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TARBP2 Gene

protein-coding   GIFtS: 59

GC12P052183
TAR (HIV-1) RNA binding protein 2
(Previous name: Tar (HIV-1) RNA binding protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for TARBP2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
LOQS 2
TRBP 2, 3
TRBP1 2
TRBP2 2
Descriptions
TAR (HIV) RNA binding protein 2 2
TAR (HIV) RNA-binding protein 2 2
TAR (HIV) RNA-binding protein TRBP1 2
TAR (HIV-1) RNA binding protein 2 1, 2
TAR RNA binding protein 2 2
TAR RNA-binding protein 2 2, 3
Trans-activation-responsive RNA-binding protein 3
trans-activation responsive RNA-binding protein 2
External Ids
HGNC: 115691
Entrez Gene: 68952
UniProtKB: Q156333
Ensembl: ENSG000001395467
Search outside databases for aliases for TARBP2 gene

Previous GC identifers: GC12P053890 GC12P054007 GC12P053611 GC12P052181 GC12P052182

Summaries
for TARBP2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for TARBP2:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome
that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1
gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located
downstream of the transcription initiation site. The protein encoded by this gene binds between
the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression
in synergy with the viral Tat protein. Alternative splicing results in multiple transcript
variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC
loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is
composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required
to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2.
EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate
from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs)
from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the
long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is
achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing
phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of
TAR-containing RNAs independently of EIF2AK2/PKR

Gene Wiki entry for TARBP2

Genomic Location
for TARBP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TARBP2 gene  

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.13   HGNC chromosome: 12

TARBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052183:     (about GC identifiers)

Start:
 52,180,972 bp from pter
End:
 52,186,482 bp from pter
Size:
 5,511 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  

Proteins
for TARBP2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633 (See protein sequence)
Recommended Name: RISC-loading complex subunit TARBP2  
Size: 366 amino acids; 39039 Da
Subunit: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading
complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric
RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase
activity. Interacts with DHX9, EIF6, MOV10 and PRKRA. Associates with the 60S ribosome
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus
PDB structures from and Proteopedia :
2CPN (3D)    
Secondary accessions: Q12878 Q8WY32 Q8WY33 Q9BRY2
Alternative promoter usage: 2 isoforms:  Q15633-1   Q15633-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_004169.3  NP_599150.1  NP_599151.2  


    ENSEMBL proteins: 
    ENSP00000266987 ENSP00000377885 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TRBP)
    Human Recombinant Proteins from Abnova (TARBP2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus TAS2011739
    About this table

    Antibodies for TARBP2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TARBP2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (TRBP), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TARBP2)
    Novus Biologicals Antibodies for TARBP2

    Assays for TARBP2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for TARBP2

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR001159 Ds-RNA_bd
     IPR014720 dsRNA-bd-like


       GeneDecks  TARBP2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15633

    ProtoNet protein and cluster: Q15633

    UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
    Similarity: Contains 3 DRBM (double-stranded RNA-binding) domains

    Gene Function
    for TARBP2

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TARBP2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TARBP2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004178

                  Applied Biosystems Silencer® siRNAs for TARBP2

                  Sigma-Aldrich siRNA for TARBP2  
                         Sigma-Aldrich shRNA for TARBP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TARBP2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004178
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004178
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_004178 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_134323

    UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
    Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC
    loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is
    composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required
    to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2.
    EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate
    from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs)
    from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the
    long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is
    achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing
    phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of
    TAR-containing RNAs independently of EIF2AK2/PKR

    Genatlas biochemistry entry for TARBP2:
    TAR region of HIV-1,RNA binding protein 2,homolog of mouse protamine RNA binding protein

    3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tarbp2):

    growth/sizelethality-postnatalreproductive system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725 double-stranded RNA binding IEA--
    GO:0005515 protein binding IPI16142218
    About this table

    Pathways & Interactions
    for TARBP2

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  TARBP2 


    5/86 Interacting proteins for TARBP2 (Q156331, 2 ENSP000002669873) via UniProtKB, MINT, and/or STRING (see all 86 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2C1Q9UL182, ENSP000003623003MINT-6488488 STRING (score=.941)
    DICER1Q9UPY31, 2, ENSP000003437453EBI-978581, EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 EBI-978581, EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 STRING (score=.998)
    DICER1Q9UPY31, 2, ENSP000003437453EBI-978581, EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 EBI-978581, EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 STRING (score=.998)
    EEF1A1P681042MINT-6489217 MINT-6488488
    EEF1AL7P681042MINT-6489217 MINT-6488488
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357 regulation of transcription from RNA polymerase II promoter TAS2011739
    About this table

    Drugs & Compounds
    for TARBP2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TARBP2

    Transcripts
    for TARBP2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TARBP2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TARBP2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004178

                  Sigma-Aldrich siRNA for TARBP2  
                         Sigma-Aldrich shRNA for TARBP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004178  NM_134323  NM_134324  

    REFSEQ mRNAs for TARBP2 gene (3 alternative transcripts): 

    NM_004178.4   NM_134323.1   NM_134324.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004178  NM_134323  NM_134324  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004178
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004178
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_004178 

    Additional cDNA sequence: 

    AK290737.1 AK293728.1 AK309569.1 BC002419.2 BC005860.2 BT007140.1 CR593716.1 CR597935.1 
    CR599054.1 CR602082.1 CR606145.1 CR606778.1 CR608491.1 CR608571.1 CR610050.1 CR612616.1 
    CR612865.1 CR613878.1 CR619705.1 CR626085.1 CR626705.1 M60801.1 U08998.2 

    18 DOTS entries:

    DT.214193  DT.95097655  DT.91893144  DT.121195741  DT.100822639  DT.91745147  DT.102831590  DT.75178382 
    DT.100800279  DT.100822643  DT.100822640  DT.102831589  DT.121195755  DT.121195766  DT.100662998  DT.100763316 
    DT.121195774  DT.95097640 

    24/218 AceView cDNA sequences (see all 218 ):

    CR597935 AI318049 BI771121 BC002419 NM_134323 NM_134324 BE908979 CR610050 
    BU070521 CR626085 CR602082 BF035358 BX344718 BM712822 BU182878 CR608571 
    BX458720 BQ015145 CA421368 BC005860 BF724259 BQ436002 BM562104 BQ881609 

    highest scoring ESTs for TARBP2:

    U08998 AA256046 AA436409 AA468868 AA481352 AA641626 AA651792 AA687973 AA705083 AA722865 

    Unigene Cluster for TARBP2:

    TAR (HIV-1) RNA binding protein 2
    Hs.326  [show with all ESTs]
    Unigene Representative Sequence: BC002419


    GeneLoc Exon Structure

    5/27 Alternative Splicing Database (ASD) splice patterns (SP) for TARBP2 (see all 27 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a ·
    SP1:                                                                    -     -     -     -                 -     -           -     -     -     -     -     -   
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -     -                 -     -           -     -     -     -     -     -   
    SP3:                                                                    -     -     -     -                 -     -           -     -     -     -     -     -   
    SP4:                                                                                                        -     -                 -     -     -     -     -   
    SP5:                                                                                                        -     -           -     -     -     -     -     -   

    ExUns: 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12a · 12b · 12c · 12d
    SP1:  -     -           -                                                                                                   
    SP2:  -                 -                                                                                                   
    SP3:  -                 -                                                                                                   
    SP4:  -     -           -                                                                                                   
    SP5:  -     -           -                                                                                                   

    About this scheme

    ECgene alternative splicing isoforms for TARBP2

    2 Ensembl transcripts including schematic representations:
    ENST00000266987  ENST00000394357  

    Expression
    for TARBP2

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TARBP2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TARBP2

    1 / 2 / 3

    3 probe-sets matching TARBP2 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		35657_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U08998 1.00 1.00 1.00 1

    		203677_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004178 0.60 1.00 0.82 1

    		203677_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATCTGCGCA

    SOURCE GeneReport for Unigene cluster: Hs.326

    Expression variation in blood from EXPOLDB for TARBP2

    Orthologs
    for TARBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TARBP2 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    cow
    (Bos taurus)    		 TARBP21   -- TAR (HIV-1) RNA binding protein 2 92.89(n)
    97.45(a)    		 514674  NM_001075678.1  NP_001069146.1 
    rat
    (Rattus norvegicus)    		 Tarbp21   -- TAR (HIV-1) RNA binding protein 2 89.04(n)
    93.15(a)    		 363006  NM_001034941.1  NP_001030113.1 
    mouse
    (Mus musculus)    		 Tarbp21, 5 15 (61.70 cM)5
    		 TAR (HIV) RNA binding protein 21, 5 89.41(n)1
    93.42(a)1    		 213571  NM_009319.11  NP_033345.11 
     AI4644255  AK1431885  (see all 17)
    zebrafish
    (Danio rerio)    		 wufj51e122   -- wufj51e12 76.43(n) 336141  BC055390.1 
    fruit fly
    (Drosophila melanogaster)    		 loqs1   -- loquacious 47.46(n)
    38.21(a)    		 34751  NM_135802.2  NP_609646.1 
    About this table        Species with no ortholog for TARBP2

    ENSEMBL Gene Tree for TARBP2

    Paralogs
    for TARBP2

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TARBP2 gene
    STAU22  PRKRA2  STAU12  

    SNPs/Variants
    for TARBP2

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/14 NCBI SNPs in TARBP2 are shown (see all 14 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 28)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs11265001,2
    		C,H52185710(+) GGGCTC/TCCGCC 3 S/F mis14Minor allele frequency- T:0.00EU EA WA 398
    rs22804481,2
    		C,F,H52183251(-) GGCCTC/TGGGGC 3 -- int18Minor allele frequency- T:0.09EA NA EU WA 2012
    rs71382811,2
    		F,H52184341(+) GGAATC/TGGGAG 3 -- int14Minor allele frequency- T:0.02EU EA WA 418
    --
    rs716875181,2
    		--52184500(+) AGTGC-/AACCCCG 3 N/ fra10--------
    rs32035471,2
    		--52184816(+) AGCCCA/CCCGCA 3 H/P mis1 ese31Minor allele frequency- C:0.00MN 184
    rs614999631,2
    		--52185900(+) GATATC/TGGTAT 3 I/I syn10--------
    --
    rs57982671,2
    		--52181874(+) CCCCC-/CTTGCT 3 -- int1 trp30--------
    --
    rs583403601,2
    		--52185940(+) TGGGGA/GCTGGA 3 -- int10--------
    --
    rs349398811,2
    		--52181868(+) TTCTT-/CCCCCC 3 -- int10--------
    --
    rs740896031,2
    		--52185566(+) GGCCAC/TCCAGG 3 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for TARBP2 (up to first 250kb)

    Disorders & Mutations
    for TARBP2

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 605053

    UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
  • Defects in TARBP2 may be involved in endometrial, gastric, and colorectal cancer (CRC).
    Loss of TARBP2 may lead to defects in the processing of certain microRNAs (miRNAs) that have the
    capacity to suppress tumorigenesis

    • 2 Novoseek disease relationships for TARBP2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 54.16 12 8455607 (2), 17360756 (2), 7515177 (1), 9060615 (1) (see all 9)
    tumors 0.00 2 19219043 (1)
    About this table

    Human Genome Epidemiology Navigator: TARBP2 (2 documents)

    Medical News
    for TARBP2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for TARBP2

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/59 PubMed articles for TARBP2 gene (see all 59 ):

    Search for TARBP2

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TARBP2

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6895 HGNC: 11569 AceView: TARBP2 Ensembl:ENSG00000139546 euGenes: HUgn6895
    ECgene: TARBP2 H-InvDB: TARBP2

    Other Databases showing TARBP2

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing TARBP2

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for TARBP2

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for TARBP2

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TARBP2:
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TARBP2

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