TARBP2 Gene
protein-coding GIFtS: 56
GCID: GC12P053890
|
|
TAR (HIV-1) RNA binding protein 2(Previous name: Tar (HIV-1) RNA binding protein 2 )
| |
Aliases
for TARBP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAR (HIV-1) RNA Binding Protein 21 2 | | RISC-Loading Complex Subunit TARBP22 | | Trans-Activation-Responsive RNA-Binding Protein2 3 | | TAR (HIV) RNA Binding Protein 22 | | TRBP2 3 | | TAR (HIV) RNA-Binding Protein 22 | | TAR RNA-Binding Protein 22 3 | | TAR (HIV) RNA-Binding Protein TRBP12 | | LOQS2 | | TAR RNA Binding Protein 22 | | TRBP12 | | Trans-Activation Responsive RNA-Binding Protein2 | | TRBP22 | | |
Export aliases for TARBP2 gene to outside databasesPrevious GC identifers: GC12P054007 GC12P053611 GC12P052181 GC12P052182 GC12P052183 GC12P050934 |
Summaries
for TARBP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TARBP2:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces achromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivatorTat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. Theprotein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element andactivates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multipletranscript variants encoding different isoforms. This gene also has a pseudogene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex(RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 andTARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAsand then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and maysubsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs(siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminalrepeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by bindingto and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promotetranslation of TAR-containing RNAs independently of EIF2AK2/PKR
Gene Wiki entry for TARBP2
|
Genomic Views
for TARBP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TARBP2 gene promoter:
Sp1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TARBP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TARBP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q12-q13 Ensembl cytogenetic band: 12q13.13 HGNC chromosome: 12TARBP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P053890: view genomic region
(about GC identifiers)
Start:
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53,894,705 bp from pter |
End:
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53,900,215 bp from pter |
Size:
|
5,511 bases |
Orientation:
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plus strand |
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Proteins
for TARBP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633 (See
protein sequence)Recommended Name: RISC-loading complex subunit TARBP2 Size: 366 amino acids; 39039 Da
Subunit: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC),which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and PRKRA.Associates with the 60S ribosome
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus
3 PDB 3D structures from  and Proteopedia  for TARBP2:2CPN (3D)
3ADL (3D)
3LLH (3D)
Secondary accessions: Q12878 Q8WY32 Q8WY33 Q9BRY2Alternative promoter usage: 2 isoforms: Q15633-1 Q15633-2 Explore the universe of human proteins at neXtProt for TARBP2: NX_Q15633
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15633
TARBP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_004169.3 NP_599150.1 NP_599151.2
ENSEMBL proteins: ENSP00000450320 ENSP00000266987 ENSP00000416077 ENSP00000449537 ENSP00000447993 ENSP00000448199 ENSP00000447262 ENSP00000458011 ENSP00000448948 ENSP00000448943 ENSP00000377885 ENSP00000447767 Reactome Protein details: Q15633
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TARBP2 for ontologies About GeneDecksing
TARBP2 Antibody Products:
Assay Products for TARBP2: |
Protein
Domains /
Families
for TARBP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TARBP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15633ProtoNet protein and cluster: Q15633 UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633Similarity: Contains 3 DRBM (double-stranded RNA-binding) domains |
Function
for TARBP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex(RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 andTARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAsand then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and maysubsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs(siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminalrepeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by bindingto and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promotetranslation of TAR-containing RNAs independently of EIF2AK2/PKR Genatlas biochemistry entry for TARBP2:TAR region of HIV-1,RNA binding protein 2,homolog of mouse protamine RNA binding protein
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARBP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARBP2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TARBP2 (NM_134324) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TARBP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARBP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARBP2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TARBP2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TARBP2:
Animal Models:
Mouse knock-out Tarbp2tm1Reb for TARBP2
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tarbp2):
TARBP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TARBP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Duplex siRNA is loaded into Argonaute | | | 2 | Regulatory RNA pathways | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TARBP2
5/6 
Reactome Pathways for TARBP2 (see all 6)
TARBP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TARBP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/84 Interacting proteins for TARBP2 (Q156331, 2, 3 ENSP000002669874) via UniProtKB, MINT, STRING, and/or I2D (see all 84)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PRKRA | O755692, 3, ENSP000003181764 | MINT-1958051 MINT-8267435 I2D:
score=3 STRING: ENSP00000318176 | | DICER1 | Q9UPY31, 2, 3, ENSP000003437454 | EBI-978581,EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 I2D:
score=7 STRING: ENSP00000343745 | | AGO2 | Q9UKV82, 3, ENSP000002205924 | MINT-6489217 MINT-1957947 I2D:
score=2 STRING: ENSP00000220592 | | EIF2AK2 | P195251, 3, ENSP000002330574 | EBI-978581,EBI-640775 I2D:
score=3 STRING: ENSP00000233057 | | RBM14 | Q96PK63, ENSP000003117474 | I2D:
score=3 STRING: ENSP00000311747 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
TARBP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TARBP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TARBP2
Search CenterWatch for drugs/clinical trials and news about TARBP2 / TRBP2
|
Transcripts
for TARBP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TARBP2 gene (3 alternative transcripts): NM_004178.4 NM_134323.1 NM_134324.2 Unigene Cluster for TARBP2: TAR (HIV-1) RNA binding protein 2 Hs.326 [show with all ESTs]Unigene Representative Sequence: BC00241918/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000550147(uc001sdr.3) ENST00000266987(uc001sdp.3 uc001sdo.3)
ENST00000456234 ENST00000552857 ENST00000549610(uc009znb.3) ENST00000546889
ENST00000548971 ENST00000547388 ENST00000552650 ENST00000547064 ENST00000551741
ENST00000552817 ENST00000549028 ENST00000549572(uc001sdt.3) ENST00000549679
ENST00000394357 ENST00000550407 ENST00000551157
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARBP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARBP2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TARBP2 (NM_134324) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TARBP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARBP2 |
Additional cDNA sequence: AB593181.1 AK290737.1 AK293728.1 AK309569.1 BC002419.2 BC005860.2 BT007140.1 M60801.1 U08998.2 18 DOTS entries: DT.214193 DT.95097655 DT.91893144 DT.121195741 DT.91745147 DT.100822639 DT.75178382 DT.100800279 DT.102831590 DT.102831589 DT.121195766 DT.100822643 DT.100662998 DT.100763316 DT.121195774 DT.95097640 DT.100822640 DT.121195755 24/218 AceView cDNA sequences (see all 218): BU070521 CR608491 BI771121 BF724259 BQ011029 BF035358 BX344718 CR626705 AW087235 BM724858 CR606778 CR606145 NM_134323 BU182878 BX396298 BX417745 CA421368 CB116463 CR608571 BX375921 AW015160 CR619705 CR602082 CR626085
GeneLoc Exon Structure
5/27 Alternative Splicing Database (ASD) splice patterns (SP) for TARBP2 (see all 27) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | · | 2h | · | 2i | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | |
| ExUns: | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|
|
| SP1: | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TARBP2
|
Expression
for TARBP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TARBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTGCGCA
About this image
See TARBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TARBP2
SOURCE GeneReport for Unigene cluster: Hs.326
SABiosciences Custom PCR Arrays for TARBP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TARBP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TARBP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TARBP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TARBP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARBP2 |
Orthologs
for TARBP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TARBP2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TARBP26 |
-- |
75(a) |
1 ↔ 1 |
2(73136926-73149357) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.37342 |
Xenopus laevis transcribed sequence with weak similarity more |
75.53(n) |
|
CB209671.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj51e122 |
wufj51e12 |
76.43(n) |
|
336141 BC055390.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
loqs1 |
loquacious |
47.46(n)
38.21(a) |
|
34751 NM_135802.3 NP_609646.1 |
ENSEMBL Gene Tree for TARBP2 (if available)
TreeFam Gene Tree for TARBP2 (if available) |
Paralogs
for TARBP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TARBP2 gene
- STAU22 PRKRA2 STAU12
6 SIMAP similar genes for TARBP2 using alignment to 10 protein entries: TRBP2_HUMAN (see all proteins):PRKRA ADAR DGCR8 STAU2 STAU2 variant protein STAU1
TARBP2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TARBP2
PGOHUM00000249766
|
Genomic Variants
for TARBP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TARBP2 (53894705 - 53900215 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TARBP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TARBP2 |
|
Disorders
/ Diseases
for TARBP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TARBP2 for disorders About GeneDecksing
OMIM gene information: 605053
OMIM disorders: --
14  diseases for TARBP2: About MalaCardsacquired immunodeficiency syndrome pleuropulmonary blastoma immunodeficiency blastoma
renal cell carcinoma vaginitis esophageal cancer esophagitis
colon cancer colorectal cancer carcinoma pancreatic cancer
hiv type 1 pancreatitis
1 disease from the University of Copenhagen DISEASES database for TARBP2:Pleuropulmonary blastoma 2 Novoseek disease relationships for TARBP2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TARBP2 (5 documents)
Export disorders for TARBP2 gene to outside databases
|
Publications
for TARBP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TARBP2 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with TARBP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. (PubMed id 2011739)1, 2, 3, 9 Gatignol A.... Jeang K.T. (1991)
- Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. (PubMed id 11641396)1, 2, 9 Bannwarth S.... Gatignol A. (2001)
- Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. (PubMed id 11438532)1, 2, 9 Daher A....Gatignol A. (2001)
- A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. (PubMed id 19219043)1, 2, 9 Melo S.A.... Esteller M. (2009)
- TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. (PubMed id 15973356)1, 2, 9 Chendrimada T.P.... Shiekhattar R. (2005)
- Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. (PubMed id 8455607)1, 2, 9 Gatignol A.... Jeang K.T. (1993)
- The role of PACT in the RNA silencing pathway. (PubMed id 16424907)1, 2, 9 Lee Y.... Kim V.N. (2006)
- Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). (PubMed id 7774957)1, 2, 9 Kozak C.A.... McBride O.W. (1995)
- In vitro reconstitution of the human RISC-loading complex. (PubMed id 18178619)1, 2 MacRae I.J....Doudna J.A. (2008)
- Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. (PubMed id 17452327)1, 2 Kok K.H.... Jin D.-Y. (2007)
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External Searches for TARBP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TARBP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TARBP2 gene
(According to HUGE)
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Specialized Databases showing TARBP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TARBP2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for TARBP2 gene:
Search GeneIP for patents involving TARBP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TARBP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TARBP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TARBP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TARBP2 | | | OriGene Protein Over-expression Lysate for TARBP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TARBP2 | | OriGene 3'-UTR Clone for TARBP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TARBP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TARBP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARBP2 |
|  |  |  | | | | ThermoFisher Antibodies for TARBP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARBP2 |
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