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TARP Gene

protein-coding   GIFtS: 29

GC07M038265
TCR gamma alternate reading frame protein
symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CD3G 2
TARPS 5
TCRG 2
TCRGC1 2
TCRGC2 2
Descriptions
T cell receptor gamma alternate reading frame protein 2
T cell receptor gamma chain 2
T-cell receptor gamma-chain constant region 2
TCR gamma alternate reading frame protein 2
External Ids
Entrez Gene: 4453472
UniProtKB: Q0VGM34
Search outside databases for aliases for TARP gene

Previous GC identifers: GC07U901521 GC07M038055

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TARP:
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The
resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@
transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@
locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The
transcript represented by this RefSeq has two open reading frames (ORFs) that encode different
proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to
TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein.
[provided by RefSeq]

Gene Wiki entry for TARP
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TARP gene  

Entrez Gene cytogenetic band: 7p15-p14   

TARP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M038265:     (about GC identifiers)

Start:
38,265,769 bp from pter
End:
38,279,773 bp from pter
Size:
14,005 bases
Orientation:
minus strand
TARP has overlapping exons with:
TRG@

1 alternative location:
Chr7-,CRA_TCAG 38,336,925-38,350,939     
RefSeq DNA sequence:
NC_000007.12  NT_007819.16  NT_079592.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/TrEMBL: Q0VGM3 (See protein sequence)
Recommended Name: TARP protein  
Size: 111 amino acids; 12847 Da

REFSEQ proteins (2 alternative transcripts): 
NP_001003799.1  NP_001003806.1  

Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for TARP: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for TARP

Assays for TARP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR013783 Ig-like_fold


   GeneDecks  TARP for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q0VGM3

ProtoNet protein and cluster: Q0VGM3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TARP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001003799

              Applied Biosystems Silencer® siRNAs for TARP

              Sigma-Aldrich siRNA for TARP  
                     Sigma-Aldrich shRNA for TARP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001003799
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001003799
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001003799 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001003806

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TARP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TARP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001003799

              Sigma-Aldrich siRNA for TARP  
                     Sigma-Aldrich shRNA for TARP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001003799  NM_001003806  

REFSEQ mRNAs for TARP gene (2 alternative transcripts): 

NM_001003799.1   NM_001003806.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001003799  NM_001003806  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001003799
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001003799
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001003799 

Additional cDNA sequence: 

AF085845.1 AF151103.1 AF512447.1 AF512448.1 AF512449.1 AF512450.1 AF512451.1 AF512452.1 
AF512453.1 AF512454.1 AF512455.1 AF512456.1 AF512457.1 AJ583012.1 AJ583014.1 AK056843.1 
AK291611.1 AK301059.1 BC017861.1 BC027954.1 BC030554.1 BC035592.1 BC039116.1 BC062761.1 
BC071739.1 BC072387.1 BC072396.1 BC105589.1 CR605178.1 EU395807.1 M13231.1 M16768.1 
M16804.1 M17323.1 M17324.1 M17325.1 M27331.1 M27332.1 M27333.1 M27334.1 
M27335.1 M27336.1 M27337.1 M27339.1 M27340.1 M27341.1 M27342.1 M27343.1 
M27344.1 M27345.1 M30894.1 M89826.1 M89828.1 M89838.1 S60175.1 S60779.1 
S60780.1 S73842.1 X06774.1 X06775.1 X06776.1 X15019.1 X72500.1 X74774.1 
X74775.1 Y00482.1 Y00790.1 Z11169.1 Z11170.1 Z11171.1 Z11172.1 Z11173.1 
Z11174.1 Z11175.1 Z11176.1 Z11177.1 Z11178.1 Z11179.1 Z11180.1 Z11181.1 
Z11182.1 Z11183.1 Z11184.1 Z11185.1 Z11186.1 Z11187.1 Z11188.1 Z11189.1 
Z11190.1 Z11191.1 Z11192.1 Z11193.1 Z11194.1 Z11195.1 Z11196.1 Z11197.1 
Z11198.1 Z11199.1 Z11200.1 Z11201.1 Z11202.1 Z11203.1 Z11204.1 Z11205.1 
Z11206.1 Z11207.1 Z11208.1 Z11209.1 Z11210.1 Z11211.1 Z11212.1 Z11213.1 
Z11214.1 Z11215.1 Z11216.1 Z11217.1 Z11218.1 Z11219.1 Z11220.1 Z11221.1 
Z11222.1 Z11223.1 Z11224.1 Z11225.1 Z11226.1 Z11227.1 Z11228.1 Z11229.1 
Z11230.1 Z11231.1 Z11232.1 Z11233.1 Z11234.1 Z11235.1 Z11236.1 Z11237.1 
Z11238.1 Z11239.1 Z11240.1 Z11241.1 Z11242.1 Z11243.1 Z11244.1 Z11245.1 
Z11246.1 Z11247.1 Z11248.1 Z11249.1 Z11250.1 Z11251.1 Z11252.1 Z11253.1 
Z11254.1 Z11255.1 Z11256.1 Z11257.1 Z11258.1 Z11259.1 Z11260.1 Z11261.1 
Z11262.1 Z11263.1 Z11264.1 Z11265.1 Z11266.1 Z11267.1 Z11268.1 Z11269.1 
Z11270.1 Z11271.1 Z11272.1 Z11273.1 Z11274.1 Z11275.1 Z11276.1 Z11277.1 
Z11278.1 Z11279.1 Z11280.1 Z11281.1 Z11282.1 Z11283.1 Z11284.1 Z11285.1 
Z11286.1 Z11287.1 Z11288.1 Z11289.1 Z11290.1 Z11291.1 Z11292.1 Z11293.1 
Z11294.1 Z11295.1 Z11296.1 Z11297.1 Z11298.1 Z11299.1 Z11300.1 Z11301.1 
Z11302.1 Z11303.1 Z11304.1 Z11305.1 Z11306.1 Z11307.1 Z11308.1 Z11309.1 
Z11310.1 Z11311.1 Z11312.1 Z11313.1 Z11314.1 Z11315.1 Z11316.1 Z11317.1 
Z11318.1 Z11319.1 Z11320.1 Z11321.1 Z11322.1 Z11323.1 Z11324.1 Z11325.1 
Z11326.1 Z11327.1 Z11328.1 Z11329.1 Z11330.1 Z11331.1 Z11332.1 Z11333.1 
Z11334.1 Z11335.1 Z11336.1 Z11337.1 Z11338.1 Z11339.1 Z11340.1 Z11341.1 
Z11342.1 Z11343.1 Z11344.1 Z11345.1 Z11346.1 Z11347.1 Z11348.1 Z11349.1 
Z11350.1 Z11351.1 Z11352.1 Z11353.1 Z11354.1 Z11355.1 Z11356.1 Z11357.1 
Z11358.1 Z11359.1 Z11360.1 Z11361.1 Z11362.1 Z11363.1 Z11364.1 Z11365.1 
Z11366.1 Z11367.1 Z11368.1 Z11369.1 Z11370.1 Z11371.1 Z11372.1 Z11373.1 
Z11374.1 Z11375.1 Z11376.1 Z11377.1 Z11378.1 Z11379.1 Z11380.1 Z11381.1 
Z11382.1 Z11383.1 Z11384.1 Z11385.1 Z11386.1 Z11387.1 Z11388.1 Z11389.1 
Z11390.1 Z11391.1 Z11392.1 Z11393.1 Z11394.1 Z11395.1 Z11396.1 Z11397.1 
Z11398.1 Z11399.1 Z11400.1 Z11401.1 Z11402.1 Z11403.1 Z11404.1 Z11405.1 
Z11406.1 Z11407.1 Z11408.1 Z11409.1 Z11410.1 Z22679.1 

24/28 DOTS entries (see all 28 ):

DT.100777063  DT.40271042  DT.121071534  DT.100777062  DT.91910769  DT.95158208  DT.75117417  DT.95159668 
DT.100692280  DT.100777067  DT.429710  DT.86846831  DT.445989  DT.92427347  DT.437577  DT.95363650 
DT.121071536  DT.121071573  DT.70105015  DT.121071542  DT.70103538  DT.91985524  DT.95128321  DT.121071529 

highest scoring ESTs for TARP:

AA076849 AA492249 AA501934 AA513751 AA532957 AA533199 AA551316 AA570532 AF085845 AI202248 

Unigene Cluster for TARP:

TCR gamma alternate reading frame protein
Hs.534032  [show with all ESTs]
Unigene Representative Sequence: BC030554


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TARP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TARP

1 / 2 / 3

11 probe-sets matching TARP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
41468_at2, 3 U95-A 5 1.00 0.29 1.00 1.00 M30894 0.60 0.35 0.49 1

215806_x_at2, 3 U133-A 4 1.00 0.30 -- -- M13231 0.40 0.35 0.38 1

216920_s_at2, 3 U133-A 4 1.00 0.30 -- -- M27331 0.20 0.33 0.27 2

209813_x_at2, 3 U133-A 4 1.00 0.30 -- -- M16768 0.40 0.38 0.39 1

211144_x_at2, 3 U133-A 4 1.00 0.30 -- -- M30894 0.60 0.35 0.49 1

217381_s_at2 U133-A 3 0.82 0.29 -- -- -- -- -- -- --

215806_x_at2 U133Plus2 4 1.00 0.30 -- -- -- -- -- -- --

216920_s_at2 U133Plus2 4 1.00 0.30 -- -- -- -- -- -- --

209813_x_at2 U133Plus2 4 1.00 0.30 -- -- -- -- -- -- --

211144_x_at2 U133Plus2 4 1.00 0.30 -- -- -- -- -- -- --

217381_s_at2 U133Plus2 3 0.82 0.29 -- -- -- -- -- -- --
GeneDecks  TARP for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.534032
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TARP gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6093601   -- similar to T-cell receptor gamma chain C region DFL12 71.77(n)
55.86(a)
609360  XM_846603.1  XP_851696.1 
chimpanzee
(Pan troglodytes)
LOC7477361   -- similar to T cell recepter Ti gamma 99.7(n)
99.1(a)
747736  XM_001170560.1  XP_001170560.1 
cow
(Bos taurus)
TARP1   -- TCR gamma alternate reading frame protein 73.65(n)
60.95(a)
781378  XM_001249422.1  XP_001249423.1 
mouse
(Mus musculus)
LOC6240711   -- similar to T-cell receptor gamma chain C region C7.5 77.27(n)
68.18(a)
624071  NM_001081305.1  NP_001074774.1 
chicken
(Gallus gallus)
LOC7763091   -- similar to T-cell receptor gamma V2.6a   -- 776309  XM_001235439.1  XP_001235440.1 
About this table        Species with no ortholog for TARP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/111 NCBI SNPs in TARP are shown (see all 111 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs77777571,2
C,F,H38271744(+) TTGTTT/GCAGCA 2 Q/K mis1 ut514Minor allele frequency- G:0.01EU EA WA 420
--
rs42622431,2
F,H38265725(+) TGGATG/ATTCAA 2 -- ng512Minor allele frequency- A:0.15EU WA 230
rs27369741,2
C,H38281353(-) ATTAGT/CAAAgt 2 -- ng314Minor allele frequency- C:0.00EU EA WA 414
--
rs20070811,2
F,H38271608(+) GTGTCG/ATTAGT 2 N/N syn1 ut315Minor allele frequency- A:0.11MN EU EA WA 598
--
rs10537601,2
C,F38271568(-) CAGAAG/AAGTCA 2 E/K mis1 ut311Minor allele frequency- A:0.39MN 184
--
rs174213611,2
F38266314(-) TTACAT/CGTACC 2 T/M mis1 ut311Minor allele frequency- C:0.28MN 184
--
rs21093651,2
A,C,F,H38269645(+) ATGGTT/CGTTTT 2 -- int111Minor allele frequency- C:0.44EU EA WA NA 980
--
rs102628301,2
A,C,F,H38277623(+) atatcG/Aacatg 2 -- int18Minor allele frequency- A:0.10EU EA WA 834
--
rs23925421,2
A,C,F38268266(+) AATGAT/ACAGGA 2 -- int15Minor allele frequency- A:0.42EA NA 1712
--
rs20750111,2
C,F,H38275874(+) AACATC/TGCTAC 2 -- int18Minor allele frequency- T:0.11EA NA EU WA 2018
About this table

HapMap Linkage Disequilibrium images for TARP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 311900

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/12 PubMed articles for TARP gene (see all 12 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 445347 euGenes: HUgn445347
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TARP:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TARP-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for TARP Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for TARP Browse small molecules at Sigma-Aldrich
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