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TARDBP Gene

protein-coding   GIFtS: 62

GC01P011006
TAR DNA binding protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for TARDBP

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ALS10 2, 5
OTTHUMP00000002171 2
TDP-43 1, 2, 3
TDP43 3, 5
Descriptions
TAR DNA binding protein 2
TAR DNA-binding protein-43 2
External Ids
HGNC: 115711
Entrez Gene: 234352
UniProtKB: Q131483
Ensembl: ENSG000001209487
Search outside databases for aliases for TARDBP gene

Previous GC identifers: GC01P011033 GC01P010916 GC01P010682 GC01P010782

Summaries
for TARDBP

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for TARDBP:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome
that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1
gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located
downstream of the transcription initiation site. The protein encoded by this gene is a
transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1
transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar
pseudogene is present on chromosome 20. [provided by RefSeq]

UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148
Function: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the
regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs
in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is
associated with pathological features typical of cystic fibrosis. May also be involved in microRNA
biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1
long terminal repeat

Gene Wiki entry for TARDBP

Genomic Location
for TARDBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TARDBP gene  

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

TARDBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P011006:     (about GC identifiers)

Start:
 10,995,266 bp from pter
End:
 11,008,136 bp from pter
Size:
 12,871 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.9  NT_021937.18  

Proteins
for TARDBP

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148 (See protein sequence)
Recommended Name: TAR DNA-binding protein 43  
Size: 414 amino acids; 44740 Da
Subunit: Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated
sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous
repeats
Subcellular location: Nucleus. Note=Eliminated from nuclei of ubiquitinated inclusion-bearing
neurons in FTLDU
PDB structure from and Proteopedia :
1WF0 (3D)    2CQG (3D)    
Secondary accessions: Q6FI92 Q96DJ0

Post-translational modifications:

  • Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS
    and FTLDU1
  • Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and
    FTLDU1
  • Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from
    individuals affected with ALS and FTLDU1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_031401.1  

    ENSEMBL proteins: 
    ENSP00000240185 ENSP00000313129 ENSP00000323691 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TARDBP)
    Human Recombinant Proteins from Abnova (TARDBP)
                  OriGene Purified Recombinant Human Protein: TARDBP 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS7745706
    About this table

    Antibodies for TARDBP: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TARDBP
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TARDBP  (tdp43)
    Antibodies from Abcam (TARDBP), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TARDBP)
    Novus Biologicals Antibodies for TADBP

    Assays for TARDBP: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for TARDBP

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR000504 RRM_RNP1
     IPR012677 a_b_plait_nuc_bd


       GeneDecks  TARDBP for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q13148

    ProtoNet protein and cluster: Q13148

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148
    Similarity: Contains 2 RRM (RNA recognition motif) domains

    Gene Function
    for TARDBP

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TARDBP)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TARDBP)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007375

                  Applied Biosystems Silencer® siRNAs for TARDBP

                  Sigma-Aldrich siRNA for TARDBP  
                         Sigma-Aldrich shRNA for TARDBP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TARDBP
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007375
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007375
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_007375 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007375

    UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148
    Function: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the
    regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs
    in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is
    associated with pathological features typical of cystic fibrosis. May also be involved in microRNA
    biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1
    long terminal repeat

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003700 transcription factor activity TAS7745706 8599929
    GO:0003723 RNA binding IEA--
    GO:0005515 protein binding IPI15231747 18377426
    GO:0008017 microtubule binding TAS8599929
    About this table

    Pathways & Interactions
    for TARDBP

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/14 Interacting proteins for TARDBP (Q131481 ENSP000002401853) via UniProtKB, MINT, and/or STRING (see all 14 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC10Q017801EBI-372899, EBI-358236
    TOB1P506161EBI-372899, EBI-723281
    XRN2Q9H0D61EBI-372899, EBI-372110
    SNCAENSP000003383453STRING (score=.988)
    UBCENSP000003448183STRING (score=.966)
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006366 transcription from RNA polymerase II promoter TAS7745706
    GO:0006397 mRNA processing IEA--
    GO:0007067 mitosis TAS8599929
    About this table

    Drugs & Compounds
    for TARDBP

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TARDBP
    1 Novoseek chemical compound relationship for TARDBP gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    superoxide 10.37 3 18396105 (1), 19104447 (1)
    About this table


    Transcripts
    for TARDBP

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TARDBP)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TARDBP)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007375

                  Sigma-Aldrich siRNA for TARDBP  
                         Sigma-Aldrich shRNA for TARDBP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_007375  

    REFSEQ mRNAs for TARDBP gene: 

    NM_007375.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_007375  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007375
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007375
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_007375 

    Additional cDNA sequence: 

    AF311304.1 AK222754.1 AK295920.1 AK299454.1 AK312416.1 AL050265.1 BC001487.2 BC059955.1 
    BC071657.1 BC095435.1 CR533534.1 EF434181.1 EF434182.1 EF434183.1 U23731.1 

    24/35 DOTS entries (see all 35 ):

    DT.419641  DT.100882432  DT.100882435  DT.100882440  DT.121392100  DT.100882442  DT.97860226  DT.100032539 
    DT.91786971  DT.97856390  DT.100882434  DT.100882437  DT.91884354  DT.100038829  DT.100882443  DT.121392045 
    DT.100882429  DT.121392089  DT.40107291  DT.451822  DT.95143799  DT.105463  DT.121392036  DT.121392078 

    24/668 AceView cDNA sequences (see all 668 ):

    AI619451 AA367737 AL555909 CB144506 AA130324 BM765019 AI553677 AW070804 
    BU631375 BX342082 BQ229966 AU106011 BU521437 AU127433 AU128519 BF056843 
    BF221552 BF223379 BU684769 AI633034 BX422262 AV703589 BE466367 BU552536 

    highest scoring ESTs for TARDBP:

    AI143794 AI933665 AL050265 AA013401 AA025965 AA042859 AA044410 AA081839 AA125745 AA130325 

    Unigene Cluster for TARDBP:

    TAR DNA binding protein
    Hs.300624  [show with all ESTs]
    Unigene Representative Sequence: NM_007375


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000240185  ENST00000315091  ENST00000323644  

    Expression
    for TARDBP

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TARDBP expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TARDBP

    1 / 2 / 3

    9 probe-sets matching TARDBP gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    75426_at2, 3 U95-E 1 1.00 1.00 0.83 0.78 AI143794 1.00 1.00 1.00 1

    		59690_at2, 3 U95-B 1 1.00 1.00 0.80 0.95 N51697 0.80 1.00 0.91 1

    		32241_at2, 3 U95-A 2 1.00 0.53 0.49 1.16 AL050265 1.00 0.90 0.95 1

    		42364_at2, 3 U95-B 2 0.81 0.58 0.36 1.30 AI933665 1.00 1.00 1.00 1
    89349_at2, 3 U95-E 2 0.44 0.86 0.51 0.83 R08903 0.20 1.00 0.72 1

    		221264_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_031214 0.20 1.00 0.72 1

    		200020_at2, 3 U133-B 2 1.00 0.64 -- -- NM_007375 0.60 1.00 0.82 1

    		221264_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		200020_at2 U133Plus2 2 1.00 0.64 -- -- -- -- -- -- --
    GeneDecks  TARDBP for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAGATTCAGA

    SOURCE GeneReport for Unigene cluster: Hs.300624

    Expression variation in blood from EXPOLDB for TARDBP

    UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148
    Tissue specificity: Ubiquitously expressed. In particular, expression is high in pancreas,
    placenta, lung, genital tract and spleen

    Orthologs
    for TARDBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TARDBP gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 TARDBP1   -- TAR DNA binding protein 99.52(n)
    100(a)    		 457942  XM_001135199.1  XP_001135199.1 
    mouse
    (Mus musculus)    		 Tardbp1, 5 45
    		 TAR DNA binding protein1, 5 90.34(n)1
    96.14(a)1    		 2309081  NM_145556.31  NP_663531.11 
     AA1461955  AA9400365  (see all 45)
    chicken
    (Gallus gallus)    		 TARDBP1   -- TAR DNA binding protein 82.45(n)
    95.17(a)    		 419453  NM_001030878.1  NP_001026049.1 
    zebrafish
    (Danio rerio)    		 wufb77f022   -- Danio rerio mRNA similar to TAR DNA binding protein more 75.89(n)  BC049348.1 
    fruit fly
    (Drosophila melanogaster)    		 TBPH1, 3 60A4--53
    		 RNA binding3
    TBPH1    		 56(a)
    (best of 2)3
    53.17(n)1
    50.79(a)1    		 377811  NM_058052.21  NP_477400.11 
    About this table        Species with no ortholog for TARDBP

    ENSEMBL Gene Tree for TARDBP

    Paralogs
    for TARDBP

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TARDBP gene
    DAZAP12  

    Pseudogenes
    5 related pseudogenes


    SNPs/Variants
    for TARDBP

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/77 NCBI SNPs in TARDBP are shown (see all 77 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs9685451,2
    		C,F,H,O10995166(-) AATTCG/AAGCCT 1 -- ng5114Minor allele frequency- A:0.02NA MN EU EA WA 1198
    rs94303351,2
    		C,F,H10994704(+) aatagT/Ctcctg 1 -- ng512Minor allele frequency- C:0.18EU WA 212
    --
    rs120299681,2
    		A10993318(+) AGCAAC/TGTGAA 1 -- ng510--------
    --
    rs115477361,2
    		C10999524(+) TTCATA/CAGCAG 1 S/X non10--------
    --
    rs94301721,2
    		A10993506(+) ctcagG/Taggct 1 -- ng510--------
    rs75409031,2
    		A,C,F,H11001312(+) GAACTA/GTGATT 1 -- int14Minor allele frequency- G:0.05EU EA WA 410
    rs37658961,2
    		A,C,F,H10997007(+) AATGAA/GCAAAC 1 -- int112Minor allele frequency- G:0.14NA EA EU WA 1102
    rs37658971,2
    		C,F,H10997169(+) TCAGCA/GTTTTG 1 -- int116Minor allele frequency- G:0.15EA NA EU WA 2898
    rs75436051,2
    		A,F,H11001799(+) CTTACA/GTAGTT 1 -- int14Minor allele frequency- G:0.01EU EA WA 392
    rs37658951,2
    		C,F,H10996837(+) AATAAG/ACTTTG 1 -- int19Minor allele frequency- A:0.13EA EU WA 2132
    About this table

    HapMap Linkage Disequilibrium images for TARDBP (up to first 250kb)

    Disorders & Mutations
    for TARDBP

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 605078   disorders: 612069  

    UniProtKB/Swiss-Prot: TADBP_HUMAN, Q13148

  • Defects in TARDBP are a cause of amyotrophic lateral sclerosis type 10 (ALS10)
    [MIM:612069]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and
    resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5
    years. The etiology of ALS is likely to be multifactorial, involving both genetic and
    environmental factors. TARDBP is the primary component of ubiquitin-positive inclusion bodies
    found in ALS and in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLDU)

    • 10 Novoseek disease relationships for TARDBP gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    frontotemporal dementia 95.47 79 18989115 (3), 18087705 (2), 18535185 (2), 19350673 (2) (see all 49)
    amyotrophic lateral sclerosis 89.93 89 18989115 (4), 18396105 (2), 18802454 (2), 19104447 (2) (see all 46)
    motor neuron disease 81.98 11 18087705 (2), 18288693 (1), 17492294 (1), 18755042 (1) (see all 8)
    inclusion body myopathy 79.92 2 18796596 (2)
    neurodegenerative diseases 72.75 20 18802454 (2), 18929508 (2), 18288693 (1), 18549326 (1) (see all 10)
    picks disease 71.43 2 18091558 (1), 18607609 (1)
    neurodegeneration 70.95 25 18396105 (2), 17898224 (2), 18634762 (1), 18802454 (1) (see all 12)
    dementia 60.77 9 19112176 (1), 17653732 (1), 18505686 (1), 19329383 (1)
    alzheimers disease 51.29 14 18634762 (2), 18592255 (2), 18929508 (1), 17653732 (1) (see all 9)
    neurofibrillary tangles 33.32 1 18592255 (1)
    About this table

    GeneTests: TARDBP
    Amyotrophic Lateral Sclerosis

    Human Gene Mutation Database: TARDBP
    Human Genome Epidemiology Navigator: TARDBP (9 documents)

    Medical News
    for TARDBP

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for TARDBP

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/146 PubMed articles for TARDBP gene (see all 146 ):

    Search for TARDBP

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TARDBP

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 23435 HGNC: 11571 AceView: TARDBP Ensembl:ENSG00000120948 euGenes: HUgn23435
    ECgene: TARDBP H-InvDB: TARDBP

    Other Databases showing TARDBP

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing TARDBP

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for TARDBP

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for TARDBP

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TARDBP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TARDBP-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TARDBP Antibodies for TARDBP
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TARDBP Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies & Assays for TARDBP  (tdp43)

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     Antibodies for TADBP

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