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Aliases for TARBP2 Gene

Aliases for TARBP2 Gene

  • TAR (HIV-1) RNA Binding Protein 2 2 3
  • Trans-Activation-Responsive RNA-Binding Protein 3 4
  • TAR RNA-Binding Protein 2 3 4
  • TRBP 3 4
  • Trans-Activation Responsive RNA-Binding Protein 3
  • RISC-Loading Complex Subunit TARBP2 3
  • TAR (HIV) RNA-Binding Protein TRBP1 3
  • TAR (HIV) RNA Binding Protein 2 3
  • TAR (HIV) RNA-Binding Protein 2 3
  • TAR RNA Binding Protein 2 3
  • TRBP1 3
  • TRBP2 3
  • LOQS 3

External Ids for TARBP2 Gene

Summaries for TARBP2 Gene

Entrez Gene Summary for TARBP2 Gene

  • HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TARBP2 Gene

TARBP2 (TAR (HIV-1) RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with TARBP2 include hiv-1 and acquired immunodeficiency syndrome. Among its related pathways are Gene Expression and Regulatory RNA pathways. GO annotations related to this gene include protein homodimerization activity and siRNA binding. An important paralog of this gene is PRKRA.

UniProtKB/Swiss-Prot for TARBP2 Gene

  • Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Gene Wiki entry for TARBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARBP2 Gene

Genomics for TARBP2 Gene

Genomic Location for TARBP2 Gene

Start:
53,499,800 bp from pter
End:
53,506,431 bp from pter
Size:
6,632 bases
Orientation:
Plus strand

Genomic View for TARBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TARBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARBP2 Gene

Regulatory Elements for TARBP2 Gene

Transcription factor binding sites by QIAGEN in the TARBP2 gene promoter:

Proteins for TARBP2 Gene

  • Protein details for TARBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15633-TRBP2_HUMAN
    Recommended name:
    RISC-loading complex subunit TARBP2
    Protein Accession:
    Q15633
    Secondary Accessions:
    • Q12878
    • Q8WY32
    • Q8WY33
    • Q9BRY2

    Protein attributes for TARBP2 Gene

    Size:
    366 amino acids
    Molecular mass:
    39039 Da
    Quaternary structure:
    • Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and PRKRA. Associates with the 60S ribosome.

    Three dimensional structures from OCA and Proteopedia for TARBP2 Gene

    Alternative splice isoforms for TARBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARBP2 Gene

Proteomics data for TARBP2 Gene at MOPED

Post-translational modifications for TARBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TARBP2 Gene

Domains for TARBP2 Gene

Protein Domains for TARBP2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TRBP2_HUMAN
Domain:
  • Contains 3 DRBM (double-stranded RNA-binding) domains.:
    • Q15633
Family:
  • Belongs to the TARBP2 family.:
    • Q15633
genes like me logo Genes that share domains with TARBP2: view

No data available for Gene Families for TARBP2 Gene

Function for TARBP2 Gene

Molecular function for TARBP2 Gene

GENATLAS Biochemistry: TAR region of HIV-1,RNA binding protein 2,homolog of mouse protamine RNA binding protein
UniProtKB/Swiss-Prot Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Gene Ontology (GO) - Molecular Function for TARBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 23661684
GO:0005515 protein binding IPI 15973356
GO:0019899 enzyme binding IPI 25557550
GO:0035197 siRNA binding IDA 15973356
GO:0035198 miRNA binding IEA --
genes like me logo Genes that share ontologies with TARBP2: view

Phenotypes for TARBP2 Gene

MGI mutant phenotypes for TARBP2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TARBP2:
genes like me logo Genes that share phenotypes with TARBP2: view

Animal Models for TARBP2 Gene

MGI Knock Outs for TARBP2:

miRNA for TARBP2 Gene

miRTarBase miRNAs that target TARBP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TARBP2 Gene

Localization for TARBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARBP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARBP2 Gene COMPARTMENTS Subcellular localization image for TARBP2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for TARBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 17452327
GO:0005829 cytosol TAS --
GO:0016442 RISC complex IDA 15973356
genes like me logo Genes that share ontologies with TARBP2: view

Pathways for TARBP2 Gene

genes like me logo Genes that share pathways with TARBP2: view

Pathways by source for TARBP2 Gene

Gene Ontology (GO) - Biological Process for TARBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006417 regulation of translation IEA --
GO:0006469 negative regulation of protein kinase activity TAS 11641396
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TARBP2: view

Transcripts for TARBP2 Gene

Unigene Clusters for TARBP2 Gene

TAR (HIV-1) RNA binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TARBP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - - - - - - - -
SP20: - - - - - -
SP21: - - - - - -
SP22: - - - - - -
SP23: - -
SP24: - -
SP25:
SP26: - - - - - - - -
SP27: - - - -

ExUns: 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12a · 12b · 12c · 12d
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - - - - -
SP9: - -
SP10: - -
SP11: - -
SP12: -
SP13: - -
SP14: - - -
SP15: - - -
SP16: -
SP17: - -
SP18: -
SP19: - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - -
SP26:
SP27:

Relevant External Links for TARBP2 Gene

GeneLoc Exon Structure for
TARBP2
ECgene alternative splicing isoforms for
TARBP2

Expression for TARBP2 Gene

mRNA expression in normal human tissues for TARBP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARBP2 Gene

SOURCE GeneReport for Unigene cluster for TARBP2 Gene Hs.326

genes like me logo Genes that share expressions with TARBP2: view

Orthologs for TARBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TARBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TARBP2 36
  • 100 (n)
  • 100 (a)
TARBP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TARBP2 36
  • 93.08 (n)
  • 97.54 (a)
TARBP2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARBP2 36
  • 91.8 (n)
  • 97.27 (a)
TARBP2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tarbp2 36
  • 89.95 (n)
  • 94.79 (a)
Tarbp2 16
Tarbp2 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tarbp2 36
  • 89.04 (n)
  • 93.15 (a)
lizard
(Anolis carolinensis)
Reptilia TARBP2 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3734 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tarbp2 36
  • 70.81 (n)
  • 73.33 (a)
zebrafish
(Danio rerio)
Actinopterygii tarbp2 36
  • 65.32 (n)
  • 69.08 (a)
tarbp2 37
  • 68 (a)
OneToOne
wufj51e12 36
fruit fly
(Drosophila melanogaster)
Insecta loqs 37
  • 26 (a)
OneToMany
Species with no ortholog for TARBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TARBP2 Gene

ENSEMBL:
Gene Tree for TARBP2 (if available)
TreeFam:
Gene Tree for TARBP2 (if available)

Paralogs for TARBP2 Gene

Paralogs for TARBP2 Gene

Pseudogenes.org Pseudogenes for TARBP2 Gene

genes like me logo Genes that share paralogs with TARBP2: view

Variants for TARBP2 Gene

Sequence variations from dbSNP and Humsavar for TARBP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1126500 - 53,505,659(+) GGGCT(C/T)CCGCC reference, missense, synonymous-codon, nc-transcript-variant
rs2280448 -- 53,503,200(-) GGCCT(C/T)GGGGC intron-variant
rs3203547 -- 53,504,765(+) AGCCC(A/C)CCGCA reference, missense, nc-transcript-variant
rs5798267 -- 53,501,817(+) TTCTT(-/C)CCCCC intron-variant
rs7138281 -- 53,504,290(+) GGAAT(C/T)GGGAG intron-variant

Relevant External Links for TARBP2 Gene

HapMap Linkage Disequilibrium report
TARBP2

No data available for Structural Variations from Database of Genomic Variants (DGV) for TARBP2 Gene

Disorders for TARBP2 Gene

(2) University of Copenhagen DISEASES for TARBP2 Gene

(2) Novoseek inferred disease relationships for TARBP2 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 54.5 11
tumors 0 2

Relevant External Links for TARBP2

Genetic Association Database (GAD)
TARBP2
Human Genome Epidemiology (HuGE) Navigator
TARBP2
genes like me logo Genes that share disorders with TARBP2: view

No data available for UniProtKB/Swiss-Prot for TARBP2 Gene

Publications for TARBP2 Gene

  1. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. (PMID: 2011739) Gatignol A. … Jeang K.T. (Science 1991) 2 3 4 23
  2. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. (PMID: 11438532) Daher A. … Gatignol A. (J. Biol. Chem. 2001) 3 4 23
  3. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. (PMID: 11641396) Bannwarth S. … Gatignol A. (J. Biol. Chem. 2001) 3 4 23
  4. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). (PMID: 7774957) Kozak C.A. … McBride O.W. (Genomics 1995) 3 4 23
  5. Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. (PMID: 8455607) Gatignol A. … Jeang K.T. (Mol. Cell. Biol. 1993) 3 4 23

Products for TARBP2 Gene

Sources for TARBP2 Gene

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