993 DT.100880995 DT.102827096 DT.120880657 DT.75107215 24/513 AceView cDNA sequences (see all 513
):BQ213220 BM785600 BQ653277 BC010578 BE297604 BG109208 BP872718 BQ925253 CN485124 AI933590 AU124418 BM468797 AI539648 AA312456 AA496803 AA470392 BF969946 CR598000 BP873604 CA439270 CA420958 AK095852 AI753151 AA309110
highest scoring ESTs for TARS:M63180 AA047555 AA047615 AA047687 AA112293 AA112550 AA158015 AA160996 AA190555 AA224574 Unigene Cluster for TARS: Threonyl-tRNA synthetase Hs.481860 [show with all ESTs]Unigene Representative Sequence: NM_152295
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TARS (see all 10
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TARS
1 Ensembl transcript including schematic representation: ENST00000265112
|
Expression for TARS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TARS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TARS
1 / 2 / 3 3 probe-sets matching TARS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCAGACATTG
SOURCE GeneReport for Unigene cluster: Hs.481860
Expression variation in blood from EXPOLDB for TARS |
Orthologs for TARS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TARS gene from 5/25 species (see all 25
)
About this table Species with no ortholog for TARS
ENSEMBL Gene Tree for TARS | Paralogs for TARS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TARS gene
- TARS22 TARSL22 MRPL392
|
SNPs/Variants for TARS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TARS (up to first 250kb)
|
Disorders & Mutations for TARS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 187790
5 Novoseek disease relationships for TARS gene
About this table
|
Medical News for TARS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TARS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/44 PubMed articles for TARS gene (see all 44
): |
Search for TARS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TARS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TARS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TARS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TARS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TARS:

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| | Recombinant Proteins (TARS) | | Antibodies (TARS) |
| | | Search Tocris compounds for TARS |
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Incremental update: 13 Oct 2009
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