TARP Gene
protein-coding GIFtS: 31
GCID: GC07M038299
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TARP
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Aliases
for TARP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
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|
| Aliases |
|---|
| CD3G2 | | TCRG2 | | TCRGC12 | | TCRGC22 | | T-Cell Receptor Gamma-Chain Constant Region2 | | TCR Gamma Alternate Reading Frame Protein2 |
Export aliases for TARP gene to outside databasesPrevious GC identifers: GC07U901521 GC07M038055 GC07M038265 GC07M038183 GC07M038308 |
Summaries
for TARP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TARP:
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resultingtranscript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoidtissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is representedby the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) thatencode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@proteins. The upstream ORF uses a different reading frame and encodes a novel protein. (provided by RefSeq, Jul 2008)
Gene Wiki entry for TARP
|
Genomic Views
for TARP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TARP gene promoter:
STAT1 STAT1beta Nkx2-5 CUTL1 STAT1alpha MZF-1 POU2F1 Nkx6-1 POU2F1a STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TARP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TARP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p15-p14 TARP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M038299: view genomic region
(about GC identifiers)
Start:
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38,299,244 bp from pter |
End:
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38,313,248 bp from pter |
Size:
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14,005 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 38,336,925-38,350,939 |
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Proteins
for TARP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/TrEMBL: Q0VGM3 (See
protein sequence)Recommended Name: TARP protein Size: 111 amino acids; 12847 DaTARP Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001003799.1 NP_001003806.1
Human Recombinant Protein Products:
TARP Antibody Products:
Assay Products for TARP: |
Protein
Domains /
Families
for TARP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TARP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q0VGM3ProtoNet protein and cluster: Q0VGM3 |
Function
for TARP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TARP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARP |
1 GenomeRNAi human phenotype for TARP:
|
Pathways & Interactions
for TARP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TARP
|
Drugs & Compounds
for TARP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TARP
Search CenterWatch for drugs/clinical trials and news about TARP
|
Transcripts
for TARP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TARP gene (2 alternative transcripts): NM_001003799.1 NM_001003806.1 Unigene Clusters for TARP: TCR gamma alternate reading frame protein Hs.534032 [show with all ESTs], Hs.731375 [show with all ESTs]Unigene Representative Sequences: BC030554, BC027954
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TARP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TARP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARP |
Additional cDNA sequence: AK291611.1 AK301059.1 BC027954.1 BC035592.1 BC039116.1 BC071739.1 M13231.1 M16804.1 M17323.1 M27333.1 M27336.1 M27337.1 M27338.1 M27340.1 M27341.1 M27342.1 M27343.1 M27344.1 M27345.1 M30894.1 M89838.1 S60175.1 S73842.1 X06774.1 X06775.1 X06776.1 X15019.1 Y00482.1 Y00790.1 Z11172.1 Z11262.1 Z11263.1 Z11276.1 Z22679.1 Z22686.1 Z22687.1 24/28 DOTS entries (see all 28): DT.100777063 DT.40271042 DT.121071534 DT.100777062 DT.91910769 DT.95158208 DT.95159668 DT.100777067 DT.429710 DT.86846831 DT.92427347 DT.100692280 DT.445989 DT.437577 DT.95363650 DT.121071536 DT.121071573 DT.70105015 DT.121071542 DT.70103538 DT.91985524 DT.95128321 DT.121071468 DT.121071529
GeneLoc Exon Structure
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Expression
for TARP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TARP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCCACAG
About this image
Genevestigator expression for TARP
SOURCE GeneReport for Unigene clusters: Hs.534032 Hs.731375
SABiosciences Custom PCR Arrays for TARP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TARP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TARP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TARP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TARP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARP |
Orthologs
for TARP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for TARP gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TARP1 |
TCR gamma alternate reading frame protein |
45.28(n)
30.19(a) |
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776306 XM_001235432.2 XP_001235433.2 |
Species with no ortholog for TARP |
Paralogs
for TARP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TARP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for TARP
13 CNVs: 62641 34443 31340 23285 59409 3676 4530 64800 99927 2691 7627 9054 44309 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TARP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TARP for disorders About GeneDecksing
OMIM gene information: 609642
OMIM disorders: --
7  diseases for TARP: About MalaCardslymphogranuloma venereum lymphoblastic leukemia t-cell leukemia leukemia
prostate cancer breast cancer prostatitis
2 diseases from the University of Copenhagen DISEASES database for TARP:Leukemia Lymphoma Human Genome Epidemiology (HuGE) Navigator: TARP (3 documents)
Export disorders for TARP gene to outside databases
|
Publications
for TARP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TARP gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TARP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells . (PubMed id 23019373)1 Hillerdal V....Essand M. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genetic variation in hyaluronan metabolism loci is as sociated with plasma plasminogen activator inhibitor-1 concentration. (PubMed id 20558613)1 Lanktree M.B.... . (2010)
- Diagnostic and prognostic value of T-cell receptor ga mma alternative reading frame protein (TARP) expression in prostate cancer. (PubMed id 20376779)1 Fritzsche F.R....Kristiansen G. (2010)
- Antibody responses to galectin-8, TARP and TRAP1 in p rostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy. (PubMed id 20499060)1 Nguyen M.C....Harding T.C. (2010)
- Prolonged antigen survival and cytosolic export in cr oss-presenting human gammadelta T cells. (PubMed id 20413723)1 Meuter S....Moser B. (2010)
- Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy. (PubMed id 18321859)1 Chen H....He W. (2008)
- The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. (PubMed id 15150260)1 Maeda H....Pastan I. (2004)
- Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PubMed id 12865322)1 Cheng W.S....Essand M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TARP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TARP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TARP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TARP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TARP gene:
Search GeneIP for patents involving TARP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TARP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TARP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TARP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TARP | | | OriGene Protein Over-expression Lysate for TARP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TARP | | OriGene 3'-UTR Clone for TARP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARP |
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