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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TARP Gene

protein-coding   GIFtS: 32
GCID: GC07M038299

TCR Gamma Alternate Reading Frame Protein


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD3G2
TCRG2
TCRGC12
TCRGC22
T-Cell Receptor Gamma-Chain Constant Region2
TCR Gamma Alternate Reading Frame Protein2

External Ids:    Entrez Gene: 4453472   OMIM: 6096425   UniProtKB: Q0VGM34   

Export aliases for TARP gene to outside databases

Previous GC identifers: GC07U901521 GC07M038055 GC07M038265 GC07M038183 GC07M038308


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TARP Gene:
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting
transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid
tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is
represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading
frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein
product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TARP Gene: 
TARP is a protein-coding gene. Diseases associated with TARP include lymphogranuloma venereum, and t-cell leukemia.

Gene Wiki entry for TARP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TARP gene promoter:
         STAT1   STAT1beta   Nkx2-5   CUTL1   STAT1alpha   MZF-1   POU2F1   Nkx6-1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 15): TARP promoter sequence
   Search SABiosciences Chromatin IP Primers for TARP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TARP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p14   

TARP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M038299:  view genomic region     (about GC identifiers)

Start:
38,299,244 bp from pter      End:
38,313,248 bp from pter
Size:
14,005 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,336,925-38,350,939     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/TrEMBL: Q0VGM3 (See protein sequence)
Recommended Name: TARP protein  
Size: 111 amino acids; 12847 Da

TARP Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins (2 alternative transcripts): 
NP_001003799.1  NP_001003806.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q0VGM3

ProtoNet protein and cluster: Q0VGM3


TARP for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TARP:
 Decreased Wnt reporter activit 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TARP

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TARP

Search CenterWatch for drugs/clinical trials and news about TARP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TARP gene (2 alternative transcripts): 
NM_001003799.1  NM_001003806.1  

Unigene Clusters for TARP:

TCR gamma alternate reading frame protein
Hs.534032  [show with all ESTs], Hs.731375  [show with all ESTs]
Unigene Representative Sequences: BC030554, BC027954
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AK291611.1 AK301059.1 BC027954.1 BC035592.1 BC039116.1 BC071739.1 M13231.1 M16804.1 
M17323.1 M27333.1 M27336.1 M27337.1 M27338.1 M27339.1 M27340.1 M27341.1 
M27342.1 M27343.1 M27344.1 M27345.1 M30894.1 M89838.1 S60175.1 S73842.1 
X06774.1 X06775.1 X06776.1 X15019.1 Y00482.1 Y00790.1 Z11172.1 Z11237.1 
Z11260.1 Z11262.1 Z11263.1 Z11276.1 Z22679.1 Z22686.1 Z22687.1 

24/28 DOTS entries (see all 28):

DT.100777063  DT.40271042  DT.121071534  DT.100777062  DT.91910769  DT.95158208  DT.95159668  DT.100777067 
DT.429710  DT.86846831  DT.92427347  DT.100692280  DT.445989  DT.437577  DT.95363650  DT.121071536 
DT.121071573  DT.70105015  DT.121071542  DT.70103538  DT.91985524  DT.95128321  DT.121071468  DT.121071529 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TARP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTTCCACAG
TARP Expression
About this image


Genevestigator expression for TARP

SOURCE GeneReport for Unigene clusters: Hs.534032 Hs.731375
    SABiosciences Custom PCR Arrays for TARP
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TARP gene from 2/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
rat
(Rattus norvegicus)
Mammalia LOC6812901 T-cell receptor gamma chain C region 5/10-13-like 69.97(n)
60.36(a)
  681290  XM_002728486.1  XP_002728532.1 
chicken
(Gallus gallus)
Aves TARP1 TCR gamma alternate reading frame protein 45.28(n)
30.19(a)
  776306  XM_001235432.2  XP_001235433.2 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TARP gene
2 SIMAP similar genes for TARP using alignment to 1 protein entry:     Q0VGM3_HUMAN:
TRGC1    TRGC2

TARP for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/460 SNPs in TARP are shown (see all 460)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1410656181,2
C--38298763(+) GGAGA-/TTTATG 2 -- ds50010--------
rs770362621,2
C--38298853(+) TGTGCC/TGAACC 2 -- ds50010--------
rs1492078751,2
C--38298961(+) TCACAC/TGGTAC 2 -- ds50010--------
rs1131380651,2
C--38298962(+) CACACG/AGTACG 2 -- ds50011Minor allele frequency- A:0.50NA 2
rs1479228881,2
--38299016(+) CCGAAC/TGAATC 2 -- ds50010--------
rs1879742901,2
--38299102(+) AACCAC/TGATCT 2 -- ds50010--------
rs42622431,2
C,F,H--38299200(+) TGGATG/ATTCAA 2 -- ds50015Minor allele frequency- A:0.15NS NA WA 236
rs1930364901,2
--38299212(+) TTGATA/GTCATC 2 -- ds50010--------
rs1470971171,2
C--38299232(+) TACCAC/TGGACA 2 -- ds50010--------
rs715467021,2
C,F--38299242(+) AAAAGC/TCAACT 2 -- ds50011Minor allele frequency- T:0.50NA 2

HapMap Linkage Disequilibrium report for TARP (38299244 - 38313248 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/24 variations for TARP (see all 24):    About this table     
Variant IDTypeSubtypePubMed ID
esv2734278CNV Deletion23290073
esv1000823CNV Deletion20482838
esv2534366CNV Deletion19546169
esv2734277CNV Deletion23290073
esv2108072CNV Deletion18987734
esv2734276CNV Deletion23290073
nsv436906CNV Insertion17901297
nsv824074CNV Loss20364138
nsv887963CNV Loss21882294
esv29985CNV Loss17803354

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609642    OMIM disorders: --

7 diseases for TARP:    About MalaCards
lymphogranuloma venereum    t-cell leukemia    lymphoblastic leukemia    prostate cancer
prostatitis    leukemia    breast cancer

2 diseases from the University of Copenhagen DISEASES database for TARP:
Leukemia     Lymphoma

TARP for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: TARP (3 documents)

Export disorders for TARP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TARP gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TARP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells . (PubMed id 23019373)1 Hillerdal V....Essand M. (2012)
  2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  3. Genetic variation in hyaluronan metabolism loci is as sociated with plasma plasminogen activator inhibitor-1 concentration. (PubMed id 20558613)1 Lanktree M.B.... . (2010)
  4. Diagnostic and prognostic value of T-cell receptor ga mma alternative reading frame protein (TARP) expression in prostate cancer. (PubMed id 20376779)1 Fritzsche F.R....Kristiansen G. (2010)
  5. Antibody responses to galectin-8, TARP and TRAP1 in p rostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy. (PubMed id 20499060)1 Nguyen M.C....Harding T.C. (2010)
  6. Prolonged antigen survival and cytosolic export in cr oss-presenting human gammadelta T cells. (PubMed id 20413723)1 Meuter S....Moser B. (2010)
  7. Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy. (PubMed id 18321859)1 Chen H....He W. (2008)
  8. The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. (PubMed id 15150260)1 Maeda H....Pastan I. (2004)
  9. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PubMed id 12865322)1 Cheng W.S....Essand M. (2003)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 445347 euGenes: HUgn445347

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TARP gene:
Search GeneIP for patents involving TARP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for TARP
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 SwitchGear 3'UTR luciferase reporter plasmids for TARP
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARP
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TARP
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TARP
Customized:
 lentivirus for stable overexpression of TARP
 lentivirus expression plasmids for stable overexpression of TARP
 adenovirus for overexpression of TARP
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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