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TARBP2 Gene

protein-coding   GIFtS: 59
GCID: GC12P053890

TAR (HIV-1) RNA Binding Protein 2

(Previous name: Tar (HIV-1) RNA binding protein 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAR (HIV-1) RNA Binding Protein 21 2     RISC-Loading Complex Subunit TARBP22
Trans-Activation-Responsive RNA-Binding Protein2 3     TAR (HIV) RNA Binding Protein 22
TRBP2 3     TAR (HIV) RNA-Binding Protein 22
TAR RNA-Binding Protein 22 3     TAR (HIV) RNA-Binding Protein TRBP12
LOQS2     TAR RNA Binding Protein 22
TRBP12     Trans-Activation Responsive RNA-Binding Protein2
TRBP22     

External Ids:    HGNC: 115691   Entrez Gene: 68952   Ensembl: ENSG000001395467   OMIM: 6050535   UniProtKB: Q156333   

Export aliases for TARBP2 gene to outside databases

Previous GC identifers: GC12P054007 GC12P053611 GC12P052181 GC12P052182 GC12P052183 GC12P050934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TARBP2 Gene:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a
chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the
transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription
initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA
regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative
splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TARBP2 Gene:
TARBP2 (TAR (HIV-1) RNA binding protein 2) is a protein-coding gene. Diseases associated with TARBP2 include pleuropulmonary blastoma, and acquired immunodeficiency syndrome. GO annotations related to this gene include siRNA binding and protein homodimerization activity. An important paralog of this gene is PRKRA.

UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading
complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and
TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature
miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may
subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs
(siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long
terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at
least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of
EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR

Gene Wiki entry for TARBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TARBP2 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTARBP2 promoter sequence
   Search Chromatin IP Primers for TARBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TARBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

TARBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARBP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053890:  view genomic region     (about GC identifiers)

Start:
53,894,705 bp from pter      End:
53,900,215 bp from pter
Size:
5,511 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633 (See protein sequence)
Recommended Name: RISC-loading complex subunit TARBP2  
Size: 366 amino acids; 39039 Da
Subunit: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex
(miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as
RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and
PRKRA. Associates with the 60S ribosome
3 PDB 3D structures from and Proteopedia for TARBP2:
2CPN (3D)        3ADL (3D)        3LLH (3D)    
Secondary accessions: Q12878 Q8WY32 Q8WY33 Q9BRY2
Alternative promoter usage: 2 isoforms:  Q15633-1   Q15633-2   

Explore the universe of human proteins at neXtProt for TARBP2: NX_Q15633

Explore proteomics data for TARBP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TARBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004169.3  NP_599150.1  NP_599151.2  

    ENSEMBL proteins: 
     ENSP00000450320   ENSP00000266987   ENSP00000416077   ENSP00000449537   ENSP00000447993  
     ENSP00000448199   ENSP00000447262   ENSP00000458011   ENSP00000448948   ENSP00000448943  
     ENSP00000377885   ENSP00000447767  
    Reactome Protein details: Q15633

    TARBP2 Human Recombinant Protein Products:

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    Novus Biologicals TARBP2 Proteins
    Novus Biologicals TARBP2 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TARBP2

    TARBP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TARBP2
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    Abcam antibodies for TARBP2
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    ThermoFisher Antibodies for TARBP2
    LSBio Antibodies in human, mouse, rat for TARBP2

    TARBP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TARBP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TARBP2
    Cloud-Clone Corp. CLIAs for TARBP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028605 TRBP2
     IPR014720 dsRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q15633

    ProtoNet protein and cluster: Q15633

    UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
    Similarity: Belongs to the TARBP2 family
    Similarity: Contains 3 DRBM (double-stranded RNA-binding) domains


    TARBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRBP2_HUMAN, Q15633
    Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading
    complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and
    TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature
    miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may
    subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs
    (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long
    terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at
    least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of
    EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR

         Genatlas biochemistry entry for TARBP2:
    TAR region of HIV-1,RNA binding protein 2,homolog of mouse protamine RNA binding protein

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IEA--
    GO:0005515protein binding IPI15973356
    GO:0035197siRNA binding IDA15973356
    GO:0035198miRNA binding IEA--
    GO:0042803protein homodimerization activity IPI17452327
         
    TARBP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TARBP2:
     Decreased cell number 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tarbp2):
     growth/size/body  mortality/aging  reproductive system 

    TARBP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tarbp2tm1Reb for TARBP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TARBP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TARBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TARBP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TARBP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TARBP2:
    hsa-mir-26b-5p (MIRT029188), hsa-mir-98-5p (MIRT027513)

    Block miRNA regulation of human, mouse, rat TARBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TARBP2 (see all 23):
    hsa-miR-34b* hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTARBP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TARBP2
    Predesigned siRNA for gene silencing in human, mouse, rat TARBP2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TARBP2

    Clone
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    OriGene clones in human, mouse for TARBP2 (see all 16)
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    GenScript: all cDNA clones in your preferred vector (see all 3): TARBP2 (NM_134324)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TARBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARBP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TARBP2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARBP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRBP2_HUMAN, Q15633: Cytoplasm. Cytoplasm, perinuclear region. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA17452327
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IDA15973356
    GO:0048471perinuclear region of cytoplasm IEA--

    TARBP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TARBP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulatory RNA pathways
    Regulatory RNA pathways0.88
    Small Interfering RNA (siRNA) Biogenesis0.00
    MicroRNA (miRNA) Biogenesis0.88
    2Gene Expression
    Gene Expression0.40
    3RNAi Pathway
    RNAi Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TARBP2
        RNAi Pathway

    2 Reactome Pathways for TARBP2
        MicroRNA (miRNA) biogenesis
    Small interfering RNA (siRNA) biogenesis



    TARBP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TARBP2
    Interactions:

        GeneGlobe Interaction Network for TARBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TARBP2 (Q156331, 2, 3 ENSP000002669874) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKRAO755691, 2, 3, ENSP000003181764EBI-978581,EBI-713955 MINT-1958051 MINT-8267435 I2D: score=3 STRING: ENSP00000318176
    DICER1Q9UPY31, 2, 3, ENSP000003437454EBI-978581,EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 I2D: score=7 STRING: ENSP00000343745
    AGO2Q9UKV81, 2, 3, ENSP000002205924EBI-978581,EBI-528269 MINT-6489217 MINT-1957947 I2D: score=2 STRING: ENSP00000220592
    EIF2AK2P195251, 3, ENSP000002330574EBI-978581,EBI-640775 I2D: score=3 STRING: ENSP00000233057
    RBM14Q96PK63, ENSP000003117474I2D: score=3 STRING: ENSP00000311747
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS8723388
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS2011739
    GO:0006417regulation of translation IEA--
    GO:0006469negative regulation of protein kinase activity TAS11641396
    GO:0010467gene expression TAS--

    TARBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TARBP2 (TRBP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TARBP2 gene (3 alternative transcripts): 
    NM_004178.4  NM_134323.1  NM_134324.2  

    Unigene Cluster for TARBP2:

    TAR (HIV-1) RNA binding protein 2
    Hs.326  [show with all ESTs]
    Unigene Representative Sequence: BC002419
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000550147(uc001sdr.3) ENST00000266987(uc001sdp.3 uc001sdo.3)
    ENST00000456234 ENST00000552857 ENST00000549610(uc009znb.3) ENST00000546889
    ENST00000548971 ENST00000547388 ENST00000552650 ENST00000547064 ENST00000551741
    ENST00000552817 ENST00000549028 ENST00000549572(uc001sdt.3) ENST00000549679
    ENST00000394357 ENST00000550407 ENST00000551157
    miRNA
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    Block miRNA regulation of human, mouse, rat TARBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TARBP2 (see all 23):
    hsa-miR-34b* hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTARBP2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): TARBP2 (NM_134324)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TARBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARBP2
    Primer
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    OriGene qPCR primer pairs and template standards for TARBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for TARBP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TARBP2
      QuantiTect SYBR Green Assays in human, mouse, rat TARBP2
      QuantiFast Probe-based Assays in human, mouse, rat TARBP2

    Additional mRNA sequence: 

    AB593181.1 AK290737.1 AK293728.1 AK309569.1 BC002419.2 BC005860.2 BT007140.1 M60801.1 
    U08998.2 

    18 DOTS entries:

    DT.214193  DT.95097655  DT.91893144  DT.121195741  DT.91745147  DT.100822639  DT.75178382  DT.100800279 
    DT.102831590  DT.102831589  DT.121195766  DT.100822643  DT.100662998  DT.100763316  DT.121195774  DT.95097640 
    DT.100822640  DT.121195755 

    Selected AceView cDNA sequences (see all 218):

    CR610050 BM562104 CR619705 BQ011029 BX344718 CR606778 AW087235 NM_134323 
    CD672162 CR613878 CR599054 BX339599 BC002419 BQ881609 BX375921 CD672161 
    BQ436002 AI318049 BU956616 NM_134324 CR602082 CB116463 BQ673893 BU859959 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TARBP2 (see all 27)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a ·
    SP1:                                                                    -     -     -     -                 -     -           -     -     -     -     -     -   
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -     -                 -     -           -     -     -     -     -     -   
    SP3:                                                                    -     -     -     -                 -     -           -     -     -     -     -     -   
    SP4:                                                                                                        -     -                 -     -     -     -     -   
    SP5:                                                                                                        -     -           -     -     -     -     -     -   

    ExUns: 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12a · 12b · 12c · 12d
    SP1:  -     -           -                                                                                                   
    SP2:  -                 -                                                                                                   
    SP3:  -                 -                                                                                                   
    SP4:  -     -           -                                                                                                   
    SP5:  -     -           -                                                                                                   


    ECgene alternative splicing isoforms for TARBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TARBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGCGCA
    TARBP2 Expression
    About this image

    TARBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TARBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326
        Custom PCR Arrays for TARBP2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TARBP2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tarbp21 , 5 TAR (HIV) RNA binding protein 21, 5 89.95(n)1
    94.79(a)1
      15 (57.65 cM)5
    213571  NM_009319.31  NP_033345.21 
     1025181925 
    lizard
    (Anolis carolinensis)
    Reptilia TARBP26
    TAR (HIV-1) RNA binding protein 2
    75(a)
    1 ↔ 1
    2(73133323-73151914)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37342 Xenopus laevis transcribed sequence with weak similarity more 75.53(n)    CB209671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj51e122 wufj51e12 76.43(n)   336141  BC055390.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta loqs6
    loquacious
    26(a)
    1 → many
    2L(13382648-13385671)


    ENSEMBL Gene Tree for TARBP2 (if available)
    TreeFam Gene Tree for TARBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TARBP2 gene
    PRKRA2  
    6 SIMAP similar genes for TARBP2 using alignment to 11 protein entries:     TRBP2_HUMAN (see all proteins):
    PRKRA    ADAR    DGCR8    STAU2    STAU2 variant protein    STAU1

    TARBP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TARBP2
    PGOHUM00000249766


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TARBP2 (see all 103)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128158791,2
    C,H--50932296(+) GTGCTC/ATCTGA 2 -- us2k14Minor allele frequency- A:0.00NS EA 416
    rs57982671,2
    C--53895601(+) TTCTTC/-CCCCC 3 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs1862530231,2
    C--53895749(+) GCTAGA/GTGGGT 3 -- int10--------
    rs2005366801,2
    --53895787(+) TGTGCC/TCCTTC 3 -- int10--------
    rs1383142251,2
    C,F--53895829(+) CCAGGC/AAAGAC 6 /G syn12Minor allele frequency- A:0.00NA EU 5875
    rs1438140541,2
    C--53895904(+) AAAGCC/TGAGGG 6 A syn11Minor allele frequency- T:0.00NA 4550
    rs1485659921,2
    --53896044(+) TCTCTC/TTTCAC 3 -- int10--------
    rs1908185201,2
    --53896305(+) CAAATC/TCCCGT 3 -- int10--------
    rs1124755411,2
    F--53896382(+) CCGCCT/CGCCCA 3 -- int13Minor allele frequency- C:0.40CSA 5
    rs597977811,2
    C,F--53896453(+) CTAGTA/GTGTGG 3 -- int12Minor allele frequency- G:0.03WA 120

    HapMap Linkage Disequilibrium report for TARBP2 (53894705 - 53900215 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TARBP2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TARBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TARBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605053    OMIM disorders: --

    13 diseases for TARBP2:    
    About MalaCards
    pleuropulmonary blastoma    acquired immunodeficiency syndrome    hiv-1    shipyard eye
    blastoma    esophageal cancer    renal cell carcinoma    esophagitis
    pancreatic cancer    pancreatitis    colorectal cancer    sarcoma
    malaria

    2 diseases from the University of Copenhagen DISEASES database for TARBP2:
    Shipyard eye     Pleuropulmonary blastoma

    TARBP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TARBP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 54.5 12 8455607 (2), 17360756 (2), 7515177 (1), 9060615 (1) (see all 9)
    tumors 0 3 19219043 (1), 19804757 (1)

    Genetic Association Database (GAD): TARBP2
    Human Genome Epidemiology (HuGE) Navigator: TARBP2 (5 documents)

    Export disorders for TARBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TARBP2 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with TARBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. (PubMed id 2011739)1, 2, 3, 9 Gatignol A.... Jeang K.T. (Science 1991)
    2. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. (PubMed id 11641396)1, 2, 9 Bannwarth S.... Gatignol A. (J. Biol. Chem. 2001)
    3. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. (PubMed id 11438532)1, 2, 9 Daher A....Gatignol A. (J. Biol. Chem. 2001)
    4. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. (PubMed id 19219043)1, 2, 9 Melo S.A.... Esteller M. (Nat. Genet. 2009)
    5. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. (PubMed id 15973356)1, 2, 9 Chendrimada T.P.... Shiekhattar R. (Nature 2005)
    6. Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. (PubMed id 8455607)1, 2, 9 Gatignol A.... Jeang K.T. (Mol. Cell. Biol. 1993)
    7. The role of PACT in the RNA silencing pathway. (PubMed id 16424907)1, 2, 9 Lee Y.... Kim V.N. (EMBO J. 2006)
    8. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). (PubMed id 7774957)1, 2, 9 Kozak C.A.... McBride O.W. (Genomics 1995)
    9. A human, ATP-independent, RISC assembly machine fueled by pre- miRNA. (PubMed id 16357216)1, 2, 9 Maniataki E. and Mourelatos Z. (Genes Dev. 2005)
    10. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1, 4 Lin J....Wu X. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6895 HGNC: 11569 AceView: TARBP2 Ensembl:ENSG00000139546 euGenes: HUgn6895
    ECgene: TARBP2 H-InvDB: TARBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TARBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TARBP2 gene:
    Search GeneIP for patents involving TARBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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