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Aliases for TARBP2 Gene

Aliases for TARBP2 Gene

  • TARBP2, RISC Loading Complex RNA Binding Subunit 2 3 5
  • TAR (HIV-1) RNA Binding Protein 2 2 3
  • TRBP 3 4
  • Trans-Activation Responsive RNA-Binding Protein 3
  • Trans-Activation-Responsive RNA-Binding Protein 4
  • RISC-Loading Complex Subunit TARBP2 3
  • TAR (HIV) RNA-Binding Protein TRBP1 3
  • TAR (HIV) RNA-Binding Protein 2 3
  • TAR RNA Binding Protein 2 3
  • TAR RNA-Binding Protein 2 4
  • TRBP1 3
  • TRBP2 3
  • LOQS 3

External Ids for TARBP2 Gene

Previous GeneCards Identifiers for TARBP2 Gene

  • GC12P053890
  • GC12P054007
  • GC12P053611
  • GC12P052181
  • GC12P052182
  • GC12P052183
  • GC12P050934

Summaries for TARBP2 Gene

Entrez Gene Summary for TARBP2 Gene

  • HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TARBP2 Gene

TARBP2 (TARBP2, RISC Loading Complex RNA Binding Subunit) is a Protein Coding gene. Diseases associated with TARBP2 include Hiv-1. Among its related pathways are Translational Control and mRNA Capping. GO annotations related to this gene include protein homodimerization activity and double-stranded RNA binding. An important paralog of this gene is PRKRA.

UniProtKB/Swiss-Prot for TARBP2 Gene

  • Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Gene Wiki entry for TARBP2 Gene

Additional gene information for TARBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARBP2 Gene

Genomics for TARBP2 Gene

Regulatory Elements for TARBP2 Gene

Enhancers for TARBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H052894 2 FANTOM5 Ensembl ENCODE dbSUPER 20.7 -597.3 -597276 16 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D AAAS ZNF740 PCBP2 SP1 MAP3K12 LOC100652999 ATF7 CALCOCO1 EIF4B ENSG00000257808
GH12H053664 0.9 dbSUPER 38 +164.5 164491 0 ZFP64 ZNF138 ZNF366 ZNF354C KLF7 ZNF202 ZNF654 ZNF680 ZC3H11A REST HNRNPA1 ZNF740 ATF7 AAAS TARBP2 ATP5G2 ENSG00000258344 CBX5 CSAD SP1
GH12H054130 1.1 ENCODE dbSUPER 21 +634.6 634561 8 FOXA2 ZSCAN4 KLF17 FEZF1 RAD21 RARA ZNF121 MIXL1 EGR2 ZNF654 FLJ12825 TARBP2 SMUG1 MIR615 HOXC4 HOXC5 HOXC6 ENSG00000260470 HOXC8 HOXC-AS2
GH12H054160 1 ENCODE 21.4 +661.3 661286 1 HDGF PKNOX1 ATF1 ZNF133 ZNF2 ZNF121 GLIS2 ATF7 SP3 CAVIN1 ZNF740 ATF7 HNRNPA1 PCBP2 ENSG00000258344 LOC100652999 MAP3K12 AAAS TARBP2 CALCOCO1
GH12H053971 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +490.0 490040 36 PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZNF766 ZNF416 ZNF207 HNRNPA1 ZNF740 ENSG00000258344 ATF7 PCBP2 MAP3K12 LOC100652999 SP1 CALCOCO1 AAAS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TARBP2 on UCSC Golden Path with GeneCards custom track

Promoters for TARBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052203 97 2601 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Transcription factor binding sites by QIAGEN in the TARBP2 gene promoter:

Genomic Location for TARBP2 Gene

Chromosome:
12
Start:
53,500,203 bp from pter
End:
53,506,431 bp from pter
Size:
6,229 bases
Orientation:
Plus strand

Genomic View for TARBP2 Gene

Genes around TARBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARBP2 Gene

Proteins for TARBP2 Gene

  • Protein details for TARBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15633-TRBP2_HUMAN
    Recommended name:
    RISC-loading complex subunit TARBP2
    Protein Accession:
    Q15633
    Secondary Accessions:
    • Q12878
    • Q8WY32
    • Q8WY33
    • Q9BRY2

    Protein attributes for TARBP2 Gene

    Size:
    366 amino acids
    Molecular mass:
    39039 Da
    Quaternary structure:
    • Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

    Three dimensional structures from OCA and Proteopedia for TARBP2 Gene

    Alternative splice isoforms for TARBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARBP2 Gene

Post-translational modifications for TARBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TARBP2 (TRBP)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TARBP2

No data available for DME Specific Peptides for TARBP2 Gene

Domains & Families for TARBP2 Gene

Gene Families for TARBP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TARBP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TARBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15633

UniProtKB/Swiss-Prot:

TRBP2_HUMAN :
  • Belongs to the TARBP2 family.
Family:
  • Belongs to the TARBP2 family.
genes like me logo Genes that share domains with TARBP2: view

Function for TARBP2 Gene

Molecular function for TARBP2 Gene

GENATLAS Biochemistry:
TAR region of HIV-1,RNA binding protein 2,homolog of mouse protamine RNA binding protein
UniProtKB/Swiss-Prot Function:
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Phenotypes From GWAS Catalog for TARBP2 Gene

Gene Ontology (GO) - Molecular Function for TARBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA,IEA 23661684
GO:0005515 protein binding IPI 15973356
GO:0019899 enzyme binding IPI 25557550
GO:0035197 siRNA binding IDA,IEA 15973356
GO:0036002 pre-mRNA binding TAS 19820710
genes like me logo Genes that share ontologies with TARBP2: view
genes like me logo Genes that share phenotypes with TARBP2: view

Animal Models for TARBP2 Gene

MGI Knock Outs for TARBP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TARBP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TARBP2 Gene

Localization for TARBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARBP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TARBP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TARBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 17452327
GO:0005829 cytosol TAS --
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with TARBP2: view

Pathways & Interactions for TARBP2 Gene

genes like me logo Genes that share pathways with TARBP2: view

Pathways by source for TARBP2 Gene

1 Cell Signaling Technology pathway for TARBP2 Gene
1 BioSystems pathway for TARBP2 Gene

SIGNOR curated interactions for TARBP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for TARBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006469 negative regulation of protein kinase activity TAS 11641396
GO:0007286 spermatid development IEA --
GO:0007338 single fertilization IEA --
GO:0010586 miRNA metabolic process TAS --
genes like me logo Genes that share ontologies with TARBP2: view

Drugs & Compounds for TARBP2 Gene

No Compound Related Data Available

Transcripts for TARBP2 Gene

Unigene Clusters for TARBP2 Gene

TAR (HIV-1) RNA binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TARBP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TARBP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - - - - - - - -
SP20: - - - - - -
SP21: - - - - - -
SP22: - - - - - -
SP23: - -
SP24: - -
SP25:
SP26: - - - - - - - -
SP27: - - - -

ExUns: 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12a · 12b · 12c · 12d
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - - - - -
SP9: - -
SP10: - -
SP11: - -
SP12: -
SP13: - -
SP14: - - -
SP15: - - -
SP16: -
SP17: - -
SP18: -
SP19: - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - -
SP26:
SP27:

Relevant External Links for TARBP2 Gene

GeneLoc Exon Structure for
TARBP2
ECgene alternative splicing isoforms for
TARBP2

Expression for TARBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TARBP2 Gene

Protein differential expression in normal tissues from HIPED for TARBP2 Gene

This gene is overexpressed in Lung (35.1) and Retina (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TARBP2 Gene



Protein tissue co-expression partners for TARBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TARBP2 Gene:

TARBP2

SOURCE GeneReport for Unigene cluster for TARBP2 Gene:

Hs.326

Evidence on tissue expression from TISSUES for TARBP2 Gene

  • Liver(4.4)
  • Muscle(4.4)
  • Nervous system(2.9)
  • Urine(2.5)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TARBP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TARBP2 Gene

Orthologs for TARBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TARBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TARBP2 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia TARBP2 33 34
  • 93.08 (n)
dog
(Canis familiaris)
Mammalia TARBP2 33 34
  • 91.8 (n)
mouse
(Mus musculus)
Mammalia Tarbp2 33 16 34
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia Tarbp2 33
  • 89.04 (n)
lizard
(Anolis carolinensis)
Reptilia TARBP2 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tarbp2 33
  • 70.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3734 33
zebrafish
(Danio rerio)
Actinopterygii tarbp2 33 34
  • 65.32 (n)
wufj51e12 33
fruit fly
(Drosophila melanogaster)
Insecta loqs 34
  • 26 (a)
OneToMany
Species where no ortholog for TARBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TARBP2 Gene

ENSEMBL:
Gene Tree for TARBP2 (if available)
TreeFam:
Gene Tree for TARBP2 (if available)

Paralogs for TARBP2 Gene

Paralogs for TARBP2 Gene

Pseudogenes.org Pseudogenes for TARBP2 Gene

genes like me logo Genes that share paralogs with TARBP2: view

Variants for TARBP2 Gene

Sequence variations from dbSNP and Humsavar for TARBP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000102741 -- 53,506,644(+) CCTTG(A/G)GCTTC downstream-variant-500B
rs1000310038 -- 53,502,657(+) ATGGT(A/C)ACATG intron-variant, upstream-variant-2KB
rs1000863261 -- 53,502,002(+) CTGTG(-/CCC)CTTCC intron-variant, upstream-variant-2KB
rs1001356107 -- 53,499,173(+) CAATA(C/T)GGTCC intron-variant, upstream-variant-2KB
rs1001745048 -- 53,503,420(+) ACATA(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TARBP2 Gene

Variant ID Type Subtype PubMed ID
nsv983486 CNV duplication 23825009

Variation tolerance for TARBP2 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TARBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TARBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARBP2 Gene

Disorders for TARBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TARBP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TARBP2

Genetic Association Database (GAD)
TARBP2
Human Genome Epidemiology (HuGE) Navigator
TARBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TARBP2
genes like me logo Genes that share disorders with TARBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TARBP2 Gene

Publications for TARBP2 Gene

  1. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. (PMID: 2011739) Gatignol A … Jeang KT (Science (New York, N.Y.) 1991) 2 3 4 22 60
  2. The role of PACT in the RNA silencing pathway. (PMID: 16424907) Lee Y … Kim VN (The EMBO journal 2006) 3 4 22 60
  3. A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. (PMID: 16357216) Maniataki E … Mourelatos Z (Genes & development 2005) 3 4 22 60
  4. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. (PMID: 15973356) Chendrimada TP … Shiekhattar R (Nature 2005) 3 4 22 60
  5. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. (PMID: 11641396) Bannwarth S … Gatignol A (The Journal of biological chemistry 2001) 3 4 22 60

Products for TARBP2 Gene

Sources for TARBP2 Gene

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