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Aliases for TARBP1 Gene

Aliases for TARBP1 Gene

  • TAR (HIV-1) RNA Binding Protein 1 2 3 5
  • TAR RNA-Binding Protein Of 185 KDa 3 4
  • TAR RNA-Binding Protein 1 3 4
  • TRP-185 3 4
  • TRP185 3 4
  • TRM3 3 4
  • TRNA Methyltransferase 3 Homolog (S. Cerevisiae) 2
  • TRNA Methyltransferase 3 Homolog 3
  • TAR (HIV) RNA Binding Protein 1 3
  • TAR (HIV) RNA-Binding Protein 1 3
  • TAR RNA Loop Binding Protein 3
  • EC 2.1.1.- 4

External Ids for TARBP1 Gene

Previous GeneCards Identifiers for TARBP1 Gene

  • GC01M232786
  • GC01M230099
  • GC01M230902
  • GC01M231611
  • GC01M230833
  • GC01M232593
  • GC01M234527
  • GC01M205020

Summaries for TARBP1 Gene

Entrez Gene Summary for TARBP1 Gene

  • HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TARBP1 Gene

TARBP1 (TAR (HIV-1) RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with TARBP1 include Hiv-1. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for TARBP1 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.

Gene Wiki entry for TARBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARBP1 Gene

Genomics for TARBP1 Gene

Regulatory Elements for TARBP1 Gene

Enhancers for TARBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TARBP1 on UCSC Golden Path with GeneCards custom track

Promoters for TARBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TARBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TARBP1 Gene

Chromosome:
1
Start:
234,391,313 bp from pter
End:
234,479,158 bp from pter
Size:
87,846 bases
Orientation:
Minus strand

Genomic View for TARBP1 Gene

Genes around TARBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARBP1 Gene

Proteins for TARBP1 Gene

  • Protein details for TARBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13395-TARB1_HUMAN
    Recommended name:
    Probable methyltransferase TARBP1
    Protein Accession:
    Q13395
    Secondary Accessions:
    • Q9H581

    Protein attributes for TARBP1 Gene

    Size:
    1621 amino acids
    Molecular mass:
    181675 Da
    Quaternary structure:
    • Monomer and homodimer.

    Three dimensional structures from OCA and Proteopedia for TARBP1 Gene

neXtProt entry for TARBP1 Gene

Proteomics data for TARBP1 Gene at MOPED

Post-translational modifications for TARBP1 Gene

  • Ubiquitination at Lys 239 and Lys 449
  • Modification sites at PhosphoSitePlus

Other Protein References for TARBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TARBP1 Gene

Domains & Families for TARBP1 Gene

Suggested Antigen Peptide Sequences for TARBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13395

UniProtKB/Swiss-Prot:

TARB1_HUMAN :
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
genes like me logo Genes that share domains with TARBP1: view

No data available for Gene Families for TARBP1 Gene

Function for TARBP1 Gene

Molecular function for TARBP1 Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.

Enzyme Numbers (IUBMB) for TARBP1 Gene

Gene Ontology (GO) - Molecular Function for TARBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008173 RNA methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TARBP1: view
genes like me logo Genes that share phenotypes with TARBP1: view

Animal Model Products

CRISPR Products

miRNA for TARBP1 Gene

miRTarBase miRNAs that target TARBP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TARBP1 Gene

Localization for TARBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARBP1 Gene COMPARTMENTS Subcellular localization image for TARBP1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TARBP1 Gene

Pathways & Interactions for TARBP1 Gene

SuperPathways for TARBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TARBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with TARBP1: view

No data available for Pathways by source and SIGNOR curated interactions for TARBP1 Gene

Drugs & Compounds for TARBP1 Gene

(2) Drugs for TARBP1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Maraviroc Approved, Investigational Pharma Antagonist Selective CCR5 antagonist,antiretroviral agent 136
S-Adenosylmethionine Approved Nutra 0

(1) ApexBio Compounds for TARBP1 Gene

Compound Action Cas Number
Maraviroc Selective CCR5 antagonist,antiretroviral agent 376348-65-1
genes like me logo Genes that share compounds with TARBP1: view

Transcripts for TARBP1 Gene

Unigene Clusters for TARBP1 Gene

TAR (HIV-1) RNA binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TARBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c · 33d
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for TARBP1 Gene

GeneLoc Exon Structure for
TARBP1
ECgene alternative splicing isoforms for
TARBP1

Expression for TARBP1 Gene

mRNA expression in normal human tissues for TARBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TARBP1 Gene

This gene is overexpressed in Plasma (13.4), Heart (12.6), and Lung (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARBP1 Gene



SOURCE GeneReport for Unigene cluster for TARBP1 Gene Hs.498115

genes like me logo Genes that share expression patterns with TARBP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TARBP1 Gene

Orthologs for TARBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TARBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TARBP1 35
  • 87.23 (n)
  • 86.76 (a)
TARBP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARBP1 35
  • 87.54 (n)
  • 86.77 (a)
TARBP1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17296 35
  • 76.63 (n)
  • 74.82 (a)
Gm17296 16
Gm17296 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TARBP1 35
  • 99.14 (n)
  • 98.89 (a)
TARBP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679346 35
  • 73.73 (n)
  • 71.85 (a)
oppossum
(Monodelphis domestica)
Mammalia TARBP1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TARBP1 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TARBP1 35
  • 71.23 (n)
  • 68.71 (a)
TARBP1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TARBP1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tarbp1 35
  • 59.88 (n)
  • 55.52 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-85a20.4 35
  • 54.57 (n)
  • 49.21 (a)
TARBP1 (1 of 2) 36
  • 42 (a)
OneToMany
TARBP1 (2 of 2) 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18596 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T14B4.1 37
  • 47 (a)
T14B4.1 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM3 36
  • 17 (a)
OneToOne
TRM3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8089 36
  • 36 (a)
OneToOne
Species with no ortholog for TARBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TARBP1 Gene

ENSEMBL:
Gene Tree for TARBP1 (if available)
TreeFam:
Gene Tree for TARBP1 (if available)

Paralogs for TARBP1 Gene

No data available for Paralogs for TARBP1 Gene

Variants for TARBP1 Gene

Sequence variations from dbSNP and Humsavar for TARBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12082990 - 234,478,442(+) ACCCC(A/G)GGGAC nc-transcript-variant, reference, missense
rs10910439 - 234,465,684(+) AAGCG(C/T)ATCCA nc-transcript-variant, reference, missense
rs4920246 - 234,446,905(+) GGTAC(C/T)AAACT nc-transcript-variant, reference, missense
rs2273872 - 234,437,279(+) CACTA(C/T)TTAGC nc-transcript-variant, reference, missense
rs4272658 - 234,430,105(+) AGGGG(G/T)GAGCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TARBP1 Gene

Variant ID Type Subtype PubMed ID
esv269165 CNV Insertion 20981092
esv2665005 CNV Deletion 23128226
nsv4910 CNV Loss 18451855
esv4245 CNV Deletion 18987735
esv1010367 CNV Deletion 20482838
esv2725207 CNV Deletion 23290073
esv1731674 CNV Deletion 17803354
dgv29n21 CNV Loss 19592680
esv21821 CNV Loss 19812545

Variation tolerance for TARBP1 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.82; 91.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TARBP1 Gene

Human Gene Mutation Database (HGMD)
TARBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARBP1 Gene

Disorders for TARBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TARBP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TARBP1

Genetic Association Database (GAD)
TARBP1
Human Genome Epidemiology (HuGE) Navigator
TARBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TARBP1
genes like me logo Genes that share disorders with TARBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TARBP1 Gene

Publications for TARBP1 Gene

  1. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PMID: 8626763) Wu-Baer F. … Gaynor R.B. (J. Biol. Chem. 1996) 3 4 23 67
  2. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. (PMID: 17360756) Christensen H.S. … Gatignol A. (J. Virol. 2007) 3 23
  3. tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. (PMID: 1936997) Wu F. … Gaynor R. (Genes Dev. 1991) 2 3
  4. Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. (PMID: 1752441) Sheline C.T. … Jones K.A. (Genes Dev. 1991) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TARBP1 Gene

Sources for TARBP1 Gene

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