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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TARBP2 Gene

protein-coding   GIFtS: 59
GCID: GC12P053890

TAR (HIV-1) RNA Binding Protein 2

(Previous name: Tar (HIV-1) RNA binding protein 2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAR (HIV-1) RNA Binding Protein 21 2     RISC-Loading Complex Subunit TARBP22
Trans-Activation-Responsive RNA-Binding Protein2 3     TAR (HIV) RNA Binding Protein 22
TRBP2 3     TAR (HIV) RNA-Binding Protein 22
TAR RNA-Binding Protein 22 3     TAR (HIV) RNA-Binding Protein TRBP12
LOQS2     TAR RNA Binding Protein 22
TRBP12     Trans-Activation Responsive RNA-Binding Protein2
TRBP22     

External Ids:    HGNC: 115691   Entrez Gene: 68952   Ensembl: ENSG000001395467   OMIM: 6050535   UniProtKB: Q156333   

Export aliases for TARBP2 gene to outside databases

Previous GC identifers: GC12P054007 GC12P053611 GC12P052181 GC12P052182 GC12P052183 GC12P050934


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TARBP2 Gene:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a
chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the
transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription
initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA
regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative
splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TARBP2 Gene: 
TARBP2 (TAR (HIV-1) RNA binding protein 2) is a protein-coding gene. Diseases associated with TARBP2 include pleuropulmonary blastoma, and acquired immunodeficiency syndrome, and among its related super-pathways are MicroRNA (miRNA) Biogenesis and Generic Transcription Pathway. GO annotations related to this gene include siRNA binding and protein homodimerization activity. An important paralog of this gene is PRKRA.

UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading
complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and
TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature
miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may
subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs
(siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long
terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at
least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of
EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR

Gene Wiki entry for TARBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TARBP2 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTARBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TARBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TARBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

TARBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARBP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053890:  view genomic region     (about GC identifiers)

Start:
53,894,705 bp from pter      End:
53,900,215 bp from pter
Size:
5,511 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633 (See protein sequence)
Recommended Name: RISC-loading complex subunit TARBP2  
Size: 366 amino acids; 39039 Da
Subunit: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex
(miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as
RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and
PRKRA. Associates with the 60S ribosome
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus
3 PDB 3D structures from and Proteopedia for TARBP2:
2CPN (3D)        3ADL (3D)        3LLH (3D)    
Secondary accessions: Q12878 Q8WY32 Q8WY33 Q9BRY2
Alternative promoter usage: 2 isoforms:  Q15633-1   Q15633-2   

Explore the universe of human proteins at neXtProt for TARBP2: NX_Q15633

Explore proteomics data for TARBP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15633

  • TARBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TARBP2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004169.3  NP_599150.1  NP_599151.2  

    ENSEMBL proteins: 
     ENSP00000450320   ENSP00000266987   ENSP00000416077   ENSP00000449537   ENSP00000447993  
     ENSP00000448199   ENSP00000447262   ENSP00000458011   ENSP00000448948   ENSP00000448943  
     ENSP00000377885   ENSP00000447767  
    Reactome Protein details: Q15633
    Human Recombinant Protein Products for TARBP2: 
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    Novus Biologicals TARBP2 Proteins
    Novus Biologicals TARBP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TARBP2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA17452327
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IDA15973356
    GO:0048471perinuclear region of cytoplasm IEA--

    TARBP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001159 Ds-RNA-bd
     IPR014720 dsRNA-bd-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15633

    ProtoNet protein and cluster: Q15633

    UniProtKB/Swiss-Prot: TRBP2_HUMAN, Q15633
    Similarity: Belongs to the TARBP2 family
    Similarity: Contains 3 DRBM (double-stranded RNA-binding) domains


    TARBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRBP2_HUMAN, Q15633
    Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading
    complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and
    TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature
    miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may
    subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs
    (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long
    terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at
    least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of
    EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR

         Genatlas biochemistry entry for TARBP2:
    TAR region of HIV-1,RNA binding protein 2,homolog of mouse protamine RNA binding protein

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding ----
    GO:0005515protein binding IPI15973356
    GO:0035197siRNA binding IDA15973356
    GO:0042803protein homodimerization activity IPI17452327
         
    TARBP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TARBP2:
     Decreased cell number 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tarbp2):
     growth/size  mortality/aging  reproductive system 

    TARBP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tarbp2tm1Reb for TARBP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TARBP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TARBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TARBP2 
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    hsa-miR-34b* hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTARBP2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TARBP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulatory RNA pathways
    MicroRNA (miRNA) Biogenesis0.88
    Regulatory RNA pathways0.88
    2Generic Transcription Pathway
    Gene Expression0.47
    3Post-transcriptional Silencing By Small RNAs
    Small Interfering RNA (siRNA) Biogenesis0.40
    4RNAi Pathway
    RNAi Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TARBP2
        RNAi Pathway

    4        Reactome Pathways for TARBP2
        MicroRNA (miRNA) Biogenesis
    Regulatory RNA pathways
    Gene Expression
    Small Interfering RNA (siRNA) Biogenesis



    TARBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TARBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/85 Interacting proteins for TARBP2 (Q156331, 2, 3 ENSP000002669874) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKRAO755692, 3, ENSP000003181764MINT-1958051 MINT-8267435 I2D: score=3 STRING: ENSP00000318176
    DICER1Q9UPY31, 2, 3, ENSP000003437454EBI-978581,EBI-395506 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 I2D: score=7 STRING: ENSP00000343745
    AGO2Q9UKV82, 3, ENSP000002205924MINT-6489217 MINT-1957947 I2D: score=2 STRING: ENSP00000220592
    TGIF2Q9GZN23, ENSP000003629794I2D: score=1 STRING: ENSP00000362979
    EIF2AK2P195251, 3, ENSP000002330574EBI-978581,EBI-640775 I2D: score=3 STRING: ENSP00000233057
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS8723388
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS2011739
    GO:0006417regulation of translation IEA--
    GO:0006469negative regulation of protein kinase activity TAS11641396
    GO:0010467gene expression TAS--

    TARBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TARBP2 (TRBP2)

    Search CenterWatch for drugs/clinical trials and news about TARBP2 / TRBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TARBP2 gene (3 alternative transcripts): 
    NM_004178.4  NM_134323.1  NM_134324.2  

    Unigene Cluster for TARBP2:

    TAR (HIV-1) RNA binding protein 2
    Hs.326  [show with all ESTs]
    Unigene Representative Sequence: BC002419
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000550147(uc001sdr.3) ENST00000266987(uc001sdp.3 uc001sdo.3)
    ENST00000456234 ENST00000552857 ENST00000549610(uc009znb.3) ENST00000546889
    ENST00000548971 ENST00000547388 ENST00000552650 ENST00000547064 ENST00000551741
    ENST00000552817 ENST00000549028 ENST00000549572(uc001sdt.3) ENST00000549679
    ENST00000394357 ENST00000550407 ENST00000551157
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB593181.1 AK290737.1 AK293728.1 AK309569.1 BC002419.2 BC005860.2 BT007140.1 M60801.1 
    U08998.2 

    18 DOTS entries:

    DT.214193  DT.95097655  DT.91893144  DT.121195741  DT.91745147  DT.100822639  DT.75178382  DT.100800279 
    DT.102831590  DT.102831589  DT.121195766  DT.100822643  DT.100662998  DT.100763316  DT.121195774  DT.95097640 
    DT.100822640  DT.121195755 

    24/218 AceView cDNA sequences (see all 218):

    NM_004178 BE908979 BX417745 CR608491 BU956616 CD672162 BX344718 AW593196 
    BU182878 CR593716 BQ212917 CD672161 CR612865 BQ575416 CB241941 BU738408 
    CD674625 NM_134324 BQ015145 CF530008 CR626705 AU098384 CR606778 AW087235 

    GeneLoc Exon Structure

    5/27 Alternative Splicing Database (ASD) splice patterns (SP) for TARBP2 (see all 27)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a ·
    SP1:                                                                    -     -     -     -                 -     -           -     -     -     -     -     -   
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -     -                 -     -           -     -     -     -     -     -   
    SP3:                                                                    -     -     -     -                 -     -           -     -     -     -     -     -   
    SP4:                                                                                                        -     -                 -     -     -     -     -   
    SP5:                                                                                                        -     -           -     -     -     -     -     -   

    ExUns: 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12a · 12b · 12c · 12d
    SP1:  -     -           -                                                                                                   
    SP2:  -                 -                                                                                                   
    SP3:  -                 -                                                                                                   
    SP4:  -     -           -                                                                                                   
    SP5:  -     -           -                                                                                                   


    ECgene alternative splicing isoforms for TARBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TARBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGCGCA
    TARBP2 Expression
    About this image


    See TARBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TARBP2

    SOURCE GeneReport for Unigene cluster: Hs.326
        SABiosciences Custom PCR Arrays for TARBP2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TARBP2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tarbp21 , 5 TAR (HIV) RNA binding protein 21, 5 90.14(n)1
    94.79(a)1
      15 (57.65 cM)5
    213571  NM_009319.31  NP_033345.21 
     1025181925 
    lizard
    (Anolis carolinensis)
    Reptilia TARBP26
    TAR (HIV-1) RNA binding protein 2
    75(a)
    1 ↔ 1
    2(73133323-73151914)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37342 Xenopus laevis transcribed sequence with weak similarity more 75.53(n)    CB209671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj51e122 wufj51e12 76.43(n)   336141  BC055390.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta loqs1 loquacious 47.46(n)
    38.21(a)
      34751  NM_135802.3  NP_609646.1 


    ENSEMBL Gene Tree for TARBP2 (if available)
    TreeFam Gene Tree for TARBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TARBP2 gene
    PRKRA2  
    6 SIMAP similar genes for TARBP2 using alignment to 10 protein entries:     TRBP2_HUMAN (see all proteins):
    PRKRA    ADAR    DGCR8    STAU2    STAU2 variant protein    STAU1

    TARBP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TARBP2
    PGOHUM00000249766


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 SNPs in TARBP2 are shown (see all 103)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128158791,2
    C,H--50932296(+) GTGCTC/ATCTGA 2 -- us2k14Minor allele frequency- A:0.00NS EA 416
    rs57982671,2
    C--53895601(+) TTCTTC/-CCCCC 3 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs1862530231,2
    C--53895749(+) GCTAGA/GTGGGT 3 -- int10--------
    rs2005366801,2
    --53895787(+) TGTGCC/TCCTTC 3 -- int10--------
    rs1383142251,2
    C,F--53895829(+) CCAGGC/AAAGAC 6 /G syn12Minor allele frequency- A:0.00NA EU 5875
    rs1438140541,2
    C--53895904(+) AAAGCC/TGAGGG 6 A syn11Minor allele frequency- T:0.00NA 4550
    rs1485659921,2
    --53896044(+) TCTCTC/TTTCAC 3 -- int10--------
    rs1908185201,2
    --53896305(+) CAAATC/TCCCGT 3 -- int10--------
    rs1124755411,2
    F--53896382(+) CCGCCT/CGCCCA 3 -- int13Minor allele frequency- C:0.40CSA 5
    rs597977811,2
    C,F--53896453(+) CTAGTA/GTGTGG 3 -- int12Minor allele frequency- G:0.03WA 120

    HapMap Linkage Disequilibrium report for TARBP2 (53894705 - 53900215 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TARBP2: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605053    OMIM disorders: --

    13 diseases for TARBP2:    About MalaCards
    pleuropulmonary blastoma    acquired immunodeficiency syndrome    blastoma    hiv type 1
    esophageal cancer    skin cancer    renal cell carcinoma    esophagitis
    pancreatic cancer    colon cancer    colorectal cancer    pancreatitis
    sarcoma

    2 diseases from the University of Copenhagen DISEASES database for TARBP2:
    Shipyard eye     Pleuropulmonary blastoma

    TARBP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TARBP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 54.5 12 8455607 (2), 17360756 (2), 7515177 (1), 9060615 (1) (see all 9)
    tumors 0 3 19219043 (1), 19804757 (1)

    Genetic Association Database (GAD): TARBP2
    Human Genome Epidemiology (HuGE) Navigator: TARBP2 (5 documents)

    Export disorders for TARBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TARBP2 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with TARBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. (PubMed id 2011739)1, 2, 3, 9 Gatignol A.... Jeang K.T. (1991)
    2. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. (PubMed id 11641396)1, 2, 9 Bannwarth S.... Gatignol A. (2001)
    3. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. (PubMed id 11438532)1, 2, 9 Daher A....Gatignol A. (2001)
    4. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. (PubMed id 19219043)1, 2, 9 Melo S.A.... Esteller M. (2009)
    5. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. (PubMed id 15973356)1, 2, 9 Chendrimada T.P.... Shiekhattar R. (2005)
    6. Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. (PubMed id 8455607)1, 2, 9 Gatignol A.... Jeang K.T. (1993)
    7. The role of PACT in the RNA silencing pathway. (PubMed id 16424907)1, 2, 9 Lee Y.... Kim V.N. (2006)
    8. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). (PubMed id 7774957)1, 2, 9 Kozak C.A.... McBride O.W. (1995)
    9. A human, ATP-independent, RISC assembly machine fueled by pre- miRNA. (PubMed id 16357216)1, 2, 9 Maniataki E. and Mourelatos Z. (2005)
    10. Genetic variations in microRNA-related genes are asso ciated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1, 4 Lin J....Wu X. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6895 HGNC: 11569 AceView: TARBP2 Ensembl:ENSG00000139546 euGenes: HUgn6895
    ECgene: TARBP2 H-InvDB: TARBP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TARBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TARBP2 gene:
    Search GeneIP for patents involving TARBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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