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Aliases for TARS Gene

Aliases for TARS Gene

  • Threonyl-TRNA Synthetase 2 3 4 5
  • EC 6.1.1.3 4 63
  • ThrRS 3 4
  • Threonyl-TRNA Synthetase, Cytoplasmic 3
  • Threonine TRNA Ligase 1, Cytoplasmic 3
  • Threonine TRNA Ligase 1 2
  • Cytoplasmic 2

External Ids for TARS Gene

Previous GeneCards Identifiers for TARS Gene

  • GC05U990056
  • GC05P033887
  • GC05P033440
  • GC05P033486

Summaries for TARS Gene

Entrez Gene Summary for TARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]

GeneCards Summary for TARS Gene

TARS (Threonyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with TARS include Myositis and Dermatomyositis. Among its related pathways are tRNA Aminoacylation and Gene Expression. GO annotations related to this gene include protein homodimerization activity and aminoacyl-tRNA ligase activity. An important paralog of this gene is TARS2.

Gene Wiki entry for TARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARS Gene

Genomics for TARS Gene

Regulatory Elements for TARS Gene

Enhancers for TARS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TARS on UCSC Golden Path with GeneCards custom track

Promoters for TARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TARS on UCSC Golden Path with GeneCards custom track

Genomic Location for TARS Gene

Chromosome:
5
Start:
33,440,696 bp from pter
End:
33,469,539 bp from pter
Size:
28,844 bases
Orientation:
Plus strand

Genomic View for TARS Gene

Genes around TARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARS Gene

Proteins for TARS Gene

  • Protein details for TARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26639-SYTC_HUMAN
    Recommended name:
    Threonine--tRNA ligase, cytoplasmic
    Protein Accession:
    P26639
    Secondary Accessions:
    • A8K8I1
    • B4DEG8
    • Q96FP5
    • Q9BWA6

    Protein attributes for TARS Gene

    Size:
    723 amino acids
    Molecular mass:
    83435 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB04939.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TARS Gene

    Alternative splice isoforms for TARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARS Gene

Proteomics data for TARS Gene at MOPED

Post-translational modifications for TARS Gene

  • ISGylated.
  • Ubiquitination at Lys 5, Lys 65, Lys 222, Lys 223, Lys 279, Lys 288, Lys 504, Lys 549, Lys 611, Lys 636, Lys 645, Lys 660, Lys 681, Lys 712, and Lys 717
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for TARS Gene

Gene Families for TARS Gene

Graphical View of Domain Structure for InterPro Entry

P26639

UniProtKB/Swiss-Prot:

SYTC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARS: view

Function for TARS Gene

Molecular function for TARS Gene

GENATLAS Biochemistry:
threonyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Enzyme Numbers (IUBMB) for TARS Gene

Gene Ontology (GO) - Molecular Function for TARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds IEA --
GO:0042803 protein homodimerization activity NAS 2033077
genes like me logo Genes that share ontologies with TARS: view
genes like me logo Genes that share phenotypes with TARS: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TARS Gene

Localization for TARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARS Gene COMPARTMENTS Subcellular localization image for TARS gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 2
nucleus 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for TARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,NAS 2033077
genes like me logo Genes that share ontologies with TARS: view

Pathways & Interactions for TARS Gene

genes like me logo Genes that share pathways with TARS: view

Pathways by source for TARS Gene

1 KEGG pathway for TARS Gene

Gene Ontology (GO) - Biological Process for TARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006435 threonyl-tRNA aminoacylation IEA,NAS 2033077
genes like me logo Genes that share ontologies with TARS: view

No data available for SIGNOR curated interactions for TARS Gene

Drugs & Compounds for TARS Gene

(7) Drugs for TARS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Threonine Approved Nutra Target 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(4) Additional Compounds for TARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TARS: view

Transcripts for TARS Gene

Unigene Clusters for TARS Gene

Threonyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TARS Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - - -
SP8: - - - - - - - - - - - - -
SP9: - - - -
SP10: - -

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TARS Gene

GeneLoc Exon Structure for
TARS
ECgene alternative splicing isoforms for
TARS

Expression for TARS Gene

mRNA expression in normal human tissues for TARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TARS Gene

This gene is overexpressed in Lymph node (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARS Gene



SOURCE GeneReport for Unigene cluster for TARS Gene Hs.481860

genes like me logo Genes that share expression patterns with TARS: view

Protein tissue co-expression partners for TARS Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TARS Gene

Orthologs for TARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TARS 35
  • 90.96 (n)
  • 95.71 (a)
TARS 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARS 35
  • 91.7 (n)
  • 95.44 (a)
TARS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tars 35
  • 86.98 (n)
  • 95.01 (a)
Tars 16
Tars 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TARS 35
  • 99.69 (n)
  • 99.6 (a)
TARS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tars 35
  • 87.48 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia TARS 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TARS 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TARS 35
  • 79.51 (n)
  • 89.73 (a)
TARS 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1862 35
tars 35
  • 77.37 (n)
  • 90.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9104 35
zebrafish
(Danio rerio)
Actinopterygii tars 35
  • 76.35 (n)
  • 87.45 (a)
wufb07c05 35
tars 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2257 35
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 37
  • 73 (a)
Aats-thr 35
  • 66.92 (n)
  • 75.22 (a)
Aats-thr 36
  • 69 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008929 35
  • 65.17 (n)
  • 74.33 (a)
worm
(Caenorhabditis elegans)
Secernentea trs-1 37
  • 63 (a)
tars-1 35
  • 61.55 (n)
  • 64.21 (a)
tars-1 36
  • 59 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL039W 35
  • 58.14 (n)
  • 58.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05918g 35
  • 58.87 (n)
  • 57.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 35
  • 59.08 (n)
  • 58.68 (a)
THS1 36
  • 53 (a)
OneToMany
THS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26830 35
  • 58.18 (n)
  • 57.75 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.595 35
barley
(Hordeum vulgare)
Liliopsida Hv.6106 35
rice
(Oryza sativa)
Liliopsida Os.19842 35
Os08g0295300 35
  • 58.6 (n)
  • 58.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10053 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02380 35
  • 56.85 (n)
  • 56.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs1 35
  • 57.32 (n)
  • 59.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
ManyToMany
Species with no ortholog for TARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TARS Gene

ENSEMBL:
Gene Tree for TARS (if available)
TreeFam:
Gene Tree for TARS (if available)

Paralogs for TARS Gene

Paralogs for TARS Gene

genes like me logo Genes that share paralogs with TARS: view

Variants for TARS Gene

Sequence variations from dbSNP and Humsavar for TARS Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34334786 - 33,445,328(+) GATTG(A/G)TGCTG nc-transcript-variant, reference, missense
rs7261 -- 33,467,824(-) TATTC(A/G)GACTT nc-transcript-variant, utr-variant-3-prime
rs893551 -- 33,457,545(-) TAGTT(C/T)GTACA intron-variant
rs2642668 -- 33,449,287(+) TTATC(A/C)AAATA intron-variant
rs2642669 -- 33,466,818(+) AGATC(A/C)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TARS Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv471010 CNV Gain 18288195
dgv699n27 CNV Gain 19166990

Variation tolerance for TARS Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TARS Gene

Disorders for TARS Gene

MalaCards: The human disease database

(5) MalaCards diseases for TARS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myositis
  • inflammatory disorder of muscle
dermatomyositis
  • amyopathic dermatomyositis
antisynthetase syndrome
  • anti-jo1 syndrome
follicular mucinosis
  • alopecia mucinosa
neurodermatitis
- elite association - COSMIC cancer census association via MalaCards
Search TARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for TARS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TARS
genes like me logo Genes that share disorders with TARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TARS Gene

Publications for TARS Gene

  1. Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes. (PMID: 2033077) Cruzen M.E. … Arfin S.M. (J. Biol. Chem. 1991) 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. (PMID: 15507440) Ruan B. … SAPll D. (J. Biol. Chem. 2005) 25 26
  5. Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase. (PMID: 12875846) Torres-Larios A. … Moras D. (J. Mol. Biol. 2003) 25 26

Products for TARS Gene

Sources for TARS Gene

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