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Aliases for TARS Gene

Aliases for TARS Gene

  • Threonyl-TRNA Synthetase 4 2 3
  • EC 6.1.1.3 4 63
  • ThrRS 3 4
  • Threonyl-TRNA Synthetase, Cytoplasmic 3
  • Threonine TRNA Ligase 1, Cytoplasmic 3
  • Threonine TRNA Ligase 1 2
  • Cytoplasmic 2

External Ids for TARS Gene

Previous GeneCards Identifiers for TARS Gene

  • GC05U990056
  • GC05P033887
  • GC05P033440
  • GC05P033486

Summaries for TARS Gene

Entrez Gene Summary for TARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]

GeneCards Summary for TARS Gene

TARS (Threonyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with TARS include antisynthetase syndrome and neurodermatitis. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and aminoacyl-tRNA ligase activity. An important paralog of this gene is TARS2.

Gene Wiki entry for TARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARS Gene

Genomics for TARS Gene

Regulatory Elements for TARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TARS Gene

Chromosome:
5
Start:
33,440,696 bp from pter
End:
33,469,539 bp from pter
Size:
28,844 bases
Orientation:
Plus strand

Genomic View for TARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARS Gene

Proteins for TARS Gene

  • Protein details for TARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26639-SYTC_HUMAN
    Recommended name:
    Threonine--tRNA ligase, cytoplasmic
    Protein Accession:
    P26639
    Secondary Accessions:
    • A8K8I1
    • B4DEG8
    • Q96FP5
    • Q9BWA6

    Protein attributes for TARS Gene

    Size:
    723 amino acids
    Molecular mass:
    83435 Da
    Quaternary structure:
    • Homodimer
    SequenceCaution:
    • Sequence=AAB04939.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TARS Gene

    Alternative splice isoforms for TARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARS Gene

Proteomics data for TARS Gene at MOPED

Post-translational modifications for TARS Gene

  • ISGylated.
  • Ubiquitination at Lys 5, Lys 65, Lys 222, Lys 223, Lys 279, Lys 288, Lys 504, Lys 549, Lys 611, Lys 636, Lys 645, Lys 660, Lys 681, Lys 712, and Lys 717
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for TARS Gene

Gene Families for TARS Gene

Graphical View of Domain Structure for InterPro Entry

P26639

UniProtKB/Swiss-Prot:

SYTC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARS: view

Function for TARS Gene

Molecular function for TARS Gene

GENATLAS Biochemistry:
threonyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

Enzyme Numbers (IUBMB) for TARS Gene

Gene Ontology (GO) - Molecular Function for TARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004829 threonine-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TARS: view

Phenotypes for TARS Gene

genes like me logo Genes that share phenotypes with TARS: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TARS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TARS Gene

Localization for TARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARS Gene COMPARTMENTS Subcellular localization image for TARS gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 4
mitochondrion 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for TARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 2033077
GO:0005829 cytosol TAS --
GO:0015629 actin cytoskeleton IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with TARS: view

Pathways & Interactions for TARS Gene

genes like me logo Genes that share pathways with TARS: view

Pathways by source for TARS Gene

1 KEGG pathway for TARS Gene

Gene Ontology (GO) - Biological Process for TARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 2033077
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006435 threonyl-tRNA aminoacylation NAS 2033077
GO:0010467 gene expression TAS --
GO:0043039 tRNA aminoacylation --
genes like me logo Genes that share ontologies with TARS: view

No data available for SIGNOR curated interactions for TARS Gene

Drugs & Compounds for TARS Gene

(7) Drugs for TARS Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Threonine Approved Nutra Target 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Zinc Approved Pharma 1404
Diphosphate Experimental Pharma 0

(4) Additional Compounds for TARS Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Anticodon
tRNA
tRNA(Thr)
genes like me logo Genes that share compounds with TARS: view

Transcripts for TARS Gene

Unigene Clusters for TARS Gene

Threonyl-tRNA synthetase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TARS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TARS Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - - -
SP8: - - - - - - - - - - - - -
SP9: - - - -
SP10: - -

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TARS Gene

GeneLoc Exon Structure for
TARS
ECgene alternative splicing isoforms for
TARS

Expression for TARS Gene

mRNA expression in normal human tissues for TARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TARS Gene

This gene is overexpressed in Lymph node (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARS Gene



SOURCE GeneReport for Unigene cluster for TARS Gene Hs.481860

genes like me logo Genes that share expression patterns with TARS: view

Protein tissue co-expression partners for TARS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TARS Gene

Orthologs for TARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TARS 35
  • 90.96 (n)
  • 95.71 (a)
TARS 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARS 35
  • 91.7 (n)
  • 95.44 (a)
TARS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tars 35
  • 86.98 (n)
  • 95.01 (a)
Tars 16
Tars 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TARS 35
  • 99.69 (n)
  • 99.6 (a)
TARS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tars 35
  • 87.48 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia TARS 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TARS 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TARS 35
  • 79.51 (n)
  • 89.73 (a)
TARS 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1862 35
tars 35
  • 77.37 (n)
  • 90.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9104 35
zebrafish
(Danio rerio)
Actinopterygii tars 35
  • 76.35 (n)
  • 87.45 (a)
wufb07c05 35
tars 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2257 35
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 37
  • 73 (a)
Aats-thr 35
  • 66.92 (n)
  • 75.22 (a)
Aats-thr 36
  • 69 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008929 35
  • 65.17 (n)
  • 74.33 (a)
worm
(Caenorhabditis elegans)
Secernentea trs-1 37
  • 63 (a)
tars-1 35
  • 61.55 (n)
  • 64.21 (a)
tars-1 36
  • 59 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL039W 35
  • 58.14 (n)
  • 58.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05918g 35
  • 58.87 (n)
  • 57.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 35
  • 59.08 (n)
  • 58.68 (a)
THS1 36
  • 53 (a)
OneToMany
THS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26830 35
  • 58.18 (n)
  • 57.75 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.595 35
barley
(Hordeum vulgare)
Liliopsida Hv.6106 35
rice
(Oryza sativa)
Liliopsida Os.19842 35
Os08g0295300 35
  • 58.6 (n)
  • 58.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10053 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02380 35
  • 56.85 (n)
  • 56.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs1 35
  • 57.32 (n)
  • 59.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
ManyToMany
Species with no ortholog for TARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TARS Gene

ENSEMBL:
Gene Tree for TARS (if available)
TreeFam:
Gene Tree for TARS (if available)

Paralogs for TARS Gene

Paralogs for TARS Gene

genes like me logo Genes that share paralogs with TARS: view

Variants for TARS Gene

Sequence variations from dbSNP and Humsavar for TARS Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_034533 -

Structural Variations from Database of Genomic Variants (DGV) for TARS Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv471010 CNV Gain 18288195
dgv699n27 CNV Gain 19166990

Variation tolerance for TARS Gene

Residual Variation Intolerance Score: 91.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TARS Gene

HapMap Linkage Disequilibrium report
TARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARS Gene

Disorders for TARS Gene

MalaCards: The human disease database

(5) MalaCards diseases for TARS Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
antisynthetase syndrome
  • as syndrome
neurodermatitis
follicular mucinosis
  • alopecia mucinosa
dermatomyositis
  • polymyositis with skin involvement
myositis
  • inflammatory disorder of muscle
- elite association
Search TARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for TARS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TARS
genes like me logo Genes that share disorders with TARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TARS Gene

Publications for TARS Gene

  1. Binding and enantiomeric selectivity of threonyl-tRNA synthetase. (PMID: 19292486) Malde A.K. … Mark A.E. (J. Am. Chem. Soc. 2009) 23 67
  2. The structure of alanyl-tRNA synthetase with editing domain. (PMID: 19549823) Sokabe M. … Tanaka I. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  3. Intraphylum diversity and complex evolution of cyanobacterial aminoacyl-tRNA synthetases. (PMID: 18775898) Luque I. … Ochoa de Alda J.A. (Mol. Biol. Evol. 2008) 23 67
  4. N-terminal domains of native multidomain proteins have the potential to assist de novo folding of their downstream domains in vivo by acting as solubility enhancers. (PMID: 17384228) Kim C.W. … Seong B.L. (Protein Sci. 2007) 23 67
  5. Mechanism of tRNA-dependent editing in translational quality control. (PMID: 17185419) Ling J. … Ibba M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 23 67

Products for TARS Gene

Sources for TARS Gene

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