TARDBP Gene
protein-coding GIFtS: 60
GCID: GC01P011006
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|
TAR DNA binding protein
| |
Aliases
for TARDBP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAR DNA Binding Protein1 2 | | TDP-431 2 3 | | ALS101 2 5 | | TDP433 5 | | TAR DNA-Binding Protein 432 | | TAR DNA-Binding Protein-432 |
Export aliases for TARDBP gene to outside databasesPrevious GC identifers: GC01P011033 GC01P010916 GC01P010682 GC01P010782 GC01P010224 |
Summaries
for TARDBP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TARDBP:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces achromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivatorTat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. Theprotein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA andrepresses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similarpseudogene is present on chromosome 20. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148Function: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTRsplicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical ofcystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL)mRNA through a direct interaction with the 3' UTR
Gene Wiki entry for TARDBP
|
Genomic Views
for TARDBP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TARDBP gene promoter:
Pbx1a Tal-1 STAT5A IRF-1 E47 HEN1 Hand1 c-Myb LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TARDBP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TARDBP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22TARDBP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P011006: view genomic region
(about GC identifiers)
Start:
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11,072,414 bp from pter |
End:
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11,085,796 bp from pter |
Size:
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13,383 bases |
Orientation:
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plus strand |
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Proteins
for TARDBP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148 (See
protein sequence)Recommended Name: TAR DNA-binding protein 43 Size: 414 amino acids; 44740 Da
Subunit: Homodimer. Interacts with BRDT (By similarity). Binds specifically to pyrimidine-rich motifs of TAR DNA and tosingle stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of sixcontiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent
Subcellular location: Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateralsclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmicubiquitin-positive inclusion bodies
2 PDB 3D structures from  and Proteopedia  for TARDBP:1WF0 (3D)
2CQG (3D)
Secondary accessions: A4GUK4 A4GUK5 A4GUK6 B2R629 E2PU12 Q53H27 Q6FI92 Q96DJ0Alternative splicing: 3 isoforms: Q13148-1 Q13148-2 Q13148-3 Explore the universe of human proteins at neXtProt for TARDBP: NX_Q13148
Post-translational modifications:
Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU1
Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU1
Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALSand FTLDU1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13148
TARDBP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_031401.1
ENSEMBL proteins: ENSP00000465240 ENSP00000240185 ENSP00000466842 ENSP00000465080 ENSP00000313129 ENSP00000432132 ENSP00000465888 ENSP00000467020 ENSP00000404666
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TARDBP for ontologies About GeneDecksing
TARDBP Antibody Products:
Assay Products for TARDBP: |
Protein
Domains /
Families
for TARDBP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TARDBP for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13148ProtoNet protein and cluster: Q13148 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148Domain: The RRM domains can bind to both DNA and RNA (By similarity)Similarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for TARDBP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148Function: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTRsplicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical ofcystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL)mRNA through a direct interaction with the 3' UTR
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARDBP (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARDBP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TARDBP (NM_007375) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TARDBP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARDBP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARDBP |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
TARDBP for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TARDBP: Tardbptm1.1Ckjs Tardbptm1.2Pcw
8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Tardbp):
TARDBP for phenotypes About GeneDecksing
|
Pathways & Interactions
for TARDBP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Neuroscience | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for TARDBP
TARDBP for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TARDBP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/786 Interacting proteins for TARDBP (Q131481, 2, 3 ENSP000002401854) via UniProtKB, MINT, STRING, and/or I2D (see all 786)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
TARDBP for ontologies About GeneDecksing
|
Drugs & Compounds
for TARDBP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TARDBP for compounds About GeneDecksing
 Browse Tocris compounds for TARDBP
1 Novoseek chemical compound relationship for TARDBP gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| superoxide |
16.9 |
4 |
18396105 (1), 19104447 (1), 20232451 (1) |
Search CenterWatch for drugs/clinical trials and news about TARDBP / TADBP
|
Transcripts
for TARDBP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TARDBP gene: NM_007375.3 Unigene Cluster for TARDBP: TAR DNA binding protein Hs.300624 [show with all ESTs]Unigene Representative Sequence: NM_00737510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473118 ENST00000240185(uc001art.3 uc010oap.2) ENST00000476201
ENST00000472476 ENST00000315091 ENST00000473869 ENST00000477447 ENST00000496840
ENST00000480464 ENST00000439080
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARDBP (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARDBP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TARDBP (NM_007375) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TARDBP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARDBP |
Additional cDNA sequence: AF311304.1 AK222754.1 AK295920.1 AK299454.1 AK312416.1 AL050265.1 BC001487.2 BC059955.1 BC071657.1 BC095435.1 CR533534.1 EF434181.1 EF434182.1 EF434183.1 U23731.1 24/35 DOTS entries (see all 35): DT.419641 DT.100882432 DT.100882435 DT.100882440 DT.121392100 DT.451822 DT.100882442 DT.97860226 DT.100032539 DT.97856390 DT.100882434 DT.75151703 DT.91786971 DT.100882437 DT.91884354 DT.40107291 DT.410821 DT.100038829 DT.100882443 DT.121392045 DT.100882429 DT.121392089 DT.105463 DT.121392078 24/668 AceView cDNA sequences (see all 668): CD365721 AI924941 AW089116 BX951678 AA489215 AA864355 AI436335 AA704526 BF195778 BC001487 BQ446424 BU684769 AI203100 AA626812 BP360056 AU139698 AA524141 AW196174 CR611899 CK904731 AA535621 BM091399 BX422262 AI560398
GeneLoc Exon Structure
|
Expression
for TARDBP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TARDBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTGAGCTT
About this image
See TARDBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TARDBP
SOURCE GeneReport for Unigene cluster: Hs.300624
UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148Tissue specificity: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genitaltract and spleen
SABiosciences Custom PCR Arrays for TARDBP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TARDBP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TARDBP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TARDBP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TARDBP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARDBP |
Orthologs
for TARDBP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TARDBP gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TARDBP1 |
TAR DNA binding protein |
82.45(n)
95.17(a) |
|
419453 NM_001030878.1 NP_001026049.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
tardbp-prov2 |
TAR DNA binding protein |
80.44(n) |
|
BC044271.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb77f022 |
Danio rerio mRNA similar to TAR DNA binding protein more |
75.89(n) |
|
BC049348.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
TBPH1 , 3 |
RNA binding3
CG10327-PA1 |
56(a)
(best of 2)3
53.17(n)1
50.79(a)1 |
|
377811 NM_166628.21 NP_726373.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F44G4.43
tdp-11 |
RNA binding protein3
Protein TDP-11 |
38(a)3
50.12(n)1
43.88(a)1 |
|
II(8997742-8999439)3
1744361 NM_001026995.41 NP_001022166.11 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 3) |
RNA recognition motif containing protein, putative...RNA recognition motif containing protein, putative...(see all 3) |
16(a)13(a)(see all 3) |
1 ↔ many1 ↔ many(see all 3) |
7(1280379-1284075) 1(32302655-32305593) |
ENSEMBL Gene Tree for TARDBP (if available)
TreeFam Gene Tree for TARDBP (if available) |
Paralogs
for TARDBP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TARDBP gene
7 SIMAP similar genes for TARDBP using alignment to 10 protein entries: TADBP_HUMAN (see all proteins):SS18 NARF MSI2 HNRNPD SLIRP CIRBP
HNRNPA1
TARDBP for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for TARDBP (see all 6)
PGOHUM00000248612 PGOHUM00000247437 PGOHUM00000241150 PGOHUM00000243309 PGOHUM00000260408
|
Genomic Variants
for TARDBP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TARDBP (11072414 - 11085796 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TARDBP: --
Human Gene Mutation Database (HGMD): TARDBP
Locus Specific Mutation Databases (LSDB): TARDBP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TARDBP |
|
Disorders
/ Diseases
for TARDBP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TARDBP for disorders About GeneDecksing
OMIM gene information: 605078
OMIM disorders: 612069
UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148
Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:612069]. ALS is aneurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensoryabnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to bemultifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases
20/50  diseases for TARDBP (see all 50): About MalaCardsfrontotemporal lobar degeneration, tardbp-related frontotemporal lobar degeneration with ubiquitin-positive inclusions amyotrophic lateral sclerosis 10, with or without ftd amyotrophic lateral sclerosis
tardbp-related amyotrophic lateral sclerosis inclusion body myopathy amyotrophic lateral sclerosis type 10 lateral sclerosis
spinal muscular atrophy machado-joseph disease acquired immunodeficiency syndrome amyotrophic lateral sclerosis with frontotemporal dementia
frontotemporal dementia amyotrophic lateral sclerosis (als) immunodeficiency primary progressive aphasia
gaze palsy semantic dementia traumatic brain injury corticobasal degeneration
5 diseases from the University of Copenhagen DISEASES database for TARDBP:Frontotemporal dementia Amyotrophic lateral sclerosis Aphasia Progressive supranuclear palsy
Lateral sclerosis 10/13 Novoseek disease relationships for TARDBP gene (see all 13) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| frontotemporal dementia |
96.1 |
125 |
18989115 (3), 18087705 (2), 18535185 (2), 19618195 (2) (see all 77) |
| amyotrophic lateral sclerosis |
92.3 |
141 |
18989115 (4), 19760257 (2), 18396105 (2), 18802454 (2) (see all 76) |
| motor neuron disease |
85.1 |
18 |
18087705 (2), 18288693 (1), 19554515 (1), 17492294 (1) (see all 11) |
| inclusion body myopathy |
80.4 |
2 |
18796596 (2) |
| neurodegeneration |
75.6 |
28 |
18396105 (2), 17898224 (2), 18068872 (1), 18634762 (1) (see all 14) |
| neurodegenerative diseases |
75.2 |
35 |
19554515 (3), 18802454 (2), 18929508 (2), 18288693 (1) (see all 16) |
| picks disease |
72.2 |
3 |
18091558 (1), 18607609 (1), 19554515 (1) |
| dementia |
63.8 |
23 |
19112176 (1), 19760257 (1), 19458543 (1), 19411082 (1) (see all 10) |
| alzheimers disease |
55 |
17 |
18634762 (2), 18592255 (2), 18929508 (1), 19554515 (1) (see all 12) |
| neurofibrillary tangles |
45.4 |
1 |
18592255 (1) |
GeneTests: TARDBP
TARDBP-Related Amyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis
Human Genome Epidemiology (HuGE) Navigator: TARDBP (24 documents)
Export disorders for TARDBP gene to outside databases
|
Publications
for TARDBP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TARDBP gene, integrated from 9 sources (see all 367):
(articles sorted by number of sources associating them with TARDBP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. (PubMed id 7745706)1, 2, 3, 9 Ou S.-H.I.... Gaynor R.B. (1995)
- TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. (PubMed id 18396105)1, 2, 9 Van Deerlin V.M....Yu C.E. (2008)
- High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis. (PubMed id 19224587)1, 2, 9 Corrado L.... D'Alfonso S. (2009)
- TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration. (PubMed id 19350673)1, 2, 9 Benajiba L....Brice A. (2009)
- TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. (PubMed id 18309045)1, 2, 9 Sreedharan J....Shaw C.E. (2008)
- TDP-43 mutation in familial amyotrophic lateral sclerosis. (PubMed id 18438952)1, 2, 9 Yokoseki A.... Onodera O. (2008)
- TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. (PubMed id 17481916)1, 2, 9 Strong M.J....Shoesmith C. (2007)
- TDP-43 A315T mutation in familial motor neuron disease. (PubMed id 18288693)1, 2, 9 Gitcho M.A.... Cairns N.J. (2008)
- Novel TARDBP mutations in Nordic ALS patients. (PubMed id 22456481)1, 2 Chiang H.H....Graff C. (2012)
- High frequency of the TARDBP p.Ala382Thr mutation in Sardinian patients with amyotrophic lateral sclerosis. (PubMed id 21418058)1, 2 Orru S....Petersen M.B. (2011)
|
External Searches for TARDBP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TARDBP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TARDBP gene
(According to HUGE)
About This Section
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Specialized Databases showing TARDBP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TARDBP | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TARDBP gene:
Search GeneIP for patents involving TARDBP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TARDBP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TARDBP | | OriGene shRNA RFP for TARDBP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TARDBP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TARDBP | | | OriGene Protein Over-expression Lysate for TARDBP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TARDBP | | OriGene 3'-UTR Clone for TARDBP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARDBP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARDBP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TARDBP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TARDBP | | OriGene Custom Protein Services for TARDBP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TARDBP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TARDBP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TARDBP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TARDBP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TARDBP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TARDBP |
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| | Antibodies & Assays for TARDBP (TDP43) |
| | | | Search Tocris compounds for TARDBP |
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 | | | TARDBP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARDBP |
|  |  |  | | | | ThermoFisher Antibody for TARDBP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARDBP |
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