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Aliases for TARBP1 Gene

Aliases for TARBP1 Gene

  • TAR (HIV-1) RNA Binding Protein 1 2 3
  • TRP185 3 4 6
  • TAR RNA-Binding Protein Of 185 KDa 3 4
  • TAR RNA-Binding Protein 1 3 4
  • TRP-185 3 4
  • TRM3 3 4
  • TRNA Methyltransferase 3 Homolog (S. Cerevisiae) 2
  • Probable Methyltransferase TARBP1 3
  • TRNA Methyltransferase 3 Homolog 3
  • TAR (HIV) RNA Binding Protein 1 3
  • TAR (HIV) RNA-Binding Protein 1 3
  • TAR RNA Loop Binding Protein 3
  • EC 2.1.1.- 4

External Ids for TARBP1 Gene

Previous GeneCards Identifiers for TARBP1 Gene

  • GC01M232786
  • GC01M230099
  • GC01M230902
  • GC01M231611
  • GC01M230833
  • GC01M232593
  • GC01M234527
  • GC01M205020

Summaries for TARBP1 Gene

Entrez Gene Summary for TARBP1 Gene

  • HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TARBP1 Gene

TARBP1 (TAR (HIV-1) RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with TARBP1 include acquired immunodeficiency syndrome and hiv-1. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for TARBP1 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.

Gene Wiki entry for TARBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARBP1 Gene

Genomics for TARBP1 Gene

Genomic Location for TARBP1 Gene

Start:
234,391,313 bp from pter
End:
234,479,117 bp from pter
Size:
87,805 bases
Orientation:
Minus strand

Genomic View for TARBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TARBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARBP1 Gene

No data available for Regulatory Elements for TARBP1 Gene

Proteins for TARBP1 Gene

  • Protein details for TARBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13395-TARB1_HUMAN
    Recommended name:
    Probable methyltransferase TARBP1
    Protein Accession:
    Q13395
    Secondary Accessions:
    • Q9H581

    Protein attributes for TARBP1 Gene

    Size:
    1621 amino acids
    Molecular mass:
    181675 Da
    Quaternary structure:
    • Monomer and homodimer.

    Three dimensional structures from OCA and Proteopedia for TARBP1 Gene

neXtProt entry for TARBP1 Gene

Proteomics data for TARBP1 Gene at MOPED

Post-translational modifications for TARBP1 Gene

  • Ubiquitination at Lys239 and Lys449
  • Modification sites at PhosphoSitePlus

Other Protein References for TARBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TARBP1 Gene

Domains for TARBP1 Gene

Suggested Antigen Peptide Sequences for TARBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13395

UniProtKB/Swiss-Prot:

TARB1_HUMAN :
  • Q13395
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
genes like me logo Genes that share domains with TARBP1: view

No data available for Gene Families for TARBP1 Gene

Function for TARBP1 Gene

Molecular function for TARBP1 Gene

UniProtKB/Swiss-Prot Function: Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.

Enzyme Numbers (IUBMB) for TARBP1 Gene

Gene Ontology (GO) - Molecular Function for TARBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005488 binding --
GO:0008173 RNA methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TARBP1: view

Phenotypes for TARBP1 Gene

GenomeRNAi human phenotypes for TARBP1:
genes like me logo Genes that share phenotypes with TARBP1: view

Animal Model Products

CRISPR Products

miRNA for TARBP1 Gene

miRTarBase miRNAs that target TARBP1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TARBP1 Gene

Localization for TARBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TARBP1 Gene COMPARTMENTS Subcellular localization image for TARBP1 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TARBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8846792
genes like me logo Genes that share ontologies with TARBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TARBP1 Gene

Pathways for TARBP1 Gene

SuperPathways for TARBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TARBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8846792
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with TARBP1: view

No data available for Pathways by source for TARBP1 Gene

Compounds for TARBP1 Gene

(1) HMDB Compounds for TARBP1 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TARBP1: view

Transcripts for TARBP1 Gene

Unigene Clusters for TARBP1 Gene

TAR (HIV-1) RNA binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TARBP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TARBP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TARBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c · 33d
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for TARBP1 Gene

GeneLoc Exon Structure for
TARBP1
ECgene alternative splicing isoforms for
TARBP1

Expression for TARBP1 Gene

mRNA expression in normal human tissues for TARBP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TARBP1 Gene

SOURCE GeneReport for Unigene cluster for TARBP1 Gene Hs.498115

genes like me logo Genes that share expressions with TARBP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TARBP1 Gene

Orthologs for TARBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TARBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TARBP1 35
  • 99.14 (n)
  • 98.89 (a)
TARBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TARBP1 35
  • 87.23 (n)
  • 86.76 (a)
TARBP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TARBP1 35
  • 87.54 (n)
  • 86.77 (a)
TARBP1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17296 35
  • 76.63 (n)
  • 74.82 (a)
Gm17296 16
Gm17296 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TARBP1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TARBP1 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679346 35
  • 73.73 (n)
  • 71.85 (a)
chicken
(Gallus gallus)
Aves TARBP1 35
  • 71.23 (n)
  • 68.71 (a)
TARBP1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TARBP1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tarbp1 35
  • 59.88 (n)
  • 55.52 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-85a20.4 35
  • 54.57 (n)
  • 49.21 (a)
TARBP1 (1 of 2) 36
  • 42 (a)
OneToMany
TARBP1 (2 of 2) 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18596 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T14B4.1 36
  • 19 (a)
OneToOne
T14B4.1 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM3 36
  • 17 (a)
OneToOne
TRM3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8089 36
  • 36 (a)
OneToOne
Species with no ortholog for TARBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TARBP1 Gene

ENSEMBL:
Gene Tree for TARBP1 (if available)
TreeFam:
Gene Tree for TARBP1 (if available)

Paralogs for TARBP1 Gene

No data available for Paralogs for TARBP1 Gene

Variants for TARBP1 Gene

Sequence variations from dbSNP and Humsavar for TARBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1077 -- 234,399,095(-) TAATA(C/T)GTTGT intron-variant
rs6870 -- 234,391,534(-) TTTTT(A/T)AAAAA utr-variant-3-prime
rs12673 -- 234,391,636(-) GAGCC(C/T)TGCTG reference, synonymous-codon
rs93532 -- 234,453,917(+) CTCCA(A/G)GACAT intron-variant
rs175322 -- 234,473,518(+) TGCTG(A/C)GACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TARBP1 Gene

Variant ID Type Subtype PubMed ID
esv269165 CNV Insertion 20981092
esv2665005 CNV Deletion 23128226
nsv4910 CNV Loss 18451855
esv4245 CNV Deletion 18987735
esv1010367 CNV Deletion 20482838
esv2725207 CNV Deletion 23290073
esv1731674 CNV Deletion 17803354
dgv29n21 CNV Loss 19592680
esv21821 CNV Loss 19812545

Relevant External Links for TARBP1 Gene

HapMap Linkage Disequilibrium report
TARBP1
Human Gene Mutation Database (HGMD)
TARBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARBP1 Gene

Disorders for TARBP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TARBP1 Gene including...

Search for TARBP1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for TARBP1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 56.9 4

Relevant External Links for TARBP1

Genetic Association Database (GAD)
TARBP1
Human Genome Epidemiology (HuGE) Navigator
TARBP1
genes like me logo Genes that share disorders with TARBP1: view

No data available for UniProtKB/Swiss-Prot for TARBP1 Gene

Publications for TARBP1 Gene

  1. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PMID: 8626763) Wu-Baer F. … Gaynor R.B. (J. Biol. Chem. 1996) 3 4 23
  2. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. (PMID: 17360756) Christensen H.S. … Gatignol A. (J. Virol. 2007) 3 23
  3. Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. (PMID: 1752441) Sheline C.T. … Jones K.A. (Genes Dev. 1991) 3 23
  4. tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. (PMID: 1936997) Wu F. … Gaynor R. (Genes Dev. 1991) 2 3
  5. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. (PMID: 7638159) Wu-Baer F. … Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4

Products for TARBP1 Gene

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