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TARBP1 Gene

protein-coding   GIFtS: 58
GCID: GC01M234527

TAR (HIV-1) RNA Binding Protein 1

(Previous name: Tar (HIV-1) RNA binding protein 1)
  See TARBP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAR (HIV-1) RNA Binding Protein 11 2     Probable Methyltransferase TARBP12
TRP1852 3 5     TAR (HIV) RNA Binding Protein 12
TRM32 3     TAR (HIV) RNA-Binding Protein 12
TRP-1852 3     TAR RNA Loop Binding Protein2
TAR RNA-Binding Protein 12 3     TRNA Methyltransferase 3 Homolog2
TAR RNA-Binding Protein Of 185 KDa2 3     EC 2.1.1.-3
TRNA Methyltransferase 3 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 115681   Entrez Gene: 68942   Ensembl: ENSG000000595887   OMIM: 6050525   UniProtKB: Q133953   

Export aliases for TARBP1 gene to outside databases

Previous GC identifers: GC01M232786 GC01M230099 GC01M230902 GC01M231611 GC01M230833 GC01M232593 GC01M205020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TARBP1 Gene:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a
chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the
transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription
initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded
by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during
transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length
natures have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TARBP1 Gene:
TARBP1 (TAR (HIV-1) RNA binding protein 1) is a protein-coding gene. Diseases associated with TARBP1 include acquired immunodeficiency syndrome, and hiv-1. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot: TARB1_HUMAN, Q13395
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as
tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA
polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that
TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May
act by methylating HIV-1 TAR RNA

Gene Wiki entry for TARBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_167186.2  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TARBP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTARBP1 promoter sequence
   Search Chromatin IP Primers for TARBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TARBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.3   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

TARBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TARBP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M234527:  view genomic region     (about GC identifiers)

Start:
234,527,059 bp from pter      End:
234,614,849 bp from pter
Size:
87,791 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TARB1_HUMAN, Q13395 (See protein sequence)
Recommended Name: Probable methyltransferase TARBP1  
Size: 1621 amino acids; 181675 Da
Subunit: Monomer and homodimer
1 PDB 3D structure from and Proteopedia for TARBP1:
2HA8 (3D)    
Secondary accessions: Q9H581

Explore the universe of human proteins at neXtProt for TARBP1: NX_Q13395

Explore proteomics data for TARBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys239, Lys449
  • Modification sites at PhosphoSitePlus

  • See TARBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005637.3  
    ENSEMBL proteins: 
     ENSP00000040877  

    TARBP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR025806 Prob_MeTrfase_TARBP1
     IPR001537 SpoU_MeTrfase
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q13395

    ProtoNet protein and cluster: Q13395

    1 Blocks protein domain: IPB001537 tRNA/rRNA methyltransferase (SpoU)

    UniProtKB/Swiss-Prot: TARB1_HUMAN, Q13395
    Similarity: Belongs to the RNA methyltransferase TrmH family


    Find genes that share domains with TARBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TARB1_HUMAN, Q13395
    Function: Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as
    tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA
    polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that
    TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May
    act by methylating HIV-1 TAR RNA

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005488binding ----
    GO:0008173RNA methyltransferase activity IEA--
         
    Find genes that share ontologies with TARBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TARBP1:
     Increased cell number in G1, a 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target TARBP1:
    hsa-mir-124-3p (MIRT002569)

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    4 qRT-PCR Assays for microRNAs that regulate TARBP1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTARBP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TARBP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8846792

    Find genes that share ontologies with TARBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TARBP1
    Interactions:

        Search GeneGlobe Interaction Network for TARBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TARBP1 (Q133953 ENSP000000408774) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    RNF14ENSP000003249564STRING: ENSP00000324956
    SREK1ENSP000003345384STRING: ENSP00000334538
    UBCENSP000003448184STRING: ENSP00000344818
    AGBL3ENSP000003882754STRING: ENSP00000388275
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8846792
    GO:0006396RNA processing IEA--

    Find genes that share ontologies with TARBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TARBP1 (TARB1)

    1 HMDB Compound for TARBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TARBP1 gene: 
    NM_005646.3  

    Unigene Cluster for TARBP1:

    TAR (HIV-1) RNA binding protein 1
    Hs.498115  [show with all ESTs]
    Unigene Representative Sequence: U38847
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000040877(uc001hwd.3) ENST00000483404 ENST00000462259 ENST00000496673
    ENST00000471918 ENST00000484454 ENST00000468077 ENST00000481183 ENST00000463793

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TARBP1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTARBP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TARBP1
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    GenScript: all cDNA clones in your preferred vector: TARBP1 (NM_005646)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TARBP1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TARBP1
      QuantiTect SYBR Green Assays in human, mouse, rat TARBP1
      QuantiFast Probe-based Assays in human, mouse, rat TARBP1

    Additional mRNA sequence: 

    AK055044.1 BC016023.1 U38847.1 

    11 DOTS entries:

    DT.455861  DT.92427259  DT.100785828  DT.102822591  DT.121402880  DT.92427256  DT.95082796  DT.101962808 
    DT.417658  DT.99998840  DT.92030521 

    Selected AceView cDNA sequences (see all 191):

    BX110268 BM475098 W05319 CB133843 AA367148 AI354872 BM970587 BM989347 
    AA128016 BX641192 AI538735 BM855317 AI312769 BQ434181 AI538671 AA319787 
    CD656493 AU125388 N75005 F11887 AL699826 CD557271 AW151935 CB104924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TARBP1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^
    SP1:                                                                                                                                                  -     -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c · 33d
    SP1:  -                 -     -                             -                                 
    SP2:                          -                             -                                 
    SP3:  -                                                                                       
    SP4:                    -     -     -                                                         
    SP5:                                                  -     -                                 


    ECgene alternative splicing isoforms for TARBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TARBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTTAAAC
    TARBP1 Expression
    About this image

    TARBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TARBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498115
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TARBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TARBP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm172961 , 5 predicted gene, 172961, 5 76.63(n)1
    74.82(a)1
      8 (74.10 cM)5
    2127281  NM_001159907.11  NP_001153379.11 
     1264266525 
    chicken
    (Gallus gallus)
    Aves TARBP11 Tar (HIV-1) RNA binding protein 1 71.23(n)
    68.71(a)
      421517  XM_419559.4  XP_419559.4 
    lizard
    (Anolis carolinensis)
    Reptilia TARBP16
    TAR (HIV-1) RNA binding protein 1
    60(a)
    1 ↔ 1
    1(220109561-220138200)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA793666.12   -- 74.63(n)    CA793666.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-85a20.41 si:dkey-85a20.4 54.57(n)
    49.21(a)
      566303  XM_001921839.4  XP_001921874.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG185966
    --
    23(a)
    1 ↔ 1
    3R(18201667-18205681)
    worm
    (Caenorhabditis elegans)
    Secernentea T14B4.13 rRNA methylase 47(a)   II(6736844-6741332)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM3(YDL112W)4 2'-O-ribose methyltransferase, catalyzes the ribose more   --   4(258915-263225) 851446  NP_010171.1 
    rice
    (Oryza sativa)
    Liliopsida AK063593.12   -- 71.61(n)    AK063593.1 


    ENSEMBL Gene Tree for TARBP1 (if available)
    TreeFam Gene Tree for TARBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TARBP1 (see all 2212)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830367591,2
    --234526611(+) TGCATA/GTCACC 1 -- ds50010--------
    rs118001611,2
    H--234526699(+) tcaggG/Tgatcc 1 -- ds50010--------
    rs1858575831,2
    --234526709(+) CACCCA/GCCTTG 1 -- ds50010--------
    rs124028351,2
    C,A,H--234526732(+) GTGGGG/CGGCGT 1 -- ds50015Minor allele frequency- C:0.28NA WA EA 362
    rs75248221,2
    C,F,A,H--234526868(+) CCAAAC/TGTGTT 1 -- ds500123Minor allele frequency- T:0.39NS EA WA NA CSA 2324
    rs772541041,2
    --234526877(+) TTCCCA/GAGGGG 1 -- ds50010--------
    rs1909998571,2
    --234526901(+) AAAGCA/GGCACA 1 -- ds50010--------
    rs794805221,2
    F--234527028(+) CCACAC/ATTCTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs68701,2
    C,F--234527280(-) TTTTTT/AAAAAA 1 -- ut312Minor allele frequency- A:0.11WA 120
    rs1405927951,2
    F--234527341(+) TCTCCG/ATGCGA 2 /H syn11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for TARBP1 (234527059 - 234614849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TARBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665005CNV Deletion23128226
    esv4245CNV Deletion18987735
    esv1731674CNV Deletion17803354
    esv1010367CNV Deletion20482838
    esv2725207CNV Deletion23290073
    esv269165CNV Insertion20981092
    esv21821CNV Loss19812545
    dgv29n21CNV Loss19592680
    nsv4910CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605052    OMIM disorders: --

    2 diseases for TARBP1:    
    About MalaCards
    acquired immunodeficiency syndrome    hiv-1


    Find genes that share disorders with TARBP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for TARBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 56.9 4 17360756 (2), 8626763 (1), 9230068 (1)

    Genetic Association Database (GAD): TARBP1
    Human Genome Epidemiology (HuGE) Navigator: TARBP1 (1 document)

    Export disorders for TARBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TARBP1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with TARBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PubMed id 8626763)1, 2, 9 Wu-Baer F.... Gaynor R.B. (J. Biol. Chem. 1996)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Crystal structure of the methyltransferase domain of human TARBP1. (PubMed id 18412263)1, 2 Wu H....Plotnikov A.N. (Proteins 2008)
    4. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)1, 4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. (PubMed id 7638159)1, 2 Wu-Baer F.... Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    7. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. (PubMed id 8846792)1, 2 Wu-Baer F.... Gaynor R.B. (EMBO J. 1995)
    8. tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. (PubMed id 1936997)1, 3 Wu F....Gaynor R. (amp 1991)
    9. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. (PubMed id 17360756)1, 9 Christensen H.S....Gatignol A. (J. Virol. 2007)
    10. Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. (PubMed id 1752441)1, 9 Sheline C.T....Jones K.A. (amp 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6894 HGNC: 11568 AceView: TARBP1 Ensembl:ENSG00000059588 euGenes: HUgn6894
    ECgene: TARBP1 H-InvDB: TARBP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TARBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TARBP1 gene:
    Search GeneIP for patents involving TARBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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