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TARS Gene

protein-coding   GIFtS: 69
GCID: GC05P033440

Threonyl-TRNA Synthetase

  See TARS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Threonyl-TRNA Synthetase1 2 3     Threonine TRNA Ligase 11
ThrRS2 3     Threonine TRNA Ligase 1, Cytoplasmic2
EC 6.1.1.33 8     Threonine--TRNA Ligase, Cytoplasmic2
cytoplasmic1     Threonyl-TRNA Synthetase, Cytoplasmic2

External Ids:    HGNC: 115721   Entrez Gene: 68972   Ensembl: ENSG000001134077   OMIM: 1877905   UniProtKB: P266393   

Export aliases for TARS gene to outside databases

Previous GC identifers: GC05U990056 GC05P033887 GC05P033486 GC05P033476


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the
class-II aminoacyl-tRNA synthetase family (provided by RefSeq, Jul 2008)

GeneCards Summary for TARS Gene:
TARS (threonyl-tRNA synthetase) is a protein-coding gene. Diseases associated with TARS include antisynthetase syndrome. GO annotations related to this gene include protein homodimerization activity and threonine-tRNA ligase activity. An important paralog of this gene is TARS2.

Gene Wiki entry for TARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TARS gene promoter:
         STAT5B   STAT4   STAT1beta   STAT6   STAT5A   AP-4   LCR-F1   YY1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTARS promoter sequence
   Search Chromatin IP Primers for TARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.2

TARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARS gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P033440:  view genomic region     (about GC identifiers)

Start:
33,440,802 bp from pter      End:
33,469,644 bp from pter
Size:
28,843 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYTC_HUMAN, P26639 (See protein sequence)
Recommended Name: Threonine--tRNA ligase, cytoplasmic  
Size: 723 amino acids; 83435 Da
Subunit: Homodimer
Sequence caution: Sequence=AAB04939.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TARS:
1WWT (3D)        4HWT (3D)    
Secondary accessions: A8K8I1 B4DEG8 Q96FP5 Q9BWA6
Alternative splicing: 2 isoforms:  P26639-1   P26639-2   

Explore the universe of human proteins at neXtProt for TARS: NX_P26639

Explore proteomics data for TARS at MOPED

Post-translational modifications: 

  • ISGylated1
  • Ubiquitination2 at Lys65, Lys222, Lys223, Lys243, Lys279, Lys288, Lys504, Lys549, Lys611, Lys636,
                                 Lys645, Lys660, Lys681, Lys712, Lys717
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TARS (P26639) (see all 35)
     WKTTPYQ  IKDAIGR  LCYGPPI  LKPMNCP 


    See TARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001245366.1  NP_001245367.1  NP_689508.3  

    ENSEMBL proteins: 
     ENSP00000424387   ENSP00000422130   ENSP00000265112   ENSP00000427627   ENSP00000387710  
     ENSP00000420893   ENSP00000427304   ENSP00000422291   ENSP00000425524   ENSP00000422598  
     ENSP00000438469   ENSP00000394291  
    Reactome Protein details: P26639

    TARS Human Recombinant Protein Products:

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    Novus Biologicals TARS Proteins
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    Cloud-Clone Corp. Proteins for TARS

     
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    TARS Antibody Products:

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    TARS Assay Products:

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    Cloud-Clone Corp. CLIAs for TARS
    Search eBioscience for ELISAs for TARS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    Selected InterPro protein domains (see all 9):
     IPR018163 Thr/Ala-tRNA-synth_IIc_edit
     IPR002314 aa-tRNA-synt_IIb_cons-dom
     IPR002320 Thr-tRNA-ligase_IIa
     IPR012675 Beta-grasp_dom
     IPR006195 aa-tRNA-synth_II

    Graphical View of Domain Structure for InterPro Entry P26639

    ProtoNet protein and cluster: P26639

    3 Blocks protein domains:
    IPB002320 Threonyl-tRNA synthetase signature
    IPB004095 TGS domain
    IPB004154 Anticodon binding domain


    UniProtKB/Swiss-Prot: SYTC_HUMAN, P26639
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    Find genes that share domains with TARS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTC_HUMAN, P26639
    Catalytic activity: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

         Genatlas biochemistry entry for TARS:
    threonyl-tRNA synthetase

         Enzyme Number (IUBMB): EC 6.1.1.31 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004829threonine-tRNA ligase activity TAS--
    GO:0005524ATP binding IEA--
    GO:0016876ligase activity, forming aminoacyl-tRNA and related compounds ----
         
    Find genes that share ontologies with TARS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TARS:
     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TARS
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    miRNA
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    miRTarBase miRNAs that target TARS:
    hsa-mir-877-3p (MIRT037167), hsa-mir-191-5p (MIRT045807), hsa-let-7a-5p (MIRT052487)

    Block miRNA regulation of human, mouse, rat TARS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TARS:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidTARS 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TARS
    Predesigned siRNA for gene silencing in human, mouse, rat TARS

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TARS (NM_152295)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARS

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYTC_HUMAN, P26639: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS2033077
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton IDA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with TARS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TARS About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with TARS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TARS
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for TARS):
        Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TARS
    Interactions:

        GeneGlobe Interaction Network for TARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TARS (P266392, 3 ENSP000002651124) via UniProtKB, MINT, STRING, and/or I2D (see all 217)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS2033077
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006435threonyl-tRNA aminoacylation NAS2033077
    GO:0010467gene expression TAS--
    GO:0043039tRNA aminoacylation ----

    Find genes that share ontologies with TARS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TARS
      Browse compounds at ApexBio 

    Browse Tocris compounds for TARS (SYTC)

    5 HMDB Compounds for TARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Threonine(2S,3R)-(-)-Threonine (see all 21)72-19-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for TARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Threonine(S)-Threonine (see all 6)72-19-5target--9493271 15507440 17139284 17016423 12875846

    6 Novoseek inferred chemical compound relationships for TARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(thr) 95.6 1 1567450 (1)
    anticodon 72.7 4 1280807 (2), 1567450 (1), 2109304 (1)
    trna 72.4 15 11136973 (2), 15525511 (2), 1280807 (2), 12554667 (1) (see all 6)
    threonine 53.1 6 14563161 (1), 15525511 (1), 2109304 (1), 10881191 (1)
    zinc 33.1 6 10881191 (2), 11136973 (1), 11732604 (1), 19549823 (1)
    serine 23.9 2 15525511 (1)



    Find genes that share compounds with TARS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TARS gene (3 alternative transcripts): 
    NM_001258437.1  NM_001258438.1  NM_152295.4  

    Unigene Cluster for TARS:

    Threonyl-tRNA synthetase
    Hs.481860  [show with all ESTs]
    Unigene Representative Sequence: NR_047676
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502553 ENST00000514259 ENST00000265112(uc010iup.1 uc003jhy.3 uc011coc.2 uc003jhz.3 uc011cod.2)
    ENST00000502508 ENST00000508361 ENST00000455217 ENST00000507716 ENST00000509731
    ENST00000505012 ENST00000513066 ENST00000506040 ENST00000504698 ENST00000509410
    ENST00000503422 ENST00000541634 ENST00000414361
    miRNA
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    Block miRNA regulation of human, mouse, rat TARS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TARS:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidTARS 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TARS (NM_152295)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARS
      QuantiTect SYBR Green Assays in human, mouse, rat TARS
      QuantiFast Probe-based Assays in human, mouse, rat TARS

    Additional mRNA sequence: 

    AK095852.1 AK222804.1 AK292346.1 AK293620.1 AK296783.1 AK308342.1 AK311361.1 AK315713.1 
    BC000517.2 BC003699.1 BC010578.1 BC088355.1 M63180.1 NR_047676.1 NR_047677.1 NR_047678.1 

    17 DOTS entries:

    DT.446382  DT.101973743  DT.91683773  DT.100880984  DT.100030096  DT.100880994  DT.120880672  DT.120880671 
    DT.87046925  DT.100880983  DT.100880991  DT.100880993  DT.100880995  DT.102827096  DT.107088  DT.120880657 
    DT.75107215 

    Selected AceView cDNA sequences (see all 513):

    BM468797 BU527429 BP873578 BQ573732 AA573902 AA600024 CB123959 BQ653277 
    BQ030165 AA804893 BG532496 BU786090 BM792633 AA309110 BQ925253 AI915604 
    AU119805 BU164359 BM788070 AA373761 BQ288031 BU681948 BX338148 CR598000 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TARS (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
    SP1:                                                  -           -     -                                                                                       
    SP2:                                                  -           -     -     -     -                                                                           
    SP3:                                                  -           -                                                                                             
    SP4:                    -     -     -     -           -           -     -                                                                                       
    SP5:              -     -     -     -     -           -           -     -                                                                                       

    ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGACATTG
    TARS Expression
    About this image


    TARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Thyroid (Endocrine System)
    TARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481860
        Custom PCR Arrays for TARS
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TARS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TARS gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tars1 , 5 threonyl-tRNA synthetase1, 5 86.98(n)1
    95.01(a)1
      15 (5.60 cM)5
    1109601  NM_033074.31  NP_149065.21 
     113836635 
    chicken
    (Gallus gallus)
    Aves TARS1 threonyl-tRNA synthetase 79.51(n)
    89.73(a)
      427427  NM_001031447.1  NP_001026618.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.91042 Xenopus laevis transcribed sequence with moderate similarity more 79.2(n)    BQ731524.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb07c052 Transcribed sequence with moderate similarity to protein more 78.75(n)    57052295 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-thr1 , 3 threonyl-tRNA aminoacylation
    threonine-tRNA ligase3
    Threonyl-tRNA synthetase1
    73(a)3
    66.92(n)1
    75.22(a)1
      33C43
    457841  NM_080100.51  NP_524839.31 
    worm
    (Caenorhabditis elegans)
    Secernentea trs-13
    tars-11
    tars-11 63(a)3
    61.55(n)1
    64.21(a)1
      II(11691448-11694165)3
    1747901  NM_001026862.31  NP_001022033.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes THS1(YIL078W)4
    THS11
    Threonyl-tRNA synthetase, essential cytoplasmic protein4
    THS11
    59.08(n)1
    58.68(a)1
      9(212499-214703)4
    8547321, 4  NP_116578.31  NP_116578.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G268301 AT5G26830 58.18(n)
    57.75(a)
      832741  NM_122565.2  NP_198035.2 
    rice
    (Oryza sativa)
    Liliopsida Os.198422 Oryza sativa mRNA for threonyl-tRNA synthetase, partial 72.97(n)    AK070378.1 


    ENSEMBL Gene Tree for TARS (if available)
    TreeFam Gene Tree for TARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TARS gene
    TARS22  TARSL22  MRPL392  
    3 SIMAP similar genes for TARS using alignment to 11 protein entries:     SYTC_HUMAN (see all proteins):
    TARSL2    DKFZp667F1511    TARS2

    Find genes that share paralogs with TARS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TARS (see all 779)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601633321,2
    C,F--33439023(+) TTATGT/CAGAAG 6 -- us2k11Minor allele frequency- C:0.07EA 120
    rs737585521,2
    C,F--33439148(+) CCAACT/CGATCA 6 -- us2k12Minor allele frequency- C:0.20WA 120
    rs1478284881,2
    C--33439168(+) TGTGC-/ATATATA 6 -- us2k10--------
    rs608816011,2
    C--33439169(+) ATATA-/AT/TA 
            
    ATATA
    6 -- us2k10--------
    rs1470882441,2
    --33439203(+) ATATAC/TGTATG 6 -- us2k10--------
    rs68897801,2
    C--33439228(+) tgtgtA/Gtatat 6 -- us2k10--------
    rs1466166831,2
    C--33439228(+) GTGTG-/TA/   
      TATATA
    TATAT
    9 -- us2k1 cds10--------
    rs3677019141,2
    C--33439229(+) TGTGT-/TA    
       
    /TATA
    ATATA
    6 -- us2k10--------
    rs1825575241,2
    --33439245(+) ATATAC/TACACA 6 -- us2k10--------
    rs68705211,2
    C,F,A--33439251(+) acacaT/Catata 6 -- us2k11Minor allele frequency- C:0.12WA 118

    HapMap Linkage Disequilibrium report for TARS (33440802 - 33469644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471010CNV Gain18288195
    dgv699n27CNV Gain19166990
    nsv522715CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TARS
    DNA2.0 Custom Variant and Variant Library Synthesis for TARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187790    OMIM disorders: --

    1 disease for TARS:    
    About MalaCards
    antisynthetase syndrome

    2 diseases from the University of Copenhagen DISEASES database for TARS:
    Psoriasis     Myositis

    Find genes that share disorders with TARS           About GenesLikeMe

    5 Novoseek inferred disease relationships for TARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myositis 58.1 1 17043379 (1)
    polymyositis 55.8 3 7983666 (2), 12235211 (1)
    raynauds phenomenon 45.8 1 17043379 (1)
    polyarthritis 44.6 2 17043379 (1), 10606385 (1)
    dermatomyositis 41.2 2 10606385 (1), 12235211 (1)


    Export disorders for TARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TARS gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with TARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes. (PubMed id 2033077)1, 2, 9 Cruzen M.E. and Arfin S.M. (J. Biol. Chem. 1991)
    2. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Threonyl-tRNA synthetase. (PubMed id 7626230)1, 9 Freist W. and Gauss D.H. (Biol. Chem. Hoppe-Seyler 1995)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. (PubMed id 23425968)1 Williams T.F....Lounsbury K.M. (Sci Rep 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome. (PubMed id 23375620)1 Marie I....Dominique S. (Eur. J. Intern. Med. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6897 HGNC: 11572 AceView: TARS Ensembl:ENSG00000113407 euGenes: HUgn6897
    ECgene: TARS Kegg: 6897 H-InvDB: TARS

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TARS gene:
    Search GeneIP for patents involving TARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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